FedInvent™ Patent Applications
Application Details for Thursday, August 08, 2024
This page was updated on Thursday, August 08, 2024 at 02:15 PM GMT
Department of Health and Human Services (HHS)
| US 20240260567 | WOODS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ossium Health, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik J. WOODS (Carmel, Indiana); Brian H. JOHNSTONE (Fishers, Indiana) |
| ABSTRACT | The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing. |
| FILED | Tuesday, December 19, 2023 |
| APPL NO | 18/545891 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0284 (20130101) Original (OR) Class A01N 1/0289 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 5/0663 (20130101) C12N 2509/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260858 | Dhar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sumitrajit Dhar (Wilmette, Illinois); Shawn Goodman (Iowa City, Iowa); Courtney Shea Coburn Glavin (Chicago, Illinois) |
| ABSTRACT | A method of conducting an otoacoustic emission test includes emitting, by a signal generator, a stimulus tone that is to be received by a user, where the stimulus tone comprises a swept level stimuli. The method also includes recording, in a memory of a computing device, otoacoustic emissions generated by an inner ear of the user, where the otoacoustic emissions are in response to the stimulus tone. The method further includes determining, by a processor of the computing device, one or more health characteristics of the inner ear of the user based at least in part on the recorded otoacoustic emissions. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434313 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/126 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260866 | Kovatchev et al. |
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| FUNDED BY |
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| APPLICANT(S) | ABBOTT DIABETES CARE INC. (Alameda, California) |
| ASSIGNEE(S) | ABBOTT DIABETES CARE INC. (Alameda, California) |
| INVENTOR(S) | Boris P. Kovatchev (Charlottesville, Virginia); Christopher R. King (Chicago, Illinois) |
| ABSTRACT | A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors. |
| FILED | Thursday, March 07, 2024 |
| APPL NO | 18/598133 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1495 (20130101) Original (OR) Class A61B 5/7203 (20130101) A61B 5/7275 (20130101) A61B 5/7278 (20130101) A61B 5/14532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260875 | GURCHIEK et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reed GURCHIEK (Essex Junction, Vermont); Ryan MCGINNIS (Shelburne, Vermont) |
| ABSTRACT | A system for determining dynamics of a joint of an individual includes a first muscle contraction sensor configured to measure an excitation of a first muscle adjacent to a joint; a first movement sensor configured to measure movement on a first side of the joint; a second muscle contraction sensor configured to measure an excitation of a second muscle located adjacent to the joint; and a second movement sensor configured to measure movement on a second side of the joint. A machine learning processor is trained to determine a full set of excitation values based on an excitation value from the first muscle contraction sensor and an excitation value from the second muscle contraction sensor. A processor is configured to determine a joint moment based on values from the first and second movement sensors and the set of excitation values from the machine learning processor. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 18/560644 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/224 (20130101) Original (OR) Class A61B 5/389 (20210101) A61B 5/1107 (20130101) A61B 5/4528 (20130101) A61B 5/6802 (20130101) A61B 5/7264 (20130101) A61B 2562/06 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260883 | PRISCO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the Univeristy of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Robert PRISCO (Minneapolis, Minnesota); Venkatakrishna THOLAKANAHALLI (Minneapolis, Minnesota); Matthew OLSON (Minneapolis, Minnesota) |
| ABSTRACT | A system for VT localization comprises an electrocardiograph (ECG) device for detecting electrical signals of a ventricular fibrillation event in a patient and producing ECG data, a localizer, and a display device. The localizer comprises a memory and a processor, the memory storing a model and one or more parameters of the model. The memory further stores instructions that when executed by the processor cause the processor to receive the ECG data, and generate a determination indicating whether a detected VT signal arose from an endocardial surface or epicardial surface based on signal averaged waveform for each of the leads. The display device is configured to output the determination, which can also be communicated to follow-on provider systems. |
| FILED | Wednesday, July 20, 2022 |
| APPL NO | 18/290643 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/271 (20210101) A61B 5/283 (20210101) A61B 5/339 (20210101) A61B 5/363 (20210101) Original (OR) Class A61B 5/367 (20210101) A61B 5/686 (20130101) A61B 2562/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260909 | Tichauer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Tichauer (Chicago, Illinois); Robert W. Holt (Lebanon, New Hampshire); Frederic Leblond (Montreal, Canada); Pablo Valdes (Hanover, New Hampshire); Brian W. Pogue (Hanover, New Hampshire); Keith D. Paulsen (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire) |
| ABSTRACT | A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/614944 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0062 (20130101) A61B 5/0071 (20130101) A61B 5/7278 (20130101) Original (OR) Class A61B 2576/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260916 | Wagner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Wagner (Madison, Wisconsin); Joseph Whitehead (Madison, Wisconsin); Michael Speidel (Madison, Wisconsin); Paul Laeseke (Madison, Wisconsin) |
| ABSTRACT | A system and method are provided that includes acquiring or accessing x-ray data of a subject experiencing a delivery of a contrast agent to the vessel of the subject and generating time-attenuation curves for the vessel using the x-ray data. The method also includes identifying a plurality of points within the vessel and extending along a lumen of the vessel and sampling the time-attenuation curves at the plurality of points to generate a time-attenuation map. The method further includes performing a Fourier transform on the time-attenuation map to generate a spatio-temporal map of spatial frequency versus temporal frequency and identifying a peak frequency in the spatio-temporal map corresponding to flow or velocity in the vessel. The method then includes quantifying the flow or velocity within the vessel of the subject using the peak frequency and generating a report including quantified flow or velocity through the vessel. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163475 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/481 (20130101) A61B 6/504 (20130101) Original (OR) Class A61B 6/5217 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/254 (20170101) G06T 2207/10116 (20130101) G06T 2207/30104 (20130101) G06T 2207/30172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260935 | Reiche et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher F. Reiche (Salt Lake City, Utah); Florian Solzbacher (Salt Lake city, Utah); Navid Farhoudi (Salt Lake City, Utah); Steven M. Blair (Salt Lake City, Utah); Jules J. Magda (Salt Lake City, Utah); Lars B. Laurentius (Cottonwood Heights, Utah); Prattay Deepta Kairy (Salt Lake City, Utah) |
| ABSTRACT | Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte. |
| FILED | Friday, March 29, 2024 |
| APPL NO | 18/621918 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4272 (20130101) Original (OR) Class A61B 8/4483 (20130101) A61B 8/5207 (20130101) A61B 2562/028 (20130101) A61B 2562/0204 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240260967 | Maitland et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); SHAPE MEMORY MEDICAL, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan J. Maitland (College Station, Texas); Todd L. Landsman (San Jose, California); Jennifer N. Rodriguez (Fremont, California); Anthony J. Boyle (College Station, Texas); Alan C. Glowczwski (College Station, Texas); Mark A. Wierzbicki (College Station, Texas) |
| ABSTRACT | An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit. |
| FILED | Wednesday, March 27, 2024 |
| APPL NO | 18/618018 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1215 (20130101) A61B 17/1219 (20130101) Original (OR) Class A61B 17/12109 (20130101) A61B 17/12172 (20130101) A61B 2017/00526 (20130101) A61B 2017/00871 (20130101) A61B 2017/00898 (20130101) A61B 2017/12063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261057 | McIntyre et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cameron McIntyre (Cleveland, Ohio); Angela Noecker (Cleveland, Ohio); Jeffrey Mlakar (Cleveland, Ohio); Mark Griswold (Cleveland, Ohio) |
| ABSTRACT | Systems, methods, and media for presenting biophysical simulations in an interactive mixed reality environment are provided. In some embodiments, a system comprises: a head mounted display comprising: a transparent display; sensors; and a processor programmed to: receive medical imaging data associated with a subject; receive, from a server, information useable to visualize a simulation of biophysical processes and a subject-specific anatomical model based on the medical imaging data; cause a visualization of the simulation to be presented, via the transparent display, in connection with the medical imaging data and an instrument in a first position; receive, from the server, updated information useable to visualize an updated simulation with the instrument in a second position; and cause a visualization of the updated simulation to be presented with the instrument presented in the second position. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/566463 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 34/10 (20160201) A61B 90/37 (20160201) Original (OR) Class A61B 2034/102 (20160201) A61B 2034/105 (20160201) A61B 2090/365 (20160201) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261117 | Herr et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hugh M. Herr (Concord, New Hampshire); Duncan Ru Chieh Lee (Cambridge, Massachusetts); Christina Meyer (Cambridge, Massachusetts); Dana Solav (Caesarea, Israel); Xingbang Yang (Beijing, China PRC) |
| ABSTRACT | Aspects of inventive concepts are generally directed to a liner, methods of use, methods of design, and related systems. In various embodiments, the liner is configured to serve as an interface between an external surface of a biological body segment of a subject and a prosthetic socket, the biological body segment being amputated below a joint. In various embodiments, a pressure applied by the liner to the biological body segment varies over the length of the liner with a maximum pressure applied at the joint and a lesser pressure applied below the joint. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/527057 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/7812 (20130101) Original (OR) Class A61F 2002/7818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261239 | Wellman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | D. Andrew Wellman (Wayland, Massachusetts); Luigi Taranto-Montemurro (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594885 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/216 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261245 | PAPAGIANNAKOPOULOS et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
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| INVENTOR(S) | Thales PAPAGIANNAKOPOULOS (New York, New York); Tyler JACKS (Cambridge, Massachusetts); Rodrigo ROMERO (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to a method of treating a subject having cancer that includes selecting a subject having cancer associated with a deregulated NRF2/KEAP1 pathway and administering to the selected subject one or more inhibitors comprising a glutamine transporter inhibitor, a GPD2 inhibitor, or combination(s) thereof. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/530612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 31/282 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/655 (20130101) A61K 31/675 (20130101) A61K 31/4184 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 33/243 (20190101) A61K 38/20 (20130101) A61K 38/21 (20130101) A61K 38/50 (20130101) A61K 38/191 (20130101) A61K 38/193 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261264 | Kashyap et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purna C. Kashyap (Rochester, Minnesota); Michael Fischbach (Portola Valley, California); Brianna B. Williams (Oakland, California) |
| ABSTRACT | This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537398 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/405 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 2035/115 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261302 | Jensen et al. |
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| FUNDED BY |
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| APPLICANT(S) | FloraScience Inc. (Milwaukie, Oregon); The Salk Institute for Biological Studies (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Paul Jensen (Portland, Oregon); Pamela Maher (San Diego, California); Zhibin Liang (San Diego, California) |
| ABSTRACT | Provided are methods of treating a neurodegenerative disease or condition in a subject in need thereof including administering a cannabinoid to the subject. |
| FILED | Wednesday, January 03, 2024 |
| APPL NO | 18/403664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/658 (20230501) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261333 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia Joung (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to identifying novel tumor immune evasion targets. A CRISPR activation screen was employed to identify novel checkpoint inhibitor targets, where upon upregulation, conferred tumor resistance to cytotoxic T cells in model cancer cell lines. Using MAGeCK and FDR analyses to identify candidate genes that were enriched in cancer cells, B3GNT2, MCL1, BCL2A1 and JUNB were identified as the most enriched after a pathway analysis of the top 576 genes prioritized by MAGeCK. Currently, these four genes have not been identified or suggested as possible checkpoint inhibitor targets. Provided herein are methods of targeting the expression or activity of B3GNT2, MCL1, BCL2A1 and JUNB using small molecule agents and/or gene editing methods with the aim of enhancing anti-tumor immunity in subjects in need thereof. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/565668 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464488 (20230501) A61K 45/06 (20130101) A61K 47/6815 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/1137 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 204/01149 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261334 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623246 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261337 | BURGESS et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Claire BURGESS (Boston, Massachusetts); Darrell Kotton (Newton, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods of producing or differentiating AT1 cells, and AT1 cells made by the methods described herein. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/541448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/42 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) C12N 15/86 (20130101) C12N 2500/90 (20130101) C12N 2501/11 (20130101) C12N 2501/117 (20130101) C12N 2501/119 (20130101) C12N 2501/727 (20130101) C12N 2513/00 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261369 | Puri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | Ohio University (Athens, Ohio) |
| INVENTOR(S) | Vishwajeet Puri (Athens, Ohio); John J. Kopchick (Athens, Ohio); Vishva Sharma (Athens, Ohio) |
| ABSTRACT | Methods and FSP27 compositions for treating and/or preventing metabolic disease and conditions associated insulin resistance, obesity, inflammation and dyslipidemia are described. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261370 | Sinclair et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Sinclair (Cambridge, Massachusetts); Yuancheng Lu (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g., engineered nucleic acids), engineered cells, compositions comprising the engineered nucleic acids, the recombinant viruses, engineered cells, engineered proteins, chemical agents that are capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, an engineered protein selected from the group consisting of OCT4; KLF4; SOX2; or any combination thereof, an antibody capable of activating expression of OCT4; KLF4; SOX2; or any combination thereof, and methods of treating a (e.g., ocular disease), preventing a disease (e.g., ocular disease), regulating (e.g., inducing or inducing and then stopping) cellular reprogramming, regulating tissue repair, regulating tissue regeneration, or any combination thereof). |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 38/1709 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261378 | Deretic |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | STC UNM (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vojo Deretic (Placitas, New Mexico) |
| ABSTRACT | Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRIM 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer. |
| FILED | Monday, July 31, 2017 |
| APPL NO | 16/321699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/137 (20130101) A61K 31/155 (20130101) A61K 31/436 (20130101) A61K 31/616 (20130101) A61K 31/702 (20130101) A61K 31/4375 (20130101) A61K 31/7016 (20130101) A61K 38/53 (20130101) Original (OR) Class A61K 38/1732 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261383 | Sun |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingmin Sun (Temple Terrace, Florida) |
| ABSTRACT | A novel vaccine and methods of preventing and treating C. difficile infection in a patient is described. The vaccine is comprised of a fusion protein (denoted FliCD) comprised of the FliC and FliD from C. difficile and joined by a linker sequence. Administration of the vaccine, as well as anti-FliCD serum, has been shown to prevent C. difficile infection as well as treat existing infections. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390057 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) A61K 39/08 (20130101) Original (OR) Class Peptides C07K 14/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261393 | Reed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HDT Bio Corp. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Gregory Reed (Bellevue, Washington); Darrick Albert Carter (Seattle, Washington); Amit Praful Khandhar (Issaquah, Washington); Jacob Freeman Archer (Seattle, Washington); Lars Peter Aksel Berglund (Seattle, Washington); Jesse Erasmus (Port Orchard, Washington); Bryan Berube (Issaquah, Washington); Malcolm S. Duthie (Sammamish, Washington) |
| ABSTRACT | The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided. |
| FILED | Thursday, March 21, 2024 |
| APPL NO | 18/612698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/1075 (20130101) A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/55505 (20130101) A61K 2039/55516 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261402 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katharine C Hsu (New York, New York); Mohammed Kazim Panjwani (New York, New York); Rosa Sottile (New York, New York); Jean-Benoit Luduec (New York, New York) |
| ABSTRACT | The present invention provides NKG2C+CD8+ T cells, including engineered NKG2C+CD8+ T cells expressing chimeric antigen receptor (CAR) A molecules or transgenic T cell receptors, compositions comprising such cells, methods of generating such cells from conventional CD8+ T cells, and methods of using such cells, for example in adoptive cell therapy methods. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 18/560436 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) Original (OR) Class A61K 39/4631 (20230501) A61K 39/4632 (20230501) A61K 39/464412 (20230501) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) C07K 2317/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261413 | Cloyd |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Minnesota (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James C. Cloyd (Edina, Minnesota) |
| ABSTRACT | The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same. |
| FILED | Friday, April 05, 2024 |
| APPL NO | 18/628449 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/357 (20130101) A61K 31/724 (20130101) A61K 47/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261416 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Weiping Tang (Middleton, Wisconsin); Haibo Xie (Shanghai, China PRC); Yunxiang Wu (Madison, Wisconsin); Junzhuo Liao (New York, New York); Chunrong Li (Madison, Wisconsin); Ira Tandon (Madison, Wisconsin); Hua Tang (Madison, Wisconsin) |
| ABSTRACT | Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs. |
| FILED | Tuesday, January 30, 2024 |
| APPL NO | 18/426920 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class Heterocyclic Compounds C07D 239/22 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261420 | FLYNN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GanNA Bio, Inc. (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Alexander FLYNN (Brookline, Massachusetts); Brian GOODMAN (Boston, Massachusetts); Ciaran LAWLOR (Milton, Massachusetts); Namita BISARIA (Somerville, Massachusetts); Richard D. CUMMINGS (Brookline, Massachusetts); Mohui WEI (Boston, Massachusetts); Carolyn R. BERTOZZI (Menlo Park, California) |
| ABSTRACT | The present disclosure relates to glyconucleic acids, such as glycoRNA and glycoDNA described herein. Provided are glycosylated ribonucleic acid (glycoRNA)-related methods and compositions. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/61 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261428 | Steinmetz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Sourabh Shukla (Cleveland, Ohio) |
| ABSTRACT | A pepino mosaic virus (PepMV) carrier comprising a PepMV particle that has been modified to carry an imaging agent or anticancer agent is described. The PepMV carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the PepMV carrier can be imaged using an imaging agent, or treated using an anticancer agent. |
| FILED | Tuesday, February 13, 2024 |
| APPL NO | 18/440126 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/6901 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261429 | Steinmetz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (La Jolla, California); Soo Khim Chan (La Jolla, California) |
| ABSTRACT | This disclosure provides a conjugate comprising a 7-mer peptide bound to the surface of a viral particle such as cowpea mosaic virus (CPMV). The c terminus of this peptide can be conjugated to desired molecules with the N terminus of the peptide interacting with CPMV surface. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/569998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) A61K 47/6901 (20170801) Original (OR) Class Peptides C07K 7/06 (20130101) C07K 14/005 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/18022 (20130101) C12N 2770/18023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261436 | KHALILI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamel KHALILI (Bala Cynwyd, Pennsylvania); Rafal KAMINSKI (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a retrovirus and a receptor used by a retrovirus for infecting a cell. The CRISPR construct edits, for example, proviral HIV DNA, thereby eliminating the provirus from an infected cell and simultaneously edits a viral receptor, e.g. CCR5 preventing infection and reinfection of the host. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566468 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/505 (20130101) A61K 31/4985 (20130101) A61K 31/7068 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1132 (20130101) C12N 15/1138 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261440 | WEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Tuo WEI (Dallas, Texas); Yehui SUN (Dallas, Texas); Qiang CHENG (Dallas, Texas); Daniel SIEGWART (Dallas, Texas) |
| ABSTRACT | Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 47/24 (20130101) A61K 47/543 (20170801) A61K 48/0066 (20130101) Original (OR) Class Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261441 | ASSOULINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NANOMEDTRIX, LLC (Coralville, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joe G. ASSOULINE (Coralville, Iowa); Sean K. SWEENEY (Coralville, Iowa) |
| ABSTRACT | Mesoporous silica nanoparticles (MSNs) that may be useful as ultrasound contrast agents for detecting and treating bladder cancer are described herein. The MSNs include a lanthanide, a fluorophore, and an agent detectable by ultrasound. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/620709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/16 (20130101) A61K 49/0089 (20130101) A61K 49/1824 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261444 | Kadassery et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Karthika J. Kadassery (Ithaca, New York); Justin Wilson (Ithaca, New York) |
| ABSTRACT | The present technology provides compounds, as well as compositions including such compounds, useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing e.g., a glypican-3 (GPC3) receptor and/or prostate specific membrane antigen, where the compounds are represented by the Formulas (I) or a pharmaceutically acceptable salt and/or solvate thereof, (II) or a pharmaceutically acceptable salt and/or solvate thereof, (III) or a pharmaceutically acceptable salt and/or solvate thereof, wherein M1 is independently at each occurrence a radionuclide. Equivalents of such compounds are also disclosed. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/562744 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) Original (OR) Class A61K 51/1096 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261459 | Rege et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushal Rege (Chandler, Arizona); Deepanjan Ghosh (Tempe, Arizona) |
| ABSTRACT | A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound. |
| FILED | Tuesday, January 02, 2024 |
| APPL NO | 18/402138 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 31/417 (20130101) A61K 33/242 (20190101) A61K 38/39 (20130101) A61K 38/1825 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/18 (20130101) A61L 15/20 (20130101) A61L 15/32 (20130101) A61L 15/44 (20130101) Original (OR) Class A61L 26/0004 (20130101) A61L 26/008 (20130101) A61L 26/0066 (20130101) A61L 26/0095 (20130101) A61L 2300/45 (20130101) A61L 2300/102 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/067 (20210801) A61N 5/0616 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261472 | REYNOLDS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel S. REYNOLDS (Cambridge, Massachusetts); Jennifer A. Lewis (Cambridge, Massachusetts) |
| ABSTRACT | A bioink for extrusion-based printing includes an extracellular matrix (ECM) precursor comprising an uncrosslinked polymer, and sacrificial microparticles dispersed in the ECM precursor. The sacrificial microparticles have a melting temperature above a crosslinking temperature of the uncrosslinked polymer. A method of fabricating a tissue/organ model or therapeutic construct comprises extruding a bioink comprising a first ECM precursor and first sacrificial microparticles through a nozzle moving relative to a deposition bath, and depositing an extruded filament comprising the bioink into the deposition bath as the nozzle moves. After deposition, the first ECM precursor is crosslinked to form a first ECM material, and after the crosslinking, the first sacrificial microparticles are melted to form pores in the first ECM material. The pores may have a width or diameter comparable to that of individual cells. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/567448 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) Original (OR) Class A61L 27/54 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/40 (20170801) B29C 64/106 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/03 (20130101) C09D 11/04 (20130101) C09D 11/08 (20130101) C09D 11/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261474 | Maminishkis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Arvydas Maminishkis (Washington, District of Columbia); Kapil Bharti (Potomac, Maryland); Davide Ortolan (Bethesda, Maryland); Ruchi Sharma (Bethesda, Maryland); Eric Nguyen (North Bethesda, Maryland) |
| ABSTRACT | A scaffold containing two layers is provided for attaching retinal pigment epithelial (RPE) cells, photoreceptor progenitor (PRP) cells, or both. The scaffold includes a first layer containing poly(lactic-co-glycolic acid) (PLGA), and a second layer containing polycaprolactone (PCL) loops. Scaffolds containing mature RPE cells and PRP cells can be implanted into the eye of a subject to treat a retinal degenerative disease, retinal dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/290396 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 27/3813 (20130101) A61L 2400/12 (20130101) A61L 2430/16 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 5/0621 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261533 | GARZA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristie Michelle GARZA (Decatur, Georgia); Annabelle C. SINGER (Atlanta, Georgia); Levi WOOD (Atlanta, Georgia); Abigail L. PAULSON (Atlanta, Georgia) |
| ABSTRACT | Methods for controlling brain activity in a subject are described herein. An example method can include delivering a stimulus to the subject, wherein the stimulus induces neural activity in the subject's brain and modulates expression of at least one soluble mediator of cellular activity (such as, for example, a cytokine, chemokine, and/or growth factor) within the subject, and the stimulus is delivered to the subject for less than one hour. |
| FILED | Thursday, March 21, 2024 |
| APPL NO | 18/612453 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/00 (20130101) Original (OR) Class A61M 2021/0027 (20130101) A61M 2021/0044 (20130101) A61M 2021/0055 (20130101) A61M 2021/0072 (20130101) A61M 2250/00 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) A61N 2/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261572 | Leuthardt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WASHINGTON UNIVERSITY (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Leuthardt (St. Louis, Missouri); Peter Brunner (St. Louis, Missouri); Kara Donovan (St. Louis, Missouri) |
| ABSTRACT | A method of enhanced motor learning is provided. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within the patient's ear with a nerve stimulating signal. The method also includes assisting the patient in performing a physical activity while the patient's vagus nerve is stimulated. The method further includes monitoring one or more statistics of the patient during the physical activity. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/566890 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36025 (20130101) A61N 1/36031 (20170801) Original (OR) Class A61N 1/36034 (20170801) A61N 1/36036 (20170801) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261720 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jeffrey R. Long (Berkeley, California); Benjamin E. R. Snyder (Champaign, Illinois); Ari B. Turkiewicz (Berkeley, California); Hiroyasu Furukawa (Berkeley, California); Maria V. Paley (Berkeley, California); Ever O. Velasquez (Berkeley, California); Matthew N. Dods (Berkeley, California) |
| ABSTRACT | A porous metal-organic framework M(dicarboxylate), where M=a divalent transition metal ion or alkaline earth metal ion, and (dicarboxylate)=a dicarboxylate linker with a layered two-dimensional structure with paddlewheel-type metal nodes forming a three-dimensional structure with rhombic channels along a c axis. The M(dicarboxylate) family of frameworks, where M=Cu, Fe, Cr, Mg, Ca, Mn, Co, Ni, Zn, Mo or Cd and (dicarboxylate)=trans-1,4-cyclohexanedicarboxylate, 1,4-benzenedicarboxylate, 4,4′-biphenyldicarboxylate, or 2,3,5,6-tetrafluorobenzenedicarboxylate, reversibly binds ammonia via cooperative insertion into its metal-carboxylate bonds to form a dense, one-dimensional coordination polymer that has rapid adsorption kinetics, a comparatively large working capacity and minimal expansion upon ammonia capture. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434724 |
| CURRENT CPC | Separation B01D 53/0462 (20130101) Original (OR) Class B01D 2253/204 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/024 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 11/005 (20130101) C07F 15/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262791 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei Wang (San Francisco, California); Wei Sun (San Francisco, California); Paul C. Klauser (San Francisco, California); Li Cao (San Francisco, California); Bingchen Yu (San Francisco, California); Nanxi Wang (San Francisco, California); Shanshan Li (San Francisco, California); Michael J. Evans (South San Francisco, California) |
| ABSTRACT | Provided herein are inter alia, unnatural amino acids based on fluorosulfonyloxybenzoyl-L-lysine FSK, proteins comprising unnatural amino acids, nanobodies comprising unnatural amino acids based on fluorosulfate-L-tyrosine FSY, meta-FSY and FFY within CDR1, CDR2, or CDR3, biomolecule conjugates, and methods of making the proteins and biomolecule conjugates. |
| FILED | Thursday, April 28, 2022 |
| APPL NO | 18/288679 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 305/26 (20130101) Original (OR) Class C07C 309/87 (20130101) C07C 309/88 (20130101) C07C 309/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262817 | Disney |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Matthew D. Disney (Gainesville, Florida) |
| ABSTRACT | A group of quinazoline compounds has been developed that interrupt the r(CCUG)exp-MBNL1 complex and lessen pre-mRNA splicing errors due to sequestered activation and inhibition regulator MBNL1. A method of treatment of myotonic dystrophy type 2 using these quinazoline compounds has been developed. |
| FILED | Wednesday, July 13, 2022 |
| APPL NO | 18/560558 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Original (OR) Class C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262822 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taekyu Lee (Brentwood, Tennessee); Kevin B. Teuscher (Nashville, Tennessee); Somenath Chowdhury (Nashville, Tennessee); Jianhua Tian (Montgomery Village, Maryland); Kenneth M. Meyers (Nashville, Tennessee); Stephen W. Fesik (Nashville, Tennessee) |
| ABSTRACT | Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/559184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/4725 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 471/04 (20130101) Original (OR) Class C07D 491/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262831 | BANNISTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | VOVA IDA THERAPEUTICS, INC. (Jupiter, Florida); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. BANNISTER (Palm Beach Gardens, Florida); Corinne LASMEZAS (Palm Beach Gardens, Florida); Minghai ZHOU (Jupiter, Florida); Anna Albertson (Jupiter, Florida) |
| ABSTRACT | Provided are, inter alia, compounds having a structure of Formulae (X), (I) to (XIII) or a subordinate structure thereof, composition including the same and methods of use. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 18/257798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/4178 (20130101) A61K 31/4365 (20130101) A61K 31/4709 (20130101) Heterocyclic Compounds C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262840 | Ye |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Keqiang Ye (Atlanta, Georgia) |
| ABSTRACT | In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. |
| FILED | Monday, April 08, 2024 |
| APPL NO | 18/629562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/4184 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 491/052 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262867 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun O. Liu (Clarksville, Maryland); Jingxin Wang (Baltimore, Maryland); Zufeng Guo (Baltimore, Maryland); Wei Li (Xiangtan, China PRC); Shridhar Bhat (Cockeysville, Maryland); Manisha Das (Centreville, Maryland) |
| ABSTRACT | Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435939 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 31/4353 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) C07D 498/04 (20130101) C07D 498/14 (20130101) C07D 515/04 (20130101) C07D 515/14 (20130101) Peptides C07K 7/645 (20130101) Original (OR) Class C07K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262870 | HARDING et al. |
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| FUNDED BY |
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| APPLICANT(S) | VaxNewMo LLC (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian HARDING (St. Louis, Missouri); Mario FELDMAN (St. Louis, Missouri) |
| ABSTRACT | Provided herein are glycosylated ComP proteins, fragments and fusion proteins thereof, and methods of making, for example, for use in the production of conjugate vaccines. Also provided herein are conjugate vaccines against diseases including bacterial diseases. |
| FILED | Thursday, March 14, 2024 |
| APPL NO | 18/605436 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/05 (20130101) A61K 39/092 (20130101) A61K 39/0266 (20130101) A61K 2039/575 (20130101) A61K 2039/6037 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) Original (OR) Class C07K 2319/55 (20130101) C07K 2319/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262873 | SAHAY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida); RISE THERAPEUTICS, LLC (ROCKVILLE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BIKASH SAHAY (GAINESVILLE, Florida); GARY FANGER (ROCKVILLE, Maryland); JYOTI JHA (CLARKSBURG, Maryland); CHRISTIAN FURLAN FREGUIA (GERMANTOWN, Maryland) |
| ABSTRACT | The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to synthesize surface layer protein A (SlpA). Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant bacterium, for example L. lactis cells, or a therapeutically effective amount of the isolated SlpA. The recombinant bacteria cells or SlpA isolated from the recombinant bacteria can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/568888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) A61K 45/06 (20130101) Peptides C07K 14/335 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262875 | Fawzi |
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| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas Lux Fawzi (Providence, Rhode Island) |
| ABSTRACT | Provided herein are compositions and methods useful in treating diseases such as ALS and FTD. Disclosed compositions and methods can prevent protein aggregation, particularly with regard to RNA-binding proteins. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436385 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/435 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262878 | MO |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chia Hao MO (Chicago, Illinois) |
| ABSTRACT | This invention relates to a modified gasdermin protein having a photoactivatable linker inserted between the C-terminal domain and N-terminal domain a gasdermin protein, nucleic acids and vectors encoding the modified gasdermin protein, and methods of using the modified gasdermin protein to introduce agents into cells and facilitate the treatment of diseases or conditions. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/567159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/00 (20130101) Peptides C07K 14/4747 (20130101) Original (OR) Class C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262882 | ROYBAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond LIU (San Francisco, California); Iowis ZHU (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393538 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/09 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262893 | MCGREGOR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Applied Biomedical Science Institute (San Diego, California); Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | Applied Biomedical Science Institute (San Diego, California); Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | Duncan MCGREGOR (San Diego, California); Ruiqi HUANG (San Diego, California); Gabrielle WARNER JENKINS (San Diego, California); Vaughn SMIDER (San Diego, California); Kyeong-Ok CHANG (Manhattan, Kansas); Waithaka MWANGI (Manhattan, Kansas) |
| ABSTRACT | Provided herein are binding polypeptides, such as binding peptides and antibodies, against a SARS CoV-2. The binding polypeptides relate to or are based on bovine antibodies, particularly those containing an ultralong CDR3. Also provided herein are methods of treating a virus infection, such as a coronavirus infection, by delivering to a subject in need a provided binding polypeptide. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/560371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0073 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262895 | Nussenzweig et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Natalia T. Freund (New York, New York); Pamela J. Bjorkman (Altadena, California); Louise Scharf (Porter Ranch, California) |
| ABSTRACT | This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof. |
| FILED | Wednesday, December 20, 2023 |
| APPL NO | 18/390486 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/21 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262957 | Ng et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNIVERSITY OF SOUTHERN MISSISSIPPI (Hattiesburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tse Nga Ng (San Diego, California); Lulu Yao (San Diego, California); Jason Azoulay (Hattiesburg, Mississippi) |
| ABSTRACT | Embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. The conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. The conjugated backbone may comprise a connection of π-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalization—thereby stabilizing charge for the polymer. The carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/608450 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/44 (20130101) C08G 2261/124 (20130101) C08G 2261/514 (20130101) C08G 2261/3223 (20130101) C08G 2261/3246 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 2201/001 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/121 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) H01G 11/48 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263134 | Studer et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Lorenz Studer (New York, New York); Jae-Won Shim (New York, New York); Sonja Kriks (New York, New York) |
| ABSTRACT | The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hESC) in addition to nonembryonic human induced pluripotent stem cells (hiPSC), somatic stem cells, stem cells from patients with a disease, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hESC and/or hiPSC into floor plate midbrain progenitor cells and then further into large populations of midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons using novel culture conditions. The midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons made using the methods of the present invention are further contemplated for various uses including, but not limited to, use in in vitro drug discovery assays, neurology research, and as a therapeutic to reverse disease of, or damage to, a lack of dopamine neurons in a patient. Further, compositions and methods are provided for differentiating midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons from human pluripotent stem cells for use in disease modeling, in particular Parkinson's disease. Additionally, authentic DA neurons are enriched for markers, such as CD142, and A9 type neuronal cells. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 5/0623 (20130101) C12N 2501/01 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/41 (20130101) C12N 2501/119 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263136 | Cafri et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Gal Cafri (Kibbutz Nir David, Israel); Paul F. Robbins (Chevy Chase, Maryland); Jared J. Gartner (Gaithersburg, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of preparing an isolated population of dendritic cells, isolated populations of dendritic cells prepared by the methods, and pharmaceutical compositions comprising the isolated population of dendritic cells. Also disclosed are methods of treating or preventing cancer using the isolated population of dendritic cells or pharmaceutical compositions. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623529 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class C12N 2501/02 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/052 (20130101) C12N 2501/52 (20130101) C12N 2501/999 (20130101) C12N 2501/2301 (20130101) C12N 2501/2304 (20130101) C12N 2501/2306 (20130101) C12N 2502/1114 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263159 | Berger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shelley L. Berger (Wayne, Pennsylvania); E. John Wherry (Havertown, Pennsylvania); Junwei Shi (Philadelphia, Pennsylvania); Zeyu Chen (Medford, Massachusetts); Zhen Zhang (Philadelphia, Pennsylvania); Rahul M. Kohli (Penn Valley, Pennsylvania); Jared B. Parker (Elkton, Maryland); Amy Elizabeth Baxter (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides compositions and methods for in vitro and in vivo gene editing using a cell penetrating CRISPR-Cas system comprising a cell penetrating Cas and an endosomal escape peptide. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566410 |
| CURRENT CPC | Peptides C07K 2319/06 (20130101) C07K 2319/09 (20130101) C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263173 | Fraser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Hunter B. Fraser (Stanford, California); Bin Zhao (Stanford, California); Shi-An Anderson Chen (Stanford, California) |
| ABSTRACT | The disclosure provides compositions and methods for high-efficiency genome editing in mammals. In some aspects, the disclosure provides guide RNA-retron cassettes, RNA-guided nuclease (e.g., Cas9)-reverse transcriptase fusion protein encoding cassettes, and vectors comprising the cassettes. Also provided are mammalian host cells that have been transfected with the vectors. In other aspects, guide-retron donor DNA molecules are provided. In some other aspects, methods for genome editing in mammals and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases and for other applications. Kits for genome editing and screening are also provided. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 18/682853 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2310/20 (20170501) C12N 2830/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263180 | TANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Qiyi TANG (Washington, District of Columbia); Hua ZHU (Newark, New Jersey) |
| ABSTRACT | The present disclosure provides small complementary RNAs (scRNAs), compositions containing the same, and methods for using such small complementary RNAs as antivirals. The present disclosure provides, in more specific embodiments, scRNAs that are single-stranded and which are about 20-30 nucleotides (nt) long, and which are complementary to the intron of an essential viral gene, such as the major immediate early (MIE) gene of human cytomegalovirus (HCMV). Also provided herein are pharmaceutical compositions additionally containing a pharmaceutically acceptable carrier system, wherein the carrier system includes a cationic polymer which releases the scRNA in response to endosomal pH. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/564938 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1131 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263184 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Abraham S. Weintraub (Cambridge, Massachusetts); Charles H. Li (Waban, Massachusetts); Alla A. Sigova (Newton, Massachusetts) |
| ABSTRACT | The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540829 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/113 (20130101) C12N 2015/859 (20130101) C12N 2310/51 (20130101) C12N 2310/53 (20130101) C12N 2830/001 (20130101) C12N 2830/15 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263192 | WILLENBRING et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Holger WILLENBRING (San Francisco, California); Laure DUMONT (San Francisco, California); Yann MALATO (San Francisco, California) |
| ABSTRACT | The present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected of having liver fibrosis. The disclosure also relates to methods in which recombinant virions, such as AAV virions, are introduced into the myofibroblasts of the liver and to deliver therapeutic nucleic acids, including those nucleic acids necessary to differentiate a myofibroblast into a hepatocyte, thereby not only improving liver function but also reducing collagen deposition and thus liver fibrosis. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/23 (20130101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263193 | Marzilli et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Alexander Michael Marzilli (Cambridge, Massachusetts); John Tuan Ngo (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to compositions, kits, systems and methods related to an engineered, inducible adenosine deaminase (iAD) enzymes, including but not limited to, an engineered inducible adenosine deaminase acting on RNA (ADAR) enzyme, which can be activated in the presence of an inducer. Also described are synthetic RNA molecules, to which the iAD can be specifically recruited to edit at least one target codon, leading to decreased or increased translation of the RNA molecules depending on the specific construct. The technology described herein is also directed to systems comprising the iAD and synthetic RNA molecule, nucleic acids and vectors encoding the iAD and synthetic RNA molecule, and methods of using such systems, nucleic acids, and vectors. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392928 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/87 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2795/18022 (20130101) Enzymes C12Y 305/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263205 | TRAVIS |
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| FUNDED BY |
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| APPLICANT(S) | Cornell Research Foundation, Inc. (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander TRAVIS (Ithaca, New York) |
| ABSTRACT | The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358637 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263214 | CHIU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| INVENTOR(S) | Daniel T. CHIU (Seattle, Washington); Jason E. KREUTZ (Seattle, Washington); Gloria S. YEN (Seattle, Washington); Bryant S. FUJIMOTO (Seattle, Washington) |
| ABSTRACT | Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/581760 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 21/47 (20130101) G01N 21/6428 (20130101) G01N 2015/1445 (20130101) G01N 2021/6439 (20130101) Image Data Processing or Generation, in General G06T 7/62 (20170101) G06T 2207/10056 (20130101) G06T 2207/30072 (20130101) Image or Video Recognition or Understanding G06V 20/695 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263230 | Drmanac et al. |
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| FUNDED BY |
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| APPLICANT(S) | Complete Genomics, Inc (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoje Drmanac (Los Altos Hills, California); Matthew J. Callow (Redwood City, California); Snezana Drmanac (Los Altos Hills, California); Brian K. Hauser (Campbell, California); George Yeung (Mountain View, California) |
| ABSTRACT | Random arrays of single molecules are provided for carrying out large scale analyzes, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm2 and have nearest neighbor distances that permit optical resolution of on the order of 109 single molecules per cm2. Many analytical chemistries can be applied to random arrays of the invention, including sequencing by hybridization chemistries, sequencing by synthesis chemistries, SNP detection chemistries, and the like, to greatly expand the scale and potential applications of such techniques. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/592843 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 1/047 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2525/151 (20130101) C12Q 2525/313 (20130101) C12Q 2531/125 (20130101) C12Q 2565/513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1434 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) Y10S 977/778 (20130101) Y10S 977/789 (20130101) Y10S 977/792 (20130101) Y10S 977/882 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263231 | Vogelstein et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Nickolas Papadopoulos (Towson, Maryland); Isaac A. Kinde (Beaumont, California) |
| ABSTRACT | The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells. |
| FILED | Friday, March 22, 2024 |
| APPL NO | 18/613979 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2563/179 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263235 | Mahnke et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amanda Mahnke (Bryan, Texas); Rajesh Miranda (Bryan, Texas); Ludmila Bakhireva (Los Ranchos, New Mexico) |
| ABSTRACT | The present invention relates to the discovery of miRNAs which can be isolated from the blood of neonates, especially the umbilical cord and/or placental blood of neonates which have been determined to be biomarkers for neonatal opioid withdrawal syndrome (NOWS). One or more of these biomarkers, often at least three in conjunction may be measured in the blood, preferably the cord or placental blood of neonates suspected of having opioid withdrawal syndrome and compared with a standard wherein the measurement of the one or more biomarkers evidences the presence of opioid syndrome in the neonate whose blood has been measured so that effective measures can be taken to treat, the withdrawal syndrome and inhibit, limit and/or reverse withdrawal syndrome in the neonate shortly after birth. In an embodiment, the cord and/or placental blood of an unborn neonate may be obtained and analyzed for opioid withdrawal syndrome, in an embodiment, one or more biomarkers as identified herein may be utilized to determine the effectiveness of therapy by measuring the biomarker at more than one time during a period of therapy for opioid withdrawal syndrome to determine if the concentration of biomarker has normalized to levels closer to that of a standard. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 18/012839 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263237 | Sette et al. |
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| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California) |
| ASSIGNEE(S) | La Jolla Institute for Immunology (La Jolla, California) |
| INVENTOR(S) | Alessandro Sette (La Jolla, California); Cecilia Lindestam Arlehamn (La Jolla, California) |
| ABSTRACT | This disclosure provides methods for determining whether a subject is suffering from a neurodegenerative disease, and/or methods of treating a neurodegenerative disease. The disclosed methods comprise detecting differential expression one or more genes or gene products from a sample obtained from the subject. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/564599 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263239 | Zhao |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keji Zhao (Kensington, Maryland) |
| ABSTRACT | Compositions and methods for determining and identifying both chromatin occupancy and transcriptome simultaneously in the same single cell. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 18/036392 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1264 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6841 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263252 | Monaghan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean F. Monaghan (East Greenwich, Rhode Island); Gerard J. Nau (Sharon, Massachusetts) |
| ABSTRACT | Blood and lung infections are a worldwide health problem with approximately five million deaths each year. Early treatment could help save lives, but better tests to identify these infections are needed. This invention identifies pathogens, particularly those that are resistant to antibiotics, faster. This invention allows for appropriate antibiotic treatment at an earlier time point. Data from deep RNA sequencing of human blood is used to create a faster diagnostic test for infections and associated antimicrobial resistance. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528750 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263254 | Langelier et al. |
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| FUNDED BY |
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| APPLICANT(S) | CZ Biohub SF, LLC (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles R. Langelier (Pacifica, California); Eran Mick (San Fransisco, California); Jack Albright (San Francisco, California); Angela Oliveira Pisco (San Francisco, California); John A. Kamm (San Francisco, California) |
| ABSTRACT | Provided herein are lists of combined host-viral gene markers that can be used for identifying COVID-19 in a subject and/or determining severity of disease. The host-viral diagnostic methods, compositions and systems disclosed herein are used to classify human subjects pre-diagnosis, with or without symptoms of COVID-19, based on the expression levels of the identified gene markers. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 18/569144 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Original (OR) Class C12Q 1/6809 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264151 | WHERRY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | E. John WHERRY (Havertown, Pennsylvania); Bertram BENGSCH (Freiburg, Germany); Omar KHAN (San Francisco, California); Jennifer WU (Philadelphia, Pennsylvania); Josephine GILES (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof. |
| FILED | Wednesday, January 03, 2024 |
| APPL NO | 18/403429 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6869 (20130101) C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 33/5091 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264152 | Muotri et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alysson Renato Muotri (La Jolla, California); Priscilla Davidson Negraes (San Diego, California); Cleber Trujillo (San Diego, California); Pinar Mesci (Carlsbad, California) |
| ABSTRACT | The disclosure provides methods of making functional cortical organoids from somatic cells and stem cells and methods of using the functional organoids. |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378530 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/5058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264154 | Walt et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Walt (Boston, Massachusetts); Connie Wu (Boston, Massachusetts); Richard Novak (Cambridge, Massachusetts); Tyler Dougan (Boston, Massachusetts); Rushdy Ahmad (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides ultrasensitive methods for detection and quantification of target analytes in samples. The methods can be multiplexed to allow simultaneous detection and quantification of multiple target analytes. The methods can achieve an attomolar limit of detection. The invention also provides related compositions and kits. |
| FILED | Wednesday, March 27, 2024 |
| APPL NO | 18/618019 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/54326 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264163 | BOYDEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward BOYDEN (Cambridge, Massachusetts); Adam Henry MARBLESTONE (Cambridge, Massachusetts); Samuel Gordon RODRIQUES (Cambridge, Massachusetts) |
| ABSTRACT | The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415295 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 2333/948 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264167 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AmberGen, Inc. (Billerica, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590471 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264168 | MESSMER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Abreos Biosciences, Inc. (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley T. MESSMER (San Diego, California); Dina UZRI (San Diego, California); Jessie-Farah FECTEAU (San Diego, California) |
| ABSTRACT | Methods and assays for detecting natalizumab in a sample, natalizumab-peptide complexes in a sample, and point-of-care devices for detecting natalizumab in a sample are described herein. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404461 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264172 | Rawls et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | John F. Rawls (Durham, North Carolina); James E.N. Minchin (Edinburgh, United Kingdom) |
| ABSTRACT | This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/414438 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) A61K 38/28 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264176 | Larsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Creighton University (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Larsen (Minneapolis, Minnesota); Tiffany M. Wolf (Minneapolis, Minnesota); Marc D. Schwabenlander (Minneapolis, Minnesota); Jason C. Bartz (Omaha, Nebraska); Qi Yuan (Omaha, Nebraska) |
| ABSTRACT | This document provides methods and materials for detecting misfolded poly peptides. For example, devices (e.g., feeding devices) designed to collect samples from one or more mammals (e.g., one or more cervids) are provided. In some cases, methods and materials that can be used to detect one or more prion diseases (e.g., chronic wasting disease (CWD)) in a population of mammals (e.g., a herd of cervids) based, at least in part, on the presence or absence of misfolded polypeptides in a sample from one or more mammals that was obtained from a feeding device are provided. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/567172 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2001/4094 (20130101) G01N 2800/2828 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240265996 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Cambridge, Massachusetts); Jeffrey R. Moffitt (Cambridge, Massachusetts); Junjie George Hao (Cambridge, Massachusetts); Tian Lu (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for imaging or determining nucleic acids or other desired targets, for instance, within cells or tissues. In one aspect, a sample is exposed to a plurality of nucleic acid probes that are determined within the sample. In some cases, however, background fluorescence or off-target binding may make it more difficult to determine properly bound nucleic acid probes. Accordingly, other components of the samples that may be contributing to the background, such as proteins, lipids, and/or other non-targets, may be “cleared” from the sample to improve determination. However, in certain embodiments, nucleic acids or other desired targets may be prevented from also being cleared, e.g., using polymers or gels within the sample. Other aspects are generally directed to compositions or kits involving such systems, methods of using such systems, or the like. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391977 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6841 (20130101) C12Q 2537/143 (20130101) C12Q 2543/10 (20130101) C12Q 2563/107 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266013 | BHAVE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in The City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shreyas BHAVE (New York, New York); Adler PEROTTE (New York, New York) |
| ABSTRACT | Modeling exemplary EHR data can be useful in a broad range of applications including prediction of future conditions or building latent representations of patient history. Exemplary embodiments of the present disclosure can model the full longitudinal history of a patient using a generative multivariate point process that (optionally simultaneously) can, e.g., (1) model irregularly sampled events probabilistically without discretization or interpolation; (2) have a closed-form likelihood, making training straightforward; (3) encode dependence between times and events with an approach inspired by competing risk models; and (4) facilitate a direct sampling. The exemplary embodiments can provide an improved performance on next-event prediction compared to existing approaches. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417066 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266036 | Chennubhotla et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Srinivas C. Chennubhotla (Pittsburgh, Pennsylvania); Filippo Pullara (Pittsburgh, Pennsylvania); Samantha A. Furman (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data to create segmented multi-parameter cellular and sub-cellular imaging data, and performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes. The recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/625784 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/23 (20230101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266382 | MUKHERJEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York) |
| INVENTOR(S) | Atreyo MUKHERJEE (Stony Brook, New York); Wei ZHAO (East Setauket, New York); Amirhossein GOLDAN (Stony Brook, New York); Le Thanh Triet HO (Centereach, New York); Anthony R. LUBINSKY (Port Jefferson, New York); Adrian HOWANSKY (Centereach, New York); Jann STAVRO (Stony Brook, New York); D. Peter SIDDONS (Upton, New York); Abdul Khader RUMAIZ (Nesconset, New York) |
| ABSTRACT | A solid-state photomultiplier with a high-k dielectric hole blocking layer (HBL) is provided. The HBL may include a n-type material. The photomultiplier may comprise an amorphous selenium (a-Se) bulk layer. The HBL may be a non-insulating layer. The photomultiplier may also comprise an electron blocking layer (EBL). The EBL may comprise a p-type material. The p-type material may also have a high k dielectric. The a-Se layer may be sandwiched between the HBL and the EBL. Methods for manufacturing a solid-state photomultiplier are also provided. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/561840 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14665 (20130101) Original (OR) Class H01L 27/14692 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267213 | Guan et al. |
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| FUNDED BY |
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| APPLICANT(S) | NTT Research, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT Research, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Jiaxin Guan (New York, New York); Daniel Wichs (Boston, Massachusetts); Mark Zhandry (New York, New York) |
| ABSTRACT | The present disclosure relates to a computerized method and system for message encryption in a multi-user setting. The method involves receiving a message of arbitrary length for each user, storing the message in a computerized data store, and executing a setup to generate a master secret and public keys. A random variable is generated, and a function is defined based on this variable. A second secret is derived using a functional encryption scheme, resulting in a derived secret. The message is encrypted by generating a first random string, a second partially random string, and a ciphertext. The system also includes a method for decrypting the encrypted message, processing the derived secret and ciphertext to derive a string, and deriving a plaintext message from this string. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/437215 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) H04L 9/0869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240261082 | Wilson et al. |
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| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (Castro Valley, California); Duncan J. Maitland (College Station, Texas); Ward Small, IV (Livermore, California); Patrick R. Buckley (Alameda, California); William J. Benett (Livermore, California); Jonathan Hartman (Sacramento, California); David Saloner (San Rafael, California) |
| ABSTRACT | A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406467 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1214 (20130101) A61B 17/12022 (20130101) A61B 17/12031 (20130101) A61B 17/12113 (20130101) A61B 17/12118 (20130101) A61B 17/12181 (20130101) A61B 2017/00867 (20130101) A61B 2017/00871 (20130101) A61B 2017/1205 (20130101) A61B 2017/12054 (20130101) A61B 2017/12072 (20130101) A61B 2017/12077 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/06 (20130101) Original (OR) Class A61F 2/82 (20130101) A61F 2/95 (20130101) A61F 2002/823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261718 | Dess et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ivy Capture Inc. (San Jose, California) |
| ASSIGNEE(S) | Ivy Capture Inc. (San Jose, California) |
| INVENTOR(S) | Peter Colin Dess (San Jose, California); Jaya Rao (San Jose, California); James Kronik (San Jose, California); Rene Alejandro Mendez (San Jose, California) |
| ABSTRACT | In variants, an air treatment module can include a sorption module defining a sorption cavity, an air intake channel, an air exhaust channel, and a target substance exhaust channel. The air treatment module can include a sorbent encapsulated within a sorbent structure (e.g., microencapsulated carbon sorbent) which can sorb carbon dioxide from air passing through the sorption cavity. The air treatment module can desorb carbon dioxide from the air and store the carbon dioxide in long term storage. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435339 |
| CURRENT CPC | Separation B01D 53/14 (20130101) B01D 53/62 (20130101) B01D 53/265 (20130101) B01D 53/268 (20130101) B01D 53/0438 (20130101) Original (OR) Class B01D 53/0454 (20130101) B01D 53/1475 (20130101) B01D 2252/00 (20130101) B01D 2253/25 (20130101) B01D 2253/102 (20130101) B01D 2257/504 (20130101) B01D 2259/4009 (20130101) B01D 2259/4508 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261720 | Long et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jeffrey R. Long (Berkeley, California); Benjamin E. R. Snyder (Champaign, Illinois); Ari B. Turkiewicz (Berkeley, California); Hiroyasu Furukawa (Berkeley, California); Maria V. Paley (Berkeley, California); Ever O. Velasquez (Berkeley, California); Matthew N. Dods (Berkeley, California) |
| ABSTRACT | A porous metal-organic framework M(dicarboxylate), where M=a divalent transition metal ion or alkaline earth metal ion, and (dicarboxylate)=a dicarboxylate linker with a layered two-dimensional structure with paddlewheel-type metal nodes forming a three-dimensional structure with rhombic channels along a c axis. The M(dicarboxylate) family of frameworks, where M=Cu, Fe, Cr, Mg, Ca, Mn, Co, Ni, Zn, Mo or Cd and (dicarboxylate)=trans-1,4-cyclohexanedicarboxylate, 1,4-benzenedicarboxylate, 4,4′-biphenyldicarboxylate, or 2,3,5,6-tetrafluorobenzenedicarboxylate, reversibly binds ammonia via cooperative insertion into its metal-carboxylate bonds to form a dense, one-dimensional coordination polymer that has rapid adsorption kinetics, a comparatively large working capacity and minimal expansion upon ammonia capture. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434724 |
| CURRENT CPC | Separation B01D 53/0462 (20130101) Original (OR) Class B01D 2253/204 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/024 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 11/005 (20130101) C07F 15/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261757 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Board of Trustees of Northern Illinois University (DeKalb, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Tao XU (Naperville, Illinois) |
| ABSTRACT | The present disclosure relates to a composition that includes a metal-sequestering material and a support material, where the composition is substantially transparent to light having a wavelength greater than or equal to 350 nm, the composition is in the form of a layer having a thickness between 0.1 μm and 1 mm, the metal-sequestering material is capable of absorbing a metal that includes at least one of a post-transition metal, a metalloid, an alkali metal, and/or an alkaline earth metal, and the metal-sequestering material has an absorption capacity for the metal between about 1E-2 g metal/cm2 and about 1E-7 g metal/cm2. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 18/292992 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/22 (20130101) Original (OR) Class B01J 20/261 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/032 (20130101) H01L 31/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261774 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Sangwoo LEE (Cohoes, New York); Chulsung BAE (Cohoes, New York); Musashi J. BRIEM (Troy, New York); Sungmin PARK (Troy, New York) |
| ABSTRACT | The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594586 |
| CURRENT CPC | Separation B01D 61/44 (20130101) B01D 71/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/07 (20170101) Original (OR) Class B01J 41/14 (20130101) B01J 47/12 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/469 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/32 (20130101) C08F 2810/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2287 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261858 | GHOTKAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rhushikesh GHOTKAR (Tempe, Arizona); Ryan MILCAREK (Gilbert, Arizona); Ivan ERMANOSKI (Tempe, Arizona); James MILLER (Albuquerque, New Mexico); Roy HOGAN, JR. (Albuquerque, New Mexico) |
| ABSTRACT | The disclosure concerns reactors for reducing metal oxide particles comprising: (a) a vertical heated channel; (b) a plurality of inclined, vertically stacked metal meshes, said meshes comprising: (i) a particle opaque portion comprising over about 50% of the meshes' length and having openings smaller than the smallest particle; and (ii) a particle transparent portion having openings large enough for particles to pass to the next level; (c) a vibration motor coupled to the meshes; and (d) an insulated chamber for storing the particles. Other aspects of the disclosure concern methods of reducing metal oxide particles. Yet other aspects concern thermochemical energy storage reactor devices comprising such reactors. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/385905 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/20 (20130101) Original (OR) Class B22F 2201/02 (20130101) B22F 2202/01 (20130101) B22F 2203/11 (20130101) B22F 2304/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261863 | Hildreth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen J. Hildreth (Lakewood, Colorado); Subbarao Raikar (Golden, Colorado) |
| ABSTRACT | A process is provided to remove a selective amount of material from a metal part fabricated by additive manufacturing in a self-terminating manner. The process can be used to remove support structures and trapped powder from a metal part as well as to smooth surfaces of a 3D printed metal part. In one embodiment, selected surfaces of the metal part are treated to make the selected surfaces at least one of mechanically and chemically unstable. The unstable portion of the metal support can then be removed chemically, electrochemically, with a pressure differential, and/or through vapor-phase etching. In one embodiment, the metal part may comprise one or more of an aluminum alloy, a titanium alloy, and a copper alloy. The process can be used to modify any fluid or vapor-accessible regions and surfaces of a 3D printed metal part. |
| FILED | Thursday, March 14, 2024 |
| APPL NO | 18/605755 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/43 (20210101) Original (OR) Class B22F 10/62 (20210101) B22F 10/64 (20210101) B22F 2301/10 (20130101) B22F 2301/052 (20130101) B22F 2301/205 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262523 | Terwilliger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RTX CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil J. Terwilliger (Cheshire, Connecticut); Joseph B. Staubach (Colchester, Connecticut) |
| ABSTRACT | A propulsion system for an aircraft includes a gas generating core engine, a propulsor that is driven by an exhaust gas flow that is generated by the core engine, and an inlet assembly where an inlet airflow is communicated to the core engine. The inlet assembly is disposed aft of the core engine and includes a turning duct that directs inlet air into the core engine, and a particle exhaust outlet that directs particulates away from the core engine. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405712 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 33/02 (20130101) Original (OR) Class B64D 33/04 (20130101) B64D 2033/0286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262707 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Alvin Dai (Bolingbrook, Illinois); Tongchao Liu (Westmont, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | A cathode active material includes a plurality of cathode active particles, each particle being of a composition expressed as: [Li1+γ(NixMnyCoz)1−γO2]αM1[Li1+δ(Nix′Mny′Coz′)1−δO2]βM2[Li1+ε(Nix″Mny″Coz″)1−εO2]1-α-βM3; or [Na1+γ(NixMnyCoz)1−γO2]αM1[Na1+δ(Nix′Mny′Coz′)1−δO2]βM2[Na1+ε(Nix″Mny″Coz″)1−εO2]1-α-βM3; wherein: M1 is a structure having a layered phase; M2 has structure comprising a Mn-rich and/or spinel phase; M3 has a rock salt or disordered rock salt phase; M1, M2, and M3 have different formulae; an inner most core portion of the particle is one of M1, M2, or M3; an interlayer may be any one of the remaining two of M1, M2, or M3; an outer most layer may be the remaining member of M1, M2, or M3; 0≤α<1, 0<β<1, −0.1≤γ≤0.1, −0.3≤δ≤0.3, −0.5≤ε≤0.5, 0≤x≤1, 0≤y≤0.5, 0≤z≤1, 0≤x′≤0.5, 0.5≤y′≤1, 0≤z′≤0.5, and 0≤x″≤1, 0≤y″≤1, 0≤z″≤1; and the sum of x, y and z is 1, the sum of x′, y′ and z′ is 1, and the sum of x″, y″, and z″ is 1. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105469 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/006 (20130101) Original (OR) Class C01G 53/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262750 | Pyatina et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (UPTON, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tatiana Pyatina (Stony Brook, New York); Toshifumi Sugama (Wading River, New York) |
| ABSTRACT | In one aspect, the disclosure relates to calcium-free aluminum-based cement formulations designed for applications under supercritical conditions and in corrosive environments. In an aspect, alkali activation of aluminum hydroxide at high temperatures leads to the formation of mineral phases stable under supercritical and superhot conditions. In another aspect, these include, but are not limited to, crystalline phases of boehmite and paragonite and, optionally, a minor vlasovite phase. In yet another aspect, the compositions and articles made therefrom, such as geothermal well sheaths, are stable under the extreme conditions, and water-fillable porosity and mechanical properties of these cement formulations persist through super-critical exposure. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432615 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/024 (20130101) C04B 14/026 (20130101) C04B 14/045 (20130101) C04B 14/306 (20130101) C04B 28/04 (20130101) C04B 28/06 (20130101) Original (OR) Class C04B 28/34 (20130101) C04B 40/0071 (20130101) C04B 40/0082 (20130101) C04B 2111/2084 (20130101) C04B 2201/32 (20130101) C04B 2201/50 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/467 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262765 | Lewicki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Lewicki (Oakland, California); Michael J. King (Livermore, California); Nicholas Hanson Loey (Livermore, California) |
| ABSTRACT | A product includes a three-dimensional scaffold structure having an open cell geometry with interconnected channels for allowing continuous communication throughout a volume of the scaffold structure. The scaffold structure is configured to enhance mechanical strength of an energetic material. A fuel material is present in the scaffold structure and/or a second material is coupled to the scaffold structure. The fuel material is configured to increase an output of energy release relative to an output of energy release from the scaffold structure having the fuel material not present. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/106921 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2307/04 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0058 (20130101) C06B 29/00 (20130101) C06B 33/06 (20130101) C06B 45/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262839 | FLOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AMAR HUGH FLOOD (bLOOMINGTON, Indiana); JAMES ROBERT DOBSCHA (Bloomington, Indiana); INDIANA UNIVERSITY RESEARCH and TECHNOLOGY CORPORATION (Indianapolis, Indiana) |
| ASSIGNEE(S) | INDIANA UNIVERSITY RESEARCH and TECHNOLOGY CORPORATION (Indianapolis, Indiana) |
| INVENTOR(S) | Amar Hugh FLOOD (Bloomington, Indiana); James Robert DOBSCHA (Bloomington, Indiana) |
| ABSTRACT | The present disclosure concerns scalable single-pot synthesis, anion binding features, liquid-liquid extraction of salts of the triazolophane macrocycle of Formula (I): wherein the substituents R are independently selected from the group consisting of a linear and branched alkyl, a linear and branched alkyl substituted with an ionizable functional group such as an amine or carboxylic acid, a linear and branched alkoxy (R=—OR), an alkyl comprising —O(CH2CH2O)nCH3, where n is 1-20, an amide —CO—NR1R2, where R1 is any alkyl, organic substituent, R2 is any alkyl, organic substituent, wherein R1 and R2 may be identical or different, —OCO—R, wherein R is any alkyl, organic substituent, an aromatic ring and their substituted analogues, any length and sequence of natural and unnatural amino acids that make up a peptide chain, and —C≡C—R where R is any alkyl, organic substituent. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 18/104469 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/683 (20130101) C02F 2101/12 (20130101) Heterocyclic Compounds C07D 487/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263021 | Meredith, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia); CHITOZAN HEALTH LLC (Jacksonville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Carson Meredith, III (Marietta, Georgia); Austin VAN HORN (Jacksonville, Florida) |
| ABSTRACT | Disclosed are compositions comprising chitin nanofibers (ChNF) and silver chitosan (AgCh) and/or silver-copper chitosan (AgCuCh). Also disclosed are methods of coating various substrates with the disclosed compositions in order to impart antiviral and antimicrobial properties, as well as oxygen and water vapor barrier properties, to the substrate. Coated substrates made by the disclosed methods are also disclosed. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/567181 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 59/16 (20130101) A01N 59/20 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) Original (OR) Class C09D 105/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263063 | Muhich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christopher Muhich (Phoenix, Arizona); Jayni Hashimoto (Tempe, Arizona); Daniel Rivera (Mesa, Arizona); Harsheen Rajput (Miami, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Christopher Muhich (Phoenix, Arizona); Jayni Hashimoto (Tempe, Arizona); Daniel Rivera (Mesa, Arizona); Harsheen Rajput (Miami, Arizona) |
| ABSTRACT | High-temperature thermochemical energy storage materials using doped magnesium-transition metal spinel oxides are provided. -transition metal spinel oxides, such as magnesium manganese oxide (MgMn)3O4, are promising candidates for high-temperature thermochemical energy storage applications. However, the use of these materials has been constrained by the limited extent of their endothermic reaction. Embodiments described herein provide for doping magnesium-transition metal spinel oxides to produce a material of low material costs and with high energy densities, creating an avenue for plausibly sized modules with high energy storing capacities. |
| FILED | Saturday, March 09, 2024 |
| APPL NO | 18/600684 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/12 (20130101) C01G 45/1235 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/32 (20130101) C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2006/32 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263187 | Dixon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Dixon (Sulphur, Oklahoma); Fang Chen (Denton, Texas); Chunliu Zhuo (Denton, Texas) |
| ABSTRACT | The disclosure provides recombinant LAC polynucleotides encoding a laccase (LAC) polypeptide capable of polymerizing caffeyl alcohol, vectors and cells including the recombinant LAC polynucleotide. The disclosure also provides transgenic plants including cells having the recombinant LAC polynucleotide of the present disclosure and methods of increasing production of C-lignin in a plant. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594315 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263319 | Thorson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Michael R. Thorson (Richland, Washington); Uriah Kilgore (Richland, Washington); Udishnu Sanyal (Richland, Washington); Karthikeyan Kallupalayam Ramasamy (Richland, Washington) |
| ABSTRACT | Disclosed herein are embodiments of a system and method that combine carbon dioxide reduction and methanol oxidation to provide an efficient path to formaldehyde production. The system and method embodiments are designed to rely on methanol oxidation to formaldehyde to provide the electrons needed to drive carbon dioxide reduction to carbon monoxide. The carbon monoxide obtained by carbon dioxide reduction is converted to the methanol used in the system/method via hydrogenation. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 18/563223 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/07 (20210101) Original (OR) Class C25B 3/23 (20210101) C25B 3/26 (20210101) C25B 9/19 (20210101) C25B 11/046 (20210101) C25B 11/065 (20210101) C25B 15/083 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263578 | Sobanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon Erik Sobanski (Glastonbury, Connecticut); Jacob C. Snyder (East Haddam, Connecticut) |
| ABSTRACT | A propulsion system for an aircraft includes a core engine that generates a core gas flow, a propulsor section that is driven by the core engine and disposed aft of the core engine, a nacelle that surrounds the core engine and the propulsor section, a water recovery system that is disposed in the nacelle, an exhaust duct where the core gas flow is directed radially outward from the core engine to the nacelle, an evaporator assembly that is in thermal communication with the exhaust duct where water is recovered by the water recovery system and is heated to generate a steam flow that is subsequently communicated to the core engine. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/106161 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/22 (20130101) F02C 3/30 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/211 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264114 | Burge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Scott R. Burge (Tempe, Arizona); Russell G. Burge (Mountain View, California); David A. Hoffman (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Burge (Tempe, Arizona); Russell G. Burge (Mountain View, California); David A. Hoffman (Tempe, Arizona) |
| ABSTRACT | Methods and systems for monitoring microbial activity and microbial communication in an environment are disclosed. Exemplary methods include measuring a high impedance voltage between a reference electrode and one or more measurement electrodes to monitor microbial activity. Microorganisms form a biofilm that attaches to at least one of the one or more inert measurement electrodes and that allows for measuring the microbial activity, characterizing the environment, and/or monitoring microbial communication in the environment. |
| FILED | Tuesday, March 19, 2024 |
| APPL NO | 18/609730 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) G01N 27/4035 (20130101) G01N 27/4163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266078 | SHOUP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Jeffrey SHOUP (Delmont, Pennsylvania); Yuriy ALESHIN (Cayce, South Carolina); David M. GROSS (Gibsonia, Pennsylvania); Joshua J. DONOVAN (Cranberry, Pennsylvania); Jurie J. VAN WYK (Mars, Pennsylvania); Jeffrey M. PARKS (LaJose, Pennsylvania) |
| ABSTRACT | Disclosed is nuclear reactor fuel rod for use in a nuclear reactor. The nuclear reactor fuel rod comprises a sleeve defining a longitudinal axis. The sleeve includes a first end portion and a second end portion. The nuclear reactor fuel rod further includes a first end cap mechanically coupled to the first end portion of the sleeve and a second end cap mechanically coupled to the second end portion of the sleeve. The second end cap is configured to slide along the longitudinal axis relative to the sleeve. The nuclear reactor fuel rod further includes a fuel compact located inside of the sleeve between the first end cap and the second end cap. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/163415 |
| CURRENT CPC | Nuclear Reactors G21C 3/10 (20130101) G21C 3/14 (20130101) Original (OR) Class G21C 3/045 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266080 | Liszkai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TerraPower, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamas Liszkai (Bellevue, Washington); Jason Brian Meng (Redmond, Washington) |
| ABSTRACT | A nuclear reactor core includes a plurality of core assemblies. The core assemblies have a cooperating structure formed at one or more load pads that mechanically couple the plurality of core assemblies together to limit relative motion between core assemblies in a kinematically determinate way. A shear key on one core assembly is configured to fit in a tab slot on an adjacent core assembly. Motion of one core assembly is transferred to a second core assembly and the core assemblies move together. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531636 |
| CURRENT CPC | Nuclear Reactors G21C 5/16 (20130101) Original (OR) Class G21C 5/18 (20130101) G21C 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266084 | Moore |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TerraPower, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Moore (Kirkland, Washington) |
| ABSTRACT | In a sodium fast reactor, a bypass pipe is fluidly coupled to the primary sodium pump discharge and diverts a portion of the primary sodium coolant to an instrument assembly. The bypass pipe routes flowing sodium upward toward the reactor head where it fluidly couples to the instrument assembly. The instrument assembly includes an instrument tank and selectively swappable instrument modules. The instrument modules can be configured to measure flow, pressure, temperature, and fluid level, among other things. The instrument assembly is located relatively close to the reactor head and close to the sodium level in the sodium pool and is accessible from above the reactor head for quick and efficient removal and replacement of the entire instrument assembly or individual instruments. |
| FILED | Wednesday, December 06, 2023 |
| APPL NO | 18/531633 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 23/284 (20130101) Nuclear Reactors G21C 17/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266135 | Neubauer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Muons, Inc. (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael L. Neubauer (San Francisco, California); Alan J. Dudas (Alamo, California); Stephen A. Kahn (Commack, New York) |
| ABSTRACT | An anode structure for a magnetron provides for low eddy currents and efficient water cooling. The anode structure may be made by machining a bimetal blank including an out layer of a first metal and an inner layer of a second metal and formed by explosion bonding. The second metal has a resistivity lower than first metal and a thermal conductivity higher than the first metal. The machining may result in the anode structure with vanes each having a center (tip) portion made of the second metal and the rest made of the first metal. The machined anode structure may be coated with the second metal. |
| FILED | Friday, March 15, 2024 |
| APPL NO | 18/607130 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 9/02 (20130101) H01J 23/02 (20130101) Original (OR) Class H01J 25/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266382 | MUKHERJEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York) |
| INVENTOR(S) | Atreyo MUKHERJEE (Stony Brook, New York); Wei ZHAO (East Setauket, New York); Amirhossein GOLDAN (Stony Brook, New York); Le Thanh Triet HO (Centereach, New York); Anthony R. LUBINSKY (Port Jefferson, New York); Adrian HOWANSKY (Centereach, New York); Jann STAVRO (Stony Brook, New York); D. Peter SIDDONS (Upton, New York); Abdul Khader RUMAIZ (Nesconset, New York) |
| ABSTRACT | A solid-state photomultiplier with a high-k dielectric hole blocking layer (HBL) is provided. The HBL may include a n-type material. The photomultiplier may comprise an amorphous selenium (a-Se) bulk layer. The HBL may be a non-insulating layer. The photomultiplier may also comprise an electron blocking layer (EBL). The EBL may comprise a p-type material. The p-type material may also have a high k dielectric. The a-Se layer may be sandwiched between the HBL and the EBL. Methods for manufacturing a solid-state photomultiplier are also provided. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/561840 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14665 (20130101) Original (OR) Class H01L 27/14692 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266455 | TERAO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Maxeon Solar Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AKIRA TERAO (San Jose, California) |
| ABSTRACT | Metallization and stringing methods for back-contact solar cells, and resulting solar cells, are described. In an example, in one embodiment, a method involves aligning conductive wires over the back sides of adjacent solar cells, wherein the wires are aligned substantially parallel to P-type and N-type doped diffusion regions of the solar cells. The method involves bonding the wires to the back side of each of the solar cells over the P-type and N-type doped diffusion regions. The method further includes cutting every other one of the wires between each adjacent pair of the solar cells. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623950 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0504 (20130101) Original (OR) Class H01L 31/022441 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266527 | Gim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jihyeon Gim (Naperville, Illinois); Anil U. Mane (Naperville, Illinois); Jinhyup Han (Naperville, Illinois); Seoung-Bum Son (Naperville, Illinois); Pragathi Darapaneni (Lake Orion, Michigan); Eungje Lee (Naperville, Illinois); Khalil Amine (Oakbrook, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Jason R. Croy (Plainfield, Illinois); Rajesh Pathak (Westmont, Illinois) |
| ABSTRACT | A coated cathode material including high-nickel lithium cathode and a method of producing the same by atomic layer deposition. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/106227 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/0428 (20130101) H01M 4/0471 (20130101) H01M 4/485 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 2004/021 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266528 | Jafta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charl J. Jafta (Oak Ridge, Tennessee); Xiao-Guang Sun (Oak Ridge, Tennessee); M. Parans Paranthaman (Oak Ridge, Tennessee) |
| ABSTRACT | A method of activating an electrode material is provided. The method includes adding an ion-conducting salt to an organic solvent to obtain a salt solution. An electrode material is introduced to the salt solution to obtain a reaction mixture by heat treating. The reaction mixture is heat treated at a temperature in a range of 50 to 70° C. for a period of time to surface coat the electrode material with an inorganic compound to obtain an activated electrode material. The ion-conducting salt may be a metal bis(fluorosulfony)imide, the metal being selected from a group consisting of Li, Na, K, Zn, Mg, Al, and Fe. The time period may be at least 4 hours and may be in a range of 8 to 24 hours. The inorganic compound coated on the electrode material may be LiF. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432242 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/44 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/80 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/62 (20130101) H01M 4/366 (20130101) H01M 4/525 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266837 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Tillay Johnson (Albuquerque, New Mexico); Rachid Darbali-Zamora (Mayaguez, Puerto Rico); Adam Summers (Albuquerque, New Mexico); Clifford W. Hansen (Albuquerque, New Mexico) |
| ABSTRACT | Advanced Distribution Management Systems not generally optimize over the entire feeder because there are few high-fidelity distribution circuit models and real-time distribution-connected sensors are rare. The limited observability at the distribution level makes it difficult to globally optimize distribution operations and issue control setpoints to power systems equipment or Distributed Energy Resources (DER) to perform grid-support services. For example, setpoints can be issued to DER based on results from an optimization module that incorporates a static or time-series feeder simulation. Feeder simulation initial conditions are populated with photovoltaic (PV) and load forecasts, state estimation results, and/or digital twin measurements or state output. The real-time (RT) digital twin runs a model of the feeder to generate state estimation pseudo-measurements since there are limited live feeder measurements. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/418756 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/042 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) H02J 3/004 (20200101) H02J 3/381 (20130101) Original (OR) Class H02J 2203/20 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240268013 | Ebrahimi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Fatima Arezu Ebrahimi (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap. A total Lorentz force causes oppositely directed magnetic field lines to be expanded around a region of the gas injector to further create an azimuthal current in the form of an axially elongated current sheet that is unstable such that the axially elongated current sheet reconnects and breaks into plasmoids. |
| FILED | Tuesday, April 16, 2024 |
| APPL NO | 18/636858 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/06 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240268139 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haonan Zhao (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | An organic light emitting device comprises an anode and a cathode, an organic emissive layer positioned between the anode and the cathode, the organic emissive layer comprising a host material and a dopant, a host material layer positioned between the cathode and the organic emissive layer, and a charge transport layer positioned between the cathode and the host material layer, wherein the charge transport layer is configured to form plasmon exciton polaritons in a region between the cathode and the charge transport layer. Stacked devices are also disclosed. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413235 |
| CURRENT CPC | Organic electric solid-state devices H10K 50/12 (20230201) Original (OR) Class H10K 50/13 (20230201) H10K 50/15 (20230201) H10K 50/16 (20230201) H10K 50/856 (20230201) H10K 2101/10 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240268145 | QU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yue QU (Ann Arbor, Michigan); Xiaheng Huang (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method of fabricating a light emitting device comprises providing a mold having an unpolished surface with an arithmetic mean roughness Ra in a range from 0.1 μm to 10 μm, depositing a thin polymer film over the surface of the mold, wherein the film has a thickness in a range from 1 μm to 100 μm, positioning a light emitting body onto the thin polymer film, wherein the light emitting body includes an anode, a cathode, and a light emitting layer positioned between the anode and the cathode, and separating the thin polymer film with the light emitting body from the mold. A light emitting device is also described. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496126 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/02 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3475 (20130101) Organic electric solid-state devices H10K 50/11 (20230201) H10K 50/854 (20230201) Original (OR) Class H10K 71/00 (20230201) H10K 71/80 (20230201) H10K 71/821 (20230201) H10K 77/111 (20230201) H10K 2101/10 (20230201) H10K 2102/311 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240260939 | Hatlan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sonivate Medical, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Sonivate Medical, Inc. (Portland, Oregon) |
| INVENTOR(S) | James T. Hatlan (Portland, Oregon); Austen Angell (Portland, Oregon); William McDonough (Portland, Oregon) |
| ABSTRACT | Disclosed are wearable ultrasound probes for use in trauma triage and assessment. The probes include a housing having a dorsal side and a palmar side, a proximal end and a distal end, and a longitudinal axis extending therebetween. The proximal end comprises a finger-receiving aperture that is configured to form a sleeve including a tubular wall member formed from an elastomeric material and defining an inner lumen. A portion of the tubular wall member is configured to extend or project into the inner lumen to form a deformable gripping member for gripping a finger. The probes also include at least one ultrasound array disposed at the distal end or adjacent to the distal end. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623792 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4427 (20130101) A61B 8/4455 (20130101) Original (OR) Class A61B 8/4477 (20130101) A61B 8/4488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261805 | Karwoski, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Stanley Karwoski, JR. (Lusby, Maryland); John P. Farley (Burke, Virginia); Christopher Pfutzner (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein is an article used as a foam nozzle spreader tip. The article is brass or stainless steel and has a first surface, a hollow space removed from the first surface, first and second screw holes through the article and the first surface but not touching the hollow space, and a third screw hole through the article touching the hollow space. The hollow space has a half-cylinder region and a rounded trapezoidal prism region. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434547 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/042 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262773 | Palmese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania); Government of USA, by The Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania); Government of USA, by The Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Giuseppe R. Palmese (Hainesport, New Jersey); Emre Kinaci (Philadelphia, Pennsylvania); John J. LaScala (Wilmington, Delaware) |
| ABSTRACT | A polymerizable monomer prepared by reacting at least one epoxidized cardanol with (meth)acrylic anhydride or (meth)acryloyl chloride in the presence of one or more of triethylamine, tertiary amines, pyridines and pyridine derivatives; wherein the epoxidized cardanol is formed by epoxidation of an unsaturation site of a cardanol having the formula (I): wherein R is selected from hydrogen and an alkyl, or alkenyl group having 1-6 carbon atoms, and n is 7, 10, or 13, a polymer and resin made form the polymerizable monomer, and a method of preparing such a polymer. The resin created from this monomer is suitable for moderate temperature composites and coatings applications. |
| FILED | Wednesday, March 06, 2024 |
| APPL NO | 18/597606 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 39/19 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263136 | Cafri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Gal Cafri (Kibbutz Nir David, Israel); Paul F. Robbins (Chevy Chase, Maryland); Jared J. Gartner (Gaithersburg, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of preparing an isolated population of dendritic cells, isolated populations of dendritic cells prepared by the methods, and pharmaceutical compositions comprising the isolated population of dendritic cells. Also disclosed are methods of treating or preventing cancer using the isolated population of dendritic cells or pharmaceutical compositions. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623529 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class C12N 2501/02 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/052 (20130101) C12N 2501/52 (20130101) C12N 2501/999 (20130101) C12N 2501/2301 (20130101) C12N 2501/2304 (20130101) C12N 2501/2306 (20130101) C12N 2502/1114 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263361 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Mengmeng ZHANG (Dallas, Texas); Ray BAUGHMAN (Dallas, Texas); Shaoli FANG (Richardson, Texas); Jiyoung OH (Fort Worth, Texas); Zhong WANG (Dallas, Texas); Fatma GÖKTEPE (Istanbul, Turkey); Özer GÖKTEPE (Istanbul, Turkey) |
| ABSTRACT | Methods for fabricating coiled polymer fibers and yarns (high-spring-index coiled fibers and yarns). Methods include inserting twist separately into individual fibers or yarns, plying the fibers or yarns by inserting plying twist, setting the ply structure without permanently binding together the fibers or yarns of different plies so that the ply structure is substantially stable against untwist when torsionally untethered, and then unwrapping the plied fibers or yarns so that a high-spring-index fiber or yarn can be obtained. In some embodiments, the unwrapped fibers or yarns are further set so that these are further stabilized. The methods can eliminate the need for a mandrel, and can be quickly applied for applications where high-spring-index thermally-driven artificial muscles are presently employed, such as for presently commercialized comfort-adjusting jackets. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431022 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 1/028 (20130101) D02G 1/0286 (20130101) D02G 3/02 (20130101) D02G 3/12 (20130101) D02G 3/38 (20130101) D02G 3/448 (20130101) Original (OR) Class Finishing or Dressing of Filaments, Yarns, Threads, Cords, Ropes or the Like D02J 13/00 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 15/41 (20210101) D03D 15/49 (20210101) D03D 15/283 (20210101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2331/02 (20130101) D10B 2331/10 (20130101) D10B 2505/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06143 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263385 | Uddin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammed Jasim Uddin (Edinburg, Texas); Jared Jaksik (San Antonio, Texas); H. Justin Moore (Collinsville, Connecticut) |
| ABSTRACT | A method for forming a metallic nanoparticle and semiconductor coated surface, such as the surface of a fiber or other material is provided. The method can include the steps of coating at least one surface of a material, for example a textile material, with a semiconducting layer, and providing metallic nanoparticles on the semiconducting layer. The steps for coating a surface of a material with a semiconducting layer can include forming a titanium dioxide film on the surface of the textile or other material. The steps for depositing and/or providing metallic nanoparticles on the semiconducting layer can include immersing a surface having a semiconductor layer into a metallic nanoparticle precursor solution, drying the semiconductor layer, and exposing the semiconductor layer on the surface to UV radiation. The metallic nanoparticles can include gold and/or silver nanoparticles. Also disclosed are surface treated materials having a semiconductor layer thereon, wherein the semiconductor layer is treated to include metallic nanoparticles. The surface treated materials may comprise surfaces of a textile material, such as fibers. The surface treated materials are anti-microbial and resistant to peeling, as well as non-toxic to biological surfaces, such as skin. Treated fiber materials may be used in garments, masks, and other products that contact the skin, that are free of toxic/rash side effects. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639315 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1161 (20130101) A41D 13/1192 (20130101) A41D 31/30 (20190201) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/83 (20130101) Original (OR) Class D06M 16/00 (20130101) D06M 2101/06 (20130101) D06M 2200/00 (20130101) D06M 2200/01 (20130101) D06M 2400/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263903 | Lehr |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, Department of the Navy (Dahlgren, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew D. Lehr (King George, Virginia) |
| ABSTRACT | An apparatus for discharging a weapon includes a combination trigger that includes both a manual trigger and a remote trigger. The weapon may be discharged using either the manual trigger or remote trigger. The apparatus may also include a remote and/or manual safety to prevent the weapon from being discharged. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/449199 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 17/46 (20130101) F41A 17/063 (20130101) F41A 19/08 (20130101) F41A 19/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263944 | Moran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Kari Moran (San Diego, California); Kathryn Liotta (San Diego, California) |
| ABSTRACT | A multi-mode, mode-matched, mems-based Coriolis vibratory gyroscope. A vibratory gyroscope apparatus, comprising a resonating proof mass having a top surface and a plurality of side surfaces substantially perpendicular to the top surface, wherein the proof mass is configured to facilitate in-plane motion at a mode-matched frequency, a plurality of comb capacitors, each coupled to one of the plurality of side surfaces, and configured to provide an in-plane sense metric while operating at the mode-matched frequency, and a plurality of serpentine springs configured to facilitate translational motion of the proof mass in directions substantially perpendicular to the top surface. Additionally, the apparatus may further comprise a gyroscope controller configured to receive, measure, and/or adjust the control signal for a plurality of sense modes, an actuator electrically coupled to the proof mass, and a plurality of electrodes each electrically coupled to each of the plurality of comb capacitors. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/164739 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5614 (20130101) G01C 19/5712 (20130101) Original (OR) Class G01C 19/5783 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264113 | De Keersmaecker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel De Keersmaecker (Tucson, Arizona); Erin L. Ratcliff (Tucson, Arizona); Neal R. Armstrong (Tucson, Arizona) |
| ABSTRACT | An apparatus for characterizing a substructure of a semiconductor device includes a potentiostat; a counter electrode electrically connected to the potentiostat; a solid electrolyte attached to a surface of the counter electrode; a reference electrode embedded within at least a portion of the solid electrolyte and electrically connected to the potentiostat; and a probe electrically connected to the potentiostat. The solid electrolyte includes a solid porous material and an ionic liquid disposed within the solid porous material. A method of characterizing a substructure of a semiconductor device includes contacting at least a portion of a surface of the substructure of the semiconductor device with a second surface of a solid electrolyte. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/567985 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/301 (20130101) G01N 27/406 (20130101) G01N 27/3335 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264177 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BANYAN BIOMARKERS, INC. (Durham, North Carolina) |
| ASSIGNEE(S) | BANYAN BIOMARKERS, INC. (Durham, North Carolina) |
| INVENTOR(S) | Kevin Ka-Wang WANG (Gainesville, Florida); Ronald L. HAYES (Alachua, Florida); Uwe R. MUELLER (Alachua, Florida); Zhiqun ZHANG (Auburndale, Massachusetts) |
| ABSTRACT | A robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The method includes measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/637770 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/28 (20130101) G01N 2800/52 (20130101) G01N 2800/56 (20130101) G01N 2800/60 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264255 | Solmeyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Neal Eldrich Solmeyer (Edina, Minnesota); Matthew Wade Puckett (Phoenix, Arizona); Matthew Robbins (Minneapolis, Minnesota); Jianfeng Wu (Tucson, Arizona); Mary Salit (Plymouth, Minnesota) |
| ABSTRACT | Systems for an integrated photonic responsive material sensor are described herein. In certain embodiments, a system includes a carrier wafer that includes a cavity formed in the carrier wafer. The carrier wafer also includes a responsive waveguide coupled to the cavity, the responsive waveguide formed from responsive material responsive to a force by shifting a resonance frequency of point defects in the responsive material in response to the force, wherein a pump light is directed to the responsive waveguide to prepare the responsive waveguide to absorb a probe light when exposed to a radio frequency at the point defect resonance frequency. Additionally, the system includes components coupled to the carrier wafer, wherein the components include a probe light source that generates the probe light, wherein the components are positioned in relation to the carrier wafer to couple the probe light into the cavity. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/165894 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) G01R 33/345 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264391 | WOOD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AirBorn Inc. (Georgetown, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance A. WOOD (Winter Park, Colorado); Harsha Krishna KOPURU (Parker, Colorado); Rebekah Jean MITCHELL (Littleton, Colorado); Jason Paul SMITH (Sartell, Minnesota); Timothy John WASLAND (Little Falls, Minnesota) |
| ABSTRACT | A space active optical cable (SAOC) includes a cable including one or more optical fibers, and two or more electrical transceivers on opposing ends of the cable and interconnected by the cable. Each of the electrical transceivers includes an enclosure that encloses one or more light sources, one or more light detectors, and control electronics. Also included in the enclosure are a coupling medium to couple light into and out of the one or more optical fibers. The coupling medium can be reflecting surface or an on-axis mount. The enclosure provides a suitable heat propagation and electromagnetic interference (EMI) shielding, and the cable and the two or more electrical transceivers are radiation resistant. SAOC features optionally support a health check algorithm that allows trending optical performance in the absence of an optical connector and a potential surface treatment to increase nominally low emissivity of an EMI conductive surface. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/617647 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/428 (20130101) G02B 6/4206 (20130101) G02B 6/4214 (20130101) G02B 6/4246 (20130101) Original (OR) Class G02B 6/4267 (20130101) G02B 6/4277 (20130101) G02B 6/4284 (20130101) G02B 6/4286 (20130101) G02B 6/4415 (20130101) Transmission H04B 10/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264669 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICAS AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio); UNITED STATES OF AMERICAS AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| INVENTOR(S) | Michael E. Miller (XENIA, Ohio); BRETT J. BORGHETTI (BEAVERCREEK, Ohio); KELLIE D. KENNEDY (POQUOSON, Virginia); CHAD L. STEPHENS (POQUOSON, Virginia); ALAN T. POPE (POQUOSON, Virginia) |
| ABSTRACT | A brain-computer interface system includes a video processor for producing a display signal, a temporal controller for producing a plurality of repetitive visual stimulus (RVS) signals with different respective temporal aspects, a display device that receives the display signal and displays a corresponding image on a plurality of different display regions and receives the RVS signals and displays corresponding RVS in respective ones of the display regions, an electroencephalographic (EEG) sensor for sensing a visually-evoked cortical potential (VECP) signal in a user with eyes fixated on a viewed one of the display regions, and a VECP processor for processing the VECP signal to identify the respective temporal aspect of the respective RVS of the viewed display region to estimate the eye fixation location. The RVS are generated independently of the display update/refresh rate and at sufficiently high frequencies to avoid flicker perceptible to the user. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/104913 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/013 (20130101) G06F 3/015 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 5/005 (20130101) G09G 2340/0435 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240265266 | Camus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore Camus (Marlton, New Jersey); Zachary Seymour (Pennington, New Jersey); Bhoram Lee (Princeton, New Jersey); Andrew C. Silberfarb (Oceanside, California); Supun Samarasekera (Skillman, New Jersey); Jonathan Brookshire (Princeton, New Jersey) |
| ABSTRACT | In general, techniques are described for coordinating actions of a plurality of agents or subsystems using a machine learning system that implements a Capability Graph Network (CGN). In an example, a method includes generating a control policy model comprising a plurality of nodes and a plurality of edges interconnecting the plurality of nodes, wherein the plurality of nodes represents a plurality of agents or subsystems and the plurality of edges represent information exchange between the plurality of agents or subsystems; and encoding agent behavior control policy within the control policy model for executing to coordinate a plurality of the actions of the plurality of agents or subsystems. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434435 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/042 (20230101) G06N 3/092 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240265694 | Lal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Lal (Ithaca, New York); Yutong Liu (Ithaca, New York); Juneho Hwang (Ithaca, New York); Justin Kuo (Ithaca, New York) |
| ABSTRACT | An ultrasonic computation apparatus includes first and second ultrasonic transducer arrays arranged on opposing ends thereof, and further comprises first and second ultrasonic propagation regions arranged between the first and second ultrasonic transducer arrays and proximate respective ones of the first and second ultrasonic transducer arrays, and an intermediate computational structure arranged between the first and second ultrasonic propagation regions. Respective first and second input signals applied to respective ones of the first and second ultrasonic transducer arrays cause propagation of corresponding ultrasonic waves through the respective first and second ultrasonic propagation regions towards the intermediate computational structure. The intermediate computational structure is configured to receive the propagating ultrasonic waves from the respective first and second ultrasonic propagation regions and to generate from the received propagating ultrasonic waves an additional signal that is a function of the first and second signals. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/282141 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/955 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266165 | Nakamura et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Shuji Nakamura (Santa Barbara, California); Steven P. DenBaars (Goleta, California) |
| ABSTRACT | A III-V or II-VI compound based device is fabricated having one or more layers with an in-plane lattice constant or strain that is at least 20% biaxially relaxed, preferably more than 20% biaxially relaxed, more preferably 50% or more biaxially relaxed, and most preferably at least 70% biaxially relaxed. A III-V or II-VI compound based decomposition stop layer is created on or above a III-V or II-VI compound based decomposition layer, wherein the III-V or II-VI compound based decomposition stop layer has a higher sublimation temperature or melting point as compared to a lower sublimation temperature or melting point of the III-V or II-VI compound based decomposition layer, and a temperature increase decomposes the III-V or II-VI compound based decomposition layer. A III-V or II-VI compound based device structure is grown on or above the III-V or II-VI compound based decomposition stop layer. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/567162 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/0262 (20130101) H01L 21/02334 (20130101) Original (OR) Class H01L 21/02381 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266835 | Perry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Christopher Perry (Manchester, New Hampshire); Stewart M. Coulter (Bedford, New Hampshire); Thomas A. Doyon (Manchester, New Hampshire) |
| ABSTRACT | A system for powering a device is disclosed. The system includes at least one internal battery located in a device, at least one external battery connected to the device, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the device. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/385009 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/382 (20190101) Electric Digital Data Processing G06F 1/263 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/482 (20130101) H01M 10/4207 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/38 (20130101) Original (OR) Class H02J 7/0013 (20130101) H02J 7/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240266939 | Raju |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ravisekhar Nadimpalli Raju (Clifton Park, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravisekhar Nadimpalli Raju (Clifton Park, New York) |
| ABSTRACT | A modular power conversion system is provided which includes a plurality of modules (building blocks) comprised of transformers and power conversion bridges. The modules are connected in series on either the input or output side and in parallel on the other side. A substantial number of the modules are operated in a fixed input-to-output voltage ratio, with the remaining module(s) operated in a variable input-to-output ratio. The fixed ratio modules are either placed in an active mode or in a bypassed mode. A controller sets the proportion of active and bypassed modules and controls the variable ratio modules, thus allowing an adjustable input-to-output ratio for the overall converter system. Prior to the bypassing of a module, the energy stored in its internal bus or link is dissipated or stored in an auxiliary circuit or moved to a neighboring module. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/107007 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/0045 (20210501) Original (OR) Class H02M 3/155 (20130101) H02M 7/217 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267407 | Parvania et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masood Parvania (Salt Lake City, Utah); Jairo Giraldo (Salt Lake City, Utah); Alejandro Palomino (Salt Lake City, Utah) |
| ABSTRACT | A security system for enhancing security of a device utilizing a communication channel includes one or more processors and a storage including instructions stored thereon. When the instructions are executed by the one or more processors, the instructions cause the security system to receive, by a plurality of Internet of Thing (IoT) devices, data from a communication source through a first communication channel, replicate, by the plurality of IoT devices, the received data, randomly activate one of non-empty subsets of the plurality of IoT devices, select a majority vote input based on the replicated data from the randomly activated subset of the plurality of IoT devices; and transmit the majority vote input to a communication destination through a second communication channel, which is different from the first communication channel. |
| FILED | Thursday, January 19, 2023 |
| APPL NO | 18/156985 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/27 (20190101) Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 30/10 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1466 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267601 | LEMIEUX et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia State University Research Foundation, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony LEMIEUX (Decatur, Georgia); Krishanu SARKER (Marietta, Georgia) |
| ABSTRACT | A content summarizing program processes audio and/or visual content of a media item to determine a plurality of segments of the content; and determines a respective ranking for each of the plurality of segments. The respective ranking indicates how representative of the content as a whole the segment is. Based on the plurality of respective rankings and summary time criteria, the content summarizing program selects summary segments from the plurality of segments; and, based on the summary segments, generates a segment transition. The segment transition corresponds to a pair of adjacent summary segments and comprises characteristics of both first and second summary segments of the pair of adjacent summary segments. The content summarizing program stitches together the summary segments using the segment transition to generate a content summary. The summary segments are stitched together with the segment transition disposed between the first summary segment and the second summary segment. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/569040 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 21/4532 (20130101) H04N 21/4666 (20130101) H04N 21/8456 (20130101) H04N 21/8549 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267794 | Shakkottai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivas G. Shakkottai (Cypress, Texas); Woo-Hyun Ko (College Station, Texas); Harish Kumar Dureppagari (Blacksburg, Virginia); Ujwal Dinesha (College Station, Texas); Venkata Siva Santosh Ganji (Bryan, Texas); Dinesh Bharadia (San Diego, California); Raini Y. Wu (San Diego, California); Ushasi Ghosh (San Diego, California) |
| ABSTRACT | In some examples, a system includes a communication network having a cloud portion and an edge portion. The communication network comprises a cloud controller, a radio access network (RAN), and an edge computing device. The edge computing device is co-located with at least a portion of the RAN. The edge computing device is configured to, within one transmission time interval (TTI) of the RAN, obtain network state information of the communication network, determine control actions for modifying operational settings of the RAN, and transmit the control actions to the RAN. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/437149 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) Wireless Communication Networks H04W 28/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240268030 | Petelik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Petelik (Alexandria, Virginia); Steven Bode (Alexandria, Virginia); Matthew Anderson (Hanover, Maryland) |
| ABSTRACT | An apparatus for interfacing with an RF/microwave subsystem is provided. The apparatus includes a printed circuit board that includes: a controller, and a connector constructed to provide control signals and power signals to a subsystem in accordance with instructions from the controller, and a mechanical interface constructed to provide a mechanical connection between the subsystem and the printed circuit board. |
| FILED | Tuesday, October 24, 2023 |
| APPL NO | 18/383470 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/716 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/181 (20130101) Original (OR) Class H05K 2201/10189 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240261428 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Sourabh Shukla (Cleveland, Ohio) |
| ABSTRACT | A pepino mosaic virus (PepMV) carrier comprising a PepMV particle that has been modified to carry an imaging agent or anticancer agent is described. The PepMV carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the PepMV carrier can be imaged using an imaging agent, or treated using an anticancer agent. |
| FILED | Tuesday, February 13, 2024 |
| APPL NO | 18/440126 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/6901 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240261774 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Sangwoo LEE (Cohoes, New York); Chulsung BAE (Cohoes, New York); Musashi J. BRIEM (Troy, New York); Sungmin PARK (Troy, New York) |
| ABSTRACT | The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594586 |
| CURRENT CPC | Separation B01D 61/44 (20130101) B01D 71/06 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/07 (20170101) Original (OR) Class B01J 41/14 (20130101) B01J 47/12 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/469 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/32 (20130101) C08F 2810/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2287 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262844 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael T. Taylor (Laramie, Wyoming); Caleb R. Hoopes (Laramie, Wyoming); Akash M. Sarkar (Laramie, Wyoming); Nicholas J. Kuehl (Laramie, Wyoming); Nicole L. Collins (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to pyridinium salts, compositions thereof, and to methods of use. In an embodiment, a pyridinium salt described herein includes a group that is transferred to a tryptophan residue or moiety of a tryptophan-containing molecule. In another embodiment, a method for modifying a tryptophan residue is provided. The method includes forming a mixture comprising a pyridinium salt and a molecule containing a tryptophan moiety, and exposing the mixture to light to chemically modify the tryptophan moiety of the molecule. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099760 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/89 (20130101) C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262845 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming); Novartis Institutes for BioMedical Research, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael T. Taylor (Laramie, Wyoming); Caleb R. Hoopes (Laramie, Wyoming); Akash M. Sarkar (Laramie, Wyoming); Nicholas J. Kuehl (Laramie, Wyoming); Nicole L. Collins (Laramie, Wyoming); Francisco J. Garcia (Cambridge, Massachusetts); David T. Barkan (Cambridge, Massachusetts); Glenna E. Meister (Cambridge, Massachusetts); Taylor R. Bramhall (Cambridge, Massachusetts); Chien-Hsiang Hsu (Cambridge, Massachusetts); Michael D. Jones (Cambridge, Massachusetts); Markus Schirle (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments of the present disclosure generally relate to pyridinium salts, compositions thereof, and to methods of use. In an embodiment, a pyridinium salt described herein includes a group that is transferred to a tryptophan residue or moiety of a tryptophan-containing molecule. In another embodiment, a method for modifying a tryptophan residue is provided. The method includes forming a mixture comprising a pyridinium salt and a molecule containing a tryptophan moiety, and exposing the mixture to light to chemically modify the tryptophan moiety of the molecule. |
| FILED | Friday, January 20, 2023 |
| APPL NO | 18/099765 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/89 (20130101) C07D 401/12 (20130101) C07D 495/04 (20130101) Original (OR) Class Peptides C07K 1/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240262957 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNIVERSITY OF SOUTHERN MISSISSIPPI (Hattiesburg, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tse Nga Ng (San Diego, California); Lulu Yao (San Diego, California); Jason Azoulay (Hattiesburg, Mississippi) |
| ABSTRACT | Embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. The conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. The conjugated backbone may comprise a connection of π-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalization—thereby stabilizing charge for the polymer. The carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/608450 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 2261/44 (20130101) C08G 2261/124 (20130101) C08G 2261/514 (20130101) C08G 2261/3223 (20130101) C08G 2261/3246 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 2201/001 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/121 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) H01G 11/48 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263074 | Kavazanjian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Kavazanjian (Tempe, Arizona); Nasser Hamdan (Scottsdale, Arizona); Hamed Khodadadi Tirkolaei (Tempe, Arizona); Abdullah Almajed (Tempe, Arizona) |
| ABSTRACT | The present disclosure provides a method of biocementation comprising contacting a granular, cohesionless soil with a solution, wherein the solution comprises urea, urease, a source of calcium ions, and a source of non-urease proteins, wherein the urea, urease, source of calcium ions, and source of non-urease proteins are provided in effective amounts suitable to cause crystallization of calcium carbonate. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/620705 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/14 (20130101) C04B 28/003 (20130101) C04B 2103/0001 (20130101) C04B 2111/00732 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 17/44 (20130101) Original (OR) Class Enzymes C12Y 305/01005 (20130101) Foundations; Excavations; Embankments; Underground or Underwater Structures E02D 3/12 (20130101) E02D 2300/0025 (20130101) E02D 2300/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263167 | BAKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); David YOUNGER (Seattle, Washington); Eric KLAVINS (Seattle, Washington) |
| ABSTRACT | The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks. |
| FILED | Wednesday, October 11, 2023 |
| APPL NO | 18/484871 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263186 | GELVIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanton B. GELVIN (West Lafayette, Indiana); Lan-Ying LEE (West Lafayette, Indiana) |
| ABSTRACT | Agrobacterium strains with mutations in the VirD2 gene and protein and expression constructs and genome-editing systems for leveraging the same. Methods are also provided for Agrobacterium-mediated incorporation of exogenous expressible nucleic acids into a host plant material using the Agrobacterium strains, expression constructs, and/or genome-editing systems. |
| FILED | Wednesday, April 10, 2024 |
| APPL NO | 18/632189 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/743 (20130101) C12N 15/8205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263187 | Dixon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Dixon (Sulphur, Oklahoma); Fang Chen (Denton, Texas); Chunliu Zhuo (Denton, Texas) |
| ABSTRACT | The disclosure provides recombinant LAC polynucleotides encoding a laccase (LAC) polypeptide capable of polymerizing caffeyl alcohol, vectors and cells including the recombinant LAC polynucleotide. The disclosure also provides transgenic plants including cells having the recombinant LAC polynucleotide of the present disclosure and methods of increasing production of C-lignin in a plant. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594315 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263333 | PHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | ELECTRASTEEL, INC. (Boulder, Colorado) |
| INVENTOR(S) | Ai Quoc PHAM (Boulder, Colorado); Sandeep NIJHAWAN (Boulder, Colorado); Adolfredo ALVAREZ (Boulder, Colorado); Colleen WALLACE (Boulder, Colorado); Steven FATUR (Boulder, Colorado) |
| ABSTRACT | Methods and systems for producing iron from an iron-containing ore are disclosed. For example, a method for producing iron comprises: providing an iron-containing ore to a dissolution subsystem comprising a first electrochemical cell and a dissolution tank; dissolving the iron-containing ore to form an acidic iron-salt solution; reducing Fe3+ ions to form Fe2+ ions and electrochemically generating protons in the first electrochemical cell; circulating solution between the dissolution tank and the first electrochemical cell; transferring formed Fe2+ ions from the dissolution subsystem to an iron-plating subsystem having a second electrochemical cell; second electrochemically reducing a first portion of the transferred formed Fe2+ ions to Fe metal at a second cathode of the second electrochemical cell; and removing the Fe metal. The methods and systems optionally include removing one or more impurities found in the feedstock. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 18/550195 |
| CURRENT CPC | Manufacture of Iron or Steel C21B 13/0073 (20130101) Processing of Pig-iron, e.g Refining, Manufacture of Wrought-iron or Steel; Treatment in Molten State of Ferrous Alloys C21C 5/5241 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/06 (20130101) C22B 5/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 15/081 (20210101) C25B 15/087 (20210101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/06 (20130101) Original (OR) Class C25C 7/04 (20130101) C25C 7/08 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264176 | Larsen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Creighton University (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter A. Larsen (Minneapolis, Minnesota); Tiffany M. Wolf (Minneapolis, Minnesota); Marc D. Schwabenlander (Minneapolis, Minnesota); Jason C. Bartz (Omaha, Nebraska); Qi Yuan (Omaha, Nebraska) |
| ABSTRACT | This document provides methods and materials for detecting misfolded poly peptides. For example, devices (e.g., feeding devices) designed to collect samples from one or more mammals (e.g., one or more cervids) are provided. In some cases, methods and materials that can be used to detect one or more prion diseases (e.g., chronic wasting disease (CWD)) in a population of mammals (e.g., a herd of cervids) based, at least in part, on the presence or absence of misfolded polypeptides in a sample from one or more mammals that was obtained from a feeding device are provided. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/567172 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/4077 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2001/4094 (20130101) G01N 2800/2828 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264246 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saransh Sharma (Pasadena, California); Azita Emami (Pasadena, California) |
| ABSTRACT | An on-chip electrical coil includes a semiconductor substrate; a plurality of metal layers disposed on the semiconductor substrate; a plurality of insulator layers disposed on the semiconductor substrate, each insulator layer disposed between a pair of neighboring metal layers to form an alternating arrangement of metal layers and insulator layers; a plurality of metal vias defined in the insulator layers, each metal via electrically connecting a respective pair of neighboring metal layers; and a planar spiral formed by the metal layers and the metal vias, the planar spiral including a plurality of interconnected loops, each loop including two metal wires disposed in respective metal layers, an intra-loop column that electrically connects the two metal wires of a respective loop, and an inter-loop column that electrically connects one of the metal wires of the respective loop to one of the metal wires in a subsequent loop. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/430870 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264247 | Sharma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saransh Sharma (Pasadena, California); Hayward Melton (Hinsdale, Illinois); Azita Emami (Pasadena, California) |
| ABSTRACT | A three-dimensional on-chip magnetic sensor includes first, second, and third coils. The first and second coils include respective planar spirals formed by metal layers and metal vias. Each planar spiral of the first coil includes first interconnected loops wound about a first axis, where neighboring first planar spirals are electrically connected to each other. Each planar spiral of the second coil includes second interconnected loops wound about a second axis, where neighboring second planar spirals are electrically connected to each other. The third coil has a planar spiral includes third interconnected loops that are wound about a third axis. Each electrically conductive coil is configured to produce a respective electromagnetic force (EMF) induced by an oscillating magnetic field, the respective EMF driving a respective alternating current (AC) through the respective readout circuit. Each readout circuit is configured to detect a respective peak voltage magnitude of the respective AC. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/430936 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/062 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0206 (20130101) G01R 33/0286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264251 | Bowers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford Russell Bowers (Gainesville, Florida); Maria-Jose Ferrer (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for systems and methods of making, processing, and purifying hyperpolarized fluid samples and fractions thereof as well as detecting and using the hyperpolarized fluid samples. The present disclosure provides for methods and systems of making hyperpolarized fluid sample (e.g., hyperpolarized target molecules), which can be analyzed using a nuclear magnetic resonance (NMR) detection device. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/567084 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/282 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264670 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ekansh Gupta (Atlanta, Georgia); Raghupathy Sivakumar (Atlanta, Georgia); Cheng-Yeh Chen (Atlanta, Georgia) |
| ABSTRACT | An exemplary system and method are disclosed that can detect unobserved and unobservable signals in a subject, or system, using an auxiliary, secondary signal measured from the subject while the unobserved and unobservable signals are known to be present. In particular, the exemplary system and method can used to measure observed signals, e.g., in a nonlinear time-variant system (NLTV system) such as the brain, to measure the unobserved or unobservable signal of interest via response coupling that employs a test instrument configured to facilitate interactions between the primary and the auxiliary signal. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432937 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 13/08 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240265173 | Nyarko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kofi Nyarko (Baltimore, Maryland); Benjamin Hall (Baltimore, Maryland) |
| ABSTRACT | A novel implementation of particle swarm optimization termed Recursive Hierarchical Particle Swarm Optimization (RHPSO) is presented. An improved method for optimizing a complex solution space for any given mathematical function, where the mathematical function may be 1) finding optimal parameters such as topology, security, and routing in distributed/networked systems; 2) finding optimal frequency and channel assignments for telecommunication networks; and 3) code-breaking, searching a large solution space of ciphers for the one correct decryption. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535700 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/25 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267213 | Guan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NTT Research, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | NTT Research, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Jiaxin Guan (New York, New York); Daniel Wichs (Boston, Massachusetts); Mark Zhandry (New York, New York) |
| ABSTRACT | The present disclosure relates to a computerized method and system for message encryption in a multi-user setting. The method involves receiving a message of arbitrary length for each user, storing the message in a computerized data store, and executing a setup to generate a master secret and public keys. A random variable is generated, and a function is defined based on this variable. A second secret is derived using a functional encryption scheme, resulting in a derived secret. The message is encrypted by generating a first random string, a second partially random string, and a ciphertext. The system also includes a method for decrypting the encrypted message, processing the derived secret and ciphertext to derive a string, and deriving a plaintext message from this string. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/437215 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) H04L 9/0869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267794 | Shakkottai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivas G. Shakkottai (Cypress, Texas); Woo-Hyun Ko (College Station, Texas); Harish Kumar Dureppagari (Blacksburg, Virginia); Ujwal Dinesha (College Station, Texas); Venkata Siva Santosh Ganji (Bryan, Texas); Dinesh Bharadia (San Diego, California); Raini Y. Wu (San Diego, California); Ushasi Ghosh (San Diego, California) |
| ABSTRACT | In some examples, a system includes a communication network having a cloud portion and an edge portion. The communication network comprises a cloud controller, a radio access network (RAN), and an edge computing device. The edge computing device is co-located with at least a portion of the RAN. The edge computing device is configured to, within one transmission time interval (TTI) of the RAN, obtain network state information of the communication network, determine control actions for modifying operational settings of the RAN, and transmit the control actions to the RAN. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/437149 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) Wireless Communication Networks H04W 28/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240261441 | ASSOULINE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NANOMEDTRIX, LLC (Coralville, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joe G. ASSOULINE (Coralville, Iowa); Sean K. SWEENEY (Coralville, Iowa) |
| ABSTRACT | Mesoporous silica nanoparticles (MSNs) that may be useful as ultrasound contrast agents for detecting and treating bladder cancer are described herein. The MSNs include a lanthanide, a fluorophore, and an agent detectable by ultrasound. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/620709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/16 (20130101) A61K 49/0089 (20130101) A61K 49/1824 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263361 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Mengmeng ZHANG (Dallas, Texas); Ray BAUGHMAN (Dallas, Texas); Shaoli FANG (Richardson, Texas); Jiyoung OH (Fort Worth, Texas); Zhong WANG (Dallas, Texas); Fatma GÖKTEPE (Istanbul, Turkey); Özer GÖKTEPE (Istanbul, Turkey) |
| ABSTRACT | Methods for fabricating coiled polymer fibers and yarns (high-spring-index coiled fibers and yarns). Methods include inserting twist separately into individual fibers or yarns, plying the fibers or yarns by inserting plying twist, setting the ply structure without permanently binding together the fibers or yarns of different plies so that the ply structure is substantially stable against untwist when torsionally untethered, and then unwrapping the plied fibers or yarns so that a high-spring-index fiber or yarn can be obtained. In some embodiments, the unwrapped fibers or yarns are further set so that these are further stabilized. The methods can eliminate the need for a mandrel, and can be quickly applied for applications where high-spring-index thermally-driven artificial muscles are presently employed, such as for presently commercialized comfort-adjusting jackets. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431022 |
| CURRENT CPC | Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 1/028 (20130101) D02G 1/0286 (20130101) D02G 3/02 (20130101) D02G 3/12 (20130101) D02G 3/38 (20130101) D02G 3/448 (20130101) Original (OR) Class Finishing or Dressing of Filaments, Yarns, Threads, Cords, Ropes or the Like D02J 13/00 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 15/41 (20210101) D03D 15/49 (20210101) D03D 15/283 (20210101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2331/02 (20130101) D10B 2331/10 (20130101) D10B 2505/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06143 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264168 | MESSMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Abreos Biosciences, Inc. (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley T. MESSMER (San Diego, California); Dina UZRI (San Diego, California); Jessie-Farah FECTEAU (San Diego, California) |
| ABSTRACT | Methods and assays for detecting natalizumab in a sample, natalizumab-peptide complexes in a sample, and point-of-care devices for detecting natalizumab in a sample are described herein. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404461 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240265173 | Nyarko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kofi Nyarko (Baltimore, Maryland); Benjamin Hall (Baltimore, Maryland) |
| ABSTRACT | A novel implementation of particle swarm optimization termed Recursive Hierarchical Particle Swarm Optimization (RHPSO) is presented. An improved method for optimizing a complex solution space for any given mathematical function, where the mathematical function may be 1) finding optimal parameters such as topology, security, and routing in distributed/networked systems; 2) finding optimal frequency and channel assignments for telecommunication networks; and 3) code-breaking, searching a large solution space of ciphers for the one correct decryption. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535700 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/25 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240261410 | PRICE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NEIL P. PRICE (EDELSTEIN, Illinois); MICHAEL A. JACKSON (MORTON, Illinois) |
| ABSTRACT | The disclosure provides stable aqueous formulations comprising an antibiotic and sodium deoxycholate (DOC), and optionally further comprising at least one carrier and/or excipient. The disclosure also provides methods for preparing such aqueous formulations, and methods for using such aqueous formulations to treat, attenuate, or prevent bacterial infection in a subject. |
| FILED | Wednesday, February 08, 2023 |
| APPL NO | 18/166114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 31/7072 (20130101) A61K 47/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263143 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Agathos Biologics (Fargo, North Dakota) |
| ASSIGNEE(S) | Agathos Biologics (Fargo, North Dakota) |
| INVENTOR(S) | James Brown (Fargo, North Dakota); Michael Chambers (Fargo, North Dakota); John Ballantyne (Fargo, North Dakota); Jagadish Loganathan (Fargo, North Dakota); Andrzej Noyszewski (Fargo, North Dakota); Amber Plambeck (Fargo, North Dakota) |
| ABSTRACT | Disclosed is the creation of new E1-complementing BHK-21 cell lines to produce recombinant adeno-associated virus (rAAV) vectors. The new cell lines stably express the E1 gene region of adenovirus or a portion thereof and produce the E1 proteins. Transient production in the E1-complementing cell lines of the AAV rep/cap proteins, helper proteins and an AAV transfer plasmid containing the desirable transgene flanked by the Inverted Terminal Repeat (ITR) sequences of AAV, results in production of rAAV particles containing the transgene. Further disclosed is scaled-up production, harvesting and purification of transgene-containing rAAV. The purified rAAV has demonstrated capability to infect a host cell line and express the protein encoded by the transgene. The disclosure provides non-human, non-embryonic cell lines for production of rAAV particles that are a platform for delivery of a desired transgene. |
| FILED | Thursday, February 01, 2024 |
| APPL NO | 18/430090 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) C12N 5/0686 (20130101) Original (OR) Class C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2510/02 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264138 | IVERSEN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WILLIAM M. IVERSEN (SIDNEY, Montana) |
| ABSTRACT | The hand carried enhanced penetrometer includes an electrical linear actuator system to advance a soil penetration rod into a test site soil during a penetrometer test. The penetrometer also includes a base plate system that uses an operator's static body weight to anchor the penetrometer to a test site surface during a penetrometer test. In operation, an operator places at least one foot on a penetrometer structural base plate and activates the linear actuator to advance a penetration rod into the test site soil. The tripod embodiment of the system includes an operator's seat that allows an operator to conduct a penetrometer test in a seated position while passively anchoring the penetrometer in place at the test site. The invention includes monopod, bipod, and tripod embodiments. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/106101 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240260875 | GURCHIEK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reed GURCHIEK (Essex Junction, Vermont); Ryan MCGINNIS (Shelburne, Vermont) |
| ABSTRACT | A system for determining dynamics of a joint of an individual includes a first muscle contraction sensor configured to measure an excitation of a first muscle adjacent to a joint; a first movement sensor configured to measure movement on a first side of the joint; a second muscle contraction sensor configured to measure an excitation of a second muscle located adjacent to the joint; and a second movement sensor configured to measure movement on a second side of the joint. A machine learning processor is trained to determine a full set of excitation values based on an excitation value from the first muscle contraction sensor and an excitation value from the second muscle contraction sensor. A processor is configured to determine a joint moment based on values from the first and second movement sensors and the set of excitation values from the machine learning processor. |
| FILED | Thursday, May 12, 2022 |
| APPL NO | 18/560644 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/224 (20130101) Original (OR) Class A61B 5/389 (20210101) A61B 5/1107 (20130101) A61B 5/4528 (20130101) A61B 5/6802 (20130101) A61B 5/7264 (20130101) A61B 2562/06 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264062 | Rohler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Plexar Associates, Inc. (Shaker Heights, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David P. Rohler (Shaker Heights, Ohio); Steven H. Izen (Shaker Heights, Ohio) |
| ABSTRACT | A tomography duct for wind tunnels includes a plurality of light sources and sensors displaced around a support structure. The light sources are cycled and sensor measurements are made from sensors opposite the light sources. Tomographic algorithms are used to determine an extinction map from the sensor measurements. The extinction map provides details about particles in a cross-section of the air flow through the tomography duct. Imaging is accomplished via star-shaped source and detector arrays. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/636088 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 15/075 (20240101) G01N 33/0009 (20130101) G01N 33/0031 (20130101) G01N 33/0036 (20130101) G01N 33/1873 (20240501) G01N 2015/0026 (20130101) G01N 2015/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264669 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICAS AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio); UNITED STATES OF AMERICAS AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| INVENTOR(S) | Michael E. Miller (XENIA, Ohio); BRETT J. BORGHETTI (BEAVERCREEK, Ohio); KELLIE D. KENNEDY (POQUOSON, Virginia); CHAD L. STEPHENS (POQUOSON, Virginia); ALAN T. POPE (POQUOSON, Virginia) |
| ABSTRACT | A brain-computer interface system includes a video processor for producing a display signal, a temporal controller for producing a plurality of repetitive visual stimulus (RVS) signals with different respective temporal aspects, a display device that receives the display signal and displays a corresponding image on a plurality of different display regions and receives the RVS signals and displays corresponding RVS in respective ones of the display regions, an electroencephalographic (EEG) sensor for sensing a visually-evoked cortical potential (VECP) signal in a user with eyes fixated on a viewed one of the display regions, and a VECP processor for processing the VECP signal to identify the respective temporal aspect of the respective RVS of the viewed display region to estimate the eye fixation location. The RVS are generated independently of the display update/refresh rate and at sufficiently high frequencies to avoid flicker perceptible to the user. |
| FILED | Thursday, February 02, 2023 |
| APPL NO | 18/104913 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/013 (20130101) G06F 3/015 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 5/005 (20130101) G09G 2340/0435 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240265125 | Katwala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gopi Katwala (Germantown, Maryland); David Frank Ferraiolo (Ashburn, Virginia) |
| ABSTRACT | An embedded next generation access control system imposes fine-grained access control on data in a resource database and includes a resource database, NGAC database, administrator, and mediator. The resource database includes controlled resource data and a mediator. The NGAC database includes an adjudicator and access control policy data. The administrator communicates access control policy input to the NGAC database upon which access control policy data is made in the NGAC database. The controlled resource data is access controlled by access control policy data via calls of an adjudicator API, which implements Next Generation Access Control standard by NIST, by the resource database to obtain access decisions. The adjudicator determines which controlled resource data are accessed by a user and provides an access control list for each user and user attribute. The adjudicator also provides a prohibited access control list for a user and user attributes in the access control policy data if there are any. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435671 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240265581 | Vemury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland); Yevgeniy Sirotin (Severna Park,, Maryland); John Howard (Bethesda, Maryland); Jerry Tipton (Severn, Maryland) |
| ABSTRACT | Systems and methods for measuring skin tone. A camera and computer may measure skin tone health of a face dataset and color quality of a single face image. The computer and camera may measure skin tone across wide sample of volunteers, express skin tone in CIELCH coordinates; and identify the range of observed lightness, chromaticity, and hue values in the population to determine a sample set. The computer and camera may be configured to match the image to a coordinate system of lightness, chromaticity, and hue in the sample set. If a match is not possible, the computer may be configured to select a coordinate closest to the measured lightness, chromaticity, and hue. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639514 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/80 (20170101) G06T 7/90 (20170101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/30201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240261334 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children's Hospital DBA Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623246 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240260744 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William A. Tartal (Baltimore, Maryland); Joel Dewnandan (Bladensburg, Maryland); Gabriel M. Yessin (Arlington, Virginia); Joram Shenhar (Fairfax, Virginia) |
| ABSTRACT | A postal service cart includes a base member and a support member extending from the base member. The support member includes a first end connected with the base member and a second end. A system support surface is connected to the support member at the second end. The system support surface includes a first support zone configured to support a first portion of a customer interface system and a second support zone including a component placement location restrictor configured to support a second portion of the customer interface system. The component placement location restrictor confines placement of the second portion of the customer interface system to a section of the second support zone adjacent the forward edge. |
| FILED | Tuesday, February 07, 2023 |
| APPL NO | 18/165616 |
| CURRENT CPC | Tables; Desks; Office Furniture; Cabinets; Drawers; General Details of Furniture A47B 21/04 (20130101) Original (OR) Class A47B 31/00 (20130101) A47B 2200/0023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240262535 | Rosner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | True Anomaly, Inc. (Centennial, Colorado) |
| ASSIGNEE(S) | True Anomaly, Inc. (Centennial, Colorado) |
| INVENTOR(S) | Ariel Rosner (Denver, Colorado); Kyle Nicholas Zakrzewski (Broomfield, Colorado); Sean Deniz Ozdemir (Lakewood, Colorado) |
| ABSTRACT | A spacecraft bus system described herein includes a propulsion assembly, a top plate assembly, and a bottom plate assembly. Each one of the propulsion assembly, the top plate assembly, and the bottom plate assembly is configured to be separately assembled and tested for spaceworthiness. Also described herein is a propulsion assembly for use with a spacecraft. The propulsion assembly includes a propellant tank containing propellant therein, at least one thruster, and a frame configured for supporting the propellant tank and the at least one thruster thereon. The propulsion assembly, as an individual module, is configured to be assembled and subjected to testing related to spaceworthiness. Additionally, the frame may be further configured for attachment to other components of the spacecraft, after being assembled and subjected to testing, without modification to the propulsion assembly or the other components of the spacecraft. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216571 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/36 (20130101) B64G 1/223 (20230801) Original (OR) Class B64G 1/443 (20130101) B64G 1/4022 (20230801) B64G 4/00 (20130101) B64G 2004/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263567 | Glahn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jorn A. Glahn (Manchester, Connecticut); Gregory M. Dooley (Glastonbury, Connecticut); Collin P. Fitzgerald (S. Glastonbury, Connecticut) |
| ABSTRACT | An assembly is provided for a turbine engine. This assembly includes a rotating structure rotatable about an axis, a stationary structure and a bearing. The stationary structure forms a bearing compartment, a buffer cavity, a low pressure cavity and a high pressure cavity with the rotating structure. The buffer cavity surrounds the bearing compartment. The low pressure cavity surrounds the buffer cavity. The high pressure cavity surrounds the low pressure cavity. The bearing is within the bearing compartment. The bearing rotatably couples the rotating structure to the stationary structure. |
| FILED | Friday, February 03, 2023 |
| APPL NO | 18/105623 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 25/16 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/54 (20130101) F05D 2240/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240263599 | SIDHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PHASE FOUR, INC. (Hawthorne, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SIDHU (RANCHO PALOS VERDES, California); Mohammed Umair SIDDIQUI (INGLEWOOD, California); Derek THOMPSON (LOS ANGELES, California); Jason Jackson WALLACE (PASADENA, California) |
| ABSTRACT | Systems and methods for a multimode propulsion system (MMPS) are presented. The MMPS includes a chemical thruster, an electric thruster, and a shared propellant tank. The MMPS further includes a propellant decomposition chamber that transforms, via a catalytic and/or electrolytic process, the propellant from the tank into vapor form for use as gas propellant by the electric thruster. The electric thruster can be configured for targeted ionization of one or more constituent species present in the vapor form of the propellant. Flow activation/control from the tank to the chemical and electric thrusters is provided by a fluidic feed system. The branches include a check valve and a pressure regulator in series connection. A normally closed squib valve prevents propellant flows/leaks from the tank to either the chemical or the electric thrusters when the MMPS is not in operation. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/497442 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/44 (20130101) Original (OR) Class F02K 9/58 (20130101) F02K 9/605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240264094 | Howard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher T. Howard (Atlanta, Georgia); Kenneth Wayne Allen (Atlanta, Georgia); William Daniel Hunt (Atlanta, Georgia); David R. Reid (Atlanta, Georgia) |
| ABSTRACT | The exemplary system and method for the characterization procedures for complex permittivity of a dielectric material at radio frequencies, including microwave and millimeter-wave wavelengths. The exemplary system and method employ a highly resonant periodic array affixed or placed in proximity thereto to provide a frequency response that varies based on the constituent electromagnetic properties of a sample of dielectric material. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431425 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 27/267 (20130101) G01R 27/2664 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240267131 | Guha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Saikat Guha (Tucson, Arizona); Ali Cox (Tucson, Arizona); Quntao Zhuang (Tucson, Arizona); Christos Gagatsos (Tucson, Arizona); Boulat Bash (Tucson, Arizona) |
| ABSTRACT | Processing codewords comprises: receiving encoded signals associated with reference signals related by quantum entanglement, where the encoded signals have been encoded with respective phases corresponding to symbols of a particular codeword; performing a first nonlinear optical process with inputs comprising a first signal derived from the encoded signals and a first signal derived from the reference signals; performing a second nonlinear optical process with inputs comprising a second signal derived from the encoded signals and a signal derived from a first output of the first nonlinear optical process; performing a first linear optical process with inputs comprising a signal derived from a second output of the first nonlinear optical process and a signal derived from a first output of the second nonlinear optical process; and processing information that includes signals derived from one or more outputs of the first linear optical process to generate an estimate of the particular codeword. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/289884 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Original (OR) Class H04B 10/615 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 08, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240808.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page