FedInvent™ Patent Applications
Application Details for Thursday, July 18, 2024
This page was updated on Friday, July 19, 2024 at 04:28 PM GMT
Department of Health and Human Services (HHS)
| US 20240237898 | TANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qinggong TANG (Norman, Oklahoma); Chongle PAN (Norman, Oklahoma); Chen WANG (Norman, Oklahoma); Justin C. REYNOLDS (Norman, Oklahoma); Paul CALLE (Norman, Oklahoma); Sanjay G. PATEL (Oklahoma City, Oklahoma) |
| ABSTRACT | A method comprises: obtaining an endoscope; obtaining a needle; inserting the endoscope into the needle to obtain a system; inserting the system into an animal body; obtaining an image of a tissue or a space in the animal body using the endoscope and OCT; performing identification of the tissue or the space based on an OCT system; estimating a distance from the needle to the tissue or the space based on the identification and the OCT system; and performing a procedure with the needle and based on the identification and the distance. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428985 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Original (OR) Class A61B 5/7264 (20130101) A61B 17/3401 (20130101) A61B 17/3478 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237956 | Gong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Gong (Rochester, Minnesota); Shuai Leng (Rochester, Minnesota); Cynthia H. McCollough (Byron, Minnesota); Joel G. Fletcher (Oronoco, Minnesota) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for generating low-energy virtual monoenergetic images from multi-energy computed tomography data are provided. In some embodiments, a system comprises: at least one hardware processor configured to: receive input indicative of a particular X-ray energy level at which to generate a virtual monoenergetic image (VMI) of a subject that includes a plurality of target materials with improved contrast; receive computed tomography (CT) data of a subject; generate a VMI version of the CT data at the particular X-ray energy; and cause the VMI version of the CT data to be presented. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 18/560343 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/4241 (20130101) A61B 6/5217 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237959 | Yeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (oAKLAND, California); THE UNITED STTES GOVERNMENT AS REPRESENTED BY TH E DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin M. Yeh (Hillsborough, California); Yanjun Fu (San Francisco, California) |
| ABSTRACT | The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the encapsulated gas or partial vacuum particle contrast material into the bowel lumen with or without the delivery of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434667 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/03 (20130101) A61B 6/032 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/484 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/50 (20130101) A61K 49/0419 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237965 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sheng XU (La Jolla, California); Hongjie HU (La Jolla, California); Xiaoxiang GAO (La Jolla, California) |
| ABSTRACT | A method for determining mechanical properties of tissue in an individual includes attaching a stretchable and/or flexible ultrasound imaging device to the individual. The imaging device includes at least a one-dimensional array of transducer elements that transmit ultrasound waves into the individual. A first series of ultrasound waves are received from the tissue in the individual before applying a strain to the tissue by compression and a second series of ultrasound waves are received from the tissue after applying the compression to the tissue. Data from the first and second series of ultrasound waves are compared to obtain displacement data of the tissue from which strain data representing strain applied to the tissue is obtainable. A 2D image representing a 2D modulus distribution within the tissue is generated using the displacement data. One or more mechanical properties of the tissue is identified based on the 2D modulus distribution. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/562022 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/403 (20130101) A61B 8/485 (20130101) A61B 8/0858 (20130101) Original (OR) Class A61B 8/4488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238027 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoming He (Bethesda, Maryland); Wenquan Ou (College Park, Maryland) |
| ABSTRACT | Cancer immunotherapy deploys the host's immune system to recognize and attack cancerous tumors. However, the efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). In-situ cryo-immune engineering (ICIE) strategy turns the TME from immunologically “cold” into “hot”. In particular, after the ICIE treatment, the ratio of the CD8+ cytotoxic T cells to the immunosuppressive regulatory T cells is increased in primary tumors and distant tumors without freezing. The ICIE treatment causes “frostbite” of tumor with cold-responsive nanoparticles that target cancer cells. This rapidly releases both anticancer drug(s) and PD-L1 silencing siRNA into the cytosol. This ICIE treatment leads to potent immunogenic cell death, which promotes maturation of dendritic cells and activation of CD8+ cytotoxic T cells and memory T cells. Collectively, ICIE enables an efficient and durable way to leverage the immune system for combating cancer and its metastasis. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415331 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/02 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) A61K 38/1774 (20130101) A61K 47/10 (20130101) A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 41/00 (20180101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/56 (20130101) C08F 220/1804 (20200201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0639 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2502/1121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238198 | KENT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Craig KENT (Charlottesville, Virginia); Lian-Wang GUO (Madison, Wisconsin); Takuro SHIRASU (Charlottesville, Virginia); Bowen WANG (Charlottesville, Virginia); Shaoqin GONG (Middleton, Wisconsin); Nisakorn YODSANIT (Madison, Wisconsin) |
| ABSTRACT | In one aspect, the disclosure relates to unimolecular micelles having N-hydroxysuccinimide ester (NHS), sulfo-NHS terminal groups, or other adhesive terminal groups, compositions including the same, methods of making the same, and methods of treating intimal hyperplasia in a subject using the same. In some aspects, the unimolecular micelles can further include fluorescent labels or drugs for treating intimal hyperplasia. In one aspect, the unimolecular micelles and compositions comprising the same are biocompatible, non-toxic, and non-inflammatory. In another aspect, the unimolecular micelles and compositions are substantially free from hydrogel, or are completely free from hydrogel. In still another aspect, the disclosed compositions and methods can be easily and quickly deployed in the operating room. Also disclosed is a method of applying the unimolecular micelles and compositions via direct penbrush painting. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/562898 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/1075 (20130101) Original (OR) Class A61K 31/436 (20130101) A61K 31/7076 (20130101) A61K 49/0021 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238214 | Yeo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Yoon Yeo (West Lafayette, Indiana); Soonbum Kwon (West Lafayette, Indiana) |
| ABSTRACT | Nanoconstructs and compositions comprising a nanoparticle coated with an immunoadjuvant (e.g. ATP) and comprising one or more therapeutic agents (e.g. ICD inducer) encapsulated therein; and methods for treating cancer in a subject using such nanoconstructs and compositions, as well as combination immunotherapies. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 18/580977 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 9/5146 (20130101) Original (OR) Class A61K 9/5169 (20130101) A61K 31/337 (20130101) A61K 38/07 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238228 | FALO, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis D. FALO, Jr. (Bradfordwoods, Pennsylvania); Emrullah KORKMAZ (Pittsburgh, Pennsylvania); Tina L. SUMPTER (Murrysville, Pennsylvania) |
| ABSTRACT | Provided herein are compositions and methods of reducing inflammation in a subject comprising administering to the subject a pharmaceutically effective amount of a mast cell desensitizing composition. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 38/2066 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238243 | Ardehali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hossein Ardehali (Evanston, Illinois); Yuki Tatekoshi (Evanston, Illinois) |
| ABSTRACT | Disclosed are methods and compositions for treating or preventing heart failure with preserved ejection fraction that involve administering an O-linked N-acetylglucosamine transferase (OGT) inhibitor, for example 5S-GlcNHex, or increasing O-linked N-acetylglucosaminase (OGA) expression in endothelial cells in the heart. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412362 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/382 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238246 | Mohs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AGENEBIO, INC. (Baltimore, Maryland); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Mohs (Baltimore, Maryland); Michela Gallagher (Baltimore, Maryland); Arnold Bakker (Baltimore, Maryland) |
| ABSTRACT | Methods for preventing or slowing the progression of cognitive impairment or preventing the development or reducing the rate of cognitive decline. Methods for slowing the volumetric atrophy or reduction of a subregion of the medial temporal lobe. Methods for slowing the volumetric atrophy or reduction of the entorhinal cortex (ERC). Methods for slowing the volumetric atrophy or reduction of the transentorhinal cortex (BA35). The methods comprise administering to an APOE4 non-carrier subject one or more of levetiracetam, brivaracetam or seletracetam, or a pharmaceutically acceptable salt thereof, or administering a pharmaceutical composition comprising levetiracetam, brivaracetam or seletracetam or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411753 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/2009 (20130101) A61K 9/2013 (20130101) A61K 9/2054 (20130101) A61K 31/4015 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238254 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); The University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland); The University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Gabsang LEE (Ellicott City, Maryland); Hyungjin EOH (Baltimore, Maryland); Hojae LEE (Baltimore, Maryland); Thomas LLOYD (Baltimore, Maryland); Nicholas J. MARAGAKIS (Baltimore, Maryland) |
| ABSTRACT | Embodiments disclosed relate to methods of treating amyotrophic lateral sclerosis (ALS), including: selecting a therapeutic compound: treating an aberrant arachidonic acid (AA) metabolic pathway in an ALS cell. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/192 (20130101) A61K 31/352 (20130101) A61K 31/415 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2500/38 (20130101) C12N 2501/13 (20130101) C12N 2501/41 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238264 | MILBRANDT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (Saint Louis, Missouri); Disarm Therapeutics, Inc. (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey MILBRANDT (Saint Louis, Missouri); Kow ESSUMAN (Saint Louis, Missouri); Yo SASAKI (Brentwood, Missouri); Aaron DIANTONIO (Olivette, Missouri); Xianrong MAO (Saint Louis, Missouri); Rajesh DEVRAJ (Chesterfield, Missouri); Raul Eduardo KRAUSS (Chestnut Hill, Massachusetts); Robert Owen HUGHES (Newtown, Connecticut) |
| ABSTRACT | The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/047 (20130101) A61K 31/145 (20130101) A61K 31/198 (20130101) A61K 31/437 (20130101) A61K 31/444 (20130101) A61K 31/566 (20130101) A61K 31/4375 (20130101) A61K 31/4439 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 31/7048 (20130101) A61K 31/7084 (20130101) A61K 33/28 (20130101) A61K 33/30 (20130101) A61K 33/243 (20190101) A61K 33/245 (20130101) A61K 47/52 (20170801) A61K 47/55 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238265 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arisan Therapeutics Inc. (Carlsbad, California) |
| ASSIGNEE(S) | Arisan Therapeutics Inc. (Carlsbad, California) |
| INVENTOR(S) | Eric Brown (Santee, California); Vidyasagar Reddy Gantla (San Diego, California); Nadezda V. Sokolova (San Diego, California); Gregory Henkel (Carlsbad, California); Kenneth McCormack (Oceanside, California); Craig Robert Johnson (San Marcos, California) |
| ABSTRACT | Compounds of Structural Formulae I, II, III, IV, V, VI, VII, and VIII were developed for the treatment of Ebolavirus infection, wherein, R1, R2, R8, X, Y, Q, W, and NR3aR3b are defined in the specification. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/925579 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/165 (20130101) A61K 31/439 (20130101) A61K 31/445 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238268 | Lin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Hung Wen (Kevin) Lin (Shreveport, Louisiana) |
| ABSTRACT | Therapeutics and methods treating Alzheimer's disease or a pre-Alzheimer's disease condition in a patient comprising administering a pharmaceutical composition containing a therapeutically effective dose therapeutic, wherein the therapeutic contains a PRMT4 inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof. According to a further embodiment, the PRMT4 inhibitor is one of TP-064 and SCFFBXO9. |
| FILED | Friday, September 09, 2022 |
| APPL NO | 18/690468 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4545 (20130101) Original (OR) Class A61K 38/45 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238274 | Fang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deyu Fang (Evanston, Illinois); Elena Montauti (Evanston, Illinois); Ming Yan (Evanston, Illinois); Beixue Gao (Evanston, Illinois); Amy Tang (Evanston, Illinois); Huiping Liu (Evanston, Illinois) |
| ABSTRACT | Disclosed are methods of treating diseases or disorders associated with the expression of Ubiquitin Specific Peptidase 22 (USP22). The disclosed methods may be utilized to treat diseases or disorders associated with cell proliferation, including cancer. Also disclosed are inhibitors of USP22 that specifically inhibit the EC:3.4.19.12 activity, or the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal glycine of ubiquitin. The disclosed compounds may also be used in pharmaceutical compositions and methods for treatment of cell proliferative diseases or disorders associated with USP22 activity. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 18/556534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/37 (20130101) A61K 31/255 (20130101) A61K 31/277 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/366 (20130101) A61K 31/381 (20130101) A61K 31/435 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4418 (20130101) A61K 31/4436 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 31/4965 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238282 | Zou |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Toledo (Toledo, Ohio) |
| ASSIGNEE(S) | The University of Toledo (Toledo, Ohio) |
| INVENTOR(S) | Yue Zou (Toledo, Ohio) |
| ABSTRACT | Combination treatments for cancers involving inhibiting cis-ATR, as well as biomarkers for cancer diagnosis and prognosis, and transgenic animals, are described. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 18/557651 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2217/052 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238289 | Nath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Karl A. Nath (Rochester, Minnesota); James L. Kirkland (Rochester, Minnesota); Tamar Tchkonia (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/355 (20130101) A61K 31/506 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238310 | Bulun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Serdar E. Bulun (Chicago, Illinois); Hong Zhao (Wilmette, Illinois) |
| ABSTRACT | Disclosed are methods and compositions for treating and/or preventing hernias in subjects in need thereof. The disclosed methods of treatment and/or preventing may include methods for treating and/or preventing hernias in subject in need thereof by administering to the subject a therapeutic agent that modulates sex steroid hormone production and/or activity in the subject. Hernias treated and/or prevented by the disclosed methods may include, but are not limited to, inguinal hernias, femoral hernias, umbilical hernias, hiatal hernias, incisional hernias, and diastasis recti. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434367 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0063 (20130101) A61F 2250/0067 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/56 (20130101) A61K 31/566 (20130101) A61K 31/4196 (20130101) A61K 31/4535 (20130101) A61K 31/5685 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238318 | LE-LAU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric K. LE-LAU (Tampa, Florida) |
| ABSTRACT | Disclosed are methods for treating, inhibiting, reducing, and/or preventing cancers (such as, for example melanoma) and/or metastasis (such as, for example metastatic melanoma) comprising administering to a subject a L-fucose and an anti-androgen therapy. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559204 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/167 (20130101) A61K 31/277 (20130101) A61K 31/496 (20130101) A61K 31/573 (20130101) A61K 31/4166 (20130101) A61K 31/4439 (20130101) A61K 31/7004 (20130101) Original (OR) Class A61K 38/09 (20130101) A61K 39/3955 (20130101) A61K 39/4611 (20230501) A61K 39/4613 (20230501) A61K 39/4631 (20230501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/723 (20130101) G01N 2333/91102 (20130101) G01N 2440/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238338 | Kipnis |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Jonathan Kipnis (St. Louis, Missouri) |
| ABSTRACT | Compositions and methods for the treatment, prevention, or reversal of a central nervous system (CNS) injury or disorder in a patient in need that include administering a therapeutically effective amount of meningeal immune cells are disclosed. Specifically, the meningeal immune cells comprise Ly6C+ monocytes. Further disclosed are wherein the meningeal immune cells are modified to include a drug or gene therapeutic compound, and wherein the modified meningeal immune cells are configured to deliver the drug or gene therapeutic compound to the CNS of the subject via the parenchyma or meningeal tissue of the subject. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/560263 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238339 | Childs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Richard W. Childs (Rockville, Maryland); David S.J. Allan (Rockville, Maryland); Chantiya Chanswangphuwana (Bangkok, Thailand) |
| ABSTRACT | Modified natural killer (NK) or T cells expressing hematopoietic growth factor receptors are provided. In some embodiments, the NK cells or T cells express a thrombopoietin receptor or an erythropoietin receptor. Methods of treating a subject with cancer are also provided, including administering the modified NK cells or T cells to the subject in combination with a thrombopoietin receptor agonist or erythropoietin receptor agonist, and in some example, interleukin-2, particularly reduced or low-dose amounts of IL-2. |
| FILED | Monday, January 29, 2024 |
| APPL NO | 18/425487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238340 | Sant'Angelo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Derek B. Sant'Angelo (New Brunswick, New Jersey); Lisa K. Denzin (New Brunswick, New Jersey) |
| ABSTRACT | The present disclosure includes compositions and methods for treating gastrointestinal inflammatory disease and/or cancers. In certain aspects, the disclosure includes an isolated cell comprising a nucleic acid vector comprising a gene encoding the transcription factor ZBTB20 which is operably linked to a promoter. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/558644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/464452 (20230501) A61K 2239/31 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) Peptides C07K 14/4705 (20130101) C07K 14/5428 (20130101) C07K 16/2818 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/4706 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) G01N 2800/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238346 | MOHSIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Temple University - of the Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadia MOHSIN (Philadelphia, Pennsylvania); Steven HOUSER (Philadelphia, Pennsylvania); Hajime KUBO (Philadelphia, Pennsylvania) |
| ABSTRACT | Cell therapies and cell secretome compositions are utilized in the methods of treatment of cardiac injury. The compositions mediate myocardial homeostasis and cardiac wound healing process post-MI via the direct modulation of regulatory T cell (Treg) population dynamics and function. |
| FILED | Friday, July 08, 2022 |
| APPL NO | 18/577300 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/1754 (20130101) A61K 38/1793 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238347 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Mandeep Singh (Baltimore, Maryland); Robert Johnston (Baltimore, Maryland); Kiara Eldred (Baltimore, Maryland); Katarzyna Hussey (Baltimore, Maryland); Sarah Hadyniak (Baltimore, Maryland); Christina McNerney (Baltimore, Maryland) |
| ABSTRACT | The present disclosure relates to cell-based therapeutics for retinal and macular repair comprising defined retinal cell subtypes, including short (s)-, medium (m)- and long (l) wavelength sensitive cone photoreceptors, methods for the manufacture of such cell-based therapeutics, and methods of using such therapeutics. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/581734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238350 | Hsiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Hsiao (Los Angeles, California); Jessica Yano (Los Angeles, California); Helen Vuong (Los Angeles, California); Christine Olson (Los Angeles, California) |
| ABSTRACT | Provided herein are methods and compositions related to treating or preventing seizures. In some aspects, provided herein are methods of treating or preventing seizures in a subject by administering to the subject a composition comprising Parabacteroides and Akkermansia bacteria. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390652 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/30 (20160801) A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0053 (20130101) A61K 35/74 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 39/0216 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238363 | RUFF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Creative Bio-Peptides, Inc. (Potomac, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R. RUFF (Potomac, Maryland); Gilah ROSNER (Potomac, Maryland) |
| ABSTRACT | The present invention relates, broadly, to the improvement of cognition by methods to shift neurons from a state or condition of loss of synapses and dendritic spines to one of formation/regeneration of synapses and dendritic spines. A novel mechanism appears to control a neuronal stress response and improve memory and learning by rebalancing synapse and dendritic spine dynamics to favor their formation. Methods are disclosed to enhance the number of functioning synapses and dendritic spines which is expected to improve overall cognitive function. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/512201 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) Original (OR) Class A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238369 | Marshall |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALDER BIOSCIENCES INC. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Patrick Marshall (New York, New York) |
| ABSTRACT | The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/455787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16051 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238370 | Oka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuki Oka (Pasadena, California); Sangjun Lee (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods and compositions for modulating sodium appetite and/or intake. In some embodiments, the sodium appetite of a subject is reduced. Also disclosed include methods for identifying modulators for sodium appetite and/or intake. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431197 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238379 | Denny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York); The Research Foundation for Mental Hygiene, Inc. (Menands, New York) |
| INVENTOR(S) | Christine A. Denny (Ho-Ho-Kus, New Jersey); Briana K. CHEN (New York, New York) |
| ABSTRACT | Compositions and methods for the prevention and treatment of stress-induced fear, depressive-like and anxiety-like behavior using selective VPAC2 agonist Bay 55-9837. |
| FILED | Friday, December 29, 2023 |
| APPL NO | 18/400120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2278 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/22 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238386 | Shapiro et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marshall University Research Corporation (Huntington, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph I. Shapiro (Huntington, West Virginia); Jiang Liu (Huntington, West Virginia) |
| ABSTRACT | Methods for treating anemia are provided and include the steps of identifying a subject as having anemia characterized by a reduced number of red blood cells and then administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to the subject. Methods for increasing red blood cell half-life are also provided in which the polypeptide antagonist of a Na/K ATPase/Src receptor complex is either administered to a subject in need thereof or is made to contact a red blood cell. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/560230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/46 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238388 | Wagner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Denisa D. Wagner (Dover, Massachusetts); Tobias A. Fuchs (Gunzenbach, Germany); Simon De Meyer (Zwevegem, Belgium); Kimberly Martinod (Boston, Massachusetts); Alexander Brill (Birmingham, United Kingdom); Grace M. Thomas (Marseille, France) |
| ABSTRACT | Embodiments of the technology described herein are based upon the discoveries that neutrophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries. |
| FILED | Monday, October 16, 2023 |
| APPL NO | 18/380292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/166 (20130101) A61K 38/49 (20130101) A61K 38/465 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/34 (20130101) A61M 1/0209 (20130101) Enzymes C12Y 301/21001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238396 | Brogdon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Novartis AG (Basel, Switzerland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Brogdon (Sudbury, Massachusetts); Laura Alexandra Johnson (Media, Pennsylvania); Carl H. June (Merion Station, Pennsylvania); Andreas Loew (Boston, Massachusetts); Marcela Maus (Lexington, Massachusetts); John Scholler (Narberth, Pennsylvania); Hideho Okada (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/505864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 39/001102 (20180801) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/2863 (20130101) C07K 16/3053 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238403 | Kawaoka et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Gabriele Neumann (Madison, Wisconsin); Lizheng Guan (Madison, Wisconsin) |
| ABSTRACT | As described herein, influenza A viruses were developed that replicate to high titers in cultured cells and/or embryonated chicken eggs. Mutations were identified that resulted in higher virus titers in cultured cells and/or embryonated chicken eggs, allowing more efficient influenza virus growth and more cost-effective vaccine production. Replication-enhancing residues include, but are not limited to, PB2 439H, PB1 577R, PB1 640V, M1 35R, PB1 62E, and/or PB1 624I, or combinations thereof. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/55 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16121 (20130101) C12N 2760/16134 (20130101) C12N 2760/16151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238405 | Stamatatos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER CENTER (Seattle, Washington) |
| ASSIGNEE(S) | FRED HUTCHINSON CANCER CENTER (Seattle, Washington) |
| INVENTOR(S) | Leonidas Stamatatos (Seattle, Washington); Andrew McGuire (Seattle, Washington); Katherine Rachael Parks (Seattle, Washington); Matthew D. Gray (Seattle, Washington) |
| ABSTRACT | Sequential immunization strategies to guide the maturation of antibodies against the human immunodeficiency virus (HIV) are described. The sequential immunization strategies utilize an HIV envelope protein (Env) that binds germline (gl) B cells as a first (prime) immunization and an Env with a functional glycosylated N276 as a second (boost) immunization. The sequential immunization strategies successfully elicit neutralizing antibodies against HIV. |
| FILED | Tuesday, January 02, 2024 |
| APPL NO | 18/402480 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/02 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16034 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238414 | Davis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Prommune, Inc. (Topeka, Kansas); Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Davis (Omaha, Nebraska); Samer Al-Murrani (Topeka, Kansas) |
| ABSTRACT | Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/002 (20130101) A61K 39/005 (20130101) A61K 39/008 (20130101) A61K 39/012 (20130101) A61K 39/015 (20130101) A61K 39/018 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/627 (20130101) A61K 2039/6031 (20130101) A61K 2039/55516 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238415 | LEE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Brendan LEE (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods for treating and improving moderate-to-severe osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of an agent that binds and neutralizes transforming growth factor beta (TGFβ). |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 18/559261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/663 (20130101) A61K 38/23 (20130101) A61K 38/29 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 47/645 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) Peptides C07K 16/22 (20130101) C07K 2317/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238418 | Sayour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elias Sayour (Newberry, Florida); Jianping Huang (Gainesville, Florida); Hector Ruben Mendez-Gomez (Gainesville, Florida); Paul Antonio Castillo Caro (Gainesville, Florida); Ruixuan Liu (Gainesville, Florida) |
| ABSTRACT | The disclosure provides a method of preconditioning a subject for chimeric antigen receptor (CAR) T cell therapy. The method comprises administering to the subject a composition comprising a nanoparticle comprising a positively-charged surface and an interior comprising (i) a core and (ii) at least two nucleic acid layers, wherein each nucleic acid layer is positioned between a cationic lipid bilayer, at least one day prior to administering CAR T cell therapy to the subject. The disclosure also provides a method of treating a solid tumor in a subject, the method comprising administering to a subject comprising a surface antigen negative solid tumor a first composition comprising the nanoparticle, wherein the nucleic acid within the nanoparticle encodes the surface antigen, and a second composition comprising a CAR T cell that targets the surface antigen. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289705 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 39/4611 (20230501) Original (OR) Class A61K 39/4631 (20230501) A61K 39/464429 (20230501) A61K 2239/39 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238421 | PAYNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin A. PAYNE (Denver, Colorado); Melissa D. KREBS (Englewood, Colorado) |
| ABSTRACT | The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392543 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/16 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 47/22 (20130101) A61K 47/36 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 2300/62 (20130101) A61L 2300/256 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2300/416 (20130101) A61L 2430/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 16/22 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2305/04 (20130101) C08J 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238438 | Parhiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania); Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamideh Parhiz (Gladwyne, Pennsylvania); Drew Weissman (Philadelphia, Pennsylvania); Hans-Peter Kiem (Seattle, Washington); Stefan Radtke (Seattle, Washington); Christopher Peterson (Seattle, Washington) |
| ABSTRACT | The present invention relates to compositions and methods for effective delivery of an agent to a stem cell using a delivery vehicle, such as a lipid nanoparticle (LNP), comprising a CD90 targeting domain. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/558014 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 47/6849 (20170801) Original (OR) Class A61K 47/6925 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238448 | Hathaway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel Hathaway (Chapel Hill, North Carolina); Matthew Hirsch (Chapel Hill, North Carolina); Jessica Umana (Durham, North Carolina); Liujiang Song (Chapel Hill, North Carolina) |
| ABSTRACT | This invention relates to methods and compositions for gene therapy. In particular, the invention relates to methods and compositions for modulating transgene expression from transgene delivery vectors by recruiting epigenetic modifiers to the vector. Using these methods, transgene delivery vectors can be more precisely regulated to produce increased amounts of the transgene product when needed and to decrease expression when needed, thereby providing maximum benefits for gene therapy while minimizing toxicity. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/558886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 48/0066 (20130101) Original (OR) Class Peptides C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238451 | Verkhusha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York); University of Helsinki (Helsingin Yliopisto, Finland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladislav V. Verkhusha (Bronx, New York); Olena S. Oliinyk (Helsinki, Finland) |
| ABSTRACT | Provided herein are fusion proteins comprising a single domain antibody (sdAb) (including, but not limited to, a nanobody) that binds selectively to a specific antigen, wherein a second polypeptide is inserted into the single domain antibody, generating an internal fusion. Also provided are methods of making and methods of using the fusion proteins disclosed herein. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/561653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0045 (20130101) A61K 49/0058 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) C07K 16/1003 (20230801) C07K 2317/31 (20130101) C07K 2317/569 (20130101) C07K 2319/30 (20130101) C07K 2319/60 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238459 | Craik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles S. Craik (San Francisco, California); Conner Bardine (San Francisco, California); Michael Evans (San Francisco, California) |
| ABSTRACT | The present disclosure provides granzyme-activatable and detectable membrane-interacting peptides that, following activation, can interact with phospholipid bilayers, such as cell membranes. The present disclosure also provides methods of use of such peptides, as well as compositions comprising such peptides. The peptides of the present disclosure are of the general structure X1a-A-X2—Z—X1b, where A is a membrane-interacting peptide region having a plurality of nonpolar hydrophobic amino acid residues that, following separation from portions Z, is capable of interaction with a phospholipid bilayer; Z is an inhibitory peptide region that can inhibit the activity of portion A; X2 is a granzyme-cleavable linker that can be cleaved to release cleavage products from the compound; and X1a and X1b are optionally-present chemical handles that facilitate conjugation of various cargo moieties to the compound. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/563182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/65 (20170801) A61K 49/0032 (20130101) A61K 49/0056 (20130101) A61K 51/088 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238486 | Falo, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Louis D. Falo, Jr. (Wexford, Pennsylvania); Geza Erdos (Wexford, Pennsylvania); O. Burak Ozdoganlar (Sewickley, Pennsylvania) |
| ABSTRACT | A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/454628 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 31/042 (20130101) A61L 31/148 (20130101) Original (OR) Class A61L 2300/426 (20130101) A61L 2300/604 (20130101) A61L 2400/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) A61M 2037/0053 (20130101) Milling B23C 3/00 (20130101) B23C 2215/00 (20130101) B23C 2220/48 (20130101) B23C 2226/00 (20130101) Technical Subjects Covered by Former US Classification Y10T 409/303752 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238594 | Fried et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Itzhak FRIED (Los Angeles, California); Yuval NIR (Tel-Aviv, Israel); Maya GEVA-SAGIV (Los Angeles, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); RAMOT AT TEL AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296 Tel-Aviv 6139201 (IL) (Tel-Aviv, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Itzhak Fried (Los Angeles, California); Yuval Nir (Tel Aviv, Israel); Maya Geva-Sagiv (Oakland, California) |
| ABSTRACT | A closed-loop neuromodulatory system comprises one or more processors and memory. The system is configured to record signals from a first region of a brain of a human subject during sleep via a first electrode. The system is configured to determine, from the recorded signals, active periods of the first region. The system is configured to stimulate a second region of the brain, different from the first region, during the active periods via a second electrode that is electrically coupled to the first electrode via closed-loop control. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563692 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36064 (20130101) A61N 1/36092 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/36171 (20130101) A61N 1/36175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238616 | VERHAAK |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roel VERHAAK (Farmington, Connecticut) |
| ABSTRACT | The invention relates, in part, to methods and compounds for radiosensitizing cells and increasing efficacy of treatments for cancers. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563207 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1001 (20130101) Original (OR) Class A61N 5/1077 (20130101) A61N 2005/1024 (20130101) A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238776 | Singer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HelixBind, Inc. (Boxborough, Massachusetts) |
| ASSIGNEE(S) | HelixBind, Inc. (Boxborough, Massachusetts) |
| INVENTOR(S) | Alon Singer (Concord, Massachusetts); Ranjit Prakash (Northborough, Massachusetts) |
| ABSTRACT | Fluidic devices and related methods are generally provided. The fluidic devices described herein may be useful, for example, for diagnostic purposes (e.g., detection of the presence of one or more disease causing bacteria in a patient sample). Unlike certain existing fluidic devices for diagnostic purposes, the fluidic devices and methods described herein may be useful for detecting the presence of numerous disease causing bacteria in a patient sample substantially simultaneously (e.g., in parallel). In some embodiments, the fluidic devices and methods described herein provide highly sensitive detection of microbes in relatively large fluidic samples (e.g., between 0.5 mL and about 5 mL), as compared to certain existing fluidic detection (e.g., microfluidic) devices and methods. In an exemplary embodiment, increased detection sensitivity of microbial pathogens present in a patient sample (e.g., blood) is performed by selectively removing human nucleic acid prior to sensitive detection of microbial infection. In some embodiments, the fluidic device allows for the identification of microbial pathogens directly from unprocessed blood without having to conduct blood culturing processes. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/616649 |
| CURRENT CPC | Separation B01D 63/088 (20130101) B01D 69/02 (20130101) B01D 71/34 (20130101) B01D 2325/20 (20130101) B01D 2325/38 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 3/5027 (20130101) B01L 7/52 (20130101) B01L 2200/16 (20130101) B01L 2200/0673 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/087 (20130101) B01L 2300/166 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2300/1827 (20130101) B01L 2400/06 (20130101) B01L 2400/049 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238787 | Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akhenaton-Andrew Jones (Durham, North Carolina); Sarah Kate Childs (Durham, North Carolina) |
| ABSTRACT | A lid for an assay. The lid including a peg coupled to the lid. The peg including a first end coupled to the lid, a second end opposite the first end, a longitudinal axis that extends between the first end and the second end, a first portion extending from the first end towards the second end and having a first outer dimension, a second portion extending from the second end towards the first end and having a second outer dimension, and a third portion positioned between the first portion and the second portion, the third portion having a third outer dimension that is smaller than the first outer dimension and greater than the second outer dimension, a surface of the third portion defining a step between the first end and the second end. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411564 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 2300/041 (20130101) B01L 2300/0829 (20130101) B01L 2300/0848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239738 | Silverman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. Silverman (Evanston, Illinois); Wei Zhu (Evanston, Illinois) |
| ABSTRACT | Disclosed are amino-substituted, halomethylene-substituted cyclohexene carboxylic acid compounds and amino-substituted. halomethylene-substituted cyclohexane carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating human ornithine aminotransferase (AO AT) activity, including methods for treating diseases or disorders associated with AO AT activity or expression such as cell proliferative diseases and disorders including cancer. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/554265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) Acyclic or Carbocyclic Compounds C07C 229/48 (20130101) Original (OR) Class C07C 2601/14 (20170501) C07C 2601/16 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239764 | WHITEHEAD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mekanistic Therapeutics (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher WHITEHEAD (Ann Arbor, Michigan); Judith LEOPOLD (Ann Arbor, Michigan) |
| ABSTRACT | This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof, wherein the variables Ring A, X, R1a, R1b, R2, R3, R4, m, n, and p are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The disclosure further relates to the use of the compounds described herein as therapeutics for the treatment of diseases and conditions mediated by EGFR proteins and/or PI3K proteins, such as cancer and other diseases. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 18/258746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/497 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4709 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/54 (20130101) C07D 239/94 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 401/10 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/10 (20130101) C07D 405/14 (20130101) C07D 413/04 (20130101) C07D 413/10 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239774 | Balbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York); Tri-Institutional Therapeutics Discovery Institue, Inc. (New York, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York); Tri-Institutional Therapeutics Discovery Institue, Inc. (New York, New York) |
| INVENTOR(S) | Melanie Balbach (New York, New York); Jochen Buck (Old Greenwich, Connecticut); Lonny R. Levin (New York, New York); Jonathan Hale Zippin (Scarsdale, New York); Clemens Steegborn (Bayreuth, Germany); Makoto Fushimi (Harrison, New York); David John Huggins (New York, New York); Nigel Liverton (Harleysville, Pennsylvania); Peter T. Meinke (Scotch Plains, New Jersey); Mayako Michino (New York, New York); Michael Miller (Scotch Plains, New Jersey) |
| ABSTRACT | Provided herein are soluble adenylyl cyclase (sAC) inhibitors and uses thereof. In one aspect, provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and pharmaceutical compositions thereof. The compounds provided herein are soluble adenylyl cyclase (sAC) inhibitors and are therefore useful for the treatment and/or prevention of various diseases and conditions (e.g., ocular conditions (e.g., ocular hypotony), liver diseases (e.g., non-alcoholic steatohepatitis (NASH)), inflammatory diseases, autoimmune diseases (e.g., psoriasis)). Compounds provided herein are also useful as contraceptive agents (e.g., for male and female contraception). |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/288368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5377 (20130101) A61K 31/5386 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) A61P 29/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) Original (OR) Class C07D 413/14 (20130101) C07D 417/14 (20130101) C07D 491/107 (20130101) C07D 498/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239805 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manvendra Pal Singh (Lawrence, Kansas); Zarko Boskovic (Lawrence, Kansas); Bryce Gaskins (Lawrence, Kansas) |
| ABSTRACT | The present disclosure is directed to a compound of Formula I, Formula II, Formula III, Formula IV, or Formula V or a pharmaceutically acceptable salt and/or solvate thereof. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541565 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 491/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239810 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Rapafusyn Pharmaceuticals, Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Liu (Clarksville, Maryland); Sam Hong (Baltimore, Maryland); Brett R. Ullman (Baltimore, Maryland); Joseph E. Semple (Baltimore, Maryland); Kana Yamamoto (Baltimore, Maryland); Puneet Kumar (Baltimore, Maryland); Magesh Sadagopan (Baltimore, Maryland); Jennifer C. Schmitt (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocycles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584888 |
| CURRENT CPC | Heterocyclic Compounds C07D 498/04 (20130101) C07D 498/14 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239821 | DOWD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia S. DOWD (Washington, District of Columbia); Kenneth HEIDEL (Washington, District of Columbia); Audrey R. Odom JOHN (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure relates to novel compounds useful as antimicrobial agents. The present disclosure also relates to processes for their preparation, pharmaceutical compositions comprising them, and to their use in methods for treating or preventing microbial infections caused by parasites or bacteria, such as, for example, Plasmodium falciparum or related Plasmodium parasite species, Mycobacterium tuberculosis or related Mycobacterium bacteria species, S aureus, and ESKAPE pathogens. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559017 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 57/04 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 13/00 (20210801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3826 (20130101) C07F 9/4015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239823 | STAINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); NUTECH VENTURES (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cliff STAINS (Crozet, Virginia); Yuan FANG (Charlottesville, Virginia); Ruwen YIN (Charlottseville, Virginia); Frederik BRONDSTED (Charlottesville, Virginia); Xinqi ZHOU (Charlottesville, Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to xanthene-, thiazine-, and oxazine-based dyes containing a phosphinate ester group and having near-infrared (NIR) absorption and methods of making the same. The fluorescence lifetimes and stabilities of the dyes can be tuned by modifying the molecule cores, making them suitable for a variety of chemical labeling, imaging, and other theranostic applications. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/556703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/548 (20170801) A61K 49/0021 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65846 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239851 | PELLEGRINI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria PELLEGRINI (Hanover, New Hampshire); Adam H. BARCZEWSKI (Hanover, New Hampshire); Gevorg GRIGORYAN (Hanover, New Hampshire) |
| ABSTRACT | The present disclosure relates to a modified NEMO protein that, inter alia, allows for structural determination of the NEMO protein in the apo-form and in complex with a ligand by NMR or X-ray crystallography. The present disclosure also relates to the use of such modified NEMO proteins to screen and validate inhibitors of the interaction between NEMO and IKKα and/or IKKβ and for structure determination of NEMO in the apo-form and in complex with a ligand, preferably by NMR or X-ray crystallography. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514761 |
| CURRENT CPC | Peptides C07K 14/4703 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239857 | Puri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Silver Spring, Maryland) |
| INVENTOR(S) | Raj K. Puri (Urbana, Maryland); Bharatkumar H. Joshi (Bethesda, Maryland) |
| ABSTRACT | The disclosure relates to immunotoxins, particularly immunotoxins useful for treating IL-13Rα2 expressing cancer, or reducing perineural invasion by an IL-13Rα2 expressing cancer. Immunotoxins that specifically bind IL-13Rα2, nucleic acids encoding the immunotoxins, vectors including the nucleic acids encoding the immunotoxins, and host cells expressing the immunotoxins are provided. Also provided are pharmaceutical compositions including the immunotoxin and methods of treating a subject with cancer, including administering to the subject the immunotoxin alone or in combination with other cancer therapies. Also provided are methods of reducing perineural invasion (PNI) and reducing pain associated with PNI, by administering a therapeutically effective amount of the immunotoxin or IL-13-PE immunotoxin. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/562128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6817 (20170801) A61K 47/6849 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4747 (20130101) C07K 14/5437 (20130101) Original (OR) Class C07K 2319/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239864 | Ishii et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kazusa Ishii (Bethesda, Maryland); Christian Hinrichs (Bethesda, Maryland) |
| ABSTRACT | Disclosed are isolated or purified T cell receptors (TCRs), wherein the TCRs have antigenic specificity for a CD22 amino acid sequence presented by a human leukocyte antigen (HLA) Class I molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/277521 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464413 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239869 | Chour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Institute for Systems Biology (Seattle, Washington); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | William Chour (San Gabriel, California); James R. Heath (Seattle, Washington); Jingyi Xie (Seattle, Washington) |
| ABSTRACT | Peptide-major histocompatibility (MHC) Class I nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289674 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4632 (20230501) Peptides C07K 14/70539 (20130101) Original (OR) Class C07K 2319/01 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239873 | Sullivan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Nancy Sullivan (Brookline, Massachusetts); Kendra Leigh (Frederick, Maryland); John Misasi (Kensington, Maryland); Alberto Cagigi (Stockholm, Sweden) |
| ABSTRACT | Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/619995 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) G01N 2400/02 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239874 | Smith |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Smith (Norman, Oklahoma) |
| ABSTRACT | The present invention includes antibodies and antigen-binding fragments thereof that specifically bind a SARS-CoV-2 antigen and are in certain embodiments capable of neutralizing a SARS-CoV-2 infection. Polynucleotides encoding an antibody or an antigen-binding fragment, vectors and host cells that comprise a polynucleotide and pharmaceutical compositions are also included in this invention. Also described herein are methods of using the presently disclosed antibodies, antigen-binding fragments, polynucleotides, vectors, host cells, and compositions to diagnose, prevent or treat a SARS-CoV-2 infection. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 47/6911 (20170801) A61K 47/6929 (20170801) A61K 49/0058 (20130101) A61K 51/1006 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239899 | DAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Sloan-Kettering Institute for Cancer Research (New York, New York); Memorial Hospital for Cancer and Allied Diseases (New York, New York); Tri-Institutional Therapeutics Discovery Institute, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao DAO (New York, New York); David A. SCHEINBERG (New York, New York); Paul BALDERES (New York, New York); Mary Ann POHL (New York, New York) |
| ABSTRACT | The present technology relates generally to compositions that specifically recognize and bind to a serine-phosphorylated IRS2 (pIRS2) peptide RVA[pS]PTSGVK (SEQ ID NO: 19) complexed with a major histocompatibility antigen (e.g., HLA-A*02). The compositions of the present technology are useful in methods for treating pIRS2-associated diseases (e.g., cancers) in a subject in need thereof. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/561699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/217 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/70503 (20130101) C07K 16/2833 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/622 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239901 | Seibold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max A. Seibold (Denver, Colorado); Jamie L. Everman (Denver, Colorado) |
| ABSTRACT | Disclosed herein are methods/uses as well as compositions for reducing airway mucus obstruction, mucus plugging and/or airway inflammation by administering to a subject in need thereof, an intelectin-1 (ITLN-1) inhibitor. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412165 |
| CURRENT CPC | Peptides C07K 16/2851 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239903 | DONNELLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Linda DONNELLY (Arlington, Texas); Xiaofeng QI (Dallas, Texas); Xiaochun LI (Dallas, Texas) |
| ABSTRACT | Disclosures herein are directed to antibodies and epitope binding agents that specifically bind to the extracellular domain of Patched-1 and compositions thereof for use in clinical and non-clinical applications. Also provided are methods to treat and/or prevent Hedgehog pathway related disorders. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2800/7057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239912 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Tobias V. Lanz (Stanford, California); Samuel J. Rubin (Menlo Park, California) |
| ABSTRACT | The present invention relates to novel bi-specific antigen-binding polypeptides and their preparation and use in the treatment and/or diagnosis of various diseases, and also relates to bi-specific antibody molecules capable of inhibiting immune effector cells and their use in diagnosis and/or treatment of various diseases. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/917523 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/04 (20180101) A61P 37/00 (20180101) Peptides C07K 16/283 (20130101) C07K 16/2803 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239913 | SCANZELLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); OKLAHOMA MEDICAL RESEARCH FOUNDATION (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CARLA R. SCANZELLO (Philadelphia, Pennsylvania); TIMOTHY GRIFFIN (Oklahoma City, Oklahoma) |
| ABSTRACT | Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 14/7455 (20130101) C07K 16/2896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Enzymes C12Y 207/12002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240150 | Skardal |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksander Skardal (Dublin, Ohio) |
| ABSTRACT | A method of making a cardiac construct is carried out by depositing a mixture comprising live mammalian cardiac cells (e.g., individual cells, organoids, or spheroids), fibrinogen, gelatin, and water on a support to form an intermediate cardiac construct; optionally co-depositing a structural support material (e.g., polycaprolactone) with the mixture in a configuration that supports the intermediate construct; and then contacting thrombin to the construct in an amount effective to cross-link the fibrinogen and produce a cardiac construct comprised of live cardiac cells that together spontaneously beat in a fibrin hydrogel. Constructs made and methods of using the same are also described. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538015 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/01 (20130101) C12M 29/00 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 5/067 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 5/0671 (20130101) C12N 2501/999 (20130101) C12N 2502/14 (20130101) C12N 2502/1329 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/80 (20130101) C12N 2533/90 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240154 | Wells et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wells (Cincinnati, Ohio); Jorge Orlando Munera (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for the in vitro differentiation of a precursor cell into definitive endoderm, which may further be differentiated into a human colonic organoid (HCO), via modulation of signaling pathways. Further disclosed are HCOs and methods of using HCOs, which may be used, for example, for the HCOs may be used to determine the efficacy and/or toxicity of a potential therapeutic agent for a disease selected from colitis, colon cancer, polyposis syndromes, and/or irritable bowel syndrome. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/473619 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/113 (20130101) C12N 2501/115 (20130101) C12N 2501/117 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240173 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Stanford, California); Yann Chong Tan (Stanford, California); Jeremy Sokolove (Stanford, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529287 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240180 | Flotte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Terence Flotte (Worcester, Massachusetts); Christian Mueller (Worcester, Massachusetts); Phillip D. Zamore (Worcester, Massachusetts) |
| ABSTRACT | The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency). |
| FILED | Tuesday, January 30, 2024 |
| APPL NO | 18/426444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 35/12 (20130101) A61K 38/57 (20130101) A61K 48/005 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/8125 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/67 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/3519 (20130101) C12N 2320/31 (20130101) C12N 2750/14121 (20130101) C12N 2750/14132 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240181 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Anderson (Belmont, Massachusetts); Pavel Ivanov (Brighton, Massachusetts); Mohammed Emara (Newton, Massachusetts) |
| ABSTRACT | Provided herein are neuroprotective molecules containing a sequence of 25-35 contiguous nucleotides between nucleotide 1 and nucleotide 50 of a mature human tRNA and at least four contiguous guanosine-containing nucleotides, where the sequence of 25-35 contiguous nucleotides contains a D-loop stem structure, the at least four contiguous guanosine-containing nucleotides are located at the 5′ end of the neuroprotective molecule, and the neuroprotective molecule contains at least one deoxyribonucleotide. Also provided are neuroprotective molecules containing a sequence of 25-35 contiguous nucleotides between nucleotide 1 and nucleotide 50 of a mature human tRNACYS; and at least four contiguous guanosine-containing nucleotides, where the sequence of 25-35 contiguous nucleotides contains a D-loop stem structure and the at least four contiguous guanosine-containing nucleotides are located at the 5′ end of the neuroprotective molecule. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507432 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/18 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240185 | Mehle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Mehle (Madison, Wisconsin); Cason King (, None) |
| ABSTRACT | Described herein are compositions and methods for a screening approach for identifying host factors that impact influenza viral production after the initial infection. Host factors that enhance influenza virus production were identified. Screening methods described herein include variations of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system, termed CRISPR activation (CRISPRa) and CRISPR inhibition (CRISPRi). |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/516385 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1131 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/10 (20130101) C12N 2760/16151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240189 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Qiang LU (Duarte, California); Runxiang QIU (Duarte, California) |
| ABSTRACT | A method of treating cancer in a subject by targeting at least one of KIF20A, SEPT7, RGS3 and EphrinB or disrupting protein-protein interaction in the EPHRINB-RGS3-KIF20A-SEPT7 axis. The method entails administering to the subject an RNA-based inhibitor such as an siRNA, shRNA, or miRNA or a peptide inhibitor which targets at least one of KIF20A, SEPT7, RGS3 and EphrinB or blocks the binding of KID20A to RGS3 and/or SEPT7 or the binding of EphrinB and RGS3. |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/554286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240205 | WARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian M. WARD (Pittsford, New York); Stephanie MONTICELLl (Frederick, Maryland); Peter BRYK (Rochester, New York) |
| ABSTRACT | A method for inducing an immune response to an antigen in a subject is disclosed. The method comprises the step of administering to the subject an effective amount of a recombinant vaccinia virus in which the coding sequence for the extracellular virion protein F13 has been replaced with the coding sequence for MC021, a molluscum contagiosum virus homolog of F13, wherein the recombinant vaccinia virus comprises a nucleic acid encoding an immunogenic epitope of the antigen. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/560338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/5254 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240207 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); James Angstman (Charlestown, Massachusetts); Shengdar Tsai (Memphis, Tennessee) |
| ABSTRACT | Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/415999 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240208 | Sanjana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Zharko Daniloski (New York, New York) |
| ABSTRACT | Compositions and methods are provided for increasing the efficiency of precise gene editing of a target gene. One method includes administering to a mammalian subject in vivo or contacting mammalian cells ex vivo with a composition that temporarily inhibits, down-regulates, blocks or reduces the expression or activity of one or a combination of genes selected from Table 2 prior to or simultaneously with the components of a gene editing system. In one embodiment such components include a Cas enzyme and RNA guide for the precise editing repair of said target gene. In another embodiment such components include other DNA-targeting enzyme like TALE or ZFN for the precise editing repair of said target gene. Another method involves administering to a mammalian subject in vivo or contacting mammalian cells ex vivo with a composition that temporarily activates, up-regulates, stimulates or overexpresses the product, expression or activity of at least one or a combination of additional genes selected from Table 1 prior to or simultaneously with the components of a gene editing system for precise editing repair of said target gene, or any combination of inhibitors and activators. Still other methods include administering various combinations of such inhibiting and activating compositions. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563458 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240215 | Nair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil U. Nair (Medford, Massachusetts); Josef R. Bober (Medford, Massachusetts) |
| ABSTRACT | Disclosed are components and methods for preparing tagatose from galactose via isomerization reactions using engineered components. The engineered components include microbial cells and methods for preparing microbial cells that have been engineered to catalyze isomerization of galactose to tagatose, in which the microbial cells express cytoplasmically an exogenous L-arabinose isomerase enzyme. The disclosed microbial cells may further be modified for use in methods for preparing tagatose from galactose via isomerization reactions where the microbial cells are treated with reagents that permeabilize the cells. The disclosed methods enable isomerization reactions of galactose to tagatose at relatively high rates, high conversions, and elevated temperatures. |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/492264 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240226 | RAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghong RAO (Palo Alto, California); Jinghang XIE (Fremont, California); Ran MU (Stanford, California) |
| ABSTRACT | A dual-caged fluorogenic resorufin probe (CDA) has been developed that is stable under physiological condition with low background but becomes highly fluorescent upon β-lactamase/esterase activation and further oxidation. The probes of the disclosure are advantageous for initial screening of broad-spectrum β-lactam antibiotics resistance and carbapenem resistant pathogens at diagnosis. After a two-step filtration, the assay of the disclosure can report 103 c.f.u./mL cephalosporin- and carbapenem-resistant bacteria in urine within 2 hours at room temperature. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 18/550786 |
| CURRENT CPC | Heterocyclic Compounds C07D 265/38 (20130101) C07D 477/14 (20130101) C07D 501/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class C12Q 1/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) G01N 2333/986 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240232 | SEELIG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Georg SEELIG (Seattle, Washington); Alexander B. ROSENBERG (Seattle, Washington); Charles ROCO (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389890 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 2521/107 (20130101) C12Q 2525/161 (20130101) C12Q 2543/101 (20130101) C12Q 2563/179 (20130101) C12Q 2563/185 (20130101) C12Q 2565/514 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240233 | SEELIG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Georg SEELIG (Seattle, Washington); Alexander B. ROSENBERG (Seattle, Washington); Charles ROCO (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/389901 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 2521/107 (20130101) C12Q 2525/161 (20130101) C12Q 2543/101 (20130101) C12Q 2563/179 (20130101) C12Q 2563/185 (20130101) C12Q 2565/514 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240234 | Streets et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); CHAN ZUCKERBERG BIOHUB, INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Streets (Oakland, California); Nicolas Altemose (Oakland, California); Annie Maslan (Oakland, California); Aaron Straight (Stanford, California); Owen Smith (Stanford, California); Kousik Sundararajan (Stanford, Japan) |
| ABSTRACT | The present disclosure provides materials and methods for mapping specific protein-DNA interactions genome-wide, including highly repetitive areas of the genome, by performing targeted modifications of base-pairs at or near the genomic site where a protein of interest is interacting, followed by direct detection of those modified base-pairs using long-read DNA sequencing. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/564908 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240235 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellos of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of analyzing nucleic acids of a cell are provided. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/614970 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240237 | CAI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Long CAI (Pasadena, California); Chee Huat ENG (Pasadena, California); Lincoln OMBELETS (Pasadena, California) |
| ABSTRACT | Disclosed herein is a composition for linked amplification tethered with exponential radiance for signal amplification. Also disclosed herein, is a kit for linked amplification tethered with exponential radiance for signal amplification. Also disclosed herein, is a method linked amplification tethered with exponential radiance for signal amplification. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/563676 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240241 | Simms et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Simms (Ardsley, New York); Sayantan Bose (Collegeville, Pennsylvania); Jinzhou Yuan (Edgewater, New Jersey) |
| ABSTRACT | Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads. |
| FILED | Thursday, September 14, 2023 |
| APPL NO | 18/467510 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/0829 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6834 (20130101) Original (OR) Class C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240242 | Dhara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Surajit Dhara (Hanover, New Hampshire); Steven D. Leach (Hanover, New Hampshire); Sagar Chhangawala (New York, New York); Christina Leslie (New York, New York) |
| ABSTRACT | The present disclosure relates to an array-based assay for transposase-accessible chromatin and prognostic molecular markers of treatment-resistant/early recurrent cancer. The present disclosure also relates to predicting an outcome, such as duration of disease-free survival, in a cancer patient. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431569 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240262 | Khorosheva et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trace-Ability, Inc. (Van Nuys, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugenia Khorosheva (South Pasadena, California); Paolo Benigni (Los Angeles, California); Arkadij M. Elizarov (Woodland Hills, California) |
| ABSTRACT | A viable cell testing method, such as a sterility test, comprising the steps of obtaining a sample; conditioning the sample by maximizing viability of at least one RNA based biomarker, wherein the RNA based biomarker is preferably universal, abundant and short-lived; treating the sample to facilitate reagent contacting the RNA based biomarker; amplifying at least one nucleic acid sequence of the RNA based biomarker using amplification reagents; interacting with the amplified sequences of the RNA based biomarker to produce a readout signal; and detecting the readout signal and determining the presence of viable cells of the sample. A pharmaceutical protocol for a short-lived pharmaceutical implements the viable cell testing method, administering the pharmaceutical to the patient following safety confirmation and within three hours of obtaining the sample from the patient. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/395034 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240268 | Warrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Salus Discovery, LLC (Madison, Wisconsin); Flambeau Diagnostics, LLC (Monona, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Warrick (Madison, Wisconsin); Brianna Mullins (Deforest, Wisconsin); Patrick McMinn (Madison, Wisconsin); David Beebe (Monona, Wisconsin) |
| ABSTRACT | Provided herein are sample collection devices and methods of using the same for collecting a sample from a subject. In some aspects, provided herein are wearable sample collection devices. In some embodiments, provided herein are face masks containing a sample collection device and methods of using the same for collection and/or assessment of a sample. In some aspects, provided herein are sample collection devices and methods of using the same for detecting a pathogen in a sample collected from a subject. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 18/289354 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/097 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240272 | THORPE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Ryan K. THORPE (Iowa City, Iowa); Richard J.H. SMITH (Iowa City, Iowa); Hela AZAIEZ (Iowa City, Iowa) |
| ABSTRACT | In certain embodiments, the present invention provides the design of a targeted, amplicon-based massively parallel sequencing (MPS) panel focusing on amplifying specific regions of interest associated with genetic hearing loss and infectious diseases associated with hearing loss. The present invention also provides the design of a bioinformatics pipeline capable of performing automated analysis of regions of interest generated by the amplicon-based MPS panel, a targeted gene panel, exome sequencing, or genome sequencing. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/289316 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/705 (20130101) Original (OR) Class C12Q 1/6811 (20130101) C12Q 1/6874 (20130101) C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240359 | Narayan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alison R. H. Narayan (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed herein are methods for synthesizing or functionalizing organic compounds using a library of biocatalysts. The methods include separately admixing a reactant and an aqueous solvent with each biocatalyst in a library of biocatalysts to provide a library of product admixtures, wherein the admixing occurs under sustainable reaction conditions. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/268538 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 1/00 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241107 | SAINI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Neeraj SAINI (Sugarland, Texas); Chia-Chi CHANG (Houston, Texas); Johannes FAHRMANN (Houston, Texas); Robert R. JENQ (Houston, Texas); Samir HANASH (Houston, Texas); Sattva S. LAPU (Houston, Texas) |
| ABSTRACT | Disclosed herein are methods and compositions for determining and improving the likelihood of response and/or determining and decreasing the likelihood of toxicity to a cellular therapy using metabolomics. Embodiments of the disclosure include methods for measuring certain metabolites in biological samples of an individual for determining whether the individual has a responder or non-responder phenotype to the cellular therapy or to a toxicity of the cellular therapy. Embodiments also include compositions for increasing the response to a cellular therapy or decreasing toxicities associated with a cellular therapy. Embodiments also show that plasma metabolomics correlate with efficacy and toxicities associated with CAR-T therapy towards a cancer. The present disclosure relates to compositions and methods for predicting a subject's response to a CAR T-cell therapy, by analyzing the plasma metabolomics of the subject. The present disclosure further provides therapeutic compositions and methods for treating a subject having a cancer, to improve the efficacy of CAR T-cell therapy. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559329 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) A61K 31/132 (20130101) A61K 31/661 (20130101) A61K 35/17 (20130101) A61K 39/4631 (20230501) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241109 | Liu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haolin Liu (Denver, Colorado) |
| ABSTRACT | Disclosed herein are methods of restoring therapeutic antibody efficacy against a viral variant, of identifying wild-type specific memory B cells, cross-reactive memory B cells and mutation specific memory B cells in a subject following viral vaccination, and of monitoring a subject's memory B cell response against a vaccine antigen and/or a viral variant thereof. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405350 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) G01N 33/5091 (20130101) Original (OR) Class G01N 2333/11 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241118 | Rosen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antony Rosen (Pikesville, Maryland); Brittany Adler (Baltimore, Maryland); Livia A. Casciola-Rosen (Pikesville, Maryland) |
| ABSTRACT | Provided herein are methods of identifying a disease in a subject that include: (a) providing a biological sample from a subject; and (b) detecting an autoantibody that targets an antigen present in a telomerase/shelterin complex in the biological sample, thereby identifying a disease in the subject. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 18/289332 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2800/12 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241125 | EGLAND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristi A. EGLAND (Sioux Falls, South Dakota); Rick L. EVANS (Sioux Falls, South Dakota); James V. POTTALA (Sioux Falls, South Dakota) |
| ABSTRACT | Disclosed herein are compositions including reagents for detecting human autoantibodies against at least two proteins selected from the group consisting of A1AT, ANGPTL4, LRP10, GFRA1, LGALS3, CST2, DKK1, CAPC, GRP78, and GRN, wherein at least one of the antibody detection markers is selected from the group consisting of A1AT, LGALS3, and CAPC, and their use in monitoring efficacy of breast cancer therapy and breast cancer recurrence. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585815 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/54 (20130101) G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241132 | Greene et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark I. Greene (Penn Valley, Pennsylvania); Douglas B. Cines (Wynnewood, Pennsylvania); Zheng Cai (Wynnewood, Pennsylvania); Zhiqiang Zhu (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420177 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/522 (20130101) C07K 16/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/6863 (20130101) Original (OR) Class G01N 2333/522 (20130101) G01N 2400/40 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241138 | E. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | O'Bryant Sid E. (Aledo, Texas) |
| ABSTRACT | In one aspect, the present disclosure relates to a method for excluding a subject from the need for diagnostic testing for Parkinson's disease (PD). In another aspect, the present disclosure relates to a method for excluding a subject from recruitment into a clinical study for an investigational PD medication. In yet another aspect, the present disclosure relates to a method for screening a subject to determine whether the subject is ruled out as having PD, wherein the subjects who cannot be ruled out are administered a diagnostic test for PD, a treatment for PD, or a combination thereof. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559096 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/524 (20130101) G01N 2333/525 (20130101) G01N 2333/745 (20130101) G01N 2333/4713 (20130101) G01N 2333/4737 (20130101) G01N 2333/5409 (20130101) G01N 2333/5412 (20130101) G01N 2333/5418 (20130101) G01N 2333/5428 (20130101) G01N 2333/7151 (20130101) G01N 2333/70525 (20130101) G01N 2800/2835 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241141 | Gurkan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umut Gurkan (Shaker Heights, Ohio); Zoe Sekyonda (Cleveland, Ohio); Ozan Akkus (Cleveland, Ohio); Ran An (Shaker Heights, Ohio) |
| ABSTRACT | A method of determining at least one of hemoglobin oxygen affinity, rate of hemoglobin deoxygenation, or the presence of hemoglobin variants in blood of a subject, the method includes determining differences of absorption spectra of oxygenated and deoxygenated hemoglobin, red blood, and/or blood obtained from the subject and comparing the determined absorption spectra differences to a control value, wherein the absorption spectra differences are indicative of hemoglobin oxygen affinity, rate of hemoglobin deoxygenation, or the presence of hemoglobin variants in the blood of the subject. |
| FILED | Monday, May 23, 2022 |
| APPL NO | 18/563113 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/49 (20130101) G01N 33/721 (20130101) Original (OR) Class G01N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241201 | Park |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland) |
| ASSIGNEE(S) | The U.S.A, as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland) |
| INVENTOR(S) | Bu S. Park (Bethesda, Maryland) |
| ABSTRACT | A measurement volume is divided into multiple regions of interest (ROIs) and RF shimming parameters are independently selected for each of the ROIs. The ROIs have dimensions based on an RF wavelength in a specimen (i.e., based on RF frequency and specimen dielectric constant) and are selected to reduce wavelength-based nonuniformity in specimen excitation. For a multi-segment RF coil having segments situated about a cylindrical surface, ROI shapes include cylinders and cylindrical shells aligned along a coil axis. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/559316 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) Original (OR) Class G01R 33/5612 (20130101) G01R 33/5659 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241239 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lihong Wang (Arcadia, California); Yide Zhang (Pasadena, California) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of systems and methods of imaging using photoacoustic computed tomography through an ergodic relay having an integrated single-element ultrasonic transducer. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410842 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 8/4427 (20130101) A61B 8/4483 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52079 (20130101) Original (OR) Class G01S 15/8965 (20130101) G01S 15/8993 (20130101) Electric Machines Not Otherwise Provided for H02N 2/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242348 | Alizad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azra Alizad (Rochester, Minnesota); Mostafa Fatemi (Rochester, Minnesota); Rohit Nayak (Rochester, New York) |
| ABSTRACT | Described here are systems and methods for generating microvessel images from image data acquired with an ultrasound system while analyzing the image data in real-time, or retrospectively, to adaptively suppress noise in the data. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/563831 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242632 | Hackman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Hackman (Chapel Hill, North Carolina); Alex Murr (Chapel Hill, North Carolina); Richard Harry Feins (Chapel Hill, North Carolina) |
| ABSTRACT | A transoral robotic surgery (TORS) simulator system includes a three-dimensional human head model having an oral cavity made of a synthetic material. The oral cavity has a mandible structure and a simulated human tongue and/or a simulated human tonsil. The simulated human tongue and/or the simulated human tonsil are made from a silicone material. The simulator system also includes artificial tissue(s) attached within the oral cavity, the artificial tissue being formed to mimic a biological tissue, whether cancerous (e.g., a tumor) or otherwise. The simulator system also includes a marker material present on and/or within the artificial tissue; the marker material allows a user of the simulator system to visually differentiate between the artificial tissue and synthetic material of the oral cavity. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 18/282294 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/34 (20130101) Original (OR) Class G09B 23/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242807 | Minar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip Minar (Montgomery, Ohio); Alexander Vinks (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are methods for preparing a patient-specific vedolizumab dosing regimen for an individual in need thereof, comprising accessing, using a processor, a memory; selecting a first model stored in the memory; forecasting, based on the selected first model, a patient-specific predicted concentration time profile of the vedolizumab, selecting a dosing regimen, based on said forecasting, wherein said dosing regimen achieves a treatment objective, said treatment objective being a therapeutic level of vedolizumab; and outputting said dosing regimen. Further disclosed are methods of treating an individual having an inflammatory bowel disease. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413823 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242926 | Thorne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MiTeGen, LLC (Ithaca, New York) |
| ASSIGNEE(S) | MiTeGen, LLC (Ithaca, New York) |
| INVENTOR(S) | Robert Thorne (Ithaca, New York); Tyler Engstrom (Ithaca, New York); Richard Jayne (Lansing, New York) |
| ABSTRACT | Presented are sample-supporting foils and grids for cryo-electron microscopy (cryo-EM) systems, methods for making/using disclosed cryo-EM foils, grids, devices, and/or systems, and cryo-EM systems equipped with disclosed foils, grids, and/or devices. A sample-support grid assembly may include a grid body with opposing first and second grid surfaces and multiple grid holes extending through the grid body from the first grid surface to the second grid surface. A foil sheet is seated against the first surface and covers at least a subset of the grid holes in the grid body. The foil sheet includes multiple foil regions filled with foil holes and separated from each other by multiple elongated slots. These elongated slots enable the foil regions to move with respect to each other when the grid assembly is under load. The slots of the foil sheet may be arranged in an auxetic pattern. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/559750 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242955 | CLEMMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. CLEMMER (Bloomington, Indiana); Martin F. JARROLD (Bloomington, Indiana); Tarick J. EL-BABA (Bloomington, Indiana); Corinne A. LUTOMSKI (Bloomington, Indiana) |
| ABSTRACT | A method for analyzing charged particles may include generating, in or into an ion source region, charged particles from a sample of particles, causing the charged particles to enter a mass spectrometer from the ion source region at each of a plurality of differing physical and/or chemical conditions in a range of physical and/or chemical conditions in which the sample particles undergo structural changes, controlling the mass spectrometer to measure at least the charge magnitudes of the generated charged particles at each of the plurality of differing physical and/or chemical conditions, determining, with a processor, an average charge magnitude of the generated charged particles at each of the plurality of differing physical and/or chemical conditions based on the measured charge magnitudes, and determining, with the processor, an average charge magnitude profile over the range of physical and/or chemical conditions based on the determined average charge magnitudes. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436697 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0031 (20130101) H01J 49/165 (20130101) Original (OR) Class H01J 49/0468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243975 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Worcester, Massachusetts); Phillip Tai (Worcester, Massachusetts); Elisabet C. Mandon (Worcester, Massachusetts); Jianzhong Ai (Worcester, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432467 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 41/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240237948 | Hanson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy L. Hanson (San Francisco, California); Philip N. Sabes (San Francisco, California) |
| ABSTRACT | Methods are provided for the fabrication of microneedles. Microneedles fabricated according to the herein described methods will generally be constructed of multiple lengths of wire winded together, brazed and further manipulated to include a reversible engagement feature. The subject microneedles may find use in a variety of applications and, among other purposes, the reversible engagement feature of such a microneedle may by employed in implanting an implantable device into a biological tissue. Also provided are methods of inserting an implantable device into a biological tissue having an outer membrane. The subject methods may include ablating a section of the outer membrane and inserting the implantable device through the ablated section of outer membrane, including e.g., where the implantable device is inserted using a microneedle including e.g., those microneedles for which methods of fabrication are provided herein. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392987 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/685 (20130101) Original (OR) Class A61B 5/1459 (20130101) A61B 5/1473 (20130101) A61B 5/6868 (20130101) A61B 2562/12 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 41/0028 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0502 (20130101) A61N 1/0529 (20130101) A61N 1/0551 (20130101) A61N 5/0601 (20130101) A61N 2005/0612 (20130101) A61N 2005/0651 (20130101) Working or Processing of Metal Wire B21F 45/008 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0008 (20130101) B23K 2101/32 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240237991 | Burkart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Joseph Thomas Burkart (Bloomfield, Indiana); Danielle E. Cafasso (Southern Pines, North Carolina); Robert Henry Hayford (Colorado Springs, Colorado); Huckelberry Finne (Norfolk, Virginia); Jose Ramirez Vargas (Clovis, New Mexico); Michael P Abbott (Chesapeake, Virginia) |
| ABSTRACT | A junctional tourniquet apparatus and related methods of use. An exemplary tourniquet has an inverted cone shape, wherein a narrower end has a mushroom shaped base that is pressed against a compression target and a broader end has a plurality of pass-through slots for straps. Another exemplary tourniquet has a broad plate component and a handle component. The handle component has a mushroom shaped base on a first end and a handle on a second end. The handle component passes through the center of the plate component with threads that allow the handle component to compress a target by twisting the handle. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/430793 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1325 (20130101) Original (OR) Class A61B 17/1327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238118 | Eisenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David P. Eisenberg (Denver, Colorado); Robert James Copeland (Wheat Ridge, Colorado); Sara Locke (Golden, Colorado); Alexander Riffe (Broomfield, Colorado); Girish Srinivas (Broomfield, Colorado) |
| ABSTRACT | A cooling garment for use by workers in hot, humid climates comprising: a moisture-wicking under layer; an outer layer with an air permeability less than 200 L/m2/s when subjected to 125 Pascals of air pressure; at least one air channel formed between the layers and supported in at least some locations by a porous filler material; and an above ambient pressure gas supply attached operably to the inlet of the channel. Also a cooling garment comprising: a moisture-wicking under layer; an outer layer; one large air channel formed between the layers; tacks connecting the outer layer to the moisture-wicking under layer to prevent ballooning; and an above ambient pressure gas supply operably attached to the inlet of the channel. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413629 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/0025 (20130101) A41D 13/0053 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/02 (20130101) Original (OR) Class A61F 2007/006 (20130101) A61F 2007/0018 (20130101) A61F 2007/026 (20130101) A61F 2007/0067 (20130101) A61F 2007/0234 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238616 | VERHAAK |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roel VERHAAK (Farmington, Connecticut) |
| ABSTRACT | The invention relates, in part, to methods and compounds for radiosensitizing cells and increasing efficacy of treatments for cancers. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563207 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1001 (20130101) Original (OR) Class A61N 5/1077 (20130101) A61N 2005/1024 (20130101) A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238962 | O'Brien |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Courtney Jane O'Brien (San Antonio, Texas) |
| ABSTRACT | A tool box with vertically stacked monolithic trays. Each tray has pockets specifically shaped to receive complementary tools. The trays have upstanding cantilevered posts, which can space apart the superjacent tray. Alternatively, the posts can be received in complementary sockets of superjacent trays to prevent undue lateral movement while in the tool box. The post and socket geometry can be constructed to index the order in which trays are stacked and index how individual trays are oriented for optimal and sequenced access to the tools. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/418949 |
| CURRENT CPC | Workshop Equipment, e.g for Marking-out Work; Storage Means for Workshops B25H 3/06 (20130101) B25H 3/026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239455 | Ripplinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTLE SIGHT TECHNOLOGIES, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Ripplinger (Dayton, Ohio); David Charles Di Staulo (Dayton, Ohio); Sunny L. Kapka (Dayton, Ohio); Grant David Santo (Dayton, Ohio); Jay Phillip-Donald Vallie (Dayton, Ohio); Christopher J. Vogt (Dayton, Ohio); Colton A. Whitman (Dayton, Ohio) |
| ABSTRACT | An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A liquid-releasable vessel holding an illuminable dye located in the sealed internal region, along with an activator that is also located in the sealed internal region. When the liquid-releasable vessel releases the illuminable dye, the illuminable dye reacts with the activator, thereby resulting in illumination of the illuminable dye. The liquid-releasable vessel comprises an opening with a release mechanism (e.g., clamp, etc.). |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/581587 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 2201/04 (20130101) B63B 2201/22 (20130101) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/00 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 5/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239864 | Ishii et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kazusa Ishii (Bethesda, Maryland); Christian Hinrichs (Bethesda, Maryland) |
| ABSTRACT | Disclosed are isolated or purified T cell receptors (TCRs), wherein the TCRs have antigenic specificity for a CD22 amino acid sequence presented by a human leukocyte antigen (HLA) Class I molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 18/277521 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464413 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239960 | Epstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Eric Epstein (Pittsburgh, Pennsylvania); Cynthia Kutchko (Pittsburgh, Pennsylvania); Bret Boyle (Pittsburgh, Pennsylvania); Andrew Loughner (Pittsburgh, Pennsylvania) |
| ABSTRACT | Multiple cure coreactive compositions for three-dimensional printing include a polythiol, a reactive polyamine, and a coreactive compound that is reactive with both the polythiol and the reactive polyamine. The reaction between the polythiol and the coreactive compound is catalyzed by the reactive polyamine and has a gel time that is faster that the gel time of the reaction between the coreactive compound and reactive polyamine. Other examples of multiple cure coreactive compositions suitable for three-dimensional printing include a composition comprising a reactive polyamine, a polyfunctional Michael acceptor, a poly epoxide and a non-reactive catalyst; and a composition comprising a reactive polyamine, a polyfunctional Michael acceptor, a polyepoxide or combination thereof, and an amine reactive compound. The multiple cure coreactive compositions can have a fast gel time at a temperature of 25° C. that can be adjusted by changing the content of the reactive polyamine in the multiple cure coreactive composition. The multiple cure coreactive compositions are useful for three-dimensional printing. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 18/557314 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240150 | Skardal |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksander Skardal (Dublin, Ohio) |
| ABSTRACT | A method of making a cardiac construct is carried out by depositing a mixture comprising live mammalian cardiac cells (e.g., individual cells, organoids, or spheroids), fibrinogen, gelatin, and water on a support to form an intermediate cardiac construct; optionally co-depositing a structural support material (e.g., polycaprolactone) with the mixture in a configuration that supports the intermediate construct; and then contacting thrombin to the construct in an amount effective to cross-link the fibrinogen and produce a cardiac construct comprised of live cardiac cells that together spontaneously beat in a fibrin hydrogel. Constructs made and methods of using the same are also described. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538015 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 25/01 (20130101) C12M 29/00 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 5/067 (20130101) C12N 5/0657 (20130101) Original (OR) Class C12N 5/0671 (20130101) C12N 2501/999 (20130101) C12N 2502/14 (20130101) C12N 2502/1329 (20130101) C12N 2513/00 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/80 (20130101) C12N 2533/90 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240207 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); James Angstman (Charlestown, Massachusetts); Shengdar Tsai (Memphis, Tennessee) |
| ABSTRACT | Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/415999 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240208 | Sanjana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Zharko Daniloski (New York, New York) |
| ABSTRACT | Compositions and methods are provided for increasing the efficiency of precise gene editing of a target gene. One method includes administering to a mammalian subject in vivo or contacting mammalian cells ex vivo with a composition that temporarily inhibits, down-regulates, blocks or reduces the expression or activity of one or a combination of genes selected from Table 2 prior to or simultaneously with the components of a gene editing system. In one embodiment such components include a Cas enzyme and RNA guide for the precise editing repair of said target gene. In another embodiment such components include other DNA-targeting enzyme like TALE or ZFN for the precise editing repair of said target gene. Another method involves administering to a mammalian subject in vivo or contacting mammalian cells ex vivo with a composition that temporarily activates, up-regulates, stimulates or overexpresses the product, expression or activity of at least one or a combination of additional genes selected from Table 1 prior to or simultaneously with the components of a gene editing system for precise editing repair of said target gene, or any combination of inhibitors and activators. Still other methods include administering various combinations of such inhibiting and activating compositions. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563458 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240356 | Lisfi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdellah Lisfi (Baltimore, Maryland) |
| ABSTRACT | A cobalt ferrite film consisting of twinned cobalt ferrite isomer crystals, metastable normal Co2+tet[Fe3+oct]2O4 isomer [nCFO] and tetragonal inverted Fe3+tet[Co2+Fe3+]octO4 isomer [iCFO], the nCFO and iCFO isomer crystals alternating in chessboard fashion in three dimensions, the cobalt ferrite film made by pulsed laser deposition in a vacuum chamber from a polycrystalline CoFe2O4 target on a single crystal one-side polished MgO substrate preferably heated to a temperature of greater than about 600° C. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405155 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/002 (20130101) C30B 23/063 (20130101) C30B 29/26 (20130101) Original (OR) Class C30B 35/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241049 | Bak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Junhwi Bak (College Station, Texas); Yue Wu (Mission Viejo, California); Richard Bryant Miles (Bryan, Texas); Christopher M. Limbach (Ann Arbor, Michigan) |
| ABSTRACT | A system for measurement of light scattering from a test article includes a light emitting device, configured to emit a light beam onto the test article along light axis, a collection assembly configured to collect scattered light from the test article along a measurement axis that is oriented at a non-zero angle from the light axis, wherein the collection assembly includes a first angular spectral filter, and a second angular spectral filter spaced from the first angular spectral filter along the measurement axis, wherein a position or orientation of at least one of the first angular spectral filter and the second angular spectral is adjustable relative to the measurement axis. |
| FILED | Friday, August 11, 2023 |
| APPL NO | 18/233242 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/49 (20130101) Original (OR) Class G01N 2201/068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241256 | Crouch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California) |
| ASSIGNEE(S) | BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California) |
| INVENTOR(S) | Stephen C. Crouch (Mountain View, California); Trenton BERG (Mountain View, California); Randy R. REIBEL (Mountain View, California); James CURRY (Mountain View, California) |
| ABSTRACT | Techniques for Doppler correction of chirped optical range detection include obtaining a first set of ranges based on corresponding frequency differences between a return optical signal and a first chirped transmitted optical signal with an up chirp that increases frequency with time. A second set of ranges is obtained based on corresponding frequency differences between a return optical signal and a second chirped transmitted optical signal with a down chirp. A matrix of values for a cost function is determined, one value for each pair of ranges that includes one in the first set and one in the second set. A matched pair of one range in the first set and a corresponding one range in the second set is determined based on the matrix. A Doppler effect on range is determined based on combining the matched pair of ranges. A device is operated based on the Doppler effect. |
| FILED | Monday, September 18, 2023 |
| APPL NO | 18/469002 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/491 (20130101) G01S 7/493 (20130101) G01S 7/4911 (20130101) G01S 17/26 (20200101) G01S 17/34 (20200101) G01S 17/58 (20130101) Original (OR) Class G01S 17/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241288 | CAPASSO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Federico CAPASSO (Cambridge, Massachusetts); Antonio AMBROSIO (Arlington, Massachusetts); Noah A. RUBIN (Cambridge, Massachusetts); Robert C. DEVLIN (Cambridge, Massachusetts); Yao-Wei HUANG (Somerville, Massachusetts) |
| ABSTRACT | An optical device comprises a metasurface including a plurality of nanostructures. The nanostructures convert an input light of an arbitrary spin state into an output light of an arbitrary total angular momentum state characterized by a superposition of two independent orbital angular momentum (OAM) states. |
| FILED | Friday, September 14, 2018 |
| APPL NO | 16/647433 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241645 | Pawlowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Shruti Sharma (Beaverton, Oregon); Fabio Checconi (Fremont, California); Sriram Aananthakrishnan (Lubbock, Texas); Jesmin Jahan Tithi (San Jose, California); Jordi Wolfson-Pou (Santa Clara, California); Joshua B. Fryman (Corvallis, Oregon) |
| ABSTRACT | Systems, apparatuses and methods may provide for technology that includes a plurality of hash management buffers corresponding to a plurality of pipelines, wherein each hash management buffer in the plurality of hash management buffers is adjacent to a pipeline in the plurality of pipelines, and wherein a first hash management buffer is to issue one or more hash packets associated with one or more hash operations on a hash table. The technology may also include a plurality of hash engines corresponding to a plurality of dynamic random access memories (DRAMs), wherein each hash engine in the plurality of hash engines is adjacent to a DRAM in the plurality of DRAMs, and wherein one or more of the hash engines is to initialize a target memory destination associated with the hash table and conduct the one or more hash operations in response to the one or more hash packets. |
| FILED | Friday, March 29, 2024 |
| APPL NO | 18/621437 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0613 (20130101) Original (OR) Class G06F 3/0656 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242495 | Grace et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Michael Grace (Tucson, Arizona); Saikat Guha (Tucson, Arizona); Mark Neifeld (Tucson, Arizona); Amit Ashok (Tucson, Arizona) |
| ABSTRACT | Optical imaging includes: configuring a spatial mode sorter to provide, in response to a received input optical signal, a separate output optical signal for each spatial mode in a set of target spatial modes: receiving a set of output optical signals from the spatial mode sorter during a detection interval of time: processing information based at least in part on the set of output optical signals received in the detection interval of time: and providing an estimated measurement for discriminating among a first set of two or more predetermined target images based at least in part on information derived from the processing. During the detection interval of time, a total number of the output optical signals is greater than two and less than ten. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289382 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/60 (20220101) G06V 10/92 (20220101) Original (OR) Class G06V 10/764 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242618 | Osipychev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denis Osipychev (Huntsville, Alabama) |
| ABSTRACT | A computing system is configured to receive run-time position data for an intruder vehicle and run-time position data for an aircraft. A trajectory of the intruder vehicle is modeled based at least on the run-time position data for the intruder vehicle. A trajectory of the aircraft is modeled based at least on the run-time position data for the aircraft. The computing system is further configured to determine an intersection probability value that the trajectory of the intruder vehicle and the trajectory of the aircraft intersect. A behavior probability value that comprises a confidence level of a predicted behavior classification for the intruder vehicle is determined based at least on the run-time position data for the intruder vehicle and the run-time position data for the aircraft. Based at least on the intersection probability value and the behavior probability value, the computing system is configured to output a recommended collision avoidance action. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155659 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/044 (20230101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0021 (20130101) G08G 5/025 (20130101) G08G 5/045 (20130101) Original (OR) Class G08G 5/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242854 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayant Kumar (Boston, Massachusetts); Ramaswamy Nagarajan (Boston, Massachusetts); Siddhant Iyer (Boston, Massachusetts); Ravi Mosurkal (Boston, Massachusetts); Lian Li (Boston, Massachusetts); Claire Lepont (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is a curable composition with high optical transparency and good oxygen and moisture barrier properties, compositions for making the same, and methods of making and of using the same. |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/398599 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 9/08 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242950 | Glaros et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nasshville, Tennessee); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, WASHINGTON, DC (Washington, District of Columbia); TRIAD NATIONAL SECURITY, LLC (Los Almos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor C. Glaros (Albuquerque, New Mexico); Phillip Mach (Aberdeen Proving Ground, Maryland); Richard Caprioli (Brentwood, Tennessee); Jeremy Norris (Smyrna, Tennessee) |
| ABSTRACT | Systems and devices are disclosed to generate a multidimensional mass fingerprint that allows for identification on a low-resolution mass spectrometer equipped with post-ionization fragmentation. For this approach, rather than interrogating a sample that is processed into peptides using a single high resolution MS scan as in traditional fingerprinting, a raw unprocessed sample (containing all biochemical species: lipids, proteins, peptides, and metabolites) is analyzed by combining Matrix-Assisted Laser Dissociation/Ionization (MALDI) ionization with low resolution tandem mass spectrometry. The proposed system combines improvements in MS hardware and software with state-of-the-art machine learning (ML) approaches to usher in rapid biological detection. This technique does not require any prior separation (liquid or gas chromatography) and is therefore rapid (e.g. less than 5 sec) and amenable to high throughput (e.g. greater than 384 samples/hr). |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/285988 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 30/86 (20130101) G01N 30/88 (20130101) G01N 33/6851 (20130101) G01N 2030/8813 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242963 | Mi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zetian Mi (Ann Arbor, Michigan); Ping Wang (Ann Arbor, Michigan); Ding Wang (Ann Arbor, Michigan) |
| ABSTRACT | A method of fabricating a heterostructure includes providing a substrate, and implementing a non-sputtered, epitaxial growth procedure at a growth temperature to form a wurtzite structure supported by the substrate. The wurtzite structure includes an alloy of a III-nitride material. The non-sputtered, epitaxial growth procedure is configured to incorporate a group IIIB element into the alloy of the III-nitride material. The growth temperature is at a level such that the wurtzite structure exhibits a breakdown field strength greater than a ferroelectric coercive field strength of the wurtzite structure. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/559490 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) C30B 25/02 (20130101) C30B 29/403 (20130101) C30B 29/406 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0234 (20130101) H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/02175 (20130101) Original (OR) Class H01L 21/02266 (20130101) H01L 21/02271 (20130101) H01L 21/02337 (20130101) H01L 31/0735 (20130101) Electronic Memory Devices H10B 51/30 (20230201) H10B 53/30 (20230201) H10B 63/00 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243158 | Astratov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vasily Astratov (Charlotte, North Carolina); Grant Bidney (Charlotte, North Carolina); Igor Anisimov (Oakwood, Ohio); Joshua Duran (Dayton, Ohio); Gamini Ariyawansa (Dayton, Ohio) |
| ABSTRACT | A photodetector focal plane array (FPA) with enhanced detection capability and reduced thermal current is provided. The FPA includes light-concentrating dielectric structures in a form of arrays of elements with three-dimensional geometrical shapes. The elements have tapered sidewalls that taper inwardly toward a surface portion with a reduced width. A photodetector is joined to the portion with a reduced width. A metallic layer is disposed over the tapered sidewalls of the elements and the portion of the surface of the elements with a reduced width. The metallic layer provides mirror reflection properties to concentrate electromagnetic fields towards the detectors. The photodetector focal plane array may be used for infrared (IR) imaging applications in mid-wave IR (MWIR) and long-wave IR (LWIR) cameras as night vision and thermal imaging devices. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410080 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14625 (20130101) H01L 27/14649 (20130101) Original (OR) Class H01L 31/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243541 | Keyser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Keyser (Milton, Florida); Micah Raab (Crestview, Florida) |
| ABSTRACT | A fluid filled fiber for a quasi-phase matched generator and a laser incorporating such a fluid filled fiber. The laser has a liquid filled fiber with charge transfer molecules dissolved in a solvent. The liquid of the liquid filled fiber comprises or consists essentially of highly polar liquids and/or charge transfer molecules having relatively high molecular dipole values. |
| FILED | Tuesday, June 20, 2023 |
| APPL NO | 18/337713 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/361 (20130101) G02F 1/392 (20210101) G02F 1/395 (20130101) G02F 1/3534 (20130101) G02F 1/3548 (20210101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/20 (20130101) H01S 3/1083 (20130101) Original (OR) Class H01S 3/1086 (20130101) H01S 3/06729 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243810 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | The Boeing Company (Arlington, Virginia) |
| INVENTOR(S) | Yuanjian Xu (Thousand Oaks, California); James Franklin (Manhattan Beach, California); Brian K. Pheiffer (Palos Verdes Estates, California); Stephen G. Lambert (Maryland Heights, Missouri) |
| ABSTRACT | An optical high-power amplifier (“OPHA”) circuit, e.g., for a spaceborne satellite-based communication network, includes fiberoptic gain and polarization maintenance (“PM”) stages, a polarization splitter, first and second photodetectors, and an electronic control unit (“ECU”). The gain stage outputs an amplified optical signal in response to a low-power (“LP”) optical input signal. The PM stage outputs separate high and low power output signals in response to the amplified signal. A majority of power of the input signal is allocated to the HP output signal. The polarization splitter transmits the LP output signal along the slow and/or fast polarization axis. The photodetectors are arranged on the slow and fast axes. The ECU outputs a polarizer control signal to a polarization rotator device in response to electrical signals from one or both photodetectors to command the rotator device to output the LP optical input signal with a targeted polarized output state. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154491 |
| CURRENT CPC | Transmission H04B 7/18513 (20130101) H04B 7/18515 (20130101) H04B 10/118 (20130101) Original (OR) Class H04B 10/532 (20130101) Multiplex Communication H04J 14/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243975 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Worcester, Massachusetts); Phillip Tai (Worcester, Massachusetts); Elisabet C. Mandon (Worcester, Massachusetts); Jianzhong Ai (Worcester, Massachusetts) |
| ABSTRACT | In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432467 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 41/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240244354 | Ghobadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| INVENTOR(S) | Manya Ghobadi (Cambridge, Massachusetts); Zhizhen Zhong (Cambridge, Massachusetts); Weiyang Wang (Cambridge, Massachusetts); Liane Sarah Beland Bernstein (Cambridge, Massachusetts); Alexander Sludds (Cambridge, Massachusetts); Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | In-network Optical Inference (IOI) provides low-latency machine learning inference by leveraging programmable switches and optical matrix multiplication. IOI uses a transceiver module, called a Neuro Transceiver, with an optical processor to perform linear operations, such as matrix multiplication, in the optical domain. IOI's transceiver modules can be plugged into programmable packet switches, which are programmed to perform non-linear activations in the electronic domain and to respond to inference queries. Processing inference queries at the programmable packet switches inside the network, without sending them to cloud or edge inference servers, significantly reduces end-to-end inference latency experienced by users. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/561985 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Transmission H04B 10/524 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0039 (20130101) H04Q 2011/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240238769 | Florez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fernando Luis Esteban Florez (Moore, Oklahoma); Sharukh Soli Khajotia (Edmond, Oklahoma); Adam Justin Rondinone (Knoxville, Tennessee) |
| ABSTRACT | A dental composition comprising nitrogen-doped TiO2 nanoparticles, and a curable resin material, wherein the curable resin material comprises a polymer precursor component, and wherein the nitrogen-doped TiO2 NPs further comprise at least additional one dopant selected from the group consisting of Ag (silver), F (fluorine), P (phosphorus), and PO4 (phosphate). A method of using the dental composition in a dental application. The dental composition may be antibacterial in the absence of visible light or UV light. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394850 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/30 (20200101) A61K 6/62 (20200101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/75 (20130101) B01J 27/24 (20130101) Original (OR) Class B01J 31/06 (20130101) B01J 31/38 (20130101) B01J 35/39 (20240101) B01J 35/45 (20240101) B01J 37/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238771 | Sadow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron David Sadow (Ames, Iowa); Long Qi (Ames, Iowa); Yuting Li (Ames, Iowa); Uddhav Kanbur (Ames, Iowa); Scott Southern (Ames, Iowa); Frederic A. Perras (Ames, Iowa); Takeshi Kobayashi (Ames, Iowa) |
| ABSTRACT | The present application is directed to a supported rare earth-catalyst. This catalyst comprises a metal oxide support having Brønsted acid sites and a rare earth element-catalyst. The rare earth element-catalyst is bound to the Brønsted acid sites on the metal oxide support. The present application is also directed to methods of making supported rare earth-catalyst and methods for borylation of hydrocarbons using the supported rare earth-catalyst. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405475 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 29/088 (20130101) B01J 31/26 (20130101) B01J 31/2208 (20130101) Original (OR) Class B01J 31/2295 (20130101) B01J 37/0217 (20130101) B01J 37/0219 (20130101) B01J 37/0228 (20130101) B01J 2231/323 (20130101) B01J 2531/31 (20130101) B01J 2531/37 (20130101) B01J 2531/0205 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239004 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Rockville, Maryland); Xinpeng ZHAO (Berwyn Heights, Maryland); Yu LIU (Berwyn Heights, Maryland) |
| ABSTRACT | A piece of natural wood can be immersed in a first solution at a first temperature less than 100° C. and then immersed in a second solution at a second temperature greater than 100° C. so as to form a piece of partially-delignified wood. In some embodiments, the first and second solutions can be the same solution, and the immersion at the second temperature can be heating the solution from the first temperature to the second temperature. The immersion in the first and second solutions can be effective to remove 45-90% of lignin from the piece of natural wood and to destroy a structure of the ray cells in the piece of natural wood while retaining cell walls of the other cells. The partially-delignified wood can then be dried. After drying, the partially-delignified wood can be clastic along its tangential direction but inelastic along its radial and longitudinal directions. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/563562 |
| CURRENT CPC | Characteristic Features of Footwear; Parts of Footwear A43B 1/06 (20130101) Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/34 (20130101) B27K 3/0221 (20130101) B27K 5/06 (20130101) Original (OR) Class B27K 2240/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239042 | Saito et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomonori Saito (Oak Ridge, Tennessee); Amelia M. Elliott (Oak Ridge, Tennessee); Dustin B. Gilmer (Oak Ridge, Tennessee); Lu Han (Oak Ridge, Tennessee) |
| ABSTRACT | A method of binder jet additive manufacturing (BJAM) is provided. The method includes feeding a supply of powder particles to a powder bed, delivering an organic binder onto the powder bed in select locations of each layer to form a porous green part, and introducing to the binder a secondary component that chemically reacts with the binder to form a solid polymer matrix around the powder particles. The secondary component is introduced either by: (i) infiltration of the secondary component into the porous green part; or (ii) by combining the secondary component with the powder particles prior to feeding the powder particles to the powder bed. A binder system for BJAM is also provided. The binder system includes a reactive pair including an organic binder that is capable of being deposited on a powder bed; and a secondary component that is reactive with the organic binder. |
| FILED | Monday, July 17, 2023 |
| APPL NO | 18/222645 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/14 (20210101) B22F 2999/00 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239956 | RORRER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas A. RORRER (Golden, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Robin Marcelle CYWAR (Denver, Colorado); Robert David ALLEN (Golden, Colorado); Ryan William CLARKE (Wheat Ridge, Colorado); Gloria ROSETTO (Lakewood, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a first copolymer having a first repeat unit and a second repeat unit as defined by Structure (I) where |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529459 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/688 (20130101) C08G 63/698 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239981 | DONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao DONG (Lakewood, Colorado); Philip T. PIENKOS (Potsdam, New York) |
| ABSTRACT | The present disclosure relates to a method for making a non-isocyanate polyurethane (NIPU) foam, where the method includes decomposing a blowing agent having at least one of an amine carbamate salt and/or an amine bicarbonate salt to form a diamine and CO2 in the presence of a molecule comprising a plurality of cyclic carbonate functional groups and reacting the diamine with at least a portion of the cyclic carbonate functional groups to form the NIPU foam. In some embodiments of the present disclosure, the reacting and the decomposing may occur at substantially the same rate. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/484160 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 71/04 (20130101) C08G 2110/005 (20210101) C08G 2110/0058 (20210101) C08G 2110/0066 (20210101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/08 (20130101) Original (OR) Class C08J 2203/02 (20130101) C08J 2375/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240036 | PITCHUMANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ranga PITCHUMANI (Herndon,, Virginia); Ryan STODDARD (Radford, Virginia) |
| ABSTRACT | Solid-infused surfaces and articles having solid-infused surfaces are provided. The solid-infused surface includes (a) a substrate with a roughened surface having multi-scale surface roughness and a plurality of substrate asperities, and (b) a low surface-energy polymer coating a portion of the roughened surface forming the solid-infused surface having a fraction of the substrate asperities exposed on the solid-infused surface. The surfaces can be useful, in particular, for promoting condensation heat transfer performance. The articles and surfaces can include electronic components, optical components, or even pipes and other conduits for transporting certain fluids. Methods of making and methods of using the solid-infused surfaces are also provided. |
| FILED | Saturday, May 07, 2022 |
| APPL NO | 18/559525 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1681 (20130101) Original (OR) Class Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240196 | LONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Stephen P. LONG (Urbana, Illinois); Yu WANG (Urbana, Illinois); Kher Xing CHAN (Urbana, Illinois) |
| ABSTRACT | Aspects of the present disclosure relate to genetically altered plants with increased activity of one or more of a PPDK regulatory protein (PDRP), a Rubisco activase (Rea) protein, or a Rubisco protein that have increased photosynthetic efficiency under fluctuating light conditions. Further, aspects of the present disclosure relate to methods of producing and cultivating the genetically altered plants of the present disclosure. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563824 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/1294 (20130101) C12N 15/8213 (20130101) C12N 15/8269 (20130101) Original (OR) Class Enzymes C12Y 207/09001 (20130101) C12Y 401/01039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240331 | RIPPY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kerry Christine RIPPY (Golden, Colorado); Judith Cecilia VIDAL (Littleton, Colorado); Liam WITTEMAN (Golden, Colorado) |
| ABSTRACT | Methods and systems for removing impurities from molten salts using an electrochemical purification system having two electrodes. When a voltage is applied to the two-electrode electrochemical purification system, ions from a counter electrode may react with impurities in the molten salt to form materials which can deposit on the working electrode and out of the molten salt. The systems and methods may be more effective at removing impurities than traditional methods and produce less harmful byproducts. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/415807 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/20 (20130101) Original (OR) Class C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240587 | Moore et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeremy Fetvedt (Raleigh, North Carolina); Ian Cormier (Durham, North Carolina); Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Jeffrey Moore (Midlothian, Texas); Owen Pryor (San Antonio, Texas); Jeremy Fetvedt (Raleigh, North Carolina); Ian Cormier (Durham, North Carolina) |
| ABSTRACT | Presently disclosed is a power production plant that is operable to store and generate power. In a “charge mode” (when electricity price is low), an air separation unit (ASU) cools and liquefies ambient air into liquid oxygen (LOx), which is then stored in a storage vessel. In a “discharge mode” (when electrical price is high), the stored LOx is used by the power production plant to combust a fuel and form a combustion product stream that can be expanded in a turbine to generate power. The power production plant particularly can utilize carbon dioxide as a recycled, circulating or working fluid so that substantially all carbon dioxide produced in the power production can be captured. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/407518 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Original (OR) Class F02C 7/32 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240615 | Meyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pascal Meyer (Burnt Hills, New York); Biao Fang (Clifton Park, New York); Norman Arnold Turnquist (Carlisle, New York); Xiaopeng Li (Niskayuna, New York); Gregory Edward Cooper (Greenfield Center, New York); Christopher James Kenny (Schoharie, New York) |
| ABSTRACT | A tower structure particularly suited for a wind turbine includes a lower tower section formed of concrete and an upper tower section formed of steel. A transition system connects the upper tower section to the lower tower section, the transition system including a concrete component having a tubular wall with a base portion fixed on the lower tower section and a head portion connected to the upper tower section. The head portion extends radially outward beyond the upper tower section. A plurality of first tensioning tendons extend longitudinally at least partially through the tubular wall and are anchored to the concrete component at a top face of the head portion at locations radially outward of the upper tower section. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 18/015595 |
| CURRENT CPC | Wind Motors F03D 13/201 (20230801) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240885 | Cruz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Samuel Cruz (Cambridge, Massachusetts); Yajing Zhao (Cambridge, Massachusetts); Daniel Preston (Cambridge, Massachusetts); Kyle Wilke (Cambridge, Massachusetts); Evelyn Wang (Cambridge, Massachusetts) |
| ABSTRACT | Enhancing condensation heat transfer performance in applications including power generation, thermal management of high-performance electronics, water purification, distillation, natural gas processing, and air conditioning can be achieved with heat transfer devices. Condensation heat transfer can be enhanced via a hierarchical structure attached on a condenser surface. This novel hierarchical structure is composed of a thin, highly permeable, thermally conductive porous wick and a highly porous, robust, intrinsically hydrophobic membrane bonded or attached on top of the wick. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 18/561805 |
| CURRENT CPC | Steam or Vapour Condensers F28B 1/00 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/16 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/182 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241836 | Baronne |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Baronne (Allen, Texas) |
| ABSTRACT | Devices and techniques for parking threads in a barrel processor for managing cache eviction requests are described herein. A barrel processor includes eviction circuitry and is configured to perform operations to: (a) detect a thread that includes a memory access operation, the thread entering a memory request pipeline of the barrel processor; (b) determine that a data cache line has to be evicted from a data cache for the thread to perform the memory access operation; (c) copy the thread into a park queue; (d) evict a data cache line from the data cache; (e) identify an empty cycle in the memory request pipeline; (f) schedule the thread to execute during the empty cycle; and (g) remove the thread from the park queue. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/444148 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/126 (20130101) Original (OR) Class G06F 2212/1044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242950 | Glaros et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nasshville, Tennessee); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, WASHINGTON, DC (Washington, District of Columbia); TRIAD NATIONAL SECURITY, LLC (Los Almos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor C. Glaros (Albuquerque, New Mexico); Phillip Mach (Aberdeen Proving Ground, Maryland); Richard Caprioli (Brentwood, Tennessee); Jeremy Norris (Smyrna, Tennessee) |
| ABSTRACT | Systems and devices are disclosed to generate a multidimensional mass fingerprint that allows for identification on a low-resolution mass spectrometer equipped with post-ionization fragmentation. For this approach, rather than interrogating a sample that is processed into peptides using a single high resolution MS scan as in traditional fingerprinting, a raw unprocessed sample (containing all biochemical species: lipids, proteins, peptides, and metabolites) is analyzed by combining Matrix-Assisted Laser Dissociation/Ionization (MALDI) ionization with low resolution tandem mass spectrometry. The proposed system combines improvements in MS hardware and software with state-of-the-art machine learning (ML) approaches to usher in rapid biological detection. This technique does not require any prior separation (liquid or gas chromatography) and is therefore rapid (e.g. less than 5 sec) and amenable to high throughput (e.g. greater than 384 samples/hr). |
| FILED | Wednesday, April 06, 2022 |
| APPL NO | 18/285988 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 30/86 (20130101) G01N 30/88 (20130101) G01N 33/6851 (20130101) G01N 2030/8813 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243289 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Na Zhang (Allison Park, Pennsylvania); Qi Zheng (Allison Park, Pennsylvania); Bryann Ashleigh Morgan (Pittsburgh, Pennsylvania); Samuel Logan Esarey (Allison Park, Pennsylvania) |
| ABSTRACT | The present disclosure provides a binder comprising a fluoropolymer; an addition polymer comprising a silicon-containing functional group comprising at least one alkoxy substituent; and a liquid medium. The disclose also provides a slurry composition comprising the binder and an electrochemically active material and/or an electrically conductive agent. Also described herein are electrodes and electrical storage devices. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 18/560196 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/623 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243545 | PATRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susant K. PATRA (Brentwood, California); Robert J. DERI (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a thermoelectric cooling (TEC) embedded electronics system. In one embodiment the system has a substrate having a first surface and a second surface and constructed of a thermally and electrically conductive material, and a die. The die is configured to be supported from the first surface of the substrate and in thermal contact with the substrate. The die forms a heat generating component. A TEC material element is used which has a first surface and a second surface and is configured to be positioned at least partially against the second surface of the substrate. A heat pipe is provided which has a first portion and a second portion. The first portion is configured to be in thermal contact with the second surface of the TEC material, and the second portion is configured to sink heat generated by the die and transmitted through the substrate and the TEC material element. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/155503 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/38 (20130101) H01L 23/427 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/02415 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 10/80 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240244354 | Ghobadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| INVENTOR(S) | Manya Ghobadi (Cambridge, Massachusetts); Zhizhen Zhong (Cambridge, Massachusetts); Weiyang Wang (Cambridge, Massachusetts); Liane Sarah Beland Bernstein (Cambridge, Massachusetts); Alexander Sludds (Cambridge, Massachusetts); Ryan HAMERLY (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | In-network Optical Inference (IOI) provides low-latency machine learning inference by leveraging programmable switches and optical matrix multiplication. IOI uses a transceiver module, called a Neuro Transceiver, with an optical processor to perform linear operations, such as matrix multiplication, in the optical domain. IOI's transceiver modules can be plugged into programmable packet switches, which are programmed to perform non-linear activations in the electronic domain and to respond to inference queries. Processing inference queries at the programmable packet switches inside the network, without sending them to cloud or edge inference servers, significantly reduces end-to-end inference latency experienced by users. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 18/561985 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Transmission H04B 10/524 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0039 (20130101) H04Q 2011/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240238421 | PAYNE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); COLORADO SCHOOL OF MINES (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin A. PAYNE (Denver, Colorado); Melissa D. KREBS (Englewood, Colorado) |
| ABSTRACT | The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392543 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/16 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 47/22 (20130101) A61K 47/36 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 2300/62 (20130101) A61L 2300/256 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2300/416 (20130101) A61L 2430/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 16/22 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2305/04 (20130101) C08J 2305/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238476 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts) |
| ABSTRACT | A method of adhering wet tissues together includes providing a dry adhesive material that contains one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers. The method including the steps of placing the dry adhesive material in contact with one or more wet tissue surfaces; allowing the dry adhesive material to absorb liquid from the one or more wet surfaces to thereby swell the adhesive material; allowing instant crosslinking by intermolecular interactions between the adhesive material and the one or more wet surfaces; and allowing quick covalent crosslinking between the adhesive material and the one or more wet surfaces. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421735 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1102 (20130101) A61B 5/68335 (20170801) A61B 2562/0261 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2013/00676 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/7084 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0031 (20130101) Original (OR) Class A61L 24/043 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/02 (20130101) B32B 29/002 (20130101) B32B 2307/748 (20130101) B32B 2307/7163 (20130101) B32B 2405/00 (20130101) B32B 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238594 | Fried et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Itzhak FRIED (Los Angeles, California); Yuval NIR (Tel-Aviv, Israel); Maya GEVA-SAGIV (Los Angeles, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); RAMOT AT TEL AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296 Tel-Aviv 6139201 (IL) (Tel-Aviv, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Itzhak Fried (Los Angeles, California); Yuval Nir (Tel Aviv, Israel); Maya Geva-Sagiv (Oakland, California) |
| ABSTRACT | A closed-loop neuromodulatory system comprises one or more processors and memory. The system is configured to record signals from a first region of a brain of a human subject during sleep via a first electrode. The system is configured to determine, from the recorded signals, active periods of the first region. The system is configured to stimulate a second region of the brain, different from the first region, during the active periods via a second electrode that is electrically coupled to the first electrode via closed-loop control. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563692 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36064 (20130101) A61N 1/36092 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/36157 (20130101) A61N 1/36171 (20130101) A61N 1/36175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240238698 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingming Lu (Mason, Ohio) |
| ABSTRACT | A method of forming a yellow grease is provided. The method includes delivering a FOG lipid extraction agent into a processing tank. The method further includes preheating an FOG to a temperature of between 35° C. and 95° C. The method further includes mixing the preheated waste grease with the FOG lipid extraction agent in the processing tank to form the yellow grease. |
| FILED | Friday, January 26, 2024 |
| APPL NO | 18/423497 |
| CURRENT CPC | Separation B01D 11/0457 (20130101) Original (OR) Class B01D 11/0492 (20130101) B01D 2221/06 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 88/26 (20130101) Producing, e.g by Pressing Raw Materials or by Extraction From Waste Materials, Refining or Preserving Fats, Fatty Substances, e.g Lanolin, Fatty Oils or Waxes; Essential Oils; Perfumes C11B 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239021 | Nutt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Nutt (Irvine, California); Lessa Grunenfelder (Los Angeles, California); Timotei Centea (Venice, California); Mark Anders (Los Angeles, California); William Thomas Edwards (Fullerton, California); Sarah Grace Katz Schechter (Los Angeles, California) |
| ABSTRACT | Methods, apparatuses, and systems for making prepregs are disclosed. A method may include depositing a resin material onto a surface of a fiber bed and forming a number of discrete resin regions thereon. A distance between the resin regions may be measured to provide desired exposed portions of the surface to facilitate permeation of air through the exposed portions of the surface in a direction perpendicular to a plane of the fiber bed during a curing process of the prepreg. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383240 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 15/122 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/20 (20130101) B29C 70/443 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2307/04 (20130101) B29K 2309/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/24 (20130101) C08J 2361/10 (20130101) C08J 2363/00 (20130101) C08J 2375/04 (20130101) C08J 2379/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239666 | Leventis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| INVENTOR(S) | Nicholas Leventis (Rolla, Missouri); Chariklia Sotiriou-Leventis (Rolla, Missouri); Chakkaravarthy Chidambareswarapattar (Rolla, Missouri) |
| ABSTRACT | Porous three-dimensional networks of polyimide and porous three-dimensional networks of carbon and methods of their manufacture are described. For example, polyimide aerogels are prepared by mixing a dianhydride and a diisocyanate in a solvent comprising a pyrrolidone and acetonitrile at room temperature to form a sol-gel material and supercritically drying the sol-gel material to form the polyimide aerogel. Porous three-dimensional polyimide networks, such as polyimide aerogels, may also exhibit a fibrous morphology. Having a porous three-dimensional polyimide network undergo an additional step of pyrolysis may result in the three dimensional network being converted to a purely carbon skeleton, yielding a porous three-dimensional carbon network. The carbon network, having been derived from a fibrous polyimide network, may also exhibit a fibrous morphology. |
| FILED | Wednesday, August 23, 2023 |
| APPL NO | 18/454482 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/00 (20170801) C01B 32/30 (20170801) C01B 32/90 (20170801) Original (OR) Class C01B 32/97 (20170801) C01B 32/956 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/346 (20130101) C08G 18/3243 (20130101) C08G 18/7671 (20130101) C08G 73/1003 (20130101) C08G 73/1035 (20130101) C08G 73/1067 (20130101) C08G 2110/0091 (20210101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/28 (20130101) C08J 2201/0502 (20130101) C08J 2205/026 (20130101) C08J 2375/04 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/38 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239698 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Haizhou Liu (Irvine, California); Soyoon Kum (San Angelo, Texas); Xinyu Tang (Riverside, California) |
| ABSTRACT | Methods and systems for treating brackish desalination brine for the recovery of fresh water are disclosed. The method includes treating a source of brackish desalination brine with an ultraviolet-driven persulfate photolysis oxidation pre-treatment; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment to a chemical demineralization process; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment and with the chemical demineralization process to a microfiltration process; and treating the source of brackish desalination brine treated to the ultraviolet-driven persulfate photolysis oxidation pre-treatment, the chemical demineralization process, and the microfiltration process to a reverse osmosis treatment. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410694 |
| CURRENT CPC | Separation B01D 61/08 (20130101) B01D 61/16 (20130101) B01D 61/18 (20130101) B01D 61/025 (20130101) B01D 61/58 (20130101) B01D 61/147 (20130101) B01D 2311/04 (20130101) B01D 2311/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/441 (20130101) C02F 1/444 (20130101) C02F 1/722 (20130101) C02F 5/02 (20130101) C02F 9/00 (20130101) Original (OR) Class C02F 2201/32 (20130101) C02F 2305/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239854 | Czymmek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Donald Danforth Plant Science Center (ST. LOUIS, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirk Czymmek (St. Louis, Missouri); Dilip M. Shah (St. Louis, Missouri); Siva L.S. Velivelli (St. Louis, Missouri); Saurav Misra (St. Louis, Missouri); Hui Li (SuZhou, China PRC); Meenakshi Tetorya (St. Louis, Missouri) |
| ABSTRACT | Antimicrobial modified defensin or defensin-like peptides, modified C-terminal fragments of a defensin or defensin-like peptides and nucleic acids encoding the same are disclosed. Compositions comprising the defensin variant peptides and methods of their use to control microbial infections of plants and vertebrate subjects as well as contamination of feedstuffs and foodstuffs are also disclosed. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392130 |
| CURRENT CPC | Peptides C07K 14/4723 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/72 (20210501) C12R 2001/78 (20210501) C12R 2001/84 (20210501) C12R 2001/85 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239941 | Cai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Liheng Cai (Charlottesville, Virginia); Shifeng Nian (Charlottesville, Virginia); Jinchang Zhu (Charlottesville, Virginia) |
| ABSTRACT | Existing feedstock for additive manufacturing is mostly stiff, fragile plastics. We report a class of 3D printable, ultrasoft and stretchable elastomers by exploiting the self-assembly of responsive bottlebrush-based triblock copolymers. The microphase separation of the architecturally and chemically distinct blocks results in physically crosslinked networks that are stimuli-reversible, enabling their use for in-situ direct-write printing soft, elastic, and deformable 3D structures. The elastomers are 100% solvent-reprocessable yet thermostable within a wide range of temperature. Moreover, they exhibit an extensibility up to 600% and a Young's modulus low to ˜102 Pa, 106 times softer than plastics and more than 100 times softer than all existing 3D printable elastomers. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 18/018848 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 293/005 (20130101) Original (OR) Class C08F 2438/01 (20130101) Compositions of Macromolecular Compounds C08L 53/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239958 | FEIST et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | J. D. FEIST (Stanford, California); Yan XIA (Stanford, California) |
| ABSTRACT | A polymer is the reaction product of a substituted or unsubstituted 2,3-dihydrofuran, a substituted or unsubstituted 2,3-dihydropyran, or a mixture of any two or more thereof with a substituted or unsubstituted cycloalkenyl monomer, or a mixture of any two or more thereof, in the presence of a ring-opening metathesis catalyst. In some embodiments, the substituted or unsubstituted cycloalkenyl monomer is a substituted or unsubstituted norbornene monomer. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 18/553177 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/266 (20130101) Original (OR) Class C08G 65/2615 (20130101) C08G 65/2633 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/70 (20180101) C09D 171/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240216 | Mao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Chengde Mao (West Lafayette, Indiana); Victoria Elizabeth Paluzzi (Boise, Idaho); Cuizheng Zhang (West Lafayette, Indiana) |
| ABSTRACT | A splint single-stranded DNA (ssDNA), which comprises a linear splint sequence and a hairpin sequence on each side of the linear splint sequence; a splint ssDNA-ligating linear ssDNA monomeric complex; a method of producing a ssDNA circle; and a kit comprising the splint ssDNA and instructions for using the splint ssDNA to produce a ssDNA circle. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411891 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Enzymes C12Y 605/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240346 | Tao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Meng Tao (Fountain Hills, Arizona); Laidong Wang (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Tao (Fountain Hills, Arizona); Laidong Wang (Cupertino, California) |
| ABSTRACT | Methods for light-induced electroplating of aluminum are disclosed herein. Exemplary methods may comprise preparing an ionic liquid comprising aluminum chloride (AlCl3) and an organic halide, placing the silicon substrate into the ionic liquid, illuminating the silicon substrate, the illumination passing through the ionic liquid, and depositing aluminum onto the silicon substrate via a light-induced electroplating process, wherein the light-induced electroplating process utilizes an applied current that does not exceed a photo-generated current generated by the illumination. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/586085 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/54 (20130101) C25D 3/665 (20130101) Original (OR) Class C25D 5/10 (20130101) C25D 5/011 (20200801) C25D 5/50 (20130101) C25D 7/12 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/068 (20130101) H01L 31/0682 (20130101) H01L 31/1804 (20130101) H01L 31/022425 (20130101) H01L 31/022458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240356 | Lisfi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdellah Lisfi (Baltimore, Maryland) |
| ABSTRACT | A cobalt ferrite film consisting of twinned cobalt ferrite isomer crystals, metastable normal Co2+tet[Fe3+oct]2O4 isomer [nCFO] and tetragonal inverted Fe3+tet[Co2+Fe3+]octO4 isomer [iCFO], the nCFO and iCFO isomer crystals alternating in chessboard fashion in three dimensions, the cobalt ferrite film made by pulsed laser deposition in a vacuum chamber from a polycrystalline CoFe2O4 target on a single crystal one-side polished MgO substrate preferably heated to a temperature of greater than about 600° C. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405155 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/002 (20130101) C30B 23/063 (20130101) C30B 29/26 (20130101) Original (OR) Class C30B 35/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240241115 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chen Yu CHEN (College Park, Maryland); UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chen Yu CHEN (College Park, Maryland); William E. BENTLEY (Annapolis, Maryland); Dana MOTABAR (Darnestown, Maryland); Jinyang LI (Pasadena, California); Sally Patricia WANG (Greenbelt, Maryland); Chen-Yu TSAO (Potomac, Maryland); Gregory F. PAYNE (Hunt Valley, Maryland) |
| ABSTRACT | The present disclosure provides sensors, devices, systems and methods for detecting an analyte in a sample using electrochemical readouts. The sensors are electroassembled with abiological recognition element and are capable of specifically binding to analytes within a sample. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/554409 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) G01N 33/5438 (20130101) Original (OR) Class G01N 33/6854 (20130101) G01N 2333/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242913 | Hines et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa A. Hines (Ithaca, New York); William J.I. De Benedetti (Ithaca, Indiana) |
| ABSTRACT | A method of forming a multi-layer structure comprising may include a step of providing a substrate, a step of depositing a protection layer, a step of depositing a thin film material, and a step of detaching. The substrate may have a low surface energy surface or a low surface energy coating or modification disposed on at least a portion of a substrate to form a low surface energy surface. The step of depositing a protection layer may be performed on at least a portion of the low surface energy surface. The step of detaching may detach the multi-layer structure from the substrate |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559491 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) Original (OR) Class H01J 2201/3423 (20130101) H01J 2209/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242953 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Brett M. Marsh (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for focusing ions using counter flows of opposite or like charged ions. In certain embodiments, oppositely charged ions are introduced in a counter flow to a target ion beam within an atmospheric ion guide. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563569 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/16 (20130101) H01J 49/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243356 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DREXEL UNIVERSITY (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (PHILADELPHIA, Pennsylvania) |
| INVENTOR(S) | Xiaowei Li (Philadelphia, Pennsylvania); Yongwei Zheng (Philadelphia, Pennsylvania); Christopher Li (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Ionic liquid N-methyl-N-propyl-pyrrolidinium bis(fluorosulfonyl)imide (Pyr13FSI) was introduced into a hybrid network to obtain a series of gel polymer electrolytes (GPEs). Mechanical and electrochemical properties of the GPEs were tuned through controlling the network structure and ionic liquid contents, and ionic conductivity higher than 1 mS cm−1 at room temperature was achieved. The newly developed GPEs are flame-retardant and show excellent thermal and electrochemical stability as well as ultra-stability with lithium metal anode. Symmetrical lithium cells with the GPEs exhibit a stable cycling over 6800 h at a current density of 0.1 mA cm−2 and stable lithium stripping-plating at 1 mA cm−2, the highest current density reported for ionic liquid-based GPEs. Moreover, Li/LiFePO4 batteries with the obtained GPEs exhibit desirable cycling stability and rate performance over a wide temperature range from 0° C. to 90° C. |
| FILED | Wednesday, November 08, 2023 |
| APPL NO | 18/504291 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/336 (20130101) C08G 77/045 (20130101) C08G 2220/00 (20130101) C08G 2650/20 (20130101) C08G 2650/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 10/0567 (20130101) H01M 10/4235 (20130101) H01M 2004/027 (20130101) H01M 2300/0025 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240237959 | Yeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (oAKLAND, California); THE UNITED STTES GOVERNMENT AS REPRESENTED BY TH E DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin M. Yeh (Hillsborough, California); Yanjun Fu (San Francisco, California) |
| ABSTRACT | The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the encapsulated gas or partial vacuum particle contrast material into the bowel lumen with or without the delivery of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434667 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/03 (20130101) A61B 6/032 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/484 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/50 (20130101) A61K 49/0419 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240239913 | SCANZELLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); OKLAHOMA MEDICAL RESEARCH FOUNDATION (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CARLA R. SCANZELLO (Philadelphia, Pennsylvania); TIMOTHY GRIFFIN (Oklahoma City, Oklahoma) |
| ABSTRACT | Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/411242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 14/7455 (20130101) C07K 16/2896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Enzymes C12Y 207/12002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240240173 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William H. Robinson (Stanford, California); Yann Chong Tan (Stanford, California); Jeremy Sokolove (Stanford, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529287 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242344 | Madabhushi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); The United States Government as Represented by The Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Shayan Monabbati (Cleveland, Ohio); Kaustav Bera (Cleveland, Ohio) |
| ABSTRACT | The present disclosure, in some embodiments, relates to a method. The method includes accessing one or more digitized pathology images of a cell cluster area comprising epithelial cells obtained from a bile duct of a patient having a bile duct stricture. The cell cluster area is segmented to identify segmented nuclei and non-nuclei regions. A plurality of texture features are extracted from the segmented nuclei and the non-nuclei regions. A plurality of nuclear shape features are extracted from the segmented nuclei. The plurality of nuclear shape features and the plurality of texture features are provided to a machine learning model configured to generate a cytological diagnosis of the epithelial cells within the cell cluster area. |
| FILED | Wednesday, September 13, 2023 |
| APPL NO | 18/466032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/02 (20130101) A61B 2010/0216 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/40 (20130101) G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240242834 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yixiang DENG (Washington, District of Columbia); George KARNIADAKIS (Providence, Rhode Island); Lu LU (Providence, Rhode Island); Christos MANTZOROS (Washington, District of Columbia); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yixiang Deng (Washington, District of Columbia); George Kamiadakis (Providence, Rhode Island); Lu Lu (Providence, Rhode Island); Christos Mantzoros (Providence, Rhode Island) |
| ABSTRACT | Described herein are methods and systems for preventing a glycemic event. One or more improved deep-learning models for predicting glycemic events may receive current blood glucose data and other physiological data from associated with a patient. The one or more models may determine one or more future blood glucose values and whether or not the one or more future blood glucose values satisfy one ore more thresholds associated with one or more glycemic events (e.g., hypoglycemia and/or hyperglycemia). If the one or more future blood glucose values satisfy the one or more thresholds, one or more actions may be taken (e.g., administration of insulin). |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 18/289499 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7275 (20130101) A61B 5/14532 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240243369 | Elliott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian J. Elliott (Superior, Colorado); Vinh T. Nguyen (Arvada, Colorado); Rhia M. Martin (Arvada, Colorado); Joseph Reinicke (Lakewood, Colorado) |
| ABSTRACT | A battery with a lithium metal anode, a separator; a nickel metal oxide cathode, a lithium salt, a first solvent, having a low melting point, a second solvent having a high electrochemical stability, The battery has a charge transfer-assisting polymer coating that coats a liquid electrolyte-solid cathode interfacial surface of the nickel metal-oxide cathode. Alternatively, the battery has a charge transfer-assisting polymer coating that coats that coats a liquid electrolyte-solid cathode interfacial surface of the lithium metal anode. The battery has enhanced discharge specific energy at −40 to −60° C. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531673 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/623 (20130101) H01M 10/052 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 50/383 (20210101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240243567 | Ewanchuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Jeffrey Ewanchuk (Manchester, Connecticut); Baljit Riar (Rocky Hill, Connecticut); Xin Wu (Glastonbury, Connecticut) |
| ABSTRACT | A method of open-loop fault control of a solid state circuit breaker includes the steps of populating a lookup table with predetermined current and temperature values and corresponding interrupt times, measuring a temperature of the solid state circuit breaker, measuring an electrical current passing through the solid state circuit breaker, estimating interrupt time from the lookup table based on the measured temperature and current values, determining to initiate a shutoff of the solid state circuit breaker based on the estimated interrupt time, and initiating a shutoff process of the solid state circuit breaker. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097124 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 3/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240237629 | Davidowitz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goggy Davidowitz (Tucson, Arizona) |
| ABSTRACT | A grasshopper harvesting system for collecting grasshoppers featuring a vehicle, a collection array, a transfer mechanism, and a storage container or shredder. The system can be attached to an existing vehicle such as a tractor, ATV, truck, or a GPS-controlled autonomous vehicle that can be programmed to collect grasshoppers according to a particular desired route of a particular field, to protect crops or for consumption purposes. Further, the system may feature a detachable bin that empties the grasshoppers when the bin is full. The system may collect grasshopper pests in organic fields, reduce locust swarm densities in breeding grounds, and harvest grasshoppers from rangeland. The grasshoppers may either be destroyed or processed as edible insects for food and feed. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/557472 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 5/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240241115 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chen Yu CHEN (College Park, Maryland); UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chen Yu CHEN (College Park, Maryland); William E. BENTLEY (Annapolis, Maryland); Dana MOTABAR (Darnestown, Maryland); Jinyang LI (Pasadena, California); Sally Patricia WANG (Greenbelt, Maryland); Chen-Yu TSAO (Potomac, Maryland); Gregory F. PAYNE (Hunt Valley, Maryland) |
| ABSTRACT | The present disclosure provides sensors, devices, systems and methods for detecting an analyte in a sample using electrochemical readouts. The sensors are electroassembled with abiological recognition element and are capable of specifically binding to analytes within a sample. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 18/554409 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/126 (20130101) G01N 33/5438 (20130101) Original (OR) Class G01N 33/6854 (20130101) G01N 2333/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20240239698 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Haizhou Liu (Irvine, California); Soyoon Kum (San Angelo, Texas); Xinyu Tang (Riverside, California) |
| ABSTRACT | Methods and systems for treating brackish desalination brine for the recovery of fresh water are disclosed. The method includes treating a source of brackish desalination brine with an ultraviolet-driven persulfate photolysis oxidation pre-treatment; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment to a chemical demineralization process; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment and with the chemical demineralization process to a microfiltration process; and treating the source of brackish desalination brine treated to the ultraviolet-driven persulfate photolysis oxidation pre-treatment, the chemical demineralization process, and the microfiltration process to a reverse osmosis treatment. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410694 |
| CURRENT CPC | Separation B01D 61/08 (20130101) B01D 61/16 (20130101) B01D 61/18 (20130101) B01D 61/025 (20130101) B01D 61/58 (20130101) B01D 61/147 (20130101) B01D 2311/04 (20130101) B01D 2311/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/441 (20130101) C02F 1/444 (20130101) C02F 1/722 (20130101) C02F 5/02 (20130101) C02F 9/00 (20130101) Original (OR) Class C02F 2201/32 (20130101) C02F 2305/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240241100 | Hill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ITA International, LLC (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Cary Hill (Blacksburg, Virginia); Matthew Scott Hull (Dublin, Virginia) |
| ABSTRACT | Methods, apparatuses, and kits for detection of substances in water by forming a complex with an indicator reagent and filtering the complex on a filter or membrane are described. The concentrated indicator on the filter, membrane or other capture device provides a colorimetric readout that can determine the amount of substance present in a water sample. A computer-implemented method for determining the concentration of substances in water based on color data from the colorimetric readout is also described. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/617129 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 21/82 (20130101) G01N 31/02 (20130101) G01N 31/22 (20130101) G01N 33/182 (20130101) G01N 33/1813 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240241645 | Pawlowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Pawlowski (Beaverton, Oregon); Shruti Sharma (Beaverton, Oregon); Fabio Checconi (Fremont, California); Sriram Aananthakrishnan (Lubbock, Texas); Jesmin Jahan Tithi (San Jose, California); Jordi Wolfson-Pou (Santa Clara, California); Joshua B. Fryman (Corvallis, Oregon) |
| ABSTRACT | Systems, apparatuses and methods may provide for technology that includes a plurality of hash management buffers corresponding to a plurality of pipelines, wherein each hash management buffer in the plurality of hash management buffers is adjacent to a pipeline in the plurality of pipelines, and wherein a first hash management buffer is to issue one or more hash packets associated with one or more hash operations on a hash table. The technology may also include a plurality of hash engines corresponding to a plurality of dynamic random access memories (DRAMs), wherein each hash engine in the plurality of hash engines is adjacent to a DRAM in the plurality of DRAMs, and wherein one or more of the hash engines is to initialize a target memory destination associated with the hash table and conduct the one or more hash operations in response to the one or more hash packets. |
| FILED | Friday, March 29, 2024 |
| APPL NO | 18/621437 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0613 (20130101) Original (OR) Class G06F 3/0656 (20130101) G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240243369 | Elliott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian J. Elliott (Superior, Colorado); Vinh T. Nguyen (Arvada, Colorado); Rhia M. Martin (Arvada, Colorado); Joseph Reinicke (Lakewood, Colorado) |
| ABSTRACT | A battery with a lithium metal anode, a separator; a nickel metal oxide cathode, a lithium salt, a first solvent, having a low melting point, a second solvent having a high electrochemical stability, The battery has a charge transfer-assisting polymer coating that coats a liquid electrolyte-solid cathode interfacial surface of the nickel metal-oxide cathode. Alternatively, the battery has a charge transfer-assisting polymer coating that coats that coats a liquid electrolyte-solid cathode interfacial surface of the lithium metal anode. The battery has enhanced discharge specific energy at −40 to −60° C. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531673 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/623 (20130101) H01M 10/052 (20130101) H01M 10/0567 (20130101) H01M 10/0569 (20130101) H01M 10/4235 (20130101) Original (OR) Class H01M 50/383 (20210101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
20240242250 — SYSTEM AND METHODS FOR CREATING A DISTRIBUTION CAMPAIGN AND ASSOCIATED DIGITAL CONTENT
| US 20240242250 | Mello et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fernando Mello (Washington, District of Columbia); Robert E. Dixon, JR. (Haymarket, Virginia) |
| ABSTRACT | Systems and methods for creating a distribution campaign and delivering a digital content associated with the distribution campaign are disclosed herein. In some embodiments, an imaging device may capture an image of one or more campaign distribution items. A user interface in communication with the image capture device may receive a request to generate a distribution campaign, receive target addresses, and receive digital content associated with the distribution campaign. The user interface may generate an intelligent campaign barcode for each of the target addresses and a label for each of the target addresses to be affixed to one or more campaign distribution items. The user interface may receive the image of a campaign distribution item, detect the intelligent campaign barcode on the label affixed to the campaign distribution item; and deliver the digital content to an email address associated with the target address based on the intelligent campaign barcode. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410730 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0276 (20130101) Original (OR) Class G06Q 30/0277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240241162 | IMHOF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ERIC A. IMHOF (Albuquerque, New Mexico); STEVEN RYAN JEFFERTS (Chatsworth, California) |
| ABSTRACT | One example includes an electrometer system. The system includes a sensor cell comprising alkali metal atoms within, and an optical beam system configured to provide at least one optical beam through the sensor cell to provide a first Rydberg energy state of the alkali metal atoms, the at least one optical beam exiting the sensor cell as a detection beam. The system also includes a radio frequency (RF) tuning field generator configured to generate an RF tuning signal having a tuning frequency that is equal to an energy difference between the first Rydberg energy state and a second Rydberg energy state of the alkali metal atoms. The system further includes a detection system configured to monitor the detection beam to detect an external signal having a frequency that is between the first and second Rydberg energy states. |
| FILED | Monday, July 24, 2023 |
| APPL NO | 18/357867 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/14 (20130101) G01R 29/0885 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 18, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240718.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page