FedInvent™ Patent Applications
Application Details for Thursday, July 25, 2024
This page was updated on Saturday, July 27, 2024 at 02:27 AM GMT
Department of Health and Human Services (HHS)
| US 20240245301 | GODAVARTY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Anuradha GODAVARTY (Miami, Florida); Kevin LEIVA (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Anuradha GODAVARTY (Miami, Florida); Kevin LEIVA (Miami, Florida) |
| ABSTRACT | Systems and methods for imaging breath-hold (BH)-induced oxygenation changes in a patient are provided. A non-invasive, non-contact device can be used to image BH-induced oxygenation changes in one or more parts (e.g., foot) of a patient. The patient can hold his or her breath for a set amount of time while imaging is performed using the device, and the imaging can be performed before and/or after the time while the patient is holding his or her breath as well (e.g., during a recovery period). This enables tissue oxygenation based flow correlation independent of melanin concentration (e.g., skin color) of the patient and/or the curvature of the tissue (of the patient) being imaged. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417405 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/083 (20130101) A61B 5/0086 (20130101) Original (OR) Class A61B 5/445 (20130101) A61B 5/742 (20130101) A61B 2576/00 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245312 | SRINIVASAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mandayam A. SRINIVASAN (Newton, Massachusetts); Mohan Thanikachalam (Boston, Massachusetts); Edward Howard Adelson (Winchester, Massachusetts); Abhijit Biswas (Shyamnagar, India) |
| ABSTRACT | A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters. |
| FILED | Wednesday, March 13, 2024 |
| APPL NO | 18/604009 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1075 (20130101) A61B 5/1079 (20130101) A61B 5/02007 (20130101) A61B 5/02233 (20130101) Original (OR) Class A61B 8/0891 (20130101) A61B 2560/0223 (20130101) A61B 2562/04 (20130101) A61B 2562/0214 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245512 | Padala et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sai Muralidhar Padala (Atlanta, Georgia); Eric Leo Sarin (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and/or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge. |
| FILED | Friday, March 22, 2024 |
| APPL NO | 18/614081 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/246 (20130101) A61F 2/2463 (20130101) Original (OR) Class A61F 2/2466 (20130101) A61F 2220/0016 (20130101) A61F 2250/0098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245614 | LANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Frederick F. LANG (Houston, Texas); Elizabeth J. SHPALL (Houston, Texas); Katy REZVANI (Houston, Texas); Mayela MENDT (Houston, Texas); Daniel LEDBETTER (Houston, Texas); Joy GUMIN (Houston, Texas); Brittany PARKER KERRIGAN (Houston, Texas); Anwar HOSSAIN (Houston, Texas); Frederick M. LANG (Houston, Texas) |
| ABSTRACT | Aspects of the disclosure encompass systems, methods, and compositions for producing exosomes from mesenchymal stem cells and, optionally, loading said exosomes with one or more therapeutic agents. The systems, methods, and compositions may occur in an automated cell expansion system that allows for controllable parameters and from which cells and exosomes may be harvested at one or more times as part of a particular regimen. The exosomes may be loaded with one or more therapeutic agents using electroporation. In specific aspects, the exosomes may be provided to an individual in need thereof, including in some cases where the individual in need thereof is an individual having a medical disorder for which the exosomes would be therapeutic. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 18/559667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 9/5068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0665 (20130101) C12N 15/1135 (20130101) C12N 15/1138 (20130101) C12N 2310/141 (20130101) C12N 2501/65 (20130101) C12N 2510/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245618 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Thursday, August 03, 2023 |
| APPL NO | 18/365187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/553 (20130101) A61K 9/51 (20130101) A61K 9/127 (20130101) A61K 9/1271 (20130101) A61K 9/1272 (20130101) A61K 9/5123 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 38/465 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245620 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245627 | Straub et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Adam C. Straub (Pittsburgh, Pennsylvania); Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco J. Schopfer (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are new pharmacological therapies that increase CYB5R3 activity, improve vascular function and limit inflammation by restoring the redox balance in CVD. In one embodiment, disclosed herein are compounds that include an alkyl chain containing a nitroalkene group conjugated to a quinone-containing moiety. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/282099 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 205/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245633 | Griffin et al. |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Griffin (Jupiter, Florida); Theodore Kamenecka (Palm Beach Gardens, Florida); Mi Ra Chang (Jupiter, Florida); Christelle Doebelin (Jupiter, Florida) |
| ABSTRACT | The T cell specific RORgamma isoform RORgammat has been shown to be the key lineage-defining transcription factor to initiate the differentiation program of TH17 and TC17 cells, cells that have demonstrated anti-tumor efficacy, RORgammat controls gene networks that enhance immunity including increased IL17 production and decreased immune suppression. Agonists of RORgammat have been shown to increase the basal activity of RORgammat enhancing TH17 cell proliferation. Here we show that activation of RORgammat using synthetic agonists drives proliferation of cells while decreasing levels of the immune checkpoint protein PD-1, a mechanism that should enhance anti-tumor immunity while blunting tumor associated adaptive immune resistance. Interestingly, putative endogenous agonists drive proliferation of TH17 cells but do not repress PD-1. These findings suggest that synthetic agonists of RORgammat should activate TC17/TH17 cells, decrease the population of Tregs, repress PD-1, and produce IL17 in situ, an immune factor associated with good prognosis in cancer. |
| FILED | Tuesday, November 01, 2016 |
| APPL NO | 15/768888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/137 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 31/192 (20130101) A61K 31/277 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/4402 (20130101) A61K 31/4406 (20130101) A61K 31/4409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245639 | Dolivo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Michael Dolivo (Evanston, Illinois); Adrian E. Rodrigues (Evanston, Illinois); Seok Jong Hong (Evanston, Illinois); Thomas A. Mustoe (Evanston, Illinois); Robert D. Galiano (Evanston, Illinois) |
| ABSTRACT | Disclosed are compounds, compositions and methods for antagonizing fibroblast activation. Particularly disclosed are compounds, methods and compositions for treating and/or preventing scar formation with a retinoid. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/203 (20130101) Original (OR) Class A61K 31/4535 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245661 | Kapitsinou et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Pinelopi Kapitsinou (Evanston, Illinois); Ratnakar Tiwari (Evanston, Illinois) |
| ABSTRACT | Disclosed are agents, compositions, and methods for treating acute kidney injury (AKI). Particularly disclosed are agents, compositions, and methods for treating AKI and reducing the progression from AKI to chronic kidney disease by administering an agent that inhibits or reduces expression of monocarboxylate transporter 4 (MCT4). |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420725 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245696 | Burdine et al. |
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| FUNDED BY |
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| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas); Arkansas Children's Research institute (Little Rock, Arkansas) |
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| INVENTOR(S) | Lyle Burdine (Little Rock, Arkansas); Marie Burdine (Little Rock, Arkansas); Ara Kim Wiese (Little Rock, Arkansas) |
| ABSTRACT | The present disclosure relates to compositions and methods for improving the transplantation outcome and/or reducing immune response in a subject. The compositions comprise a DNA-PK inhibitor. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245702 | Edge et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Edge (Brookline, Massachusetts); Niliksha Gunewardene (Boston, Massachusetts) |
| ABSTRACT | Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 31/137 (20130101) A61K 31/506 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245703 | TRAVERS |
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| APPLICANT(S) | Wright State University (Dayton, Ohio); TheUnited States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey B. TRAVERS (Centerville, Ohio) |
| ABSTRACT | A skin protective composition includes at least one functional inhibitor of an acid sphingomyelinase (FIASM) in a dermatologically acceptable carrier. A method of ameliorating photosensitivity in a subject includes topically administering the skin protective composition to a subject, where the therapeutically effective amount is demonstrated to reduce or eliminate inflammation, microvesicle particle release, erythema, or a combination thereof. In another embodiment, a method inhibits the release of microvesicle particles from skin cells. In another embodiment, a method reduces side effects resulting from a topical photodynamic therapy treatment. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 41/0061 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245715 | LAUGHLIN et al. |
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| APPLICANT(S) | UNIVERSITY OF ALASKA FAIRBANKS (Fairbanks, Alaska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernard LAUGHLIN (Fairbanks, Alaska); Kelly DREW (Fairbanks, Alaska) |
| ABSTRACT | The present disclosure provides a pharmaceutical composition comprising i) an A1 adenosine receptor (A1AR) agonist, ii) an A1AR antagonist, and iii) an anticholinergic. Kits utilizing i) an A1 adenosine receptor (A1AR) agonist, ii) an A1AR antagonist, and iii) an anticholinergic are also provided, as well as methods utilizing the described pharmaceutical compositions and kits. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442232 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7076 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245725 | BAUER |
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| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Daniel E. BAUER (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for improving safety and efficacy of hemoglobinopathy treatment by assessing the presence or absence of a given SNP polymorphism that affects CRISPR/Cas mediated reinduction of fetal hemoglobin (i.e., β-globin) in a cell by disrupting BCL11A expression at the genomic level. |
| FILED | Tuesday, May 10, 2022 |
| APPL NO | 18/290405 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245733 | Ward et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); U.S. Govenment Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey Ward (San Francisco, California); Qizhi TANG (San Francisco, California); Peter STOCK (San Francisco, California); Gaetano FALEO (San Francisco, California); Gopika NAIR (San Francisco, California); Matthias HEBROK (San Francisco, California); Wenhan CHANG (San Francisco, California); Thuy VO (San Francisco, California); Jeffrey A. BLUESTONE (San Francisco, California); Elenora DE KLERK (San Francisco, California) |
| ABSTRACT | Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0024 (20130101) A61K 35/39 (20130101) A61K 35/55 (20130101) Original (OR) Class A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0617 (20130101) C12N 5/0676 (20130101) C12N 2506/02 (20130101) C12N 2506/078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245751 | WANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiao-Jing WANG (West Sacramento, California); Christian D. YOUNG (Denver, Colorado) |
| ABSTRACT | Embodiments of the instant disclosure generally relate to formulations for preserving, storing, administering and/or delivering Smad7 polypeptides or fragments thereof to a subject to reduce the risk of onset, or to prevent or treat a health condition. Certain embodiments relate to administering and/or delivering Smad7 formulations to treat a subject having adverse effects due to excessive inflammation, radiation, chemotherapy, other anti-tumor treatments, infection and/or necrosis. In some embodiments, a Smad7 polypeptide can include a Smad7 fragment as part of a fusion polypeptide formulated for topical or dermal delivery to a subject further including a gelling agent to improve efficacy of the formulation. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/599948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 47/38 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245762 | JEWELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. JEWELL (Silver Spring, Maryland); Joshua M. GAMMON (Cambridge, Massachusetts); Lisa H. TOSTANOSKI (Boston, Massachusetts); Jonathan BROMBERG (Baltimore, Maryland) |
| ABSTRACT | The present disclosure is directed to systems, compositions and methods for promoting immune tolerance to an antigen in a subject. Systems and methods provide for introducing directly into at least one lymph node(s) of the subject a therapeutically effective amount of a composition comprising an antigen associated with an autoimmune disease or disorder, in combination with a carrier comprising an immune modulatory agent such that an immune response to said antigen is inhibited or suppressed in the subject. The present disclosure is also directed to systems, compositions and methods for the treatment and/or prevention of autoimmune diseases and conditions, and in particular type 1 diabetes and graft rejection. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 18/261203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2039/577 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245786 | Gray et al. |
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| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Lewis C. Cantley (Cambridge, Massachusetts); Sindhu Carmen Sivakumaren (Boston, Massachusetts); Theresa Manz (Somerville, Massachusetts); Eric Wang (Brookline, Massachusetts); Wenzhi Ji (Boston, Massachusetts); Eric S. Fischer (Chestnut Hill, Massachusetts); Katherine Donovan (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions by modulating (e.g., reducing) the level or activity of at least one of PIP4K2A, PIP4K2B, and PIP4K2C. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 18/269122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 47/55 (20170801) Original (OR) Class Heterocyclic Compounds C07D 401/14 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245791 | Wertheim et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Wertheim (Tucson, Arizona); Kyle Koss (Tucson, Arizona); Yangxi Liu (Tucson, Arizona) |
| ABSTRACT | The present invention features compositions and methods for the localization and concentration of various growth factors (e.g., vascular endothelial growth factor (VEGF), or an angiopoietin-1 (ANG1) protein, or an angiopoietin-2 (ANG2) protein) within a scaffold structure. The present invention may also be used to promote the rebuilding of vasculature on de-celled organs (e.g., a kidney) or artificial organs. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566564 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1866 (20130101) A61K 38/1891 (20130101) A61K 47/64 (20170801) Original (OR) Class A61K 47/545 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245806 | Creton |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbert Creton (Providence, Rhode Island) |
| ABSTRACT | A method of treating or preventing a neurodegenerative disease or disorder such as Alzheimer's disease, or Down syndrome is described. The method includes administering a therapeutically effective amount of a CsA-type drug and/or an INDY-type to a subject in need thereof. Methods of identifying a neuromodulating drug using zebrafish larvae are also described. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/562032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/18 (20130101) A61K 31/44 (20130101) A61K 31/47 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) A61K 31/138 (20130101) A61K 31/353 (20130101) A61K 31/381 (20130101) A61K 31/433 (20130101) A61K 31/495 (20130101) A61K 31/498 (20130101) A61K 31/517 (20130101) A61K 31/635 (20130101) A61K 31/4174 (20130101) A61K 31/4184 (20130101) A61K 31/4439 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 49/0008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245819 | BRISBOIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth BRISBOIS (Athens, Georgia); Manjyot Kaur CHUG (Athens, Georgia) |
| ABSTRACT | Disclosed herein are disinfection inserts comprising a fiber optic and a polymer surrounding at least a portion of the fiber optic (and methods of making and using the same). The polymer comprises a NO donor molecule that releases NO upon illumination of the polymer by the fiber optic. The disinfection inserts can be inserted into tubing, catheters, and/or extracorporeal devices and illuminated to release NO from the polymer. The released NO inactivates pathogens on or within the tubing, catheter, and/or extracorporeal device. The disinfection insert can be configured for removable attachment to the tubing, catheter, and/or extracorporeal device, such that it can be periodically replaced. Furthermore, the disinfection insert can be placed in optical communication with a controllable light source. The controllable light source can be coupled to a light source controller. The intensity and wavelength of the light can be varied to change the flux of NO. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/561613 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/20 (20130101) A61L 2/24 (20130101) A61L 2/26 (20130101) Original (OR) Class A61L 2202/11 (20130101) A61L 2202/14 (20130101) A61L 2202/24 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/00 (20130101) A61M 2025/0019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245849 | BRETON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Marc D. BRETON (Charlottesville, Virginia); Stephen D. PATEK (Charlottesville, Virginia); Boris P. KOVATCHEV (Charlottesville, Virginia) |
| ABSTRACT | An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/599531 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/486 (20130101) A61B 5/746 (20130101) A61B 5/4839 (20130101) A61B 5/4866 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) Original (OR) Class A61M 5/168 (20130101) A61M 5/172 (20130101) A61M 5/1723 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/502 (20130101) A61M 2205/507 (20130101) A61M 2205/3576 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/65 (20180101) G16H 20/17 (20180101) G16H 40/60 (20180101) G16H 40/63 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245856 | Krishnan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children’s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddharth Krishnan (Cambridge, Massachusetts); Daniel Anderson (Framingham, Massachusetts); Robert S. LANGER (Newton, Massachusetts); Arnab Rudra (Brookline, Massachusetts); Nima Khatib (Somerville, Massachusetts); Laura O'Keeffe (Nanaimo, Canada) |
| ABSTRACT | Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., <3 cm3), lightweight (e.g., <2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., <5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo. Additionally, disclosed herein is a platform for the long-term in vivo closed loop delivery of emergency rescue drugs. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514373 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/148 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245915 | Noble et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBIL UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack H. Noble (Nashville, Tennessee); Robert F. Labadie (Nashville, Tennessee); Benoit M. Dawant (Nashville, Tennessee) |
| ABSTRACT | A patient-customized electrode array (EA) includes a plurality of electrodes, {Ei}, assembled in a pre-curved form, wherein the curvature of the EA at the i-th electrode Ei is characterized with a curvature that matches the curvature of the i-th point Pi of a structure curve in the cochlea of a patient where the i-th electrode Ei is to be placed, wherein i=1, 2, 3, . . . N, N is an integer greater than zero. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391840 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/1076 (20130101) A61B 6/032 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2034/108 (20160201) A61B 2505/05 (20130101) A61B 2562/043 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0541 (20130101) A61N 1/36039 (20170801) Original (OR) Class Image Data Processing or Generation, in General G06T 7/12 (20170101) G06T 7/181 (20170101) G06T 11/005 (20130101) G06T 2207/30008 (20130101) G06T 2211/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245937 | Khokhlova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Vera Khokhlova (Seattle, Washington); Pavel Rosnitskiy (Seattle, Washington); Petr V. Yuldashev (Moscow, Russian Federation); Tatiana D. Khokhlova (Seattle, Washington); Oleg A. Sapozhnikov (Seattle, Washington); George R. Schade (Seattle, Washington) |
| ABSTRACT | Transrectal ultrasound probe for boiling histotripsy ablation of prostate are presented herein. In one embodiment, a method for a transrectal ultrasound treatment uses high intensity focused ultrasound (HIFU). The method includes: generating a boiling histotripsy (BH) therapy ultrasound by a therapy transducer in a frequency range of 1 MHz to 2.8 MHz and a surface intensity range of 10 W/cm2 to 80 W/cm2. The therapy transducer may be about 50 mm long and about 35 mm wide. The method also includes applying the therapy ultrasound by directing ultrasound pulses having ultrasound shock waves to a target tissue at a focal depth of 2.5 cm to 5.5 cm; generating at least one μm-scale vapor bubble at a target region; growing the at least one vapor bubble to at least one mm-scale bubble; and mechanically disintegrating a surrounding tissue by interactions between mm-scale bubbles and the ultrasound shock waves within a pulse. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/438692 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/445 (20130101) A61B 2017/00274 (20130101) A61B 2017/320069 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/022 (20130101) Original (OR) Class A61N 2007/0039 (20130101) A61N 2007/0052 (20130101) A61N 2007/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246042 | Dick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jeffrey Edward Dick (West Lafayette, Indiana); Guillermo Sebastian Colon Quintana (West Lafayette, Indiana); Thomas Bradley Clarke (Durham, North Carolina) |
| ABSTRACT | A method for spontaneous emulsification comprising mixing (i) an aqueous phase comprising a partitioning agent which contains a partitioning anion which determines the hydrophilicity of the partitioning agent, alone or in further combination with an electrolyte, with (ii) an oil phase comprising a phase-transfer agent, wherein the phase-transfer agent creates and promotes an interfacial flux of an anion and promotes the formation of droplets at a liquid-liquid interface of the aqueous phase and oil phase; and a method for spontaneous electro-emulsification comprising generating an ionic flux across the liquid-liquid interface by applying an electrical potential. |
| FILED | Thursday, November 09, 2023 |
| APPL NO | 18/388359 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/411 (20220101) Original (OR) Class B01F 23/4145 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246076 | Mao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chih-Ping Mao (Baltimore, Maryland); Shih-Chin Wang (Baltimore, Maryland); Jie Xiao (Baltimore, Maryland); T.C. Wu (Baltimore, Maryland); Chien-Fu Hung (Timmonium, Maryland) |
| ABSTRACT | Described are chips for detecting a target in a sample including a microfluidic flow chamber comprising one or more flow channels having a capture surface and at least one micromixer. Described are methods of using this chip wherein targets are identified by total internal reflection fluorescence (TIRF). |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/437439 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 25/43172 (20220101) B01F 25/431971 (20220101) B01F 33/30 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2200/10 (20130101) B01L 2300/12 (20130101) B01L 2300/0636 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/552 (20130101) G01N 21/648 (20130101) G01N 21/6428 (20130101) G01N 33/543 (20130101) G01N 33/57484 (20130101) G01N 2021/6439 (20130101) G01N 2021/6482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246902 | MAJER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV CR, V.V.I. (Prague, Czech Republic) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pavel MAJER (Sykesville, Maryland); Lukas TENORA (Praha, Czech Republic); Katerina NOVOTNA (Dolni Libchavy, Czech Republic); Ivan SNAJDR (Praha, Czech Republic); Barbara SLUSHER (Kingsville, Maryland); Rana RAIS (West Friendship, Maryland); Jesse ALT (Nottingham, Maryland) |
| ABSTRACT | The present disclosure provides prodrugs of 6-diazo-5-oxo-L-norleucine (DON) for use in treating or preventing a disease, disorder, or condition in which the inhibition of glutamine-utilizing enzymes provides a benefit. |
| FILED | Friday, April 29, 2022 |
| APPL NO | 18/557760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/655 (20130101) Acyclic or Carbocyclic Compounds C07C 245/18 (20130101) Original (OR) Class Heterocyclic Compounds C07D 209/20 (20130101) C07D 213/56 (20130101) C07D 233/06 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 471/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246903 | McHardy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanton McHardy (San Antonio, Texas); Michael W. Tidwell (San Antonio, Texas); Andrew J. Brenner (San Antonio, Texas); Ratna K. Vadlamudi (San Antonio, Texas) |
| ABSTRACT | Certain embodiments are directed to compounds, pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, that are ER ligands and particularly to such compounds that are ERβ selective and/or ERβ specific ligands. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/558765 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 251/44 (20130101) Original (OR) Class C07C 311/16 (20130101) C07C 311/32 (20130101) C07C 2602/08 (20170501) C07C 2602/10 (20170501) Heterocyclic Compounds C07D 231/56 (20130101) C07D 239/34 (20130101) C07D 257/04 (20130101) C07D 317/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246909 | Messick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Troy E. Messick (Upper Darby, Pennsylvania); Garry R. Smith (King of Prussia, Pennsylvania); Allen B. Reitz (Lansdale, Pennsylvania); Paul M. Lieberman (Wynnewood, Pennsylvania); Mark E. McDonnell (Lansdale, Pennsylvania); Yan Zhang (Fort Washington, Pennsylvania); Marianne Carlsen (Yardley, Pennsylvania); Shuai Chen (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/408389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/404 (20130101) A61K 31/422 (20130101) A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/435 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/541 (20130101) A61K 31/551 (20130101) A61K 31/4155 (20130101) A61K 31/4375 (20130101) A61K 31/4439 (20130101) A61K 31/4725 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/08 (20130101) Original (OR) Class C07D 277/62 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/10 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 413/10 (20130101) C07D 417/10 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 471/08 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) C07D 487/08 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246942 | FENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); REACTION BIOLOGY CORPORATION (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbo FENG (Malvern, Pennsylvania); Sung Ok YOON (Columbus, Ohio) |
| ABSTRACT | Described herein are compounds that are kinase inhibitors. The disclosed compounds have improved properties that lead to specific targeting of kinases without inhibiting the activity of related enzymes including, making them useful for therapeutic intervention in a variety of disorders and disease in which inhibition of the kinase can be clinically useful, e.g., Alzheimer's disease and other neurodegenerative diseases. In further aspects, the disclosed compounds can be used in methods of treating a neurodegenerative disease associated with inflammation, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, epilepsy, stroke, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), or a disease or disorder such as deafness, glaucoma, organ failure, or cancers, including, but not limited to, those susceptible to combination therapy with epigenetic targets such as those associated with bromodomain (BRD) proteins, histone deacetylases (HDACs), and the like. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 18/249147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4155 (20130101) Heterocyclic Compounds C07D 409/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246951 | MITSUYA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| ASSIGNEE(S) | NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE (Tokyo, Japan) |
| INVENTOR(S) | Hiroaki MITSUYA (Tokyo, Japan); Hirokazu TAMAMURA (Tokyo, Japan); Nobuyo KUWATA (Tokyo, Japan) |
| ABSTRACT | A compound represented by the following general formula (1) that has an activity of suppressing a virus protease and an antiviral activity and has a low toxicity to a host cell: |
| FILED | Thursday, July 14, 2022 |
| APPL NO | 17/928746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246954 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TheRas, Inc. (Palo Alto, California); Leidos Biomedical Research, Inc. (Frederick, Maryland); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Wang (Dallas, Texas); Rui Xu (Dallas, Texas); Eli Wallace (Loveland, Colorado); Felice Lightstone (Fremont, California); Yue Yang (Foster City, California); Paola Bisignano (San Francisco, California); Anna Elzbieta Maciag (Frederick, Maryland); David Michael Turner (Frederick, Maryland); Dhirendra Kumar Simanshu (Frederick, Maryland); Albert Hay Wah Chan (Frederick, Maryland); Zuhui Zhang (Millbrae, California); Christopher John Brassard (Frederick, Maryland); Tao Liao (Frederick, Maryland) |
| ABSTRACT | Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 18/546317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 487/08 (20130101) C07D 487/10 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246970 | RILEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW RILEY (CHICAGO, Illinois); MALAIKA ARGADE (CHICAGO, Illinois); LISA RUSALI (CHICAGO, Illinois); CAROLYN STRAUB (CHICAGO, Illinois); KYLE KREMILLER (CHICAGO, Illinois) |
| ABSTRACT | In one aspect, the disclosure relates to a scaffold for a class of small molecules that selectively inhibit the α3β4 nicotinic acetylcholine receptor (nAChR) subtype, as well as molecules constructed using the scaffold and syntheses thereof. In some aspects, the scaffold can be used as a basis for synthesizing additional molecules capable of selectively inhibiting other nAChR subtypes. In a further aspect, the disclosed small molecules can be used as molecular probes to investigate the function of different nAChR subtypes and as potential treatments for addiction and other diseases. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 18/580788 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 31/444 (20130101) A61K 31/4709 (20130101) A61K 31/4725 (20130101) Heterocyclic Compounds C07D 225/06 (20130101) C07D 401/04 (20130101) C07D 405/04 (20130101) C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247033 | SCHIEF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William SCHIEF (Encinitas, California); Jon STEICHEN (San Diego, California); Torben SCHIFFNER (San Diego, California); Xiaozhen HU (San Diego, California); Christoper COTTRELL (Poway, California) |
| ABSTRACT | The present invention relates to glycan-masked and membrane-tethered SARS-CoV-2 RBD vaccine constructs and methods for making and administering the same. The present invention also encompasses a general vaccine platform for coronaviruses. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 18/002611 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/03 (20130101) C07K 2319/91 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16022 (20130101) C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247035 | Mourtada et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lytica Therapeutics, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Lytica Therapeutics, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Rida Mourtada (Boston, Massachusetts); Warren A. Dorsch (Boston, Massachusetts) |
| ABSTRACT | Provided are stapled antimicrobial peptides (i.e., StAMPs) and methods of using the same (e.g., for treating bacterial infections caused by Gram-negative bacteria). In certain embodiments, the stapled peptides are based on the amino acid sequence of the antimicrobial peptide Esculentin-1A but include certain modifications that have been found to confer advantageous properties (e.g., improved antimicrobial activity, selectivity for killing Gram-negative bacteria, and/or reduced toxicity). Also provided are unstapled peptides which can serve as synthetic precursors to the stapled peptides provided herein. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/24 (20130101) A61K 47/544 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/001 (20130101) C07K 14/463 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247038 | SPEES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| ASSIGNEE(S) | The University of Vermont and State Agriculture College (Burlington, Vermont) |
| INVENTOR(S) | Jeffrey L. SPEES (Burlington, Vermont); Benjamin LIEBMAN (Burlington, Vermont) |
| ABSTRACT | The invention features isolated protein complexes and compositions and methods for use thereof. In embodiments, the isolated protein complexes are used for treating conditions associated with reperfusion injury, hypofusion, and/or low/no-reflow. The isolated protein complexes comprise a fusion protein complexed with basic fibroblast growth factor (FGF2), hepatocyte growth factor (HGF), or vascular endothelial growth factor (VEGF). The fusion protein contains an immunoglobulin G (IgG) Fc domain fused to a polypeptide (e.g., Jagged1, a growth factor, or a cytokine). |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431592 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/50 (20130101) Original (OR) Class C07K 14/70596 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247047 | Ware et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California); PFIZER INC. (New York, New York) |
| ASSIGNEE(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California); PFIZER INC. (New York, New York) |
| INVENTOR(S) | Carl F. Ware (Solana Beach, California); John Sedy (San Diego, California); Tigran Aivazian (San Diego, California); Brian Miller (San Diego, California); Natasha K. Crellin (San Carlos, California) |
| ABSTRACT | The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/17 (20130101) A61K 38/177 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) A61K 47/68 (20170801) Peptides C07K 14/71 (20130101) Original (OR) Class C07K 14/715 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 19/00 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247055 | Kosik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kenneth Kosik (Santa Barbara, California); Jennifer Rauch (Santa Barbara, California) |
| ABSTRACT | Provided are novel methods of inhibiting the propagation of pathological forms of tau between cells of the central nervous system by administration of an inhibitor of LRP1. LRP1 was discovered to facilitate the endocytosis of pathological forms of tau which enables the propagation of tau aggregates and resulting neurodegeneration. These methods enable the prevention and treatment of various tauopathies, such as Alzheimer's, chronic traumatic encephalopathy, corticobasal degeneration, and others. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/439648 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/20 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247056 | Hansen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Hansen (North Haven, Connecticut); Peter M. Glazer (Guilford, Connecticut); Richard H. Weisbart (Los Angeles, California); Robert N. Nishimura (Santa Monica, California); Grace Chan (Monterey Park, California) |
| ABSTRACT | Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/596375 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/44 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247250 | Tota et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ember M. Tota (La Jolla, California); Neal Devaraj (La Jolla, California) |
| ABSTRACT | Provided herein are, inter alia, compositions and methods for modifying a DNA molecule. The methods include contacting a DNA molecule with a transglycosylase enzyme and a Pre-queuosinel (preQi) analog or derivative, wherein a guanine nucleobase within a hairpin structure in the DNA molecule is exchanged for the preQi analog or derivative. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 18/563336 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1077 (20130101) C12N 15/102 (20130101) Original (OR) Class Enzymes C12Y 204/02029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247251 | Ares et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manuel Ares (Santa Cruz, California); Logan Mulroney (Santa Cruz, California); Jenny Vo (Santa Cruz, California); Mark Akeson (Santa Cruz, California) |
| ABSTRACT | Provided are methods of adding a polymer of non-canonical nucleotides to the 3′ end of a ribonucleic acid (RNA). In certain embodiments, the methods comprise combining an RNA, a polynucleotide-3′ nucleotidyl transferase, and non-canonical nucleotides, in a reaction mixture under conditions in which the polynucleotide-3′ nucleotidyl transferase adds a polymer of the non-canonical nucleotides to the 3′ end of the RNA. Such methods may further include analyzing the RNA using a nanopore. According to some embodiments, the methods include identifying the polymer of non-canonical nucleotides added to the 3′ end of the RNA, and determining the junction between the 3′ end of the RNA and the polymer of non-canonical nucleotides to identify the 3′ end of the RNA. Kits that find use, e.g., in practicing the methods of the present disclosure are also provided. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587665 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1282 (20130101) C12N 15/102 (20130101) Original (OR) Class Enzymes C12Y 207/07052 (20130101) C12Y 207/07072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247252 | Gao |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Jianmin Gao (Newton, Massachusetts) |
| ABSTRACT | This patent document provides novel compounds as warheads for therapeutic or diagnostic agents. Advantages of the agents modified with the warheads include low off-target conjugation and minimized immunogenicity due to the reversible covalent bonding between the warheads and the targets. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405421 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Peptides C07K 7/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247261 | Green et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainsville, Florida) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts); UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainsville, Florida) |
| INVENTOR(S) | Alexander Arthur Green (Chestnut Hill, Massachusetts); Yu Zhou (Gainesville, Florida); Peike Sheng (Gainesville, Florida); Mingyi Xie (Gainesville, Florida) |
| ABSTRACT | Provided herein are methods, compositions and systems comprising synthetic nucleic acid molecules that enable inducible or conditional pri-miRNA processing, preferably in mammalian cells in vivo. Provided herein are synthetic nucleic acid molecules referred to as Orthogonal RNA Interference induced by Trigger RNA (ORIENTR) that switches between an inactive form and an active form upon interaction with one or more specific RNA-trigger molecules, which can be e.g., a synthetic RNA-trigger, or a disease-specific RNA signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize a disease state of a cell. The interaction between the RNA-trigger molecules and the ORIENTR is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a correctly folded pri-miRNA scaffold substrate that can be processed by proteins of the RNAi pathway (such as Dicer), leading to RNAi-mediated repression of a target gene. Also provided herein are methods of using such ORIENTR molecules for the treatment or prevention of a disease in a subject, as well as detecting the presence or absence of a target RNA in a biological sample or in vivo. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393408 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/32 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247262 | Clarke et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan E. Clarke (Chicago, Illinois); Bradley J. Merrill (Chicago, Illinois); Matthew S. MacDougall (Chicago, Illinois); Hannah M. Pennington (Chicago, Illinois); Brian R. Shy (Chicago, Illinois) |
| ABSTRACT | A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/464374 |
| CURRENT CPC | Peptides C07K 2319/06 (20130101) C07K 2319/80 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/121 (20130101) C12N 2310/122 (20130101) C12N 2310/123 (20130101) Enzymes C12Y 603/02019 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247269 | Dorr et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hennepin Healthcare Research Institute (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey R. Dorr (Minneapolis, Minnesota); Ajay K. Israni (Eden Prairie, Minnesota) |
| ABSTRACT | A cell line includes a genetic modification at a genetic locus that affects metabolism of a drug in a manner similar to a human subject having a genotype that affects metabolism of the drug. A method for making such a cell line generally includes identifying a locus and allelic variants at the locus in a human that affect metabolism of the drug, providing a parental cell line that comprises the locus that affects metabolism of the drug in the human subject, and introducing a genetic modification into the parental cell at the locus, thereby forming a variant cell line comprising an allelic variant at the locus having the genetic modification. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591645 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/106 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247270 | Dorr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hennepin Healthcare Research Institute (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey R. Dorr (Minneapolis, Minnesota); Ajay K. Israni (Eden Prairie, Minnesota) |
| ABSTRACT | A cell line includes a genetic modification at a genetic locus that affects metabolism of a drug in a manner similar to a human subject having a genotype that affects metabolism of the drug. A method for making such a cell line generally includes identifying a locus and allelic variants at the locus in a human that affect metabolism of the drug, providing a parental cell line that comprises the locus that affects metabolism of the drug in the human subject, and introducing a genetic modification into the parental cell at the locus, thereby forming a variant cell line comprising an allelic variant at the locus having the genetic modification. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591760 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/106 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247275 | IAVARONE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio IAVARONE (Sunny Isles Beach, Florida); Anna LASORELLA (New York, New York); Raul RABADAN (New York, New York) |
| ABSTRACT | The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/416643 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/71 (20130101) C07K 14/82 (20130101) C07K 16/18 (20130101) C07K 16/2863 (20130101) C07K 2319/00 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/62 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) G01N 2333/91205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247299 | HULL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Christina Marie HULL (Middleton, Wisconsin); Mingwei HUANG (Madison, Wisconsin); Sebastien Claude Ortiz (Madison, Wisconsin) |
| ABSTRACT | A method of testing compounds for activity to inhibit germination of spores. The method includes the steps of (a) providing bacterial, fungal, or plant spores transformed to contain and express a detectable marker, wherein the marker when expressed, is operationally linked to a spore-specific or yeast-specific protein, in a medium and under environmental conditions in which the spores will germinate, and measuring a first signal output generated by the marker prior to the spores initiating germination; (b) contacting the spores of step (a) with a compound whose activity to inhibit germination of spores is to be measured; (c) incubating the spores of step (b) under environmental conditions and for a time wherein spores not treated with the compound will germinate; and (d) determining extent of germination of the spores by measuring a second signal output generated by the marker, wherein a difference between the first signal output and the second signal output is proportional to the extent of germination of the spores. Also described are compositions of matter for inhibiting spore germination in vitro and in vivo. |
| FILED | Wednesday, April 10, 2024 |
| APPL NO | 18/631396 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/10 (20130101) A01N 37/44 (20130101) A01N 41/12 (20130101) A01N 47/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/24 (20130101) A61K 31/137 (20130101) A61K 31/145 (20130101) A61K 31/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class C12Q 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247301 | Gopalan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venkat Gopalan (Columbus, Ohio); Eleanor Bashian (Columbus, Ohio); Pankajavalli Thirugnanasambantham (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to a diagnostic assay to detect classic inborn galactosemia. The assay comprises detecting defective galactose metabolism using a substrate-specific recombinant phosphatase derived from Salmonella. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/42 (20130101) Original (OR) Class C12Q 1/54 (20130101) Enzymes C12Y 301/03023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/916 (20130101) G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247313 | Johnson |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bankole A. Johnson (Charlottesville, Virginia) |
| ABSTRACT | The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394729 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/942 (20130101) G01N 33/6872 (20130101) G01N 2800/50 (20130101) G01N 2800/307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248063 | CLOWERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington); TEXAS A and M UNIVERSITY (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian H. CLOWERS (Pullman, Washington); Elvin CABRERA (Kennewick, Washington); David RUSSELL (Chappell Hill, Texas); Arthur LAGANOWSKY (College Station, Texas) |
| ABSTRACT | Examples include multidimensional detecting of properties of particles, including a first measuring device measuring a property of particles, in a first domain, outputting the particles with a sequence stepped second domain modulation corresponds to first domain measurement values. The sequence steps have a step interval extending in the first domain and changing from step to step according to a trajectory. For sequence steps having a preceding step, the step's second domain modulation state differs from the preceding step. A second measuring device decodes the particles' respective first domain measurements by demodulating the sequence stepped second domain modulation, and measures a second property of the particles, over a measuring interval in the first domain from an interval start point to an interval end point. The interval start point and the interval end point are synchronized to the step start and to the step stop. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422476 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/623 (20210101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248078 | Dzirasa et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kafui Dzirasa (Durham, North Carolina); Elizabeth Ransey (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are compositions for use in methods of evaluating gap junction formation, methods of interrogating the docking interactions between connexins, and methods of high-throughput quantification of gap junction hemichannel docking. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/564491 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5032 (20130101) G01N 33/5076 (20130101) Original (OR) Class G01N 2333/976 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248096 | Hahn et al. |
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| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Sihoun Hahn (Clyde Hill, Washington); Christopher Collins (Seattle, Washington); Remwilyn Dayuha (Lynnwood, Washington); Fan Yi (Shoreline, Washington) |
| ABSTRACT | Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435892 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6854 (20130101) Original (OR) Class G01N 2800/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248101 | Levine et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mark A. Levine (Washington, District of Columbia); Ifechukwude C. Ebenuwa (Washington, District of Columbia); Pierre-Christian Violet (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Mark A. Levine (Washington, District of Columbia); Ifechukwude C. Ebenuwa (Washington, District of Columbia); Pierre-Christian Violet (Bethesda, Maryland) |
| ABSTRACT | The invention provides a method involving assessing the vitamin C renal leak status of a human subject, vitamin C renal leak being the clinically inappropriate presence of vitamin C in urine. The method comprises assaying for the concentration of vitamin C in a plasma sample and in collected urine output, whereby the presence of vitamin C in the collected urine output and a concentration of vitamin C in the plasma sample less than the Minimum Elimination Threshold (MET) indicates the presence of vitamin C renal leak. Vitamin C renal leak also can be quantified by determining the fractional excretion of vitamin C (FeVC), which is a measurement of the degree of urinary vitamin C excretion relative to plasma vitamin C concentration corrected by creatinine clearance. The invention also provides a test kit for assessing vitamin C renal leak and a test kit for assessing FeVC. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 18/563663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/375 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/64 (20130101) G01N 30/88 (20130101) G01N 33/82 (20130101) Original (OR) Class G01N 2030/027 (20130101) G01N 2030/8813 (20130101) G01N 2800/042 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248206 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyungkyi Lee (Rochester, Minnesota); Matthew W. Urban (Rochester, Minnesota); James F. Greenleaf (Rochester, Minnesota) |
| ABSTRACT | Systems and methods for Plane Wave Compounding (“PWC”) are provided for improving image quality with reduced phase shift errors. The initial phase difference (“IPD”) between two PW transmissions is related to the phase shift error. When the absolute value of IPD is larger than π/2, the phase shift error occurs. An Initial-Phase-Compensated PWC (“IPCPWC”) method may be used to compensate the initial phase of echo signals from each PW transmit and maintain the absolute value of IPD smaller than π/2. IPCPWC methods may also include increased motion signal-to-noise ratio and reduced jitter. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 18/561254 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/485 (20130101) A61B 8/5207 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/8995 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/50 (20130101) G06T 7/20 (20130101) G06T 2207/10132 (20130101) G06T 2207/20212 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249396 | Jha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhinav Kumar Jha (St. Louis, Missouri); Md Ashequr Rahman (St. Louis, Missouri); Zitong Yu (St. Louis, Missouri); Barry Siegel (St. Louis, Missouri) |
| ABSTRACT | A system for single-photon emission computed tomography (SPECT) is provided. The system includes a computer device comprises at least one processor in communication with at least one memory device. The at least one processor is programmed to: a) store a model trained to denoise computer tomography (CT) scans of a subject being examined; b) receive a CT scan of a first subject being examined; c) execute the model with the CT scan of the first subject as an input, wherein the model performs denoising on the CT scan while accounting for an observer loss function; and d) output a denoised-CT scan of the first subject. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/416567 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/70 (20240101) Original (OR) Class G06T 7/0012 (20130101) G06T 2207/10108 (20130101) G06T 2207/20081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249449 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shen Zhao (Sunnyvale, California); Michael Salerno (Belmont, California); Junyu Wang (Menlo Park, California) |
| ABSTRACT | A method for simultaneous multislice (SMS) magnetic resonance imaging (MRI) acquisition and image reconstruction includes a) using an MRI apparatus, simultaneously i) exciting multiple imaging slices with a phase modulation strategy used to distribute the image content over an extended phase-encoding field of view (FOV), and ii) acquiring data from the multiple slices using a sampling strategy comprising a k-space under-sampling pattern over an extended phase-encoding FOV k-space matrix; and b) reconstructing images comprising the multiple slices over the extended phase-encoded FOV using an image reconstruction technique. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/420104 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4835 (20130101) G01R 33/5611 (20130101) Image Data Processing or Generation, in General G06T 11/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249453 | Jha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhinav Kumar Jha (St. Louis, Missouri); Zitong Yu (St. Louis, Missouri); Md Ashequr Rahman (St. Louis, Missouri) |
| ABSTRACT | A system for single-photon emission computed tomography (SPECT) is provided. The system includes a computer device comprises at least one processor in communication with at least one memory device. The at least one processor is programmed to: a) store a model trained to generate an attenuation map of a subject being examined; b) receive a scatter-energy window projection of a first subject to be examined; c) execute the model with the scatter-energy window projection of the first subject as an input, wherein the model generates an attenuation map; d) receive a photopeak-energy window projection of the first subject to be examined; and e) perform attenuation compensation on the photopeak-energy window projection using the generated attenuation map. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/416578 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) A61B 6/5282 (20130101) Image Data Processing or Generation, in General G06T 11/006 (20130101) Original (OR) Class G06T 2210/41 (20130101) G06T 2211/441 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249796 | Hnisz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Denes Hnisz (Cambridge, Massachusetts); Richard A. Young (Boston, Massachusetts); Diego R. Borges-Rivera (Belmont, Massachusetts); Abraham S. Weintraub (Cambridge, Massachusetts); Xiong Ji (Cambridge, Massachusetts); Daniel B. Dadon (Cambridge, Massachusetts); Zi Peng Fan (Waltham, Massachusetts); Tong Ihn Lee (Somerville, Massachusetts) |
| ABSTRACT | Work described herein reveals 3D regulatory landscapes of hESCs representative of early human development. This work also demonstrates that cohesin-associated CTCF loops, and the cohesin-associate enhancer-promoter loops within them, dominate the organization of TADs. The CTCF-CTCF loops form a chromosomal scaffold of insulated neighborhoods that are largely preserved in vertebrates, and enhancer-promoter interactions occur within these neighborhoods. Genes are regulated in the context of conserved insulated neighborhood structures. Loss of neighborhood structures occurs frequently in cancer cells, and proto-oncogenes can be activated by genetic alterations that disrupt specific 3D chromosome structures. |
| FILED | Thursday, November 02, 2023 |
| APPL NO | 18/386551 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6809 (20130101) C12Q 1/6841 (20130101) C12Q 1/6886 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 25/00 (20190201) G16B 25/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249840 | Passerini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Siemens Medical Solutions USA, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tiziano Passerini (Plainsboro, New Jersey); Retta El Sayed (Atlanta, Georgia) |
| ABSTRACT | For predicting stroke risk, an artificial intelligence rapidly generates flow information from input of geometric parameters of a carotid of a patient. An image processor predicts the stroke risk from the flow information. In one approach, the values of the geometric parameters of the carotid of the patient are perturbed based on uncertainty. The artificial intelligence generates candidate flow information for each perturbation. The candidate flow information sufficiently matching a measurement of flow for the patient is used as the flow information for stroke risk prediction. |
| FILED | Thursday, May 25, 2023 |
| APPL NO | 18/323566 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/10 (20170101) G06T 7/0012 (20130101) G06T 7/529 (20170101) G06T 2207/10081 (20130101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/30104 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249847 | Rappaport Kengo Watanabe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute for Systems Biology (Seattle, Washington) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington) |
| INVENTOR(S) | Noa Rappaport Kengo Watanabe (Seattle, Washington); Tomasz Wilmanski (Seattle, Washington); Nathan Price (Seattle, Washington) |
| ABSTRACT | Provided are computer-implemented methods, systems and products of determining omic body index and class of a subject. |
| FILED | Thursday, November 16, 2023 |
| APPL NO | 18/511862 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240245823 | Maitland et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan J. Maitland (College Station, Texas); Todd Lawrence Landsman (Ojai, California); Tyler Joseph Touchet (Cypress, Texas); Elizabeth L. Cosgriff-Hernandez (College Station, Texas); Thomas S. Wilson (San Leandro, California) |
| ABSTRACT | An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586901 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/01017 (20240101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/18 (20130101) Original (OR) Class A61L 15/26 (20130101) A61L 15/46 (20130101) A61L 15/425 (20130101) A61L 24/0015 (20130101) A61L 24/0036 (20130101) A61L 24/0094 (20130101) A61L 2300/106 (20130101) A61L 2300/404 (20130101) A61L 2400/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246013 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia); James D. Malloy (Arlington, Virginia) |
| ABSTRACT | A metal foam-based filtration system and method for removing sub-micron particles and contaminants from a gas or fluid flow with the use of ultralow density metal nanowire meshes that have nanometer to micron scale pores for trapping air/fluid-borne particulates. Filters can use metal foams and coated metal foams alone or in tandem. The size and density of pores in the foam can be adjusted with synthesis conditions. Foams with pore size gradients promote the trapping of different sized particulates at different regions of a foam. Multiple rounds of electrodeposition increase the surface area and curvature of a nanowire mesh and strengthen the mesh. A metal and/or a coated metal foam can act as a catalyst or substrate for absorption or adsorption. Varying certain parameters can also impact the quality of the foam. Additionally, nanoparticles of about 300 nm in size can be directly incorporated into the foams. |
| FILED | Thursday, March 07, 2024 |
| APPL NO | 18/598834 |
| CURRENT CPC | Separation B01D 39/2051 (20130101) Original (OR) Class B01D 46/2403 (20130101) B01D 2239/0471 (20130101) B01D 2239/1216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246116 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Technologies Inc. (Markle, Indiana) |
| ASSIGNEE(S) | Sortera Technologies Inc. (Markle, Indiana) |
| INVENTOR(S) | Nalin Kumar (Fort Wayne, Indiana); Manuel Gerardo Garcia, JR. (Austin, Texas) |
| ABSTRACT | A material handling system sorts mixed materials utilizing a combination of x-ray fluorescence and/or a vision system that implements an artificial intelligence system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification. The system is capable of sorting between materials typically found within Zorba, Zebra, and Twitch. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590827 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246117 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Technologies Inc. (Markle, Indiana) |
| ASSIGNEE(S) | Sortera Technologies Inc. (Markle, Indiana) |
| INVENTOR(S) | Nalin Kumar (Fort Wayne, Indiana); Manuel Gerardo Garcia, JR. (Austin, Texas) |
| ABSTRACT | A material handling system sorts mixed materials utilizing a combination of a spectroscopic sensor, such as x-ray fluorescence, and a vision system that implements an artificial intelligence system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification. The system is capable of sorting between materials typically found within Zorba, such as wrought, cast, and extrusion aluminum alloys. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590841 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246123 | GENG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (NEWPORT NEWS, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RONGLI GENG (YORKTOWN, Virginia) |
| ABSTRACT | A method for removing microscopic contaminant particulates by high pressure liquid nitrogen jet cleaning from the inner surface of a superconducting radio frequency cavity or a string of multiple cavities and transporting the removed particulates out of the inner space enclosed by the cleaned surfaces. The cleaning method of the invention suppresses field emission, resulting in an increase of the usable accelerating gradient of the cavities and a reduction of the activated radioactivity in accelerator components around cavities. |
| FILED | Thursday, March 07, 2024 |
| APPL NO | 18/598586 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 3/02 (20130101) B08B 7/0021 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/20 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49014 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246855 | Goulet et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CertainTeed Gypsum, Inc. (Malvern, Pennsylvania); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Remi L. Goulet (Worcester, Massachusetts); Remi Lespiat (Devon, Pennsylvania); Khoudor Keniar (Natick, Massachusetts); Kameron Michael Conforti (Charlotte, North Carolina); Srinivas Garimella (Smyrna, Georgia); Jacob Tjards (Naperville, Illinois); Kristian Lockyear (Evansville, Indiana) |
| ABSTRACT | The present disclosure relates generally to methods for producing stucco compositions useful in making gypsum products. One aspect of the disclosure is a method for producing a stucco composition using dielectric calcination. Another aspect of the disclosure is a production process for a gypsum product using a stucco composition prepared by dielectric calcination. |
| FILED | Tuesday, November 21, 2023 |
| APPL NO | 18/515518 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 11/005 (20130101) Original (OR) Class C04B 28/14 (20130101) C04B 41/5307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246865 | King et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livemore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriella Corrinna Susanna King (Livermore, California); Wyatt L. Du Frane (Livermore, California); Isabel Robin Crystal (Livermore, California); James Timothy Cahill (Livermore, California) |
| ABSTRACT | Flowable fiber composite materials that include at least one fiber component and at least one powder component that form composite particles. Methods of making the fiber composite materials include forming and mixing a suspension and spray drying the suspension to form particles. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421843 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/80 (20130101) Original (OR) Class C04B 35/638 (20130101) C04B 35/62635 (20130101) C04B 35/62655 (20130101) C04B 35/62857 (20130101) C04B 35/62886 (20130101) C04B 35/62892 (20130101) C04B 35/63416 (20130101) C04B 2235/524 (20130101) C04B 2235/3813 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) C04B 2235/5436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246954 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TheRas, Inc. (Palo Alto, California); Leidos Biomedical Research, Inc. (Frederick, Maryland); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Wang (Dallas, Texas); Rui Xu (Dallas, Texas); Eli Wallace (Loveland, Colorado); Felice Lightstone (Fremont, California); Yue Yang (Foster City, California); Paola Bisignano (San Francisco, California); Anna Elzbieta Maciag (Frederick, Maryland); David Michael Turner (Frederick, Maryland); Dhirendra Kumar Simanshu (Frederick, Maryland); Albert Hay Wah Chan (Frederick, Maryland); Zuhui Zhang (Millbrae, California); Christopher John Brassard (Frederick, Maryland); Tao Liao (Frederick, Maryland) |
| ABSTRACT | Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof. |
| FILED | Tuesday, February 15, 2022 |
| APPL NO | 18/546317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 413/14 (20130101) C07D 417/04 (20130101) C07D 417/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 487/08 (20130101) C07D 487/10 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247100 | Cochran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric William Cochran (Ames, Iowa); George A. Kraus (Ames, Iowa); Michael J. Forrester (Ames, Iowa); Aleksei Ananin (Ames, Iowa); Ting-Han Lee (San Jose, California); Aaron David Sadow (Ames, Iowa); Nacu Hernandez (Ames, Iowa); Dhananjay Dileep (Ames, Iowa) |
| ABSTRACT | The present application is directed to a cleavable polymer comprising one or more repeat units containing monomer A and one or more repeat units containing monomer B, wherein repeat unit containing monomer A and repeat unit containing monomer B are as described herein and to a process of preparing such a cleavable polymer. The present application is also directed to a cleavable polymer comprising one or more repeat units containing monomer C and one or more repeat units containing monomer D, wherein repeat unit containing monomer C and repeat unit containing monomer D are as described herein. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397035 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/183 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2367/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247147 | Chandrasekaran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swetha Chandrasekaran (Dublin, California); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | An aerogel includes a three-dimensional printed structure having printed features comprised of two dimensional sheets of a graphene analogue. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/626163 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) Non-metallic Elements; Compounds Thereof; C01B 21/064 (20130101) C01B 32/194 (20170801) C01B 32/198 (20170801) C01B 2204/02 (20130101) C01B 2204/04 (20130101) C01B 2204/22 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247345 | Suzuki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akane Suzuki (Ballston Spa, New York); Bernard Patrick Bewlay (Niskayuna, New York); Chen Shen (Schenectady, New York); Scott Michael Oppenheimer (Niskayuna, New York); Patrick Thomas Brennan (Niskayuna, New York) |
| ABSTRACT | A niobium-silicide based alloy and a turbine having at least a turbine component formed from the niobium-silicide based alloy are provided. The niobium-silicide based alloy comprises: between about 14 atomic percent and about 24 atomic percent titanium (Ti); between about 11 atomic percent and about 19 atomic percent silicon (Si); between about 4 atomic percent and about 8 atomic percent chromium (Cr); between about 2 atomic percent and about 6 atomic percent hafnium (Hf); up to about 4 atomic percent aluminum (Al); between about 0.5 atomic percent and about 1 atomic percent tin (Sn); between about 5 atomic percent and about 15 atomic percent tantalum (Ta); between about 1 atomic percent and about 5 atomic percent tungsten (W); up to about 5 atomic percent rhenium (Re); up to about 5 atomic percent zirconium (Zr); up to about 6 atomic percent yttrium (Y); and a balance of niobium (Nb). |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/156655 |
| CURRENT CPC | Alloys C22C 27/02 (20130101) Original (OR) Class C22C 32/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247412 | Grappe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hippolyte A. Grappe (Copenhagen, Denmark); Felix L. Paulauskas (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hippolyte A. Grappe (Copenhagen, Denmark); Felix L. Paulauskas (Knoxville, Tennessee) |
| ABSTRACT | An apparatus is disclosed for electromagnetically and thermally treating polymeric materials, including PAN and other carbon fiber precursors at large scale at atmospheric pressure, while measuring the temperature in the closed environment of the process chamber. The apparatus is designed for continuous processing, and to be compatible with other stages of existing carbon fiber production lines. It provides direct electromagnetic coupling to the fiber tow(s) in a resonant cavity of one or more microwave waveguide launchers and also provides direct radiative or IR heating from susceptor plates located on the opposite side of the tow from the waveguide opening for processing a band of multiple tows of fiber. It produces high-temperature-carbonized (HTC) fiber with shorter residence time and higher density compared to the conventional process. Its design is inherently scalable to larger production. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583847 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/328 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247622 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Jaswinder Singh (Dunlap, Illinois); Michael Bardell (Vail, Arizona); Yongxian Gu (West Lafayette, Indiana); Eric L. Schroeder (Germantown Hills, Illinois); Patrick J. Seiler (Peoria, Illinois) |
| ABSTRACT | A gaseous fuel engine system includes a hydrogen fuel supply, an engine housing having an intake port extending to a cylinder, and an intake runner. The intake runner includes a valve mount attached to a conduit and having a valve mounting face, and a gaseous fuel admission valve is mounted upon the valve mounting face. A hydrogen fuel passage extends from the valve mount through the conduit and is oriented angularly to at least one of a clamping face of the intake runner or the valve mounting face. Related apparatus and methodology is also disclosed. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100009 |
| CURRENT CPC | Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 21/023 (20130101) F02M 21/0206 (20130101) F02M 21/0278 (20130101) F02M 21/0281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247816 | Poerschke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RHEIA, LLC (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Poerschke (Pittsburgh, Pennsylvania); Anthony Grisolia (West Leechburg, Pennsylvania); Robert Beach (Pittsburgh, Pennsylvania) |
| ABSTRACT | An indoor environmental control and air distribution system for a building includes: an air handling unit; a manifold connected to the air handling unit having a chamber formed by a plurality of walls and a plurality of orifices formed through at least one of the walls; air distribution conduits each independently having a first end connected to the orifices of the manifold and a second end extending out from the manifold into different zones throughout the building; and an airflow modulating device having one or more airflow regulating dampers independently configured to move into at least two positions in which each position provides a different percentage of total air volume to each air distribution conduit. A method of using the indoor environmental control and air distribution system is also included. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585492 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 3/044 (20130101) Original (OR) Class F24F 13/10 (20130101) F24F 13/14 (20130101) F24F 13/105 (20130101) F24F 2110/10 (20180101) F24F 2110/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248037 | Deblonde et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gauthier Deblonde (San Ramon, California); Annie B. Kersting (Oakland, California); Mavrik Zavarin (Oakland, California) |
| ABSTRACT | This disclosure provides compositions comprising a light-harvesting molecule capable of producing luminescence upon interaction with a rare earth element or an actinide element, and a buffer, as well as assay systems, kits, and methods of detecting the presence of rare earth elements and/or actinide elements. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/097177 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248105 | Pracheil et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caroline Carter (Plano, Texas); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenda M. Pracheil (Knoxville, Tennessee); Phillip C. Chesser (Knoxville, Tennessee); Natalie A. Griffiths (Knoxville, Tennessee); Kristine Moody (Knoxville, Tennessee); Brian K. Post (Knoxville, Tennessee); Brennan T. Smith (Knoxville, Tennessee); Peter Wang (Oak Ridge, Tennessee); Caroline Carter (Plano, Texas); Celeste Atkins (Knoxville, Tennessee) |
| ABSTRACT | Systems and methods for operating an aquatic robot. The methods comprise: autonomously propelling the aquatic robot through a body of water to a location where a water sample is to be obtained; and performing operations by the aquatic robot to autonomously collect the water sample, cause the water sample to flow through a filter that retains eDNA, lyses and releases the eDNA to a create a lysate, process the lysate to obtain a product for eDNA sequencing, generate eDNA sequencing data using the product, and communicate the eDNA sequencing data to a remote external device. |
| FILED | Friday, September 29, 2023 |
| APPL NO | 18/374953 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 35/0099 (20130101) Original (OR) Class G01N 35/00871 (20130101) G01N 2001/1031 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248146 | Christophersen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon P. Christophersen (Moscow, Idaho); John L. Morrison (Butte, Montana); William H. Morrison (Butte, Montana) |
| ABSTRACT | Impedance testing system and methods are disclosed. A method may include applying a excitation signal to a device under a load condition and capturing a time record of an electrical signal from the device. The method may also include adjusting the time record based on an estimated response to the load condition and estimating an impedance of the device based on the adjusted time record. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623689 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/389 (20190101) Original (OR) Class G01R 31/392 (20190101) G01R 31/3648 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/48 (20130101) H01M 10/482 (20130101) H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248846 | Walker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean E. Walker (Allen, Texas); Tony M. Brewer (Plano, Texas) |
| ABSTRACT | System and techniques for recall pending cache line eviction are described herein. A queue that includes a deferred memory request is kept for a cache line. Metadata for the queue is stored in a cache line tag. When a recall is needed, the metadata is written from the tag to a first recall storage, referenced by a memory request ID. After the recall request is transmitted, the memory request ID is written to a second recall storage referenced by the message ID of the recall request. Upon receipt of a response to the recall request, the queue for the cache line can be restored by using the message ID in the response to lookup the memory request ID from the second recall storage, then using the memory request ID to lookup the metadata from the first recall storage, and then writing the metadata into the tag for the cache line. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591718 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0855 (20130101) Original (OR) Class G06F 12/0891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249042 | Rackauckas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JuliaHub, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rackauckas (Cambridge, Massachusetts); Viral B. Shah (Cambridge, Massachusetts); Yingbo Ma (Newton, Massachusetts) |
| ABSTRACT | Methods, systems, and computing devices of a solver for detecting discontinuities or irregularities in a simulation in scientific computing is disclosed. The solver detects a discontinuity or irregularity using two phases: a crude phase, and a fine phase. The crude phase determines an estimate of where the discontinuity is located by extrapolating the interpolant. The fine phase iteratively refines the location of the discontinuity using root-finding and simplified Newton iterations. The solver disclosed herein takes fewer steps when running a simulation because it accurately steps over the discontinuities. |
| FILED | Friday, March 15, 2024 |
| APPL NO | 18/606394 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249111 | Blake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert C. Blake (Mountain House, California); Thomas J. O'Hara (Alameda, California); Mikel L. Landajuela (Dublin, California); Rushil Anirudh (Dublin, California) |
| ABSTRACT | A computer-based system and process are disclosed for reconstructing the internal electrical behavior of a patient's heart based partly or wholly on the patient's electrocardiogram (ECG). The output of the process may include, for example, a cardiac activation map, and/or a representation of transmembrane potentials over time. The process advantageously does not require any medical imaging of the patient, and does not require any special medical equipment. For example, the patient's activation map and transmembrane potentials may be reconstructed based solely on a preexisting or newly-obtained 12-lead cardiac ECG of the patient. The process makes use of a machine learning model, such as a neural network based model, trained with actual and/or simulated ECGs and intracardiac electrical data (typically transmembrane potentials) of many thousands of patients. Because an insufficient quantity of such data exists for actual patients, model training may be performed using ECGs and intracardiac electrical data obtained through computer simulations. |
| FILED | Tuesday, April 02, 2024 |
| APPL NO | 18/624576 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/327 (20210101) A61B 5/367 (20210101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249891 | Brambilla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FastCAP Systems Corporation (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolo Michele Brambilla (Boston, Massachusetts); Fabrizio Martini (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is electrode comprising a current collector comprising a conductor layer having at least a first surface; and elongated metal carbide nanostructures extending from the first surface; and a carbonaceous energy storage media disposed on the first surface and in contact with the elongated metal carbide nanostructures. Disclosed herein too is an ultracapacitor comprising at least one electrode comprising a current collector comprising a conductor layer having at least a first surface; and elongated metal carbide nanostructures extending from the first surface; and a carbonaceous energy storage media disposed on the first surface and in contact with the elongated metal carbide nanostructures. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591573 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/158 (20170801) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/26 (20130101) H01G 11/28 (20130101) H01G 11/36 (20130101) Original (OR) Class H01G 11/46 (20130101) H01G 11/48 (20130101) H01G 11/70 (20130101) H01G 11/86 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250289 | Xiao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| ASSIGNEE(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan) |
| INVENTOR(S) | Xingcheng Xiao (Troy, Michigan) |
| ABSTRACT | A method to create a battery cell is provided. The method includes, within a vacuum or an inert atmosphere, utilizing an etching process to remove a passivation layer from a primary surface of a solid electrolyte. The method further includes applying a surface coating to the primary surface. The method further includes, within the battery cell, disposing the solid electrolyte including the surface coating between an anode and a cathode. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158719 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 10/0585 (20130101) H01M 2220/20 (20130101) H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250302 | Bocharova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vera Bocharova (Knoxville, Tennessee); Seung Pyo Jeong (Dublin, California); Xi Chen (Knoxville, Tennessee); Andrew S. Westover (Knoxville, Tennessee) |
| ABSTRACT | A hairy nanoparticle (HNP) composition comprising: (i) a nanoparticle core; and (ii) an ion-conductive polymer chemically attached to the nanoparticle core, wherein the ion-conductive polymer is either polyanionic with mobile cations or polycationic with mobile anions. Also described herein is a method for producing the HNP composition, electrolytes containing the HNP composition incorporated therein, and batteries (e.g., metal and metal-ion, such as lithium ion batteries) containing electrolytes (e.g., solid, gel, or liquid) in which the HNP composition has been incorporated. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378373 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) H01M 10/0565 (20130101) H01M 10/0567 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250491 | Payne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen A. Payne (Castro Valley, California); Nerine J. Cherepy (Piedmont, California); Eric B. Duoss (Dublin, California); Ivy Krystal Jones (Chicago, Illinois); Zachary M. Seeley (Livermore, California); Cheng Zhu (Livermore, California) |
| ABSTRACT | In one aspect, a transparent ceramic optic includes: a lasing region comprising at least one lasing species dopant; and a transparent region transparent to light generated by the lasing species. At least the transparent region is doped with at least one other dopant species such that the lasing region and the transparent region are characterized by a difference in refractive index between the two regions in an amount of about 1.0×10−4 or less. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623965 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/113 (20130101) H01S 3/0617 (20130101) Original (OR) Class H01S 3/0912 (20130101) H01S 3/0941 (20130101) H01S 3/1643 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250568 | Simizu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Satoru Simizu (Pittsburgh, Pennsylvania); Paul Richard Ohodnicki, Jr. (Allison Park, Pennsylvania); Michael Edward McHenry (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided is an axial flux motor including a rotor having a wound ribbon core, the wound ribbon core including a metal amorphous nanocomposite material. The axial flux motor further includes a stator assembly spaced apart from the rotor along a rotation axis of the rotor. The stator assembly includes a body including a metal amorphous nanocomposite material and a plurality of permanent magnets substantially free of rare-earth materials. The plurality of permanent magnets is arranged on the body of the stator assembly. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442783 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/02 (20130101) H02K 1/2796 (20220101) Original (OR) Class H02K 3/12 (20130101) H02K 19/10 (20130101) H02K 21/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240251013 | KWAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHIMAN KWAN (ROCKVILLE, Maryland) |
| ABSTRACT | The present invention describes a dense radiation map generation system using radiation detection sensors with advanced signal processing algorithms. Only a small number of detectors is needed, and yet dense radiation maps can be generated via signal processing algorithms. The detectors are wirelessly connected to a data processing center. The present invention utilizes an integrated system for dense radiation map generation, making it feasible to low cost and real-time radiation monitoring. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099655 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2921 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) Original (OR) Class Wireless Communication Networks H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240251576 | Hammond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); SolarWindow Technologies, Inc. (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Hammond (Wheat Ridge, Colorado); Marinus Franciscus Antonius Maria van Hest (Golden, Colorado) |
| ABSTRACT | Systems and methods for organic semiconductor devices with sputtered contact layers are provided. In one embodiment, an organic semiconductor device comprises: a first contact layer comprising a first sputter-deposited transparent conducting oxide; an electron transport layer interfacing with the first contact layer; a second contact layer comprising a second sputter-deposited transparent conducting oxide; a hole transport layer interfacing with the second contact layer; and an organic semiconductor active layer having a first side facing the electron transport layer and an opposing second side facing the hole transport layer; wherein either the electron transport layer or the hole transport layer comprises a buffering transport layer. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/351880 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/82 (20230201) Original (OR) Class H10K 50/11 (20230201) H10K 50/15 (20230201) H10K 50/16 (20230201) H10K 50/816 (20230201) H10K 50/828 (20230201) H10K 71/16 (20230201) H10K 71/60 (20230201) H10K 2102/101 (20230201) H10K 2102/103 (20230201) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240246072 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GeneCapture, Inc. (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Greg Thompson (Scottsboro, Alabama); Zachary McGee (Huntsville, Alabama); Paula Millirons (Owens Cross Roads, Alabama) |
| ABSTRACT | Integrated cartridges for sample homogenization, nucleic acid fragmentation, and nucleic acid detection are disclosed herein. The integrated cartridges include a main housing having a sample well and a detection chamber and a sonication feature coupled to and extending outwardly from the main housing. The sonication feature includes a sonication chamber for receiving a sample fluid. A fluidic path directs the sample fluid from the sample well, to the sonication chamber, and to the detection chamber. Systems for use with the integrated cartridges can include sonotrodes with openings for positioning the sonication feature and/or temperature sensors for monitoring the temperature of the sonication feature. Methods include moving the sample fluid from the sample well to the sonication feature, transmitting ultrasonic energy into the sample fluid, moving the sample fluid from the sonication feature to the detection chamber, and performing a nucleic acid detection assay within the detection chamber. |
| FILED | Monday, January 29, 2024 |
| APPL NO | 18/425316 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 2200/147 (20130101) B01L 2300/0663 (20130101) B01L 2300/1805 (20130101) B01L 2300/1894 (20130101) B01L 2400/0436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246075 | Amassian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Aram Amassian (Raleigh, North Carolina); Nathaniel R. Woodward (Raleigh, North Carolina); Mihirsinh Chauhan (Raleigh, North Carolina); Boyu Guo (Raleigh, North Carolina) |
| ABSTRACT | Devices, systems, and methods for characterizing material samples. In one aspect, a device for characterizing a sample includes a substrate configured for receiving a sample thereon; an optical fiber probe comprising a first end positioned near the sample and a second end that is bifurcated to include one or more first fiber configured for connection to a first light emitting device and one or more second fiber configured for connection to a spectrometer; a reflectance module coupled to the substrate; and a second light emitting device positioned near the sample. The optical fiber probe is configured for selectively obtaining at the spectrometer both a reflectance absorbance measurement of the sample associated with the first light emitting device and a photoluminescence measurement of the sample associated with the second light emitting device. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236226 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/168 (20130101) B01L 2300/0609 (20130101) B01L 2300/0654 (20130101) B01L 2300/0851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246327 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. Cooper (Palo Alto, California); Zhenan Bao (Stanford, California); Samuel E. Root (Stanford, California) |
| ABSTRACT | In certain examples, methods and devices, such as a soft electronics device, involve or include a first layer and a second layer from among the plurality of immiscible polymer layers, with the first and second layers integrated with one another to form a multilayered self-healing laminate, characterized in that polymer material in the first layer and polymer material in the second layer are cooperatively capable of autonomously recovering from at least one of the first layer and second layer being misaligned. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/418077 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/06 (20130101) B32B 33/00 (20130101) Original (OR) Class B32B 2307/762 (20130101) B32B 2457/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246471 | Sura et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | USA as represented by the Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Daniel A. Sura (San Diego, California); Michael R. Koppi, JR. (San Diego, California); Colin J. Fera (San Diego, California); Gary L. Davis (San Diego, California) |
| ABSTRACT | The invention disclosed herein include system, kit and method embodiments for transportation, launch and recovery of large watercraft, particularly large unmanned underwater vehicles (UUVs). Features of the system and kit embodiments may include, but are not limited to guide rails with guide wheels mounted to the open end of a marine trailer that may be fixed or rotating between an open V-shaped position for guiding the watercraft during launch and recovery and a closed parallel position when loaded and during transportation, mounting adapter assemblies that allow the guide rails to tilt vertically to compensate for boat ramp gradient and cable guide posts for maintaining the tow cable within the open end of the trailer during launch and recovery. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/157269 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 3/1066 (20130101) Original (OR) Class B60P 3/1075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246623 | Blankespoor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Blankespoor (Arlington, Massachusetts); Alex Perkins (Arlington, Massachusetts); Marco da Silva (Arlington, Massachusetts) |
| ABSTRACT | An example method may include i) determining a first distance between a pair of feet of a robot at a first time, where the pair of feet is in contact with a ground surface; ii) determining a second distance between the pair of feet of the robot at a second time, where the pair of feet remains in contact with the ground surface from the first time to the second time; iii) comparing a difference between the determined first and second distances to a threshold difference; iv) determining that the difference between determined first and second distances exceeds the threshold difference; and v) based on the determination that the difference between the determined first and second distances exceeds the threshold difference, causing the robot to react. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587680 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1633 (20130101) B25J 9/1653 (20130101) B25J 9/1694 (20130101) B25J 13/08 (20130101) B25J 13/085 (20130101) Motor Vehicles; Trailers B62D 57/02 (20130101) Original (OR) Class B62D 57/032 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246688 | Heeter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Heeter (Indianapolis, Indiana); Daniel E. Molnar, JR. (Indianapolis, Indiana); Kathryn A. Sontag (Indianapolis, Indiana); Michael G. Meyer (Indianapolis, Indiana) |
| ABSTRACT | An aircraft includes a duct system configured to receive a flow of air therethrough and a gas turbine engine. The duct system includes a main duct and inlet ducts arranged fluidly upstream of the main duct so as to conduct the flow of air from the inlet ducts into the main duct. The gas turbine engine in downstream fluid communication with the main duct. |
| FILED | Wednesday, January 25, 2023 |
| APPL NO | 18/101567 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/02 (20130101) Original (OR) Class B64D 2033/0226 (20130101) B64D 2033/0286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246869 | SAMBASIVAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | APPLIED THIN FILMS, INC. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankar SAMBASIVAN (Chicago, Illinois); Vikram S. KAUL (Atlanta, Georgia); Francis R. CHAPMAN (Chicago, Illinois) |
| ABSTRACT | A material contains open pores in which the channels and pores that are internally coated with at least one layer of phosphorus-containing alumina. Such material is formed by infiltrating a porous material one or more times with a non-colloidal, low-viscosity liquid coating precursor, drying, and curing the coating precursor to form a phosphorus-containing alumina layer within pores of the material. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588182 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/195 (20130101) C04B 35/522 (20130101) C04B 38/0054 (20130101) C04B 38/0096 (20130101) Original (OR) Class C04B 41/009 (20130101) C04B 41/85 (20130101) C04B 41/5092 (20130101) C04B 2235/3206 (20130101) C04B 2235/3208 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/125 (20130101) C23C 18/1216 (20130101) C23C 18/1229 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/514 (20130101) F05D 2300/6033 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/268 (20150115) Y10T 428/24997 (20150401) Y10T 428/249921 (20150401) Y10T 428/249967 (20150401) Y10T 428/249969 (20150401) Y10T 428/249978 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247086 | ANNAPOORANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raja ANNAPOORANAN (San Diego, California); Yang WANG (San Diego, California); Shengqiang CAI (San Diego, California) |
| ABSTRACT | Described are methods for manufacturing and using an electromechanical soft actuator including a dielectric liquid crystal elastomer. A method for manufacturing the electromechanical soft actuator including the dielectric liquid elastomer may include the steps of fabricating a loosely cross-linked polydomain liquid crystal elastomer, pre-stretching the loosely cross-linked polydomain liquid crystal elastomer on a frame, cross-linking elements of the loosely cross-linked polydomain liquid crystal elastomer to form the dielectric liquid crystal elastomer and removing the frame from the dielectric liquid crystal elastomer. The disclosed electromechanical soft actuator including the dielectric liquid crystal elastomer can be used in transducer for converting electrical energy to mechanical energy. The transducer may include at least two electrodes, and the dielectric liquid crystal elastomer, which has a first position that is deflected to a second position in response to a change in an electric field provided by the at least two electrodes. |
| FILED | Friday, October 06, 2023 |
| APPL NO | 18/482471 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 22/20 (20130101) Original (OR) Class Electric Machines Not Otherwise Provided for H02N 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247247 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem ISMAGILOV (Altadena, California); Erik JUE (Pasadena, California); Daan WITTERS (San Diego, California) |
| ABSTRACT | A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis. |
| FILED | Wednesday, September 20, 2023 |
| APPL NO | 18/470879 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/508 (20130101) B01L 3/50851 (20130101) B01L 3/502753 (20130101) B01L 7/52 (20130101) B01L 2200/0631 (20130101) B01L 2200/0689 (20130101) B01L 2300/04 (20130101) B01L 2300/18 (20130101) B01L 2300/069 (20130101) B01L 2300/0672 (20130101) B01L 2400/0605 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class C12N 15/1006 (20130101) C12N 15/1013 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247249 | FUNKNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac Manufacturing GmbH (Tübingen, Germany) |
| INVENTOR(S) | Andreas FUNKNER (Tübingen, Germany); Stefanie DORNER (Tübingen, Germany); Stefanie SEWING (Tübingen, Germany); Johannes KAMM (Tübingen, Germany); Norbert BROGHAMMER (Tübingen, Germany); Thomas KETTERER (Gomaringen, Germany); Thorsten MUTZKE (Reutlingen, Germany) |
| ABSTRACT | The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA: transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF). |
| FILED | Monday, October 23, 2023 |
| APPL NO | 18/491943 |
| CURRENT CPC | Separation B01D 61/145 (20130101) B01D 71/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247933 | Ekholm |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K Ekholm (Falmouth, Massachusetts) |
| ABSTRACT | A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/600019 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248077 | Ingber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Geraldine A. Hamilton (Cambridge, Massachusetts); Bryan Hassell (Cambridge, Massachusetts); Christopher D. Hinojosa (Cambridge, Massachusetts); Carolina Lucchesi (Westwood, Massachusetts) |
| ABSTRACT | Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436701 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 25/02 (20130101) C12M 35/04 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) Original (OR) Class G01N 2800/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248366 | Cho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang-Yen Cho (Columbia, Maryland); Weimin Zhou (Rockville, Maryland) |
| ABSTRACT | An optoelectronic device apparatus using active, frequency-selective metasurfaces to achieve retroreflection at a pre-determined single frequency and optionally provide signal modulation on the reflected light beam. The apparatus may use several active, frequency-selective metasurfaces to replace traditional optical lens and mirrors. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099278 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/19 (20130101) Original (OR) Class G02F 2202/30 (20130101) G02F 2203/15 (20130101) Transmission H04B 10/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248368 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Peng Yu (Boulder, Colorado); Scott B. Papp (Boulder, Colorado) |
| ABSTRACT | A photonic-crystal resonator (PhCR) and associated methods of design and manufacture. The PhCR includes spontaneous optical-pulse generation and includes a ring whose geometry is correlated to a mode structure or dispersion of the PhCR while also taking into account a desired type of nonlinear optical output from the PhCR, such as an optical frequency comb, or a particular type of pulse. The PhCR includes a periodic nanopatterning on an inner radial wall of its ring and is able to spontaneously generate a nonlinear optical output. The nanopatterning of the inner radial wall is designed to form a desired output, such as one of a classic soliton pulse that has a sech type temporal profile, or a gaussian profile, or a sink pulse profile. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/648913 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249050 | Kimura et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Kimura (Lewis Center, Ohio); Rohan Prabhu (Dublin, Ohio); Noah Mun (Columbus, Ohio) |
| ABSTRACT | In an integrated circuit (IC) assessment method, an artificial intelligence (AI) component comprising at least one artificial neural network (ANN) is trained to transform layout rendering tiles of a rendering of a reference IC into corresponding reference layout image tiles extracted from at least one layout image of the reference IC. Using the trained AI component, standard cell layout renderings of a library of GDSII or OASIS standard cell layout renderings are transformed into as-fabricated standard cell layout renderings forming a library of as fabricated standard cell layout renderings. Instantiated standard cells and their placements in the layout image of an IC-under-test are identified by matching the instantiated standard cells with corresponding as-fabricated standard cell layout renderings retrieved from the library of as fabricated standard cell layout renderings. |
| FILED | Tuesday, January 09, 2024 |
| APPL NO | 18/408018 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) G06F 30/327 (20200101) Original (OR) Class G06F 30/333 (20200101) G06F 30/367 (20200101) G06F 30/392 (20200101) G06F 30/398 (20200101) G06F 30/3308 (20200101) G06F 2119/18 (20200101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249123 | SARAGADAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Vishwanath Raja Venkata SARAGADAM (Houston, Texas); Randall BALESTRIERO (Houston, Texas); Ashok VEERARAGHAVAN (Houston, Texas); Richard BARANIUK (Houston, Texas) |
| ABSTRACT | A method and a system for a computationally efficient framework for low-rank decomposition of matrices and tensors using neural generative networks is disclosed. The method includes decomposing a tensor into a plurality of low-rank tensor factors and generating each low-rank tensor factor by a corresponding neural network. Further, the method includes feeding each neural network with a corresponding plurality of input tensors. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182924 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0475 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249139 | Bihl et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Bihl (Wheelersburg, Ohio); Anthony Baietto (Columbus, Ohio); Aaron Jones (Oakwood, Ohio); Jayson Boubin (Endwelly, New York) |
| ABSTRACT | A method of analyzing and correcting a complex dynamic waveform, such as a radar wave or communication wave. The method comprises developing a loss function as the difference the actual characteristics and desired characteristics of the mean squared error and at least one of frequency-domain power, time-domain envelope, and frequency-domain phase. These differences are fed into a neural network to improve prediction correction to bring the actual waveform closer to a benchmark waveform. The method of the present invention displays increased accuracy over the prior art without increased computing time or sacrificing notch depth. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/418576 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249498 | Galeotti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Michael Galeotti (Pittsburgh, Pennsylvania); Gautam Rajendrakumar Gare (Pittsburgh, Pennsylvania); Ricardo Luis Rodriguez (Baltimore, Maryland); Bennett DeBoisblanc (New Orleans, Louisiana) |
| ABSTRACT | Provided are systems, methods, and computer program products for extracting features from imaging biomarkers with machine-learning models. The method includes training a first artificial intelligence (AI) model based on first training data including images labeled with imaging biomarkers, the first AI model trained to identify a plurality of imaging biomarker features in at least one image, training a second AI model based on second training data including sets of imaging biomarker features associated with task-specific labels, the second AI model trained to identify at least one task-specific feature based at least partially on a set of imaging biomarker features, processing at least one input image with the first AI model to generate a first AI model output, and processing the first AI model output with the second AI model to generate a second AI model output. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/289588 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10132 (20130101) G06T 2207/20081 (20130101) G06T 2207/30061 (20130101) Image or Video Recognition or Understanding G06V 10/44 (20220101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249954 | KALARICKAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nidhin Kurian KALARICKAL (Columbus, Ohio); Andreas Fiedler (Columbus, Ohio); Siddharth Rajan (Columbus, Ohio) |
| ABSTRACT | A method for using gallium beam flux in an ultra-low vacuum environment to etch Ga2O3 epilayer surfaces is provided. An Ga2O3 epilayer surface (105) is patterned by applying a SiO2 mask (107) that corresponds to a desired structure (810). The patterned surface is then placed in an ultra-low vacuum environment (130) and is heated to a very high temperature (820; 830). At the same time, a gallium flux is supplied to the patterned surface in the ultra-low vacuum environment (840). The gallium flux causes etching in the patterned surface that is not covered by the SiO2 mask. Using this method, sub-micron (˜100 nm) three-dimensional (3D) structures like fins, trenches, and nano-pillars can be fabricated with vertical sidewalls. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 18/560422 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/3081 (20130101) H01L 21/31116 (20130101) H01L 21/31144 (20130101) Original (OR) Class H01L 21/823431 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250288 | KOSYAKOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATRION INC. (ALBANY, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALEXANDER KOSYAKOV (Champaign, Illinois); SOHEIL MALEKPOUR (Champaign, Illinois); DIPOBRATO SARBAPALLI (Brunswick, Ohio); DAH-SHYANG TSAI (Champaign, Illinois); DUKE PO-CHEN SHIH (Mankato, Minnesota); DILLON GRANT (Champaign, Illinois); GAVIN DEPEW (Champaign, Illinois); BRUCE KRAAY (Apex, North Carolina) |
| ABSTRACT | The disclosure relates to a composite solid electrolyte (CSE) for a battery in various formats including a freestanding CSE separator, electrode-CSE laminate, current collector-CSE laminate, or CSE-based mixed ionic-electronic conductor (MIEC) electrode. The disclosure also relates to the methods of making composite solid electrolytes and batteries therewith. A CSE is disclosed having at least one polymer; at least one lithium salt; a solvent plasticizer; at least one inorganic additive particle; a substrate; and one or more liquid or solid additives. A method of making a CSE is disclosed as providing, as a liquid slurry, at least one polymer, at least one lithium salt, a solvent plasticizer, at least one inorganic additive particle, and one or more liquid or solid additives and coating a substrate with the liquid slurry. |
| FILED | Wednesday, October 25, 2023 |
| APPL NO | 18/494069 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/661 (20130101) H01M 10/056 (20130101) Original (OR) Class H01M 10/4235 (20130101) H01M 2300/0071 (20130101) H01M 2300/0082 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250543 | Harris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher A. Harris (Falls Church, Virginia); Jeffrey A. Knowles (Yorba Linda, California) |
| ABSTRACT | An electric propulsion power system a power plant providing power to a bus, a load drawing power from the bus, a battery providing power to and drawing power from the bus. The power system also includes a control system for controlling the amount of power that the power plant provides to the bus, the amount of power that the battery provides to and draws from the bus in response to the load drawing power from the bus over time. The control system calculates a moving time-average current value over a predetermined time window using the instantaneous current measurements, determines a delta current value as the difference between a current charge/discharge limit of the battery and the moving time-average current value and determines if additional power from the power plant to the bus will be provided and a rate of current in the discharge mode or the charge mode. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/158200 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0047 (20130101) Original (OR) Class H02J 7/00714 (20200101) H02J 7/007182 (20200101) H02J 2310/44 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250745 | GANDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Minds, LLC (Burbank, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles L. GANDY (Annapolis, Maryland); Clinton Blake HOPE (Los Angeles, California); Edward Francis ADAMS (Los Angeles, California); Donald Gregory LARIVIERE (Glendale, California); Houstin L. LICHTENWALNER (Macungie, Pennsylvania) |
| ABSTRACT | Disclosed are passive reflector radio communications systems, such as for UHF frequencies or greater than UHF frequencies, and related deployment systems and devices that provide underground communications. Embodiments of the system include reflector elements to provide passive radio communications, structural frameworks to support and orient the reflector elements, methods for calculating reflector size, shape, and position corresponding to a desired wavelength, and deployment methods and devices to install the communication system at a desired location. The passive reflectors can be placed in a folded or otherwise compact mode, for transport into underground tunnels. Once at the desired installation location, the system can be installed, with the reflectors positioned appropriately for the radio frequencies used at the location. Some of the embodiments include any of vertical or horizontal foldable reflector poles, reflective sheets, reflective mesh sheets and/or ropes, inflatable reflective pucks, and rapid deployment systems and methods. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/593150 |
| CURRENT CPC | Transmission H04B 7/145 (20130101) Original (OR) Class H04B 7/15507 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240251681 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Matthew Johnson (Springville, Indiana); William Riggins (Bloomington, Indiana); Scott L. Small (Newberry, Indiana) |
| ABSTRACT | Provided is a fixture for concentrically aligning and assembling a Ceramic Stack Assembly transducer during manufacturing. The CSA fixture comprises a base, a top compression cap, a central rod and a fastener, one or more alignment posts, and a driving wedge. The base further includes a groove to accept and align a transducer rear-centering ring at a central axis of the fixture. The transducer rear-centering ring supports one or more copper foil or ceramic rings during assembly. The alignment posts and driving wedge apply radial pressure to the copper foil or ceramic rings during assembly to force concentric alignment. The top compression cap, central rod, and fastener compress and stress the CSA Ceramic once assembled. The fixture simultaneously provides concentric alignment, foil alignment and provides a mechanism for stressing the CSA. A method of use is also provided. |
| FILED | Friday, December 22, 2023 |
| APPL NO | 18/394433 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0611 (20130101) B06B 2201/74 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/10 (20130101) B32B 37/0046 (20130101) B32B 2311/12 (20130101) B32B 2315/02 (20130101) B32B 2457/00 (20130101) Electric solid-state devices not otherwise provided for H10N 30/057 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240245307 | BRANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly BRANAN (College Station, Texas); Cody LEWIS (College Station, Texas); Richard HORNER (College Station, Texas); Gerard L. COTE (College Station, Texas); Darpit DAVE (College Station, Texas); Kathan VYAS (College Station, Texas); Madhav ERRAGUNTLA (College Station, Texas); Ricardo GUTIERREZ-OSUNA (College Station, Texas); Justin MCMURRAY (College Station, Texas) |
| ABSTRACT | A wearable multi-sensor device for measuring physiological properties includes a plurality of non-invasive sensors, such as a single-sided electrocardiography sensor, a bioimpedance and electrodermal activity sensor, a skin temperature sensor, and a photoplethysmography sensor. The device is configured to secure a skin-facing side of the sensors to exposed skin of a user and includes a communication module configured to receive signals from the plurality of non-invasive sensors and output data from the device, the being suitable for use in predicting glycemic events in the user. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/418861 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/08 (20130101) A61B 5/11 (20130101) A61B 5/282 (20210101) A61B 5/0295 (20130101) A61B 5/346 (20210101) A61B 5/0533 (20130101) A61B 5/02055 (20130101) Original (OR) Class A61B 5/6824 (20130101) A61B 5/7235 (20130101) A61B 5/7275 (20130101) A61B 5/7282 (20130101) A61B 2562/0219 (20130101) A61B 2562/0233 (20130101) A61B 2562/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245787 | Woo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Christina M. Woo (Cambridge, Massachusetts); Saki Ichikawa (Cambridge, Massachusetts); Hope Airlie Flaxman (Cambridge, Massachusetts); Wengqing Xu (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates to compounds of Formula (I′) and Formula (I), and pharmaceutically acceptable salts or tautomers thereof. Also disclosed are compositions, combination therapies, kits, uses, and methods. Exemplary uses include treating diseases and disorders including cancers (e.g., hemopoietic cancers (e.g., leukemia, lymphoma, multiple myeloma)), inflammatory diseases (e.g., erythema nodosum leprosum, arthritis, Crohn's disease, colitis, inflammatory bowel disease), and autoimmune diseases (e.g., pulmonary fibrosis, systemic lupus erythematosus). |
| FILED | Wednesday, April 13, 2022 |
| APPL NO | 18/286740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class A61K 47/542 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245828 | Van Belleghem et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Sarah Van Belleghem (Washington, District of Columbia); John Patrick Fisher (Kensington, Maryland) |
| ABSTRACT | An implantable scaffold device comprises a non-biodegradable backbone and a biodegradable dermal compartment comprising live cells. Method of fabricating implantable devices via 3D printing using a synthetic ink formulation coprinted with a biodegradable bioink. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391766 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3641 (20130101) A61L 27/3813 (20130101) A61L 2300/41 (20130101) A61L 2300/406 (20130101) A61L 2300/414 (20130101) A61L 2430/34 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0061 (20130101) B29K 2995/0056 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7532 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246036 | CUI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Honggang CUI (Lutherville-Timonium, Maryland); Boran SUN (Baltimore, Maryland); Michael J. BETENBAUGH (Baltimore, Maryland); David STERN (Baltimore, Maryland) |
| ABSTRACT | Provided herein are antifouling filtration membranes that include a membrane substrate and an antifouling coating disposed on at least one surface of the membrane substrate. The antifouling coating comprises a plurality of zwitterionic molecules or moieties at a density sufficient to form a hydration shell when an aqueous input composition contacts the antifouling coating. The hydration shell substantially prevents fouling components in the aqueous input composition from adsorbing on the membrane substrate while substantially permitting target permeate molecules in the aqueous input composition to flow through the membrane substrate. Additional methods and related devices, systems, and kits are also provided. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413529 |
| CURRENT CPC | Separation B01D 65/08 (20130101) Original (OR) Class B01D 69/12 (20130101) B01D 71/68 (20130101) B01D 2311/2523 (20220801) B01D 2325/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246075 | Amassian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Aram Amassian (Raleigh, North Carolina); Nathaniel R. Woodward (Raleigh, North Carolina); Mihirsinh Chauhan (Raleigh, North Carolina); Boyu Guo (Raleigh, North Carolina) |
| ABSTRACT | Devices, systems, and methods for characterizing material samples. In one aspect, a device for characterizing a sample includes a substrate configured for receiving a sample thereon; an optical fiber probe comprising a first end positioned near the sample and a second end that is bifurcated to include one or more first fiber configured for connection to a first light emitting device and one or more second fiber configured for connection to a spectrometer; a reflectance module coupled to the substrate; and a second light emitting device positioned near the sample. The optical fiber probe is configured for selectively obtaining at the spectrometer both a reflectance absorbance measurement of the sample associated with the first light emitting device and a photoluminescence measurement of the sample associated with the second light emitting device. |
| FILED | Monday, August 21, 2023 |
| APPL NO | 18/236226 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/168 (20130101) B01L 2300/0609 (20130101) B01L 2300/0654 (20130101) B01L 2300/0851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246143 | Niauzorau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stanislau Niauzorau (Gilbert, Arizona); Aliaksandr Sharstniou (Gilbert, Arizona); Amm G. Hasib (Chandler, Arizona); Bruno Azeredo (Scottsdale, Arizona); Natalya Kublik (Tempe, Arizona); Kenan Song (Athens, Georgia); Nikhilesh Chawla (West Lafayette, Indiana); Sridhar Niverty (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanislau Niauzorau (Gilbert, Arizona); Aliaksandr Sharstniou (Gilbert, Arizona); Amm G. Hasib (Chandler, Arizona); Bruno Azeredo (Scottsdale, Arizona); Natalya Kublik (Tempe, Arizona); Kenan Song (Athens, Georgia); Nikhilesh Chawla (West Lafayette, Indiana); Sridhar Niverty (West Lafayette, Indiana) |
| ABSTRACT | A method of making a metal-polymer composite includes dealloying metallic powder to yield porous metal particles, monitoring a temperature of the mixture, controlling the rate of combining, a maximum temperature of the mixture, or both, and combining the porous metal particles with a polymer to yield a composite. Dealloying includes combining the metallic powder with an etchant to yield a mixture. A metal-polymer composite includes porous metal particles having an average particle size of about 0.2 μm to about 500 μm and a thermoplastic or thermoset polymer. The polymer composite comprises at least 10 vol % of the porous metal particles. A powder mixture includes porous metal particles having an average particle size of about 0.2 μm to about 500 μm and a metal powder. The powder mixture includes about 1 wt % to about 99 wt % of the porous metal particles. |
| FILED | Monday, April 08, 2024 |
| APPL NO | 18/628908 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) B22F 1/10 (20220101) Original (OR) Class B22F 1/145 (20220101) B22F 10/18 (20210101) B22F 2301/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246226 | Vikas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vishesh Vikas (Tuscaloosa, Alabama); Cole Woods (Tuscaloosa, Alabama) |
| ABSTRACT | Disclosed is a continuum manipulator that comprises of an assembly of ‘vertebra’-like modules fabricated using two curved links and twelve strings and actuated using Motor-Tendon Actuators. The modules being modeled as tensegrity structures having a polyhedron shape. The vertices and edges of the tensegrity structure polyhedron correspond to the holes and strings or links of the structure. Also disclosed is a mobile continuum manipulator that includes a control unit and wheels or mobile legs. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419095 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0009 (20130101) B25J 9/065 (20130101) Original (OR) Class B25J 9/1045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247216 | Kozbial |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FLASKWORKS, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kozbial (East Boston, Massachusetts) |
| ABSTRACT | A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/582765 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 23/34 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) C12M 41/00 (20130101) C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 2506/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247219 | Skerlos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Skerlos (Ann Arbor, Michigan); Lutgarde Raskin (Ann Arbor, Michigan); Timothy Fairley-Wax (Ann Arbor, Michigan); Nishant Jalgaonkar (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to the reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623416 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/10 (20130101) C02F 3/1268 (20130101) C02F 3/2806 (20130101) C02F 3/2853 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/06 (20130101) C12M 25/00 (20130101) C12M 27/14 (20130101) C12M 29/26 (20130101) Original (OR) Class C12M 33/14 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247228 | Whitaker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NOVOME BIOTECHNOLOGIES, INC. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weston Robert Whitaker (Daly City, California); William Cain DeLoache (Alameda, California); Zachary Nicholas Russ, IV (San Bruno, California); Elizabeth Joy Stanley Shepherd (Redwood City, California); Lauren Popov (Redwood City, California) |
| ABSTRACT | The present disclosure provides biocontainment methods and mechanisms that prevent modified cells from escaping their intended environment(s) while enabling the survival and replication of the modified cells where intended. This is achieved by linking the viability of the modified cells to the presence of a control molecule that is exogenously supplied to define the location and time in which cells are capable of growing. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/618130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 1/38 (20130101) C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247252 | Gao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Jianmin Gao (Newton, Massachusetts) |
| ABSTRACT | This patent document provides novel compounds as warheads for therapeutic or diagnostic agents. Advantages of the agents modified with the warheads include low off-target conjugation and minimized immunogenicity due to the reversible covalent bonding between the warheads and the targets. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405421 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Peptides C07K 7/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248028 | WOLF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian WOLF (Arlington, Virginia); Eryn NELSON (Washington, District of Columbia); Jeffrey S. S. K. FORMEN (Arlington, Virginia) |
| ABSTRACT | An analytical method is disclosed that includes the steps of: providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms; providing a probe selected from the group consisting of quinones and analogs thereof, (hetero)aryl isocyanates and analogs thereof, and (hetero)aryl isothiocyanates and analogs thereof; contacting the sample with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and determining, based on any binding that occurs, the absolute configuration of the analyte in the sample and/or the concentration of the analyte in the sample and/or the enantiomeric and/or the diastereomeric composition of the analyte in the sample. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 18/554405 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/19 (20130101) G01N 21/33 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248093 | Sulchek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Sulchek (Atlanta, Georgia); Ignacio Sanz (Atlanta, Georgia); Frances Eun-Hyung LEE (Atlanta, Georgia); Katily Ramirez (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a composition comprising a cell capable of secreting one or more molecules, the cell non-covalently attached to a particle, wherein the particle comprises a first linker linking a collector unit, the collector unit capable of binding to the one or more molecules secreted by the cell, optionally, wherein the one or more molecules secreted by the cell are bound to the first unit. The cell is non-covalently bound to the particle through a targeting unit affixed to the particle via a second linker. Also disclosed are methods of isolating cells with one or more particles comprising the same or different collector units and targeting units. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/289868 |
| CURRENT CPC | Peptides C07K 16/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249123 | SARAGADAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Vishwanath Raja Venkata SARAGADAM (Houston, Texas); Randall BALESTRIERO (Houston, Texas); Ashok VEERARAGHAVAN (Houston, Texas); Richard BARANIUK (Houston, Texas) |
| ABSTRACT | A method and a system for a computationally efficient framework for low-rank decomposition of matrices and tensors using neural generative networks is disclosed. The method includes decomposing a tensor into a plurality of low-rank tensor factors and generating each low-rank tensor factor by a corresponding neural network. Further, the method includes feeding each neural network with a corresponding plurality of input tensors. |
| FILED | Monday, March 13, 2023 |
| APPL NO | 18/182924 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0475 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249553 | BRANAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kimberly BRANAN (College Station, Texas); Gerard L. COTE (College Station, Texas); Justin MCMURRAY (College Station, Texas) |
| ABSTRACT | Wearable optical devices, methods and systems for obtain dynamic and static physiological parameters from a subject are disclosed. Example devices can be worn around an appendage, such as a finger, and utilize PPG sensors to obtain signals from the appendage. The PPG sensors are positioned to acquire signals suitable to reconstruct an image of the inner appendage using, for example, diffuse optical tomography, to provide additional information. The devices, methods, and systems can obtain dynamic and static physiological parameters and accurate images in real-time. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/418887 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) Image or Video Recognition or Understanding G06V 40/145 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250706 | Mansoorzare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hakhamanesh Mansoorzare (Orlando, Florida); Reza Abdolvand (Orlando, Florida) |
| ABSTRACT | Systems and devices for a self-interference cancelation scheme that allows for large numbers of delays while maintaining a small size and area. The main components of this scheme include AE delay line arrays (for re-constructing the interference to be subtracted); AE circulators (for providing isolation between the transmitter-to-antenna and antenna-to-receiver paths); and AE couplers (for tapping the signal from the transmit chain to the delay lines). Together, a fully micro-acoustic interference cancelation module is realized in thin-film piezoelectric-semiconductor heterostructures, which are usable in cellular communication devices, base stations, wireless communication modules, and similar transmission/reception systems. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/514389 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/423 (20130101) Transmission H04B 1/10 (20130101) H04B 1/0475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240250758 | Tao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Junliang Tao (Chandler, Arizona); Yi Zhong (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junliang Tao (Chandler, Arizona); Yi Zhong (Tempe, Arizona) |
| ABSTRACT | A system of communication using seismic wave creation and detection, and methods of use of the system are disclosed herein. A system of communication in a medium is applicable for underground applications, allowing the activation of drumming and vibrational sources to send seismic waves through a medium to communicate messages that are converted to binary code. A nearby receiver can detect the seismic waves and decode the data recorded in response to the seismic wave activity before decoding the message. This system of communication enables efficient communication in underground mediums. |
| FILED | Tuesday, January 23, 2024 |
| APPL NO | 18/419899 |
| CURRENT CPC | Transmission H04B 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240245244 | Colantonio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government As Represented By the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheryl L. Colantonio (Tampa, Florida); Bruce W. Burkhardt (Tampa, Florida) |
| ABSTRACT | An assembly can be configured to couple to an attachment structure. The assembly can comprise a cup holder having a top opening and defining an interior that is configured to receive and hold at least a portion of a cup. A bracket can be pivotably coupled to the cup holder about a horizontal axis so that the top opening faces upwardly. The bracket can comprise a coupling structure that is configured to couple to an attachment structure. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421587 |
| CURRENT CPC | Household or Table Equipment A47G 23/0225 (20130101) Original (OR) Class A47G 2400/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245703 | TRAVERS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wright State University (Dayton, Ohio); TheUnited States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey B. TRAVERS (Centerville, Ohio) |
| ABSTRACT | A skin protective composition includes at least one functional inhibitor of an acid sphingomyelinase (FIASM) in a dermatologically acceptable carrier. A method of ameliorating photosensitivity in a subject includes topically administering the skin protective composition to a subject, where the therapeutically effective amount is demonstrated to reduce or eliminate inflammation, microvesicle particle release, erythema, or a combination thereof. In another embodiment, a method inhibits the release of microvesicle particles from skin cells. In another embodiment, a method reduces side effects resulting from a topical photodynamic therapy treatment. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 41/0061 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245728 | Cullen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Kacy Cullen (Media, Pennsylvania); Hannah Hoeun Lee (Bala Cynwyd, Pennsylvania); Robert Shultz (Philadelphia, Pennsylvania); Sam Lien (Cooper City, Florida) |
| ABSTRACT | Provided herein are living scaffolds for peripheral nerve regeneration, the living scaffolds including tissue engineered nerve grafts (TENGs) programmed to express neurogenic growth factors with temporal and spatial control. Further provided herein are compositions and methods for facilitating nerve regeneration, such as compositions and methods comprising TENGs modified to express a neurotrophic growth factor. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) Peptides C07K 14/4756 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245733 | Ward et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); U.S. Govenment Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey Ward (San Francisco, California); Qizhi TANG (San Francisco, California); Peter STOCK (San Francisco, California); Gaetano FALEO (San Francisco, California); Gopika NAIR (San Francisco, California); Matthias HEBROK (San Francisco, California); Wenhan CHANG (San Francisco, California); Thuy VO (San Francisco, California); Jeffrey A. BLUESTONE (San Francisco, California); Elenora DE KLERK (San Francisco, California) |
| ABSTRACT | Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0024 (20130101) A61K 35/39 (20130101) A61K 35/55 (20130101) Original (OR) Class A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0617 (20130101) C12N 5/0676 (20130101) C12N 2506/02 (20130101) C12N 2506/078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240247056 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut); The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Hansen (North Haven, Connecticut); Peter M. Glazer (Guilford, Connecticut); Richard H. Weisbart (Los Angeles, California); Robert N. Nishimura (Santa Monica, California); Grace Chan (Monterey Park, California) |
| ABSTRACT | Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/596375 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/44 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240247933 | Ekholm |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K Ekholm (Falmouth, Massachusetts) |
| ABSTRACT | A device and method of using same having an inertial measurement unit (IMU), a controller, an activator, and an absolute position sensor configured to measure fluid-body waves. The controller calculates its orientation in a relative frame using data obtained from the IMU and fixed-point arithmetic. The controller transforms the relative orientation information into absolute units using data obtained from the absolute sensor and fixed-point arithmetic, producing wave measurements. The controller may then select a subset of wave measurements for transmission via an optional communications mechanism to a remote user. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/600019 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248368 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Su-Peng Yu (Boulder, Colorado); Scott B. Papp (Boulder, Colorado) |
| ABSTRACT | A photonic-crystal resonator (PhCR) and associated methods of design and manufacture. The PhCR includes spontaneous optical-pulse generation and includes a ring whose geometry is correlated to a mode structure or dispersion of the PhCR while also taking into account a desired type of nonlinear optical output from the PhCR, such as an optical frequency comb, or a particular type of pulse. The PhCR includes a periodic nanopatterning on an inner radial wall of its ring and is able to spontaneously generate a nonlinear optical output. The nanopatterning of the inner radial wall is designed to form a desired output, such as one of a classic soliton pulse that has a sech type temporal profile, or a gaussian profile, or a sink pulse profile. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/648913 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249176 | Brady et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lucas Tyler Brady (Greenbelt, Maryland); Alexey Vyacheslavovich Gorshkov (Rockville, Maryland); Christopher Lee Baldwin (Hyattsville, Maryland); Aniruddha Bapat (College Park, Maryland); Yaroslav Kharkov (Washington, District of Columbia); Przemyslaw Dariusz Bienias (Silver Spring, Maryland); Lucas Kocia (Oakland, California) |
| ABSTRACT | A process for bang-anneal-bang quantum optimization includes: identifying base curve v(t); setting a total runtime of the process; creating an initial guess for parameters in an ansatz; creating an initial guess for parameters in an ansatz; evolving a quantum state from a ground state of B following Hamiltonian H(t)=u(t) B+(1−u(t)) C and, at termination of evolving the quantum state, measuring the resulting quantum state; updating the parameters for the ansatz based on the resulting quantum state; repetitively creating the ansatz for u(t), evolving the quantum state from the ground state of B following Hamiltonian H(t), and, at termination of evolving the quantum state, determining the resulting quantum state until the classical outer loop converges to a selected convergence limit; and returning the final form of u(t) to perform bang-anneal-bang quantum optimization. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 18/560591 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20240245481 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Vincent So (San Diego, California); Erik Olson (San Diego, California); Michael Scott (San Diego, California); Chad Green (San Diego, California); Giacomo Strollo (San Diego, California); Gustavo Prado (San Diego, California); Craig McGreevy (San Diego, California); Laura Martinson (San Diego, California); Donald Koenig (San Diego, California) |
| ABSTRACT | Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435390 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 50/00 (20160201) Original (OR) Class A61B 2050/0067 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240245721 | NGUYEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kytai NGUYEN (Austin, Texas); Jon WEIDANZ (Austin, Texas); Serkan YAMAN (Austin, Texas); Harish RAMACHANDRAMOORTHY (Arlington, Texas); Manoj Kumar SABNANI (Arlington, Texas) |
| ABSTRACT | Disclosed are chimeric antigen receptor (CAR) engineered T lymphocyte membrane coated nanoparticles (CAR-T MNP) compositions and methods of using the same for delivering therapeutics to a particular target. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 18/558882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464406 (20230501) A61K 2239/13 (20230501) A61K 2239/29 (20230501) A61K 2239/49 (20230501) A61K 2239/55 (20230501) Peptides C07K 14/7051 (20130101) C07K 16/32 (20130101) C07K 2317/31 (20130101) C07K 2317/53 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240246860 | Panferov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SIERRACRETE LLC (Simi Valley, California) |
| ASSIGNEE(S) | SIERRACRETE LLC (Simi Valley, California) |
| INVENTOR(S) | Evgeny Panferov (Simi Valley, California) |
| ABSTRACT | Composite cellulosic products and processes for making same. In some embodiments, the composite cellulosic product can include a plurality of cellulosic substrates and an at least partially cured binder. Prior to curing, the binder can include a mixture formed by combining magnesium oxide, water, and magnesium chloride. A weight ratio of the magnesium oxide to the magnesium chloride in the binder can be at least 2.2:1 to 8.5:1. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585562 |
| CURRENT CPC | Manufacture by Dry Processes of Articles, With or Without Organic Binding Agents, Made From Particles or Fibres Consisting of Wood or Other Lignocellulosic or Like Organic Material B27N 1/02 (20130101) B27N 3/002 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 26/06 (20130101) C04B 26/28 (20130101) C04B 28/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20240245481 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Vincent So (San Diego, California); Erik Olson (San Diego, California); Michael Scott (San Diego, California); Chad Green (San Diego, California); Giacomo Strollo (San Diego, California); Gustavo Prado (San Diego, California); Craig McGreevy (San Diego, California); Laura Martinson (San Diego, California); Donald Koenig (San Diego, California) |
| ABSTRACT | Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435390 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 50/00 (20160201) Original (OR) Class A61B 2050/0067 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240248047 | Qian |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Yu Qian (Irmo, South Carolina) |
| ABSTRACT | Described herein are a low-cost, non-destructive, and contact-free intelligent inspection system that is field-deployable on a geometry car, high-rail vehicle, or other types of track inspection platforms to identify broken railway/railroad spikes in real-time. |
| FILED | Monday, November 20, 2023 |
| APPL NO | 18/513934 |
| CURRENT CPC | Permanent Way; Permanent-way Tools; Machines for Making Railways of All Kinds E01B 9/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8806 (20130101) G01N 21/9515 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240249516 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | This application relates to a system for automatically recognizing geographical area information provided on an item. The system may include an optical scanner configured to capture geographical area information provided on an item, the geographical area information comprising a plurality of geographical area components. The system may also include a controller in data communication with the optical scanner and configured to recognize the captured geographical area information by running a plurality of machine learning or deep learning models separately and sequentially on the plurality of geographical area components of the captured geographical area information. |
| FILED | Thursday, April 04, 2024 |
| APPL NO | 18/627368 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/28 (20230101) G06F 18/2413 (20230101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class G06V 30/416 (20220101) G06V 30/19173 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249544 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | This application relates to a system for building machine learning or deep learning data sets for automatically recognizing geographical area information comprising a plurality of geographical area components provided on items. The system may include a first image database configured to store a first plurality of sets of images of geographical area information of items, each first set including an image of an entirety of geographical area information of an item. The system may also include a second image database configured to store a second plurality of sets of images of the geographical area information of the items, each second set including images of individual geographical area components. The system may further include a controller configured to convert the first plurality of sets of images into the second plurality of sets of images. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431835 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/29 (20190101) G06F 16/50 (20190101) G06F 18/217 (20230101) Image Data Processing or Generation, in General G06T 1/0007 (20130101) Image or Video Recognition or Understanding G06V 20/62 (20220101) G06V 30/10 (20220101) G06V 30/414 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240245739 | KUCHIPUDI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suresh KUCHIPUDI (State College, Pennsylvania) |
| ABSTRACT | Provided are compositions and methods for prophylaxis or therapy of cancer. The compositions and methods include use of Birnaviridae double stranded RNS (dsRNA) viruses for treating cancer in individuals that are not the normal virus hosts. Modifications of the dsRNA viruses are provided and include genetic changes that result improvements in anti-cancer therapy by increasing onxotoxicity of the modified viruses, and by including sequences encoding therapeutic pay loads. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 18/562068 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2720/10021 (20130101) C12N 2720/10032 (20130101) C12N 2720/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240246086 | DiCicco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joseph A. DiCicco (Cape Mary Court, New Jersey); Andrew Horan (Mays Landing, New Jersey); John Brady (Medford, New Jersey) |
| ABSTRACT | A media holder can be used for preparing samples. The media holder can comprise a base, a pair of walls extending upwardly from the base, and a plurality of transverse members positioned on and coupled to a respective upper end of each of the walls. Each of the transverse members can define a receiving slot for receiving at least a portion of a media therein. |
| FILED | Thursday, March 14, 2024 |
| APPL NO | 18/605692 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 9/523 (20130101) Original (OR) Class B01L 2200/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20240246009 | Bhalekar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prakash Bhalekar (Minneapolis, Minnesota); Mustafa F. Kaddoura (Minneapolis, Minnesota); Natasha C. Wright (Shakopee, Minnesota) |
| ABSTRACT | A system includes an evaporator having sensors and selectable operational parameters and a controller configured to receive data and determine operational configuration for the evaporator. Selectable parameters relate to system heating, liquid flow rate, air flow rate, and environmental data. |
| FILED | Tuesday, February 13, 2024 |
| APPL NO | 18/440541 |
| CURRENT CPC | Separation B01D 1/22 (20130101) Original (OR) Class B01D 1/0064 (20130101) B01D 1/0082 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/008 (20130101) C02F 1/08 (20130101) C02F 1/048 (20130101) C02F 2201/005 (20130101) C02F 2209/02 (20130101) C02F 2209/38 (20130101) C02F 2209/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240251526 | Hofmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Douglas C. Hofmann (Altadena, California); Scott N. Roberts (Altadena, California); Benjamin I. Furst (Altadena, California) |
| ABSTRACT | Amorphous metal thermal management devices are described. The amorphous metal thermal management devices are advanced heat transfer systems that utilize the unique properties of amorphous metal to transfer heat away from components that generate heat in numerous applications. These devices feature either rigid or flexible vapor chambers, for dissipating heat and can be used to cool a wide range of devices. The resulting cooling solution is both effective and reliable. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/423219 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 2255/02 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20336 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240246072 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GeneCapture, Inc. (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Greg Thompson (Scottsboro, Alabama); Zachary McGee (Huntsville, Alabama); Paula Millirons (Owens Cross Roads, Alabama) |
| ABSTRACT | Integrated cartridges for sample homogenization, nucleic acid fragmentation, and nucleic acid detection are disclosed herein. The integrated cartridges include a main housing having a sample well and a detection chamber and a sonication feature coupled to and extending outwardly from the main housing. The sonication feature includes a sonication chamber for receiving a sample fluid. A fluidic path directs the sample fluid from the sample well, to the sonication chamber, and to the detection chamber. Systems for use with the integrated cartridges can include sonotrodes with openings for positioning the sonication feature and/or temperature sensors for monitoring the temperature of the sonication feature. Methods include moving the sample fluid from the sample well to the sonication feature, transmitting ultrasonic energy into the sample fluid, moving the sample fluid from the sonication feature to the detection chamber, and performing a nucleic acid detection assay within the detection chamber. |
| FILED | Monday, January 29, 2024 |
| APPL NO | 18/425316 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 2200/147 (20130101) B01L 2300/0663 (20130101) B01L 2300/1805 (20130101) B01L 2300/1894 (20130101) B01L 2400/0436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240247614 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Ryan Johnson (Fairfield, Ohio); Paul Hadley Vitt (Liberty Twp, Ohio); Eric Joseph Schroeder (Loveland, Ohio); Carlos Gilberto Fernandez-Soto (Fairfield Twp, Ohio) |
| ABSTRACT | A turbine engine and method of operating includes an engine core with a compressor, a combustor, and a turbine in axial flow arrangement. A flow path extends through the engine core from the compressor to the turbine to define a flow direction for a working airflow through the engine core. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/625749 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240249639 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Specular Theory, Inc. (Venice, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchel Thompson (Livermore, California); Daniel Michelson (Oakland, California) |
| ABSTRACT | Aircraft simulation yokes, and associated systems and methods are disclosed herein. A representative system includes a yoke handle, and an anchoring device operably connected to the yoke handle. The anchoring device includes a first linkage pivotably coupled to a first section of the yoke handle, a second linkage pivotably coupled to a second section of the yoke handle, and a connector coupled to the first linkage and the second linkage. When the yoke handle is pushed or pulled, a translational movement of one of the linkages is greater than a translational movement of the other linkage such that the yoke handle tilts about a rotation axis offset from the yoke handle. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158931 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 25, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240725.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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