FedInvent™ Patent Applications
Application Details for Thursday, August 22, 2024
This page was updated on Wednesday, September 04, 2024 at 02:56 AM GMT
Department of Health and Human Services (HHS)
| US 20240277243 | CASTRO-GONZALEZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); UNIVERSIDAD POLITECNICA DE MADRID (Madrid, Spain) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); UNIVERSIDAD POLITECNICA DE MADRID (Madrid, Spain) |
| INVENTOR(S) | Carlos CASTRO-GONZALEZ (Cambridge, Massachusetts); Ian BUTTERWORTH (Somerville, Massachusetts); Aurelien BOURQUARD (Cambridge, Massachusetts); Alvaro Sanchez FERRO (Madrid, Spain); Jason TUCKER-SCHWARTZ (Melrose, Massachusetts); Alberto PABLO TRINIDAD (Madrid, Spain); MARIA J. LEDESMA CARBAYO (Madrid, Spain); Tom Vettenburg (Dundee, United Kingdom) |
| ABSTRACT | A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images. |
| FILED | Thursday, April 11, 2024 |
| APPL NO | 18/633176 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0261 (20130101) Original (OR) Class A61B 5/489 (20130101) A61B 5/1455 (20130101) A61B 5/6826 (20130101) A61B 5/7203 (20130101) A61B 5/7267 (20130101) A61B 5/14546 (20130101) A61B 2576/02 (20130101) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 2207/10016 (20130101) G06T 2207/10152 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 40/10 (20220101) G06V 40/14 (20220101) G06V 40/15 (20220101) Technologies for Adaptation to Climate Change Y02A 90/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277244 | FERGUSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sahba Aghajani PEDRAM (Oakland, California); Tsu-Chin TSAO (Oakland, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Peter Walker FERGUSON (Los Angeles, California); Sahba Aghajani PEDRAM (Los Angeles, California); Matthew GERBER (Los Angeles, California); Jacob Rosen (Los Angeles, California); Jean-Pierre HUBSCHMAN (Los Angeles, California); Tsu-Chin TSAO (Los Angeles, California); Ismael CHEHAIBOU (Los Angeles, California); Anibal FRANCONE (Los Angeles, California) |
| ABSTRACT | According to certain general aspects, the present embodiments relate generally to identifying tissue, fluid and/or anatomical structures at the tip of a surgical tool. The determination of the tissue, fluid and/or anatomical structures that the tool is touching allows the inference of a position inside of a person undergoing surgery. For example, a surgeon may attempt to use a tool to interact with a lens portion of a person's eye during cataract surgery, but the identification of tissue provided by embodiments will indicate that the tool is at a position too deep inside of the eye. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/569976 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0537 (20130101) Original (OR) Class A61B 5/0538 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/00736 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277248 | Shih et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
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| INVENTOR(S) | Yen-Yu Shih (Cary, North Carolina); Martin John Mackinnon (Raleigh, North Carolina); Yuncong Ma (Chapel Hill, North Carolina); Wei-Tang Chang (Chapel Hill, North Carolina) |
| ABSTRACT | This specification describes systems and methods for using Zero Echo Time (ZTE) magnetic resonance imaging (MRI) sequences for applications to functional MRI (fMRI). In some examples, a system for functional magnetic resonance imaging includes a magnetic resonance imaging (MRI) scanner and a control console implemented on at least one processor. The control console is configured for executing, using the MRI scanner, a zero echo time (ZTE) pulse sequence; acquiring, using the MRI scanner, magnetic resonance data in response to the ZTE pulse sequence; and constructing at least one MRI image using the magnetic resonance data and measuring tissue oxygenation (PtO2)-related T1 changes as a proxy of neural activity changes of a subject using the at least one MRI image. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/635821 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/48 (20130101) G01R 33/4824 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277252 | Dravid et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Vinayak P. Dravid (Evanston, Illinois); Gajendra S. Shekhawat (Evanston, Illinois) |
| ABSTRACT | Nanomechanical sensors comprising an antibody-functionalized microcantilever and methods of using the same are described herein. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/572345 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) Original (OR) Class A61B 5/097 (20130101) A61B 2010/0087 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/04 (20130101) B81B 2201/0214 (20130101) B81B 2203/0118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54373 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277407 | Sebek et al. |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); phenoMapper, LLC (San Jose, California) |
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| INVENTOR(S) | Jan Sebek (Manhattan, Kansas); Punit Prakash (Manhattan, Kansas); Henky Wibowo (San Jose, California) |
| ABSTRACT | Catheter-based applicators incorporating a microwave ablation antenna are provided. The applicator can be flexible and suitable for delivering ablation to target tissues via endoscopic approaches as well as intracavitary/intraluminal approaches. The applicators are configured to create large volume thermal ablation zones with minimal radiation losses along the applicator axis traveling proximal to the ablation zone. This effect is accomplished by employing a backward-facing choke element and/or a multi-slotted antenna having a plurality of spaced-apart conducting elements encircling the antenna. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 18/044012 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 34/20 (20160201) A61B 90/37 (20160201) A61B 90/39 (20160201) A61B 2018/00023 (20130101) A61B 2018/00083 (20130101) A61B 2018/00178 (20130101) A61B 2018/00577 (20130101) A61B 2018/00702 (20130101) A61B 2018/00791 (20130101) A61B 2018/00886 (20130101) A61B 2018/1823 (20130101) A61B 2018/1838 (20130101) A61B 2018/1846 (20130101) A61B 2018/1853 (20130101) A61B 2018/1861 (20130101) A61B 2090/376 (20160201) A61B 2090/3966 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277420 | KRISHNASWAMY et al. |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
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| INVENTOR(S) | Venkataramanan KRISHNASWAMY (Lebanon, New Hampshire); Richard J. BARTH, JR. (Hanover, New Hampshire); Keith D. PAULSEN (Hanover, New Hampshire) |
| ABSTRACT | A patient-specific device for guiding resection of a tumor located in local tissue of a patient includes a locator form and a surgical guidance cue. The locator form has a locator-form surface matching a surface of the local tissue of the patient near the tumor's location when the local tissue is imaged in a preoperative position, such that the locator form, when fit to the surface of the local tissue, restores the local tissue to the preoperative position. The surgical guidance cue is integrally formed with the locator form and based on images including only preoperative images of the local tissue in the preoperative position, to indicate a spatial property of the tumor in the preoperative position. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/596183 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 34/20 (20160201) Original (OR) Class A61B 34/25 (20160201) A61B 90/361 (20160201) A61B 2017/008 (20130101) A61B 2017/3405 (20130101) A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2034/2065 (20160201) A61B 2090/365 (20160201) A61B 2090/378 (20160201) A61B 2090/395 (20160201) A61B 2090/3908 (20160201) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 2207/30068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277574 | Wood et al. |
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| FUNDED BY |
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| APPLICANT(S) | DEKA products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan P. Wood (Bedford, New Hampshire); Michael J. Haynes (Manchester, New Hampshire); Hans Erik Johnson (Salem, New Hampshire); Thaddeus Joseph Hughes (Manchester, New Hampshire); Robert Houston Lawler, JR. (Manchester, New Hampshire) |
| ABSTRACT | A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position. |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/634275 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/10 (20130101) A61J 1/2013 (20150501) Original (OR) Class A61J 1/2037 (20150501) A61J 1/2079 (20150501) A61J 2205/60 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 35/7137 (20220101) Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 3/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277616 | Whitehead et al. |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Kathryn Ann Whitehead (Pittsburgh, Pennsylvania); Jilian Melamed (Pittsburgh, Pennsylvania) |
| ABSTRACT | Lipid-containing particles and formulations containing the lipid-containing particles are provided. Methods of delivery of therapeutic agents to the pancreas using the lipid-containing particles are provided. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 31/711 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277631 | Barnett et al. |
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| APPLICANT(S) | West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia); Temple University-Of the Commonwealth System of Higher Education (Philadelpha, Pennsylvania); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | John B. Barnett (Morgantown, West Virginia); Werner Geldenhuys (Morgantown, West Virginia); Jonathan Soboloff (Phildelphia, Pennsylvania); Harry Colbert Blair (Pittsburgh, Pennsylvania); Jamie McCall (Morgantown, West Virginia) |
| ABSTRACT | A method of inhibiting the development of osteoclasts in patients having multiple myeloma comprising administering to a patient having multiple myeloma a therapeutically effective amount of N-Methyl-dichloropropionaniline (i.e. also known as ELP-004) for inhibiting the development of osteoclasts. The method includes wherein said N-Methyl-dichloropropionaniline is administered to said patient in a pharmaceutically acceptable vehicle. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/438308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/136 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277671 | Johnson |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
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| INVENTOR(S) | Bankole A. Johnson (Charlottesville, Virginia) |
| ABSTRACT | Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes. |
| FILED | Friday, March 29, 2024 |
| APPL NO | 18/622489 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) Original (OR) Class A61K 31/7048 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6888 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/172 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277672 | Boons |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
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| INVENTOR(S) | Geert-Jan Boons (Athens, Georgia) |
| ABSTRACT | Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof. |
| FILED | Wednesday, January 03, 2024 |
| APPL NO | 18/403028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4188 (20130101) Original (OR) Class A61K 47/6803 (20170801) A61K 47/6809 (20170801) A61K 47/6849 (20170801) A61K 49/0043 (20130101) A61K 49/0058 (20130101) Peptides C07K 16/00 (20130101) C07K 16/2803 (20130101) C07K 2317/41 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277678 | Prossnitz et al. |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
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| INVENTOR(S) | Eric R. Prossnitz (Albuquerque, New Mexico); Geetanjali Sharma (Albuquerque, New Mexico); Matthias Barton (Zurich, Switzerland); Matthias R. Meyer (Stallikon, Switzerland) |
| ABSTRACT | The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS). |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586669 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) A61K 31/435 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 31/437 (20130101) A61K 31/4355 (20130101) A61K 31/7088 (20130101) A61K 38/28 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277684 | MAJETSCHAK et al. |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
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| INVENTOR(S) | Matthias MAJETSCHAK (Tampa, Florida); Anthony DESANTIS (Tampa, Florida); Xianlong GAO (Tampa, Florida) |
| ABSTRACT | CCR2 is involved in the regulation of normal cardiovascular function and during the cardiovascular stress response to hemorrhagic shock and fluid resuscitation. Disclosed herein are methods of using CCR2 inhibitors to reduce fluid requirements and to prevent death from hemodynamic decompensation during resuscitation. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/638133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277696 | TOOMBS |
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| APPLICANT(S) | Proniras Corporation (Seattle, Washington) |
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| INVENTOR(S) | Christopher Francis TOOMBS (Sammamish, Washington) |
| ABSTRACT | The present disclosure relates to methods of treating a disease (e.g., a seizure) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of tezampanel, a pharmaceutically acceptable salt thereof, or a prodrug thereof, alone or in combination with a therapeutically effective amount of a benzodiazepine, a pharmaceutically acceptable salt thereof, or a prodrug thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/566735 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4725 (20130101) Original (OR) Class A61K 31/5513 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277697 | TOOMBS |
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| FUNDED BY |
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| APPLICANT(S) | Proniras Corporation (Seattle, Washington) |
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| INVENTOR(S) | Christopher Francis TOOMBS (Sammamish, Washington) |
| ABSTRACT | The present disclosure relates to methods of treating or preventing a condition (e.g., a symptom associated with opiate withdrawal or opiate relapse) in a subject, comprising administering to the subject a therapeutically effective amount of tezampanel, a pharmaceutically acceptable salt thereof, or a prodrug thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/566736 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4725 (20130101) Original (OR) Class A61K 31/5513 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277730 | Singh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska); THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kamlendra Singh (Columbia, Missouri); Siddappa Byrareddy (Omaha, Nebraska); Arpan Acharya (Omaha, Nebraska) |
| ABSTRACT | The present invention relates to compounds, compositions, and methods, for treating viral infections. In particular, entry inhibitor compounds are disclosed for treatment of coronavirus infections, including SARS-COV-1 and SARS-COV-2 infections. The compounds bind to the interface of a SARS-COV-2 spike protein receptor binding domain (RBD) and a host cell ACE-2 receptor. The entry inhibitor compounds show antiviral activity, favorable kinetics, and temporally act at the entry of SARS-COV-2 infection. In embodiments, the compounds are used as medicaments for the inhibition of viral replication including SARS-COV-1 and/or SARS-COV-2 replication, for the treatment or prophylaxis of viral infections including SARS-COV-1 and SARS-COV-2 infections, and/or for the treatment or prophylaxis of an illness due to SARS-COV-1 and SARS-COV-2 infections. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/548657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/145 (20130101) A61K 31/277 (20130101) A61K 31/404 (20130101) A61K 31/428 (20130101) A61K 31/553 (20130101) Original (OR) Class A61K 31/4174 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 31/5545 (20170801) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277743 | Burke et al. |
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| APPLICANT(S) | The Board of Trustees Of The University Of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin D. Burke (Champaign, Illinois); Alexander G. Cioffi (Urbana, Illinois); Katrina A. Muraglia (Champaign, Illinois); Jennifer Hou (Champaign, Illinois); Anthony S. Grillo (Champaign, Illinois) |
| ABSTRACT | Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277751 | Moon et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James J. Moon (Ann Arbor, Michigan); Xiaoqi Sun (Ann Arbor, Michigan); Kyung Soo Park (Ann Arbor, Michigan); Xuehui Huang (Ann Arbor, Michigan) |
| ABSTRACT | This disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject. In particular, the present invention is directed to crystalline polymorphic forms (e.g. coordinate polymeric forms) of STING agonists associated (e.g. mixed) with one or more metal ions (e.g., Zn2+, Mn2+, Al3+, Fe3+, Cu2+), as well as systems and methods utilizing such compositions (e.g., in therapeutic settings). |
| FILED | Friday, October 15, 2021 |
| APPL NO | 18/031832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7084 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 47/6455 (20170801) A61K 2039/572 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277752 | RAMUNAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | John RAMUNAS (Menlo Park, California); Eduard YAKUBOV (Houston, Texas); Helen M. BLAU (Menlo Park, California); John COOKE (Houston, Texas) |
| ABSTRACT | Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/637899 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Original (OR) Class A61K 38/45 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1276 (20130101) C12N 15/52 (20130101) Enzymes C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277764 | METELITSA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng LIU (Houston, Texas); Gianpietro DOTTI (Houston, Texas); Andras HECZEY (Houston, Texas) |
| ABSTRACT | The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/449841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 31/4545 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/001171 (20180801) A61K 45/06 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/55527 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2500/02 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277778 | TRINCHIERI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giorgio TRINCHIERI (Bethesda, Maryland); Amiran Kasanovich DZUTSEV (Bethesda, Maryland); John Anthony MCCULLOCH (Bethesda, Maryland); Richard R. RODRIGUES (Frederick, Maryland); Diwakar DAVAR (Pittsburgh, Pennsylvania); Hassane Mohamed ZAROUR (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods for treating cancer by administering an immune checkpoint inhibitor and modifying an amount of one or more bacteria in an intestine of the subject. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/2818 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277810 | KANNEGANTI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thirumala-Devi KANNEGANTI (Memphis, Tennessee); Rajendra KARKI (Memphis, Tennessee) |
| ABSTRACT | Methods for inducing inflammatory cell death and treating cancer are provided, which include the targeting of a component of the ZBP1-ADAR1 PANoptosis pathway and the use of a combination of one or more interferons or one or more agents that upregulate interferon production and one or more nuclear export inhibitors. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 18/565700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 31/497 (20130101) A61K 38/21 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277819 | DANIELL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Henry DANIELL (Media, Pennsylvania); Robert P. RICCIARDI (Kennett Square, Pennsylvania) |
| ABSTRACT | Compositions and methods for reducing viral load in the oral cavity, particularly Coronavirus such as SARS-CoV-2 and Influenza viral loads are disclosed. Also disclosed are compositions and methods for reducing bacterial or fungal loads in the oral cavity. The compositions comprise a trapping molecule having binding affinity for a protein, glucan, or other molecule on the surface of a virus or microorganism. A carrier appropriate for oral administration, in the form of a chewing gum, long-acting lozenge, or tablet, is further disclosed, to enable easy administration before or after exposure to the infective agent. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/560153 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0058 (20130101) A61K 31/728 (20130101) A61K 38/48 (20130101) Original (OR) Class A61K 38/168 (20130101) A61K 47/02 (20130101) A61K 47/12 (20130101) A61K 47/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/16 (20180101) Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277822 | NUSSENBLATT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Enzo Biochem, Inc. (Farmingdale, New York) |
| ASSIGNEE(S) | Enzo Biochem, Inc. (Farmingdale, New York) |
| INVENTOR(S) | Robert NUSSENBLATT (Bethesda, Maryland); Baoying LIU (North Potomac, Maryland); Lai WEI (Rockville, Maryland); Elazar RABBANI (New York, New York); James J. DONEGAN (Amesbury, Massachusetts) |
| ABSTRACT | The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431293 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2035/122 (20130101) A61K 2039/577 (20130101) A61K 2039/55583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277823 | Vinetz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Vinetz (New Haven, Connecticut) |
| ABSTRACT | Provided are Leptospiral virulence modifying (VM) proteins, or fragments comprising the DNase domain thereof, and their use as vaccines and therapeutic agents. Also provided are pan-vaccines comprising multiple VM proteins. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 18/681192 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0225 (20130101) Original (OR) Class A61K 2039/575 (20130101) A61K 2039/55555 (20130101) A61K 2039/55572 (20130101) Peptides C07K 14/195 (20130101) C07K 16/1207 (20130101) C07K 2317/565 (20130101) C07K 2319/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277829 | Franchini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Genoveffa Franchini (Bethesda, Maryland); Marjorie Robert-Guroff (Rockville, Maryland); Daniel Howard Appella (Bethesda, Maryland); Sabrina Helmold Hait (Bethesda, Maryland); Mohammad Arif Rahman (Bethesda, Maryland); Massimiliano Bissa (Bethesda, Maryland); Ettore Appella (Bethesda, Maryland); Lisa M. Miller Jenkins (Bethesda, Maryland); Isabela Silva de Castro (Bethesda, Maryland); James D. Stamos (Bethesda, Maryland) |
| ABSTRACT | Methods are disclosed for inhibiting a HIV infection in a subject. These methods include administering to the subject an effective amount of a recombinant gp120 protein comprising a deletion of HIV-1 Envelope residues 137-152 according to the HXBc2 numbering system, or a nucleic acid molecule encoding the recombinant gp120 protein, wherein the recombinant gp120 protein elicits an immune response to HIV-1. The methods also include administering to the subject an effective amount of a SAMT-247 microbicide. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 18/681019 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/255 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16222 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277831 | King et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. King (Seattle, Washington); David Veesler (Seattle, Washington); Carl Walkey (Seattle, Washington); Alexandra C. Walls (Seattle, Washington); Jing Yang Wang (Seattle, Washington) |
| ABSTRACT | Disclosed herein are polypeptides comprising an amino acid sequence at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-84, 138-146, and 167-184, nanoparticles thereof, related nanoparticle compositions, and their use to treat or limit development of an infection. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/760174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/575 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277841 | BAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping BAO (West Lafayette, Indiana); Qing DENG (West Lafayette, Indiana); Yun CHANG (West Lafayette, Indiana); Ramizah MOHD SABRI (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a stage-specific process for manufacturing a population of neutrophils, such as chimeric antigen receptor-expressing (CAR-expressing) neutrophils (e.g., T cells and natural killer (NK) cells), from human pluripotent stem cells (hPSCs) using defined media and related compositions, kits, and methods of use (e.g., targeted cancer immunotherapy). Stage-specific processes for generating neutrophils and chimeric antigen receptor (CAR) neutrophils from human pluripotent stem cells (hPSCs) using chemically defined, feeder-free platforms and stage-specific morphogens; cell lines; pharmaceutical compositions; a method of treating cancer; and a kit are within the scopes of this disclosure. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 18/256916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/461 (20230501) Original (OR) Class A61K 39/4631 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/43522 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 15/85 (20130101) C12N 2501/15 (20130101) C12N 2501/22 (20130101) C12N 2501/26 (20130101) C12N 2501/125 (20130101) C12N 2501/165 (20130101) C12N 2501/385 (20130101) C12N 2501/2303 (20130101) C12N 2501/2306 (20130101) C12N 2506/03 (20130101) C12N 2800/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277852 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Nathanael S. Gray (Stanford, California); Mingxing Teng (Boston, Massachusetts); Eric Wang (Brookline, Massachusetts); Jie Jiang (Brookline, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Lewis C. Cantley (Cambridge, Massachusetts); Eric S. Fischer (Chestnut Hill, Massachusetts); Katherine A. Donovan (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates to compounds, compositions, and methods for treating diseases or conditions by modulating (e.g., reducing) the level or activity of at least one of PIP4K2A, PIP4K2B, and PIP4K2C. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 18/559655 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/5383 (20130101) A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) Heterocyclic Compounds C07D 239/42 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 409/04 (20130101) C07D 409/10 (20130101) C07D 417/04 (20130101) C07D 498/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277854 | Blake et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. Blake (Stanford, California); Paul Wender (Stanford, California); Robert Waymouth (Stanford, California); Ronald Levy (Stanford, California); Ole Haabeth (Stanford, California); Rebecca Mcclellan (Stanford, California); Adrienne Sallets (Stanford, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 47/549 (20170801) A61K 47/593 (20170801) Original (OR) Class A61K 48/0041 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) C08G 63/64 (20130101) C08G 63/685 (20130101) C08G 73/028 (20130101) C08G 73/0293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277862 | ZHANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong ZHANG (Los Angeles, California) |
| ABSTRACT | A poly ADP-ribose polymerase (PARP)-antibody conjugate including an automodified PARP having a plurality of poly ADP-ribose (ADPr) polymers, wherein the poly ADPr polymers comprise a plurality of 3′-azido ADP-ribose moieties; and one or more antibody molecules conjugated to one or more of the plurality of 3′-azido ADP-ribose moieties, wherein the one or more antibody molecules specifically bind to both a cancer cell surface marker protein and an immune cell surface marker protein, and wherein at least one of the plurality of 3′-azido ADP-ribose moieties is not conjugated to the antibody molecules. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/439252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 47/6815 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) C07K 16/2809 (20130101) Enzymes C12Y 204/02039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277868 | GORBUNOVA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | UNIVERSITY OF ROCHESTER (Rochester, New York); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| INVENTOR(S) | Vera GORBUNOVA (Honeoye Falls, New York); Andrei SELUANOV (Honeoye Falls, New York); Yousin SUH (New York, New York) |
| ABSTRACT | An isolated nucleic acid molecule encoding a variant of sirtuin 6 (SIRT6) having at least 75% identity with sequence SEQ ID NO: 1, the variant having at least one mutation selected from a N308K substitution and a A313S substitution with respect to sequence SEQ ID NO: 1. Also, means for the regulation of ageing, and/or senescence, and/or lifespan in an individual. Further, means for the repair of double strand breaks in a cell. Finally, means for the prevention and/or the treatment of an age-related disease. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 18/560828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 48/0016 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 39/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277870 | Waymouth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M Waymouth (Palo Alto, California); Paul Wender (Palo Alto, California); Jessica R. Vargas (Palo Alto, California); Tim R. Blake (Palo Alto, California); Colin J. McKinlay (Palo Alto, California); Ronald Levy (Palo Alto, California); Ole Audun Werner Haabeth (Palo Alto, California); Nancy Benner (Palo Alto, California); Katherine Near (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Tuesday, March 12, 2024 |
| APPL NO | 18/602410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) A61K 47/6883 (20170801) A61K 47/6907 (20170801) A61K 47/6931 (20170801) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/88 (20130101) C12N 15/115 (20130101) C12N 15/1135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277903 | Almarza et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Alejandro Almarza (Pittsburgh, Pennsylvania); Adam Chin (Pembroke Pines, Florida); Juan Toboas (Pittsburgh, Pennsylvania); Yadong Wang (Ithaca, New York) |
| ABSTRACT | The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639302 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/56 (20130101) A61L 27/446 (20130101) Original (OR) Class A61L 27/3817 (20130101) A61L 2430/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277928 | Epshteyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nuwellis, Inc. (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vitaliy Gennad’yevich Epshteyn (Maple Grove, Minnesota); Steven Daniel Sandoval (Eden Prairie, Minnesota); Kalley Francis Berg (Lino Lakes, Minnesota); Franz Willems Ulrich (Minneapolis, Minnesota) |
| ABSTRACT | An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298581 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/165 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277929 | Epshteyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nuwellis, Inc. (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vitaliy Gennad’yevich Epshteyn (Maple Grove, Minnesota); Steven Daniel Sandoval (Eden Prairie, Minnesota); Kalley Francis Berg (Lino Lakes, Minnesota); Franz Willems Ulrich (Minneapolis, Minnesota) |
| ABSTRACT | An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298617 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/165 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277930 | Epshteyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nuwellis, Inc. (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vitaliy Gennad’yevich Epshteyn (Maple Grove, Minnesota); Steven Daniel Sandoval (Eden Prairie, Minnesota); Kalley Francis Berg (Lino Lakes, Minnesota); Franz Willems Ulrich (Minneapolis, Minnesota) |
| ABSTRACT | An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298810 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/165 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277931 | Epshteyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nuwellis, Inc. (Eden Prairie, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vitaliy Gennad’yevich Epshteyn (Maple Grove, Minnesota); Steven Daniel Sandoval (Eden Prairie, Minnesota); Kalley Francis Berg (Lino Lakes, Minnesota); Franz Willems Ulrich (Minneapolis, Minnesota) |
| ABSTRACT | An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale. |
| FILED | Tuesday, April 11, 2023 |
| APPL NO | 18/298860 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/165 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278242 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon LEE (Wynnewood, Pennsylvania); Junhyong KIM (Narberth, Pennsylvania); Paradorn RUMMANEETHORN (Philadelphia, Pennsylvania) |
| ABSTRACT | Here we demonstrate a contactless method to induce reversible droplet contact angle modulation on chemically inert substrates via corona discharge-based dielectric charge injection (DCI). The method involves a probe that can induce dielectric breakdown of the surrounding dielectric medium, such as air, under voltages exceeding the medium's dielectric strength. Breakdown leads to ionization of the dielectric, after which then the ions accelerate away from the sharp tip due to electrostatic repulsion, resulting in charge injection onto a target surface. With DCI, one induces wetting of a water droplet on non-wetting, non-contacting surfaces in non-polar continuous phases. DCI can achieve up to 140° contact angle modulation. Furthermore, upon removal of the voltage, the droplet dewets and returns to the initial non-wetting state. DCI can induce deposition of encapsulated materials from droplets to the non-wetting surface. DCI can also recover materials from such a surface. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570153 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502792 (20130101) Original (OR) Class B01L 2300/16 (20130101) B01L 2300/0645 (20130101) B01L 2400/0424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279174 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Pei Zhou (Durham, North Carolina); Jiyong Hong (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are novel antibiotic compositions and methods of making and using the same. The antibiotic compositions may comprise LPXH-targeting compounds. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/626187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/551 (20130101) A61K 31/706 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 209/08 (20130101) Original (OR) Class C07D 213/72 (20130101) C07D 213/89 (20130101) C07D 249/04 (20130101) C07D 261/18 (20130101) C07D 295/26 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279191 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xu Wu (Lexington, Massachusetts); Lu Hu (Malden, Massachusetts) |
| ABSTRACT | The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, compositions comprising same, and methods of using the compounds and compositions to treat various cancers. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 18/694815 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 211/22 (20130101) C07D 213/30 (20130101) C07D 213/75 (20130101) C07D 239/42 (20130101) C07D 249/06 (20130101) C07D 295/26 (20130101) C07D 295/192 (20130101) Original (OR) Class C07D 305/08 (20130101) C07D 309/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279206 | Lennek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tosk, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Annie L. Lennek (Mountain View, California); Stephen D. Yanofsky (Mountain View, California); Brian D. Frenzel (Mountain View, California); Solomon B. Ungashe (Mountain View, California); William A. Garland (Mountain View, California); Philip Liaw (Mountain View, California) |
| ABSTRACT | RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. |
| FILED | Tuesday, February 13, 2024 |
| APPL NO | 18/440763 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) Original (OR) Class C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279232 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander E. Arnold (Milwaukee, Wisconsin); Douglas C. Stafford (Stoughton, Wisconsin); James M. Cook (Milwaukee, Wisconsin); Amanda N. Nieman (Hartford, Wisconsin); Michael Ming-Jin Poe (Fitchberg, Wisconsin); Guanguan Li (Shenzhen, Guangdong Province, China PRC) |
| ABSTRACT | Substituted 5-(4-methyl-6-phenyl-4H-benzo[f]imidazo[1,5-a][1.4]diazepin-3-yl)-1.2.4-oxadiazole compounds are ligands for the k opioid receptor and inhibit inducible nitric oxide synthase. The compounds have utility to inhibit NO production and treat associated inflammatory conditions. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/567191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5517 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240279285 — Rippled Antiparallel Cross-Beta Dimers and Related Materials, Compositions and Methods
| US 20240279285 | Raskatov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jevgenij A. Raskatov (Santa Cruz, California) |
| ABSTRACT | Provided are rippled antiparallel cross-β dimers. In some embodiments, the dimers comprise (L,L,L)-(FX1F)k dimerized with (D,D,D)-(FX2F)k, where X1 and X2 are independently selected from any amino acid, and wherein k is an integer of 1 or greater. Also provided are rippled β-sheet fibrils comprising a plurality of the rippled antiparallel cross-β dimers of the present disclosure. Materials comprising the rippled antiparallel cross-β dimers and rippled β-sheet fibrils of the present disclosure are also provided, as are compositions comprising such materials. Also provided are methods of making the rippled antiparallel cross-β dimers and rippled β-sheet fibrils of the present disclosure. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570390 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279295 | CHACKERIAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bryce CHACKERIAN (Albuquerque, New Mexico); Kiran BHASKAR (Albuquerque, New Mexico); Jonathan P. HULSE (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryce CHACKERIAN (Albuquerque, New Mexico); Kiran BHASKAR (Albuquerque, New Mexico); Jonathan P. HULSE (Albuquerque, New Mexico) |
| ABSTRACT | An immunogen includes an immunogenic carrier and an antigenic apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) peptide linked to the immunogenic carrier. In one or more embodiments, the immunogenic carrier is a Qβ virus-like particle (VLP). The immunogen may be formulated into a composition useful for treating inflammatory medical conditions. |
| FILED | Tuesday, April 16, 2024 |
| APPL NO | 18/637070 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00115 (20180801) A61K 2039/5258 (20130101) Peptides C07K 14/4747 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2795/18123 (20130101) C12N 2795/18134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279307 | BLEAKLEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie BLEAKLEY (Seattle, Washington); Robson DOSSA (Seattle, Washington); Daniel SOMMERMEYER (Munich, Germany) |
| ABSTRACT | The present disclosure provides compositions and methods for targeting a minor histocompatibility (H) antigen (HA-1H) to, for example, prevent or manage relapse of a hematological malignancy after allogeneic hematopoietic stem cell transplantation (HCT). Also provided are transgene constructs encoding engineered binding proteins, such as a T cell receptor or a chimeric antigen receptor, optionally encoding additional components such as a co-receptor and/or safety switch. Such transgene constructs can be transduced into an immune cell, such as a T cell, and used as an immunotherapy in a subject having a hematological malignancy or at risk for recurrence of the hematological malignancy (e.g., leukemia, lymphoma, myeloma). |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/456389 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70596 (20130101) C07K 2319/40 (20130101) C07K 2319/41 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279314 | Ravetch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Ravetch (New York, New York); Falk Nimmerjahn (Erlangen, Germany); Yoshikatsu Kaneko (New York, New York) |
| ABSTRACT | The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody. |
| FILED | Wednesday, March 27, 2024 |
| APPL NO | 18/618981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/68 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) Original (OR) Class C07K 16/06 (20130101) C07K 16/18 (20130101) C07K 2317/41 (20130101) C07K 2317/52 (20130101) C07K 2317/71 (20130101) C07K 2317/76 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279331 | Wells et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | James A. Wells (San Francisco, California); Emily Kang (San Francisco, California); Lewis L. Lanier (San Francisco, California) |
| ABSTRACT | A functional screen to rapidly identify antibodies that can activate NK cells is provided as well as antibodies identified in the screen and their use. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568218 |
| CURRENT CPC | Peptides C07K 16/32 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279504 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Shaoyi Jiang (Seattle, Washington); Xiaojie Lin (Seattle, Washington); Jonathan Himmelfarb (Seattle, Washington); Buddy D. Ratner (Seattle, Washington) |
| ABSTRACT | Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/465867 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/06 (20130101) A61L 29/041 (20130101) A61L 29/085 (20130101) A61L 29/141 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/28 (20130101) C08J 2333/26 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279600 | Studer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Lorenz Studer (New York, New York); Emiliano Hergenreder (New York, New York); Gabriele Clceri (New York, New York) |
| ABSTRACT | The present disclosure provides compositions, kits, and methods for promoting in vitro maturation of cells. The present disclosure also provides methods of screening compounds that are suitable for promoting in vitro maturation of cells. |
| FILED | Friday, April 26, 2024 |
| APPL NO | 18/647342 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) Original (OR) Class C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279601 | STUDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York) |
| ASSIGNEE(S) | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL SLOAN-KETTERING CANCER CENTER (Nnew York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York) |
| INVENTOR(S) | Lorenz STUDER (New York, New York); Yujie Fan (New York, New York) |
| ABSTRACT | The present disclosure relates to methods for generating sacral neural crest lineage cells and enteric neurons. Also provided are sacral neural crest lineage cells and enteric neurons generated by the presently disclosed methods and compositions comprising such cells. The present disclosure further provides uses of the sacral neural crest lineage cells and enteric neurons for preventing, modeling, and/or treating of enteric nervous system disorders. |
| FILED | Friday, December 15, 2023 |
| APPL NO | 18/542134 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/19 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279619 | ROHWER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forest ROHWER (San Diego, California); Jeremy J. BARR (San Diego, California) |
| ABSTRACT | Provided are compositions and methods for treating, ameliorating and preventing infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor. Provided are compositions and methods used to treat, prevent or ameliorate an infection, for example, an infection in the gastrointestinal tract, or bowel. Provided are compositions and methods for treating, ameliorating and/or preventing a condition comprising an abnormal, disrupted or pathological mucosal surface or mucus-covered epithelium, or a condition caused, modified or effected by an abnormal, disrupted or pathological microbiotia, wherein optionally the infection or condition comprises a diarrhea, a colitis, obesity, diabetes, autism, a cystic fibrosis, a dysentery, a gastrointestinal infection, a gastrointestinal inflammation, a gastrointestinal dysbiosis, a gastrointestinal upset, a lung infection, a bacterial infection, a viral infection, a secondary infection, an inflammation, a mucus hypersecretion, or a dysbiosis. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/642329 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/005 (20130101) C07K 2319/035 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2795/00021 (20130101) C12N 2795/00022 (20130101) C12N 2795/00031 (20130101) C12N 2795/00033 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279623 | Neumann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin Neumann (Somerville, Massachusetts); Tessa Bertozzi (Cambridge, Massachusetts); Jonathan Weissman (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/444590 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Peptides C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1007 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 201/01037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279628 | Gersbach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles A. Gersbach (Chapel Hill, North Carolina); Pratiksha I. Thakore (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use. |
| FILED | Friday, January 05, 2024 |
| APPL NO | 18/405995 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 48/00 (20130101) A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Peptides C07K 14/4703 (20130101) C07K 2319/09 (20130101) C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/52 (20130101) C12N 15/63 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279629 | Sternberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Henry Sternberg (New York, New York); George Davis Lampe (New York, New York); Rebeca Teresa King Davidson (New York, New York); Alejandro Chavez (New York, New York); Sanne Eveline Klompe (New York, New York) |
| ABSTRACT | The present disclosure provides systems, kits, and methods for nucleic acid integration utilizing engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated transposon (CRISPR-Tn) system. More particularly, the present disclosure provides systems comprising: an engineered CRISPR-Tn system or one or more nucleic acids encoding the engineered CRISPR-Tn system, wherein the CRISPR-Tn system comprises at least one or both of: a) at least one Cas protein (e.g., Cas6, Cas7, Cas5, and/or Cas8); and b) one or more transposon-associated proteins (e.g., TnsA, TnsB, TnsC, TnsD, and/or TniQ). The present disclosure also provides systems, kits, and methods for nucleic acid integration in a eukaryotic cell. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/567617 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/90 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279649 | Miao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Carol Hsing Miao (Seattle, Washington) |
| ABSTRACT | Gene-editing to allow for expression of functional factor VIII for the treatment of hemophilia A is described. The disclosure further provides nanoparticles to deliver gene-editing components to liver sinusoidal endothelial cells (LSEC) to correct mutant factor VIII genes. |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/290433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) A61K 48/0041 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/88 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279657 | ZENNADI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rahima ZENNADI (Durham, North Carolina); Brittany ELLIOTT (Durham, North Carolina); Christopher HOLLEY (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes, in part, compositions and method for the prevention and treatment of hemoglobinopathies, including sickle cell disease by inhibition or decreasing production, expression or activity of Rpl13 snoRNAs. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 18/570967 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279660 | Jo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanjoong Jo (Atlanta, Georgia); Joan Fernandez Esmerats (Atlanta, Georgia); Nicolas Villa-Roel (Brookhaven, Georgia) |
| ABSTRACT | This disclosure relates to the use of miRNA-483 and its target genes, UBE2C, pVHL and HIF1alpha, in managing the treatment of cardiovascular and inflammatory diseases. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a miR-483 mimic and/or an HIF inhibitor and a pharmaceutically acceptable excipient for use in treating or preventing a vascular disease or condition. In certain embodiments, the miR-483 mimic is a double stranded nucleobase polymer or an expression vector that expresses mature human miR-483-5p and miR-483-3p sequences or operable fragments and variants. |
| FILED | Friday, April 05, 2024 |
| APPL NO | 18/628412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/3231 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279661 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Texas Heart Institute (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas); Texas Heart Institute (Houston, Texas) |
| INVENTOR(S) | James F. Martin (Pearland, Texas); Yuka Morikawa (Houston, Texas); Todd Ryan Heallen (Houston, Texas); John P. Leach (Pearland, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed. |
| FILED | Thursday, April 11, 2024 |
| APPL NO | 18/633108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) C12N 2740/15043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279665 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbing Zhao (Lumberton, New Jersey); Jiangtao Ren (Philadelphia, Pennsylvania); Xiaojun Liu (Swarthmore, Pennsylvania); Carl H. June (Merion Station, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease. |
| FILED | Friday, September 15, 2023 |
| APPL NO | 18/468043 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/26 (20130101) A61K 39/001102 (20180801) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2501/48 (20130101) C12N 2501/515 (20130101) C12N 2501/599 (20130101) C12N 2501/998 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279677 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Luhan Yang (Somerville, Massachusetts) |
| ABSTRACT | A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/619354 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/81 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 15/1024 (20130101) C12N 15/8201 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2810/55 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279687 | Economos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Economos (New Haven, Connecticut); Elias Quijano (Durham, Connecticut); Peter Glazer (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods for modulating the localization and/or activity of CRISPR/Cas systems are provided. Typically, the compositions include a single stranded peptide nucleic acid (ssPNA) oligomer having a nucleobase sequence that hybridizes to part or all of the spacer sequence of CRISPR RNA such as a crRNA, gRNA, sgRNA, etc., to form a PNA:RNA duplex. The methods typically include contacting the cells with an effective amount of the ssPNA oligomer in conjunction with the elements of a CRISPR/Cas system to modify CRISPR/Cas activity at a desired target. Strategies and methods of use there for using the compositions to modulate on-target and/or off-target editing are provided. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/567662 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/113 (20130101) C12N 2310/3181 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279695 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley S. Moore (La Jolla, California); Jonathan R. Chekan (La Jolla, California); Shaun M. K. McKinnie (La Jolla, California) |
| ABSTRACT | Provided herein are compounds of Formulas (la), (lb), (II) to (VIII), and salts thereof, and methods of making the same. Also provided herein are recombinant proteins useful in the production of compounds disclosed herein, polynucleotides encoding the same, and cells comprising the same. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/298464 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/1085 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/188 (20130101) Original (OR) Class Enzymes C12Y 114/11 (20130101) C12Y 205/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279718 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changchun LIU (Farmington, Connecticut); Xiong DING (Farmington, Connecticut) |
| ABSTRACT | The disclosure provides methods and compositions for All-In-One Dual CRISPR-Cas12a (termed “AIOD-CRISPR”) permit simple, rapid, ultrasensitive, specific, one-pot and visual detection of nucleic acids (DNA and RNA). |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/760126 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279720 | Wellstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia) |
| INVENTOR(S) | Anton Wellstein (Washington, District of Columbia); Megan E. McNamara (Washington, District of Columbia); Alexander H.K. Kroemer (Arlington, Virginia) |
| ABSTRACT | A method of detecting donor cell death in a subject receiving foreign biological material from a donor. The method comprises sequencing cfDNA in a biospecimen from the subject; determining cellular origin of the cfDNA by identifying methylation patterns in the sequence of the cfDNA and comparing the methylation patterns in the sequence of the cfDNA to known methylation patterns associated with different cell types; and determining source origin of the cfDNA by genotyping the cfDNA and identifying whether the cfDNA originates from the foreign biological material or from the subject. Cell death is detected when the cfDNA has both a cellular origin of the type of foreign biological material that was received from the donor, and a source origin of the donor. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 18/291091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6881 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279741 | Goel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cancer Diagnostics Research Innovations (Colleyville, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay Goel (Colleyville, Texas); Daisuke Izumi (Colleyville, Texas) |
| ABSTRACT | A kit for diagnosing gastric cancer in a patient, the kit including nucleic acid probes for detecting elevated levels of expression of a group of micro RNA molecules in a biological sample from the patient. The group of micro RNA molecules consists of miR-18a, miR-21, miR-181a, miR-181b, miR-196a, miR-196b, and miR-146b. The elevated levels of expression are relative to the expression level of a same group of micro RNA molecules in a control biological sample. |
| FILED | Monday, July 10, 2023 |
| APPL NO | 18/349807 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279754 | RAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); ISS Inc. (Champaign, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishanu RAY (Ellicott City, Maryland); Anthony L. DEVICO (Alexandria, Virginia); Beniamino BARBIERI (Champaign, Illinois); Yuansheng SUN (Champaign, Illinois) |
| ABSTRACT | A fluorescence-based analytical platform comprising methods, software and instrumentation that accomplishes direct, rapid, high throughput, multiplex, and quantitative determinations of virion populations, in human or animals or experimental fluids, that are impacted by, or escape from, interactions with antiviral drugs. The platform can be used to advance bnAb resistance detection capacities to support numerous bnAb clinical trial activities, from screening volunteers to tailoring subject-specific bnAb combinations for treatment or cure. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443665 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) C12Q 1/703 (20130101) Original (OR) Class C12Q 1/6818 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280158 | Camarillo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Savior Brain Inc. (Arlington, Virginia); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Benjamin Camarillo (Stanford, California); Daniel James Faulkner (Portland, Oregon); Nicholas James Cecchi (Anaheim, California); Jeffrey Allison (Lake Oswego, Oregon) |
| ABSTRACT | A shock absorbing device is disclosed comprising a first collapsible chamber having a first reservoir space, a first wall configured to receive an impact force, and a first orifice configured to eject a fluid from the first reservoir space in reaction to the impact force; and a second collapsible chamber having a second reservoir space, a second wall configured to receive at least a portion of the impact force, a second orifice in communication with the first orifice and the second reservoir space, and at least one ejection orifice in communication with the second reservoir space and configured to eject the fluid from the second reservoir space in reaction to the said received at least a portion of the impact force. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/569097 |
| CURRENT CPC | Hats; Head Coverings A42B 3/12 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280563 | Tarasov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail Tarasov (Columbus, Ohio); Przemyslaw Radwanski (Columbus, Ohio) |
| ABSTRACT | Systems and methods for ion channel kinetics analysis in clusters of ion channels are described herein. In some implementations, the techniques described herein relate to a computer-implemented method including: receiving a multichannel activity signal associated with a plurality of ion channels of a cell; processing the multichannel activity signal to remove a capacitive transient; and analyzing the processed multichannel activity signal to assess cooperative ion channel gating behavior for the plurality of ion channels. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442534 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) Original (OR) Class Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280564 | Akassoglou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Mark Petersen (San Francisco, California); Anke Meyer-Franke (Menlo Park, California) |
| ABSTRACT | A high-throughput, high-content assay to screen for an agent which overcomes remyelination inhibition by an extrinsic inhibitor. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/566782 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0622 (20130101) C12N 2501/13 (20130101) C12N 2501/135 (20130101) C12N 2506/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5026 (20130101) G01N 33/5058 (20130101) Original (OR) Class G01N 33/5073 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280573 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rong Fan (Pasadena, California); Habib Ahmad (Los Angeles, California); James R. Heath (South Pasadena, California) |
| ABSTRACT | Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems. |
| FILED | Tuesday, September 19, 2023 |
| APPL NO | 18/469907 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/0074 (20130101) B01J 2219/00547 (20130101) B01J 2219/00596 (20130101) B01J 2219/00605 (20130101) B01J 2219/00621 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5025 (20130101) B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 2300/0636 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/084 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/54366 (20130101) G01N 33/54393 (20130101) Original (OR) Class G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280590 | Chamberlain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joel R. Chamberlain (Seattle, Washington); Jan Christian Lood (Seattle, Washington) |
| ABSTRACT | Methods and compositions for diagnosing or detecting Facioscapulohumeral Dystrophy (FSHD) are provided. One aspect provides a method for the evaluation of risk, progression, and therapeutic response of FSHD in human subjects. The method includes measuring/detecting an overall expression pattern or expression level of neutrophil extracellular traps (NETs) in one or more biological samples obtained from the subject and comparing the measured levels of these NETs to overall expression pattern or level of the neutrophil extracellular traps (NETs) from a biological sample of a normal subject. The method further comprises detecting the expression level of a mitochondrial protein in the one or more biological samples of the subject. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/582346 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281500 | DURR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Nicholas J. DURR (Baltimore, Maryland); Taylor L. BOBROW (Chesapeake, Virginia); Faisal MAHMOOD (Baltimore, Maryland) |
| ABSTRACT | A device may receive a coherent energy illuminated image, of a particular object, that includes laser speckle. The device may process, using a laser speckle reduction model, the coherent energy illuminated image to generate a laser speckle-reduced image. The device may provide the laser speckle-reduced image as output to permit diagnostics based on the laser speckle-reduced image. |
| FILED | Thursday, April 11, 2024 |
| APPL NO | 18/632463 |
| CURRENT CPC | Electric Digital Data Processing G06F 18/24 (20230101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/088 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281639 | Atlas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Covid Detection Foundation d/b/a Virufy (Los Altos, California) |
| ASSIGNEE(S) | The Covid Detection Foundation d/b/a Virufy (Los Altos, California); University of Washington (Seattle, Washington); Stanford University (Stanford, California) |
| INVENTOR(S) | Les Atlas (Seattle, Washington); Ankit Virmani (Seattle, Washington); Nicholas R. Rasmussen (Sioux Falls, South Dakota); Mert Pilanci (Los Altos, California); Felix Schwock (Seattle, Washington) |
| ABSTRACT | Provided is a method including obtaining time-series data; computing a transform of the time-series data; performing, with a complex clipping algorithm, a complex clipping operation of the transform of the time-series data to obtain a clipped data representation of the transform; classifying, using a classifier, the time-series data based on the clipped data representation; and storing a result of the classifying in memory. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584936 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281966 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/620830 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282409 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Tao WANG (Coppell, Texas); Yi Han (Dallas, Texas); Tianshi Lu (Dallas, Texas); Yuqiu Yang (Dallas, Texas) |
| ABSTRACT | The disclosed technology relates to a computer-implemented method for predicting T cell receptor (TCR) binding specificities towards T cell antigen targets (namely, peptide-major histocompatibility complexes, pMHCs), and a set of extensions of this method, include prediction of immune-related adverse events (irAEs) using a machine learning model. The method involves obtaining genomic and proteomic data from patients, determining TCR and pMHC sequences by analyzing these data, and predicting binding interactions between T cell antigens and the TCRs. The extensions include: (a) a transfer learning model for improving the predictive performance of a pre-trained TCR-antigen binding model as a foundation model, to enhance prediction for a specific pMHC, (b) a biomarker metric defined based on the output of the TCR-pMHC binding prediction method, for diagnosis, prognosis and response prediction purposes, (c) a method, based on the output of the TCR-pMHC binding prediction method, to select optimal antigens for tumor vaccines. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650820 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 25/10 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282549 | Axelrod et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Axelrod (Berkeley, California); Carter Turnbaugh (Berkeley, California); Sara Campbell (El Cerrito, California); Osip Schwartz (Albany, California); Robert M. Glaeser (Berkeley, California); Holger Mueller (Orinda, California) |
| ABSTRACT | A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first mirror and a second mirror that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light. |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/634129 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/22 (20130101) Original (OR) Class H01J 2237/2482 (20130101) H01J 2237/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240277587 | Krishna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vijay Krishna (Cleveland Heights, Ohio); Sanjay Anand (Cleveland, Ohio); Edward Maytin (Cleveland, Ohio); Stephen Grobmyer (Cleveland, Ohio) |
| ABSTRACT | The complete disclosure of all patents, patent applications, and publications, and electronically available material cited herein are incorporated by reference. The foregoing detailed description and examples have been given for clarity of understanding only. No unnecessary limitations are to be understood therefrom. The invention is not limited to the exact details shown and described, for variations obvious to one skilled in the art will be included within the invention defined by the claims. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/635154 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/11 (20130101) A61K 8/19 (20130101) Original (OR) Class A61K 8/44 (20130101) A61K 2800/56 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277616 | Whitehead et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kathryn Ann Whitehead (Pittsburgh, Pennsylvania); Jilian Melamed (Pittsburgh, Pennsylvania) |
| ABSTRACT | Lipid-containing particles and formulations containing the lipid-containing particles are provided. Methods of delivery of therapeutic agents to the pancreas using the lipid-containing particles are provided. |
| FILED | Friday, May 06, 2022 |
| APPL NO | 18/289661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 31/711 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277764 | METELITSA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Leonid S. METELITSA (Sugar Land, Texas); Daofeng LIU (Houston, Texas); Gianpietro DOTTI (Houston, Texas); Andras HECZEY (Houston, Texas) |
| ABSTRACT | The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/449841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 31/4545 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 39/0011 (20130101) A61K 39/001171 (20180801) A61K 45/06 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/55527 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) C12N 2500/02 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277829 | Franchini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | THE U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Genoveffa Franchini (Bethesda, Maryland); Marjorie Robert-Guroff (Rockville, Maryland); Daniel Howard Appella (Bethesda, Maryland); Sabrina Helmold Hait (Bethesda, Maryland); Mohammad Arif Rahman (Bethesda, Maryland); Massimiliano Bissa (Bethesda, Maryland); Ettore Appella (Bethesda, Maryland); Lisa M. Miller Jenkins (Bethesda, Maryland); Isabela Silva de Castro (Bethesda, Maryland); James D. Stamos (Bethesda, Maryland) |
| ABSTRACT | Methods are disclosed for inhibiting a HIV infection in a subject. These methods include administering to the subject an effective amount of a recombinant gp120 protein comprising a deletion of HIV-1 Envelope residues 137-152 according to the HXBc2 numbering system, or a nucleic acid molecule encoding the recombinant gp120 protein, wherein the recombinant gp120 protein elicits an immune response to HIV-1. The methods also include administering to the subject an effective amount of a SAMT-247 microbicide. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 18/681019 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/255 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 2039/54 (20130101) A61K 2039/55505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 37/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16171 (20130101) C12N 2740/16222 (20130101) C12N 2740/16234 (20130101) C12N 2740/16271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277901 | Cullen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Mary Hitchcock Memorial Hospital, for itself and on behalf of Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Kacy Cullen (Media, Pennsylvania); Justin C. Burrell (Philadelphia, Pennsylvania); Joseph M. Rosen (Lyme, New Hampshire) |
| ABSTRACT | In various aspects and embodiments, the invention provides a tissue engineered neuromuscular interface comprising: an extracellular matrix core; the extracellular matrix core comprising: a population of neurons at a first end of the extracellular matrix core, the population of neurons having axons extending at least a portion of the way along the extracellular matrix core; wherein the population of neurons is selected from the group consisting of one or more motor neurons, one or more motor neurons co-cultured with one or more sensory neurons, and a co-aggregate comprising one or more motor neurons and one or more sensory neurons. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/568560 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 27/3878 (20130101) Original (OR) Class A61L 2430/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277912 | BRUGGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| ASSIGNEE(S) | NxStage Medical, Inc. (Lawrence, Massachusetts) |
| INVENTOR(S) | James M. BRUGGER (Newburyport, Massachusetts); David DESOUZA (Essex, Massachusetts) |
| ABSTRACT | Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized. |
| FILED | Thursday, April 04, 2024 |
| APPL NO | 18/626465 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3629 (20140204) A61M 1/3643 (20130101) Original (OR) Class A61M 1/3644 (20140204) A61M 1/3646 (20140204) A61M 1/3652 (20140204) A61M 1/3672 (20130101) A61M 39/10 (20130101) A61M 2205/702 (20130101) A61M 2205/705 (20130101) A61M 2205/707 (20130101) A61M 2205/3331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278011 | Grover et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pulkit Grover (Pittsburgh, Pennsylvania); CHAITANYA GOSWAMI (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a method for optimizing electrode placement that directly exploits the thresholding phenomenon of neurons. The method employs a loss function which only becomes non-zero when the electric field is above a user-specified threshold in the cancel region, thereby allowing for fields which can have significant non-zero current in the cancel region, but still provide more focused neural activation. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 18/021257 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0404 (20130101) A61N 1/36014 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278293 | Dhau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Molekule, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaspreet S. Dhau (San Francisco, California); Chatura Wickramaratne (San Francisco, California) |
| ABSTRACT | A system for removing a coating from an underlying layer can include a wave-based weakening system configured to weaken the coating by decreasing a coupling force between the coating and the substrate, a coating removal mechanism configured to remove the weakened coating from the underlying layer, and a sensor configured to determine a property associated with the coating. A method for removing a coating from an underlying layer can include generating a weakened coating and removing the weakened coating. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/648500 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 7/04 (20130101) B08B 7/005 (20130101) Original (OR) Class B08B 7/026 (20130101) B08B 7/028 (20130101) B08B 7/0071 (20130101) B08B 13/00 (20130101) B08B 2220/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278423 | Ciocarlie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matei Ciocarlie (New York, New York); Gagan Khandate (New York, New York); Maximilian Haas-Heger (New York, New York) |
| ABSTRACT | A system for generating a model-free reinforcement learning policy for a robotic hand for grasping an object is provided, including a processor; a memory; and a simulator implemented via the processor and the memory, performing: sampling a plurality of stable grasps relevant to reorienting the grasped object about a desired axis of rotation and using stable grasps as initial states for collecting training trajectories; learning finger-gaiting and finger-grasping policies for each axis of rotation in the hand coordinate frame based on proprioceptive sensing in the robotic hand, wherein the finger-gaiting and finger-pivoting policy is implemented on the robotic hand. |
| FILED | Friday, March 22, 2024 |
| APPL NO | 18/613576 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 9/1612 (20130101) B25J 9/1671 (20130101) B25J 15/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278501 | Christian |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research in Acoustics LLC (Madison, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Wesley Christian (Madison, Virginia) |
| ABSTRACT | An aerosol evacuation system includes an intake proximate to a nozzle of an additive manufacturing system and arranged to receive a volume of air local to an outlet of the nozzle. The aerosol evacuation system also includes a conduit connected to the intake and arranged to define a passageway for airflow, a pump arranged to draw the airflow and particles emitted from the nozzle into the conduit through the intake, and a filtration system connected to the conduit and arranged to filter the airflow to remove ultrafine particles from the airflow. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/392781 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 64/245 (20170801) B29C 64/255 (20170801) B29C 64/295 (20170801) B29C 64/364 (20170801) Original (OR) Class B29C 64/393 (20170801) B29C 2791/004 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278510 | Seneviratne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wichita State University (Wichita, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waruna Seneviratne (Wichita, Kansas); Tharaka Nandakumara (Wichita, Kansas) |
| ABSTRACT | A tool for use with Automated Fiber Placement (AFP) machines and systems for use in in-process inspection of composite parts. The AFP system uses a robot, fiber guide, compaction roller, heating system, and an in-process inspection tool. The in-process inspection tool utilizes at least one profiler housed within a support bracket, which mounts the profiler on an AFP head of the AFP system such that the profiler does not interfere with the AFP layup, but outputs an in-process inspection signal representing a surface profile of a fiber strip as it is placed onto a molding for a composite part by the AFP head. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/444936 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/384 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) G01N 2021/8472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278513 | Boydston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Jackson Boydston (Middleton, Wisconsin); Jianxun Cui (Worcester, Massachusetts); Chang-Uk Lee (Verona, Wisconsin) |
| ABSTRACT | Methods for fabricating a resin object are provided. In embodiments. such a method comprises irradiating a curable composite with a focal spot of a focused ultrasound beam. the curable composite comprising a porous material having a solid matrix defining pores distributed throughout the solid matrix and a curable composition comprising prepolymers filling the pores. to form at least one cured region of polymer within the curable composite so as to provide a resin object comprising an interpenetrating network comprising the solid matrix of the porous material entangled with the polymer of the at least one cured region. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 18/576886 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/0261 (20130101) B29C 70/70 (20130101) B29C 71/04 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/08 (20130101) B29K 2105/04 (20130101) B29K 2105/0094 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278599 | Frizzell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew James Frizzell (Ballwin, Missouri); Richard Kurt Wagner (Crestwood, Missouri); Joseph Edward Flach (St. Charles, Missouri) |
| ABSTRACT | Caster assemblies are disclosed herein. An example caster assembly includes a caster frame assembly including a caster frame, a caster mounting plate, and a brake arm; a pin having a first end and a second end opposite the first end, the second end to engage the brake arm; and a lever arm having a third end and a fourth end opposite the third end, the lever arm to pivot relative to the caster frame assembly between a first position and a second position, movement of the lever arm to the first position to cause the fourth end of the lever arm to actuate the pin in a first direction to move the brake arm to the engaged position to restrict rotation of the wheel. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/170939 |
| CURRENT CPC | Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 33/021 (20130101) Original (OR) Class B60B 33/0081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278935 | Spruce |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Gregory Alan Spruce (Grand Prairie, Texas) |
| ABSTRACT | A fixture for installing a bearing race around a mast at a particular location is described. The fixture includes a plurality of vertical rails; a mast retention assembly positioned in between the plurality of rails and connected to inner surfaces of the rails, the mast retention assembly including a mast retention opening for receiving the mast therethrough, the mast retention assembly maintaining the mast in a vertical orientation when the mast is disposed through the mast retention opening; and a shuttle translatably connected to inner surfaces of the rails, the shuttle configured to retain the bearing race in a bearing race retention opening of the shuttle and to translate the bearing race from an upper end of the mast as the mast is disposed through the mast retention opening, wherein the mast passes through an inner opening of the bearing race, and to the particular position on the mast. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172837 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 29/0033 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/10 (20170101) Original (OR) Class Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 35/06 (20130101) F16C 43/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279109 | TOPPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Brian TOPPER (Albuquerque, New Mexico); Arash MAFI (Albuquerque, New Mexico); Johann Richard WEBER (Arlington Heights, Illinois); Stephen Kenneth WILKE (Evanston, Illinois) |
| ABSTRACT | According to examples of the present disclosure, a glass product is disclosed that includes a composition of which comprises at least 50 molar percent titanium dioxide and at least 0.1 molar percent rare earth metal oxide wherein the rare earth is at least one of the following elements: scandium, yttrium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443686 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 3/127 (20130101) Original (OR) Class C03C 4/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279282 | Fears et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Kenan Fears (Alexandria, Virginia); Manoj K. Kolel-Veetil (Annandale, Virginia); Olufolasade Atoyebi (Washington, District of Columbia); William A. Maza (Silver Spring, Maryland) |
| ABSTRACT | Disclosed is a cyclic peptide polymer having the below structure. Each R1 and each R2 is an organic group. Each R3 is a covalent bond or methylene. The values m and n are nonnegative integers having a sum of at least 1. Each X is —NH—CO— or —CO—N—. The value p is an integer greater than 1. The cyclic peptide polymer may be made by providing a cyclic peptide having two side chains having terminal amino groups or carboxylic acid groups, and reacting the amino groups with an azobenzene or the carboxylic acid groups with an azodianiline. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/433043 |
| CURRENT CPC | Peptides C07K 5/126 (20130101) C07K 7/64 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279414 | Ucak-Astarlioglu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by the Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mine G Ucak-Astarlioglu (Ridgeland, Mississippi); Hayden A Hanna (Lumberton, Mississippi); Michael J Grotke (Vicksburg, Mississippi); Zackery B Mcclelland (Clinton, Mississippi); Robert D Moser (Clinton, Mississippi) |
| ABSTRACT | A composite product includes basalt fibers and a liquid polymer resin mixed with a curing agent and infused into the basalt fibers. A method of making the composite product includes mixing a liquid polymer resin with a curing agent to form a resin matrix; infusing the resin matrix into basalt fibers; and curing the basalt fibers infused with the resin matrix to form the composite product. The method may further include adding an additive including at least one of graphene or graphite to the liquid polymer resin and the curing agent, and mixing the additive with them to form the resin matrix which is infused into the basalt fibers. It may further include weighing the additive, at about 0.1% to 0.3% of a weight of the liquid polymer resin and curing agent, to be added to the liquid polymer resin and curing agent. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/110784 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/30 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) B29K 2309/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/226 (20130101) C08G 59/245 (20130101) C08G 59/502 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/241 (20210501) Original (OR) Class C08J 5/249 (20210501) C08J 2363/02 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279551 | Abbott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas L. Abbott (Lansing, New York); Sangchul Roh (Ithaca, New York) |
| ABSTRACT | Compositions comprising liquid crystal composition(s) and isotropic liquid composition(s), and optionally, one or more salt(s) and methods of using same. In various examples, a composition is a bistable liquid crystalline emulsion. In various examples, a composition exhibits reversible emulsification and/or demulsification when subjected to an electric field. An optical device can comprise the composition(s). In various examples, device is an optical device, such as, for example, a light shutter, which may be a bistable light shutter or the like, a display, a television, a sensor, a window, which may be a smart window, an energy efficient window, a privacy window, or the like, a smart label, an electronic paper, an electrooptical device, or the like. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/568233 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/542 (20130101) Original (OR) Class C09K 2323/061 (20200801) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1391 (20130101) G02F 1/13743 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279645 | ELLINGTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew ELLINGTON (Austin, Texas); Simon D'OELSNITZ (Austin, Texas); Kamyab JAVANMARDI (Austin, Texas); Ross THYER (Houston, Texas) |
| ABSTRACT | Disclosed herein are engineered methyltransferases which are capable of methylating more than two sites in a benzylisoquinoline alkaloid or precursor thereof. Also disclosed are of methods of making benzylisoquinoline alkaloids using the engineered methyltransferase. Lastly, disclosed are kits, nucleic acids, and proteins related to the methyltransferases disclosed herein. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566018 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1072 (20130101) C12N 15/1086 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279740 | SUKUMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); RENMIN HOSPITAL OF WUHAN UNIVERSITY (Wuhan, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saraswati SUKUMAR (Columbia, Maryland); Bradley Downs (Omaha, Nebraska); Wanjun Ding (Wuhan, China PRC); Weiping Tao (Wuhan, China PRC) |
| ABSTRACT | Novel methods for diagnosing and treating diffuse large B-cell lymphoma (DLBCL) and/or primary central nervous system diffuse large B-cell lymphoma (PCNSL) are provided herein. The present invention provides a set of methylation markers which were identified in silico and confirmed in archival and tissue samples could achieve 100% accuracy to discriminate DLBCL and/or PCNSL from other CNS neoplasms. The markers can be identified using QM-MSP and a novel simpler, faster, qMSP assay called TAM-MSP. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 18/004030 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279822 | Zachariah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Michael R. Zachariah (Riverside, California); Prithwish Biswas (Riverside, California); Yujie Wang (Riverside, California) |
| ABSTRACT | A method, a system, and a non-transitory computer-readable medium for controlling flammability of a fuel. The method includes applying a voltage across a nonvolatile ionic liquid to convert the nonvolatile ionic liquid into a flammable liquid; and removing the applied voltage across the nonvolatile ionic liquid to revert the flammable liquid back to the nonvolatile ionic liquid. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442526 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/006 (20130101) C10L 2290/38 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/05 (20210101) C25B 3/09 (20210101) C25B 3/20 (20210101) Original (OR) Class C25B 15/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280068 | Mahaffy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EXQUADRUM, INC. (Victorville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin E. Mahaffy (Victorville, California); Mark Heiner (Victorville, California) |
| ABSTRACT | A rocket propulsion engine includes a propellant vessel, a sensitizer vessel, a combustion chamber, an exhaust nozzle, and a controllable sensitizer injector. The combustion chamber combusts combustible propellant received from the propellant vessel and the combustion gas produced therefrom is exhausted through the exhaust nozzle. When activated, the controllable sensitizer injector introduce sensitizer from the sensitizer vessel into the propellant vessel to form an explosive mixture of the combustible propellant and the sensitizer. A method of operating a rocket propulsion engine includes supplying a combustible propellant from the propellant vessel into the combustion chamber, combusting the combustible propellant within the combustion chamber, and exhausting combustion gas produced through the exhaust nozzle. The method also includes introducing the sensitizer from the sensitizer vessel into the propellant vessel to form an explosive mixture within the propellant vessel. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/443061 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/72 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280124 | Wiedemeier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon J. Wiedemeier (San Diego, California); Jeffrey M. Lloyd (San Diego, California); Salvador Serra (Spring Valley, California) |
| ABSTRACT | A pressure locking clamp includes a base, a hook arm, and a clasp arm. An imaginary central plane divides the base into a first and second half. The hook arm pivots on the first half of the base around a first axis parallel to the imaginary central plane. The clasp arm pivots on the second half of the base around a second axis parallel to the imaginary central plane. The hook and clasp arms each includes a lock contact area. In a closed state of the pressure locking clamp, the hook and clasp arms and the base together form an eye enclosure. In the closed state, pressure inside the eye enclosure presses the lock contact area of the clasp arm against the lock contact area of the hook arm, and this inhibits the hook and clasp arms from pivoting away from each other, reinforcing the eye enclosure. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/172135 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 2/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280424 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin Chen (San Antonio, Texas); Adam C. Cobb (San Antonio, Texas); Douglas R. Earnest (San Antonio, Texas); Clint J. Thwing (Bulverde, Texas); Nikolay Akimov (San Antonio, Texas) |
| ABSTRACT | A method for detecting residual stress induced by cold expansion (Cx) (Cx stress) at a hole in a structure. Two transducer pairs transmit and receive ultrasonic waves into the structure in a pitch-catch configuration along two first paths parallel to a tangent of the hole. The two paths are at different distances from the hole. Both transducer pairs are arranged such that their incident angle into the structure provides longitudinal critically refracted (LCR) waves within the structure. Time-of-flight (ToF) measurements of the LCR waves along the first path and the second path are the basis of acoustoelasticity calculations that determine if Cx stress is present at the hole. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581320 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/255 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/34 (20130101) G01N 29/223 (20130101) G01N 29/227 (20130101) G01N 29/4436 (20130101) G01N 2291/011 (20130101) G01N 2291/105 (20130101) G01N 2291/0234 (20130101) G01N 2291/0421 (20130101) G01N 2291/02827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280564 | Akassoglou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Mark Petersen (San Francisco, California); Anke Meyer-Franke (Menlo Park, California) |
| ABSTRACT | A high-throughput, high-content assay to screen for an agent which overcomes remyelination inhibition by an extrinsic inhibitor. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/566782 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0622 (20130101) C12N 2501/13 (20130101) C12N 2501/135 (20130101) C12N 2506/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5026 (20130101) G01N 33/5058 (20130101) Original (OR) Class G01N 33/5073 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280590 | Chamberlain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joel R. Chamberlain (Seattle, Washington); Jan Christian Lood (Seattle, Washington) |
| ABSTRACT | Methods and compositions for diagnosing or detecting Facioscapulohumeral Dystrophy (FSHD) are provided. One aspect provides a method for the evaluation of risk, progression, and therapeutic response of FSHD in human subjects. The method includes measuring/detecting an overall expression pattern or expression level of neutrophil extracellular traps (NETs) in one or more biological samples obtained from the subject and comparing the measured levels of these NETs to overall expression pattern or level of the neutrophil extracellular traps (NETs) from a biological sample of a normal subject. The method further comprises detecting the expression level of a mitochondrial protein in the one or more biological samples of the subject. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/582346 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280649 | de Andrade et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcio Calixto de Andrade (San Diego, California); Lee Lemay (San Diego, California) |
| ABSTRACT | An imager of a magnetic field includes a sensor array and a display. The sensor array includes sensor pixels, which each include at least one Josephson junction for generating an electrical signal responsive to a magnetic flux of the magnetic field through the sensor pixel. The display is coupled to the sensor array for displaying, for each of the sensor pixels, a respective strength from the electrical signal of the magnetic flux through the sensor pixel. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172489 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0354 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280720 | SOLOVIEV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NOVA SOUTHEASTERN UNIVERSITY, INC. (Fort Lauderdale, Florida) |
| ASSIGNEE(S) | NOVA SOUTHEASTERN UNIVERSITY, INC. (Fort Lauderdale, Florida) |
| INVENTOR(S) | Alexander V. SOLOVIEV (Fort Lauderdale, Florida); Cayla W. DEAN (Fort Lauderdale, Florida) |
| ABSTRACT | Systems and methods to detect ferromagnetic objects, particularly submerged, non-naturally occurring ferromagnetic objects, account for contributions to the magnetic field arising from topography, such as magnetic refraction at bathymetric slopes. Removing this topography component of noise from detected total magnetic field enhances detection capability of, for example, naval surveillance systems. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/569108 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/02 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/38 (20130101) G01V 3/081 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280776 | Taranta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Austin Acker Taranta (Southampton, United Kingdom); Leonard George Budd (Southampton, United Kingdom); Francesco Poletti (Southampton, United Kingdom); Eric Numkam Fokoua (Southampton, United Kingdom); Seyed Mohammad Abokhamis Mousavi (Portsmouth, United Kingdom) |
| ABSTRACT | Techniques are provided for controlling azimuthal alignment of a cross-section of the anti-resonant hollow core fiber when winding such anti-resonant hollow core fiber into a coil. |
| FILED | Friday, June 23, 2023 |
| APPL NO | 18/340713 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/444 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280881 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Samuel Douglass Wilson (Bloomington, Indiana); Matthew David Alley (Bloominaton, Indiana); Matthew Edward Cummings (Bedford, Indiana) |
| ABSTRACT | Provided is a weatherproof enclosure for an electro-optic infrared camera core with male lens threads and exposed electronics. The enclosure includes a lens cover with female threads, a front and rear main body, a first and second gasket, a cable gland opening in the rear main body, and mounting holes. The female threads attach to the male threads to secure the lens cover to the front main body. The gaskets create a weatherproof seal, and the cable gland opening enables power and data cabling to pass to the exterior of the enclosure. The mounting holes permit attachment to a variety of surfaces. An alternative internal compression bracket can be used to secure a variety of OEM camera modules that all utilize the same bolt pattern. The enclosure provides superior protection from water intrusion and impact forces, permitting camera use in austere environments. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/112551 |
| CURRENT CPC | Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 17/08 (20130101) Original (OR) Class G03B 17/12 (20130101) Pictorial Communication, e.g Television H04N 23/23 (20230101) H04N 23/51 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281539 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yinzhi Cao (Baltimore, Maryland); Mingqing Kang (Baltimore, Maryland); Song Li (Baltimore, Maryland); Jianwei Hou (Baltimore, Maryland) |
| ABSTRACT | Methods, systems, and computer programs for generating a data structure that represents features of object-oriented program code. In one aspect, the method includes actions of obtaining object-oriented program code, generating an abstract syntax tree based on the obtained object-orient program code, generating one or more graph nodes based on the semantics of the abstract syntax tree nodes, wherein each generated graph node corresponds to an object of the object-oriented program code, and generating one or more graph edges, wherein each generated graph edge: begins at a node of the abstract syntax tree and terminates at one of the generated graph nodes, and represents a use, by the object-oriented program code, of an object represented by the generated graph node where the generated graph edge terminates. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566938 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/577 (20130101) Original (OR) Class G06F 2221/033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281582 | BARKER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating timing libraries. The apparatus includes a memory and a processor. The processor determines a condition that indicates whether a superconducting electronic circuit design passes or fails logic verification and determines an edge-of-failure value for a timing parameter for the superconducting electronic circuit design. The processor simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a first process variation to produce a first timing value for the superconducting electronic circuit design and simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a second process variation to produce a second timing value for the superconducting electronic circuit design. The processor generates a timing library for the superconducting electronic circuit design based at least in part on the first timing value and the second timing value. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/110932 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3315 (20200101) Original (OR) Class G06F 2111/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281610 | Freitag |
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| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dayne Freitag (Descanso, California) |
| ABSTRACT | The machine learning in the neural networks module can analyze an annotation and its metadata on the annotation made by a first user on a first computing device to make an embedding regarding the annotation and then cooperate with the persistence knowledge store to store the embedding of the machine learning's understanding of the annotation and its metadata. The delivery module can proactively push a notice regarding a potentially related embedding out to a second user on a second computing device based on a threshold amount of relatedness between one or more factors of i) a first task undertaken by the first user and a second task undertaken by the second user, ii) a role of the first user and a role of the second user, and iii) a subject matter of the embedding to a subject matter of a task undertaken by the second user. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583631 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/101 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/55 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281635 | OLSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbot, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbot, Michigan) |
| INVENTOR(S) | Edwin OLSON (Ann Arbot, Michigan); Dhanvin H. MEHTA (Ann Arbot, Michigan); Gonzalo FERRER (Ann Arbot, Michigan) |
| ABSTRACT | In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed-even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653211 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Original (OR) Class G06N 3/008 (20130101) G06N 3/084 (20130101) G06N 7/01 (20230101) Pictorial Communication, e.g Television H04N 1/00002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281966 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey E. Thatcher (Irving, Texas); Peiran Quan (Dallas, Texas); Faliu Yi (Allen, Texas); Kevin Plant (Dallas, Texas); Ronald Baxter (Grand Prairie, Texas); Brian McCall (Dallas, Texas); Zhicun Gao (Plano, Texas); Jason Dwight (Dallas, Texas) |
| ABSTRACT | Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval. |
| FILED | Thursday, March 28, 2024 |
| APPL NO | 18/620830 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/445 (20130101) A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30088 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282906 | DeBlock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ryan H. DeBlock (Alexandria, Virginia); Debra R. Rolison (Arlington, Virginia); Jeffrey W. Long (Alexandria, Virginia); Zachary G. Neale (Alexandria, Virginia) |
| ABSTRACT | A method of making an electrode by providing a mixture of first particles of silver or silver oxide and second particles of an inorganic porogen, molding the mixture, cohering the mixture to form a green body, demolding the green body, heating the green body to form a monolith, to convert any silver oxide to silver, and to fuse the first particles together, and submerging the monolith in a liquid that removes the second particles. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650512 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/0433 (20130101) Original (OR) Class H01M 10/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240277245 | Davalos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael V. Davalos (Aptos, California); Mohammad Bonakdar (Medford, Massachusetts); Eduardo L. Latouche (Chelsea, Massachusetts); Roop L. Mahajan (Fairfax, Virginia); John L. Robertson (Floyd, Virginia); Christopher B. Arena (Blacksburg, Virginia); Michael B. Sano (Albany, New York) |
| ABSTRACT | Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. |
| FILED | Thursday, January 04, 2024 |
| APPL NO | 18/404473 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0538 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277847 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Jewett (Tucson, Arizona); Garrett J. Davis (Tucson, Arizona) |
| ABSTRACT | Triazenes and methods of producing diazonium species from said traizenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. Thus, the present invention also includes triazenes for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 18/566935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0042 (20130101) Original (OR) Class A61K 47/545 (20170801) A61K 49/0052 (20130101) A61K 49/0056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277854 | Blake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. Blake (Stanford, California); Paul Wender (Stanford, California); Robert Waymouth (Stanford, California); Ronald Levy (Stanford, California); Ole Haabeth (Stanford, California); Rebecca Mcclellan (Stanford, California); Adrienne Sallets (Stanford, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 47/549 (20170801) A61K 47/593 (20170801) Original (OR) Class A61K 48/0041 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) C08G 63/64 (20130101) C08G 63/685 (20130101) C08G 73/028 (20130101) C08G 73/0293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277870 | Waymouth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M Waymouth (Palo Alto, California); Paul Wender (Palo Alto, California); Jessica R. Vargas (Palo Alto, California); Tim R. Blake (Palo Alto, California); Colin J. McKinlay (Palo Alto, California); Ronald Levy (Palo Alto, California); Ole Audun Werner Haabeth (Palo Alto, California); Nancy Benner (Palo Alto, California); Katherine Near (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Tuesday, March 12, 2024 |
| APPL NO | 18/602410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) A61K 47/6883 (20170801) A61K 47/6907 (20170801) A61K 47/6931 (20170801) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/88 (20130101) C12N 15/115 (20130101) C12N 15/1135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277903 | Almarza et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Alejandro Almarza (Pittsburgh, Pennsylvania); Adam Chin (Pembroke Pines, Florida); Juan Toboas (Pittsburgh, Pennsylvania); Yadong Wang (Ithaca, New York) |
| ABSTRACT | The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639302 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/56 (20130101) A61L 27/446 (20130101) Original (OR) Class A61L 27/3817 (20130101) A61L 2430/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278056 | Pinkard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AQUAGGA, INC. (Tacoma, Washington) |
| ASSIGNEE(S) | AQUAGGA, INC. (Tacoma, Washington) |
| INVENTOR(S) | Brian Pinkard (University Place, Washington); Mike Czerski (Seattle, Washington); Alex De Marne (Mountlake Terrace, Washington); Joshua MacEachern (Tualatin, Oregon) |
| ABSTRACT | A system for breaking down a PFA (perfluoroalkyl or polyfluoroalkyl) compound includes a reactor vessel, a heater, and a catalyst. The reactor vessel is operable to hold influent that includes a PFA compound, an alkali, and water, while alkaline hydrolysis separates a fluorine atom from the PFA compound in the influent. The heater is operable to heat the influent to a temperature within the range of 100° Celsius to 700° Celsius. And the catalyst is operable to increase the rate at which alkaline hydrolysis separates a fluorine atom from a PFA compound. The catalyst includes a body that includes a transition metal, which is a d-block metal or a metal from any of the periodic table's groups 4-11. The body also has a shape configured to multiply a surface-area-to-volume ratio by at least 1.5 when the body is disposed in an influent experiencing alkaline hydrolysis. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/568852 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/34 (20130101) Original (OR) Class A62D 3/35 (20130101) A62D 3/36 (20130101) A62D 3/40 (20130101) A62D 2101/22 (20130101) A62D 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278241 | Tse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CytoVale Inc. (San Francisco, California) |
| ASSIGNEE(S) | CytoVale Inc. (San Francisco, California) |
| INVENTOR(S) | Henry Tat Kwong Tse (San Francisco, California); Ajay M. Shah (San Francisco, California); Lionel Guillou (San Francisco, California); Roya Sheybani (San Francisco, California); Christopher Dahlberg (San Francisco, California); Anne E. Jensen (San Francisco, California) |
| ABSTRACT | A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/637954 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0684 (20130101) B01L 2200/0694 (20130101) B01L 2300/185 (20130101) B01L 2300/0877 (20130101) B01L 2300/0887 (20130101) B01L 2400/0409 (20130101) B01L 2400/0415 (20130101) B01L 2400/0436 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30024 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278421 | CHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Austin, Texas); Forrest GREEN (Austin, Texas); Peter WORSNOP (Bethesda, Maryland); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495633 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278423 | Ciocarlie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matei Ciocarlie (New York, New York); Gagan Khandate (New York, New York); Maximilian Haas-Heger (New York, New York) |
| ABSTRACT | A system for generating a model-free reinforcement learning policy for a robotic hand for grasping an object is provided, including a processor; a memory; and a simulator implemented via the processor and the memory, performing: sampling a plurality of stable grasps relevant to reorienting the grasped object about a desired axis of rotation and using stable grasps as initial states for collecting training trajectories; learning finger-gaiting and finger-grasping policies for each axis of rotation in the hand coordinate frame based on proprioceptive sensing in the robotic hand, wherein the finger-gaiting and finger-pivoting policy is implemented on the robotic hand. |
| FILED | Friday, March 22, 2024 |
| APPL NO | 18/613576 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 9/1612 (20130101) B25J 9/1671 (20130101) B25J 15/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278791 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Sun (Columbus, Ohio); Kannan Srinivasan (Columbus, Ohio) |
| ABSTRACT | Embodiments of the present disclosure a privacy-preserving defensive driving system that can detect abnormal following vehicles during driving. An example system may be configured to: continuously capture video data of the camera's field-of-view, detect following vehicles in the captured video data, and determine whether one or more following vehicles is exhibiting abnormal following behavior with respect to a first vehicle. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583068 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/16 (20130101) B60W 40/09 (20130101) Original (OR) Class B60W 50/14 (20130101) B60W 2050/0056 (20130101) B60W 2050/143 (20130101) B60W 2050/146 (20130101) B60W 2420/403 (20130101) B60W 2554/802 (20200201) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 20/58 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279098 | SAMBROTTO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Raymond SAMBROTTO (Blauvelt, New York) |
| ABSTRACT | Systems and methods for performing bioremediation using the Geobacillus sp. bacterial strain are provided which are capable of effectively degrading 1,4-dioxane and/or per- and polyfluoroalkyl substances (PFAS) and/or BaP and efficiently degrading other ring-based organic contaminants. The exemplary bioremediation methods include steps for administering an effective, degrading amount of the bacteria to soil containing excess amounts of 1,4-dioxane and/or PFAS and/or BaP and incubating the bacteria administered to the soil at a given temperature and for a duration that are suitable for promoting incubation and reducing and the concentration of 1,4-dioxane and/or PFAS and/or BaP below a maximum concentration, as might be specified by a regulatory body. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640659 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/10 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/07 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279232 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander E. Arnold (Milwaukee, Wisconsin); Douglas C. Stafford (Stoughton, Wisconsin); James M. Cook (Milwaukee, Wisconsin); Amanda N. Nieman (Hartford, Wisconsin); Michael Ming-Jin Poe (Fitchberg, Wisconsin); Guanguan Li (Shenzhen, Guangdong Province, China PRC) |
| ABSTRACT | Substituted 5-(4-methyl-6-phenyl-4H-benzo[f]imidazo[1,5-a][1.4]diazepin-3-yl)-1.2.4-oxadiazole compounds are ligands for the k opioid receptor and inhibit inducible nitric oxide synthase. The compounds have utility to inhibit NO production and treat associated inflammatory conditions. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 18/567191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5517 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279264 | NIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Jia NIU (Lexington, Massachusetts); Lianqian WU (Brington, Massachusetts) |
| ABSTRACT | Methods for controlled synthesis and chemical recycling of stereoregular polysaccharides via polymerization of biomass-derived anhydrosugars are provided. The anhydrosugars react with an initiator in the presence of a synergy of a catalyst and the initiator providing the polysaccharides with high chain end fidelity and an excellent molecular weight distribution in a controlled manner, which allows for the preparation of polymeric systems with well-defined architectures. The polysaccharides obtained by such methods can be substantially converted to the start monomers in the present of a catalyst and can be used for biomedicine. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/616904 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 3/10 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/10 (20130101) C08J 2305/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240279285 — Rippled Antiparallel Cross-Beta Dimers and Related Materials, Compositions and Methods
| US 20240279285 | Raskatov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jevgenij A. Raskatov (Santa Cruz, California) |
| ABSTRACT | Provided are rippled antiparallel cross-β dimers. In some embodiments, the dimers comprise (L,L,L)-(FX1F)k dimerized with (D,D,D)-(FX2F)k, where X1 and X2 are independently selected from any amino acid, and wherein k is an integer of 1 or greater. Also provided are rippled β-sheet fibrils comprising a plurality of the rippled antiparallel cross-β dimers of the present disclosure. Materials comprising the rippled antiparallel cross-β dimers and rippled β-sheet fibrils of the present disclosure are also provided, as are compositions comprising such materials. Also provided are methods of making the rippled antiparallel cross-β dimers and rippled β-sheet fibrils of the present disclosure. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570390 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279313 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michelle Lee (Santa Barbara, California); Wujing Xian (Los Angeles, California); Nathan W. Schmidt (Santa Monica, California); Gerard C. L. Wong (Los Angeles, California) |
| ABSTRACT | The invention disclosed herein comprises peptides designed to include an amino acid sequence that confers such peptides with an ability to induce positive Gaussian curvature (and/or an ability to inhibit negative Gaussian curvature) in mammalian cell membranes. The invention disclosed herein further includes methods of using such peptides, for example as a non-hormonal contraceptive, an antiviral agent, an anti-inflammatory agent, or a therapeutic agent which can, for example, reduce neurotransmitter or hormone secretion in order to treat neuropsychiatric or endocrine disorders. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 18/292207 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/775 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279413 | BAE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Chulsung BAE (Cohoes, New York) |
| ABSTRACT | The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/641651 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/04 (20130101) C08F 8/06 (20130101) C08F 8/36 (20130101) C08F 36/06 (20130101) C08F 36/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 25/08 (20130101) C08L 53/025 (20130101) C08L 65/02 (20130101) C08L 71/12 (20130101) C08L 81/06 (20130101) C08L 2312/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1023 (20130101) H01M 8/1072 (20130101) H01M 8/1088 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279551 | Abbott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas L. Abbott (Lansing, New York); Sangchul Roh (Ithaca, New York) |
| ABSTRACT | Compositions comprising liquid crystal composition(s) and isotropic liquid composition(s), and optionally, one or more salt(s) and methods of using same. In various examples, a composition is a bistable liquid crystalline emulsion. In various examples, a composition exhibits reversible emulsification and/or demulsification when subjected to an electric field. An optical device can comprise the composition(s). In various examples, device is an optical device, such as, for example, a light shutter, which may be a bistable light shutter or the like, a display, a television, a sensor, a window, which may be a smart window, an energy efficient window, a privacy window, or the like, a smart label, an electronic paper, an electrooptical device, or the like. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/568233 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/542 (20130101) Original (OR) Class C09K 2323/061 (20200801) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1391 (20130101) G02F 1/13743 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279638 | Minden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Impact Proteomics (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Minden (Pittsburgh, Pennsylvania); Stephanie Biedka (Pittsburgh, Pennsylvania) |
| ABSTRACT | Materials and methods for purifying DNA, RNA, and protein from a single sample are provided. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/438664 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6427 (20130101) C12N 15/101 (20130101) Original (OR) Class C12N 15/1013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279675 | Simon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of California (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of California (College Park, California) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Jingyuan Liu (College Park, Maryland); Georgios Vidalakis (Riverside, California); Sohrab Bodaghi (Laguna Niguel, California) |
| ABSTRACT | The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of systemic and phloem-limited movement and replication within the host plant. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/775822 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279719 | Ganguli |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Anurup Ganguli (Urbana, Illinois) |
| ABSTRACT | Provided herein are compositions and methods that rapidly detect a target nucleic acid molecule using a CRISPR or a CRISPR Cascade mechanism where binding of a target nucleic acid molecule initiates an amplification cascade by converting high KD guide RNA molecules to low KD guide RNA molecules. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570745 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) C12Q 1/6823 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280457 | Tabib-Azar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Massood Tabib-Azar (Salt Lake City, Utah) |
| ABSTRACT | Technology is disclosed related to devices, systems. and methods for detecting a target particle. The device can include a field generator source which emits an incident electromagnetic field: a resonator having a focusing structure to focus the incident electromagnetic field in a gap region that accepts the target particle; and a receiver to detect a resonant signal from the resonator, where the resonant signal shifts due to presence of the target particle in the gap region. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/569195 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2205 (20130101) G01N 15/02 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280535 | Ham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donhee Ham (Cambridge, Massachusetts); Woo-Bin Jung (Cambridge, Massachusetts); Han Sae Jung (Cambridge, Massachusetts); Jun Wang (Cambridge, Massachusetts); Young-Ha Hwang (Cambridge, Massachusetts); Henry Julian Hinton (Cambridge, Massachusetts); Jeffrey T. Abbott (Cambridge, Massachusetts); Hongkun Park (Cambridge, Massachusetts) |
| ABSTRACT | Devices and methods for controlling the local pH of solutions (e.g., for parallelized polymer synthesis) are generally described. These may offer several advantages, including the ability to control pH using a plurality of pixels, and/or the ability to sense the pH associated with each pixel, according to certain embodiments. In some embodiments, such devices are used to selectively synthesize polymer sequences (e.g., DNA sequences) associated with each pixel. The pixels can, in some embodiments, comprise electrodes that can apply an electrical potential or current to a solution comprising an electrically sensitive pH modifier. In some cases, reaction of the electrically sensitive pH modifier may cause a change in pH. The pixels may comprise circuit components that can operate in multiple modes (e.g. as potentiostats, galvanostats, or open-circuit potential sensors capable of sensing local pH). |
| FILED | Monday, June 13, 2022 |
| APPL NO | 18/569809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/27 (20130101) G01N 27/302 (20130101) G01N 27/4167 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280571 | Layouni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rabeb Layouni (Nashville, Tennessee); Paul E. Laibinis (Nashville, Tennessee); Sharon M. Weiss (Nashville, Tennessee) |
| ABSTRACT | The present disclosure provides for porous membrane sensors, methods of making porous membrane sensors, methods of using porous membrane sensors, and the like. The present disclosure provides for reliable rapid diagnostic tests (RDT) that are low-cost, are widely deployable, are highly sensitive, and can provide results quickly. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422496 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 33/54386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280665 | McDaniel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay W. McDaniel (Norman, Oklahoma); Justin G. Metcalf (Norman, Oklahoma); Rachel E. Jarvis (Norman, Oklahoma) |
| ABSTRACT | A method comprising: obtaining I/Q data associated with a received radar signal; performing background subtraction on the I/Q data to obtain a subtracted signal; applying an algorithm to the subtracted signal to obtain a filtered signal, wherein the algorithm is based on a MSE filter; performing time-gating on the filtered signal to obtain a time-gated signal; applying a FFT to convert the time-gated signal to a frequency-domain signal; and applying a calibration set to the frequency-domain signal to extract an RCS of an OUT; and a system for conducting the method. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/694705 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/32 (20130101) G01S 7/292 (20130101) Original (OR) Class G01S 7/411 (20130101) G01S 13/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280682 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weite Zhang (Malden, Massachusetts); Jose Angel Martinez-Lorenzo (Wellesley, Massachusetts) |
| ABSTRACT | A multiple-input-multiple-output (MIMO) radar system comprises two or more software-defined millimeter-wave (SDMMW) nodes, a host processing system that is electrically coupled to the two or more SDMMW nodes, and a MIMO aperture array coupled to the two or more SDMMW nodes. The MIMO radar system is configured to form a MIMO TX channel and a MIMO RX channel for each of the two or more SDMMW nodes. The MIMO radar system includes a millimeter wave (MMW) frequency-modulated continuous wave (FMCW) oscillator source configured to generate a MMW FMCW signal. For each of the two or more SDMMW nodes, the radar system includes an upconverter assembly and a downconverter assembly. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/569505 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/48 (20130101) Original (OR) Class G01S 13/89 (20130101) Transmission H04B 1/0003 (20130101) H04B 7/0413 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280712 | Aspinwall et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of The University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Aspinwall (Tucson, Arizona); Chen-Yi Ke (Tucson, Arizona); Minhui Han (Tucson, Arizona); Brian Zacher (Tucson, Arizona) |
| ABSTRACT | Described herein are metal organic framework (MOF) particles and methods for detecting and quantifying radioisotopes with such MOF particles, where detecting and quantifying such radioisotopes can occur in a solvent. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/642605 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) G01T 1/2012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281582 | BARKER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating timing libraries. The apparatus includes a memory and a processor. The processor determines a condition that indicates whether a superconducting electronic circuit design passes or fails logic verification and determines an edge-of-failure value for a timing parameter for the superconducting electronic circuit design. The processor simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a first process variation to produce a first timing value for the superconducting electronic circuit design and simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a second process variation to produce a second timing value for the superconducting electronic circuit design. The processor generates a timing library for the superconducting electronic circuit design based at least in part on the first timing value and the second timing value. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/110932 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3315 (20200101) Original (OR) Class G06F 2111/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281695 | Mashhad et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico); Alphabet Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milad Marvian Mashhad (Albuquerque, New Mexico); Ivan Deutsch (Albuquerque, New Mexico); Sivaprasad Omanakuttan (Albuquerque, New Mexico); Sri Datta Vikas Buchemmavari (Albuquerque, New Mexico); Jonathan A. Gross (Albuquerque, New Mexico) |
| ABSTRACT | A set of quantum error correcting codes for spin systems providing a path to fault tolerance with fewer qubits by using the extra available internal degrees of freedom. Cat codes in the spin system are used which are the equal superpositions of stretched states, with consideration of errors that are products of angular momentum and not just restricted to linear in angular momentum operators. |
| FILED | Wednesday, February 14, 2024 |
| APPL NO | 18/441924 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281940 | Zhou et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Zhou (Durham, North Carolina); Ryan McNabb (Durham, North Carolina); Ruobing Qian (Durham, North Carolina); Al-Hafeez Dhalla (Durham, North Carolina); Sina Farsiu (Durham, North Carolina); Joseph Izatt (Durham, North Carolina) |
| ABSTRACT | A method of performing computational image contrast from multidimensional data includes receiving a plurality of images of an object, with each image of the plurality of images having more than three dimensions, performing multi-dimensional registration of the plurality of images to generate a multi-dimensional dataspace, reducing dimensionality of the multi-dimensional dataspace to create an enhanced resolution and contrast image of a 3D space of the object using the plurality of images as registered in the multi-dimensional dataspace, and displaying the enhanced resolution and contrast image. In some cases, reducing the dimensionality of the multi-dimensional dataspace to create the enhanced resolution and contrast image of the 3D space of the object comprises utilizing at least one of variance, high-order statistics, entropy, principal component analysis, t-distributed stochastic neighborhood embedding, and neural networks using the plurality of images as registered in the multi-dimensional dataspace. |
| FILED | Monday, February 19, 2024 |
| APPL NO | 18/581157 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4053 (20130101) G06T 5/90 (20240101) Original (OR) Class G06T 7/30 (20170101) G06T 2207/10101 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282460 | Balaji et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Janani Balaji (San Antonio, Texas); Jennifer Brethen (San Antonio, Texas); George Britton (San Antonio, Texas); Nicolas Grandel (San Antonio, Texas); Chenyue Hu (San Antonio, Texas); Zaharie Maloney (San Antonio, Texas); Sean Tritley (San Antonio, Texas); Byron Long (San Antonio, Texas); Arun Mahadevan (San Antonio, Texas); Erin Pollet (San Antonio, Texas); Amina Ann Qutub (San Antonio, Texas) |
| ABSTRACT | Methods described herein are directed to solving the problem of safely evaluating organs or tissues in a living subject and assessing and monitoring these living systems. In certain aspects the brain of a living subject is evaluated. The methods described herein integrate behavioral measurements and other non-invasive information gathering (e.g., imaging, EEG, etc.) or minimally invasive information gathering (e.g., biological fluid sampling) with cellular imaging, and biomimetic models to safely evaluate a subject. In vitro models are established that can be manipulated and monitored on the cellular level. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570151 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/369 (20210101) A61B 5/4806 (20130101) A61B 5/6802 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282913 | MENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ENTEGRIS, INC. (Billerica, Massachusetts) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Xiangbo MENG (Fayetteville, Arkansas); Xin WANG (Fayetteville, Arkansas) |
| ABSTRACT | The invention provides improved slurries for the polishing of hard materials such as those having a Mohs hardness of greater than about 6. Exemplary hard surfaces include sapphire, silicon carbide, silicon nitride, and gallium nitride, and diamond. In the compositions and method of the invention, novel compositions comprising a unique combination of additives which surprisingly were found to uniformly disperse diamond particles having a wide range of particle size in a slurry. In the method of the invention, the generally alkaline slurry compositions of the invention are capable of utilizing diamond particle sizes of greater than 40 microns while effecting good removal rates. In such cases, when utilized with a suitable pad, rapid and planar grinding of silicon carbide, silicon nitride, sapphire, gallium nitride, and diamond is possible, with uniform surface damage. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570618 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282941 | Koenig, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary M. Koenig, JR. (Fishersville, Virginia); Cai Chen (Chartottesville, Virginia) |
| ABSTRACT | According to various aspects, an electrochemical storage device includes a sintered electrode. The sintered electrode includes a doped LiMn2O4. The doped LiMn2O4 comprises at least 95 wt % of the sintered electrode. Alternatively or in combination, the sintered electrode can include a coated LiMn2O4 substrate. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 18/684122 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282947 | BANERJEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (COLLEGE STATION, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SARBAJIT BANERJEE (COLLEGE STATION, Texas); JUSTIN L. ANDREWS (COLLEGE STATION, Texas) |
| ABSTRACT | A highly scalable process has been developed for stabilizing large quantities of the zeta-polymorph of V2O5, a metastable kinetically trapped phase, with high compositional and phase purity. The process utilizes a beta-Cux V2O5 precursor which is synthetized from solution using all-soluble precursors. The copper can be leached from this structure by a room temperature post-synthetic route to stabilize an empty tunnel framework entirely devoid of intercalating cations. The metastable ζ-V2O5 thus stabilized can be used as a monovalent-(Li, Na) or multivalent-(Mg, Ca, Al) ion battery cathode material. |
| FILED | Monday, January 08, 2024 |
| APPL NO | 18/406264 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 31/02 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/77 (20130101) C01P 2002/78 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/16 (20130101) C01P 2006/40 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 15/0065 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/485 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282989 | Sitaula et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paban Sitaula (Morrisville, North Carolina); Susan A. Odom (Lexington, Kentucky) |
| ABSTRACT | The presently-disclosed subject includes permanent-charge-bearing phenothiazinc derivatives that are redox-active, have beneficial solubility, and do not require supporting salts when used in redox flow battery applications. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442752 |
| CURRENT CPC | Heterocyclic Compounds C07D 279/26 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/04186 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240284042 | Angizi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey); Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey); Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Shaahin Angizi (Newark, New Jersey); Arman Roohi (Lincoln, Nebraska) |
| ABSTRACT | Disclosed is a Processing-In-Sensor Accelerator (PISA) that provides a flexible, energy-efficient, and high-performance solution for real-time and smart image processing in AI devices. PISA implements a coarse-grained convolution operation in Binarized-Weight Neural Networks (BWNNs) leveraging a novel compute-pixel with non-volatile weight storage at the sensor side. This reduces power consumption of data conversion and transmission to an off-chip processor. A bit-wise near-sensor in-memory computing unit processes the remaining network layers. Once the object is detected, PISA switches to typical sensing mode to capture the image for a fine-grained convolution using only a near-sensor processing unit. The circuit-to-application co-simulation results on a BWNN acceleration demonstrate minor accuracy degradation on various image datasets in coarse-grained evaluation compared to baseline BWNN models. PISA achieves a frame rate of 1000 and efficiency of 1.74 TOp/s/W. PISA reduces data conversion and transmission energy by at least 84% compared to a baseline. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/439267 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/75 (20220101) G06V 10/82 (20220101) Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 20/10 (20200101) G16Y 40/35 (20200101) Pictorial Communication, e.g Television H04N 23/61 (20230101) H04N 23/651 (20230101) Original (OR) Class H04N 23/667 (20230101) H04N 25/42 (20230101) H04N 25/709 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240276985 | Piotrowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Jeff S. Piotrowski (Madison, Wisconsin); Fachuang Lu (Madison, Wisconsin); Mehdi Kabbage (Sun Prairie, Wisconsin); John Ralph (Madison, Wisconsin); Robert C. Landick (Madison, Wisconsin) |
| ABSTRACT | Antimicrobial diferulates, compositions containing same, and uses of same for inhibiting growth of microorganisms. The antimicrobial diferulates can be used alone or in combination with other antimicrobial agents to inhibit growth of microorganisms such as fungi, oomycetes, and other microorganisms having a glucan-containing cell wall. The antimicrobial diferulates can be included in pharmaceutical compositions for treatment of animals or included in agricultural compositions for treatment of plants, crops, and soils. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639647 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/38 (20130101) Original (OR) Class A01N 43/08 (20130101) A01N 43/12 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/343 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277854 | Blake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. Blake (Stanford, California); Paul Wender (Stanford, California); Robert Waymouth (Stanford, California); Ronald Levy (Stanford, California); Ole Haabeth (Stanford, California); Rebecca Mcclellan (Stanford, California); Adrienne Sallets (Stanford, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 47/549 (20170801) A61K 47/593 (20170801) Original (OR) Class A61K 48/0041 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) C08G 63/64 (20130101) C08G 63/685 (20130101) C08G 73/028 (20130101) C08G 73/0293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277870 | Waymouth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M Waymouth (Palo Alto, California); Paul Wender (Palo Alto, California); Jessica R. Vargas (Palo Alto, California); Tim R. Blake (Palo Alto, California); Colin J. McKinlay (Palo Alto, California); Ronald Levy (Palo Alto, California); Ole Audun Werner Haabeth (Palo Alto, California); Nancy Benner (Palo Alto, California); Katherine Near (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Tuesday, March 12, 2024 |
| APPL NO | 18/602410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) A61K 47/6883 (20170801) A61K 47/6907 (20170801) A61K 47/6931 (20170801) A61K 48/0041 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/88 (20130101) C12N 15/115 (20130101) C12N 15/1135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278492 | CERÓN HERNÁNDEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Maira R. CERÓN HERNÁNDEZ (Brentwood, California); Hannah V. ESHELMAN (Pleasanton, California); Jennifer Marie KNIPE (Oakland, California); Alexandra E.L. OVERLAND (Livermore, California); Michael J. TROKSA (Pleasanton, California); Joshua R. DEOTTE (San Ramon, California); Du T. NGUYEN (Castro Valley, California) |
| ABSTRACT | The present disclosure relates to a system for additively manufacturing a structure for transporting carbon dioxide. The system makes use of a nozzle component having a housing. The housing has a first nozzle for receiving a powder capable of capturing carbon dioxide, and channeling the powder through the nozzle component. The housing also has a second nozzle configured to receive a polymer component and to channel the polymer through the housing without intermixing of the polymer and the powder. A print head is in communication with the housing and configured to receive both the powder and the polymer, and to co-extrude the powder and the polymer so that the polymer forms a shell that encases the powder as the powder and polymer are co-extruded. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/385791 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/18 (20210101) B22F 12/53 (20210101) B22F 12/224 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/165 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/236 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278499 | LEWICKI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James LEWICKI (Oakland, California) |
| ABSTRACT | Systems for manufacturing a Stage 1 carbon-carbon (CC) part, including a resin infused with at least one of chopped fibers, milled fibers, or a continuous fiber. The resin further may include at least one UV initiator to render the resin UV gellable upon exposure to UV light. An additive manufacturing (AM) system determines and provides tool paths needed to provide an engineered characteristic to the Stage 1 CC part. A print nozzle component of the AM system extrudes the resin in accordance with the tool paths onto a sacrificial support material layer, such that the fiber(s) are deposited in desired orientations, within each layer, in a layer-by-layer printing operation. A UV light illuminates the resin after extrusion to initiate gelation of the resin as the resin is extruded onto the sacrificial material layer, to thus form a precursor part having an imparted or enhanced performance characteristic. A pyrolysis subsystem may be used for pyrolyzing the precursor part to create the Stage 1 CC part. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111452 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) Original (OR) Class B29C 64/118 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/83 (20130101) C04B 35/624 (20130101) C04B 35/6269 (20130101) C04B 2235/48 (20130101) C04B 2235/422 (20130101) C04B 2235/5248 (20130101) C04B 2235/6026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278507 | LEWICKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livemore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James LEWICKI (Oakland, California); Nicholas Hanson LOEY (Livermore, California) |
| ABSTRACT | The present disclosure relates to an additive manufacturing (AM) system for making a part. The system may have a build plate on which to form the part, and a print nozzle component configured to be supported above the build plate. The print nozzle may have a first and second axially extending passageways. The first axially extending passageway enables a first resin-infused feedstock material supplied from a first source of resin-infused feedstock material to be extruded onto the build plate. The second axially extending passageway enables a second resin-infused feedstock material supplied from a second source of resin-infused feedstock material to be extruded onto the build plate concurrently with, or alternately with, extrusion of the first resin-infused feedstock material, to form the part. The first and second resin-infused print feedstock materials differ in composition from one another. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111447 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/40 (20170801) Original (OR) Class B29C 64/135 (20170801) B29C 64/209 (20170801) B29C 64/245 (20170801) B29C 2791/002 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2101/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240278704 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Terabase Energy, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Campbell (Berkeley, California); Brian Coleman (Portland, Oregon); Tianyu Zhao (Pacifica, California); Adam Hansel (Davis, California); Soren Jensen (Corte Madera, California) |
| ABSTRACT | A solar table mobile transport is described that moves a solar table to a point of installation. The solar table mobile transport comprises multiple motors that allow movement within a three-dimensional coordinate system as well as provide angular controls of pitch, yaw and roll. These motors enable at least one alignment process used to install the solar table to a mounting structure within a solar system. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/616154 |
| CURRENT CPC | Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 3/00 (20130101) Original (OR) Class Solar Heat Collectors; Solar Heat Systems F24S 25/30 (20180501) F24S 25/65 (20180501) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 99/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279109 | TOPPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Brian TOPPER (Albuquerque, New Mexico); Arash MAFI (Albuquerque, New Mexico); Johann Richard WEBER (Arlington Heights, Illinois); Stephen Kenneth WILKE (Evanston, Illinois) |
| ABSTRACT | According to examples of the present disclosure, a glass product is disclosed that includes a composition of which comprises at least 50 molar percent titanium dioxide and at least 0.1 molar percent rare earth metal oxide wherein the rare earth is at least one of the following elements: scandium, yttrium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443686 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 3/127 (20130101) Original (OR) Class C03C 4/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279127 | Petrie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian M. Petrie (Oak Ridge, Tennessee); Brian C. Jolly (Oak Ridge, Tennessee); Kurt A. Terrani (Oak Ridge, Tennessee); Michael P. Trammell (Oak Ridge, Tennessee) |
| ABSTRACT | An improved method for embedding one or more sensors in SiC is provided. The method includes depositing a binder onto successive layers of a SiC powder feedstock to produce a dimensionally stable green body have a true-sized cavity. A sensor component is then press-fit into the true-sized cavity. Alternatively, the green body is printed around the sensor component. The assembly (the green body and the sensor component) is heated within a chemical vapor infiltration (CVI) chamber for debinding, and a precursor gas is introduced for densifying the SiC matrix material. During infiltration, the sensor component becomes bonded to the densified SiC matrix, the sensor component being selected to be thermodynamically compatible with CVI byproducts at elevated temperatures, including temperatures in excess of 1000° C. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640294 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/63 (20130101) C04B 35/565 (20130101) C04B 37/021 (20130101) Original (OR) Class C04B 37/042 (20130101) C04B 2235/3826 (20130101) C04B 2235/6026 (20130101) C04B 2237/62 (20130101) C04B 2237/365 (20130101) C04B 2237/403 (20130101) C04B 2237/408 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 11/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279413 | BAE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Chulsung BAE (Cohoes, New York) |
| ABSTRACT | The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer. The swellable functional groups are selectively connected to the soft domains of the block copolymers, so that when the membrane swells (under hydration or gas adsorption), the stress is effectively absorbed by the soft domain and the impact on overall mechanical properties is minor, resulting in more durable membranes. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/641651 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/04 (20130101) C08F 8/06 (20130101) C08F 8/36 (20130101) C08F 36/06 (20130101) C08F 36/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 25/08 (20130101) C08L 53/025 (20130101) C08L 65/02 (20130101) C08L 71/12 (20130101) C08L 81/06 (20130101) C08L 2312/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1023 (20130101) H01M 8/1072 (20130101) H01M 8/1088 (20130101) H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279467 | Lewicki |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Lewicki (Oakland, California) |
| ABSTRACT | A composition of a resin for room temperature vulcanizable rubber includes a polysiloxane with vinyl and/or silanol reactive functionality of at least 2, a crosslinker reactive toward vinyl and/or silanol functionality, polymer microballoons, and a thixotropic additive. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111397 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/08 (20130101) C08G 77/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/228 (20130101) C08J 2203/22 (20130101) C08J 2383/07 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class C08L 2312/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279526 | WARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PATRICK A. WARD (AIKEN, South Carolina); RAGAIY ZIDAN (AIKEN, South Carolina) |
| ABSTRACT | Disclosed are high enthalpy thermochemical energy storage materials that exhibit high thermal conductivity and stability at high temperature reaction conditions. Disclosed materials include hydride-based alloys that can undergo high temperature reversible hydrogenation/dehydrogenation reactions without phase change of any metal or metalloid components of the alloy. The materials undergo a reversible exothermic hydrogenation reaction to form a metal hydride and a ternary alloy that includes a high thermal conductivity metal that, in its pure state, would exhibit a phase change at the hydrogenation reaction conditions. |
| FILED | Thursday, April 04, 2024 |
| APPL NO | 18/626405 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Original (OR) Class Alloys C22C 1/10 (20130101) C22C 24/00 (20130101) Collection, Production or Use of Heat Not Otherwise Provided for F24V 30/00 (20180501) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279551 | Abbott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas L. Abbott (Lansing, New York); Sangchul Roh (Ithaca, New York) |
| ABSTRACT | Compositions comprising liquid crystal composition(s) and isotropic liquid composition(s), and optionally, one or more salt(s) and methods of using same. In various examples, a composition is a bistable liquid crystalline emulsion. In various examples, a composition exhibits reversible emulsification and/or demulsification when subjected to an electric field. An optical device can comprise the composition(s). In various examples, device is an optical device, such as, for example, a light shutter, which may be a bistable light shutter or the like, a display, a television, a sensor, a window, which may be a smart window, an energy efficient window, a privacy window, or the like, a smart label, an electronic paper, an electrooptical device, or the like. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/568233 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/542 (20130101) Original (OR) Class C09K 2323/061 (20200801) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/1391 (20130101) G02F 1/13743 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279768 | ZIEMKIEWICZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul ZIEMKIEWICZ (Morgantown, West Virginia); Aaron NOBLE (Blacksburg, West Virginia); Chris VASS (Rainelle, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to a continuous process for treating acid mine drainage while simultaneously recovering a high-grade rare earth preconcentrate suitable for extraction of commercially valuable rare earth oxides. In a further aspect, the preconcentrate is from about 0.1% to 5% rare earth elements on a dry weight basis. In another aspect, the disclosure relates to a method for processing the preconcentrate to generate a pregnant leach solution that does not form gels or emulsions and is suitable for processing via solvent extraction. In another aspect, the disclosure relates to a system and plant for carrying out the disclosed process. In still another aspect, the disclosure relates to a composition containing rare earth elements produced by the process disclosed herein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Friday, March 08, 2024 |
| APPL NO | 18/600497 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/20 (20130101) C22B 3/065 (20130101) Original (OR) Class C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279774 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Mcfarland Park (Dublin, California); Gauthier Deblonde (San Ramon, California); Ziye Dong (Dublin, California); Yongqin Jiao (Pleasanton, California); Joseph Anthony Mattocks (University Park, Pennsylvania); Joseph Alfred Cotruvo, Jr. (University Park, Pennsylvania) |
| ABSTRACT | Methods and materials are provided for the preferential separation of rare earth elements (REEs) from non-REEs in REE-containing materials and separation of certain REEs from other REEs, both individually and in groups. Such methods include steps of (a) providing a protein that can selectively bind one or more REEs; (b) contacting the protein with the REE-containing material, wherein the protein binds at least a portion of the one or more REEs to form one or more protein-REE complexes and an REE-depleted material; (c) separating the one or more protein-REE complexes from at least a portion of the REE-depleted material; and (d) separating the one or more REEs from the protein to produce a purified fraction of the one or more REEs and a regenerated protein. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570543 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/10 (20130101) C22B 3/18 (20130101) C22B 3/165 (20130101) C22B 59/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280076 | MENDOZA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Renee MENDOZA (Longmont, Colorado); Nicholas Aaron JOHNSON (Golden, Colorado); Derek Stephen BERRY (Broomfield, Colorado) |
| ABSTRACT | Among other things, the present disclosure relates to a wind turbine rotor blade that can be assembled at the site of its wind turbine. The blade includes an internal structure which may be pre-fabricated with connections to the shell skin prior to being transported to the site of its wind turbine. A filler material may be injected into the layers of fabric making up the shell skin at the wind turbine site and allowed to harden at approximately atmospheric conditions. |
| FILED | Tuesday, April 16, 2024 |
| APPL NO | 18/636770 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/48 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/0025 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/085 (20130101) Wind Motors F03D 1/0675 (20130101) Original (OR) Class Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2230/20 (20130101) F05B 2230/90 (20130101) F05B 2280/6001 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240280480 | MALLERY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rebellion Photonics, Inc. (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan MALLERY (Houston, Texas); Ohad Israel BALILA (Friendswood, Texas); Robert Timothy KESTER (Friendswood, Texas) |
| ABSTRACT | An infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including a focal plane array (FPA) unit behind an optical window. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. One or more of the optical channels may be used in detecting objects on or near the optical window, to avoid false detections of said target species. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/649745 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/314 (20130101) G01N 21/3504 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281010 | KISHORE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravi Anant KISHORE (Lakewood, Colorado); Sampath KOMMANDUR (Golden, Colorado); Charles William BOOTEN (Arvada, Colorado); Lance Michael WHEELER (Wheat Ridge, Colorado); Shuang CUI (Dallas, Texas); Zhiying XIAO (Lakewood, Colorado) |
| ABSTRACT | The present disclosure relates to a directional heat transfer using thermal control devices, including a dual phase change thermal diode and an active contact-based thermal switch. The thermal diode includes a positive temperature coefficient switching material and a negative temperature coefficient switching material arranged in series. The thermal switch includes two thermally conducting surfaces which may be moved to contact (i.e., having a distance between them of substantially zero) creating minimal thermal contact resistance. Both thermal control devices may be used to control heat flow into and/or out of a building. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/648714 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 23/121 (20130101) Original (OR) Class Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 37/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281572 | Urick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | nVariate, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Urick (Roseville, California); Richard H. Crawford (Austin, Texas); Daniel L. Keller (Waitsfield, Vermont); Lisa A. Torres (Austin, Texas) |
| ABSTRACT | Methods and computer systems for methods, computer systems, and computer-readable memory media for determining a warp function. A first watertight spline model of a first object and a set of points and associated metadata from a second object are received. A second watertight spline model of the second object is constructed based on the set of points, the metadata, and the first watertight spline model. A warp function is determined based on a difference between the first watertight spline model and the second watertight spline model. The warp function is a continuous function approximating differences between the first object and the second object. The warp function is stored in a non-transitory computer-readable memory medium. |
| FILED | Thursday, April 11, 2024 |
| APPL NO | 18/632827 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/17 (20200101) Original (OR) Class Image Data Processing or Generation, in General G06T 17/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240281692 — TEMPORAL AND SFQ PULSE STREAM ENCODING FOR AREA EFFICIENT SUPERCONDUCTING ACCELERATORS
| US 20240281692 | Gonzalez-Guerrero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luisa Patricia Gonzalez-Guerrero (Naperville, Illinois); Georgios Michelogiannakis (Berkeley, California); Meriam Gay Bautista (Katy, Texas); Darren Lyles (San Ramon, California) |
| ABSTRACT | A superconducting computing architecture includes at least one computing element including a first input to receive a first set of electrical pulses encoded in a first data representation, a second input to receive a second set of electrical pulses encoded in a second data representation, and an operator to perform an operation and generate an output based on the first input and the second input. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583530 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282078 | KESSELI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devon James KESSELI (Boulder, Colorado); Rebecca Amelia MITCHELL (Denver, Colorado); Guangdong ZHU (Englewood, Colorado) |
| ABSTRACT | Non-invasively detecting or determining heliostat surface opto-mechanical errors (e.g., surface slope, canting, and/or tracking) is described. At least one image captured of a target reflected on a heliostat surface may be used to determine the heliostat error. This may be based on the distortion of the target reflected on the heliostat compared to the expected reflection of the target on the heliostat. Image processing and computer vision may be utilized to generate a surface slope map of the heliostat and determine the error compared to an “ideal” model of the heliostat. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/582175 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/44 (20220101) G06V 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282473 | Cheatham, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TerraPower, LLC (Bellevue, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse R. Cheatham, III (Seattle, Washington); Christopher M. Reagan (Seattle, Washington); John E. Truax (Bonney Lake, Washington); Jacob Wilcox (Arlington, Washington) |
| ABSTRACT | A failed fuel pin emits cesium into the primary sodium coolant and xenon into the cover gas in a reactor vessel. A pipe containing radioactive liquid sodium accepts flowing primary sodium from the reactor vessel. A radiation detector is positioned adjacent the pipe such that gamma radiation emitted from the pipe can be measured. The pipe may be isolated to increase detection limits by allowing short-lived isotopes to decay. The isotopic ratio of 137Cs/134Cs can be measured, which can be used to determine the burnup of a fuel assembly from within the core, and therefore, the failed fuel assembly can be identified based at least in part on the burnup. Further, mass spectrometry may be used to measure the ratio of a stable and unstable xenon isotope. The identification techniques may be used in conjunction to quickly identify a failed fuel assembly in-situ and during reactor operation. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/393377 |
| CURRENT CPC | Nuclear Reactors G21C 17/002 (20130101) G21C 17/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282488 | Raju |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ravisekhar Raju (Clifton Park, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravisekhar Raju (Clifton Park, New York) |
| ABSTRACT | An electrical insulating tube is provided which isolates at least one conductor placed within the tube and a second conductor or elements that are placed outside the tube. The tube comprises a first conductive coating or foil placed on the inner surface or within the insulating tube material but substantially near its inner surface with this first conductive coating or foil electrically referenced to the conductor placed within the tube. The tube optionally comprises a second conductive coating or foil placed on the outer surface or within the tube material but substantially near its outside surface with this second conductive coating or foil electrically referenced to a conductor or electrical element placed outside the tube. Several embodiments and methods to make the tube are described. |
| FILED | Tuesday, February 20, 2024 |
| APPL NO | 18/582643 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 17/58 (20130101) Original (OR) Class H01B 17/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282542 | Antoniuk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Antoniuk (Stanford, California); Bruce Dunham (Stanford, California); Piero Pianetta (Stanford, California); Theodore Vecchione (Stanford, California); Evan J. Reed (Stanford, California) |
| ABSTRACT | Among various examples, one is directed to identifying one or more particular photocathode semiconductor structures via a computer-based method. The method includes calculating, for each of a plurality of semiconductor materials and via a database characterizing electronic band structures of respective semiconductor materials corresponding to the plurality of semiconductor materials, an intrinsic emittance score (e.g., using an optimistic selection of a work function) as a predictive screening metric for whether the semiconductor material may exhibit low intrinsic emittance. A subset of the semiconductor materials may be selected, wherein each of the semiconductor materials in the subset satisfies screening criteria based on the intrinsic emittance score, and photocathode brightness properties of said one or more of the semiconductor materials in the subset are characterized, thereby identifying certain semiconductor materials in the subset of the semiconductor materials with desirable photocathode brightness properties. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570222 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/373 (20200101) G06F 2111/10 (20200101) G06F 2119/08 (20200101) G06F 2119/18 (20200101) Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) Original (OR) Class H01J 9/12 (20130101) H01J 2201/3423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282549 | Axelrod et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy J. Axelrod (Berkeley, California); Carter Turnbaugh (Berkeley, California); Sara Campbell (El Cerrito, California); Osip Schwartz (Albany, California); Robert M. Glaeser (Berkeley, California); Holger Mueller (Orinda, California) |
| ABSTRACT | A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first mirror and a second mirror that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light. |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/634129 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/22 (20130101) Original (OR) Class H01J 2237/2482 (20130101) H01J 2237/2614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282662 | Chowdhury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Md Shajjad Chowdhury (Knoxville, Tennessee); Emre Gurpinar (Knoxville, Tennessee); Burak Ozpineci (Knoxville, Tennessee) |
| ABSTRACT | A multilayer substrate for a power module is provided. The multilayer substrate may include a copper tile soldered between an integrated circuit component and a direct bonded copper assembly in order to facilitate heat dissipation from the integrated circuit component. |
| FILED | Thursday, September 28, 2023 |
| APPL NO | 18/374410 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3672 (20130101) H01L 23/3735 (20130101) Original (OR) Class H01L 24/32 (20130101) H01L 24/33 (20130101) H01L 25/072 (20130101) H01L 2224/32265 (20130101) H01L 2224/33505 (20130101) H01L 2924/1517 (20130101) H01L 2924/15747 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240283011 | Visco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Vitaliy Nimon (Berkeley, California); Yevgeniy S. Nimon (Berkeley, California); Bruce D. Katz (Berkeley, California) |
| ABSTRACT | A sulfide glass solid electrolyte sheet can be protected from reaction with moisture by a thin metal layer coating converted to a thin electrochemically functional and protective compound layer. The converted protective compound layer is electrochemically functional in that it allows for through transport of lithium ions. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529777 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 50/403 (20210101) H01M 50/437 (20210101) H01M 50/451 (20210101) H01M 50/457 (20210101) H01M 2300/0068 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240283280 | Varigonda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subbarao Varigonda (Columbus, Indiana); Jaroslaw Leonarski (Columbus, Indiana); Harsha R. Ademane (Indianapolis, Indiana) |
| ABSTRACT | A mild-hybrid energy storage system architecture is provided, comprising: a battery; an ultracapacitor connected in parallel with the battery; a passive battery pre-charge circuit connected between a terminal of the battery and a DC bus; a battery main contactor connected in parallel with the battery pre-charge circuit between the terminal of the battery and the DC bus; a passive ultracapacitor pre-charge circuit connected between a terminal of the ultracapacitor and the DC bus; an ultracapacitor main contactor connected in parallel with the ultracapacitor pre-charge circuit between the terminal of the ultracapacitor and the DC bus; and a control module configured to independently control operation of the battery pre-charge circuit, the battery main contactor, the ultracapacitor pre-charge circuit and the ultracapacitor main contactor. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589120 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/28 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/48 (20130101) H01M 10/0525 (20130101) H01M 2220/20 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/345 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240283378 | Moheimani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Omid Reza Moheimani (Allen, Texas); Afshin Alipour (Richardson, Texas); Mustafa Bulut Coskun (Pasadena, California) |
| ABSTRACT | A microelectromechanical (MEMS) device is provided. The MEMS device comprises a substrate and a movable structure flexurally connected to the substrate, capable of moving in relation to the substrate, wherein the movable structure further comprising two or more segments having at least one mechanical connection between said segments to provide structural integrity of the moving structure; and wherein the at least one mechanical connection electrically isolates at least two segments |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/633690 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/16 (20130101) Electric Machines Not Otherwise Provided for H02N 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240284586 | JIANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Omega-P R and D, Inc. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong JIANG (New Haven, Connecticut) |
| ABSTRACT | Apparatuses and methods for accelerating electrons include a radio-frequency (RF) waveguide configured to couple an RF source to an accelerator that utilizes electron cyclotron resonance acceleration (eCRA). The RF waveguide includes a pair of parallel rectangular waveguides including a first waveguide and a second waveguide and a mode converter coupled to respective ends of the pair of parallel rectangular waveguides. The mode converter includes and outer body and two coaxial cylinders. An electron source is configured to provide a beam of electrons through an inner cylinder. An accelerator includes a RF cavity having a longitudinal axis, a cylindrical outer wall, an inlet, and an outlet and an electro-magnet surrounding the RF cavity and configured to produce an axial magnetic field. The mode converter is configured to excite a rotating TE-111 mode in the RF cavity. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443900 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/12 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/16 (20130101) Original (OR) Class H05H 13/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240279109 | TOPPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Brian TOPPER (Albuquerque, New Mexico); Arash MAFI (Albuquerque, New Mexico); Johann Richard WEBER (Arlington Heights, Illinois); Stephen Kenneth WILKE (Evanston, Illinois) |
| ABSTRACT | According to examples of the present disclosure, a glass product is disclosed that includes a composition of which comprises at least 50 molar percent titanium dioxide and at least 0.1 molar percent rare earth metal oxide wherein the rare earth is at least one of the following elements: scandium, yttrium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443686 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 3/127 (20130101) Original (OR) Class C03C 4/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279485 | Smith, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph G. Smith, JR. (Smithfield, Virginia); Christopher J. Wohl, JR. (Portsmouth, Virginia) |
| ABSTRACT | Various embodiments provide ice mitigating surface coatings and methods for applying ice mitigating surface coatings. Various embodiment ice mitigating surface coatings may be formed by hydrolysis of one or more substituted n-alkyldimethylalkoxysilanes terminated with functionalities having the following characteristics with respect to water: 1) non-polar interactions; 2) hydrogen bonding through donor and acceptor interactions; or 3) hydrogen bonding through acceptor interactions only. The substituted n-alkyldimethylalkoxysilanes of the various embodiments may include methyl terminated species, hydroxyl terminated species, ethylene glycol terminated species, and methoxyethylene glycol terminated species. Various embodiment ice mitigating surface coatings may be applied to metal surfaces, such as aluminum surfaces. Various embodiment substituted n-alkyldimethylalkoxysilanes may have an aliphatic chain that is saturated and liner or branched or that is partially unsaturated and liner or branched. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640062 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 15/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/18 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/00 (20130101) C09D 5/1625 (20130101) Original (OR) Class C09D 7/63 (20180101) C09D 183/04 (20130101) C09D 183/06 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/125 (20130101) C23C 2222/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282934 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/638486 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/18 (20130101) H01B 1/24 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/387 (20130101) H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240276988 | Carbone |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ignazio Carbone (Raleigh, North Carolina) |
| ABSTRACT | The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MAT1-2). |
| FILED | Wednesday, April 10, 2024 |
| APPL NO | 18/631626 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/30 (20200101) A01N 63/34 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240279675 | Simon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of California (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); The Regents of the University of California (College Park, California) |
| INVENTOR(S) | Anne Elizabeth Simon (Upper Marlboro, Maryland); Jingyuan Liu (College Park, Maryland); Georgios Vidalakis (Riverside, California); Sohrab Bodaghi (Laguna Niguel, California) |
| ABSTRACT | The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of systemic and phloem-limited movement and replication within the host plant. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/775822 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8281 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240279858 | Pourdeyhimi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Behnam Pourdeyhimi (Cary, North Carolina) |
| ABSTRACT | The present disclosure provides a nonwoven material including a blend of a first plurality of monocomponent fibers and a second plurality of segmented fibers having segments of a first polymer and segments of a second polymer different from the first polymer, wherein the nonwoven material includes about 75 to about 95% by weight of the monocomponent fibers, and about 5 to about 25% by weight of the segmented fibers, based on the total weight of the nonwoven material, and wherein the segmented fibers are at least partially fibrillated or split. An air filter including the nonwoven material is also provided. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/444129 |
| CURRENT CPC | Separation B01D 29/031 (20130101) B01D 2201/12 (20130101) B01D 2221/00 (20130101) B01D 2239/064 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/06 (20130101) D01F 8/14 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 13/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240283211 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland); University of Massachusetts (Hadley, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiyuan LU (Montgomery Village, Maryland); Kartik SRINIVASAN (Gaithersburg, Maryland); Andrew MCCLUNG (Florence, Massachusetts) |
| ABSTRACT | A system for injection locking, including a light source configured to pump a first color light and a device configured to enable injection locking. The device includes a waveguide configured to couple to the light source and a microring resonator coupled to the light source via the waveguide. The microring resonator is a photonic crystal ring configured to enable injection locking. The microring resonator is configured to operate at a bandgap closing point, where reflection at a single frequency occurs. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/582916 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0627 (20130101) H01S 3/1083 (20130101) Original (OR) Class H01S 3/10092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240277631 | Barnett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia); Temple University-Of the Commonwealth System of Higher Education (Philadelpha, Pennsylvania); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John B. Barnett (Morgantown, West Virginia); Werner Geldenhuys (Morgantown, West Virginia); Jonathan Soboloff (Phildelphia, Pennsylvania); Harry Colbert Blair (Pittsburgh, Pennsylvania); Jamie McCall (Morgantown, West Virginia) |
| ABSTRACT | A method of inhibiting the development of osteoclasts in patients having multiple myeloma comprising administering to a patient having multiple myeloma a therapeutically effective amount of N-Methyl-dichloropropionaniline (i.e. also known as ELP-004) for inhibiting the development of osteoclasts. The method includes wherein said N-Methyl-dichloropropionaniline is administered to said patient in a pharmaceutically acceptable vehicle. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/438308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/136 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240277901 | Cullen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Mary Hitchcock Memorial Hospital, for itself and on behalf of Dartmouth-Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Kacy Cullen (Media, Pennsylvania); Justin C. Burrell (Philadelphia, Pennsylvania); Joseph M. Rosen (Lyme, New Hampshire) |
| ABSTRACT | In various aspects and embodiments, the invention provides a tissue engineered neuromuscular interface comprising: an extracellular matrix core; the extracellular matrix core comprising: a population of neurons at a first end of the extracellular matrix core, the population of neurons having axons extending at least a portion of the way along the extracellular matrix core; wherein the population of neurons is selected from the group consisting of one or more motor neurons, one or more motor neurons co-cultured with one or more sensory neurons, and a co-aggregate comprising one or more motor neurons and one or more sensory neurons. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/568560 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/383 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 27/3878 (20130101) Original (OR) Class A61L 2430/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240280535 | Ham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donhee Ham (Cambridge, Massachusetts); Woo-Bin Jung (Cambridge, Massachusetts); Han Sae Jung (Cambridge, Massachusetts); Jun Wang (Cambridge, Massachusetts); Young-Ha Hwang (Cambridge, Massachusetts); Henry Julian Hinton (Cambridge, Massachusetts); Jeffrey T. Abbott (Cambridge, Massachusetts); Hongkun Park (Cambridge, Massachusetts) |
| ABSTRACT | Devices and methods for controlling the local pH of solutions (e.g., for parallelized polymer synthesis) are generally described. These may offer several advantages, including the ability to control pH using a plurality of pixels, and/or the ability to sense the pH associated with each pixel, according to certain embodiments. In some embodiments, such devices are used to selectively synthesize polymer sequences (e.g., DNA sequences) associated with each pixel. The pixels can, in some embodiments, comprise electrodes that can apply an electrical potential or current to a solution comprising an electrically sensitive pH modifier. In some cases, reaction of the electrically sensitive pH modifier may cause a change in pH. The pixels may comprise circuit components that can operate in multiple modes (e.g. as potentiostats, galvanostats, or open-circuit potential sensors capable of sensing local pH). |
| FILED | Monday, June 13, 2022 |
| APPL NO | 18/569809 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/27 (20130101) G01N 27/302 (20130101) G01N 27/4167 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281582 | BARKER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating timing libraries. The apparatus includes a memory and a processor. The processor determines a condition that indicates whether a superconducting electronic circuit design passes or fails logic verification and determines an edge-of-failure value for a timing parameter for the superconducting electronic circuit design. The processor simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a first process variation to produce a first timing value for the superconducting electronic circuit design and simulates the superconducting electronic circuit design using the edge-of-failure value for the timing parameter and a second process variation to produce a second timing value for the superconducting electronic circuit design. The processor generates a timing library for the superconducting electronic circuit design based at least in part on the first timing value and the second timing value. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/110932 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3315 (20200101) Original (OR) Class G06F 2111/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240278421 | CHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Austin, Texas); Forrest GREEN (Austin, Texas); Peter WORSNOP (Bethesda, Maryland); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495633 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240282934 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies, Inc. (Alameda, California); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Wednesday, April 17, 2024 |
| APPL NO | 18/638486 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/18 (20130101) H01B 1/24 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/387 (20130101) H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/10 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240280067 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Wenling Lin (Montgomery, Ohio); David Herman (Beavercreek, Ohio); Trevor Howard Wood (Clifton Park, New York); Nikolai N. Pastouchenko (Latham, New York); Kishore Ramakrishnan (Rexford, New York); Timothy Richard DePuy (Liberty Township, Ohio); Robert William Davidoff (Carnegie, Pennsylvania) |
| ABSTRACT | An acoustic core may include an array of resonant cells configured as a plurality of resonant cell groups. The resonant cell groups may include a plurality of resonant cells configured as a partitioned resonant cell that include a converging resonant cell and a diverging resonant cell. The converging resonant cell and the diverging resonant cell may be defined by a plurality of cell walls integrally formed with one another and a partition integrally formed with the plurality of cell walls. The partition may at least partially delimit the converging resonant cell from the diverging resonant cell. The converging resonant cell may define an upper resonant space delimited by the partition and a top face of the array of resonant cells. The diverging resonant cell may define a lower resonant space delimited by the partition and a bottom face of the array of resonant cells. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639511 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 1/827 (20130101) Original (OR) Class Wind Motors F03D 80/00 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2260/96 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/963 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/161 (20130101) G10K 11/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20240282409 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Tao WANG (Coppell, Texas); Yi Han (Dallas, Texas); Tianshi Lu (Dallas, Texas); Yuqiu Yang (Dallas, Texas) |
| ABSTRACT | The disclosed technology relates to a computer-implemented method for predicting T cell receptor (TCR) binding specificities towards T cell antigen targets (namely, peptide-major histocompatibility complexes, pMHCs), and a set of extensions of this method, include prediction of immune-related adverse events (irAEs) using a machine learning model. The method involves obtaining genomic and proteomic data from patients, determining TCR and pMHC sequences by analyzing these data, and predicting binding interactions between T cell antigens and the TCRs. The extensions include: (a) a transfer learning model for improving the predictive performance of a pre-trained TCR-antigen binding model as a foundation model, to enhance prediction for a specific pMHC, (b) a biomarker metric defined based on the output of the TCR-pMHC binding prediction method, for diagnosis, prognosis and response prediction purposes, (c) a method, based on the output of the TCR-pMHC binding prediction method, to select optimal antigens for tumor vaccines. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650820 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) Original (OR) Class G16B 25/10 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240278497 | Spicer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randy L. Spicer (Sterling, Virginia); Thomas A. Cote (Brambleton, Virginia); Fatima Miranda (Arlington, Virginia) |
| ABSTRACT | An apparatus for additively manufacturing an article includes a heat block, a nozzle in operable communication with the heat block and configured to receive a feed material, a heat break coupled to the heat block, at least a portion of the heat break extending into the heat block, and a radiator secured to at least one surface of the heat break. Related tools for additively manufacturing a material in a vacuum and related methods are also disclosed. |
| FILED | Tuesday, February 21, 2023 |
| APPL NO | 18/171966 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/209 (20170801) B29C 64/295 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240281020 | FIELD |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | L3Harris Technologies, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael FIELD (Huntington Beach, California) |
| ABSTRACT | A sorting circuit includes: a stack of registers for storing a set of data values from a highest value to a lowest value; a set of comparators for substantially simultaneously comparing an input data value to the set of data values stored in the registers, where the comparators enable registers whose stored data values are less than the input data values to receive a replacement data value; and a set of multiplexers, each associated with a register in the stack to select the replacement data value when the register is enabled. The multiplexer selects the input data value to be the replacement data value if the register is the highest register in the stack currently storing a data value that is less than the input data value. Otherwise, the multiplexer selects the data value stored in the next-highest register in the stack to be the replacement data value. |
| FILED | Wednesday, February 22, 2023 |
| APPL NO | 18/172582 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240283682 | Agee |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brian G. Agee (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian G. Agee (San Jose, California) |
| ABSTRACT | An apparatus and digital signal processing means are disclosed for excision of co-channel interference from signals received in crowded or hostile environments using spatial/polarization diverse arrays, which reliably and rapidly identifies communication signals with transmitted features that are self-coherent over known framing intervals due to known attributes of the communication network, and exploits those features to develop diversity combining weights that substantively excise that cochannel interference from those communication signals, based on differing diversity signature, timing offset, and carrier offset between the network signals and the co-channel interferers. Co-channel interference excision may be performed in an appliqué that can be implemented without coordination with a network transceiver. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/624025 |
| CURRENT CPC | Transmission H04B 7/0617 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/08 (20130101) Original (OR) Class H04L 27/264 (20130101) H04L 27/26414 (20210101) H04L 27/26538 (20210101) Wireless Communication Networks H04W 28/14 (20130101) H04W 52/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 22, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240822.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page