FedInvent™ Patent Applications
Application Details for Thursday, July 11, 2024
This page was updated on Friday, July 19, 2024 at 04:27 PM GMT
Department of Health and Human Services (HHS)
| US 20240224960 | Pestell |
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| FUNDED BY |
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| APPLICANT(S) | Richard G. Pestell (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard G. Pestell (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-Myc, Ha-Ras, NeuT, c-Src and combinations thereof and in which said gene is expressed. Applications of the prostate cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of CCR5 and/or of at least one of its ligands. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167578 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 31/46 (20130101) A61K 31/506 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225442 | Dave et al. |
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| FUNDED BY |
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| APPLICANT(S) | PlenOptika, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shivang R. Dave (Boston, Massachusetts); Daryl Lim (Singapore, Singapore) |
| ABSTRACT | Clinical-quality eye examinations are provided at locations remote from the physician and outside of a clinical setting. A portable optical device and corresponding software are delivered to the patient's location. The portable optical device is configured for patient use in self-conducting an eye or vision exam and taking optical measurements. As a function of type of optical measurement data or health consideration of the patient, the corresponding software provides uploading and live streaming of the optical measurement data to the physician. The corresponding software is executed during the patient conducting the eye (vision) exam and enables the remotely located physician, to participate in the same via video conference. Alternatively, an artificial intelligence resource operating remotely or locally can provide physician-type guidance and eye health assessments. Alignment of device and patient eyes can be facilitated for remote exams. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559027 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0083 (20130101) A61B 3/152 (20130101) Original (OR) Class A61B 3/1015 (20130101) A61B 2560/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225475 | Hocking et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle M. Hocking (Nashville, Tennessee); Colleen M. Brophy (Nashville, Tennessee); Bret D. Alvis (Nashville, Tennessee) |
| ABSTRACT | A system includes one or more processors, a user interface, a. sensor, and a. computer readable medium storing instructions that, when executed by the one or more processors, cause the system to perform functions. The functions include generating, via the sensor, a signal representing vibrations originating from a. blood vessel of a patient and generating an intensity' spectrum of the signal that indicates intensities of the vibrations with respect to oscillation frequencies of the vibrations. The functions also include identifying a first peak of the intensity spectrum that corresponds to a respiratory' frequency of the patient and a second peak of the intensity spectrum that corresponds to a heart rate of the patient. The functions also include performing a comparison of a. first intensity of the first peak with a second intensify of the second peak and generating, via the user interface, output indicative of the comparison. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/559897 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/03 (20130101) A61B 5/0803 (20130101) A61B 5/0816 (20130101) Original (OR) Class A61B 5/02133 (20130101) A61B 5/4836 (20130101) A61B 5/6817 (20130101) A61B 5/6821 (20130101) A61B 5/6822 (20130101) A61B 5/6824 (20130101) A61B 5/6829 (20130101) A61B 5/6831 (20130101) A61B 5/7246 (20130101) A61B 5/7257 (20130101) A61B 5/7435 (20130101) A61B 2560/0462 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225536 | Viswanath et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satish E. Viswanath (Beachwood, Ohio); Florian Rieder (Shaker Heights, Ohio); Prathyush Chirra (Cleveland, Ohio); Joseph Sleiman (Pittsburgh, Pennsylvania); Namita Sharma Gandhi (Chagrin Falls, Ohio); Ilyssa Gordon (Beachwood, Ohio) |
| ABSTRACT | The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including accessing an imaging data set having one or more radiological images of a patient having Crohn's disease, the one or more radiological images including one or more intestinal strictures; identifying a plurality of determinative features from within the one or more intestinal strictures in the one or more radiological images, the plurality of determinative features being associated with one or more pathological features used to identify inflammation or fibrosis within an intestinal stricture; and applying a machine learning model to the plurality of determinative features to identify an extent of inflammation or fibrosis within the one or more intestinal strictures. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971065 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4255 (20130101) A61B 5/4842 (20130101) Original (OR) Class A61B 5/7264 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/40 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/30028 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225671 | MAXWELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam D. MAXWELL (Ann Arbor, Michigan); Zhen XU (Ann Arbor, Michigan); Hitinder S. GURM (Ann Arbor, Michigan); Charles A. CAIN (Ann Arbor, Michigan) |
| ABSTRACT | Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.” |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329459 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0536 (20130101) A61B 17/2258 (20130101) A61B 17/22004 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225764 | Behrens et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael R. Behrens (Loudon, New Hampshire); Warren RUDER (West Mifflin, Pennsylvania) |
| ABSTRACT | A system for controlling a magnetic microdevice to move within a fluidic environment, comprising an imaging device, a multi-axis electromagnet for generating a magnetic field based on sinusoidal current signals, and a controller for controlling the multi-axis electromagnet based on a machine-learning model, and wherein for training the machine-learning model, the controller is configured to receive images of the fluidic environment and the magnetic microdevice from the imaging device, determine a state comprising position information of the magnetic microdevice based on the images, calculate a measure of performance associated with a first set of sinusoidal current signals previously inputted to the multi-axis electromagnet, wherein the calculated measure of performance is used to adjust parameters of the machine-learning model, and generate based on the position information and the first set of sinusoidal current signals using the machine-learning model, a second set of sinusoidal current signals as inputs for the multi-axis electromagnet. |
| FILED | Wednesday, March 20, 2024 |
| APPL NO | 18/610786 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/72 (20160201) A61B 34/73 (20160201) Original (OR) Class A61B 2034/731 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/038 (20130101) G01R 33/385 (20130101) Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) Image Data Processing or Generation, in General G06T 7/70 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226010 | JANORKAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Mississippi Medical Center (Jackson, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amol V. JANORKAR (Madison, Mississippi); Jared S. COBB (Jackson, Mississippi); John J. CORREIA (Jackson, Mississippi); Valeria ZAI-ROSE (Flowood, Mississippi) |
| ABSTRACT | This disclosure relates to macro- and micro-sized elastin-like polymers (ELP). The addition of a polyethyleneimine (PEI) block to the terminal end of ELP allows the particle radius as well as LCST to be controlled by changing any combination of polymer concentration, ion concentration, and pH. The addition of the PEI block also provides the ability to crosslink the copolymers and achieve a stable particle radius. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373749 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 9/1658 (20130101) Original (OR) Class A61K 9/1682 (20130101) A61K 45/06 (20130101) A61K 47/6927 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226012 | Graham et al. |
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| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Barney S. Graham (Smyrna, Georgia); Masaru Kanekiyo (Chevy Chase, Maryland); Hadi M. Yassine (Boyds, Maryland) |
| ABSTRACT | Novel, nanoparticle-based vaccines are provided that elicit an immune response to a broad range of infectious agents, such as influenza viruses. The nanoparticles comprise a heterogeneous population of fusion proteins, each comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to one or more immunogenic portions of a protein from an infectious agent, such as influenza virus. The fusion proteins self-assemble to form nanoparticles that display a heterogeneous population of immunogenic portions on their surface. When administered to an individual, such nanoparticles elicit an immune response to different strains, types, subtypes and species with in the same taxonomic family. Thus, such nanoparticles can be used to vaccinate an individual against infection by different Types, subtypes and/or strains of infectious agents. Also provided are specific fusion proteins, nucleic acid molecules encoding such fusion proteins and methods of using nanoparticles of the invention to vaccinate individuals. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/167 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 2039/70 (20130101) A61K 2039/575 (20130101) A61K 2039/6031 (20130101) A61K 2039/6068 (20130101) A61K 2039/6075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101) C12N 2760/16171 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226039 | BEG et al. |
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| FUNDED BY |
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| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amer BEG (Tampa, Florida); Xiaoqing YU (Tampa, Florida) |
| ABSTRACT | Disclosed herein is a method for treating a solid tumor in a subject that involves assaying a sample from the subject for expression of two or more Histone deacetylases (HDACs); determining a response score from the expression of the two or more HDACs, wherein the response score predicts whether the subject will respond to combination immunotherapy and HDAC inhibitor therapy; and administering to the subject a therapeutically effective amount of a combination of immunotherapy and an HDAC inhibitor. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563581 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226054 | CANNON |
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| FUNDED BY |
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| APPLICANT(S) | The Regents Of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents Of the University of California (Oakland, California) |
| INVENTOR(S) | Stephen C. CANNON (Los Angeles, California) |
| ABSTRACT | Methods are described for preventing or treating skeletal diseases such as period paralysis by administering to a subject a Kv7 channel opener. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383256 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226065 | Lippman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | Marc E. Lippman (Washington, District of Columbia); Barry I. Hudson (Falls Church, Virginia); Jeanne Mandelblatt (Garrett Park, Maryland); G. William Rebeck (Washington, District of Columbia) |
| ABSTRACT | A method of treating cancer-related cognitive decline (CRCD) in a patient, in which the method comprises administering to the patient an effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE). The inhibitor of RAGE may be administered as a single dose or as multiple doses before the administration of the cancer therapy, during the administration of the cancer therapy, after the administration of the cancer therapy, or a combination thereof. Administration of the inhibitor of RAGE may improve attention, processing speed, executive functioning, learning, memory, or a combination thereof, of the patient as compared to patients who are not administered the inhibitor of RAGE. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/290252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/4164 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226067 | Selaru et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Florin M. Selaru (Baltimore, Maryland); Laura Ensign-Hodges (Baltimore, Maryland); Ling Li (Baltimore, Maryland); Min Kyung Joo (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides methods, uses, and pharmaceutical compositions comprising and azole derivative (e.g., sulconazole) in the treatment or prevention of fibrotic disease or disorder or fibrosis, including Crohn's disease. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 18/548423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4174 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226117 | HOFFMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | ReveraGen BioPharma, Inc. (Rockville, Maryland) |
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| INVENTOR(S) | Eric HOFFMAN (Rockville, Maryland); Jesse DAMSKER (Alexandria, Virginia) |
| ABSTRACT | The present disclosure provides a method of treating or reducing the symptoms of congenital adrenal hypoplasia in a human patient, comprising administering to the human patient in need thereof a therapeutically effective amount of vamorolone or a salt or polymorph thereof. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/607927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/0053 (20130101) A61K 31/573 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/26 (20130101) A61K 47/36 (20130101) A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226118 | Collins et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Betlhesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter L. Collins (Silver Spring, Maryland); Matthias Lingemann (Bethesda, Maryland); Shirin Munir (Potomac, Maryland) |
| ABSTRACT | Embodiments of a method for inhibiting viral infection in a subject are provided herein. In some embodiments, the method comprises administration of a competitive antagonist of ouabain binding to ATP1A1 to inhibit respiratory syncytial virus infection in the subject. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538065 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 31/58 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226124 | BABAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Babak BABAN (Augusta, Georgia); Jack YU (Augusta, Georgia); Krishnan M. DHANDAPANI (Augusta, Georgia) |
| ABSTRACT | A method of reducing symptoms of a neurodegenerative disease comprising administering an effective amount of cannabidiol to a subject in need thereof to improved cognitive function and ameliorated the pathophysiology of the neurodegenerative disease. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/658 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226129 | Grindrod et al. |
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| FUNDED BY |
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| APPLICANT(S) | Shuttle Pharmaceuticals, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Grindrod (Rockville, Maryland); Mira Jung (Rockville, Maryland); Olga Timofeeva (Rockville, Maryland); Milton Brown (Rockville, Maryland); Anatoly Dritschilo (Rockville, Maryland) |
| ABSTRACT | Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 2121/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240226138 — WATER-ACTIVATED MUCOADHESIVE COMPOSITIONS TO REDUCE INTESTINAL ABSORPTION OF NUTRIENTS
| US 20240226138 | Karp et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. Karp (Brookline, Massachusetts); Yuhan Lee (Cambridge, Massachusetts); Ali Tavakkoli (Boston, Massachusetts); Tarawatie E. Deelman (Boston, Massachusetts) |
| ABSTRACT | This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body. |
| FILED | Thursday, April 27, 2023 |
| APPL NO | 18/308616 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/737 (20130101) Original (OR) Class A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226152 | Saha et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishanu Saha (Madison, Wisconsin); Lauren Sarko (Middleton, Wisconsin) |
| ABSTRACT | Described herein are methods using CRISPR-Cas9 and DNA templates that can generate chimeric antigen receptors (CARs) on T cells to target the cell surface protein urokinase Plasminogen Activator Receptor (uPAR) on senescent cells. Also described are methods of preparing CAR T cells, their use to treat neurodegenerative disease, stroke, craniocerebral trauma and/or accident, or elderly individuals in need of treatment for aging. |
| FILED | Monday, April 03, 2023 |
| APPL NO | 18/295036 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464429 (20230501) A61K 2239/15 (20230501) A61K 2239/17 (20230501) A61K 2239/21 (20230501) A61K 2239/22 (20230501) Peptides C07K 14/005 (20130101) C07K 16/2896 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0056 (20130101) C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226155 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jocelyn Kim (Encino, California); Jerome A. Zack (Tarzana, California) |
| ABSTRACT | Disclosed herein are compositions, kits, combination products, and methods that comprise a latency reversing agent such as a bryostatin compound, e.g., SUW133, in combination with NK cells for reducing amounts of a human immunodeficiency virus (HIV) in subjects. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/393997 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226156 | Horton et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maureen Renee Horton (Baltimore, Maryland); Jonathan D. Powell (Baltimore, Maryland); Samuel L. Collins (Baltimore, Maryland); Yee Choi Chan Li (Baltimore, Maryland) |
| ABSTRACT | Provided herein are TRM cells, compositions thereof and methods of use thereof. The TRM cells inhibit profibrotic gene expression, suppress profibrotic inflammatory conditions, and inhibit and remediate fibrotic pathogenesis. The TRM cells can localize to specific tissues, enabling tissue and organ-targeted treatment. The methods of use include methods of treating and/or preventing fibrosis, including pulmonary fibrosis. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404727 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/464429 (20230501) A61K 2239/38 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226161 | HUSE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Sloan-Kettering Institute for Cancer Research (New York, New York); Memorial Hospital for Cancer and Allied Diseases (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Morgan HUSE (New York, New York); Minggang ZHANG (New York, New York) |
| ABSTRACT | Provided herein are compositions, kits, and methods for manufacturing cells for adoptive cell therapy comprising engineered immune cells that overexpress miR200c and/or EpCAM. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/546936 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464466 (20230501) A61K 45/06 (20130101) A61K 2239/31 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226166 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Yunmin Chang (Atlanta, Georgia); Rafi Ahmed (Atlanta, Georgia); Tahseen H. Nasti (Snellville, Georgia) |
| ABSTRACT | This disclosure relates to CD8 positive stem-like chronic memory cells for uses in managing diseases and conditions associated with T cell exhaustion and compositions related thereto. In certain embodiments. the CD8 positive cells are PD-1 positive or PD-1 negative. CD62L positive. CD127 positive, and CD44 positive. In certain embodiments. this disclosure relates to methods of treating cancer. chronic viral infections. or chronic diseases comprising administering to a patient in need thereof an effective amount of CD8 positive stem-like chronic memory cells optionally in combination with checkpoint inhibitors. In certain embodiments. the CD8 positive stem-like chronic memory cells are derived from the patient to be treated. are optionally expanded ex vivo, and optionally express a chimeric antigen receptor. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 18/577171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464411 (20230501) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/70517 (20130101) C07K 14/70564 (20130101) C07K 16/2818 (20130101) C07K 16/2827 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226179 | NAJI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Ali NAJI (North Wales, Pennsylvania); Ming YU (Wallingford, Pennsylvania) |
| ABSTRACT | This disclosure provides a culture media that facilitates survival and/or engraftment of transplanted cells. In one embodiment, this culture media comprises collagen I, albumin, L-glutamine and NaHCO3. In one embodiment, this culture media promotes enhanced survival and engraftment of β-cells of human pancreatic islets transplanted under the skin. The protective effect of this culture media is mediated, at least partly, by upregulating anti-apoptotic signaling pathways. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/801959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 33/00 (20130101) A61K 35/39 (20130101) Original (OR) Class A61K 38/38 (20130101) A61K 38/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226180 | Harrell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MAM Holdings of West Florida, L.L.C. (Palm Harbor, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl Randall Harrell (Tarpon Springs, Florida) |
| ABSTRACT | The present disclosure is directed to compositions, formulations, and methods for treating diseases of the eye and other disorders. Specifically, d-MAPPS compositions, which may include d-MAPPS solutions (e.g., in liquid form and/or administered as eye drops), can be used for topical application to the eye and treatment of, for instance, dry eye, dry eye disease, dry eye discomfort, tear hyperosmolarity, and tear hyperosmolarity-induced pathological changes in the eyes of patients. The d-MAPPS solutions can contain mesenchymal stem cells (MSC), MSC-derived exosomes (MSC-Exos), one or more MSC-sourced growth factors, and/or immunoregulatory proteins. In some embodiments, the d-MAPPS solutions can include a sterile de-cellularized human amniotic fluid (D-HAF). In embodiments, the d-MAPPS solutions are amenable to long-term storage without the loss of biological potency. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 35/50 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226193 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linden Hu (Sharon, Massachusetts); Louis Cornacchione (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions and methods for treating periodontal disease. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/744 (20130101) Original (OR) Class A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226211 | Luesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Hendrik Luesch (Gainesville, Florida); Michelle S. Bousquet (Gainesville, Florida) |
| ABSTRACT | The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494658 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/105 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 8/347 (20130101) A61K 8/498 (20130101) A61K 31/055 (20130101) A61K 31/085 (20130101) A61K 31/352 (20130101) A61K 36/05 (20130101) Original (OR) Class A61K 2236/33 (20130101) A61K 2236/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226212 | Rao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reeta Rao (Newton, Massachusetts); Eric M. Young (Worcester, Massachusetts); Lohith Kunyeit (Worcester, Massachusetts); K. A. Anu-Appaiah (Karnataka, India); Joseph H. Collins (Worcester, Massachusetts) |
| ABSTRACT | A formulated composition for treating or preventing epithelial fungal infection and correcting dysbiosis in or on a subject provides an effective dose of yeast cells containing a plurality of genes encoding functions of tolerance to a high temperature, tolerance to high and low pH, adherence to cells of the subject, and biosynthesis of amino acid alcohols. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404140 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/32 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 3/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 36/064 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226232 | NAGARAJ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado); The University of North Texas Health Science Center at Fort Worth (Forth Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ram H. NAGARAJ (Aurora, Colorado); Rooban B. NAHOMI (Aurora, Colorado); Dorota L. STANKOWSKA (Forth Worth, Texas) |
| ABSTRACT | Peptide-based therapies for a retinal disease, injury, or condition in a subject involve administering to the subject a pharmaceutical composition containing at least one peptide derived from a heat shock protein, including Hsp20 and αB-crystallin. The administered peptides may be acetylated and/or conjugated to a cell-penetrating peptide. Administration of the peptides may reduce or prevent the loss of at least one retinal cell type, including retinal ganglion cells and retinal endothelial cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The pharmaceutical compositions may be administered intravitreally using an administration device. A single injection may be therapeutically sufficient for treating various ocular conditions. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547382 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 47/64 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Peptides C07K 7/06 (20130101) C07K 14/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226247 | Nakajima et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brandeis University (Waltham, Massachusetts); The Board of Trustees of the Leland Stanford Junior University Leland Stanford Junior University JUN (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuko Nakajima (Lincoln, Massachusetts); James E. Haber (Wayland, Massachusetts); Christine Jacobs-Wagner (Emerald Hills, California); Constantin N. Takacs (Medford, Massachusetts) |
| ABSTRACT | Described herein is a method of reducing virulence of a bacterial species with a segmented genome which has infected a mammalian host or mammalian host cell, by exposing the bacterial genome to an RNA-guided nuclease and a guide RNA (gRNA), thus generating a double-stranded or single-stranded break in the bacterial genome and causing loss of the targeted genome segment. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/469664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/74 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2800/101 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226257 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Justin J. Taylor (Seattle, Washington); Denise Galloway (Seattle, Washington); Paul Nghiem (Seattle, Washington); David Koelle (Seattle, Washington); Haroldo Rodriguez (Seattle, Washington); Joseph Carter (Seattle, Washington) |
| ABSTRACT | Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses. Related diagnostics are also described |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001111 (20180801) Original (OR) Class A61K 45/06 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/57492 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226260 | Abraham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durtham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soman Abraham (Durham, North Carolina); Jianxuan Wu (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are vaccine compositions for the treatment and prevention of urinary tract infections (UT!s) and methods for delivery of the vaccine compositions. Moreover, the disclosure provides adjuvant compositions for vaccines to modulate cellular responses. such as an immune response. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/277150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/025 (20130101) A61K 39/39 (20130101) A61K 39/0258 (20130101) A61K 39/0266 (20130101) Original (OR) Class A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226266 | Balint et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etubics Corporation (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph P. Balint (Seattle, Washington); Frank R. Jones (Seattle, Washington); Richard B. Gayle, III (Seattle, Washington) |
| ABSTRACT | Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided. |
| FILED | Tuesday, March 19, 2024 |
| APPL NO | 18/609152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 38/193 (20130101) A61K 38/204 (20130101) A61K 38/208 (20130101) A61K 38/217 (20130101) A61K 38/2013 (20130101) A61K 38/2026 (20130101) A61K 38/2033 (20130101) A61K 38/2046 (20130101) A61K 38/2066 (20130101) A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 39/21 (20130101) A61K 39/235 (20130101) A61K 39/001106 (20180801) A61K 39/001182 (20180801) A61K 2039/54 (20130101) A61K 2039/57 (20130101) A61K 2039/545 (20130101) A61K 2039/575 (20130101) A61K 2039/5256 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 14/71 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10034 (20130101) C12N 2710/10321 (20130101) C12N 2710/10334 (20130101) C12N 2710/10343 (20130101) C12N 2710/10371 (20130101) C12N 2710/20034 (20130101) C12N 2740/15034 (20130101) C12N 2740/16234 (20130101) C12N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226267 | TAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ming TAN (Cincinnati, Ohio); Xi Jason JIANG (Cincinnati, Ohio) |
| ABSTRACT | The instant disclosure relates to pseudovirus nanoparticles (PVNPs) and compositions comprising PVNPs. The disclosed PVNPs may be comprised of fusion proteins that form an icosahedral structure and a nanoparticle shell. The disclosed fusion proteins may comprise a modified norovirus (NoV) S domain protein; a hemagglutinin I (HA1) antigen of the influenza hemagglutinin I (HA1) of influenza vims; and a peptide linker connecting the C-terminus of the NoV S domain to the HA1 antigen. The modified NoV S domain proteins form the interior nanoparticle shell of said PVNP composition and display the 60 HA1 antigens on the surface of the nanoparticle shell. Methods of making and using the PVNPs and compositions containing PVNPs are also disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/276905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16122 (20130101) C12N 2760/16123 (20130101) C12N 2760/16134 (20130101) C12N 2760/16222 (20130101) C12N 2760/16223 (20130101) C12N 2760/16234 (20130101) C12N 2770/16022 (20130101) C12N 2770/16023 (20130101) C12N 2770/16042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226272 | SCHIEF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. SCHIEF (La Jolla, California); Torben SCHIFFNER (La Jolla, California); Jon M. STEICHEN (La Jolla, California); Xiaozhen HU (La Jolla, California) |
| ABSTRACT | Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/257808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/88 (20130101) C12N 2740/16034 (20130101) C12N 2760/20034 (20130101) C12N 2770/20034 (20130101) Enzymes C12Y 402/0101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226273 | Jacobs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Bertram Jacobs (Tempe, Arizona); Karen Kibler (Scottsdale, Arizona) |
| ABSTRACT | Recombinant poxvirus expressing severe acute respiratory syndrome coronavirus 2 structural proteins and virus-like particles are described, along with methods of making and using the same. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 18/283042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/543 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/24143 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2840/105 (20130101) C12N 2840/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226274 | Strauch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| INVENTOR(S) | Eva-Maria Strauch (St. Louis, Missouri); Karen Juliana Gonzalez Restrepo (Athens, Georgia) |
| ABSTRACT | Recombinant viral class I fusion proteins that favor a prefusion conformational state over a postfusion conformational state, polynucleotides encoding same, vaccines comprising the proteins or polynucleotides, and methods of vaccination with the vaccines. The recombinant proteins include recombinant RSV F proteins, recombinant hMPV proteins, and recombinant SARS-COV-2 S proteins. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404463 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226276 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping ZHU (Clarksville, Maryland); Weizhong LI (College Park, Maryland); Tao WANG (Ellicott City, Maryland) |
| ABSTRACT | Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-CoV-2 or at risk of being exposed to SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. |
| FILED | Wednesday, November 22, 2023 |
| APPL NO | 18/517578 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/543 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) C12N 2770/20071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226292 | ESSER-KAHN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron ESSER-KAHN (Chicago, Illinois); Rachel STEINHARDT (Chicago, Illinois); Bradley STUDNITZER (Chicago, Illinois); Peter DEAK (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are methods and compositions related to identification, isolation, and targeting of first responder dendritic cells (FRs). Aspects of the disclosure are directed to FR-targeting agents and methods for use of such agents, including methods for directing a diagnostic, imaging, or therapeutic molecule (e.g., an antigen) to FRs. The present disclosure includes pharmaceutical compositions comprising an FR-targeting agent and an antigen or polynucleotide encoding an antigen. Also disclosed are methods for stimulating an immune response comprising targeting an antigen to FRs. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 18/558527 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4615 (20230501) Original (OR) Class A61K 39/4622 (20230501) A61K 47/6911 (20170801) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Peptides C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226304 | POROTTO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York); Erasmus University Medical Center (Rotterdam, Netherlands); INSERM (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo POROTTO (New York, New York); Anne MOSCONA (New York, New York); Rik DE SWART (Rotterdam, Netherlands); Rory DE VRIES (Rotterdam, Netherlands); Branka HORVAT (Lyon, France); Cyrille MATHIEU (Lyon, France) |
| ABSTRACT | Described herein is a composition and method of preventing COVID-19 with lipid-peptide fusion antiviral therapy. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 18/249058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 38/00 (20130101) A61K 47/543 (20170801) Original (OR) Class A61K 47/554 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226307 | Chilkoti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh Chilkoti (Durham, North Carolina); Bruce Sullenger (Durham, North Carolina); Imran Ozer (Durham, North Carolina); Angus Hucknall (Durham, North Carolina); Juliana Layzer (Durham, North Carolina); George Pitoc (Durham, North Carolina) |
| ABSTRACT | Disclosed are POEGMA-aptamer conjugates with a reduced or eliminated host-immune response. An example conjugate includes an aptamer conjugated to a POEGMA having a plurality of side chains, where each side chain includes 1 to 6 monomers of ethylene glycol repeated in tandem. Also disclosed are methods of making the conjugate and methods of using the conjugate. An example method of use includes a method of controlling coagulation in a subject. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/277915 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 47/60 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226310 | Parhiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamideh Parhiz (Gladwyne, Pennsylvania); Drew Weissman (Philadelphia, Pennsylvania); Vladimir Muzykantov (Bryn Athyn, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods for effective delivery of a therapeutic agent to a subject using a delivery vehicle comprising a domain to evade the subject's immune response. In some embodiments, the present invention relates to compositions and methods for targeted delivery of a therapeutic agent to a subject using a delivery vehicle comprising a domain to evade the subject's immune response and a domain for targeting a specific cell type. The invention also relates to methods of use of the compositions of the invention for the treatment of diseases and disorders, including the treatment of diseases and disorders in subjects having an inflammatory or autoimmune disease or disorder. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/558013 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/6425 (20170801) Original (OR) Class A61K 47/6807 (20170801) A61K 47/6925 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226334 | OLSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric N. OLSON (Dallas, Texas); Yu ZHANG (Dallas, Texas); Rhonda BASSEL-DUBY (Dallas, Texas) |
| ABSTRACT | Provided herein are gene therapy methods, vectors and constructs for the treatment of Duchenne Muscular Dystrophy in a subject. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563790 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226335 | Kariko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katalin Kariko (Rydal, Pennsylvania); Drew Weissman (Wynnewood, Pennsylvania) |
| ABSTRACT | This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/471738 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/177 (20130101) A61K 38/1816 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0041 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0075 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Peptides C07K 14/47 (20130101) C07K 14/505 (20130101) C07K 14/4712 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 5/0696 (20130101) C12N 15/67 (20130101) C12N 15/85 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/33 (20130101) C12N 2310/3341 (20130101) C12N 2501/40 (20130101) C12N 2800/95 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Enzymes C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226337 | Das et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Rhiju Das (Palo Alto, California); Hannah K. Wayment-Steele (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods to enhance RNA stability and uses thereof. Many embodiments alter the sequence of an RNA therapeutic molecule (e.g., vaccines) to encode for a variant peptide while maintaining and/or increasing stability of the RNA therapeutic. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 18/546698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226342 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vijay Sharma (St. Louis, Missouri); Lakshminarayana Satham (St. Louis, Missouri); Jothilingam Sivapackiam (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Vijay Sharma (St. Louis, Missouri); Lakshminarayana Satham (St. Louis, Missouri); Jothilingam Sivapackiam (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides compositions and methods for reactive oxygen species imaging agents. Compositions include a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b. Methods of detecting ROS in a subject include administering to the subject an effective amount of a composition comprising a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b, and exposing the subject to an imaging modality such as PET or CT. Administering the composition comprising the ROS imaging agent results in penetration of the ROS imaging agent into a membrane, oxidation of the ROS imaging 10 agent by ROS, and trapping of the ROS imaging agent in a cell membrane and intracellular compartments. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0459 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226372 | Duvall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig L. Duvall (Nashville, Tennessee); Prarthana Patil (Nashville, Tennessee); Mukesh K Gupta (Nashville, Tennessee); Joshua Tyler McCune (Nashville, Tennessee); Richard d'Arcy (Nashville, Tennessee) |
| ABSTRACT | The presently-disclosed subject matter includes hydrophilic thioketal polymers and scaffolds formed therefrom. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/288034 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 27/60 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226565 | Dayeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shadi A. Dayeh (San Diego, California); Youngbin Tchoe (San Diego, California); Andrew M. Bourhis (La Jolla, California) |
| ABSTRACT | A flexible electrode array with hundreds or thousands channels for clinical use includes an array of at least hundreds of electrodes on a flexible biocompatible polymer substrate. Perfusion through holes are provided through the substrate. Individual elongate leads connect to each of the electrodes, the elongate lead connections being supported by the flexible biocompatible polymer substrate and extending away from the array. Flexible biocompatible polymer insulates the individual elongate lead connections and supporting the array. An interposer with individual channel connections is conductively bonded to the individual elongate lead connections. Sterile bag packaging encloses a portion of the interposer, where the outer side of the package including the array and individual elongate lead is sterile while the inner side of the packaging is non-sterile. The portion interposer inside the package is configured to connect to a circuit board within the packaging. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 18/547999 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/36125 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/113 (20130101) H05K 1/181 (20130101) H05K 3/32 (20130101) H05K 2201/041 (20130101) H05K 2201/10325 (20130101) H05K 2201/10378 (20130101) H05K 2203/0384 (20130101) H05K 2203/1305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226809 | MARSH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (BLACKSBURG, Virginia) |
| ASSIGNEE(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (BLACKSBURG, Virginia) |
| INVENTOR(S) | Spencer MARSH (Roanoke, Virginia); Kevin J. PRIDHAM (Roanoke, Virginia); Linda Jane JOURDAN (Roanoke, Virginia); Robert G. GOURDIE (Roanoke, Virginia) |
| ABSTRACT | Described in certain example embodiments herein are methods of isolating exosomes from a biological fluid, such as those containing caseins. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 18/547489 |
| CURRENT CPC | Separation B01D 61/14 (20130101) Original (OR) Class B01D 2311/2676 (20130101) B01D 2315/10 (20130101) B01D 2315/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226881 | VENEZIANO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGE MASON UNIVERSITY (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi VENEZIANO (McLean, Virginia); Ramin M. HAKAMI (Bristow, Virginia); Hunter MASON (Orange, Connecticut) |
| ABSTRACT | A microfluidic intercellular communication analysis device includes a coverslip and a Polydimethylsiloxane (PDMS) layer attached to the coverslip, the PDMS layer comprising a plurality of microfluidic channels each having an inlet and an outlet, the plurality of microfluidic channels comprising a donor cell channel structured to receive a donor cell population, a recipient cell channel structured to receive at least a recipient cell population and a matrix channel comprising a diffusion barrier having pores, the donor cell channel and the recipient cell channel each comprising inlets and outlets having an arc angle ranging from 180° to 300°, the arc angle structured to prevent cell aggregation in the inlets, the outlets and/or channel surfaces thereof, wherein upon injecting the donor cell population and the recipient cell population, the target subject is imaged by an imaging device and analyzed for intercellular communication and/or functional characterizations for ensuing intercellular communication effects. |
| FILED | Friday, August 18, 2023 |
| APPL NO | 18/235564 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226887 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); Minute Molecular Diagnostics, Inc. (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin Jiwoong Kim (Evanston, Illinois); Abhishek k. Agarwal (Evanston, Illinois); Matthew Austin Butzler (Evanston, Illinois); David M. Kelso (Wilmette, Illinois); Sally M. McFall (Evanston, Illinois); Tom Westberg (Lake Forest, Illinois); Jennifer Lynn Reed (Evanston, Illinois); Kerry Berland (Evanston, Illinois) |
| ABSTRACT | Provided herein are devices (e.g., cartridges), instruments, systems, and components thereof for rapid sample processing and analyte detection (e.g., nucleic acid purification, amplification, and/or detection), and methods of use thereof. A cartridge for analyte detection may comprise: a storage section including a storage chamber; a processing section including a processing chamber; a microfluids section in fluid communication with the processing section; and a transfer capsule configured to transfer fluid between the storage chamber and the processing chamber |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/558061 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502723 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/04 (20130101) B01L 2200/16 (20130101) B01L 2200/027 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/0663 (20130101) B01L 2300/1827 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1013 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226895 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Ying Zhu (Richland, Washington); Jongmin Woo (Richland, Washington); Ljiljana Pasa-Tolic (Richland, Washington) |
| ABSTRACT | A device for biological sample preparation and analysis is disclosed. The device includes a substrate and a plurality of spaced apart arrays disposed on an upper surface of the substrate. Each array includes a plurality of reaction vessels, each reaction vessel having a hydrophilic surface. A hydrophilic ring surrounds each array. Methods of making and using the device are also disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546752 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502792 (20130101) B01L 2200/142 (20130101) B01L 2300/165 (20130101) B01L 2300/0819 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228495 | Webb et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI INTERNATIONAL (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas R. Webb (Mountain View, California); Chandraiah Lagisetti (Cupertino, California); Diane Beylkin (Thousand Oaks, California); Jaehyeon Park (Sunnyvale, California); Wei Zhou (Fremont, California); Peter Madrid (San Jose, California); Leyi Gong (San Mateo, California); Jeremiah Malerich (San Jose, California); Chat Gheong Gabriel Fung (San Francisco, California); Raymond Ng (Pleasant Hill, California); Quentin Perron (Evecquemont, France); Vinicius Barros Ribeiro da Silva (Paris, France) |
| ABSTRACT | The present disclosure is concerned with 9-hydroxy-6-(pyrrolidin-2-yl)-3, 4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione compounds for the treatment of various viral infections such as, for example, influenza virus. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/913824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228502 | LAWRENCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas LAWRENCE (Tampa, Florida); Harshani LAWRENCE (Tampa, Florida); Derek DUCKETT (Land O Lakes, Florida); Gary REUTHER (Temple Terrace, Florida) |
| ABSTRACT | This disclosure provides compounds useful for treating medical disorder, and more particularly ACK1 inhibitors useful for treating cancers. |
| FILED | Friday, April 22, 2022 |
| APPL NO | 18/556512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/541 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228527 | MICALIZIO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Glenn C. MICALIZIO (Norwich, Vermont) |
| ABSTRACT | The present disclosure relates to synthetic methods for preparing a 9-alpha-substituted or a 9-beta-substituted steroid-like compound. In particular, the disclosure relates to methods for generating a steroidal C9-C10 bond and establishing stereochemistry at C9 in such compounds. The methods provide high levels of stereoselection in the C9-C10 bond forming process. Compounds synthesized by such methods can be used as nuclear hormone receptor modulators. |
| FILED | Thursday, April 14, 2022 |
| APPL NO | 18/556033 |
| CURRENT CPC | Steroids C07J 15/005 (20130101) Original (OR) Class C07J 31/006 (20130101) C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228539 | Walensky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loren D. Walensky (Newton, Massachusetts); Gregory H. Bird (Pelham, New Hampshire); Rachel Guerra (Cambridge, Massachusetts); Edward Harvey (Weston, Massachusetts) |
| ABSTRACT | This disclosure features structurally-stabilized and/or cysteine-reactive peptide inhibitors for selective targeting of BFL-1, or dual targeting of BFL-1 and MCL-1. Also disclosed are methods of using such structurally-stabilized and cysteine-reactive peptides in the treatment of BFL-1- and/or MCL-1-expressing or -dependent cancers or diseases of cellular excess (e.g., autoimmune or inflammatory conditions). Also provided are combination therapies comprising such structurally-stabilized and/or cysteine-reactive peptides and inhibitors of the DNA damage response pathway, such as an ATM kinase inhibitor, ATR kinase inhibitor, CHK1/2 inhibitor, or PARP inhibitor; or an inhibitor of MCL-1, or a selective inhibitor of BCL-2, or an inhibitor of BCL-2/BCL-XL, for the treatment of BFL-1-expressing or -dependent cancers (e.g., AML), BFL-1 and MCL-1-expressing or -dependent cancers, or diseases of cellular excess (e.g., autoimmune or inflammatory conditions). |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228543 | Wolberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia Wolberger (Baltimore, Maryland); Michael T. Morgan (Baltimore, Maryland); Hiroaki Suga (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides peptide inhibitors of Ubiquitin-Specific Protease 22 (USP22), compositions, and methods of use thereof. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/557801 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228549 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Li Ou (Potomac, Maryland); Jason J. Gorman (Silver Spring, Maryland) |
| ABSTRACT | Immunogens comprising a recombinant Lassa virus glycoprotein complex ectodomain trimer stabilized in a prefusion closed conformation, as well as methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to Lassa virus in a subject. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/557396 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/10022 (20130101) C12N 2760/10034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228552 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min Chen (Boston, Massachusetts); Fanjun Li (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are nanopore tweezer systems that can be used to screen for allosteric inhibitors of protein kinases. In some embodiments, the protein kinase is a mutant kinase that confers resistance to chemotherapeutic drugs during cancer treatment. Therefore, the disclosed systems and methods can be used to identify drugs for treating drug resistant cancers. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482052 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/245 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228566 | SPEES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| ASSIGNEE(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| INVENTOR(S) | Jeffrey L. SPEES (Burlington, Vermont); Benjamin LIEBMAN (Burlington, Vermont) |
| ABSTRACT | The invention features methods and compositions for treating a reperfusion injury, hypofusion, ischemic injury, and/or low/no-reflow. In embodiments, the compositions contain complexes containing a basic fibroblast growth factor (FGF2) and an immunoglobulin G (IgG) polypeptide, or fragments thereof. In embodiments, the complexes further contain a hepatocyte growth factor (HGF) polypeptide, a vascular endothelial growth factor (VEGF) polypeptide, or fragments thereof. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/503 (20130101) C07K 14/4753 (20130101) Original (OR) Class C07K 16/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228593 | CASELLAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael Cristian CASELLAS (Kensington, Maryland); Jianliang XU (North Potomac, Maryland) |
| ABSTRACT | Single-domain antibodies against SARS-CoV-2 are provided. The single-domain antibodies have been shown to have neutralizing activity against SARS-CoV-2 and can be used as a diagnostic and/or therapeutic in patients with coronavirus infection, such as COVID-19; and in diseases and disorders related to, or resulting from, coronavirus infection. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/546933 |
| CURRENT CPC | Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228609 | NOELLE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randolph J. NOELLE (Plainfield, New Hampshire); Lili WANG (Norwich, Vermont) |
| ABSTRACT | The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct, Ig-superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated as PD-L3 OR VISTA or V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Expression of VISTA is primarily within the hematopoietic compartment and is highly regulated on myeloid APCs and T cells. Therapeutic intervention of the VISTA inhibitory pathway represents a novel approach to modulate T cell-mediated immunity for the treatment of a wide variety of cancers, e.g., ovarian, bladder cancer and melanomas. Also, VISTA proteins, especially multimeric VISTA proteins and antibodies may be used to suppress T cell immunity in autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis and arthritic conditions such as RA. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/476403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 14/70503 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228657 | Pastan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Ira H. Pastan (Chevy Chase, Maryland); Junxia Wei (Rockville, Maryland); Masanori Onda (Germantown, Maryland); Tapan Bera (Frederick, Maryland); Mitchell Ho (Urbana, Maryland) |
| ABSTRACT | Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/471137 |
| CURRENT CPC | Peptides C07K 14/21 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2866 (20130101) C07K 16/2878 (20130101) C07K 2317/31 (20130101) C07K 2317/73 (20130101) C07K 2317/94 (20130101) C07K 2317/569 (20130101) C07K 2317/624 (20130101) C07K 2319/33 (20130101) C07K 2319/50 (20130101) C07K 2319/55 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228668 | KOIDE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shohei KOIDE (New York, New York); Benjamin NEEL (New York, New York); Carmine FEDELE (New York, New York); Kai Wen TENG (Flushing, New York); Akiko KOIDE (New York, New York); Takamitsu HATTORI (West New York, New Jersey); Lorenzo MASO (New York, New York) |
| ABSTRACT | Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 18/547623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 16/2833 (20130101) C07K 2317/56 (20130101) C07K 2317/626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228931 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenqiang Ma (Middleton, Wisconsin); Inkyu Lee (Madison, Wisconsin); Juhwan Lee (Madison, Wisconsin); Michael Phillips (Stoughton, Wisconsin); David Gamm (Waunakee, Wisconsin); Shaoqin Gong (Middleton, Wisconsin) |
| ABSTRACT | Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/769549 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 2533/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228961 | SHERER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Nathan Mark SHERER (Madison, Wisconsin); Ryan Thomas BEHRENS (Madison, Wisconsin) |
| ABSTRACT | Genetically modified CCNT1 and XPO1 genes encoding proteins that inhibit virus infection in cells. The genetically modified CCNT1 gene encodes a protein with a C261Y substitution with respect to the human CCNT1 protein. The genetically modified XPO1 gene encodes a protein with P411T, M412V, and/or F414S substitutions with respect to the human XPO1 protein. The genetically modified CCNT1 and XPO1 genes can be introduced in cells. The cells comprising the genetically modified CCNT1 and XPO1 genes can be introduced in a subject with a virus infection to treat the infection. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/373569 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 38/16 (20130101) Peptides C07K 14/705 (20130101) C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class C12N 15/00 (20130101) C12N 15/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228965 | CALIFANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); FUNDACIÓ CENTRE DE REGULACIÓ GENÒMICA (Barcelona, Spain); INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (Barcelona, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea CALIFANO (New York, New York); Maria Pia COSMA (Barcelona, Spain); Karthik ARUMUGAM (Barcelona, Spain) |
| ABSTRACT | The method of generating multipotent stem cells is a method for producing and/or expanding multipotent stem cells by delivering at least one reprogramming protein into somatic cells. The at least one reprogramming protein includes a Master Regulator (MR) protein, which may be BAZ2B, ZBTB20, ZMAT1, CNOT8, KLF12, DMTF1, HBP1, or FLI1. The bromodomain protein BAZ2B, in particular, was identified by first generating bi-species heterokaryons by fusing Tcf7l1−/− murine embryonic stem cells (ESCs) with human B-cell lymphocytes. Reprogramming of the B-cell nuclei to a multipotent state was tracked by human mRNA transcript profiling at multiple timepoints. Interrogation of a human B-cell regulatory network with gene expression signatures collected from such reprogramming time series identified eight candidate Master Regulator proteins, which were validated in human cord blood-derived hematopoietic progenitor and lineage-committed cells. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194551 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2501/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228971 | FRENETTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. FRENETTE (New York, New York); Fumio NAKAHARA (Bronx, New York) |
| ABSTRACT | A method for revitalizing mesenchymal stem cells (MSC) maintained in culture by transducing the MSC with vectors encoding a specific gene combination, as well as methods of use of MSC so revitalized in co-culturing hematopoictic stem cells. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2506/11 (20130101) C12N 2506/30 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228978 | Mueller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State of University New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for the State of University New York (Albany, New York) |
| INVENTOR(S) | Steffen Mueller (Kings Point, New York); Eckard Wimmer (East Setauket, New York); Bruce Futcher (Setauket, New York); Steve Skiena (Setauket, New York); Chen Yang (Shanghai, China PRC) |
| ABSTRACT | This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/069734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/16034 (20130101) C12N 2760/16061 (20130101) C12N 2760/16134 (20130101) C12N 2760/16162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228980 | Mehle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Mehle (Madison, Wisconsin); Jordan Ranum (Waunakee, Wisconsin); Mitchell Ledwith (San Diego, California) |
| ABSTRACT | The disclosure provides for methods for making and using modified influenza gene products, alone or in combination, e.g., to inhibit wild-type influenza virus replication, to serve as an immunostimulatory agent, and/or as attenuated vaccine backbones. In one embodiment, the genomes of the DIPs provide for inhibitory activity, producing a dual effect in which both the RNA itself and the encoded protein coordinate to interfere with replication. Thus, the ability of DIPs to block replication of WT virus provides for a treatment for infection, use as an immunostimulatory agent, and as attenuated viruses for vaccination. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495338 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/16132 (20130101) C12N 2760/16232 (20130101) C12N 2760/16332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228981 | Wimmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eckard Wimmer (East Setauket, New York); Steve Skiena (Setauket, New York); Steffen Mueller (Kings Point, New York); Bruce Futcher (Setauket, New York); Dimitris Papamichail (Newtown, Pennsylvania); John Robert Coleman (Blauvelt, New York); Jeronimo Cello (Port Jefferson, New York) |
| ABSTRACT | This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/13 (20130101) A61K 39/145 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2720/12361 (20130101) C12N 2740/15061 (20130101) C12N 2760/16061 (20130101) C12N 2760/16121 (20130101) C12N 2760/16134 (20130101) C12N 2760/16162 (20130101) C12N 2770/20061 (20130101) C12N 2770/24161 (20130101) C12N 2770/32061 (20130101) C12N 2770/32621 (20130101) C12N 2770/32634 (20130101) C12N 2770/32661 (20130101) C12N 2770/32662 (20130101) C12N 2770/32671 (20130101) C12N 2770/32721 (20130101) C12N 2770/32761 (20130101) C12N 2770/32762 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228992 | Jantz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Derek Jantz (Durham, North Carolina); Michael G. Nicholson (Chapel Hill, North Carolina); James Jefferson Smith (Morrisville, North Carolina) |
| ABSTRACT | Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/352037 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/005 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4703 (20130101) C07K 2319/09 (20130101) C07K 2319/71 (20130101) C07K 2319/80 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228994 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | James Jefferson Smith (Morrisville, North Carolina); Derek Jantz (Durham, North Carolina); Homme W. Hellinga (Durham, North Carolina) |
| ABSTRACT | Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472881 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 15/905 (20130101) C12N 15/907 (20130101) C12N 15/8213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229000 | TSOURKAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); AlphaThera LLC (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); AlphaThera LLC (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Andrew TSOURKAS (Bryn Mawr, Pennsylvania); Wendy YU (West Windsor, New Jersey); Wendy Yu (San Mateo, California); Per-Åke Nygren (EKERÖ, Sweden) |
| ABSTRACT | The present disclosure provides compositions and methods for site-specific labeling of antibodies by proximity-based sortase-mediated ligation. The ligation method utilizes a non-canonical isopeptide ligation reaction catalyzed by newly identified variants of S. aureus sortase A. An antibody binding domain (e.g., protein A or protein G) is fused to the variants of SrtA to bring the enzyme into close proximity of an antibody, thereby significantly increases the efficiency of isopeptide bond formation. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559333 |
| CURRENT CPC | Peptides C07K 14/315 (20130101) C07K 16/22 (20130101) C07K 16/32 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Enzymes C12Y 304/2207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229011 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhou DONG (Dublin, Ohio); Bin LI (Columbus, Ohio) |
| ABSTRACT | The present disclosure generally relates to genome editing systems and methods and compounds and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing systems. Disclosed herein are modified nucleic acids that modulate the activity of genome editing. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543827 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/113 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/3521 (20130101) C12N 2310/3533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229012 | Beisel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase Lawrence Beisel (Raleigh, North Carolina); Scott Patrick Collins (Raleigh, North Carolina) |
| ABSTRACT | h The present disclosure provides compositions, methods, and systems related to template-mediated genome editing and modification. In particular, the present disclosure provides novel genome modification technology involving site-specific chemical modification of a nucleotide to introduce a replication-blocking lesion. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 18/546378 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229014 | Chory et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Emma J. Chory (Boston, Massachusetts); Kevin Esvelt (Newton, Massachusetts); Vainavi Mukkamala (West Windsor, New Jersey) |
| ABSTRACT | The invention, in part, includes systems and methods for conducting and optimizing continuous evolution of molecules capable of forming multi-body complexes, such as but not limited to evolution of molecules capable of forming three- and four-molecule multi-body complexes. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/408191 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) C12N 15/1058 (20130101) Original (OR) Class C12N 15/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229023 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The University of Tokyo (Tokyo, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Hiroshi Nishimasu (Sibuya-Ku, Japan); Kazuki Kato (Tokyo, Japan); Cian Schmitt-Ulms (Cambridge, Massachusetts); Kaiyi Jiang (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are methods of RNA-triggered protein cleavage by the CRISPR Cas7-11-Csx29 complex. A guide RNA specifically hybridizes to a RNA target, and Csx29 cleaves Csx30 when Cas7-11:Csx29 complex binds to the target RNA. |
| FILED | Wednesday, August 16, 2023 |
| APPL NO | 18/234690 |
| CURRENT CPC | Peptides C07K 2319/33 (20130101) C07K 2319/50 (20130101) C07K 2319/60 (20130101) C07K 2319/61 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/50 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) Enzymes C12Y 304/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229029 | COREY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | David COREY (Dallas, Texas); Liande LI (Dallas, Texas) |
| ABSTRACT | Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/471280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229031 | Mouradian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | M. Maral Mouradian (Princeton, New Jersey); Eunsung Junn (East Brunswick, New Jersey) |
| ABSTRACT | MicroRNAs, or mimics thereof, for treating a subject suffering from nervous system dysfunction are described. Pharmaceutical compositions, viral vectors or viral particles, and nanoparticles comprising these microRNAs, or mimics thereof, are described. Methods of using these microRNAs, or mimics thereof, pharmaceutical compositions comprising the microRNAs, viral vectors, or nanoparticles are also described herein. These compositions and methods of use will provide novel therapies for patients suffering nervous system dysfunction, including but not limited to alpha-synucleinopathies and SCI. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484001 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229034 | Morris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Morris (Duarte, California); Alicia Davis (Duarte, California); Tristan Scott (Pasadena, California); Roslyn Ray (Monrovia, California); Denis O'Meally (Duarte, California) |
| ABSTRACT | Provided herein are, inter alia, lipid nanoparticles, lipid nanoparticles comprising nucleic acids encapsulated therein, pharmaceutical compositions comprising lipid nanoparticles which comprise nucleic acids encapsulated therein, and methods of treating diseases, such as coronavirus infections (e.g., SARS-CoV-2, SARS-CoV-2, MERS-CoV), COVID, and MERS. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/285964 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 47/6925 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229043 | SUSZTAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katalin SUSZTAK (Princeton, New Jersey); Dhanunjay MUKHI (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing a chronic kidney disease and complications thereof. The method for treating CKD comprise administering a therapeutically effective amount at least one selected from the group consisting of DPEP1 inhibitor, a CASP9 inhibitor, a ACSS2 inhibitor, and a FASN inhibitor, or a salt, solvate, tautomer, enantiomer, diastereoisomer, geometric isomer, and/or any combination thereof, wherein administration prevents fibrosis and ferroptosis in the subject. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501859 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/502 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229066 | Chandran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kartik Chandran (Brooklyn, New York); Rohit K. Jangra (Shreveport, Louisiana); Maria Dieterle (Bronx, New York); Denise Haslwanter (Vienna, Austria) |
| ABSTRACT | Provided herein are recombinant vesicular stomatitis virus (rVSV) or rVSV vector comprising nucleic acid encoding the spike glycoprotein S of SARS-COV-2, compositions comprising such vectors or viruses, as well as screening methods, diagnostic methods, prophylactic and therapeutic methods using such vectors or viruses. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/094117 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/24143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229068 | Rabinowitz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NXGEN VECTOR SOLUTIONS, LLC (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph E. Rabinowitz (Philadelphia, Pennsylvania) |
| ABSTRACT | A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/366495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229072 | NAGARAJ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ram H. NAGARAJ (Aurora, Colorado); Rooban B. NAHOMI (Aurora, Colorado) |
| ABSTRACT | Gene therapy for a retinal disease, injury, or condition in a subject involves administering to the subject a pharmaceutical composition containing a recombinant adeno-associated viral vector encoding at least one heat shock protein, such as Hsp27. A recombinant adeno-associated viral vector can include a promoter sequence that induces production of a heat shock protein specifically in retinal ganglion cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The disclosed viral vector may be included in pharmaceutical compositions that may be administered intravitreally using an administration device. A single injection 10 may be therapeutically sufficient for treating various ocular conditions. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/547348 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229077 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Andrew Vito Anzalone (Cambridge, Massachusetts); James William Nelson (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The nucleotide change can include a single-nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to a strand of the targeted endogenous DNA sequence to be edited, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incorporated into the target DNA molecule. Also disclosed herein are various methods that leverage prime editing, including treating trinucleotide repeat contraction diseases, installing targeted peptide tags, treating prion disease through the installation of protection mutations, manipulating RNA-encoding genes for the installation of RNA tags for controlling the function and expression of RNA, using prime editing to construct sophisticated gene libraries, using prime editing to insert immunoepitopes into proteins, use of prime editing to insert inducible dimerization domains into protein targets, and delivery methods, among others. |
| FILED | Monday, December 12, 2022 |
| APPL NO | 18/064738 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1276 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229081 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhang (Ann Arbor, Michigan); Zhonggang Hou (Ann Arbor, Michigan); Renke Tan (Ann Arbor, Michigan); Ailong Ke (Ithaca, New York) |
| ABSTRACT | The present disclosure provides systems and methods of altering a nucleic acid sequence, which comprise an engineered Type I CRISPR/Cas system comprising Cas3 and Cas11. Particularly. the system and methods described herein use compact engineered CRISPR-Cas3 systems (e.g., Type I-C, Type I-B, or Type I-D) for genetic manipulations (e.g., in eukaryotic cells). |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563175 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229098 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghong RAO (936 Dennis Drive, California); Tingting DAI (Menlo Park, California); Jinghang XIE (Fremont, California); Ran MU (Stanford, California) |
| ABSTRACT | Caged luciferin-based probes become a luciferase substrate emitting bioluminescence upon β-lactamase/esterase activation. The inclusion of a cephalosporin moiety renders the probe capable of being used for the detection of a wide-range of β-lactamases and β-lactamase-expressing bacteria. Embodiments of a rapid high-throughput assay for the identification of β-lactamase-expressing bacteria is made possible by the use of such probes. In some embodiments the cephalosporin is substituted by a carbapenem moiety to generate carbapenem-caged luciferin carbapenem-cleavable probes capable of being used for the detection of a wide-range of carbapenem-expressing bacteria. Accordingly embodiments of a rapid high-throughput assay for the identification of carbapenem-expressing bacteria is made possible by the use of these probes. |
| FILED | Wednesday, May 18, 2022 |
| APPL NO | 18/560486 |
| CURRENT CPC | Heterocyclic Compounds C07D 501/18 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class C12Q 1/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229102 | Lee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Hee Lee (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure relates to materials and methods for spatial detection of nucleic acid in a tissue sample or a portion thereof. In particular, provided herein are materials and methods for detecting RNA so as to obtain spatial information about the localization, distribution or expression of genes in a tissue sample. In some embodiments, the materials and methods provided herein enable detection of gene expression in a single cell. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/343858 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229105 | Yeakley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joanne M. Yeakley (Encinitas, California); Bruce Seligmann (Tucson, California); Joel McComb (Rancho Santa Fe, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joanne M. Yeakley (Encinitas, California); Bruce Seligmann (Tucson, California); Joel McComb (Rancho Santa Fe, California) |
| ABSTRACT | Methods for detecting nucleic acid sequences, where attenuator oligonucleotides are provided to reduce the number of detection products resulting from highly abundant sequences. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858984 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229132 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona) |
| ABSTRACT | Provided herein are methods and systems for sensitive and multiplexed in situ analysis of samples such as biological samples using cleavable fluorescent streptavidin. In particular, provided herein are methods for multiplexed single-cell in situ biomolecule profiling in samples, including fixed or fresh tissues, and also allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/480850 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2563/131 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229148 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Baylor College of Medicine (Houston, Texas); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Northwestern University (Evanston, Illinois); The Johns Hopkins University (Baltimore, Maryland); United States Government as represented by the U.S. Department of Veterans Affairs (Washington, D. C., District of Columbia) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Baylor College of Medicine (Houston, Texas); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Northwestern University (Evanston, Illinois); The Johns Hopkins University (Baltimore, Maryland); United States Government as represented by the U.S. Department of Veterans Affairs (Washington, D.C., District of Columbia) |
| INVENTOR(S) | Jaegil KIM (Cambridge, Massachusetts); Gad GETZ (Boston, Massachusetts); Seth Paul LERNER (Houston, Texas); David KWIATKOWSKI (Boston, Massachusetts); Joshua MEEKS (Evanston, Illinois); Joaquim BELLMUNT (Cambridge, Massachusetts); David MCCONKEY (Baltimore, Maryland) |
| ABSTRACT | The present invention features methods for characterizing mutational profiles in patients with bladder cancer. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/388985 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229166 | Shalek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts); University of Mississippi Medical Center (Jackson, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Jose Ordovas-Montanes (Boston, Massachusetts); Carly Ziegler (Cambridge, Massachusetts); Sarah Glover (Jackson, Mississippi); Bruce Horwitz (Boston, Massachusetts); Vincent Miao (Cambridge, Massachusetts); Anna Owings (Jackson, Mississippi); Andrew Navia (Cambridge, Massachusetts); Ying Tang (Boston, Massachusetts); Joshua Bromley (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to stratifying and treating coronavirus infections based on intrinsic immune states. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 18/277612 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230316 | Harper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Danielle J. Harper (Somerville, Massachusetts); Benjamin J. Vakoc (Arlington, Massachusetts) |
| ABSTRACT | An optical coherence tomography system which is capable of operating in two or more optical bandwidth configurations for the purpose of trading off between high resolution imaging and high signal-to-noise ratio imaging, wherein the later enables deeper imaging depth. The system and associated methods allow for both high resolution, shallow penetration depth and low resolution, deep penetration depth optical coherence tomography imaging to be performed using a single light source. Methods and apparatus are described that allow a single system to dynamically switch between modes, or to operate in a hybrid mode that achieves a balance between resolution and SNR/depth of penetration. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573335 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02009 (20130101) G01B 9/02044 (20130101) G01B 9/02091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230526 | MAHALANABISH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aditya MAHALANABISH (Ithaca, New York); He HUANG (Ithaca, New York); Gennady SHVETS (Ithaca, New York) |
| ABSTRACT | A plasmonic nanostructure includes a dielectric substrate, a periodic array of dielectric pillars on the dielectric substrate; and, on each dielectric pillar of the periodic array, a respective conductive layer. Each dielectric pillar of the periodic array of dielectric pillars is between the respective conductive layer and the dielectric substrate. A method for imaging a cell includes reflecting an optical beam off the plasmonic nanostructure. The plasmonic nanostructure has biological cells adhered thereto. The method also includes collecting the reflected optical beam with an optical detector. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409557 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3563 (20130101) Original (OR) Class G01N 33/4833 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230627 | Birnbaum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael Birnbaum (Arlington, Massachusetts); Connor Dobson (Sommerville, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458657 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/4748 (20130101) C07K 14/5437 (20130101) C07K 14/70532 (20130101) C07K 14/70539 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/035 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15045 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230628 | VUNJAK-NOVAKOVIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordana VUNJAK-NOVAKOVIC (New York, New York); Sharon FLEISHER (New York, New York); Manuel TAMARGO (Miami, Florida); Trevor Ray NASH (New York, New York); Robert WINCHESTER (New York, New York); Laura GERALDINO-PARDILLA (Ardsley, New York) |
| ABSTRACT | Provided are a system and method to culture human cardiac muscle tissues in a bioreactor comprising a plurality of culture wells arranged linearly between two carbon electrodes that are exposed within each well; and two horizontal parallel flexible pillars extending from each well wherein the pillars in each well are configured to suspend an engineered tissue. Also provided is method for diagnosing myocarditis in a subject by analyzing human cardiac muscle tissues cultured in the bioreactor in the presence of blood serum or antibodies from the subject. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431269 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2537/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class G01N 2800/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230634 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leidong Mao (Watkinsville, Georgia); Yang Liu (Athens, Georgia) |
| ABSTRACT | The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382849 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2200/0647 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1484 (20130101) G01N 33/54366 (20130101) Original (OR) Class G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230641 | Tsokos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George C. Tsokos (Boston, Massachusetts); Rhea Bhargava (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods of identifying and/or diagnosing an active lupus nephritis (LN) flare in a subject, the method comprising obtaining a sample from the subject; isolating cells from the urine sample; and determining a level of expression of calcium/calmodulin dependent protein kinase IV (CaMK4), IL-23, IL-17 receptor, and/or arginase 1, wherein an increased level of expression of CaMK4, IL-23, and/or IL-17 receptor as compared to a control or a decreased level of expression of arginase 1 as compared to a control indicates an active lupus nephritis (LN) flare in the subject. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/550008 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/007 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2333/54 (20130101) G01N 2333/912 (20130101) G01N 2800/104 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230646 | Chaudhary |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Preet M. Chaudhary (Toluca Lake, California) |
| ABSTRACT | Provided herein are methods for detecting an antigen or for detecting expression of a chimeric antigen receptor (CAR). The methods include obtaining a sample from a subject, contacting the sample with a fusion protein comprising a reporter fused to a single chain antibody specific to the antigen or fused to an extracellular domain of an antigen targeted by the CAR or fused to Protein L and assaying the activity of the reporter, wherein presence of reporter activity or increase in reporter activity relative to a reference value is indicative of presence of the antigen or presence of the expression of the chimeric antigen receptor in the sample. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/449154 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 16/2827 (20130101) C07K 16/2866 (20130101) C07K 16/2878 (20130101) C07K 16/2887 (20130101) C07K 16/2896 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/43 (20130101) C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/581 (20130101) G01N 33/5023 (20130101) G01N 33/5044 (20130101) G01N 33/56966 (20130101) G01N 33/56972 (20130101) Original (OR) Class G01N 2333/72 (20130101) G01N 2333/70503 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230664 | Clave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CZ BIOHUB SF, LLC (San Francisco, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xavier Rovira Clave (Stanford, California); Alexandros Panagiotis Drainas (Stanford, California); Sizun Jiang (Stanford, California); Garry P. Nolan (Stanford, California); Julien Sage (Stanford, California) |
| ABSTRACT | The present disclosure provides methods for determining the presence of at least one biomolecule in a sample. The present disclosure further provides methods for determining the presence of a coronavirus antibody in a sample. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 18/270277 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 33/54313 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230665 | SMITH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. SMITH (White Bluff, Tennessee) |
| ABSTRACT | The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/497432 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/35 (20130101) A61K 45/06 (20130101) Peptides C07K 16/16 (20130101) C07K 16/18 (20130101) C07K 2317/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/686 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 2333/43526 (20130101) G01N 2333/43582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230666 | Grasberger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); INSTITUTE FOR SYSTEMS BIOLOGY (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Helmut Grasberger (Ann Arbor, Michigan); John Y. Kao (Ann Arbor, Michigan); Andrew Magis (Seattle, Washington) |
| ABSTRACT | The present invention relates to methods for detecting disease-relevant microbial colonization of the gut mucosal surface (proinflammatory mucosal dysbiosis) prior to onset of overt inflammation by measuring a level of interleukin 17C (IL17C) and other microinflammation markers in a biological sample from a subject and treating and/or preventing intestinal inflammation if these markers are elevated. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/284033 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6874 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6863 (20130101) Original (OR) Class G01N 2333/54 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230669 | Laurie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon W. Laurie (Charlottesville, Virginia) |
| ABSTRACT | The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/18 (20130101) A61K 38/1709 (20130101) Peptides C07K 14/475 (20130101) Enzymes C12Y 302/01166 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/573 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/924 (20130101) G01N 2333/4706 (20130101) G01N 2333/4722 (20130101) G01N 2333/4728 (20130101) G01N 2333/70596 (20130101) G01N 2800/16 (20130101) G01N 2800/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230679 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Newomics Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daojing WANG (Moraga, California); Pan MAO (Milpitas, California); Weimin NI (Palo Alto, California) |
| ABSTRACT | The present disclosure provides methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample. The methods may involve microflow liquid chromatography (LC) coupled with mass spectrometry (MS) to rapidly quantitate biomarkers in a sample and identify the likelihood of the sample being positive for a disease or condition. |
| FILED | Tuesday, July 11, 2023 |
| APPL NO | 18/220789 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230681 | MARTINEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Briana MARTINEZ (Tempe, Arizona); Sarah STABENFELDT (Tempe, Arizona); Christopher DIEHNELT (Chandler, Arizona); Nicholas STEPHANOPOULOS (Scottsdale, Arizona); Crystal WILLINGHAM (Tempe, Arizona); Amanda WITTEN (Phoenix, Arizona); Kendall LUNDGREEN (Gilbert, Arizona) |
| ABSTRACT | A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences. |
| FILED | Tuesday, October 03, 2023 |
| APPL NO | 18/480489 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230683 | GENDELMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University Of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University Of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Howard GENDELMAN (Omaha, Nebraska); R. Lee MOSLEY (Omaha, Nebraska); Mai MOSTAFA (Omaha, Nebraska); Katherine OLSON (Omaha, Nebraska) |
| ABSTRACT | Provided are methods for monitoring the progression of Parkinson's Disease, and methods for monitoring or determining the effectiveness of therapeutics for the treatment of Parkinson's Disease, as well as methods for treatment thereof, by assessing one or more biomarkers, such as NF-κB and/or calcineurin. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 18/560365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 38/193 (20130101) A61K 38/1709 (20130101) A61K 38/2278 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2333/916 (20130101) G01N 2333/4703 (20130101) G01N 2800/52 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230809 | JIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | TAO JIN (WEXFORD, Pennsylvania); JULIUS CHUNG (PITTSBURGH, Pennsylvania) |
| ABSTRACT | A method for chemical exchange saturation transfer (CEST) MRI using an average saturation efficiency filter (ASEF)/adjustment of rotation and saturation effects (AROSE) includes: applying a first RF pulse train including a high duty cycle, the first RF pulse causing magnetization of exchangeable protons based on saturation and/or rotation effects, transferred to a water pool of a target structure; discontinuing application of the first RF pulse train; acquiring a first water MR signal; applying a second RF pulse train including a low duty cycle, the second RF pulse train causing magnetization of the target molecules based at least in part on saturation transfer and either minimizing rotation transfer with bipolar pulses or adjusting rotation transfer with selected flip angles; discontinuing application of the second RF pulse train; acquiring a second water MR signal; and generating ASEF/AROSE signal representing a difference between the first and second water MR signals. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/561126 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) G01R 33/4828 (20130101) G01R 33/5605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230810 | Shih et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shu-Fu Shih (Los Angeles, California); Holden H. Wu (Los Angeles, California) |
| ABSTRACT | A method for generating magnetic resonance imaging (MRI) quantitative parameter maps includes receiving at least one multi-contrast magnetic resonance (MR) image of a subject, providing the image to an artifact suppression deep learning network of a two-stage deep learning network and generating at least one multi-contrast MR image with suppressed undersampling artifacts using the artifact suppression deep learning network. The method further includes providing the at least one multi-contrast MR image with suppressed undersampling artifacts to a parameter mapping deep learning network of the two-stage deep learning network, generating at least one quantitative MR parameter map and generating an uncertainty estimation map for the at least one quantitative MR parameter map using the parameter mapping deep learning network. The method further includes displaying at least one multicontrast MR image with suppressed undersampling artifacts, at least one quantitative MR parameter map, and the corresponding uncertainty estimation map on a display. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/554397 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4828 (20130101) G01R 33/5608 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230813 | Lustig et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shimon M. Lustig (Moraga, California); Suma Mandayam Anand (Berkeley, California); Alan Dong (San Francisco, California) |
| ABSTRACT | A method of sensing motion in an MRI scanner includes transmitting at least two tones having different frequencies, using intermodulation to combine the two tones, transmitting the two tones as a combined signal during an MRI scan of a patient, receiving the combined signal using a receiver in the MRI scanner, demodulating the combined signal to produce a demodulated signal, and analyzing the demodulated signal to detect motion of the patient during the MRI scan. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/546411 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3621 (20130101) G01R 33/56509 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230881 | ADIB et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Fadel ADIB (Cambridge, Massachusetts); Laura Noelle DODDS (Cambridge, Massachusetts); Aline EID (Ann Arbor, Michigan); Isaac S. PERPER (Medford, Massachusetts) |
| ABSTRACT | A handheld system radio frequency identification (RFID) system for fine-grained RFID localization of an RFID target. Also disclosed is a mechanism for localizing RFID targets at all orientations through software-controlled polarization of two LP antennas. The system may detect an RFID target using a generated circularly polarized (CP) RF signal and accurately localize the RFID target using a generated linearly polarized (LP) signal. The disclosed systems and techniques discover and localize RFID concurrently and regardless of RFID target orientation. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505355 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/75 (20130101) Original (OR) Class G01S 13/867 (20130101) Antennas, i.e Radio Aerials H01Q 21/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233091 | Huber et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan R. Huber (Saint Peter, Minnesota); Shuai Leng (Rochester, Minnesota); Andrew D. Missert (Rochester, Minnesota); Lifeng Yu (Byron, Minnesota); Cynthia H. McCollough (Byron, Minnesota) |
| ABSTRACT | A neural network is trained and implemented to simultaneously remove noise and artifacts from medical images using a Generalized noise and Artifact Reduction Network (“GARNET”) method for training a convolutional neural network (“CNN”) or other suitable neural network or machine learning algorithm. Noise and artifact realizations from phantom images are used to synthetically corrupt images for training. Corrupted and uncorrupted image pairs are used for training GARNET. Following the training phase, GARNET can be used to improve image quality of routine medical images by way of noise and artifact reduction. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 18/546374 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 5/60 (20240101) Original (OR) Class G06T 5/70 (20240101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10116 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20224 (20130101) G06T 2207/30004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233093 | NOVIKOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DMITRY NOVIKOV (New York, New York); ELS FIEREMANS (New York, New York); Hong-Hsi LEE (Boston, Massachusetts) |
| ABSTRACT | Exemplary systems, methods and computer arrangement for decorrelating and removing noise, and/or for removing Gibbs ringing data from at least one image can be provided. In one example, there can be a procedure for receiving information related to the at least one image; a procedure for producing the at least one image based on the determination if the noise is decorrelated; a procedure to remove the noise from the at least one image; a procedure for detecting an oscillation pattern from at least one edge of a measured portion of k-space associated with the information; and a procedure for removing the Gibbs ringing artifact from the information based on the detected oscillation pattern. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 18/288900 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 5/70 (20240101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/10104 (20130101) G06T 2207/20182 (20130101) G06T 2207/20221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233861 | Townshend et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Raphael Townshend (Stanford, California); Stephan Eismann (Stanford, California); Andrew Watkins (Stanford, California); Rhiju Das (Palo Alto, California); Ron O. Dror (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods to determine RNA structure and uses thereof. Many embodiments utilize one or more machine learning models to determine an RNA structure. In various embodiments, the machine learning model is trained using experimentally determined RNA structures. Certain embodiments identify one or more ligands or drugs that bind to an RNA structure, which can be used to treat an individual for a disease, disorder, or infection. Various embodiments determine structure of other molecules, including DNA, proteins, small molecules, etc. Further embodiments determine interactions between multiple molecules and/or molecule types (e.g., RNA-RNA interactions, RNA-DNA interactions, DNA-protein interactions, etc.) |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/562693 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/10 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233873 | Ward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew B. Ward (San Diego, California); Aleksandar Antanasijevic (San Diego, California); Charles Bowman (San Diego, California); Christopher Cottrell (Poway, California); Gabriel Ozorowski (San Diego, California); Robert Kirchdoerfer (Fitchburg, Wisconsin) |
| ABSTRACT | Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 18/547705 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234116 | MARKOSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Volatylix, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth A. MARKOSKI (Hudson, Massachusetts); Erkinjon G. NAZAROV (Tampa, Florida); Clayton J. MORRIS II (Norfolk, Massachusetts) |
| ABSTRACT | An integrated oscillating field ion spectrometry device includes an ionization segment, filtering segment, and detection segment arranged in order. The filtering segment is located after the ionization segment and the detection segment is located after the filtering segment in the carrier gas flow direction. The ionization segment includes an ionizing tool and ionization region electrodes. The carrier gas moves material vapor through the ionizing tool to ionize the material vapor. Two parallel filter electrodes of the filtering segment that receive first DC voltages of opposite polarity and an RF oscillating voltage, filter ions from the carrier gas. Two parallel detector electrodes in the detection segment that are connected to a detection system receive second DC voltages. Ion guidance electrodes surround a periphery of the detector electrodes. The DC voltages and the RF oscillating voltage are selected to optimize detection of the specific ions of interest for a particular application. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/150645 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) Original (OR) Class H01J 49/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240225536 | Viswanath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satish E. Viswanath (Beachwood, Ohio); Florian Rieder (Shaker Heights, Ohio); Prathyush Chirra (Cleveland, Ohio); Joseph Sleiman (Pittsburgh, Pennsylvania); Namita Sharma Gandhi (Chagrin Falls, Ohio); Ilyssa Gordon (Beachwood, Ohio) |
| ABSTRACT | The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including accessing an imaging data set having one or more radiological images of a patient having Crohn's disease, the one or more radiological images including one or more intestinal strictures; identifying a plurality of determinative features from within the one or more intestinal strictures in the one or more radiological images, the plurality of determinative features being associated with one or more pathological features used to identify inflammation or fibrosis within an intestinal stricture; and applying a machine learning model to the plurality of determinative features to identify an extent of inflammation or fibrosis within the one or more intestinal strictures. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971065 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4255 (20130101) A61B 5/4842 (20130101) Original (OR) Class A61B 5/7264 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/40 (20130101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/30028 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225561 | Weimer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Erich Weimer (Arlinton, Virginia); Steven Russell Messé (Wynnewood, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for detecting stroke by monitoring of upper limb movements. In some examples, a method for detecting stroke includes receiving, at a stroke detector implemented on at least one processor, movement data from an accelerometer attached to an upper limb of a patient for a period of time. The method includes analyzing, at the stroke detector, the movement data using a test statistic robust to motion distribution covariate shift to enable passive monitoring of the patient. The method includes outputting, at the stroke detector, an alarm signal in response to detecting a stroke using the movement data. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/563707 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/11 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/6824 (20130101) A61B 5/7207 (20130101) A61B 5/7282 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225745 | Brattain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); US Army Institute of Surgical Research (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Brattain (Lexington, Massachusetts); Brian A. Telfer (Lincoln, Massachusetts); Matthew Johnson (Medford, Massachusetts); Lars Gjesteby (Maynard, Massachusetts); Joshua Werblin (Boston, Massachusetts); Gregory R. Dion (San Antonio, Texas); Ronit E. Malka (San Antonio, Texas); Shawn Moynihan (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for identification of anatomical landmarks from image data. The image analysis provides for guidance for insertion of a cannulation system into an airway of a subject which may be accomplished by a non-expert based upon the guidance provided. The system further enables a single person to perform the cannulation rather than the typical 2 or more people. The guidance may include an indicator or a mechanical guide to guide a user for inserting the cannulation system into a subject to penetrate the airway of interest. |
| FILED | Saturday, July 01, 2023 |
| APPL NO | 18/217555 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/0841 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 2034/2063 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/01 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225764 | Behrens et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael R. Behrens (Loudon, New Hampshire); Warren RUDER (West Mifflin, Pennsylvania) |
| ABSTRACT | A system for controlling a magnetic microdevice to move within a fluidic environment, comprising an imaging device, a multi-axis electromagnet for generating a magnetic field based on sinusoidal current signals, and a controller for controlling the multi-axis electromagnet based on a machine-learning model, and wherein for training the machine-learning model, the controller is configured to receive images of the fluidic environment and the magnetic microdevice from the imaging device, determine a state comprising position information of the magnetic microdevice based on the images, calculate a measure of performance associated with a first set of sinusoidal current signals previously inputted to the multi-axis electromagnet, wherein the calculated measure of performance is used to adjust parameters of the machine-learning model, and generate based on the position information and the first set of sinusoidal current signals using the machine-learning model, a second set of sinusoidal current signals as inputs for the multi-axis electromagnet. |
| FILED | Wednesday, March 20, 2024 |
| APPL NO | 18/610786 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/72 (20160201) A61B 34/73 (20160201) Original (OR) Class A61B 2034/731 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/038 (20130101) G01R 33/385 (20130101) Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) Image Data Processing or Generation, in General G06T 7/70 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225940 | Asbeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Alan Thomas Asbeck (Cambridge, Massachusetts); Ye Ding (Cambridge, Massachusetts); Robert Joseph Dyer (Cambridge, Massachusetts); Ignacio Galiana Bujanda (Cambridge, Massachusetts); Arnar Freyr Larusson (Cambridge, Massachusetts); Brendan Thomas Quinlivan (Cambridge, Massachusetts); Kai Schmidt (Cambridge, Massachusetts); Diana Wagner (Cambridge, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts); Michael Wehner (Cambridge, Massachusetts) |
| ABSTRACT | In at least one aspect, there is provided a system for generating force about one or more joints including a soft exosuit having a plurality of anchor elements and at least one connection element disposed between the plurality of anchor elements. The system also includes at least one sensor to determine a force the at least one connection element or at least one of the plurality of anchor elements and to output signals relating to the force, at least one actuator configured to change a tension in the soft exosuit and at least one controller configured to receive the signals output from the at least one sensor and actuate the at least one actuator responsive to the received signals. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880409 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/149 (20130101) A61H 2201/164 (20130101) A61H 2201/165 (20130101) A61H 2201/501 (20130101) A61H 2201/1215 (20130101) A61H 2201/1238 (20130101) A61H 2201/1246 (20130101) A61H 2201/1261 (20130101) A61H 2201/1481 (20130101) A61H 2201/1628 (20130101) A61H 2201/1652 (20130101) A61H 2201/1664 (20130101) A61H 2201/1671 (20130101) A61H 2201/5002 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5064 (20130101) A61H 2201/5069 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2201/5097 (20130101) A61H 2230/60 (20130101) A61H 2230/605 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226039 | BEG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amer BEG (Tampa, Florida); Xiaoqing YU (Tampa, Florida) |
| ABSTRACT | Disclosed herein is a method for treating a solid tumor in a subject that involves assaying a sample from the subject for expression of two or more Histone deacetylases (HDACs); determining a response score from the expression of the two or more HDACs, wherein the response score predicts whether the subject will respond to combination immunotherapy and HDAC inhibitor therapy; and administering to the subject a therapeutically effective amount of a combination of immunotherapy and an HDAC inhibitor. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563581 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226383 | ALVAREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Theradaptive, Inc. (Frederick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis ALVAREZ (Lexington, Maryland); Todd HEIL (Mt. Airy, Maryland) |
| ABSTRACT | The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses there e.g., in treating a condition in a subject in need thereof. The devices may be coated with therapeutic agents, such as those that promo bone growth, and/or seeded with cells to generate devices for use in tissue replacement and grafting. |
| FILED | Wednesday, February 23, 2022 |
| APPL NO | 18/547668 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/52 (20170801) A61K 47/593 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/38 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226614 | Welch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Army (Aberdeen Proving Ground, Maryland) |
| ASSIGNEE(S) | US Army (Aberdeen Proving Grounds, Maryland) |
| INVENTOR(S) | Lauretta Welch (Baltimore, Maryland); Stephanie Broce (Salem, Virginia); Lynn Anderson (Chelmsford, Massachusetts) |
| ABSTRACT | The protective headwear and garment assembly/system facilitates the formation of a secure interface/connection/fit between the protective headwear system and (preferably) a gas mask that is intended to be worn with the garment assembly. The system includes a tensioner system that is configured to ensure a tight, secure fit between a (preferably) neoprene facial seal component of the protective headwear, and the gas mask. The system also includes a tightening element to securely fit the protective headwear to the neck and body of the user. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494589 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 17/04 (20130101) A62B 17/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226846 | Rubenstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Mitchell H Rubenstein (Beavercreek, Ohio); Patrick Lewis (Alburquerque, New Mexico) |
| ABSTRACT | A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615536 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/262 (20130101) B01J 20/282 (20130101) B01J 20/283 (20130101) B01J 20/285 (20130101) B01J 2220/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) G01N 30/93 (20130101) G01N 30/8665 (20130101) G01N 2030/008 (20130101) G01N 2030/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226950 | AMASSIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina); North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Aram AMASSIAN (Raleigh, North Carolina); Nathaniel R. WOODWARD (Raleigh, North Carolina); Boyu GUO (Raleigh, North Carolina) |
| ABSTRACT | Spin coating systems and methods. In one aspect, a spin coater assembly is provided. The spin coater assembly includes a spinner configured for receiving a substrate thereon, a plurality of material dispensers, an arm assembly configured to selectively position one of the plurality of material dispensers over the substrate, and a controller in communication with each of the spinner, the plurality of material dispensers, and the arm assembly. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236256 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 11/08 (20130101) Original (OR) Class Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227061 | Dapino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcelo Dapino (Columbus, Ohio); Leon Headings (Columbus, Ohio); Ningxiner Zhao (Columbus, Ohio); Suresh Babu (Knoxville, Tennessee); Michael Pagan (Atlanta, Georgia); Steven Zinkle (Knoxville, Tennessee) |
| ABSTRACT | A method of welding a first layer of Ti alloy to a second layer of Ti alloy. The method includes disposing a metallic interlayer onto a first layer of Ti alloy, disposing the second layer of Ti alloy onto the metallic interlayer such that the metallic interlayer is disposed between the first layer of Ti alloy and the second layer of Ti alloy, and applying a horn of an ultrasonic device to the second layer of Ti alloy to weld the first layer of Ti alloy to the second layer of Ti alloy to form a welded material. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/374434 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/10 (20130101) Original (OR) Class B23K 2103/14 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/002 (20130101) C22F 1/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228030 | Mueller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Douglas Robert Mueller (Coppell, Texas); Jason DeWitt McPeak (Weatherford, Texas); Mark Alan Przybyla (Keller, Texas) |
| ABSTRACT | A drive system for a rotorcraft includes first and second gearbox assemblies and a lubrication assembly. The lubrication assembly includes first and second lubrication systems and a valve connected between the first and second lubrication systems such that when the valve is in a first position, a test mode of operation of the lubrication assembly is enabled and when the valve is in a second position, a normal mode of operation of the lubrication assembly is enabled. The lubrication assembly also includes a valve control unit operable to instruct the valve to selectively move between the first position and the second position. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049181 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 29/0033 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/00 (20130101) Gearing F16H 57/0442 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228290 | Bulmer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Bulmer (Dayton, Ohio) |
| ABSTRACT | The present invention relates to articles comprising fullerene supramolecular crystals and/or amorphous fullerene agglomerations, as well as carbon nanotubes (CNTs) and processes of making and using same. The disclosed articles have increased mechanical strength and flexibility while unexpectantly having an electrical conductivity that is similar to carbon nanotubes (CNTs) containing articles that do not contain fullerene supramolecular crystals and/or amorphous fullerene agglomerations. Such improved articles can be used in areas including cryogenics and aerospace. Applicants also provide an improved process of making the improved articles. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537136 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/152 (20170801) Original (OR) Class C01B 32/158 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/01 (20130101) C01P 2002/70 (20130101) C01P 2002/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228399 | Epshteyn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Albert Epshteyn (Potomac, Maryland); Zachary J. Huba (Oakland Park, Florida); Matthew Finn (Alexandria, Virginia) |
| ABSTRACT | A nanoparticle of a decomposition product of a transition metal aluminum hydride compound, a transition metal borohydride compound, or a transition metal gallium hydride compound. A process of: reacting a transition metal salt with an aluminum hydride compound, a borohydride compound, or a gallium hydride compound to produce one or more of the nanoparticles. The reaction occurs in solution while being sonicated at a temperature at which the metal hydride compound decomposes. A process of: reacting a nanoparticle with a compound containing at least two hydroxyl groups to form a coating having multi-dentate metal-alkoxides. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/614997 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 6/23 (20130101) C01B 6/243 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/02 (20130101) C01P 2002/72 (20130101) C01P 2002/86 (20130101) C01P 2002/88 (20130101) C01P 2002/89 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 43/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228468 | Bender et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron M. Bender (Spring Hill, Tennessee); Matthew Spock (Nashville, Tennessee); Trever R. Carter (Nashville, Tennessee); Melissa A. Korkmaz-Vaisys (Nashville, Tennessee); Logan A. Baker (Thompson's Station, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Craig W. Lindsley (Brentwood, Tennessee) |
| ABSTRACT | The present invention relates to (6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)benzamide (R2b is —C(O)N(RA1)(RA2) and N-(6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl) phenyl) carboxamide (R2b is —N(RB)C(O)RC) derivatives of formula (I) wherein (II) R2b is —C(O)N(RA1)(RA2) or —N(RB)C(O)RC as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for the treatment of neurodegenerative disorders, movement disorders or brain disorders, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. N-(4-(6-(((3aR,5s,6aS)-2-(2-fluorobenzyl)octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl) phenyl)acetamide (A1) (III). |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 18/553412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/50 (20130101) A61K 31/351 (20130101) A61K 31/501 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 237/12 (20130101) C07D 237/24 (20130101) C07D 309/06 (20130101) C07D 309/08 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228563 | NG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew H. NG (San Francisco, California); Matthew KIM (San Francisco, California); Hana EL-SAMAD (San Francisco, California) |
| ABSTRACT | Provided herein is a fusion protein comprising: (a) an extracellular domain comprising a first binding moiety that is capable of specifically binding to a first cell surface marker: (b) a transmembrane domain: and (c) an intracellular domain comprising: i. a first dimerization domain that specifically binds to a corresponding target dimerization domain in a target protein: and ii. a degradation domain, wherein the degradation domain is a degron or E3 ligase-recruiting domain. Protein circuits. cells and methods that make use of the fusion protein are also provided. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/278377 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228595 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Lei Peng (New Haven, Connecticut); Ping Ren (New Haven, Connecticut) |
| ABSTRACT | The present disclosure provides a set of high-throughput methods for rapid and efficient identification and generation of monoclonal antibodies. Also provided are highly potent human and humanized monoclonal antibodies and antigen-binding fragments and bispecific antibodies which are capable of binding to a wild-type or variant SARS-COV-2 spike protein receptor-binding domain (RBD), isolated nucleic acids and expression vectors encoding the antibodies and antigen-binding fragments and bispecific antibodies, cells comprising the nucleic acids and/or expression vectors, and methods for detecting, diagnosing, and/or neutralizing SARS-COV-2 and for treating at least one sign or symptom of a condition, disorder, or disease caused by SARS-COV-2 infection, including COVID-19. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/559559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 37/04 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20034 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228607 | Ji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Ji (Evanston, Illinois); Kehan Ren (Evanston, Illinois); Yang Mei (Evanston, Illinois) |
| ABSTRACT | The present invention provides methods of using an inhibitor of the IL-6 signaling pathway to inhibit disease progression in a subject with a high-risk myelodysplastic syndrome (MDS) or treat low blast count acute myeloid leukemia (AML). Methods for identifying therapeutics for preventing MDS to AML progression are also provided. |
| FILED | Wednesday, July 05, 2023 |
| APPL NO | 18/347541 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/715 (20130101) C07K 16/248 (20130101) Original (OR) Class C07K 16/2866 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228657 | Pastan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Ira H. Pastan (Chevy Chase, Maryland); Junxia Wei (Rockville, Maryland); Masanori Onda (Germantown, Maryland); Tapan Bera (Frederick, Maryland); Mitchell Ho (Urbana, Maryland) |
| ABSTRACT | Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/471137 |
| CURRENT CPC | Peptides C07K 14/21 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2866 (20130101) C07K 16/2878 (20130101) C07K 2317/31 (20130101) C07K 2317/73 (20130101) C07K 2317/94 (20130101) C07K 2317/569 (20130101) C07K 2317/624 (20130101) C07K 2319/33 (20130101) C07K 2319/50 (20130101) C07K 2319/55 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228945 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lynch (Durham, North Carolina); Jeovanna Rios (Durham, North Carolina) |
| ABSTRACT | Methods and microorganisms for improved malonyl-CoA flux and production of products having malonyl-CoA as a precursor. The methods comprise dynamically regulating, in a stationary phase of a method, a nitrogen regulatory protein. The methods may dynamically regulate more than one gene. |
| FILED | Tuesday, March 21, 2023 |
| APPL NO | 18/187102 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Original (OR) Class C12N 9/88 (20130101) C12N 15/52 (20130101) C12N 15/113 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229046 | Tracewell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cara Ann Tracewell (Walnut Creek, California); Alexander Glennon Shearer (San Francisco, California); Anupam Chowdhury (Emeryville, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of deoxyhydrochorismic acid and provides novel engineered microbial cells and cultures, as well as related deoxyhydrochorismic acid production methods. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/925593 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1085 (20130101) C12N 9/1205 (20130101) C12N 15/52 (20130101) Original (OR) Class Enzymes C12Y 205/01054 (20130101) C12Y 207/01071 (20130101) C12Y 402/03004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229090 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Yousong Ding (Gainesville, Florida); Ran Zuo (Gainesville, Florida) |
| ABSTRACT | The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529216 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0042 (20130101) C12N 9/0075 (20130101) C12N 15/62 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/227 (20130101) Original (OR) Class Enzymes C12Y 101/9901 (20130101) C12Y 106/02004 (20130101) C12Y 114/13039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230002 | Hess et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Enduralock, LLC (Lenexa, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold Hess (Leawood, Kansas); Deeptesh Selvaraj (Pitt Meadows, Canada); Kishan Srinivas Indrani (Lenexa, Kansas); Zoltan Szekely (Cypress, Texas); Caleb Grabill (Olathe, Kansas); Jonathan Poulter (Denver, Colorado) |
| ABSTRACT | A docking system for use with in-space structures includes a first connector attached to a first in-space structure and a second connector attached to a second in-space structure. The first connector includes a first housing that defines a recess. The second connector includes a second housing that is received within the recess of the first housing. The docking system also includes an engagement mechanism configured to secure the second housing in the recess. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409280 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 37/35 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/71 (20130101) H01R 13/533 (20130101) H01R 13/631 (20130101) H01R 13/635 (20130101) H01R 13/6683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230265 | GEISSELE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WHG PROPERTIES, LLC (North Wales, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. GEISSELE (Lower Gwynedd, Pennsylvania); Ralph E. DILEMMO (Norristown, Pennsylvania); Eric Binter (Sussex, New Jersey) |
| ABSTRACT | A firearm barrel is provided having a body defining an outer surface and a bore. The bore may define a rifling profile along at least a portion of a length of the barrel. The rifling profile may define a cross-sectional profile perpendicular to the length of the barrel at a location along the length of the barrel. The cross-sectional profile may include a plurality of arcuate portions and a plurality of linear portions. The cross-sectional profile may define a cross-sectional area defined by a Sporting Arms and Ammunition Manufacturers' Institute (SAAMI) standard rifling profile. Various embodiments may include firearms, assemblies, components, and methods associated with such firearms and firearm barrels. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152223 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230316 | Harper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Danielle J. Harper (Somerville, Massachusetts); Benjamin J. Vakoc (Arlington, Massachusetts) |
| ABSTRACT | An optical coherence tomography system which is capable of operating in two or more optical bandwidth configurations for the purpose of trading off between high resolution imaging and high signal-to-noise ratio imaging, wherein the later enables deeper imaging depth. The system and associated methods allow for both high resolution, shallow penetration depth and low resolution, deep penetration depth optical coherence tomography imaging to be performed using a single light source. Methods and apparatus are described that allow a single system to dynamically switch between modes, or to operate in a hybrid mode that achieves a balance between resolution and SNR/depth of penetration. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573335 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02009 (20130101) G01B 9/02044 (20130101) G01B 9/02091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230402 | Mann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Chris W. Mann (Austin, Texas); Kieran Lerch (Hood River, Oregon); Alexander P. Greis (Austin, Texas); Austin Ferrie (Happy Valley, Oregon) |
| ABSTRACT | An integral field spectral imager has a plurality of optical homogenizers. Each optical homogenizer is in-register with a corresponding different superpixel in a superpixel array and is configured to spatially homogenize incident EMR and to pass the spatially homogenized EMR to a spectral filter in an array of spectral filters, thence to the in-register, corresponding different superpixel. Baffles are included to maximize confinement of the spatially homogenized EMR passed by a single optical homogenizer to the in-register, corresponding different superpixel so as to minimize crosstalk between superpixels. Optical homogenizers and baffles are designed to produce a pattern of homogenized EMR on a superpixel, regardless of where incident EMR is received on an optical homogenizer. Methods for using embodiments of the spectral imager in a variety of spectral bands in the EMR spectrum enable determining spectral information about incident EMR. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406301 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/0411 (20130101) G01J 1/0429 (20130101) G01J 1/0437 (20130101) Original (OR) Class G01J 3/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230408 | MURRAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOSEPH B. MURRAY (Ellicott City, Maryland); Brandon Redding (University Park, Maryland); Matthew J. Murray (Alexandria, Virginia) |
| ABSTRACT | An apparatus includes a spectrometer receiving an optical input signal that includes an input optical spectrum. The spectrometer includes a fiber laser cavity pumped by a first optical replica of the optical input signal that generates stimulated Brillouin scattering traveling in a direction opposite to a direction of the optical input signal. The first optical replica of the optical input signal excites at least one lasing mode in the fiber laser cavity. The at least one lasing mode respectively includes at least one lasing mode frequency. The at least one lasing mode frequency is onset by a respective Brillouin frequency shift from the respective at least one input frequency. The spectrometer also includes an optical heterodyne receiver. The optical heterodyne receiver generates the electrical output signal. The spectrometer outputs a measurement of the input optical spectrum based on the respective Brillouin frequency shift and the at least one input frequency. |
| FILED | Friday, September 08, 2023 |
| APPL NO | 18/243728 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/12 (20130101) G01J 3/4412 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230419 | MOHAMMED et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammed Tharwat Hassan MOHAMMED (Tucson, Arizona); Dandan HUI (Tucson, Arizona); Husain ALQATTAN (Tucson, Arizona) |
| ABSTRACT | System and method configured for real-time, direct, all-optical methodology of measurement of a temporal profile of optical field. In one case, such measurement is carried out by recording electronic delay response of a target material system triggered by a strong driving optical field (in particular—by pulsed light with sub-femtosecond pulses containing a few cycles of optical field each). A corresponding all-optical metrological tool configured to operate with (sub-)femtosecond resolution. Demonstration of the on-demand sub-femtosecond electron motion control in solid-state with the use of synthesized waveforms of optical field. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/557871 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 11/00 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230458 | ZIEHL et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PAUL ZIEHL (IRMO, South Carolina); CASEY A. COLE (LAURENS, South Carolina) |
| ABSTRACT | Method and apparatus detect structural damage of structures using Acoustic Emission (AE) sensors. Using our method, structures can be monitored in real-time to predict damage level. This damage level assessment can be used to plan repairs and restorations of structures. Application can be used with concrete, and also applied to other materials such as composites. Predictive AE models may be tuned for determining structural damage zones, with the method extendable into any number of zones. An algorithm may be used in conjunction with decision tree filtering to use AE to predict structural damage zones, with the system able to perform analysis in real-time. |
| FILED | Friday, April 21, 2023 |
| APPL NO | 18/304457 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/025 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0464 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230492 | Michopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John G. Michopoulos (Washington, District of Columbia); Athanasios P. Iliopoulos (Bethesda, Maryland); John C. Steuben (Washington, District of Columbia); Benjamin Graber (College Partk, Maryland) |
| ABSTRACT | Methods and apparatuses for multiple degree-of-freedom fatigue testing of a specimen. The apparatus includes a first platform, a second platform, a plurality of actuator assemblies, a load cell, a mounting plate, a specimen support, a direct-strain imaging system, and a local sense and control system. Each actuator assembly includes a servo-control, a position encoder, and a piston that is constructed to move in a linear direction in accordance with the servo-control. Each piston is rotatably connected to the second platform. The load cell is connected to the second platform and constructed to output force measurements in three orthogonal directions and torque measurements about the three orthogonal directions. The mounting plate is constructed to hold a portion a specimen. The specimen support is constructed to hold another portion of the specimen. The direct-strain-imaging system includes a camera that is constructed to record a plurality of images of the specimen during fatigue testing. The local sense and control system constructed to receive: a loading specification, the force measurements and torque measurements from the load cell, and position information from each position encoder, and output control commands to each servo-control of the plurality of actuator assemblies based on the received loading specification. The control commands are updated in time in accordance with the position information from each position encoder and the force measurements and torque measurements from the load cell. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/383646 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/08 (20130101) Original (OR) Class G01N 3/068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230575 | Potyrailo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York); Shiyao Shan (Clifton Park, New York) |
| ABSTRACT | A sensor system is described with improved measurement accuracy that is achieved by reducing noise, baseline drift, or both based on processing a group of sensor element response signals. The response signals may be received in response to providing stimuli to the sensor element using different excitation frequencies over time. For example, the sensor circuitry may provide excitation signals to the sensing element with multiple excitation frequencies over time. The sensor system may include storage and processing circuitry to receive the response signals and to generate the correction values based on analyzing the received response signals. The sensor system may then provide adjusted response signals by reducing the noise, baseline drift, or both based on the correction values. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969428 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/227 (20130101) G01N 27/228 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230627 | Birnbaum et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael Birnbaum (Arlington, Massachusetts); Connor Dobson (Sommerville, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458657 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/4748 (20130101) C07K 14/5437 (20130101) C07K 14/70532 (20130101) C07K 14/70539 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/035 (20130101) C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15045 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230651 | Kiebish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BPGBIO, INC. (Framingham, Massachusetts); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); Windber Research Institute (Windber, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Andrew Kiebish (Millis, Massachusetts); Albert John Kovatich (Bethesda, Maryland); Punit Shah (Hopkington, Massachusetts); Niven Rajin Narain (Cambridge, Massachusetts); Rangaprasad Sarangarajan (Boylston, Massachusetts); Guisong Wang (Bethesda, Maryland); Jeffery A. Hooke (Bethesda, Maryland); Hai Hu (Windber, Pennsylvania); Jamie Leigh Campbell (Bethesda, Maryland); Mary L. Cutler (Bethesda, Maryland); Craig D. Shriver (Bethesda, Maryland) |
| ABSTRACT | Methods for prognosing the risk of progression in a ER-positive breast cancer (e.g., luminal B 1 breast cancer) subject are provided, such methods including the detection of levels of a variety of biomarkers prognostic of progression. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/286075 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) G01N 33/57415 (20130101) Original (OR) Class G01N 2333/976 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230849 | OELSLAGER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PETER J. OELSLAGER (Stafford, Virginia); Mathew J. Moody (Fredericksburg, Virginia) |
| ABSTRACT | A position-tracking apparatus includes a receiver, which includes a beam steerer oriented to receive a laser signal. The laser signal includes a modulated data signal, a carrier signal, and a tracking signal. The receiver includes a segmented photodiode in optical communication with the beam steerer, thereby receiving the laser signal. The segmented photodiode includes a plurality of active-area segments and a photodiode center. Each active-area segment of the plurality of active-area segments includes a peak tracking-signal power and/or a plurality of tracking-signal power minima, if the tracking signal is misaligned with the photodiode center. The apparatus includes a processor communicating with the beam steerer and the segmented photodiode. The processor is configured to determine an offset of the tracking signal from the photodiode center based on the peak tracking-signal power and/or the plurality of tracking-signal power minima and is configured to adjust the beam steerer based on the offset. |
| FILED | Wednesday, April 05, 2023 |
| APPL NO | 18/131068 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/493 (20130101) G01S 7/4816 (20130101) Original (OR) Class G01S 7/4972 (20130101) G01S 17/66 (20130101) Transmission H04B 10/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230946 | McGirr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Scott C McGirr (San Diego, California); Ronald J Wroblewski (San Diego, California) |
| ABSTRACT | The present invention relates to a remote tomography system. A filament system generates at least one plurality of plasma filaments. An electromagnetic radiation (EMR) system directs EMR towards the at least one plurality of plasma filaments such that the EMR reflects off of the at least one plurality of plasma filaments towards at least one target region. The EMR system is configured to receive EMR reflected from the at least one plurality of plasma filaments such that EMR reflecting from the at least one target region can be directed towards the EMR system. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152264 |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/005 (20130101) Original (OR) Class G01V 5/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232544 | LUU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (ROME, New York) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (ROME, New York) |
| INVENTOR(S) | Jonathan W. LUU (Xenia, Ohio); Kevin P. FENTON (Colorado Springs, Colorado); Steve SIMSKE (Fort Collins, Colorado) |
| ABSTRACT | An apparatus for automated safety data sheet (SDS) processing that translates the entire SDSs from numerous chemical vendors, and in various formats (.pdf, .doc, .txt, .jpg, .gif, .png, etc) to machine-encoded text by employing optical, RFID, and infrared scanning, reading and writing devices. The apparatus reads and assess documents as a human would; ensuring that the documents are compliant, ensuring reported values are within expected thresholds, and that there are no conflicts in hazardous material classification, and comparing to similar products for more environmentally friendly alternatives. The apparatus further employs a processor that computes meta-algorithms as trainable neural networks that allow the invention to “learn” and appropriately classify values and calculate statistical probabilities for output accuracy and precision. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832800 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/51 (20200101) Original (OR) Class G06F 40/205 (20200101) Image or Video Recognition or Understanding G06V 30/224 (20220101) G06V 30/1916 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232644 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajesh P.N. Rao (Seattle, Washington); Dimitrios C. Gklezakos (Seattle, Washington); Vishwas Sathish (Seattle, Washington) |
| ABSTRACT | An active predictive coding network (APCN) is a multi-level network which may break down larger problems into constituent parts. APCNs solve problems compositionally by composing solutions using sequences of previously learned solutions to sub-problems. Considering a pair of adjacent levels, the higher level network includes a state vector and an action vector as well as a state network and action network. At a higher-level ‘macrostep’ the state network updates the state vector and the action network updates the action vector and lower-level state and action networks are generated (or updated) based on the updated state and action vectors respectively. For a number of lower-level ‘microsteps’ the lower-level state network updates a lower-level state vector and the lower-level action network updates a lower-level action vector. The higher-level network may be updated based on the operation of the lower-level network. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/408173 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/096 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232718 | Seo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jae-sun Seo (Tempe, Arizona); Jian Meng (Tempe, Arizona); Li Yang (Tempe, Arizona); Deliang Fan (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Jae-sun Seo (Tempe, Arizona); Jian Meng (Tempe, Arizona); Li Yang (Tempe, Arizona); Deliang Fan (Tempe, Arizona) |
| ABSTRACT | A method of training a machine learning algorithm comprises providing a set of input data, performing transforms on the input data to generate augmented data, to provide transformed base paths into machine learning algorithm encoders, segmenting the augmented data, calculating main base path outputs by applying a weighting to the segmented augmented data, calculating pruning masks from the input and augmented data to apply to the base paths of the machine learning algorithm encoders, the pruning masks having a binary value for each segment in the segmented augmented data, calculating sparse conditional path outputs by performing a computation on the segments of the segmented augmented data, and calculating a final output as a sum of the main base path outputs and the sparse conditional path outputs. A computer-implemented system for learning sparse features of a dataset is also disclosed. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494330 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233560 | Baldwin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BigML, Inc. (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken Baldwin (Albany, Oregon); Rick Hangartner (Corvallis, Oregon); Jim Shur (Barcelona, Spain); Chee Sing Lee (Bangor, Maine); Poul Petersen (Corvallis, Oregon); Charlie Parker (Lake Bluff, Illinois); Francisco Martin (Corvallis, Oregon) |
| ABSTRACT | A machine learning system is provided that receives location information from one or more aircraft, determines a deviation of the actual aircraft flightpath from an expected flight path. The flight path may be determined based on a filed flight plan, one or more historical flight paths. The actual aircraft flightpath is scored with respect to the expected flight path and the score may be used to determine an anomalous condition. In some cases, an aircraft crossing a boundary creates the anomalous condition. The anomalous conditions may be used to create a flag or an alert to indicate further analysis may be required. Through machine learning algorithms, hundreds, thousands, or tens of thousands or more flights can be simultaneously tracked and analyzed for anomalous conditions. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154732 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Traffic Control Systems G08G 5/0026 (20130101) G08G 5/0043 (20130101) G08G 5/0082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233861 | Townshend et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Raphael Townshend (Stanford, California); Stephan Eismann (Stanford, California); Andrew Watkins (Stanford, California); Rhiju Das (Palo Alto, California); Ron O. Dror (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods to determine RNA structure and uses thereof. Many embodiments utilize one or more machine learning models to determine an RNA structure. In various embodiments, the machine learning model is trained using experimentally determined RNA structures. Certain embodiments identify one or more ligands or drugs that bind to an RNA structure, which can be used to treat an individual for a disease, disorder, or infection. Various embodiments determine structure of other molecules, including DNA, proteins, small molecules, etc. Further embodiments determine interactions between multiple molecules and/or molecule types (e.g., RNA-RNA interactions, RNA-DNA interactions, DNA-protein interactions, etc.) |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/562693 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/10 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234139 | Tadjer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Marko J. Tadjer (Vienna, Virginia); Joseph A. Spencer (Springfield, Virginia); Alan G. Jacobs (Rockville, Maryland); Hannah N. Masten (Alexandria, Virginia); James Spencer Lundh (Gaithersburg, Maryland); Karl D. Hobart (Alexandria, Virginia); Travis J. Anderson (Alexandria, Virginia); Tatyana I. Feygelson (Springfield, Virginia); Bradford B. Pate (Arlington, Virginia); Boris N. Feigelson (Springfield, Virginia) |
| ABSTRACT | A method for growing nanocrystalline diamond (NCD) on Ga2O3 to provide thermal management in Ga2O3-based devices. A protective SiNx interlayer is deposited on the Ga2O3 before growth of the NCD layer to protect the Ga2O3 from damage caused during growth of the NCD layer. The presence of the NCD provides thermal management and enables improved performance of the Ga2O3-based device. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/490878 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0262 (20130101) H01L 21/02304 (20130101) H01L 21/02527 (20130101) H01L 21/02565 (20130101) Original (OR) Class H01L 29/24 (20130101) H01L 29/785 (20130101) H01L 29/802 (20130101) H01L 29/7787 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234346 | LEVY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GlobalFoundries U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark D. LEVY (Williston, Vermont); Brett T. CUCCI (Colchester, Vermont); Spencer H. PORTER (Colchester, Vermont); Santosh SHARMA (Austin, Texas) |
| ABSTRACT | The present disclosure relates to semiconductor structures and, more particularly, to seal ring structures and methods of manufacture. The structure includes: a semiconductor substrate; a channel layer above the semiconductor substrate; a trench within the channel layer, extending to the semiconductor substrate; and a moisture barrier layer lining sidewalls and a bottom surface of the trench. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/095156 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/291 (20130101) H01L 23/585 (20130101) Original (OR) Class H01L 23/3178 (20130101) H01L 23/53295 (20130101) H01L 29/0657 (20130101) H01L 29/7786 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234533 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GlobalFoundries U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Santosh Sharma (Austin, Texas); Shesh Mani Pandey (Saratoga Springs, New York); Rajendran Krishnasamy (Essex Junction, Vermont) |
| ABSTRACT | Disclosed is a structure including a substrate and a transistor on the substrate. The transistor includes a barrier layer above the substrate and a multi-gate structure on the barrier layer. The multi-gate structure includes a primary gate and a secondary gate. The secondary gate has opposing sidewalls, opposing end walls and a top surface. The primary gate includes essentially vertically-oriented first portions on the barrier layer positioned laterally adjacent to opposing sidewalls, respectively, of the secondary gate. Optionally, the primary gate also includes an essentially horizontally-oriented second portion on the top surface of the secondary gate and/or essentially vertically-oriented third portions on the opposing end walls, respectively. The secondary gate can be a floating gate. Also disclosed is a method of forming the structure. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/152710 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/401 (20130101) H01L 29/475 (20130101) Original (OR) Class H01L 29/7786 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234556 | SON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Kyung-Ah SON (Moorpark, California); Jeong-Sun MOON (Moorpark, California); Hwa Chang SEO (Malibu, California) |
| ABSTRACT | A transition metal dichalcogenide (TMD) transistor includes a substrate, an n-type two-dimensional (2D) TMD layer, a metal source electrode, a metal drain electrode, and a gate dielectric. The substrate has a top portion that is an insulating layer, and the n-type 2D TMD layer is on the insulating layer. The metal source electrode, the metal drain electrode, and the gate dielectric are on the n-type 2D TMD layer. The metal gate electrode is on top of the gate dielectric and is between the metal source electrode and the metal drain electrode. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969232 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/024 (20130101) H01L 21/02381 (20130101) H01L 21/02387 (20130101) H01L 21/02568 (20130101) H01L 29/24 (20130101) H01L 29/45 (20130101) H01L 29/4908 (20130101) H01L 29/7606 (20130101) Original (OR) Class H01L 29/66969 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234574 | Salahuddin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeef Salahuddin (Walnut Creek, California); Ava Jiang Tan (Berkeley, California) |
| ABSTRACT | A ferroelectric field-effect transistor having an endurance exceeding 1012 cycles is disclosed. The ferroelectric field-effect transistor includes a substrate, a source disposed over a first region of the semiconductor substrate, a drain disposed over a second region of the substrate, wherein the second region is spaced apart from the first region. The ferroelectric field-effect transistor includes a channel made of a semiconductor material within a third region of the substrate that is between the first region and the second region. The ferroelectric field-effect transistor further includes a gate stack having an interfacial layer disposed over the channel, wherein the interfacial layer has a permittivity that is greater than 3.9, and a layer of ferroelectric material disposed over the interfacial layer. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/546807 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/78391 (20140902) Original (OR) Class Electronic Memory Devices H10B 51/30 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240234611 — INVERTED METAMORPHIC MULTIJUNCTION SOLAR CELLS HAVING A PERMANENT SUPPORTING SUBSTRATE
| US 20240234611 | Cornfeld et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | SolAero Technologies Corp. (Albuquerque, New Mexico) |
| INVENTOR(S) | Arthur Cornfeld (Albuquerque, New Mexico); Jeff Stainfeldt (Albuquerque, New Mexico) |
| ABSTRACT | A solar cell fabricated from a semiconductor growth substrate; that is sub sequentially removed a sequence of layers of semiconductor material grown on the semiconductor growth substrate forming the solar cell; a metal contact layer deposited over the sequence of layers; of a permanent supporting substrate being affixed directly over the metal contact layer and permanently bonded thereto. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432626 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/048 (20130101) H01L 31/184 (20130101) H01L 31/0304 (20130101) H01L 31/0725 (20130101) Original (OR) Class H01L 31/1844 (20130101) H01L 31/1848 (20130101) H01L 31/1856 (20130101) H01L 31/1892 (20130101) H01L 31/03046 (20130101) H01L 31/03048 (20130101) H01L 31/06875 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234779 | Tender et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonard M. Tender (Bethesda, Maryland); Ian Martens (New Orleans, Louisiana); Joel Wesson (Picayune, Mississippi); Joel P. Golden (Fort Washington, Maryland); Jeffrey M. Book (Slidell, Louisiana); Andrew Quaid (New Orleans, Louisiana) |
| ABSTRACT | A benthic microbial fuel cell device (BMFC), namely an anode in contact with organic matter on the seafloor and a cathode in contact with overlying seawater, creates a closed path through which electric current can flow. In a conventional such device, it is used solely as a power source. However the application of a reverse voltage (for example, via solar power) results in storage of energy associated with the BMFC. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/403796 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 22/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) Original (OR) Class H01M 2250/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234808 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Solid Energies Inc. (Anaheim, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Anaheim, California); Chunhu Tan (Anaheim, California); Tianyu Meng (Anaheim, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/617619 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234816 | KOSYAKOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATRION INC. (ALBANY, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALEXANDER KOSYAKOV (Champaign, Illinois); SOHEIL MALEKPOUR (Champaign, Illinois); DIPOBRATO SARBAPALLI (Brunswick, Ohio); DAH-SHYANG TSAI (Champaign, Illinois); CONNOR KNIAZ (Champaign, Illinois) |
| ABSTRACT | The disclosure relates to a functional interphase stabilizer for a battery having an organic nonaqueous solvent and a lithium salt in solution with the organic nonaqueous solvent. The disclosure also relates to a battery having an anode, a cathode, a separator, a functional interphase stabilizer having an organic nonaqueous solvent, and a lithium salt in solution with the organic nonaqueous solvent. The disclosure also relates to a method of making a functional interphase stabilizer including the steps of providing an organic nonaqueous solvent, adding a lithium salt to the organic nonaqueous solvent, and mixing the organic nonaqueous solvent and the lithium salt to form a solution. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492229 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2300/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235143 | Kaneda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TIPD, LLC (Tucson, Arizona); ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yushi Kaneda (Tucson, Arizona); Lloyd J. LaComb, JR. (Tucson, Arizona); Khanh Kieu (Tucson, Arizona) |
| ABSTRACT | Laser sources of the present invention allow for the efficient generation of harmonic frequencies from broadband sources. Over-compression and under-compression of a split signal result in two beams chirped in opposite directions. These two beams may be combined in a non-linear crystal to generate a narrow-band harmonic signal from a broadband source. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/150723 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/354 (20210101) G02F 1/3534 (20130101) G02F 1/3544 (20130101) G02F 1/3551 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) H01S 3/067 (20130101) H01S 3/0092 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235665 | Krishnamurthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sundar Krishnamurthy (Dublin, California); Conor O'Keeffe (Cork, Ireland); Deepak Dasalukunte (Beaverton, Oregon); Finbarr O'Regan (Innishannon, Cork, Ireland); Abhinav Vinod (San Jose, California) |
| ABSTRACT | An apparatus can include transceiver circuitry to receive an input signal from a target apparatus. The apparatus can further include a processing circuitry to determine position information of a source object and a target object. Based on the position information, the processing circuitry can calculate a relative velocity and determine a Doppler shift or carrier frequency offset in the input signal based on the relative velocity. The processing circuitry can adjust a local oscillator frequency based on a Doppler measured using the position information in an initial link acquisition phase. The processing circuitry can track the Doppler continuously over a range of tens of gigahertz accounting for Doppler phase ambiguities, and correct for a tracked Doppler shift by partially adjusting a local oscillator frequency and by correcting a residual Doppler shift digitally. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/972965 |
| CURRENT CPC | Transmission H04B 7/1855 (20130101) Original (OR) Class H04B 7/18513 (20130101) H04B 7/18521 (20130101) H04B 7/18543 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235687 | Adleman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | James R Adleman (San Diego, California); David Chao (San Diego, California) |
| ABSTRACT | An optical single sideband generation system comprising a RF signal generator generates a sawtooth drive voltage with a first frequency. A laser source provides the initial optical carrier with a second frequency that is modulated by a first phase modulator. The modulation shifts the optical carrier by the amount of the first frequency, and with added phase errors due to the imperfections of the sawtooth drive. A directional coupler allows the optical carrier to be divided into the error measurement path and the error correction path. The modulated signal goes to a phase detector that measures the phase error and converts the phase error signal to a baseband electrical signal. The optical signal at the output of the second phase modulator is the desired single sideband shifted from the original carrier with the phase errors of the signal generator suppressed by the error correction feedforward path. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/093895 |
| CURRENT CPC | Transmission H04B 10/503 (20130101) Original (OR) Class H04B 10/0795 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240236451 | Cappiello et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Gregory Cappiello (Windham, New Hampshire); George Turner (Westford, Massachusetts); Brian Edwards (Sterling, Massachusetts); Emma Landsiedel (Arlington, Massachusetts); Ryan Little (Worcester, Massachusetts) |
| ABSTRACT | According to some embodiments, a pressure tolerant camera system includes: an enclosure filled with an incompressible fluid and having a viewport through which light can pass; a digital image sensor provided within the enclosure; and a plurality of mirror lenses provided within the enclosure and arranged to reflect light from the viewport onto the digital image sensor. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405303 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) B63G 2008/004 (20130101) Optical Elements, Systems, or Apparatus G02B 7/182 (20130101) G02B 27/0012 (20130101) Pictorial Communication, e.g Television H04N 23/12 (20230101) H04N 23/51 (20230101) Original (OR) Class H04N 23/57 (20230101) H04N 23/64 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240236691 | BONATI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonardo BONATI (Boston, Massachusetts); Michele POLESE (Cambridge, Massachusetts); Salvatore D'ORO (Allston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | Provided herein are methods and systems for sharing spectrum, computing resources. and Radio Access Network (RAN) elements in a wireless communication network, the system including a centralized service management and orchestration (SMO) entity, the SMO including an optimization engine for determining one or more resource allocation policies responsive to one or more received tenant requests and based on network state information received from a radio access network (RAN) and deploying the determined resource allocation policies on the network, a plurality of edge datacenters configured to instantiate virtualized networking services in response to the deployed resource allocation policies from the optimization engine, and a plurality of cell sites, the cell sites operating the network in response to instructions from the edge datacenters consistent with the deployed resource allocation policies. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/230871 |
| CURRENT CPC | Wireless Communication Networks H04W 16/14 (20130101) Original (OR) Class H04W 24/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240236817 | Legaspi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Albert Kitagawa Legaspi (San Diego, California) |
| ABSTRACT | A target homing optimized routing protocol over an aerial service gateway relay domain. A method of proactive routing comprising the steps of designating each node of a plurality of nodes within a mobile ad-hoc network as either one of a plurality of target homeport nodes, one of a plurality of comms-relay nodes, or one of a plurality of sensor nodes, initializing a target homing optimized protocol by propagating a plurality of route chains to each of the plurality of comms-relay nodes and each of the plurality of sensor nodes, maintaining the plurality of route chains at each of the plurality of nodes, wherein a plurality of routing tables, each associated with one of the plurality of nodes, comprises the plurality of route chains, generating sensor information at the plurality of sensor nodes, and selectively transmitting the sensor information to the plurality target homeport nodes along a primary route chain. |
| FILED | Thursday, January 05, 2023 |
| APPL NO | 18/150644 |
| CURRENT CPC | Wireless Communication Networks H04W 40/30 (20130101) Original (OR) Class H04W 40/248 (20130101) H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237319 | Salour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Michael M. Salour (Carlsbad, California); De Yu Zang (Irvine, California); James G. Grote (Yellow Springs, Ohio) |
| ASSIGNEE(S) | Software Defined Technologies, Inc. (Carlsbad, California) |
| INVENTOR(S) | Michael M. Salour (Carlsbad, California); De Yu Zang (Irvine, California); James G. Grote (Yellow Springs, Ohio) |
| ABSTRACT | An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents and shielding guest material. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/369689 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/32 (20130101) C09D 199/00 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0209 (20130101) H05K 1/0216 (20130101) H05K 3/1283 (20130101) H05K 9/009 (20130101) H05K 9/0022 (20130101) H05K 9/0083 (20130101) Original (OR) Class H05K 2201/0257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237556 | Lei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Chan U Lei (Stamford, Connecticut); Suhas Ganjam (Fairfield, California); Lev Krayzman (New Haven, Connecticut); Robert J. Schoelkopf lll (Madison, Connecticut); Luigi Frunzio (North Haven, Connecticut) |
| ABSTRACT | Techniques are described to construct an electromagnetic resonator by arranging a resonant structure within a super-conducting cavity. The architecture of the design may provide a low loss superconducting cavity resonator that may exhibit multiple modes. The multimode nature of this resonator is produced in part by the resonant structure in such a way that allows the modes of the resonator to be adjusted through adjustment of the resonant structure rather than by having to alter the physical dimensions of the cavity, as would otherwise be required in a conventional superconducting cavity resonator. In some embodiments, the resonant structure may include a suspended superconductor comprising metal and/or metallized parts. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/277505 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) H10N 60/85 (20230201) H10N 60/805 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240226800 | Morajkar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mojave Energy Systems, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohan Morajkar (Sunnyvale, California) |
| ABSTRACT | A liquid/gas contactor unit includes a unit housing having a liquid inlet and a liquid outlet, and an air inlet and an air outlet. The liquid inlet and the liquid outlet are configured to flow liquid through the unit housing in a gravity liquid flow direction. The air inlet and the air outlet are configured to flow air through the unit housing in an air flow direction. A plurality of porous media layers are contained within the unit housing and along the air flow channel. Each porous media layer is separated from an adjacent porous media layer by an air gap. Each porous media layer has opposing major surfaces separated by a thickness. The opposing major surfaces are orthogonal to the gravity liquid flow direction. |
| FILED | Thursday, October 20, 2022 |
| APPL NO | 17/969864 |
| CURRENT CPC | Separation B01D 53/18 (20130101) Original (OR) Class B01D 53/1425 (20130101) B01D 53/1493 (20130101) B01D 2252/20 (20130101) B01D 2259/40083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226802 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuepeng Zhang (Naperville, Illinois); Jungkuk Lee (Bolingbrook, Illinois); Wei Chen (Naperville, Illinois); Shiyu Hu (Willowbrook, Illinois); Andrew Erwin (La Grange, Illinois); Feng Gao (Bolingbrook, Illinois) |
| ABSTRACT | A CO2 separation membrane can include a CO2-philic layer comprising one or more mobile CO2 carriers and one or more immobile CO2 carriers and a blended CO2-permeable and CO2-selective matrix that hosts the immobile or mobile CO2 carriers and porous nanostructures that adsorb water vapors. The CO2-philic layer can be disposed upstream of the CO2-permeance layer such that a flow of source gas to be separate enters the membrane from a feed side at which the CO2-philic layer is present and CO2 exits the membrane at a permeate side after passing through both the CO2-philic layer and the CO2-permeance layer. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410456 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 67/00791 (20220801) B01D 67/00793 (20220801) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 69/142 (20130101) B01D 69/147 (20130101) B01D 69/148 (20130101) B01D 69/1216 (20220801) B01D 69/14111 (20220801) B01D 71/68 (20130101) B01D 71/82 (20130101) B01D 71/381 (20220801) B01D 71/701 (20220801) B01D 2257/80 (20130101) B01D 2257/504 (20130101) B01D 2323/36 (20130101) B01D 2325/04 (20130101) B01D 2325/12 (20130101) B01D 2325/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226813 | REIMUND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ENERGY EXPLORATION TECHNOLOGIES, INC. (Austin, Texas); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | ENERGY EXPLORATION TECHNOLOGIES, INC. (Austin, Texas); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Kevin Kruschka REIMUND (Austin, Texas); Richelle LYNDON (Austin, Texas); Amit PATWARDHAN (Austin, Texas); Teague EGAN (Austin, Texas); Benny Dean FREEMAN (Austin, Texas) |
| ABSTRACT | Membrane materials and methods are disclosed for selectively separating or transporting ions in liquid media. In embodiments, the membranes comprise cellulose acetate polymer films having high cation, monovalent/divalent, and/or Li+/Mg2+ selectivity. Systems and methods for use of such membranes, including the direct extraction of lithium (DLE) from natural brines and other resources, also are disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546318 |
| CURRENT CPC | Separation B01D 61/44 (20130101) B01D 69/02 (20130101) Original (OR) Class B01D 71/16 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101) B01D 2325/32 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2301/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226818 | STRASSER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek J. STRASSER (Marlborough, Massachusetts); Hui XU (Acton, Massachusetts); Judith LATTIMER (Cambridge, Massachusetts) |
| ABSTRACT | Anion exchange membrane and methods of making and using the same. In one embodiment, the anion exchange membrane may be made by a method that includes a two-step polymerization. In the first step, an α-olefin monomer containing a pendant halide, such as 8-bromo-1-octene, may be polymerized by Ziegler-Natta polymerization to form a first polymer portion, the first polymer portion being a homopolymer. In the second step, the polymerization is charged with a non-functionalized α-olefin monomer, such as ethylene, thereby forming a second polymer portion, the second polymer being a copolymer made up predominantly of the non-functionalized olefin monomer. If desired, a small amount of an α-olefin monomer containing a crosslinking functionality may be included in the first and/or second steps. Following the two-step polymerization, the polymer is fabricated into a thin film. Thereafter, the thin film may be functionalized by replacing the pendant halides with pendant cations. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530437 |
| CURRENT CPC | Separation B01D 69/1251 (20220801) B01D 71/262 (20220801) Original (OR) Class B01D 2323/30 (20130101) B01D 2325/16 (20130101) B01D 2325/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226857 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haiying Chen (Oak Ridge, Tennessee); Josh A. Pihl (Oak Ridge, Tennessee); Todd J. Toops (Oak Ridge, Tennessee) |
| ABSTRACT | A layered-structure, multifunctional monolith catalyst is provided. The multifunctional monolith catalyst includes a monolithic substrate. A first layer is coated on a surface of the substrate. The first layer includes a first catalyst. A second layer is formed on top of the first layer. The second layer includes a second catalyst, and the second layer is porous. Layering of the first and second catalysts reduces degradation of one or both of the first and second catalysts, and increases a yield of the reaction catalyzed by the second catalyst. A method of converting carbon dioxide to dimethyl ether using the multifunctional monolith catalyst is also provided. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/371739 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/80 (20130101) Original (OR) Class B01J 29/65 (20130101) B01J 35/04 (20130101) B01J 35/0006 (20130101) B01J 35/10 (20130101) B01J 35/023 (20130101) Acyclic or Carbocyclic Compounds C07C 41/30 (20130101) C07C 2523/80 (20130101) C07C 2529/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226895 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Ying Zhu (Richland, Washington); Jongmin Woo (Richland, Washington); Ljiljana Pasa-Tolic (Richland, Washington) |
| ABSTRACT | A device for biological sample preparation and analysis is disclosed. The device includes a substrate and a plurality of spaced apart arrays disposed on an upper surface of the substrate. Each array includes a plurality of reaction vessels, each reaction vessel having a hydrophilic surface. A hydrophilic ring surrounds each array. Methods of making and using the device are also disclosed. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/546752 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502792 (20130101) B01L 2200/142 (20130101) B01L 2300/165 (20130101) B01L 2300/0819 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227006 | PILLAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi R. PILLAI (Knoxville, Tennessee); Soumya NAG (Farragut, Tennessee); Thomas FELDHAUSEN (Knoxville, Tennessee) |
| ABSTRACT | An alloy construction for separating a low oxygen content corrosive environment from a high oxygen content oxidizing environment includes a wall having a wall thickness and a first surface segment for contacting the low oxygen content corrosive environment, and a second surface segment for contacting the high oxygen content oxidizing environment. The alloy comprises, in weight percent: 0 to 5 Al; 5 to 30 Cr; 0 to 20 Co; 0 to 70 Fe; 0 to 2 Nb; 0 to 2 Ta; 0 to 3 Ti; 0 to 1 Si; 0 to 1 V; 0 to 2 Mn; 0 to 5 Cu; 0 to 30 Mo; 0 to 30 W; 0 to 0.1 P; 0 to 1 Zr; 0 to 1 Hf; 0 to 0.1 Y; 0.05 to 0.5 C; 0 to 0.1 N; and balance Ni. The alloy is compositionally graded from the first surface segment to the second surface segment. The wall composition has a stable FCC austenitic matrix microstructure, with strengthening phases comprising gamma prime with a volume fraction of 0 to 30% and carbides with a volume fraction of 0 to 5%. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405157 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 7/02 (20130101) Original (OR) Class B22F 10/28 (20210101) B22F 2998/10 (20130101) B22F 2999/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Alloys C22C 1/0433 (20130101) C22C 19/056 (20130101) C22C 19/057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227017 | Guillen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donna P. Guillen (Idaho Falls, Idaho); Robert V. Fox (Idaho Falls, Idaho); Dennis S. Tucker (Idaho Falls, Idaho); Troy B. Holland (New Albany, Indiana) |
| ABSTRACT | A method of forming an article comprises forming a feed material around one or more shapeholders and sintering the feed material and the one or more shapeholders to form a sintered article comprising the one or more shapeholders in a base material. The sintered article is exposed to a solvent to remove the one or more shapeholders from the base material. Additional methods are disclosed, as well as articles including one or more microchannels exhibiting a diameter of from about 5 μm to about 10 mm. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/486790 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/43 (20210101) B22F 10/62 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227086 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Zhang (Oak Ridge, Tennessee); Zhili Feng (Oak Ridge, Michigan); Dali Wang (Oak Ridge, Tennessee); Jian Chen (Oak Ridge, Tennessee); Hassan Ghassemi-Armaki (Warren, Michigan); Blair Carlson (Warren, Michigan) |
| ABSTRACT | Rapid and accurate quality prediction of resistance spot welding (RSW) for the automotive and other transportation sectors. A machine learning system and method incorporates materials information, e.g., material classification, surface coating, dimensions, stack-up conditions, etc., welding schedule, e.g., current, voltage, force, electrode displacement, welding equipment conditions, e.g., electrode information, water cooling, etc., as well as in-process measurable signals, e.g., heat generation, acoustic emission, etc., and offline weld attribute measurements to determine weld quality metrics. The system and method can also determine a set of resistance spot welding input parameters to produce a desired weld quality. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545435 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 11/11 (20130101) B23K 31/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227803 | Fuhs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karla Fuhs (Columbus, Indiana); Hoseinali Borhan (Bloomington, Indiana); Gayatri Adi (Columbus, Indiana); Bibin N. Pattel (Columbus, Indiana) |
| ABSTRACT | An electronic control system is configured to control a vehicle operating in a convoy by determining a vehicle motion reference parameter (VMRP) in response to a convoying control input (CCI), determining a braking capability of the vehicle including at least a regenerative braking capability, determining a minimum following distance between the vehicle and a forward vehicle of the convoy based at least in part upon the braking capability, and arbitrating among a plurality of control options including preforming a first modification of the VMRP determined to provide operation of the vehicle satisfying the minimum following distance and controlling motion of the vehicle using the first modification of the VMRP, performing a second modification of the VMRP determined to provide improved operating efficiency of the vehicle controlling motion of the vehicle using the second modification of the VMRP, and performing no modification of the VMRP and controlling motion of the vehicle using the VMRP without modification. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 18/049381 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/18 (20130101) B60W 20/14 (20160101) B60W 30/165 (20130101) Original (OR) Class B60W 30/18127 (20130101) B60W 2510/244 (20130101) B60W 2510/246 (20130101) B60W 2556/45 (20200201) Systems for Controlling or Regulating Non-electric Variables G05D 1/0293 (20130101) G05D 2201/0213 (20130101) Traffic Control Systems G08G 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227985 | ROBERTSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tyler ROBERTSON (North Attleboro, Massachusetts); Steven TRVALIK (Arlington, Massachusetts); Charles HANNON (Arlington, Massachusetts); David AUBREY (Pocasset, Massachusetts); Allan CHERTOK (Bedford, Massachusetts); Tyson LAWRENCE (Highlands Ranch, Colorado) |
| ABSTRACT | Disclosed herein are systems employing a power generating buoy separate from a host buoy but connected via tether, allowing the power generating buoy to be distant from the host buoy (e.g. an observational buoy) so as to minimize the impact of the power generating buoy on the host buoy. The tether is connected at one end to the power generating buoy and connectable to a floating host buoy, wherein the tether further comprises means for transferring power generated by the power-generating buoy to the host buoy; and wherein the tether is adapted to allow for independent movement of the power-generating buoy relative to the host buoy, and has no substantial hydrodynamic effect on or from the host buoy when connected. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469145 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/20 (20130101) Original (OR) Class Machines or Engines for Liquids F03B 13/1875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228278 | Sharma et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Anand Sharma (Albuquerque, New Mexico); Vitalie Stavila (Oakland, California); Sakun Duwal (Albuquerque, New Mexico); Dan Catalin Spataru (Danville, California) |
| ABSTRACT | Rare earth (RE) superhydrides exhibit high temperature superconductivity but are difficult to characterize and use in applications due to their high formation and stability pressures, which are typically in excess of 100 GPa. Cryomilling of metal precursors improves hydrogen reactivity and hydrogen uptake for forming such metal hydrides at lower pressures. As an example, an elemental lanthanum precursor was milled at liquid nitrogen temperatures for different time intervals. After exposure to gaseous hydrogen at 380° C. and 100 bar, a systematic enhancement of hydrogen absorption with increasing ball milling time was found for forming the LaHx, x=2-3 phase. Exposing the La precursor to pressures up to 60 GPa with an ammonia borane (BNH6) hydrogen source resulted in a hypervalent LaH4 phase. This LaH4 phase is associated with the suppression of a rhombohedral distortion of the Fm |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/403863 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 6/003 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228324 | Whittingham et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Whittingham (Vestal, New York); Fengxia Xin (Vestal, New York) |
| ABSTRACT | The present disclosure relates to compositions and methods for making lithium-transition metal oxide compounds suitable for use in lithium-ion cathodes for batteries. Further, the present disclosure relates to lithium-ion battery cathodes and an efficient method of preparing the materials and tuning electrochemical characteristics thereof. For example, the present disclosure relates to a process for making lithium-transition metal oxide compounds, including: forming a slurry by mixing a niobium compound including one or more of niobium ethoxide, niobium pentoxide, niobium dioxide, niobium monoxide, niobium chloride, niobium fluoride, ammonium niobium oxalate hydrate, or niobium oxalate, a lithium nickel manganese cobalt oxide cathode powder or a lithium nickel cobalt aluminum oxide cathode powder, and a solvent; and removing the solvent to form a modified lithium nickel manganese cobalt composition including niobium or a modified lithium nickel cobalt aluminum composition including niobium. In embodiments, the niobium compound is an oxide characterized as substantially lithium free, or a composition characterized as substantially lithium free. |
| FILED | Saturday, October 16, 2021 |
| APPL NO | 18/030868 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2004/84 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228339 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiang Wang (Idaho Falls, Idaho); Luis A. Diaz Aldana (Idaho Falls, Idaho); Daniel M. Ginosar (Idaho Falls, Idaho); Meng Shi (Idaho Falls, Idaho) |
| ABSTRACT | A method of removing impurities using an electrochemical membrane apparatus comprising introducing a leaching solution into an electrochemical membrane reactor. The leaching solution of the electrochemical apparatus comprises copper, aluminum, iron, cobalt, manganese, and nickel. The electrochemical membrane reactor comprises at least one positive electrode and at least one negative electrode, and the leaching solution is in contact with the at least one negative electrode. A current is applied through the electrochemical membrane reactor to adjust a pH of the leaching solution and copper is deposited on the at least one negative electrode. The aluminum and the iron are removed from the leaching solution, and the cobalt, the manganese, and the nickel are recovered from the leaching solution. An electrochemical membrane apparatus including an electrochemical membrane reactor is also disclosed. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 18/557030 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4676 (20130101) Original (OR) Class C02F 1/46109 (20130101) C02F 2001/46138 (20130101) C02F 2001/46161 (20130101) C02F 2101/203 (20130101) C02F 2103/16 (20130101) C02F 2103/34 (20130101) C02F 2201/46115 (20130101) C02F 2209/06 (20130101) C02F 2209/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228532 | Stebe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustee of the University of Pennsylvania (Philadelphia, Pennsylvania); The City College of New York (New York, New York); University of Illinois Chicago (Chicago, Illinois); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathleen J. Stebe (Penn Valley, Pennsylvania); Daeyeon Lee (Wynnewood, Pennsylvania); Ravi Radhakrishnan (Berwyn, Pennsylvania); César de la Fuente-Nunez (Philadelphia, Pennsylvania); Ivan Julian Dmochowski (Philadelphia, Pennsylvania); E. James Petersson (Wynnewood, Pennsylvania); Jason G. Marmorstein (Philadelphia, Pennsylvania); Stephen Crane (Clarksburg, New Jersey); Eshe Jael Hummingbird (Philadelphia, Pennsylvania); Yiming Wang (Philadelphia, Pennsylvania); Elizabeth J. Biddinger (Englewood, New Jersey); Charles Maldarelli (Wayne, New Jersey); Robert J. Messinger (New York, New York); Raymond S. Tu (Forest Hills, New York); Luis Ortuno Macias (Bayville, New York); Surabh S. KT (New York, New York); Mark L. Schlossman (Chicago, Illinois); Bikash Sapkota (Chicago, Illinois); Pan Sun (Oak Ridge, Tennessee); Monica Olvera de la Cruz (Wilmette, Illinois); Felipe Jiménez-Ángeles (Wilmette, Illinois); Baofu Qiao (Syossett, New York) |
| ABSTRACT | Provided is, inter alia, a method, comprising: complexing a peptide-comprising surfactant (PEPS) to a rare earth element (REE) cation in a solution so as to form a PEPS-REE complex, the PEPS comprising a REE-binding region that preferentially binds to one or more REEs; and optionally recovering the REE cation from an air-liquid interface. Also provided is a composition, comprising: a complex comprising (i) a peptide-comprising surfactant (PEPS), the PEPS comprising at least one lanthanide binding tag (LBT), the at least one LBT comprising one or more residues arranged in a binding region that coordinates with an REE cation so as to form a PEPS-REE cation complex, and (ii) an REE cation, the REE cation of the complex coordinated with the binding region of the PEPS. Further provided is a method, comprising application of at least one of molecular dynamics, artificial intelligence, and a genetic algorithm to design a PEPS that comprises an LBT and preferentially binds one REE over at least one other REE. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/448427 |
| CURRENT CPC | Peptides C07K 1/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229005 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min ZHANG (Lakewood, Colorado); Vladimir Vladimirovich LUNIN (Evergreen, Colorado); Hui WEI (Wheat Ridge, Colorado) |
| ABSTRACT | Disclosed herein are compositions and methods for making and using improved carbonic anhydrases for novel, sustainable, and low energy CO2 waste gas scrubbing technologies that are also transformational carbon capture technologies. Embodiments of methods, systems and compositions disclosed herein include, but are not limited to, non-aqueous solvents, advanced membranes, sorbents, and cryogenic systems that significantly reduce the cost of CO2 capture from coal and natural gas-fired power plants and industrial facilities. Methods disclosed herein reduce the energy and cost required for CO2 separation and can be applied for both pre-combustion and post-combustion CO2 capture. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 18/546920 |
| CURRENT CPC | Separation B01D 53/84 (20130101) B01D 2255/804 (20130101) B01D 2257/504 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class Enzymes C12Y 402/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229047 | Gonzalez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mojia Biotech Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramon Gonzalez (Tampa, Florida); James MacAllister Clomburg (Houston, Texas); Fayin Zhu (Tampa, Florida); Seung Hwan Lee (Tampa, Florida); Mohammadreza Nezamirad (Tampa, Florida) |
| ABSTRACT | This disclosure provides a new conceptual framework in which orthogonal, new-to-nature carbon and energy conversion pathways facilitate the synthesis of fuels and chemicals from carboxylic acid intermediates (CAis) driven by genetically altered microorganisms. This allows the CAi platform to generate diverse products at ≥100% carbon yield while retaining the established high product and energy efficiencies of fermentative metabolism. In another embodiment, a carboxylic acid platform for fuel and chemical production at high carbon and energy efficiency is also provided. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406738 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/16 (20130101) C12N 9/88 (20130101) C12N 9/0093 (20130101) C12N 9/93 (20130101) C12N 9/1029 (20130101) C12N 9/1217 (20130101) C12N 15/52 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/02 (20130101) C12P 1/04 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 102/01003 (20130101) C12Y 207/02006 (20130101) C12Y 301/0202 (20130101) C12Y 402/01028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229292 | Eom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Beom Eom (Madison, Wisconsin); Jungwoo Lee (Madison, Wisconsin); Jieun Kim (Madison, Wisconsin) |
| ABSTRACT | Apparatus and methods for growing films of complex layered metal oxides with high stoichiometries and high crystal qualities are provided. The layered complex metal oxides include two or more metals and oxygen and have a layered structure. The methods, which are referred to as hybrid pulsed laser deposition (hybrid PLD), synergistically combine the advantages of molecular beam epitaxy (MBE) and pulsed laser deposition (PLD) to grow complex metal oxide films that include metals with very different vapor pressures. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151550 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) Original (OR) Class C30B 29/24 (20130101) C30B 29/30 (20130101) C30B 29/32 (20130101) C30B 29/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229294 | STODDARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LEADING EDGE CRYSTAL TECHNOLOGIES, INC. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan STODDARD (Chalfont, Pennsylvania); Parthiv DAGGOLU (Danvers, Massachusetts); Alexander MARTINEZ (Woburn, Massachusetts); Peter KELLERMAN (Essex, Massachusetts) |
| ABSTRACT | An apparatus for forming a crystalline ribbon grown on a surface of a melt includes an inner chamber. A crucible in the inner chamber is configured to hold a melt. A cold initializer in the inner chamber faces an exposed surface of the melt. A process gas feed is in fluid communication with a process gas inlet of the inner chamber. An outer chamber surrounds at least part of the inner chamber and defines an opening for the process gas feed and a sump inlet. A sump gas feed is in fluid communication with the sump inlet. The sump gas feed is configured to deliver a sump gas to the sump region. The sump region also can include heaters and insulation. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 18/558998 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 27/02 (20130101) Original (OR) Class C30B 29/06 (20130101) C30B 29/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229648 | Barua et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ananda Barua (Schenectady, New York); Changjie Sun (Clifton Park, New York); Christopher Edward Wolfe (Niskayuna, New York); John Matthew Sassatelli (Valley Falls, New York) |
| ABSTRACT | A method of manufacturing an erosion-shielded turbine blade includes providing a turbine blade for use with a rotary machine. The turbine blade includes an airfoil extending between a root and a tip. The airfoil includes a pressure side and an opposite suction side, and each of the pressure and suction sides extends between a leading edge and a trailing edge. The method also includes printing a green body part by an additive manufacturing process by selectively depositing a binder solution across a particulate erosion-resistant material, and sintering the green body part to produce a post-sintering erosion shield that includes densified erosion-resistant material. The method also includes coupling the erosion shield to the leading edge of the turbine blade. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973198 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 6/007 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/005 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/10 (20130101) F05D 2230/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229653 | Karnati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sreekar Karnati (Guilderland, New York); Yang Jiao (Schenectady, New York); Changjie Sun (Clifton Park, New York); John Matthew Sassatelli (Valley Falls, New York); Anthony Poli (Niskayuna, New York) |
| ABSTRACT | A method of forming an erosion shield for a turbine blade includes depositing a layer of filler material defining an upper surface. The method also includes depositing a layer of erosion-resistant material across the upper surface of the layer of filler material. An interface is defined between the layer of filler material and the layer of erosion-resistant material and has a shape of the upper surface. The method also includes machining the layer of filler material to produce the erosion shield. The erosion shield has the layer of erosion-resistant material, the machined layer of filler material, and the interface defined therebetween. An inner surface of the erosion shield is defined by the machined layer of filler material that is sized and shaped for attaching to a leading edge of the turbine blade. Each of the interface and the inner surface extend a length of the erosion shield. |
| FILED | Tuesday, October 25, 2022 |
| APPL NO | 17/973085 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/286 (20130101) Original (OR) Class Wind Motors F03D 1/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230249 | Erno et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Jason Erno (Clifton Park, New York); Sathyanarayanan Raghavan (Ballston Lake, New York) |
| ABSTRACT | An additively manufactured heat exchanger assembly formed of a lattice structure with a plurality of shell structure unit cells. The plurality of shell structure unit cells each include at least one junction and a plurality of connectors coupled to the junction. The junction and the plurality of connectors form an integral surface. The heat exchanger assembly further includes a fluid boundary wall defined within the lattice structure to define an active heat exchanger portion. The active heat exchanger portion includes at least one working fluid contained within the fluid boundary wall. Further, at least one of the plurality of shell structure unit cells extends through and beyond the fluid boundary wall. Further, the shell structure unit cells may be isotropic. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 17/971022 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/0008 (20130101) F28D 2021/004 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230571 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanseup KIM (Salt Lake City, Utah); Seungbeom NOH (Salt Lake City, Utah); Shakir KHAN (Salt Lake City, Utah); Ling ZANG (Salt Lake City, Utah); Carlos H. MASTRANGELO (Salt Lake City, Utah) |
| ABSTRACT | A volatile compound source locating system can include an array of chemical sensors distributed in a detection volume. The individual chemical sensors can include a positive electrode, a negative electrode separated from the positive electrode by a switch gap, and a binding agent located at a plurality of binding sites in the switch gap. The binding agent can be selective for binding to a target volatile compound. The binding sites can be capable of binding molecules of the target compound to form an electrically conductive pathway between the positive and negative electrode when the chemical sensor is exposed to a threshold concentration of the target compound. A source locating module can be in electronic communication with the array of chemical sensors, and configured to estimate the location of the source of the target compound based on electronic signals from the array of chemical sensors. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/407655 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/122 (20130101) G01N 27/125 (20130101) Original (OR) Class G01N 33/0047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230983 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Peng Kevin Chen (Pittsburgh, Pennsylvania); Kehao Zhao (Pittsburgh, Pennsylvania); Mohan Wang (Pittsburgh, Pennsylvania); Sheng Huang (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of manufacturing an optical fiber sensing device includes steps of moving an optical fiber having a core linearly along a first direction, during the moving, directly writing a number of nanograting structures into the core using a laser beam generated by an ultrafast laser system, wherein the number of nanograting structures form a number of scattering points; and forming an energy transducing element on an outer surface of the optical fiber, wherein the number of scattering points is/are structured and configured to scatter light out of fiber core and into the transducing element to provide local power for the optical fiber sensing device. A system for performing the method is also provided. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/557335 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35312 (20130101) G01D 5/35316 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240231169 | Barile et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada (Reno, Nevada); Tynt Technologies, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada (Reno, Nevada); Tynt Technologies, Inc. (Boulder, Colorado) |
| INVENTOR(S) | Christopher J. Barile (Reno, Nevada); Nikhil C. Bhoumik (Reno, Nevada); Tyler Hernandez (Boulder, Colorado) |
| ABSTRACT | Disclosed herein are optoelectronically dynamic elements (e.g., windows, films, lenses, flat-panel displays, polymer-based electronics, thin film photovoltaics, glass doors, tools/devices used in X-ray diffraction and scanning electron microscopy analysis, among others) comprising non-aqueous zinc-based electrolytes that facilitate reversible zinc electrodeposition on the element. The disclosed non-aqueous zinc-based electrolytes are used in combination with a transparent working electrode and a counter electrode and facilitate depositing layers of zinc on the transparent working electrode so as to rapidly form an opaque zinc-containing coating on the working electrode upon application of a suitable voltage. The opaque zinc-containing coating can be rapidly stripped from the working electrode transitioning it back to a transparent state upon application of a suitable voltage. Also disclosed are methods of making and using the disclosed non-aqueous zinc-based electrolyte and elements described herein. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405478 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) Original (OR) Class G02F 1/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240231182 | Garcia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Colorado School of Mines (Golden, Colorado) |
| INVENTOR(S) | Sergio Carbajo Garcia (Los Angeles, California); Randy Lemons (Boulder Creek, California); Charles Durfee (Eldorado Springs, Colorado) |
| ABSTRACT | Systems and methods for shaping temporal and amplitude profiles of optical pulses in accordance with embodiments of the invention are illustrated. One embodiment includes at least two laser emitters where each emitter configured to generate at least two input optical pulses, a pulse-shaping device configured to apply dispersions of different orders on each of the at least two input pulses, and a nonlinear crystal where the at least two input pulses applied with dispersions combine to emit an output optical pulse having an angular frequency that is the sum of the angular frequencies of the at least two input pulses. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410944 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3534 (20130101) Original (OR) Class G02F 1/3551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232453 | Everhart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley Alexander Everhart (Overland Park, Kansas); Joseph Newkirk (Rolla, Missouri) |
| ABSTRACT | Methods of modeling metal alloys and forming those alloys are provided. The method involves comparing the strain accommodation and cleavage energies of a base alloy comprising a first metal and a chemical element different from the first metal. If a predetermined difference between those energies would be achieved, the base alloy will be sufficiently ductile. If that predetermined difference would not be achieved, the base alloy will not be sufficiently ductile, and the base alloy is modified (e.g., by adding a ductility component) until the predetermined difference in energies would be achieved, at which point, the alloy can be formed using conventional methods or further modified to achieve the desired degree of ductility. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492210 |
| CURRENT CPC | Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/74 (20130101) C21D 6/007 (20130101) Alloys C22C 1/03 (20130101) C22C 19/07 (20130101) C22C 33/06 (20130101) C22C 38/10 (20130101) C22C 38/12 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/02 (20130101) C22F 1/10 (20130101) Electric Digital Data Processing G06F 30/17 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233861 | Townshend et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Raphael Townshend (Stanford, California); Stephan Eismann (Stanford, California); Andrew Watkins (Stanford, California); Rhiju Das (Palo Alto, California); Ron O. Dror (Stanford, California) |
| ABSTRACT | Embodiments herein describe systems and methods to determine RNA structure and uses thereof. Many embodiments utilize one or more machine learning models to determine an RNA structure. In various embodiments, the machine learning model is trained using experimentally determined RNA structures. Certain embodiments identify one or more ligands or drugs that bind to an RNA structure, which can be used to treat an individual for a disease, disorder, or infection. Various embodiments determine structure of other molecules, including DNA, proteins, small molecules, etc. Further embodiments determine interactions between multiple molecules and/or molecule types (e.g., RNA-RNA interactions, RNA-DNA interactions, DNA-protein interactions, etc.) |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/562693 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/10 (20190201) G16B 15/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233972 | GARCIA-DIAZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRENDA L. GARCIA-DIAZ (AIKEN, South Carolina); CHRISTOPHER S. DANDENEAU (AUGUSTA, Georgia); DALE A. HITCHCOCK (AIKEN, South Carolina); DAVE BABINEAU (AIKEN, South Carolina); ROBERT SINDELAR (MARTINEZ, Georgia); HECTOR COLON-MERCADO (AIKEN, South Carolina); GEORGE K. LARSEN (AIKEN, South Carolina) |
| ABSTRACT | Disclosed are galvanic cells and methods for treating a molten salt by use of the galvanic cells. The galvanic cell can provide anti-corrosion treatment and improved corrosion resistance via electrochemical and chemical reactions involving a corrosive impurity in a molten salt. Reaction products of the chemical and electrochemical reactions include hydrogen gas that can carry hydrogen isotopes evolved in the molten salt. The system can also include removal of the hydrogen gas from the molten salt and separation and recovery of tritium contained therein. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969060 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 1/02 (20130101) G21G 2001/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234076 | Sovinec et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Courtney Leigh Hummell Sovinec (Albuquerque, New Mexico); Edward Steven Jimenez, Jr. (Albuquerque, New Mexico); Noelle Melissa Collins (Albuquerque, New Mexico); Gabriella Dalton (Albuquerque, New Mexico); Kyle R. Thompson (Albuquerque, New Mexico); Amber Lynn Dagel (Lafayette, Colorado) |
| ABSTRACT | A multi-metal patterned anode for an X-ray detector is provided. The anode comprises a substrate and at least one group of disjointed circular features formed on the substrate, wherein the circular features are made from different metals. The circular features in different groups have different radii, and the circular features in the same group have the same radii. The groups of circular features are radially arrayed on the substrate. The substrate is made of diamond or beryllium. |
| FILED | Wednesday, July 26, 2023 |
| APPL NO | 18/226510 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 35/14 (20130101) H01J 35/064 (20190501) H01J 35/112 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234344 | Trujillo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Joseph Trujillo (Overland Park, Kansas); Payman Zarkesh-Ha (Albuquerque, New Mexico) |
| ABSTRACT | Systems, methods, circuits, and devices for providing and using transistors in a physically unclonable function (PUF) circuit. The transistors comprise a split source drain configuration including one or more inflection segments that increase process variations between the transistors such that each transistor generates a unique output signal. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537236 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/576 (20130101) Original (OR) Class H01L 29/78 (20130101) H01L 29/0843 (20130101) Pulse Technique H03K 3/0315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234588 | Mandal |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Krishna C. Mandal (Columbia, South Carolina) |
| ABSTRACT | Described herein are methods of making, as well as self-biased UV photodetectors used to design self-powered UV sensors for harsh environment applications, e.g., advanced nuclear reactors and space missions, to provide wide bandgap semiconductors as high-efficiency self-biased UV photodetectors. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506413 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/872 (20130101) Original (OR) Class H01L 29/1608 (20130101) H01L 29/6606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234728 | Shin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | YoungHo Shin (LaGrange Highlands, Illinois) |
| ABSTRACT | The invention provides a cathode particle comprising a secondary particle comprised of primary particles sans lithium proximal to their surfaces, wherein each of the primary particles have embedded carbon layers or passageways. Also provided is a method for making a single crystal particle having embedded carbon layers, the method comprising dissolving metal salts and carbon stock in water to create a solution; mixing the solution with a lithium containing compound at a subcritical temperature of water to create a mixture of agglomerated particles; allowing the mixture to reach a hydrothermal reaction condition for a time to form carbon layered grain-free single crystal lithiated particles; removing surface lithium from the single crystal lithiated particles; drying the single crystal partially de-lithiated particles after washing and filtering; and heat-treating the particles after forming granulated secondary particles such that the secondary particles comprise a plurality of the primary particles physically contacting each other. |
| FILED | Tuesday, January 10, 2023 |
| APPL NO | 18/095408 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) H01M 4/0492 (20130101) H01M 4/587 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234834 | Alexander |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DayLyte, Inc. (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caleb Tyler Alexander (Knoxville, Tennessee) |
| ABSTRACT | Glassy carbon coatings exhibiting high thermal stability, high electrical and thermal conductivity, low friction, impermeability, and extreme resistance to chemical attack are disclosed. The glassy carbon coatings are formed from carbonization of a phenolic resin or non-graphitizable polymer. An optional thermal shock resistant substrate can be included. Methods of making and using the glassy carbon coatings are further disclosed. The glassy carbon coatings are particularly useful for inclusion in metal air batteries. |
| FILED | Saturday, January 06, 2024 |
| APPL NO | 18/406134 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/24 (20130101) H01M 4/0404 (20130101) H01M 4/663 (20130101) H01M 4/667 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 12/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235202 | Griffith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Channing Street Copper Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saul Thomas Griffith (San Francisco, California); Samuel Eli Calisch (Berkeley, California); Joshua Land (San Francisco, California); Tucker Gilman (Berkeley, California) |
| ABSTRACT | An intelligent energy system includes an energy-consuming appliance, a battery module coupled to the appliance, and a bidirectional converter coupled to the appliance and the battery module by a power bus. The battery module is configured to provide power to the appliance. The bidirectional converter converts between alternating current (AC) and direct current (DC) and interfaces with a power infrastructure external to the appliance. The system further includes a control unit communicatively coupled to the battery module, the bidirectional converter, and the appliance. The control unit is configured to determine a charge and discharge schedule for the battery module. The battery module coupled with the bidirectional converter provides uninterrupted power to the appliance, abstracts the power demands of the appliance from local power infrastructure, and allows for greater appliance peak power draw than would otherwise be practical or possible. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410913 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4207 (20130101) H01M 50/204 (20210101) H01M 50/251 (20210101) H01M 2220/10 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) Original (OR) Class H02J 3/381 (20130101) H02J 7/0013 (20130101) H02J 7/00032 (20200101) H02J 7/0063 (20130101) H02J 7/342 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235203 | Griffith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Channing Street Copper Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saul Thomas Griffith (San Francisco, California); Samuel Eli Calisch (Berkeley, California); Joshua Land (San Francisco, California); Tucker Gilman (Berkeley, California) |
| ABSTRACT | A stove appliance that includes a stove housing; one or more cooktops; a power cord with a plug configured to couple with an electrical power receptacle of a power distribution system; and a battery system comprising one or more batteries configured to: store power obtained from the power cord with the plug coupled with the electrical power receptacle of the power distribution system, and power the one or more cooktops. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526366 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4207 (20130101) H01M 50/204 (20210101) H01M 50/251 (20210101) H01M 2220/10 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) Original (OR) Class H02J 3/381 (20130101) H02J 7/0013 (20130101) H02J 7/00032 (20200101) H02J 7/0063 (20130101) H02J 7/342 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235452 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hang Dai (Niskayuna, New York); Kum Kang Huh (Niskayuna, New York); Rajib Datta (Niskayuna, New York); Cong Li (Niskayuna, New York); Vandana Prabhakar Rallabandi (Niskayuna, New York); Thomas Jahns (Madison, Wisconsin); Bulent Sarlioglu (Madison, Wisconsin) |
| ABSTRACT | A power converter is provided. In one aspect, the power converter has a first inverter and a second inverter electrically coupled with one another and with a power bus. First switches of the first inverter are arranged symmetrically with second switches of the second inverter so that, when switched in a pulse width modulated switching scheme, the first switches generate a first common mode signal and the second switches generate a second common mode signal that is one hundred eighty degrees out of phase with the first common mode signal. In another aspect, the power converter includes a buck stage having one or more pairs of symmetrically arranged buck switches that can be controlled to reduce or eliminate common mode electromagnetic interference in the buck stage. The power converter can also include one or more pairs of symmetrically arranged inductors. |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151010 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/00 (20190201) B60L 2200/10 (20130101) B60L 2210/40 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 2221/00 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/44 (20130101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 27/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235475 | Seigneur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Hubert Seigneur (Orlando, Florida); Ryan Smith (Austin, Texas) |
| ABSTRACT | Photoluminescence and electroluminescence are essential characterization techniques for photovoltaics cells and modules. For electroluminescence, the main technical challenge is easily injecting current into the photovoltaic to cause luminescence. The technique described herein enables daylight electroluminescence imaging without the need for external power sources. For photoluminescence, characterization is performed on photovoltaic cells, modules, strings, and arrays in daylight and without temporary mounting of LED modulators. Instead, the modulation is performed using a permanent electronic module installed within the electric circuit on the DC side. This enables automation or triggering of modulation on demand, 100% inspection without changes in hardware configuration because the cells are never shaded and provides a path to high throughput imaging. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504459 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 2207/10048 (20130101) G06T 2207/10144 (20130101) G06T 2207/20216 (20130101) G06T 2207/20224 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/15 (20141201) Original (OR) Class Pictorial Communication, e.g Television H04N 23/20 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237370 | Berry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | First Solar, Inc. (Tempe, Arizona); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | First Solar, Inc. (Tempe, Arizona); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Joseph Jonathan Berry (Boulder, Colorado); Le Chen (Fremont, California); Axel Finn Palmstrom (Golden, Colorado); Tze-Bin Song (Fremont, California); Vera Steinmann (Menlo Park, California); Natasha Teran (San Leandro, California); Aravamuthan Varadarajan (Fremont, California); Mengjin Yang (Lakewood, Colorado); Xueping Yi (San Jose, California); Zhibo Zhao (Novi, Michigan); Kai Zhu (Littleton, Colorado) |
| ABSTRACT | Methods and compositions for forming perovskite hole transport layers for use in manufacturing photovoltaic devices are described. Embodiments include using a plurality of hole transport materials to produce high-performance HTL contacts to improve performance and stability. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/277153 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/40 (20230201) H10K 30/86 (20230201) Original (OR) Class H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237371 | Berry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | First Solar, Inc. (Tempe, Arizona); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | First Solar, Inc. (Tempe, Arizona); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Joseph Jonathan Berry (Boulder, Colorado); Le Chen (Fremont, California); Axel Finn Palmstrom (Golden, Colorado); Tze-Bin Song (Fremont, California); Vera Steinmann (Menlo Park, California); Natasha Teran (San Leandro, California); Aravamuthan Varadarajan (Fremont, California); Xueping Yi (San Jose, California); Zhibo Zhao (Novi, Michigan); Kai Zhu (Littleton, Colorado) |
| ABSTRACT | Photovoltaic devices having contact layers are described herein. Devices, intermediate structures, and methods for making multilayer contacts for perovskite photovoltaic devices are provided. Embodiments include back contacts for N-I-P structures. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 18/277157 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/10 (20230201) H10K 30/50 (20230201) H10K 30/89 (20230201) Original (OR) Class H10K 71/60 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240225512 | YEO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woon-Hong YEO (Atlanta, Georgia) |
| ABSTRACT | An exemplary system and method are disclosed for a wearable soft bioelectronic system configured with strain isolators that can isolate its sensor electrode or other sensors in proximity or in contact with the skin from temporary stretching and relative motion of the skin due to gross body movements, e.g., walking. The exemplary system employs hard-soft materials and an isolation structure that facilitates the use of a wearable sensor that can be placed on the surface of the skin and minimize motion artifacts in the acquired signals during physical motion by the wearer. The exemplary system can employ stretchable sensors in combination with the strain isolators. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/563796 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/27 (20210101) A61B 5/28 (20210101) Original (OR) Class A61B 5/681 (20130101) A61B 2562/164 (20130101) A61B 2562/187 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225546 | COTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerard COTE (College Station, Texas); Justin MCMURRAY (College Station, Texas); Samuel IDAH-OZE (College Station, Texas) |
| ABSTRACT | A system includes a physiological measurement device, a pressure sensor, and a controller. The physiological measurement device includes a biosensor configured to measure physiological signals upon placement in contact with a user. The pressure sensor is configured to measure a surface contact pressure applied to the user by the biosensor. The controller is in communication with the pressure sensor or the biosensor (e.g. PPG or BioZ or other) or both. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/404959 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6831 (20130101) A61B 5/6843 (20130101) Original (OR) Class A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225561 | Weimer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Erich Weimer (Arlinton, Virginia); Steven Russell Messé (Wynnewood, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for detecting stroke by monitoring of upper limb movements. In some examples, a method for detecting stroke includes receiving, at a stroke detector implemented on at least one processor, movement data from an accelerometer attached to an upper limb of a patient for a period of time. The method includes analyzing, at the stroke detector, the movement data using a test statistic robust to motion distribution covariate shift to enable passive monitoring of the patient. The method includes outputting, at the stroke detector, an alarm signal in response to detecting a stroke using the movement data. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/563707 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/11 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/6824 (20130101) A61B 5/7207 (20130101) A61B 5/7282 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225764 | Behrens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael R. Behrens (Loudon, New Hampshire); Warren RUDER (West Mifflin, Pennsylvania) |
| ABSTRACT | A system for controlling a magnetic microdevice to move within a fluidic environment, comprising an imaging device, a multi-axis electromagnet for generating a magnetic field based on sinusoidal current signals, and a controller for controlling the multi-axis electromagnet based on a machine-learning model, and wherein for training the machine-learning model, the controller is configured to receive images of the fluidic environment and the magnetic microdevice from the imaging device, determine a state comprising position information of the magnetic microdevice based on the images, calculate a measure of performance associated with a first set of sinusoidal current signals previously inputted to the multi-axis electromagnet, wherein the calculated measure of performance is used to adjust parameters of the machine-learning model, and generate based on the position information and the first set of sinusoidal current signals using the machine-learning model, a second set of sinusoidal current signals as inputs for the multi-axis electromagnet. |
| FILED | Wednesday, March 20, 2024 |
| APPL NO | 18/610786 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/72 (20160201) A61B 34/73 (20160201) Original (OR) Class A61B 2034/731 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/038 (20130101) G01R 33/385 (20130101) Computer Systems Based on Specific Computational Models G06N 3/092 (20230101) Image Data Processing or Generation, in General G06T 7/70 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240225940 | Asbeck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Alan Thomas Asbeck (Cambridge, Massachusetts); Ye Ding (Cambridge, Massachusetts); Robert Joseph Dyer (Cambridge, Massachusetts); Ignacio Galiana Bujanda (Cambridge, Massachusetts); Arnar Freyr Larusson (Cambridge, Massachusetts); Brendan Thomas Quinlivan (Cambridge, Massachusetts); Kai Schmidt (Cambridge, Massachusetts); Diana Wagner (Cambridge, Massachusetts); Conor J. Walsh (Cambridge, Massachusetts); Michael Wehner (Cambridge, Massachusetts) |
| ABSTRACT | In at least one aspect, there is provided a system for generating force about one or more joints including a soft exosuit having a plurality of anchor elements and at least one connection element disposed between the plurality of anchor elements. The system also includes at least one sensor to determine a force the at least one connection element or at least one of the plurality of anchor elements and to output signals relating to the force, at least one actuator configured to change a tension in the soft exosuit and at least one controller configured to receive the signals output from the at least one sensor and actuate the at least one actuator responsive to the received signals. |
| FILED | Wednesday, August 03, 2022 |
| APPL NO | 17/880409 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/70 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/149 (20130101) A61H 2201/164 (20130101) A61H 2201/165 (20130101) A61H 2201/501 (20130101) A61H 2201/1215 (20130101) A61H 2201/1238 (20130101) A61H 2201/1246 (20130101) A61H 2201/1261 (20130101) A61H 2201/1481 (20130101) A61H 2201/1628 (20130101) A61H 2201/1652 (20130101) A61H 2201/1664 (20130101) A61H 2201/1671 (20130101) A61H 2201/5002 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5064 (20130101) A61H 2201/5069 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2201/5097 (20130101) A61H 2230/60 (20130101) A61H 2230/605 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226372 | Duvall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig L. Duvall (Nashville, Tennessee); Prarthana Patil (Nashville, Tennessee); Mukesh K Gupta (Nashville, Tennessee); Joshua Tyler McCune (Nashville, Tennessee); Richard d'Arcy (Nashville, Tennessee) |
| ABSTRACT | The presently-disclosed subject matter includes hydrophilic thioketal polymers and scaffolds formed therefrom. |
| FILED | Thursday, April 21, 2022 |
| APPL NO | 18/288034 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 27/60 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226389 | Mayes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board Of Regents, The University Of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Mayes (Austin, Texas); Christine E. Schmidt (Gainesville, Florida) |
| ABSTRACT | A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/195 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/16 (20130101) A61L 31/041 (20130101) Original (OR) Class A61L 31/145 (20130101) A61L 31/148 (20130101) A61L 2300/43 (20130101) A61L 2300/62 (20130101) A61L 2300/414 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226565 | Dayeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shadi A. Dayeh (San Diego, California); Youngbin Tchoe (San Diego, California); Andrew M. Bourhis (La Jolla, California) |
| ABSTRACT | A flexible electrode array with hundreds or thousands channels for clinical use includes an array of at least hundreds of electrodes on a flexible biocompatible polymer substrate. Perfusion through holes are provided through the substrate. Individual elongate leads connect to each of the electrodes, the elongate lead connections being supported by the flexible biocompatible polymer substrate and extending away from the array. Flexible biocompatible polymer insulates the individual elongate lead connections and supporting the array. An interposer with individual channel connections is conductively bonded to the individual elongate lead connections. Sterile bag packaging encloses a portion of the interposer, where the outer side of the package including the array and individual elongate lead is sterile while the inner side of the packaging is non-sterile. The portion interposer inside the package is configured to connect to a circuit board within the packaging. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 18/547999 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/36125 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/113 (20130101) H05K 1/181 (20130101) H05K 3/32 (20130101) H05K 2201/041 (20130101) H05K 2201/10325 (20130101) H05K 2201/10378 (20130101) H05K 2203/0384 (20130101) H05K 2203/1305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226950 | AMASSIAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina); North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Aram AMASSIAN (Raleigh, North Carolina); Nathaniel R. WOODWARD (Raleigh, North Carolina); Boyu GUO (Raleigh, North Carolina) |
| ABSTRACT | Spin coating systems and methods. In one aspect, a spin coater assembly is provided. The spin coater assembly includes a spinner configured for receiving a substrate thereon, a plurality of material dispensers, an arm assembly configured to selectively position one of the plurality of material dispensers over the substrate, and a controller in communication with each of the spinner, the plurality of material dispensers, and the arm assembly. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236256 |
| CURRENT CPC | Apparatus for Applying Fluent Materials to Surfaces, in General B05C 11/08 (20130101) Original (OR) Class Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240227997 | CURET |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar CURET (Boca Raton, Florida) |
| ABSTRACT | An apparatus and method for an unmanned underwater vehicle that utilizes at least one flexible robotic fin to provide a highly maneuverable vessel with station-keeping performance in tight spaces, close to ocean structures or missions where a low-speed or station-keeping vehicle is required. A propeller is also provided for providing the main propulsion during high-speed transition with assistance provided by the flexible robotic fin. The vehicle includes sonar and camera equipment as well as a plurality of other sensors for achieving navigation and communication functions while surveying the underwater marine environment. A system controller and motor controller are synchronized to provide deflection commands to ray elements in the flexible robotic fin to achieve particular maneuvers such as pitch, yaw, and roll in confined spaces. The commands are traveling waves that undulate the fin precisely and for station-keeping the commands are opposing wave commands that fix the vehicle at one position. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 18/278125 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 2008/004 (20130101) Marine Propulsion or Steering B63H 1/37 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228294 | Gopalan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Padma Gopalan (Madison, Wisconsin); Michael Scott Arnold (Middleton, Wisconsin); Stephanie Oliveras Santos (Madison, Wisconsin); Songying Li (Madison, Wisconsin) |
| ABSTRACT | Methods of sorting carbon nanotubes and methods of forming films of aligned carbon nanotubes using rod-coil copolymers are provided. The rod-coil copolymers have a tri-block or di-block architecture and include a conjugated polymer segment (“rod” segment) that binds the copolymer to the carbon nanotubes via pi-pi interactions and a non-conjugated polymer segment (“coil” segment) that aids with the sorting and dispersion of the carbon nanotubes in solution and/or controls the spacing of the carbon nanotubes in films made therefrom. |
| FILED | Wednesday, January 11, 2023 |
| APPL NO | 18/152900 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/159 (20170801) C01B 32/172 (20170801) Original (OR) Class C01B 32/174 (20170801) C01B 2202/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Compositions of Macromolecular Compounds C08L 47/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228335 | WALKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roxanne WALKER (Ann Arbor, Michigan); Joseph Groele (Ann Arbor, Michigan); Terese Olson (Ann Arbor, Michigan); John E. Foster (Ann Arbor, Michigan) |
| ABSTRACT | A system and method for processing a fluid to be treated. The flow reactor system having a detention tank having an influent and an effluent. The detention tank receiving the fluid to be treated from the influent and outputting a treated fluid from the effluent. The flow reactor system having a recirculation system fluidly coupled to the detention tank and configured to circulate a recirculation fluid from the detention tank to the detention tank. The recirculation system having a first line fluidly coupled to the detention tank, a second line downstream of the first line fluidly coupled to the detention tank, a recirculation pump fluidly coupled between the first line and the second line and providing a fluid driving force, and a plasma reactor operably coupled to the second line to treat the recirculation fluid to achieve a contact time sufficient to process the fluid to be treated and output the treated fluid. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404551 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4608 (20130101) Original (OR) Class C02F 2201/002 (20130101) C02F 2201/4614 (20130101) C02F 2209/40 (20130101) C02F 2209/44 (20130101) C02F 2301/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228424 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yagya Gupta (Newark, Delaware); Laura E. Beckett (Ingolstadt, Delaware); Sunitha Sadula (Wilmington, Delaware); Dionisios G. Vlachos (Newark, Delaware); LaShanda T. Korley (Middletown, Delaware) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Yagya Gupta (Newark, Delaware); Laura E. Beckett (Ingolstadt, Delaware); Sunitha Sadula (Wilmington, Delaware); Dionisios G. Vlachos (Newark, Delaware); LaShanda T. Korley (Middletown, Delaware) |
| ABSTRACT | Disclosed herein is a process for separating phenolic acids, comprising a step a) of contacting a feed containing at least two different phenolic acids (PA) with an extraction solvent to extract the at least two different PAs in a first PA containing liquid. The process also comprises a step b) of contacting the first PA containing liquid with a solid molecular imprinted polymer (MIP), such that the MIP captures a target PA from the at least two different PAs, to thereby form a first PA bound MIP dispersed in a second PA containing liquid, where the second PA containing liquid comprises at least one PA and none or a substantially lesser amount of the target PA originally present in the first PA containing liquid. The process further comprises a step c) of separating the first phenolic acid bound MIP from the second PA containing liquid, and a step d) of separating the target phenolic acid from the first PA bound MIP to obtain a recovered MIP, wherein the recovered MIP is substantially free of the target phenolic acid. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490069 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/58 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/08 (20130101) C08J 2333/26 (20130101) C08J 2339/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228524 | MORROW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York); Ferric Contrast Inc. (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Eric M. SNYDER (Tonawanda, New York); Patrick BURNS (Germantown, New York); Elizabeth A. KRAS (Amherst, New York); Jaclyn RAYMOND (Buffalo, New York) |
| ABSTRACT | The present application describes novel Fe(III) macrocyclic complexes that have hydroxy pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure: (I) or (II) where high spin Fe(III) is chelated thereto. The present application also describes novel Fe(III) macrocyclic complexes that have hydroxypropyl pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 18/551458 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) A61K 49/143 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228724 | Zheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi Zheng (Canton, Massachusetts); Yanpei Tian (Boston, Massachusetts); Xiaojie Liu (Boston, Massachusetts) |
| ABSTRACT | Melamine Formaldehyde (MF) photonic cooling bulk is disclosed for covering outer surfaces of a building. The MF photonic cooling bulk comprises a mass of hydraulically pressed MF microparticles that has been thermally annealed to form a fire and corrosion-resistant, cross-linked photonic cooling bulk configured to reflect incident solar irradiation and radiate heat from the building to the outer space. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 18/276721 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/24 (20130101) Original (OR) Class C08J 2205/044 (20130101) C08J 2207/00 (20130101) C08J 2361/28 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) C09K 21/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228783 | Fini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elham Fini (Phoenix, Arizona); Farideh Pahlavan (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elham Fini (Phoenix, Arizona); Farideh Pahlavan (Tempe, Arizona) |
| ABSTRACT | A bio-modified asphalt binder includes an asphalt binder and a phenol-rich oil. The phenol-rich oil can be a bio-oil. Examples of suitable sources for the bio-oil include pine bark, walnut shells, peanut shells, coconut husks, birch, and fir. The bio-modified asphalt binder increases durability and decreases long term oxidative damage compared with unmodified asphalt binder. A bio-modified asphalt includes the bio-modified asphalt binder and aggregate material and can be used in building materials such as pavement, roads, and roofing materials. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410633 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/13 (20130101) Compositions of Macromolecular Compounds C08L 95/00 (20130101) Original (OR) Class C08L 2555/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228981 | Wimmer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eckard Wimmer (East Setauket, New York); Steve Skiena (Setauket, New York); Steffen Mueller (Kings Point, New York); Bruce Futcher (Setauket, New York); Dimitris Papamichail (Newtown, Pennsylvania); John Robert Coleman (Blauvelt, New York); Jeronimo Cello (Port Jefferson, New York) |
| ABSTRACT | This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/13 (20130101) A61K 39/145 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2720/12361 (20130101) C12N 2740/15061 (20130101) C12N 2760/16061 (20130101) C12N 2760/16121 (20130101) C12N 2760/16134 (20130101) C12N 2760/16162 (20130101) C12N 2770/20061 (20130101) C12N 2770/24161 (20130101) C12N 2770/32061 (20130101) C12N 2770/32621 (20130101) C12N 2770/32634 (20130101) C12N 2770/32661 (20130101) C12N 2770/32662 (20130101) C12N 2770/32671 (20130101) C12N 2770/32721 (20130101) C12N 2770/32761 (20130101) C12N 2770/32762 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229020 | Agarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nayan Agarwal (Cambridge, Massachusetts); Ashwin Gopinath (Cambridge, Massachusetts); Emily Wu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are inorganic nucleic acid supramolecular structures and methods for making them. In certain aspects, the construct includes a structured nucleic acid polymer micelle, which micelle includes a structured nucleic acid template; one or more functional moieties attached to the template; and polymers that interact with nucleic acid present in the template to form the structured nucleic acid polymer micelle; and an inorganic shell surrounding the structured nucleic acid template, in which the one or more functional moieties extend outside the structured nucleic acid polymer micelle and the inorganic shell to maintain functionality. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/343768 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00722 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229021 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey J. Wilson (Atlanta, Georgia) |
| ABSTRACT | The present disclosure provides nucleic acid constructs and cell compositions for transcriptionally modifying a bacterial population within the gastrointestinal tract of a subject, and methods of use thereof. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/490880 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229051 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri); Donald Danforth Plant Science Center (DDPSC) (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing Yang (Columbia, Missouri); Sinian Char (Columbia, Missouri); Riqing LI (Columbia, Missouri) |
| ABSTRACT | The present disclosure is generally directed to gene editing in plant chloroplast and plant mitochondrial double-stranded DNA. Disclosed herein are cytosine base editors tailored for chloroplast and mitochondrial genomes in plants using plant-specific chloroplast and mitochondrial targeting peptides, a TALE, and a DNA deaminase. The systems of the present disclosure include DNA vectors and protocols to use them for gene editing in plants. |
| FILED | Thursday, February 17, 2022 |
| APPL NO | 18/546837 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) C07K 2319/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/8213 (20130101) C12N 15/8214 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229293 | Ahmad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Iftikhar Ahmad (Irmo, South Carolina); Mohi Uddin Jewel (West Columbia, South Carolina); Samiul Hasan (Columbia, South Carolina) |
| ABSTRACT | Described herein are alternative uses of silicon for β-Ga2O3 MOCVD heteroepitaxy as a phase stabilizer in the form of silicon-oxygen (Si—O) bonding that provides thermal annealing for achieving smooth and thick monoclinic phase-pure gallium oxide (β-Ga2O3) on sapphire, which can provide β-Ga2O3 growth on thermally conductive hexagonal substrates, such as AlN, 4H—SiC, and 6H—SiC. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506315 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/183 (20130101) Original (OR) Class C30B 29/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0262 (20130101) H01L 21/02458 (20130101) H01L 21/02565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230335 | Roumeliotis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Stergios I. Roumeliotis (St. Paul, Minnesota); Kejian J. Wu (Minneapolis, Minnesota); Chao Guo (Minneapolis, Minnesota) |
| ABSTRACT | A vision-aided inertial navigation system (VINS) comprises an image source for producing image data along a trajectory. The VINS further comprises an inertial measurement unit (IMU) configured to produce IMU data indicative of motion of the VINS and an odometry unit configured to produce odometry data. The VINS further comprises a processor configured to compute, based on the image data, the IMU data, and the odometry data, state estimates for a position and orientation of the VINS for poses of the VINS along the trajectory. The processor maintains a state vector having states for a position and orientation of the VINS and positions within the environment for observed features for a sliding window of poses. The processor applies a sliding window filter to compute, based on the odometry data, constraints between the poses within the sliding window and compute, based on the constraints, the state estimates. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/443035 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/28 (20130101) G01C 21/1656 (20200801) Original (OR) Class Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 7/246 (20170101) G06T 7/277 (20170101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230634 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leidong Mao (Watkinsville, Georgia); Yang Liu (Athens, Georgia) |
| ABSTRACT | The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/382849 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2200/0647 (20130101) B01L 2400/043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1484 (20130101) G01N 33/54366 (20130101) Original (OR) Class G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230831 | DHEKNE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashutosh DHEKNE (Marietta, Georgia); Yifeng CAO (Atlanta, Georgia); Mostafa H. AMMAR (Atlanta, Georgia) |
| ABSTRACT | An exemplary system and method are disclosed for a handheld or hand-enclosed instrument configured with ultra-wideband localization using unidirectional messaging protocol based on time difference of arrival (TDoA) measurements that can be used as inputs, in a realtime control loop, to a software application that uses the handheld or hand-enclosed instrument as an input user interface. The handheld or hand-enclosed instrument can be readily employed for UI in large work areas (e.g., 2D), such as a whiteboard or wallboard, with sub-millimeter resolution and sub-millisecond latency. The handheld or hand-enclosed instrument can be readily employed in a UI device for non-conforming 3D workspace such as a sculpting instrument, in hand-enclosed game interface, as a remote medical instrument, among others described herein. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 18/558861 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/06 (20130101) Original (OR) Class G01S 5/021 (20130101) G01S 5/0247 (20130101) G01S 5/0264 (20200501) G01S 5/02216 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230881 | ADIB et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Fadel ADIB (Cambridge, Massachusetts); Laura Noelle DODDS (Cambridge, Massachusetts); Aline EID (Ann Arbor, Michigan); Isaac S. PERPER (Medford, Massachusetts) |
| ABSTRACT | A handheld system radio frequency identification (RFID) system for fine-grained RFID localization of an RFID target. Also disclosed is a mechanism for localizing RFID targets at all orientations through software-controlled polarization of two LP antennas. The system may detect an RFID target using a generated circularly polarized (CP) RF signal and accurately localize the RFID target using a generated linearly polarized (LP) signal. The disclosed systems and techniques discover and localize RFID concurrently and regardless of RFID target orientation. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505355 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/75 (20130101) Original (OR) Class G01S 13/867 (20130101) Antennas, i.e Radio Aerials H01Q 21/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240231118 | HAZINEH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Dean Samer HAZINEH (Cambridge, Massachusetts); Zhujun SHI (Cambridge, Massachusetts); Qi GUO (Cambridge, Massachusetts); Todd ZICKLER (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed is a sensor for determining a physical characteristic, comprising a linear polarizer, a polarization-sensitive metalens, positioned between the linear polarizer and a photosensor, configured to manipulate light from a scene filtered by the linear polarizer, according to two or more phase profiles to simultaneously produce at least two spatial frequency filtered images on a surface of the photosensor, and processing circuitry configured to receive, from the photosensor, a measurement corresponding to the at least two spatial frequency filtered images, and determine, according to the measurement, a depth associated with at least one feature in the scene. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 18/559038 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/24 (20130101) Optical Elements, Systems, or Apparatus G02B 3/08 (20130101) G02B 27/286 (20130101) Original (OR) Class G02B 27/288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232292 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi Xu (Endwell, New York); Zhongfei Mark Zhang (Vestal, New York) |
| ABSTRACT | The general problem of pattern change discovery between high-dimensional data sets is addressed by considering the notion of the principal angles between the subspaces is introduced to measure the subspace difference between two high-dimensional data sets. Current methods either mainly focus on magnitude change detection of low-dimensional data sets or are under supervised frameworks. Principal angles bear a property to isolate subspace change from the magnitude change. To address the challenge of directly computing the principal angles, matrix factorization is used to serve as a statistical framework and develop the principle of the dominant subspace mapping to transfer the principal angle based detection to a matrix factorization problem. Matrix factorization can be naturally embedded into the likelihood ratio test based on the linear models. The method may be unsupervised and addresses the statistical significance of the pattern changes between high-dimensional data sets. |
| FILED | Wednesday, February 14, 2024 |
| APPL NO | 18/441887 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Original (OR) Class G06F 18/213 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232488 | Emmert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University Of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | John Martin Emmert (Dayton, Ohio); Anvesh Perumalla (Dayton, Ohio); Heiko Stowasser (Cincinnati, Ohio) |
| ABSTRACT | An apparatus may include a processor configured to synthesize a first configuration file associated with a target field-programmable gate array (FPGA), and a second configuration file associated with the target FPGA, wherein first look-up-table (LUT) bits of the first configuration file are the logical inverse of second LUT bits of the second configuration file, and first non-LUT bits of the first configuration file are the same as second non-LUT bits of the second configuration file, and generate a LUT mask indicating which bits of the first configuration file and the second configuration file correspond to the first LUT bits and the second LUT bits by performing a bit-wise exclusive OR operation between the first configuration file and the second configuration file. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494300 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/331 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232718 | Seo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jae-sun Seo (Tempe, Arizona); Jian Meng (Tempe, Arizona); Li Yang (Tempe, Arizona); Deliang Fan (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Jae-sun Seo (Tempe, Arizona); Jian Meng (Tempe, Arizona); Li Yang (Tempe, Arizona); Deliang Fan (Tempe, Arizona) |
| ABSTRACT | A method of training a machine learning algorithm comprises providing a set of input data, performing transforms on the input data to generate augmented data, to provide transformed base paths into machine learning algorithm encoders, segmenting the augmented data, calculating main base path outputs by applying a weighting to the segmented augmented data, calculating pruning masks from the input and augmented data to apply to the base paths of the machine learning algorithm encoders, the pruning masks having a binary value for each segment in the segmented augmented data, calculating sparse conditional path outputs by performing a computation on the segments of the segmented augmented data, and calculating a final output as a sum of the main base path outputs and the sparse conditional path outputs. A computer-implemented system for learning sparse features of a dataset is also disclosed. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494330 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233563 | Ramani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Jingyu Shi (West Lafayette, Indiana); Rahul Jain (West Lafayette, Indiana) |
| ABSTRACT | A learning system is disclosed that leverages intention-driven causality to enhance skill learning. The learning system enables an author to easily develop mixed reality (MR) tutorial content for performing a task that advantageously captures causal relationships between steps and, thus, enables such causality to be conveyed to the novice user when learning how to perform the task. To this end, the learning system leverages a novel hierarchical representation of causality and intention alongside a systematic workflow suitable for designing skill learning content. By preserving and presenting causal information to the novice user, the user can better understand not only the steps required to perform a task, but also why each step is performed. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492156 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) G06T 2200/24 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) Original (OR) Class G09B 19/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233876 | Leburton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Jean-Pierre Leburton (Urbana, Illinois); Olgica Milenkovic (Urbana, Illinois); Rajat Chakraborty (Urbana, Illinois) |
| ABSTRACT | Systems and methods are provided for encoding information as the pattern of the lengths of RNA tails (or other tail biomolecules, e.g., polypeptides) attached to a dsDNA (or other backbone biomolecule) and the relative locations of attachment thereto. This information can be quickly and accurately read out by passing such information-encoding payload biomolecules through a nanopore and detecting the pattern of conductance of the pore (e.g., the ionic conductance through the pore and/or the transverse conductance of the membrane bearing the pore) as the payload passes therethrough. The conductance can be processed by subtracting a time-varying correction factor therefrom that represents the expected conductance for a ‘tail-free’ backbone as it transits through the pore, by applying a time-varying velocity factor that is dependent on the number of tails present in the pore over time to normalize individual tail dwell times, and/or other processing steps. |
| FILED | Tuesday, January 02, 2024 |
| APPL NO | 18/402438 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 50/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235148 | Loughlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hudson Alexander Loughlin (Boston, Massachusetts); Vivishek Sudhir (Cambridge, Massachusetts) |
| ABSTRACT | A feedback oscillator, with an amplifier whose output is partially fed back to its input, provides a stable reference for standardization and synchronization. The laser is a feedback oscillator whose performance can be limited by quantum fluctuations. The resulting frequency instability, quantified by the Schawlow-Townes formula, sets a limit to laser linewidth. Here, we show that the Schawlow-Townes formula applies to feedback oscillators beyond lasers. This is because it arises from quantum noise added by the amplifier and an out-coupler in the feedback loop. Tracing the origin of quantum noise in an oscillator informs techniques to systematically evade it: squeezing and entanglement can enable sub-Schawlow-Townes linewidth feedback oscillators. We clarify the quantum limits to the stability of feedback oscillators, derive a standard quantum limit (SQL) for feedback oscillators, and disclose quantum strategies for realizing sub-SQL feedback oscillators. |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/398383 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1112 (20130101) H01S 3/1304 (20130101) H01S 3/1305 (20130101) Original (OR) Class H01S 3/1307 (20130101) H01S 3/1683 (20130101) H01S 3/094026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235206 | Preindl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Preindl (New York, New York); Liwei Zhou (New York, New York); William-Michael Eull (Oakville, Ontario, Canada); Matthew Jahnes (New York, New York) |
| ABSTRACT | Disclosed are implementations that include a power converter system and method including an N-phase power converter stage having to an alternating current (AC) side and a direct current (DC) side, with N≥1. The system and method further include an N-phase LC filter comprising one or more capacitors, wherein respective one or more neutral points of the one or more capacitors are electrically connected to a DC negative terminal of a DC source. A control system drives power switching elements of the N-phase power converter stage to convert received power and to output converted power. The control system drives the power switching elements using variable frequency soft switching at a frequency of at least 20 kHz. The power converter may have bidirectional operation to operate in a traction mode to drive a motor or a charging mode to charge a DC source. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 18/292318 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/322 (20200101) Original (OR) Class H02J 7/02 (20130101) H02J 2203/20 (20200101) H02J 2207/20 (20200101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 27/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240235580 — WAVEFORM-TRIGGERED RECEPTION AND BUFFERING FOR MILLIMETER-WAVE SOFTWARE-DEFINED RADIOS
| US 20240235580 | SAHIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALPHAN SAHIN (COLUMBIA, South Carolina) |
| ABSTRACT | The disclosure deals with methodology and system subject matter for a low-cost and portable millimeter-wave software-defined radio (SDR) which supports wireless experimentation in the 60 GHz band. The SDR uses a homodyne transceiver and provides a Transmission Control Protocol/Internet Protocol (TCP/IP)-based interface for companion computer (CC)-based baseband signal processing. To address the large difference between the processing speed of the CC and the sample rate of analog-to-digital converters, we use a disclosed method, called waveform-triggered reception (WTR), where a hard-coded block detects a special trigger waveform to acquire a predetermined number of in-phase/quadrature (IQ) data samples upon the detection. A buffer mechanism is used to support discontinuous transmissions. Using both the WTR and discontinuous transmissions, we can conduct a beam sweeping experiment, to evaluate 4096 beam pairs rapidly without compromising the flexibility of the CC-based processing. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495285 |
| CURRENT CPC | Transmission H04B 1/30 (20130101) H04B 1/0032 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240236691 | BONATI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonardo BONATI (Boston, Massachusetts); Michele POLESE (Cambridge, Massachusetts); Salvatore D'ORO (Allston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | Provided herein are methods and systems for sharing spectrum, computing resources. and Radio Access Network (RAN) elements in a wireless communication network, the system including a centralized service management and orchestration (SMO) entity, the SMO including an optimization engine for determining one or more resource allocation policies responsive to one or more received tenant requests and based on network state information received from a radio access network (RAN) and deploying the determined resource allocation policies on the network, a plurality of edge datacenters configured to instantiate virtualized networking services in response to the deployed resource allocation policies from the optimization engine, and a plurality of cell sites, the cell sites operating the network in response to instructions from the edge datacenters consistent with the deployed resource allocation policies. |
| FILED | Monday, August 07, 2023 |
| APPL NO | 18/230871 |
| CURRENT CPC | Wireless Communication Networks H04W 16/14 (20130101) Original (OR) Class H04W 24/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237206 | STRAND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot J. STRAND (Boulder, Colorado); Eloise BIHAR (Boulder, Colorado); Gregory L. WHITING (Boulder, Colorado) |
| ABSTRACT | A printed electric circuit comprises a printed planar substrate. The printed planar surface comprises one or more traces integrated into the printed planar structure. The one or more traces comprise a hydrophilic additive to create ion reservoirs within an organic semiconductor layer. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 18/571984 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/52 (20130101) C09D 11/102 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0098 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) Original (OR) Class H05K 1/111 (20130101) H05K 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240226129 | Grindrod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Shuttle Pharmaceuticals, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Grindrod (Rockville, Maryland); Mira Jung (Rockville, Maryland); Olga Timofeeva (Rockville, Maryland); Milton Brown (Rockville, Maryland); Anatoly Dritschilo (Rockville, Maryland) |
| ABSTRACT | Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 2121/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226818 | STRASSER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek J. STRASSER (Marlborough, Massachusetts); Hui XU (Acton, Massachusetts); Judith LATTIMER (Cambridge, Massachusetts) |
| ABSTRACT | Anion exchange membrane and methods of making and using the same. In one embodiment, the anion exchange membrane may be made by a method that includes a two-step polymerization. In the first step, an α-olefin monomer containing a pendant halide, such as 8-bromo-1-octene, may be polymerized by Ziegler-Natta polymerization to form a first polymer portion, the first polymer portion being a homopolymer. In the second step, the polymerization is charged with a non-functionalized α-olefin monomer, such as ethylene, thereby forming a second polymer portion, the second polymer being a copolymer made up predominantly of the non-functionalized olefin monomer. If desired, a small amount of an α-olefin monomer containing a crosslinking functionality may be included in the first and/or second steps. Following the two-step polymerization, the polymer is fabricated into a thin film. Thereafter, the thin film may be functionalized by replacing the pendant halides with pendant cations. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530437 |
| CURRENT CPC | Separation B01D 69/1251 (20220801) B01D 71/262 (20220801) Original (OR) Class B01D 2323/30 (20130101) B01D 2325/16 (20130101) B01D 2325/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228524 | MORROW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York); Ferric Contrast Inc. (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Eric M. SNYDER (Tonawanda, New York); Patrick BURNS (Germantown, New York); Elizabeth A. KRAS (Amherst, New York); Jaclyn RAYMOND (Buffalo, New York) |
| ABSTRACT | The present application describes novel Fe(III) macrocyclic complexes that have hydroxy pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure: (I) or (II) where high spin Fe(III) is chelated thereto. The present application also describes novel Fe(III) macrocyclic complexes that have hydroxypropyl pendants with a third anionic ancillary group for improved MR imaging in vivo. The complexes have the following general structure. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 18/551458 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) A61K 49/143 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230002 | Hess et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Enduralock, LLC (Lenexa, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold Hess (Leawood, Kansas); Deeptesh Selvaraj (Pitt Meadows, Canada); Kishan Srinivas Indrani (Lenexa, Kansas); Zoltan Szekely (Cypress, Texas); Caleb Grabill (Olathe, Kansas); Jonathan Poulter (Denver, Colorado) |
| ABSTRACT | A docking system for use with in-space structures includes a first connector attached to a first in-space structure and a second connector attached to a second in-space structure. The first connector includes a first housing that defines a recess. The second connector includes a second housing that is received within the recess of the first housing. The docking system also includes an engagement mechanism configured to secure the second housing in the recess. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409280 |
| CURRENT CPC | Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 37/35 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/71 (20130101) H01R 13/533 (20130101) H01R 13/631 (20130101) H01R 13/635 (20130101) H01R 13/6683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234808 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Solid Energies Inc. (Anaheim, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Anaheim, California); Chunhu Tan (Anaheim, California); Tianyu Meng (Anaheim, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/617619 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240234834 | Alexander |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DayLyte, Inc. (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caleb Tyler Alexander (Knoxville, Tennessee) |
| ABSTRACT | Glassy carbon coatings exhibiting high thermal stability, high electrical and thermal conductivity, low friction, impermeability, and extreme resistance to chemical attack are disclosed. The glassy carbon coatings are formed from carbonization of a phenolic resin or non-graphitizable polymer. An optional thermal shock resistant substrate can be included. Methods of making and using the glassy carbon coatings are further disclosed. The glassy carbon coatings are particularly useful for inclusion in metal air batteries. |
| FILED | Saturday, January 06, 2024 |
| APPL NO | 18/406134 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/24 (20130101) H01M 4/0404 (20130101) H01M 4/663 (20130101) H01M 4/667 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 12/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240225055 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changmou Xu (Lincoln, Nebraska); Rui Huang (Lincoln, Nebraska); Xiaoqing Xie (Lincoln, Nebraska) |
| ABSTRACT | The present disclosure provides suitable ingredients, added amounts, and introducing procedures (methods) for mitigating the astringency intensity, increasing the palatability, improving the physical stability, and protecting/maintaining the phenolic compounds from degradation or flocculation during storage (effects) for aronia berry compositional system. In preferred forms, the compositions of this disclosure include gum arabic and the preferred amounts thereof are based on the ratio of gum arabic to total proanthocyanidin content (TPAC) (w/w) in aronia berry compositions. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/562795 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/02 (20130101) Original (OR) Class A23L 2/56 (20130101) A23L 29/25 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226253 | GUERRERO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | FELICITO GUERRERO (PAIGE, Texas); KYLIE G BENDELE (MASON, Texas); LUISA N DOMINGUES (ATHENS, Georgia) |
| ABSTRACT | The invention relates to antigenic polypeptides derived from a naturally occurring R. microplus protein, and nucleic acids encoding such polypeptides. The polypeptides elicit an immune response which, in turn, produces detrimental effects in R. microplus feeding on vaccinated cattle. Thus, the present disclosure provides novel vaccines to protect cattle from R. microplus infestation. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0003 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/545 (20130101) A61K 2039/552 (20130101) A61K 2039/555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240228849 | Nejad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mojgan Nejad (Okemos, Michigan); Mohsen Siahkamari (East Lansing, Michigan) |
| ABSTRACT | The disclosure relates to adhesive compositions, including non-crosslinked resins and crosslinked/cured adhesives joining substrates, as well as related methods for making the compositions and articles. Compared to a conventional phenol (P) and formaldehyde (F) resin, the disclosed methods and compositions use lignin (L), formaldehyde (F), and optionally higher aldehydes (A) as corresponding replacements to provide an analog to a conventional PF resin with biobased reactants. Due to the differing reactivity of the LF components compared to the PF components, the initial condensation reaction between ortho-reactive sites in the lignin and the aldehyde is controlled to prevent gelation of the aqueous reaction mixture while reacting substantially all of the LF reactants to provide a non-crosslinked resin reaction product. The resin reaction product can then be cured at high temperature/high pressure conditions to provide a crosslinked adhesive, for example joining two substrates. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 18/275060 |
| CURRENT CPC | Manufacture by Dry Processes of Articles, With or Without Organic Binding Agents, Made From Particles or Fibres Consisting of Wood or Other Lignocellulosic or Like Organic Material B27N 1/0209 (20130101) B27N 3/002 (20130101) B27N 3/02 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 8/24 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 161/06 (20130101) C09J 197/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240232244 | Uysal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ismael Uysal (Lakeland, Florida); Alla Abdella (West Hartford, Connecticut) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude elements corresponding to the first interval; identifying a shortest data sequence corresponding to a second interval; forming a second segment of the representative data sequence based on similarity values associated with the data sequences; and concatenating the first segment and the second segment of the representative data sequence. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502620 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/353 (20190101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240225933 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Hansen (Apple Valley, Minnesota); Steve M. Morin (Minneapolis, Minnesota); Ashley Crooks (St. Cloud, Minnesota); Alexandra S. Bornstein (Minneapolis, Minnesota); Jared Bliss (Minneapolis, Minnesota) |
| ABSTRACT | An apparatus for lifting and moving a patient including a cart assembly with at least one drive wheel assembly secured thereto, a carriage assembly that is rotatably secured to the cart assembly, the carriage assembly including a lift assembly with a support arm, a patient support device operably secured to the support arm, and a counterweight assembly, the counterweight being movable along a longitudinal axis of the carriage assembly. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/493164 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 7/108 (20130101) A61G 7/1015 (20130101) Original (OR) Class A61G 7/1046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240226126 | Marinkovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Peter Marinkovich (Redwood City, California); Atul Janardhan Butte (Menlo Park, California); Mazen Nasrallah (Cambridge, Massachusetts); Marten CG Winge (Sunnyvale, California) |
| ABSTRACT | Methods of treatment for psoriasis, and compositions for use in such methods are provided, utilizing repositioned drugs identified as anti-psoriasis agents. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/568162 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/48 (20130101) A61K 31/166 (20130101) A61K 31/192 (20130101) A61K 31/404 (20130101) A61K 31/426 (20130101) A61K 31/436 (20130101) A61K 31/519 (20130101) A61K 31/4439 (20130101) A61K 31/5415 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240229148 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Baylor College of Medicine (Houston, Texas); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Northwestern University (Evanston, Illinois); The Johns Hopkins University (Baltimore, Maryland); United States Government as represented by the U.S. Department of Veterans Affairs (Washington, D. C., District of Columbia) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Baylor College of Medicine (Houston, Texas); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Northwestern University (Evanston, Illinois); The Johns Hopkins University (Baltimore, Maryland); United States Government as represented by the U.S. Department of Veterans Affairs (Washington, D.C., District of Columbia) |
| INVENTOR(S) | Jaegil KIM (Cambridge, Massachusetts); Gad GETZ (Boston, Massachusetts); Seth Paul LERNER (Houston, Texas); David KWIATKOWSKI (Boston, Massachusetts); Joshua MEEKS (Evanston, Illinois); Joaquim BELLMUNT (Cambridge, Massachusetts); David MCCONKEY (Baltimore, Maryland) |
| ABSTRACT | The present invention features methods for characterizing mutational profiles in patients with bladder cancer. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/388985 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240233891 | Malhotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devvrat Malhotra (Canton, Michigan); William Frederick Weitzel, III (Ypsilanti, Michigan); Gabriel Solomon (Ann Arbor, Michigan) |
| ABSTRACT | Methods, systems, and apparatuses are described for clinical system integration. For example, a computing device may receive a request based on one or more of a plurality of clinical systems. The computing device may retrieve, based on the request, a first plurality of interface components. The first plurality of interface components may be retrieved from each of the plurality of clinical systems in real-time. The computing device may convert the first plurality of interface components to a second plurality of interface components. The second plurality of interface components may correspond to the computing device. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406868 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240229282 | Braun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Michael Braun (San Francisco, California); Thomas Polk Moffat (Gaithersburg, Maryland); Daniel Josell (Potomac, Maryland) |
| ABSTRACT | Hysteretic current-voltage mediated void-free superconformal and bottom-up filling of recessed features includes providing an electrodeposition composition with a hysteretic cyclic voltammogram; providing the substrate controlling applied electric potential; autonomously reducing the deposition potential of the recess; bifurcating the recess; forming a transition zone and moving the transition zone through the metal deposition; and reducing metal ions to form metal; and forming a resistance enhanced superconformal filling in the recess from the metal, such that forming the resistance enhanced superconformal filling occurs in consequence of autonomously reducing the deposition potential of the recess. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 18/558324 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/38 (20130101) C25D 5/18 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/2885 (20130101) H01L 21/76898 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230415 | Klimov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolai Nikolaevich Klimov (Gaithersburg, Maryland); Tobias Kent Herman (Clarksburg, Maryland); Zeeshan Ahmed (Gaithersburg, Maryland) |
| ABSTRACT | A photonic thermometer module assembly includes: a sheath; a sheath bottom plug; a sheath top flange; a top sealing flange; a heat exchanger; a photonic thermometer disposed on the heat exchanger such that the photonic thermometer determines a temperature of the sheath; and an optical fiber array in optical communication with the photonic thermometer and that optically couples the photonic thermometer to an exterior environment of the photonic thermometer module assembly, wherein the photonic thermometer module assembly is compatible with International Temperature Scale of 0 (ITS-90) fixed-point cell infrastructure and conventional drywell and oil-bath calibrations, and the photonic thermometer module assembly provides temperature measurements from −200° C. to +700° C. |
| FILED | Tuesday, March 14, 2023 |
| APPL NO | 18/121052 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0205 (20130101) G01J 5/0821 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 15/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240235156 | Quinlan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Franklyn John Quinlan (Longmont, Colorado); Scott Alan Diddams (Louisville, Colorado); Kerry John Vahala (Pasadena, California); Joel Wei Guo (Santa Barbara, California); Chao Xiang (Santa Barbara, California); Warren B. Jin (Santa Clara, California); Charles Armand McLemore (Boulder, Colorado); Peter Thomas Rakich (New Haven, Connecticut); John Edward Bowers (Santa Barbara, California); Lin Chang (Santa Barbara, California) |
| ABSTRACT | An exemplary integrated chip-scale laser assembly includes a chip-scale laser and a compact reference optical cavity optically coupled to an output of the chip-scale laser. The compact reference optical cavity is preferably a vacuum-gap Fabry-Perot (FP) reference cavity. Coupling to the Fabry-Perot cavity from a planar waveguide circuit via bonding may be achieved with metasurfaces and/or grating couplers. The cavity may be edge-coupled to a photonic circuit with a gradient index lens. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/408456 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/026 (20130101) H01S 5/142 (20130101) Original (OR) Class H01S 5/0215 (20130101) H01S 5/02253 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240230575 | Potyrailo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York); Shiyao Shan (Clifton Park, New York) |
| ABSTRACT | A sensor system is described with improved measurement accuracy that is achieved by reducing noise, baseline drift, or both based on processing a group of sensor element response signals. The response signals may be received in response to providing stimuli to the sensor element using different excitation frequencies over time. For example, the sensor circuitry may provide excitation signals to the sensing element with multiple excitation frequencies over time. The sensor system may include storage and processing circuitry to receive the response signals and to generate the correction values based on analyzing the received response signals. The sensor system may then provide adjusted response signals by reducing the noise, baseline drift, or both based on the correction values. |
| FILED | Wednesday, October 19, 2022 |
| APPL NO | 17/969428 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/227 (20130101) G01N 27/228 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240236275 | KAIR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHERTOFF GROUP, LLC (Washington, District of Columbia); IDSS HOLDINGS, INC. (Boxborough, Massachusetts) |
| ASSIGNEE(S) | CHERTOFF GROUP, LLC (Washington, District of Columbia); IDSS HOLDINGS, INC. (Boxborough, Massachusetts) |
| INVENTOR(S) | Lee R. KAIR (Fairfax, Virginia); Jeffery J. HAMEL (Methuen, Massachusetts); Daniel S. PODER (Brookline, Massachusetts); Metin K. ALAYBEYOGLU (Clarksburg, Maryland); George M. HARDY, III (Seminole, Florida); James M. CONNELLY (Medford, Massachusetts); Edward M. OLIN, JR. (Andover, Maryland) |
| ABSTRACT | A method for remote identification of security threats in an imaged object including transmitting an initialization signal to a first threat detection scanner over a communication network, the first threat detection scanner being located at a separate physical location, receiving a ready-to-send signal from the first threat detection scanner, the ready-to-send signal including a storage location of a scan image generated by the first threat detection scanner for security inspection, receiving the scan image from the first threat detection scanner, transmitting, after receiving the scan image from the first threat detection scanner, a second initialization signal to a second threat detection scanner at the separate physical location, generating a threat detection report based on a rendering of the scan image, and transmitting the threat detection report to the first threat detection scanner. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/446235 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 11/00 (20130101) Pictorial Communication, e.g Television H04N 7/181 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240227092 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zhiyong Wang (Henderson, Nevada); Hualiang Teng (Henderson, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyong Wang (Henderson, Nevada); Hualiang Teng (Henderson, Nevada) |
| ABSTRACT | Systems and methods in which worn railroad rails and wheels are repaired. For rail repair, a mobile additive manufacturing unit (i.e., 3D printer) operates along the rail and dispenses molten metal on the previously prepared portion of the rail. Reinforcing composite materials in powder form or pieces of composite materials may be added to the molten metal to enhance mechanical properties. For wheel repair, a fixed additive manufacturing unit is used in the same or similar manner as the mobile additive manufacturing unit for the rails albeit the wheel is rotated relative to the additive manufacturing unit. The repaired surface of the rails and wheels have dimension accuracies and surface finishes that are substantially the same as the original rails and wheels with the same or better mechanical strength and hardness as the original after resurfacing with grinding or milling tools. |
| FILED | Friday, October 21, 2022 |
| APPL NO | 18/048767 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 6/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240230568 | Rajabipour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farshad Rajabipour (State College, Pennsylvania); Andrew Drach (Austin, Texas); Nima Kargah-Ostadi (Alexandria, Virginia); Gopakumar Kaladharan (State College, Pennsylvania); Kostiantyn Vasylevskyi (Nashua, New Hampshire); Borys Drach (Las Cruces, New Mexico) |
| ABSTRACT | The present invention relates in part to an embedded sensor for measuring the electrical resistivity or conductivity of pore solution in concrete materials and structures, wherein the sensor comprises a synthetic nanoporous ceramic, or nanoporous polymer, or cementitious material with controlled pore size. The present invention also relates to a method of measuring the electrical resistivity of pore solution in a concrete sample or a concrete structure. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/559400 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/20 (20130101) G01N 27/041 (20130101) Original (OR) Class G01N 27/048 (20130101) G01N 33/383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240235054 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avinash Sharma (Laurel, Maryland); Carl L. Carpenter (Annapolis, Maryland); Steven R. Szczesniak (Columbia, Maryland); David M. Lee (Hanover, Maryland); Andrew M. Lennon (Ellicott City, Maryland); Walter R. Zimbeck (Annapolis, Maryland) |
| ABSTRACT | A process for fabricating an antenna system for near Earth and Deep Space applications includes additively manufacturing an aluminum alloy powder feedstock on a build plate to form a monolithic choke ring horn antenna and a septum polarizer system layer by layer; exposing the monolithic choke ring horn antenna and the septum polarizer system on the build plate to a heat treatment process; coating nickel onto surfaces defining the monolithic choke ring horn antenna and the septum polarizer at a thickness effective to reduce surface roughness; and coating gold onto the nickel coating at a thickness effective to reduce radiofrequency loss when in use. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504722 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/364 (20130101) H01Q 21/0087 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240225003 | Mandadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kranthi Mandadi (Weslaco, Texas); Manikandan Ramasamy (Weslaco, Texas); Prakash Niraula (Weslaco, Texas); Sonia Irigoyen (Weslaco, Texas) |
| ABSTRACT | Applicants have developed novel methods and compositions for treating, preventing or ameliorating the effects plant phytopathogen infestation in plants, including of Candidatus Liberibacter spp. the causal agents of citrus greening and potato zebrachip disease. Novel compositions include one or more active agents of aminocaproic acid, carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride as well as their derivatives, or salt/acid forms thereof. Methods of preventing disease development and infestation by plant pathogens are disclosed as well as methods of making, using and producing such compositions. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615183 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/04 (20130101) A01N 33/04 (20130101) A01N 37/44 (20130101) A01N 41/10 (20130101) A01N 43/42 (20130101) A01N 43/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240235558 | Rylov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Rylov (White Plains, New York); John Francis Bulzacchelli (Somers, New York); Matthew Beck (Danbury, Connecticut) |
| ABSTRACT | A device includes a logic circuit comprising a clockless single flux quantum logic gate which comprises a plurality of input ports, an output port, an output Josephson junction, and a plurality of dynamic storage loop circuits and isolation buffer circuits. The output Josephson junction is coupled to an output of each dynamic storage loop circuit and configured to drive the output port. Each isolation buffer circuit is coupled to a respective input port, and a respective dynamic storage loop circuit and configured to absorb a circulating current of an antifluxon which is injected into the respective dynamic storage loop circuit to prevent the antifluxon from being output from the respective input port, and to inject a fluxon into the respective dynamic storage loop circuit in response to a single flux quantum pulse applied to the respective input port, and annihilate an antifluxon present in the respective dynamic storage loop circuit. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 17/971700 |
| CURRENT CPC | Pulse Technique H03K 19/20 (20130101) H03K 19/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20240232244 | Uysal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ismael Uysal (Lakeland, Florida); Alla Abdella (West Hartford, Connecticut) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude elements corresponding to the first interval; identifying a shortest data sequence corresponding to a second interval; forming a second segment of the representative data sequence based on similarity values associated with the data sequences; and concatenating the first segment and the second segment of the representative data sequence. |
| FILED | Monday, November 06, 2023 |
| APPL NO | 18/502620 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/353 (20190101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240230202 | Abraham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Abraham (Croton, New York); Gerard McVicker (Stormville, New York); Sri M. Sri-Jayantha (Ossining, New York); Vijayeshwar Das Khanna (Milwood, New York); Nicholas A. Masluk (Putnam, New York) |
| ABSTRACT | A cryogenic system comprising a first cryogenic stage and a second cryogenic stage. A first signal line passing from the first cryogenic stage and is connected to a superconducting thermal break in the second cryogenic stage. A second signal line connecting the superconducting thermal break to a cryogenic device. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445265 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 3/10 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240231075 | Ready et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Ready (Frisco, Texas); Chris Shreve (Celina, Texas); Sean G. Thomas (McKinney, Texas) |
| ABSTRACT | An optical assembly includes a primary mirror, a secondary mirror, and an optical steering system configured to support and position the primary mirror and the secondary mirror. The optical steering system includes a base and a yoke rotatably coupled to the base. The yoke is configured to support the primary mirror to rotate the primary mirror about a first axis and to support a secondary mirror to rotate the secondary mirror about a second axis. The yoke further is configured to rotate the primary and secondary mirror about a third axis. The secondary mirror is configured to move from a stowed position in which the optical assembly is positioned to receive an image from a field of view to a deployed position in which the optical assembly is positioned to receive an image from a field of regard. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094607 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/0808 (20130101) G02B 7/1821 (20130101) G02B 13/06 (20130101) G02B 26/0816 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 11, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240711.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page