FedInvent™ Patent Applications
Application Details for Thursday, August 29, 2024
This page was updated on Wednesday, September 04, 2024 at 04:12 AM GMT
Department of Health and Human Services (HHS)
| US 20240284863 | Nuzhdin et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Nuzhdin (Los Angeles, California); Melisa Osborne (Los Angeles, California); Gary Molano (Los Angeles, California); Bernadeth Tolentino (Los Angeles, California) |
| ABSTRACT | This disclosure describes the microbial network and community assembly patterns of brown macro algae, e.g., Macrocystis pyrifera gametophyte germplasm, cultures used to cultivate an offshore farm and identify network features associated with increased biomass of mature sporophytes. Several network features, such as clustering coefficient and edge ratios, significantly vary with biomass outcomes; also, gametophytes that become low- or high biomass sporophytes have different hub taxa. This disclosure describes microbial community dynamics in M. pyrifera germplasm cultures and development of early life stage inoculants used on seaweed cultivars to increase biomass yield. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589339 |
| CURRENT CPC | Harvesting; Mowing A01D 44/00 (20130101) Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 13/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240284901 | Uygun et al. |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
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| INVENTOR(S) | Mustafa Korkut Uygun (Boston, Massachusetts); Bote G. Bruinsma (Boston, Massachusetts); Maria-Louisa Izamis (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to organ perfusion systems that can be used at room temperature. The organ perfusion systems do not comprise a temperature controller. In some embodiments, the organ perfusion systems do not comprise a cleaning device for cleaning the perfusion fluid. The perfusion fluid can comprise Williams' medium E. The organ perfusion systems can be portable and can be used to preserving an organ, preventing ischemic damage in an organ, or recovering an ischemically damaged organ. |
| FILED | Thursday, February 01, 2024 |
| APPL NO | 18/430191 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) A01N 1/0247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285180 | CLOSSON et al. |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
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| INVENTOR(S) | Andrew CLOSSON (West Fairlee, Vermont); John X.J. ZHANG (Hanover, New Hampshire); Congran JIN (White River Junction, Vermont) |
| ABSTRACT | A system includes piezoelectric nanofibers, an encapsulation polymer, and patterned electrodes in an array. The array structure of the electrodes can create separate piezoelectric sensor elements, which can detect pressure from pressure such as arterial pulse waves. The sensors arrays can be used to detect the pulse wave velocity of the arterial pulse while it is superficial to near-surface arteries. This can enable detection of blood pressure in a wireless manner. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 18/578900 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/024 (20130101) A61B 5/743 (20130101) A61B 5/02125 (20130101) Original (OR) Class A61B 5/6807 (20130101) A61B 5/6822 (20130101) A61B 5/6824 (20130101) A61B 2560/045 (20130101) A61B 2560/0468 (20130101) A61B 2562/028 (20130101) A61B 2562/046 (20130101) A61B 2562/125 (20130101) A61B 2562/164 (20130101) A61B 2562/166 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285200 | SHAKED et al. |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Abraham SHAKED (Wynnewood, Pennsylvania); Bao-Li CHANG (Paoli, Pennsylvania); Brendan KEATING (Philadelphia, Pennsylvania); Toumy GUETTOUCHE (Miami, Florida) |
| ABSTRACT | The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges. |
| FILED | Wednesday, April 24, 2024 |
| APPL NO | 18/645106 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/15 (20130101) Original (OR) Class A61B 10/007 (20130101) A61B 10/0038 (20130101) A61B 2010/0061 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 25/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285233 | Pinsky |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael R. Pinsky (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system includes a processor comprising a multivariate predictive model. The multivariate predictive model can be configured to classify responses of a plurality of subjects to a stimulus, predict at least one of a response or an intervention of a target subject to the stimulus based on the classified responses, and adjust a tissue metabolic adequacy of the target subject based on at least one of the predicted response or the predicted intervention of the target subject. The stimulus can include a physical stress, a disease-related stress, a severity of stress, a severity of insult, an external environment condition, or combinations thereof. The tissue metabolic adequacy can be calculated based on a vasomotor tone, a ventricular pump function, an effective circulatory volume, or combinations thereof. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/625333 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4884 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285244 | Gao et al. |
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| APPLICANT(S) | Fei Gao (Sunnyvale, California); Yi Su (Tempe, Arizona); Jay Shah (Tempe, Arizona); Teresa Wu (Tempe, Arizona) |
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| INVENTOR(S) | Fei Gao (Sunnyvale, California); Yi Su (Tempe, Arizona); Jay Shah (Tempe, Arizona); Teresa Wu (Tempe, Arizona) |
| ABSTRACT | Using deep learning, imaging harmonization among images produced with differing PET tracers is achieved. A method may include providing an original PET image of the brain using an original PET tracer, providing a target PET tracer, and converting, using a deep learning neural network, the original PET image into a target PET image simulating the image that would be obtained had the target PET tracer been used. |
| FILED | Thursday, May 09, 2024 |
| APPL NO | 18/659581 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 15/00 (20130101) Pictorial Communication, e.g Television H04N 19/117 (20141101) H04N 19/176 (20141101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285432 | Keller et al. |
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| APPLICANT(S) | Centricity Vision, Inc. (Carlsbad, California) |
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| INVENTOR(S) | Christopher Guild Keller (El Cerrito, California); Thomas Haynes McGaffigan (Saratoga, California); Kevin L. Waltz (Indianapolis, Indiana); Thomas Milton McNicholas (Laguna Niguel, California) |
| ABSTRACT | Embodiments of the invention provide hydrodis section and /or PCO prevention or reduction in a patient undergoing eye surgery. In one embodiment, the invention is a surgical device for cutting and excising a portion of tissue, for example in performing a lens capsulotomy. A capsulotomy tip is inserted into an eye through an incision in the surface of the eye. The capsulotomy tip includes a suction cup to provide suction to the lens capsule. Then suction is applied via the suction cup to secure the capsulotomy tip to the eye. In some embodiments, after the capsulotomy tip is secured to the lens capsule, a cutting element of the capsulotomy tip is used to cut a tissue of the eye. Fluid is pushed through the capsulotomy tip and the capsulotomy tip is removed from the eye. Moreover, disclosed is an intraocular lens (IOL) to be used in conjunction with the surgical device. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653821 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/08 (20130101) A61B 2018/00291 (20130101) A61B 2018/00321 (20130101) A61B 2018/00601 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/16 (20130101) A61F 9/008 (20130101) A61F 9/00754 (20130101) Original (OR) Class A61F 2009/00889 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/77 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285531 | Nel et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Jeffrey I. Zink (Sherman Oaks, California); Huan Meng (Los Angeles, California) |
| ABSTRACT | A submicron structure comprising a silica body defining a plurality of pores that are suitable to receive molecules therein, and having a surface, and a phospholipid bilayer coating the surface, wherein said submicron structure has a maximum dimension of less than one micron, and wherein the phospholipid bilayer stably seals the plurality of pores; and wherein the submicron structure is a member of a monodisperse population of submicron structures. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/429272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 31/337 (20130101) A61K 31/713 (20130101) A61K 31/4709 (20130101) A61K 31/7068 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) A61K 47/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285543 | Bradbury et al. |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Sloan-Kettering Institute for Cancer Research (New York, New York); Memorial Hospital for Cancer and Allied Diseases (New York, New York); Cornell University (Ithaca, New York); The Curators of the University of Missouri (Columbia, Missouri) |
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| INVENTOR(S) | Michelle S. Bradbury (Ithaca, New York); Michael Overholtzer (Glen Ridge, New Jersey); Virginia Aragon (New York, New York); Gabriel DeLeon (Ithaca, New York); Ulrich Wiesner (Ithaca, New York); Thomas P. Quinn (Columbia, Missouri); Michael R. McDevitt (New York, New York) |
| ABSTRACT | Described herein are methods of treating cancer by administering to a subject a composition comprising ultrasmall silica nanoparticles to enhance one or more of the following immunotherapies: chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint blockade antibody therapy (ICB), immune inhibitor therapy (e.g., myeloid-targeting inhibitors). In some embodiments, the compositions are used in combination with external beam radiotherapy. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 18/572423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 39/3955 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 47/6929 (20170801) A61K 51/088 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 2005/109 (20130101) A61N 2005/1089 (20130101) A61N 2005/1098 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285545 | Suk et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Federal University of Rio De Janeiro (Universidade Federal do Rio de Janeiro, Brazil) |
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| INVENTOR(S) | Jung Soo Suk (Clarksvillle, Maryland); Luisa Helena Andrade Da Silva (Rio de Janeiro, Brazil); Patricia Rocco (Rio de Janeiro, Brazil); Marcelo Morales (Rio de Janeiro, Brazil) |
| ABSTRACT | An inhalable nanocrystal-based suspension formulation of nintedanib (NTB) (NTB-NS) possessing specific physicochemical properties to enhance drug retention in the lung was developed for localized treatment of pulmonary fibrosis via inhalation. This NTB-NS formulation was prepared using a wet-milling procedure in the presence of a surfactant, PLURONIC® F127, to endow the formulation with non-adhesive surface coatings to minimize interactions with therapy-inactivating delivery barriers in the lung. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 9/5123 (20130101) A61K 9/5146 (20130101) Original (OR) Class A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285552 | Olaleye |
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| APPLICANT(S) | Texas Southern University (Houston, Texas) |
| ASSIGNEE(S) | Texas Southern University (Houston, Texas) |
| INVENTOR(S) | Omonike A. Olaleye (Houston, Texas) |
| ABSTRACT | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has emerged as an ongoing global pandemic. Presently, there are no clinically approved vaccines nor drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. One or more members of the 8-Hydroxyquinoline and Benzylamine structural classes inhibited SARS-CoV-2 infection induced cytopathic effect in vitro, inhibited the exopeptidase activity of angiotensin converting enzyme 2 (ACE2), and disrupted the binding between ACE2 and the Spike protein of SARS-CoV-2. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class A61K 33/30 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285555 | Soma et al. |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Shivatheja Soma (College Station, Texas); Vishal M. Gohil (College Station, Texas); James C. Sacchettini (College Station, Texas); Liam Guthrie (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure relates to a method of restoring cytochrome c oxidase (CcO) activity in a subject in need thereof. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog thereof and rescuing defects of cells in the subject with deficiencies or mutations in at least one of SOD1, AT-1, APIS1, COA6, SCO2, COX6B1, CTR1, ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, and CLCN7. In a further embodiment, the present disclosure relates to a method of treating disorders of copper metabolism. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog to a subject, where the disorder is caused by a deficiency or mutation to a gene including, without limitation, SOD1, AT-1, APIS1, COA6, SCO2, COX6B1, CTR1, ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, CLCN7, or combinations thereof. |
| FILED | Wednesday, May 01, 2024 |
| APPL NO | 18/652683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) Original (OR) Class A61K 33/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285556 | Chen et al. |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
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| INVENTOR(S) | Ching-Shih Chen (Columbus, Ohio); Christopher C. Coss (Columbus, Ohio); Samuel Kulp (Columbus, Ohio); Yu-Chou Tseng (Columbus, Ohio); Tanios Bekaii-Saab (Columbus, Ohio) |
| ABSTRACT | In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285575 | Majeti et al. |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
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| INVENTOR(S) | Ravikumar Majeti (Tuscaloosa, Alabama); Meenakshi Arora (Tuscaloosa, Alabama); Ingrid Marie Heyns (Tuscaloosa, Alabama); Raghu Ganugula (Tuscaloosa, Alabama) |
| ABSTRACT | Disclosed herein are compositions of nanoparticles with naringenin as a folate receptor (FR)-targeting ligand and methods of making and administering the nanoparticles with naringenin (NAR) ligands for drug delivery applications. The disclosed compositions include NAR-functional polyester-based nanoparticles encapsulating insulin (i.e. insulin-laden NAR-functional nanoparticles), which showed loading capacities of 10% and encapsulation efficiency of >70%. The insulin-laden NAR-functional nanoparticles are shown in examples to have a 3-fold higher bioavailability of insulin compared to unfunctionalized nanoparticles, suggesting the role of receptor-mediated transport across the intestinal barriers. Methods of making NAR-functional nanoparticles are also disclosed herein, and methods of administration for the peroral delivery of encapsulated drugs. |
| FILED | Wednesday, December 27, 2023 |
| APPL NO | 18/397327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/593 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/50 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285580 | Htoo et al. |
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| APPLICANT(S) | Qlaris Bio, Inc. (Dedham, Massachusetts); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Qlaris Bio, Inc. (Dedham, Massachusetts); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Thurein M. Htoo (Westwood, Massachusetts); Barbara M. Wirostko (Park City, Utah); Michael P. Fautsch (Rochester, Minnesota) |
| ABSTRACT | Extended-release pharmaceutical compositions comprising a biodegradable microparticle, nanoparticle or other polymeric formulation of Formula I, Formula IL, or Formula III or a pharmaceutically acceptable salt thereof are provided with advantageous properties for in vivo delivery to a patient in need thereof. The extended-release formulations overcome historic obstacles in cromakalim, including levcromakalim, delivery. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/439552 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4025 (20130101) Original (OR) Class A61K 47/50 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285598 | Ghosh et al. |
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| APPLICANT(S) | Arun K. Ghosh (West Lafayette, Indiana); Monika Yadav (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Monika Yadav (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana) |
| ABSTRACT | Disclosed are bis-amide inhibitors of SARS-CoV-2 (CO VID), and methods of using them to treat a severe acute respiratory syndrome. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 18/564748 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4015 (20130101) A61K 31/4025 (20130101) A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 207/26 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/14 (20130101) C07D 493/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285630 | YEAGER |
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| APPLICANT(S) | MEZZION PHARMA CO., LTD. (Deerfield, Illinois) |
| ASSIGNEE(S) | MEZZION PHARMA CO., LTD. (Deerfield, Illinois) |
| INVENTOR(S) | James L. YEAGER (Deerfield, Illinois) |
| ABSTRACT | Various methods and compositions for treating single ventricle heart disease (SVHD) patients, including patients who have undergone Fontan surgery and who have Fontan circulation (Fontan patient), to improve exercise performance, especially to improve exercise performance at peak or max VO2 in a sub-super Fontan population, i.e., a subgroup of Fontan patients who have a baseline peak or max VO2 of less than (<) 80% predicted, and to improve exercise performance at ventilatory anaerobic threshold (“VAT”) in both the super Fontan population, i.e., Fontan patients who have a baseline peak or max VO2 of greater than (≥) 80% predicted, and the sub-super Fontan population. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 17/803841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285631 | Hirschi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Karen K. Hirschi (Charlottesville, Virginia); Gael Genet (Charlottesville, Virginia); Shelby Rose Cain (Charlottesville, Virginia); Nafiisha Genet (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen K. Hirschi (Charlottesville, Virginia); Gael Genet (Charlottesville, Virginia); Shelby Rose Cain (Charlottesville, Virginia); Nafiisha Genet (Charlottesville, Virginia) |
| ABSTRACT | The present disclosure provides for methods of treating vascular malformation using cell cycle inhibitors, such as palbociclib, ribociclib, CVT-313, and abemaciclib, as well as pharmaceutical compositions. The methods can include treating adults that have developed a vascular malformation, treating neonates that may develop a vascular malformation, or treating children that have developed a vascular malformation or that may develop a vascular malformation. |
| FILED | Wednesday, January 31, 2024 |
| APPL NO | 18/428746 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285643 | UEHARA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Shionogi and Co., Ltd. (Osaka, Japan); F. HOFFMANN-LA ROCHE AG (Basel, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Takeki UEHARA (Osaka, Japan); Toru ISHIBASHI (Osaka, Japan); Takao SHISHIDO (Osaka, Japan); Keita FUKAO (Osaka, Japan); Motoyasu OONISHI (Osaka, Japan); Barry CLINCH (Welwyn Garden City, United Kingdom); Jaspinder RANDHAWA (Welwyn Garden City, United Kingdom) |
| ABSTRACT | A method for treating an influenza virus infection is described. The disclosed method generally involves administering an effective amount of a compound (A), for example baloxavir marboxil, and a compound (B), for example a neuraminidase inhibor, to a subject that (1) has an influenza virus infection, (2) has been symptomatic of the influenza virus infection for no more than 96 hours, and (3) further has at least one severe influenza condition selected from the following: (a) being hospitalized due to severe influenza virus infection, (b) requiring an extension of hospitalization because of the influenza virus infection during the hospitalization, (c) having a National Early Warning Score 2 of four or more, (d) being on support for respiration, and (e) having at least one complication attributable to the influenza virus infection that necessitates hospitalization. |
| FILED | Tuesday, March 12, 2024 |
| APPL NO | 18/602656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/215 (20130101) A61K 31/5383 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285647 | Sobol et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Alabama Foundation for Research and Commercialization (Mobile, Alabama); Canal House Biosciences, LLC (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Sobol (Providence, Rhode Island); Jay George (Gaithersburg, Maryland) |
| ABSTRACT | The present invention relates to methods for the treatment of cancers, as well as pharmaceutical preparations of compounds useful in such treatments. |
| FILED | Monday, October 17, 2022 |
| APPL NO | 18/571452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/145 (20130101) A61K 31/454 (20130101) A61K 31/501 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/4045 (20130101) A61K 31/5377 (20130101) A61K 31/5517 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285650 | MCCALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ReveraGen BioPharma, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. MCCALL (Boca Grande, Florida); Eric HOFFMAN (Rockville, Maryland); Kanneboyina NAGARAJU (Highland, Maryland) |
| ABSTRACT | The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-κB for the treatment or prevention of muscular wasting disease, including muscular dystrophy. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) A61K 31/573 (20130101) Original (OR) Class A61K 31/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) A61P 1/16 (20180101) A61P 3/00 (20180101) Steroids C07J 5/0038 (20130101) C07J 5/0053 (20130101) C07J 5/0076 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285659 | ZWICKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Jeffrey I. ZWICKER (Boston, Massachusetts); Bruce FURIE (Boston, Massachusetts); Jack Davis STOPA (Boston, Massachusetts); Robert FLAUMENHAFT (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to methods for reducing soluble P-selectin and major thrombotic events in cancer patients. |
| FILED | Friday, January 12, 2024 |
| APPL NO | 18/412414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/45 (20130101) A61K 31/352 (20130101) A61K 31/375 (20130101) A61K 31/519 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285668 | Marbán et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Marbán (Santa Monica, California); Ahmed G. Ibrahim (Los Angeles, California) |
| ABSTRACT | Provided herein are formulations configured for the oral delivery of a nucleic acid, such as a non-coding RNA. The formulations provided for herein comprise a plurality of cationic lipids used to encapsulate the nucleic acid within a micelle and a mixture of casein proteins and chitosan polymers used to coat the lipids, which form a coating on the micelle. The coated micelle lends acid-resistance to the formulation such that oral administration is possible with enhanced bioavailability of the nucleic acid to conditions associated with inflammation or fibrosis, such as hypertrophic myocardiopathy, heart failure with preserved ejection fraction, muscle disorders, such as muscular dystrophy, scleroderma and/or viral infection. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/572067 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/1075 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 47/12 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) A61P 9/10 (20180101) A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285676 | Hassler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Franklin Hassler (Minneapolis, Minnesota); Adelyn Crabtree (Minneapolis, Minnesota); Benjamin Hackel (Minneapolis, Minnesota); Frank S. Bates (Minneapolis, Minnesota); Timothy P. Lodge (Minneapolis, Minnesota); Joseph M. Metzger (Minneapolis, Minnesota) |
| ABSTRACT | The present disclosure relates to bottlebrush polymers and methods thereof. Methods can include methods of stabilizing an interface, stabilizing a cell, or treating a disease, disorder, or condition using an effective amount of the bottlebrush polymer. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/438184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/77 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 21/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 65/08 (20130101) C08G 83/005 (20130101) C08G 2261/75 (20130101) C08G 2261/126 (20130101) C08G 2261/132 (20130101) C08G 2261/354 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285683 | Rabinowitz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Rabinowitz (Princeton, New Jersey) |
| ABSTRACT | The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to a subject a population of immune cells that express an exogenous enzyme that facilitates immune cell function in a nutrient-poor environment. Other embodiments of the invention include methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to the subject an effective amount of an agent that provides a one-carbon unit (e.g., formate) and an agent that promotes an anti-tumor response, and methods of promoting an immune response to a tumor in a subject in need thereof, comprising administering to a subject an effective amount of an agent that inhibits consumption of metabolic fuels by tumor cells. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an exogenous enzyme that enhances immune cell function in nutrient poor environments, and compositions comprising a nucleic acid expression construct encoding an inhibitor of glucose metabolism, and a pharmaceutically acceptable carrier or excipient. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 16/2818 (20130101) C07K 16/3084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/0036 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2500/02 (20130101) C12N 2501/71 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285707 | Archibong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee) |
| ASSIGNEE(S) | Meharry Medical College (Nashville, Tennessee) |
| INVENTOR(S) | Anthony E. Archibong (Antioch, Tennessee); G. William Bates (Brentwood, Tennessee); Elochukwu J. Ezekakpu (Nashville, Tennessee); Lorin W. SIMON (Antioch, Tennessee); James E.K. Hildreth (Nashville, Tennessee) |
| ABSTRACT | Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium. |
| FILED | Thursday, May 09, 2024 |
| APPL NO | 18/659048 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0221 (20130101) Diagnosis; Surgery; Identification A61B 17/43 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0034 (20130101) A61K 36/185 (20130101) Original (OR) Class A61K 2236/33 (20130101) A61K 2236/39 (20130101) A61K 2236/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285727 | Cohen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Pinchas Cohen (Los Angeles, California); Brendan Miller (Los Angeles, California); Su-Jeong Kim (Los Angeles, California) |
| ABSTRACT | Described herein is a novel, mitochondrial encoded, open reading frame that leads to the production of a new mitochondrial peptide called SHMOOSE. SHMOOSE is a 58-amino-acid peptide and, within its open reading frame, contains a genome-wide significant small nucleotide polymorphism (SNP) that markedly increased risk for Alzheimer's disease, brain structure, brain gene expression, and cognition. SHMOOSE increased neuronal-type cell survival and protected against amyloid beta toxicity. Metabolomic studies revealed a role for the peptide in energy optimization, whose dysfunction and dysregulation leads to cell death in physiologically notable regions of the brain in neurodegenerative diseases such as Alzheimer's and Parkinson's. Methods and compositions, including peptide analogues and derivatives, are described for treatment and diagnostics. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 18/565306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/50 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285728 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Peixin YANG (Ellicott City, Maryland); ALBERT E. REECE (Lutherville, Maryland); University of Maryland, Baltimore (Baitimore, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Peixin Yang (Ellicott City, Maryland); E. Albert REECE (Lutherville, Maryland) |
| ABSTRACT | Methods for preventing neural tube defects in embryos of diabetic females via administration of Survivin-containing exosomes derived from Flk-1+ mesoderm progenitor cells are reported. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/568036 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5184 (20130101) A61K 38/1761 (20130101) Original (OR) Class A61K 38/1825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285733 | ALENGHAT |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theresa ALENGHAT (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for enhancing an immune response in an individual in need thereof. The methods, in certain aspects, may comprise administering bacterial aldehyde dehydrogenase, a bacteria that produces aldehyde dehydrogenase, or combinations thereof to an individual. Further disclosed are compositions, such as nutritional compositions, which may comprise bacterial aldehyde dehydrogenase, a bacteria that produces aldehyde dehydrogenase, or combinations thereof. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/625448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 37/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) Enzymes C12Y 102/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285740 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Kenneth C. Anderson (Wellesley, Massachusetts); Jooeun Bae (West Roxbury, Massachusetts) |
| ABSTRACT | This disclosure features human Lymphocyte-activation gene 3 (LAG3) and human Galectin-3 (GAL3) inhibitory agents, immunogenic peptides X-Box Binding Protein 1 (XBP1), CD2 Subset 1 (CS1), and CD138 peptides, and methods of using the inhibitory agents and peptides to treat blood cancers and pre-cancerous conditions. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 18/289780 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 38/1774 (20130101) A61K 39/001111 (20180801) A61K 39/001129 (20180801) A61K 39/001152 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 39/4611 (20230501) A61K 45/06 (20130101) A61K 2039/54 (20130101) A61K 2039/542 (20130101) A61K 2039/543 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285747 | LIVENGOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Takeda Vaccines, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jill A. LIVENGOOD (Cambridge, Massachusetts); HANSI DEAN (Cambridge, Massachusetts); Htay Htay HAN (Cambridge, Massachusetts); Raman RAO (Singapore, Singapore); Jackie MARKS (Cambridge, Massachusetts); Gary DUBIN (Zurich, Switzerland); Laurence DE MOERLOOZE (Zurich, Switzerland); Hetal PATEL (Cambridge, Massachusetts); Asae SHINTANI (Hikari-Shi, Japan); Holli GIEBLER (Cambridge, Ukraine); James GIFFORD (Cambridge, Massachusetts); Mark LYONS (Cambridge, Massachusetts); Sushma KOMMAREDDY (Cambridge, Massachusetts); Tatsuki SATOU (Hikari-shi, Japan) |
| ABSTRACT | The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/242025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/545 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/24134 (20130101) C12N 2770/24151 (20130101) C12N 2770/24163 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285749 | Mascola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by thew Secretary, Department of Health and Human Servi (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by thew Secretary, Department of Health and Human Servi (Bethesda, Maryland) |
| INVENTOR(S) | John R. Mascola (Rockville, Maryland); Jeffrey C. Boyington (Clarksburg, Maryland); Hadi M. Yassine (Doha, Qatar); Peter D. Kwong (Washington, District of Columbia); Barney S. Graham (Smyrna, Georgia); Masaru Kanekiyo (North Bethesda, Maryland) |
| ABSTRACT | Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies. |
| FILED | Friday, April 26, 2024 |
| APPL NO | 18/648190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/6031 (20130101) A61K 2039/55555 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) C07K 14/47 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285753 | Azoitei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mihai Azoitei (Durham, North Carolina); Daniel Marston (Durham, North Carolina); Anyway Brenda Kapingidza (Durham, North Carolina); Barton F. Haynes (Durham, North Carolina) |
| ABSTRACT | Disclosed are immunogens for stimulating an immune response to coronaviruses. The immunogens can be non-receptor binding domain (RBD) epitopes. The immunogens can be grafted into a scaffold polypeptide to produce an epitope scaffold. Antibodies induced by the immunogens are disclosed. |
| FILED | Friday, January 19, 2024 |
| APPL NO | 18/417663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) C07K 14/21 (20130101) C07K 14/28 (20130101) C07K 14/31 (20130101) C07K 14/47 (20130101) C07K 14/195 (20130101) C07K 14/245 (20130101) C07K 14/395 (20130101) C07K 14/405 (20130101) C07K 14/415 (20130101) C07K 16/1003 (20230801) C07K 2318/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285757 | Durgin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Durgin (Dexter, Michigan); Roderick O'Connor (Philadelphia, Pennsylvania); Donald M. O'Rourke (Wynnewood, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods comprising CAR T cells that secrete neuraminidase (e.g., C. perfringens neuraminidase (CpNA)). Compositions and methods of treatment are also provided. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 18/292247 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) Original (OR) Class A61K 39/4631 (20230501) A61K 39/4637 (20230501) A61K 39/464404 (20230501) A61K 2239/39 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/2402 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285760 | KWONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel A. KWONG (Atlanta, Georgia); Marielena GAMBOA (Atlanta, Georgia); Ian C. MILLER (Atlanta, Georgia); Ali ZAMAT (Atlanta, Georgia) |
| ABSTRACT | The present disclosure relates to promoter constructs comprising: one or more heat shock elements: a core promoter; and a gene of interest: vectors comprising the promoter constructs, and immune cells modified to include the promoter constructs. The promoter constructs provide the ability to remotely control immune cell therapies by thermal targeting. The present disclosure also provides methods of use for the promoter constructs. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 18/573858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4611 (20230501) A61K 39/4633 (20230501) A61K 39/4635 (20230501) Original (OR) Class A61K 39/464412 (20230501) A61K 2239/39 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/5443 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/85 (20130101) C12N 2510/00 (20130101) C12N 2800/107 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285769 | Benhabbour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soumya Rahima Benhabbour (Chapel Hill, North Carolina); Panita Maturavongsadit (Chapel Hill, North Carolina); Roopali Shrivastava (Chapel Hill, North Carolina); Isabella C. Young (Chapel Hill, North Carolina) |
| ABSTRACT | Injectable, biodegradable and removable polymer based drug suspension for ultra-long-acting drug delivery are disclosed. Ultra-long-acting in-situ forming implant (ISFI) drug suspension delivery systems as multipurpose prevention technologies for a multitude of applications are also provided. Methods of use, including treatment of subjects, using the disclosed compositions and ISFIs are also provided. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/571412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 47/20 (20130101) A61K 47/22 (20130101) Original (OR) Class A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285774 | QUIJANO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/503905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Original (OR) Class A61K 47/6807 (20170801) A61K 47/6851 (20170801) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0025 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/4747 (20130101) C07K 16/44 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/3181 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285775 | QUIJANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Elias QUIJANO (Durham, Connecticut); Peter GLAZER (Guilford, Connecticut) |
| ABSTRACT | Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/527005 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Original (OR) Class A61K 47/6807 (20170801) A61K 47/6851 (20170801) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0025 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/4747 (20130101) C07K 16/44 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/3181 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285789 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingnan Chen (Salt Lake City, Utah); Shuyun Dong (Salt Lake City, Utah); Tianxiao Zhang (Salt Lake City, Utah) |
| ABSTRACT | Disclosed are polypeptides comprising a diphtheria toxin and a PD1 targeting moiety. Disclosed are polypeptides comprising, from N- to C-terminus, a truncated diphtheria toxin, and two anti-PD-1 scFvs. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding any one of the disclosed polypeptides. Disclosed are nucleic acid constructs comprising a nucleic acid sequence encoding a diphtheria toxin linked to a nucleic acid sequence encoding a PD1 targeting moiety. Disclosed are methods of treating a subject in need thereof comprising administering to the subject a composition comprising one or more of the disclosed polypeptides, vectors, or pharmaceutical compositions. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/173680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6829 (20170801) Original (OR) Class Peptides C07K 14/34 (20130101) C07K 14/76 (20130101) C07K 16/2818 (20130101) C07K 2317/622 (20130101) C07K 2319/01 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285790 | PAZGIER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland); CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (Montreal, Quebec, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marzena PAZGIER (Derwood, Maryland); William D. TOLBERT (North Bethesda, Maryland); Dung N. NGUYEN (Beltsville, Maryland); Andres FINZI (Quebec, Canada); Jonathan RICHARD (Quebec, Canada) |
| ABSTRACT | The present disclosure provides for antibody conjugate molecules (Ab-CD4 conjugates) comprising an antibody, at least one linker, and at least one CD4 compound, wherein the at least one linker links the antibody to the at least one CD4 compound and wherein the Ab-CD4 conjugate is capable of neutralizing an HIV virus, as well as methods of killing HIV-infected cells through an Fc-mediated effector function using the Ab-CD4 conjugates. Also provided are pharmaceutical compositions comprising the Ab-CD4 conjugates and methods of treating or preventing HIV injection in a subject. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/565379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6811 (20170801) A61K 47/6841 (20170801) Original (OR) Class A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285794 | Messersmith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); LANKENAU INSTITUTE FOR MEDICAL RESEARCH (Wynnewood, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip B. Messersmith (Berkeley, California); Jing Cheng (Berkeley, California); Ellen Heber-Katz (Wynnewood, Pennsylvania) |
| ABSTRACT | Disclosed herein are PEG-DPCA conjugates having multiple hydrophobic DPCA groups at one or both terminal ends of a PEG compound and compositions thereof and methods of using thereof for tissue regeneration and/or cellular repair (e.g., wound healing). |
| FILED | Tuesday, April 23, 2024 |
| APPL NO | 18/643966 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/6903 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285801 | Kemaladewi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Dwi U. Kemaladewi (Pittsburgh, Pennsylvania); Robert David Nicholls (Pittsburgh, Pennsylvania); Jia Qi Cheng Zhang (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document provides methods and materials for treating a mammal (e.g., a human) having, or at risk of developing, muscular dystrophy (e.g., a laminin α2-related dystrophy (LAMA2-RD)). For example, an adeno-associated virus (AAV) designed for targeted gene activation of nucleic acid encoding a Lama1 polypeptide (e.g., the endogenous Lama1 gene) can be administered to a mammal (e.g., a human) having, or at risk of developing, muscular dystrophy (e.g., a LAMA2-RD) to treat the mammal. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/39 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285808 | Caravan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Caravan (Cambridge, Massachusetts); Yingying Ning (Somerville, Massachusetts); Hua MA (Somerville, Massachusetts); Sergey Shuvaev (Somerville, Massachusetts); Eman Akam (Somerville, Massachusetts) |
| ABSTRACT | Disclosed herein are methods of molecular magnetic resonance (MR) imaging and positron emission tomography using extracellular probes that target extracellular allysine aldehyde and act as a noninvasive biomarker of fibrogenesis with high sensitivity and specificity in detecting fibrogenesis, for example, in rodent models and human fibrotic tissues. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 18/290135 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) Original (OR) Class A61K 49/108 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Heterocyclic Compounds C07D 255/02 (20130101) C07D 257/02 (20130101) C07D 403/12 (20130101) C07D 417/12 (20130101) C07D 471/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 3/06 (20130101) C07F 5/003 (20130101) C07F 13/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285838 | BARTLETT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. BARTLETT (Ann Arbor, Michigan); Joseph A. POTKAY (Plymouth, Michigan) |
| ABSTRACT | An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas levels; and a feedback controller receiving the blood CO2 or O2 signal and outputting a control signal to control gas flow and/or blood flow. |
| FILED | Tuesday, April 16, 2024 |
| APPL NO | 18/636872 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1603 (20140204) Original (OR) Class A61M 1/1698 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285978 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen XU (Ann Arbor, Michigan); Timothy Lewis HALL (Ann Arbor, Michigan); Greyson STOCKER (Ann Arbor, Michigan); Man ZHANG (Ann Arbor, Michigan) |
| ABSTRACT | Minimally invasive histotripsy systems and methods are provided. In some embodiments, a minimally invasive histotripsy device is inserted into a patient. The device can be inserted endoscopically through a natural orifice of the patient, or laparoscopically through an incision in the patient's skin. The minimally invasive histotripsy device can be advanced to the target tissue and acoustically coupled to the target tissue before applying histotripsy therapy to the target tissue. In some embodiments, the minimally invasive histotripsy device includes a transducer array with a focal length of approximately 10-40 mm, a diameter of less than 35 mm, and the ability to create a peak negative focal pressure of at least 20 MPa. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 18/568038 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/4281 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0039 (20130101) A61N 2007/0043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287054 | Schneekloth et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John S. Schneekloth (Frederick, Maryland); Mo Yang (Frederick, Maryland); Xiao Liang (Frederick, Maryland); Christopher Fullenkamp (Frederick, Maryland) |
| ABSTRACT | Small molecule compounds that selectively bind to non-canonical G-quadruplex (G4) structures, such as G4s in DNA found in various types of genes described herein, along with methods of using the compounds to reduce or inhibit protein (e.g., N-Myc protein) expression in cells, such as cancer cells. The compounds have a structure according to formulas described herein, or a stereoisomer, tautomer, or pharmaceutically effective salt or ester thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568738 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/501 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 413/04 (20130101) C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287081 | SCOPTON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander P. SCOPTON (New York, New York); Ross L. CAGAN (New York, New York); Arvin C. DAR (New York, New York); Ernesto GUCCIONE (New York, New York); Alexander RIALDI (New York, New York); Slim MZOUGHI (New York, New York) |
| ABSTRACT | The present disclosure relates to compounds of formula (I) having the following structure; and to compounds of formula (II) having the structure: or stereoisomers, pharmaceutically acceptable salts, oxides, or solvates thereof, where R1, R2, R3, R4, and R5 are as described herein. The present disclosure also relates to compositions containing the compounds having the structure of formula (I) and/or formula (II), and treatment methods in a subject using the compounds and/or compositions. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287089 | Cushman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Gibson Oncology, LLC (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S. Cushman (West Lafayette, Indiana); Danzhou Yang (Lafayette, Indiana); Venkat Chintareddy (Vestavia Hills, Alabama); Pooran Chand (Birmingham, Alabama) |
| ABSTRACT | Described herein are new 8,9-dialoxy-7-azaindenoisoquinoline compounds (I), processes for their preparation, and methods of their use in the treatment of diseases responsive to inhibition of topoisomerate I and/or binding to the c-MYC G-Quadruplex. |
| FILED | Wednesday, March 27, 2024 |
| APPL NO | 18/618496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4375 (20130101) Heterocyclic Compounds C07D 491/147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287092 | Petrukhin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Konstantin Petrukhin (New Windsor, New York); Christopher Cioffi (Albany, New York); Graham Johnson (Sanbornton, New Hampshire); Nicoleta Dobri (New York, New York); Emily Freeman (Albany, New York); Ping Chen (Albany, New York); Michael Conlon (Albany, New York); Lei Zhu (Albany, New York) |
| ABSTRACT | The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/437702 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/497 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/4375 (20130101) A61K 31/4545 (20130101) A61K 31/5025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 401/06 (20130101) C07D 405/14 (20130101) C07D 409/06 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 491/052 (20130101) C07D 495/04 (20130101) C07D 498/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287108 | RAIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rana RAIS (Baltimore, Maryland); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rana RAIS (West Friendship, Maryland); Barbara SLUSHER (Kingsville, Maryland); Arindom S. PAL (Baltimore, Maryland) |
| ABSTRACT | Prodrugs of small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 18/566922 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 31/454 (20130101) A61K 31/675 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) Heterocyclic Compounds C07D 409/04 (20130101) C07D 409/14 (20130101) C07D 471/08 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65586 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287129 | MacMillan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David MacMillan (Princeton, New Jersey); Daniel Novoa (New York, New York); Stefan McCarver (Princeton, New Jersey) |
| ABSTRACT | Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640494 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/1815 (20130101) B01J 35/39 (20240101) B01J 2231/324 (20130101) B01J 2231/348 (20130101) B01J 2531/827 (20130101) B01J 2540/12 (20130101) B01J 2540/22 (20130101) B01J 2540/225 (20130101) Peptides C07K 1/107 (20130101) C07K 1/113 (20130101) Original (OR) Class C07K 5/0205 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/29 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287139 | Lewis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim Lewis (Newton, Massachusetts); Yu Imai (Boston, Massachusetts) |
| ABSTRACT | The present invention directed to a novel macrocyclic depsipeptide compound, its derivatives, and their pharmaceutically acceptable salts, having selective antibacterial activity against M. tuberculosis. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/571666 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/15 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Peptides C07K 11/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287142 | BAROUCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan H. BAROUCH (Newton, Massachusetts); Peter ABBINK (Winthrop, Massachusetts); Mark Justin IAMPIETRO (Boston, Massachusetts); Menzo J. E. HAVENGA (Boston, Massachusetts) |
| ABSTRACT | Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human). |
| FILED | Thursday, August 24, 2023 |
| APPL NO | 18/455151 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/761 (20130101) A61K 39/235 (20130101) Peptides C07K 14/075 (20130101) Original (OR) Class C07K 14/5425 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287144 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Ivelin Georgiev (Nashville, Tennessee); Michael Gordon Joyce (Washington, District of Columbia); Masaru Kanekiyo (Chevy Chase, Maryland); Aliaksandr Druz (Germantown, Maryland); Ulrich Baxa (Frederick, Maryland); Joseph Van Galen (North Wales, Pennsylvania); Cheng Cheng (Bethesda, Maryland); John Mascola (Rockville, Maryland); Yaroslav Tsybovsky (Brunswick, Maryland); Yongping Yang (Potomac, Maryland); Barney Graham (Smyrna, Georgia); Syed Mohammad Moin (Laurel, Maryland); Jeffrey Boyington (Clarksburg, Maryland) |
| ABSTRACT | Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) A61K 2039/55555 (20130101) Peptides C07K 14/11 (20130101) Original (OR) Class C07K 14/082 (20130101) C07K 14/162 (20130101) C07K 14/165 (20130101) C07K 14/43563 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16134 (20130101) C12N 2760/16134 (20130101) C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287148 | Qian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shu-Bing Qian (Ithaca, New York); Robert V. Swanda (Windsor, New York) |
| ABSTRACT | Described in several exemplary embodiments herein are engineered biomolecules that can be capable of nutrient reprogramming in a cell. Also described herein are methods of using the engineered biomolecules. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 18/578867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/30 (20130101) A61K 38/1709 (20130101) A61K 48/0033 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 14/65 (20130101) C07K 2319/06 (20130101) C07K 2319/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287150 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jungmin LEE (Cambridge, Massachusetts); Jeffrey WAY (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to engineered polypeptides comprising an anti-GYPA antibody reagent and an EPO polypeptide, such as an EPO polypeptide that is engineered to be tissue-protective. Further provided herein are methods of treating a neurodegenerative disease or disorder, hypoxic tissue damage, traumatic brain injury, or stroke by administering said polypeptides. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 18/572549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/505 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287160 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to an antibody cocktail comprising antibodies that bind to and protect subjects again multiple ebolavirus strains and methods for use thereof. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/556648 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/52 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287165 | Quiroz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); Banner Health (Phoenix, Arizona); The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yakeel T. Quiroz (Charlestown, Massachusetts); Joseph F. Arboleda-Velasquez (Newton, Massachusetts); Eric Reiman (Phoenix, Arizona); Francisco Lopera (Medellin, Colombia) |
| ABSTRACT | Methods and compositions for preventing or treating cognitive decline associated with dementia and/or mild cognitive impairment and/or neurodegeneration using antibodies, peptides, fusion proteins, or genome editing systems that modulate HSPG/heparin binding affinities of ApoE. |
| FILED | Wednesday, March 20, 2024 |
| APPL NO | 18/611325 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/775 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/92 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287171 | McNally et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IKAIKA THERAPEUTICS, INC. (Oak Park, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois); Ahlke Heydemann (Oak Park, Illinois); Ermelinda Ceco (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta binding protein (LTBP4)-induced proteolysis of a TGFβ superfamily protein. |
| FILED | Thursday, April 25, 2024 |
| APPL NO | 18/646068 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 16/18 (20130101) C07K 16/26 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287175 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); John Vincent Pluvinage (Atherton, California); Michael C. Bassik (Stanford, California); Michael Haney (Stanford, California); Benjamin Smith (Stanford, California); Carolyn Bertozzi (Stanford, California) |
| ABSTRACT | Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 39/001113 (20180801) A61K 39/3955 (20130101) A61K 47/6815 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0097 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/77 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287178 | Eichmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut); INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne Eichmann (Branford, Connecticut); Kevin Boyé (New Haven, Connecticut); Luiz Geraldo (Paris, France) |
| ABSTRACT | The present disclosure relates to compositions and methods for use in generating temporary permeability of the blood brain barrier. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/573728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287179 | LAI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laijun LAI (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein are methods for treating cancer by administering to a subject having cancer antibodies against one or more of CD300c, BTN5 (Erythroid membrane-associated protein), TAPBPL (antigen processing (TAP) binding protein like protein), Skint8 (selection and upkeep of intraepithelial T cells 8 protein), and CD300f. Also disclosed herein are methods for treating autoimmune diseases by administering to a subject having an autoimmune disease an IgV domain, or a nucleic acid encoding an IgV domain, from one or more of CD300c, BTN5, TAPBPL, Skint8, and CD300f. Also disclosed herein are antibodies against CD300c and TAPBPL, and fusion proteins that can be used in the methods for treating autoimmune disease. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/70503 (20130101) C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287240 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (College Station, Texas); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape. |
| FILED | Tuesday, April 09, 2024 |
| APPL NO | 18/630394 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 51/00 (20130101) B29C 51/002 (20130101) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) C08G 2101/00 (20130101) C08G 2280/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287430 | Streichan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Sebastian Streichan (Goleta, California); Eyal Karzbrun (Goleta, California) |
| ABSTRACT | Systems and methods for cellular luminal structure formation are provided. In some instances, a cellular luminal structure is formed utilizing a micropatterned matrix, biological cells in contact with the micropatterned matrix, and suspended matrix in media. In some instances, cellular luminal structure is utilized in conjunction with cellular differentiation. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 18/566324 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2501/155 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287457 | LUO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES AND PEKING (Tianjin, China PRC) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES AND PEKING (Tianjin, China PRC) |
| INVENTOR(S) | Hongbo R. LUO (Boston, Massachusetts); Yuping FAN (Tianjin, China PRC); Fengxia MA (Tianjin, China PRC); Yan TENG (Boston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to compositions and cell culture media for increasing the lifespan of neutrophils. Also described are methods and kits for culturing neutrophils using the compositions or cell culture media. Such cultured neutrophils can be used to treat disorders such as neutropenia or microbial infections. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/569895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) Original (OR) Class C12N 2500/33 (20130101) C12N 2501/22 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287462 | HEMATTI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiman HEMATTI (Madison, Wisconsin); John KINK (Madison, Wisconsin); Christian CAPITINI (Madison, Wisconsin); Matthew FORSBERG (Stoughton, Wisconsin); Nicholas HESS (Cottage Grove, Wisconsin); Zachary ROSENKRANS (Madison, Wisconsin); Reinier Hernandez (Madison, Wisconsin) |
| ABSTRACT | The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX. |
| FILED | Tuesday, April 02, 2024 |
| APPL NO | 18/624848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 5/0668 (20130101) Original (OR) Class C12N 2500/84 (20130101) C12N 2502/1323 (20130101) C12N 2502/1358 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287463 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher S. Chen (Newton, Massachusetts); Sangeeta N. Bhatia (Lexington, Massachusetts); Arnav Chhabra (Cambridge, Massachusetts); Amanda Chen (East Cambridge, Massachusetts); Hyun Ho Song (Long Island City, New York) |
| ABSTRACT | Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/793287 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3886 (20130101) A61L 27/3895 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0656 (20130101) C12N 5/0671 (20130101) Original (OR) Class C12N 9/6472 (20130101) C12N 2502/1323 (20130101) C12N 2513/00 (20130101) Enzymes C12Y 304/22062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287491 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Travis R. Blum (Cambridge, Massachusetts); Julia McCreary (Cambridge, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to Botulinum toxin X (BoNT X) protein variants (e.g., BoNT X protease variants). The variants provided herein have been evolved to cleave procaspase-1. Some of the variants provided herein do not cleave the native substrate of BoNT X protease, VAMP1 protein. Further aspects of the disclosure relate to nucleic acids encoding the procaspase-1 cleaving polypeptides described herein and expression vectors comprising the nucleic acids, as well as host cells and fusion proteins comprising the procaspase-1 cleaving polypeptides described herein and kits comprising the procaspase-1 cleaving polypeptides, nucleic acids, fusion proteins, expression vectors, or host cells described herein. Further aspects of the disclosure relate to methods of producing BoNT X protein variants (e.g., BoNT X protease variants) and methods of using the BoNT X protein variants (e.g., BoNT X protease variants), for example, to induce cell death. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654695 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6489 (20130101) Original (OR) Class C12N 15/64 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287495 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Benjamin L. Miller (Rochester, New York); Jeffrey W. Beard (Rochester, New York) |
| ABSTRACT | The present invention relates to novel devices and methods for viral lysis and isolation as well as a simple, disposable, and nonenzymatic viral load assay based on a hairpin cascade reaction (HCR). |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/572555 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 2200/10 (20130101) B01L 2200/0621 (20130101) B01L 2300/12 (20130101) B01L 2300/087 (20130101) B01L 2300/0681 (20130101) B01L 2300/0819 (20130101) B01L 2300/0874 (20130101) B01L 2300/0877 (20130101) B01L 2300/0887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287503 | Winslow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Monte M. Winslow (Stanford, California); Dmitri Petrov (Stanford, California); Ian P. Winters (Stanford, California); Christopher McFarland (Davis, California); Zoe N. Rogers (Menlo Park, California) |
| ABSTRACT | Compositions and methods are provided for measuring population size for a plurality of clonal cell populations in the same individual, e.g., for measuring tumor size for a plurality of clonally independent tumors within the same individual. A subject method can include: (a) contacting an individual with a plurality of cell markers that are heritable and distinguishable from one another, to generate a plurality of distinguishable lineages of heritably marked cells; (b) after sufficient time has passed for the heritably marked cells to undergo at least one round of division, detecting and measuring quantities of at least two of the plurality of cell markers present in the contacted tissue, thereby generating a set of measured values; and (c) using the set of measured values to calculate the number of heritably marked cells that are present (e.g., for at least two of the distinguishable lineages of heritably marked cells). |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/433015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287507 | Shendure et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Jay Ashok Shendure (Seattle, Washington); Jerrod Joseph Schwartz (Seattle, Washington); Andrew Colin Adey (Seattle, Washington); Cho li Lee (Seattle, Washington); Joseph Brian Hiatt (Seattle, Washington); Jacob Otto Kitzman (Seattle, Washington); Akash Kumar (Seattle, Washington) |
| ABSTRACT | Contiguity information is important to achieving high-quality de novo assembly of mammalian genomes and the haplotype-resolved resequencing of human genomes. The methods described herein pursue cost-effective, massively parallel capture of contiguity information at different scales. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/649435 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287516 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron JOHNSON (Denver, Colorado); Allison SWAIN (Aurora, Colorado); Justin ROBERTS (Denver, Colorado) |
| ABSTRACT | Embodiments of the instant disclosure relate to novel compositions and methods for treating cancer in a subject. In certain embodiments, long noncoding RNAs (lncRNAs) are modified to reduce or eliminate methylation at target nucleotides within the lncRNAs to modulate activities such as tumor promoting activities. In some embodiments, the lncRNAs includes HOTAIR (HOX (homeobox) transcript antisense intergenic RNA) or fragment thereof, where one or more nucleotides are substituted to reduce or eliminate methylation at the one or more nucleotide positions. In certain embodiments, the HOTAIR methylation site includes, but is not limited to, a modification at adenine 783 (A783) of SEQ ID. NO:1 or fragment thereof or equivalent position thereof. In other embodiments, modified lncRNAs disclosed herein can be used to treat a health condition where naturally-occurring lncRNAs have adverse effects. In some embodiments, a composition including modified HOTAIR can be used to treat a subject with cancer. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287530 | IAVARONE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio IAVARONE (Sunny Isles Beach, Florida); Anna LASORELLA (New York, New York) |
| ABSTRACT | The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers. |
| FILED | Friday, March 15, 2024 |
| APPL NO | 18/607341 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/71 (20130101) C07K 14/82 (20130101) C07K 16/18 (20130101) C07K 16/2863 (20130101) C07K 2319/00 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/62 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) G01N 2333/91205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287582 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Je-hyuk Lee (Allston, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts) |
| ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/652923 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287594 | Leong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ka Wai Leong (Boston, Massachusetts); Fangyan Yu (Boston, Massachusetts); Gerassimos Makrigiorgos (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods and compositions for selectively enriching nucleic acid molecules having a target allele sequence within a population of nucleic acid molecules by hybridizing the nucleic acid molecules with an oligonucleotide described herein. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/571545 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6858 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287603 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston system (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Shoujun Xu (Houston, Texas); Qiongzheng Hu (Houston, Texas); Yuhong Wang (Houston, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653029 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 7/52 (20130101) B01L 2200/0663 (20130101) B01L 2300/18 (20130101) B01L 2300/044 (20130101) B01L 2300/0654 (20130101) B01L 2300/0672 (20130101) B01L 2400/0439 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6818 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287609 | Parvez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saba Parvez (Salt Lake City, Utah); Randall T. Peterson (Salt Lake City, Utah); Jing-Ruey Joanna Yeh (Winchester, Massachusetts) |
| ABSTRACT | Disclosed herein are droplets comprising gene editing systems and barcodes. The disclosure further relates to methods for large-scale identification of genes in vivo using barcodes and methods for large-scale identification of gene function in a plurality of subjects using a plurality of droplets. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 18/568690 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2310/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287610 | RABINOWITZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | Natara, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | MATTHEW RABINOWITZ (San Francisco, California); Milena Banjevic (Los Altos Hills, California); Zachary Demko (San Francisco, California); David Johnson (San Francisco, California); Dusan Kijacic (Los Altos Hills, California); Dimitri Petrov (Standford, California); Joshua Sweetkind-Singer (San Jose, California); Jing Xu (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Thursday, April 11, 2024 |
| APPL NO | 18/633282 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6827 (20130101) C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287614 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, EASTERN SHORE (Princess Anne, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bi-Dar Wang (Salisbury, Maryland); Himali Gujrati (Salisbury, Maryland); Siyoung Ha (Salisbury, Maryland) |
| ABSTRACT | The present disclosure relates to the involvement of miR-34a-5p, miR-99b-5p, and miR-96-5p in certain cancers, as well as the use of agonists or antagonists thereof to treat the same. |
| FILED | Wednesday, February 14, 2024 |
| APPL NO | 18/441787 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287627 | Qian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Yong Qian (Cambridge, Massachusetts); Edward S. Boyden (Cambridge, Massachusetts) |
| ABSTRACT | The invention, in some aspects, include methods and systems for temporally multiplexed imaging (TMI). |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588779 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288367 | Perelman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Lev T. Perelman (Brookline, Massachusetts) |
| ABSTRACT | Methods for identifying bacterial species in biofluid samples (e.g., whole blood samples) are described. The methods rely on optical spectroscopy, and enable rapid detection and identification of bacteria directly from whole blood. Not only can LSS-based techniques detect and identify bacteria in biofluids such as whole blood, but that species-level identification can potentially be made based on a small number of bacterial cells, without the need for observing entire colonies or performing susceptibility testing. The methods may comprise illuminating the biofluid sample with input light, detecting scattered light produced by the biofluid sample in response to the illuminating, generating first data indicative of a measured scattering spectrum associated with the biofluid sample using the detected scattered light, and identifying whether at least one of the bacterial species is present in the biofluid sample using the first data. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 18/574571 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/51 (20130101) Original (OR) Class G01N 33/49 (20130101) G01N 2021/4704 (20130101) G01N 2201/0683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288424 | Adler et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as Represented by the Secretary, Department of Health and Humag (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as Represented by the Secretary, Department of Health and Humag (Bethesda, Maryland) |
| INVENTOR(S) | Stephen S. Adler (Chevy Chase, Maryland); Noriko Sato (Potomac, Maryland); Peter Choyke (Rockville, Maryland) |
| ABSTRACT | Methods and apparatus are described for labeling biological particles using acoustophoresis. In a washing stage, two adjacent substreams are passed through a region having a gradient in acoustic energy density, leading to particles being driven from one substream to the other. Washed bioparticles flowing in a medium are accumulated at a trapping site by an acoustic energy barrier while the medium passes by. Accumulated particles are discharged in batches and mixed with labeling particles. The mixture is incubated in a chamber, producing labeled biological particles, which are washed in another washing stage. Processing operations are automated e.g. on a microfluidics platform. Diagnostic and therapeutic applications are disclosed, covering a range of particle types and a range of labeling types. Exemplary biological particles include cells, antibodies, or fragments thereof. Exemplary labeling particles have detection functions (radioligand, magnetic particles, fluorophores), therapeutic functions (drugs), or binding functions (adhesion molecules). |
| FILED | Wednesday, May 11, 2022 |
| APPL NO | 18/290442 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/0652 (20130101) B01L 2300/0663 (20130101) B01L 2300/0864 (20130101) B01L 2400/0436 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288444 | Garfall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Novartis AG (Basel, Switzerland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred Garfall (Wallingford, Pennsylvania); Alex Ganetsky (Philadelphia, Pennsylvania); Saar Gill (Philadelphia, Pennsylvania); Simon Lacey (Media, Pennsylvania); Jan J. Melenhorst (Moreland Hills, Ohio); David Teachey (Rutledge, Pennsylvania); Eric Lancaster (Wynnewood, Pennsylvania); Adam David Cohen (Bala Cynwyd, Pennsylvania); Pamela Shaw (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS). |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/351151 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 35/17 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) G01N 33/6863 (20130101) Original (OR) Class G01N 33/6866 (20130101) G01N 33/6869 (20130101) G01N 33/6893 (20130101) G01N 2800/24 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288450 | DOYLE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the Univerity of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristian DOYLE (Tucson, Arizona) |
| ABSTRACT | The present disclosure relates to methods of determining and administering a treatment course of action. In particular, the present disclosure relates to compositions and methods for monitoring and treating stroke (e.g., with anti-inflammation therapy). |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2333/96491 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288452 | Argun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avni A. Argun (Newton, Massachusetts); Muhit Rana (Southborough, Massachusetts) |
| ABSTRACT | Method and kit for detecting oxytocin in a biological sample. According to one embodiment, the method involves providing a test sample. The test sample is prepared by obtaining a biological sample from one or more subjects and then diluting the biological sample with 1×PBS (phosphate-buffered saline) and 2 mM MgCl2, pH 7.4. The method also involves providing a test cassette. The test cassette includes an electrochemical sensing element and a capture element. The capture element is coupled to the electrochemical sensing element, and the capture element has a binding affinity and specificity for oxytocin. The test sample is then added to the test cassette, whereby at least some of the oxytocin present in the test sample binds to the capture element. Then, the test cassette is electrochemically analyzed for any captured oxytocin, |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590417 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) G01N 27/3277 (20130101) G01N 33/74 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289626 | MAJEWICZ FEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Ann MAJEWICZ FEY (Austin, Texas); Yi ZHENG (Austin, Texas) |
| ABSTRACT | Devices, systems and methods to detect stress using kinematic data are disclosed herein. In certain embodiments a spatial attention mechanism is used to describe the contribution of each kinematic feature to the classification of normal/stressed movements. Some embodiments comprise determining if the kinematic data from a user belong to a class of sub-movements associated with known signatures found to highly correlate with when the user is experiencing motor degradation due to high psychological stress versus a normal class of movements where the user is unaffected by stress. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436313 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 3/0442 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289826 | CRANSHAW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Justin CRANSHAW (Pittsburgh, Pennsylvania); Raz SCHWARTZ (Pittsburgh, Pennsylvania); Jason I. HONG (Pittsburgh, Pennsylvania); Norman SADEH-KONIECPOL (Pittsburgh, Pennsylvania) |
| ABSTRACT | Computer-based systems and methods for discovering neighborhood clusters in a geographic region, where the clusters have a mix of venues and are determined based on venue check-in data. The mix of venues for the clusters may be based on the social similarity between pairs of venues; or emblematic of certain neighborhood typologies; or emblematic of temporal check-in pattern types; or combinations thereof. The neighborhood clusters that are so discovered through venue-check in data could be used for many commercial and civic purposes. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/607995 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290014 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Weiwen Wu (Shenzhen, China PRC); Chuang Niu (Troy, New York) |
| ABSTRACT | In one embodiment, there is provided an apparatus for ultra-low-dose (ULD) computed tomography (CT) reconstruction. The apparatus includes a low dimensional estimation neural network, and a high dimensional refinement neural network. The low dimensional estimation neural network is configured to receive sparse sinogram data, and to reconstruct a low dimensional estimated image based, at least in part, on the sparse sinogram data. The high dimensional refinement neural network is configured to receive the sparse sinogram data and intermediate image data, and to reconstruct a relatively high resolution CT image data. The intermediate image data is related to the low dimensional estimated image. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/569764 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) G06T 11/006 (20130101) Original (OR) Class G06T 2211/421 (20130101) G06T 2211/441 (20230801) G06T 2211/444 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290076 | Hosseinzadeh Taher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Systems, methods, and apparatuses for learning foundation models from anatomy in medical imaging for use with medical image classification and/or image segmentation in the context of medical image analysis. Exemplary systems include means for receiving medical images; extracting human anatomical patterns from the medical images; generating a foundation model via learning the human anatomical patterns from within the medical images received, resulting in generic representations of the human anatomical patterns; wherein the learning includes: first learning prominent objects from within the medical images received corresponding to the human anatomical patterns; and secondly learning detailed parts within the learned prominent objects corresponding to sub-portions of the generic representations of the human anatomical patterns; wherein the learning further includes executing a self-supervised contrastive learning framework, including: executing an anatomy decomposer (AD) of the self-supervised contrastive learning framework which guides the generated foundation model to conserve hierarchical relationships of anatomical structures within the medical images received; and executing a purposive pruner (PP) of the self-supervised contrastive learning framework which forces the model to capture more distinct representations for different anatomical structures at varying granularity levels; and outputting the generated foundation model for use in processing medical images which form no part of the medical images received and used for training the generated foundation model. |
| FILED | Monday, December 04, 2023 |
| APPL NO | 18/528675 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/774 (20220101) Original (OR) Class G06V 20/50 (20220101) G06V 40/10 (20220101) G06V 2201/03 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290416 | Bohmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute for Systems Biology (Seattle, Washington) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington) |
| INVENTOR(S) | Nick Bohmann (Seattle, Washington); Christian Diener (Seattle, Washington); Sean Gibbons (Seattle, Washington) |
| ABSTRACT | Kits, methods, systems and software are provided to predict personalized approaches for increasing butyrate production. Such approaches may include diet and/or supplemental interventions. Simulations may be used to predict—for each of one or more background diet—an extent to which a supplemental intervention may improve predicted butyrate production for an individual (e.g., absolutely or relative to a population corresponding to the diet). Disclosed techniques may then be used to identify one or more select diets/supplemental inventions or to rank or one or more select diets/supplemental inventions for a particular individual. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590897 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290417 | Presse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Steve Presse (Scottsdale, Arizona); Max Schweiger (Phoenix, Arizona); Camile Moyer (Oakland, California); Zeliha Kilic (Memphis, Tennessee) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Steve Presse (Scottsdale, Arizona); Max Schweiger (Phoenix, Arizona); Camile Moyer (Oakland, California); Zeliha Kilic (Memphis, Tennessee) |
| ABSTRACT | A system and associated method learns full distributions over gene states, state connectivities, and associated rate parameters, simultaneously and self-consistently from single molecule level RNA counts within a Bayesian nonparametric paradigm. The method propagates noise originating from fluctuating RNA counts over networks warranted by the data by treating networks themselves as random variables. The method is demonstrated on the lacZ pathway in Escherichia coli cells, the STL1 pathway in Saccharomyces cerevisiae yeast cells, and robustness is verified on synthetic data. |
| FILED | Wednesday, February 07, 2024 |
| APPL NO | 18/435773 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 7/01 (20230101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290433 | Gurcan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Metin Nafi Gurcan (Winston-Salem, North Carolina); Caglar Senaras (Senaras, Netherlands); Gerard Lozanski (West Dublin, Ohio) |
| ABSTRACT | Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653527 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) Computer Systems Based on Specific Computational Models G06N 3/045 (20230101) G06N 3/088 (20130101) G06N 20/20 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290443 | Higgins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. Higgins (Cambridge, Massachusetts); Brody H. Foy (Boston, Massachusetts); Aaron Dominic Aguirre (Boston, Massachusetts); Jonathan C. Carlson (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for generating a trajectory model characterizing a disease state and using the trajectory model in determining a recommended treatment. In one aspect, a method includes obtaining patient data, in which the patient data includes clinical laboratory results of a patient with a disease state; processing the patient data such that the clinical laboratory results are normalized by patient-specific or cohort-specific baseline levels of the clinical laboratory results; and applying a trajectory model to the processed patient data to identify a likelihood of an adverse outcome of the patient, in which the trajectory model characterizes the disease state by a recovery trajectory in a phase-plane of one or more variables. |
| FILED | Thursday, June 16, 2022 |
| APPL NO | 18/571154 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) Original (OR) Class G16H 10/60 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240284901 | Uygun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Korkut Uygun (Boston, Massachusetts); Bote G. Bruinsma (Boston, Massachusetts); Maria-Louisa Izamis (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to organ perfusion systems that can be used at room temperature. The organ perfusion systems do not comprise a temperature controller. In some embodiments, the organ perfusion systems do not comprise a cleaning device for cleaning the perfusion fluid. The perfusion fluid can comprise Williams' medium E. The organ perfusion systems can be portable and can be used to preserving an organ, preventing ischemic damage in an organ, or recovering an ischemically damaged organ. |
| FILED | Thursday, February 01, 2024 |
| APPL NO | 18/430191 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) A01N 1/0247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285016 | Fasel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Army (Natick, Massachusetts) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Army (Natick, Massachusetts) |
| INVENTOR(S) | Benjamin P. Fasel (East Bridgewater, Massachusetts); David S. Colanto (Natick, Massachusetts); Robert V. Dilalla (Walpole, Massachusetts); Tony Kayhart (Cambridge, Massachusetts) |
| ABSTRACT | A functionally graded structure for a protective device includes a plurality of lattice structures including at least a first lattice structure having a first geometry and a second lattice structure having a second geometry. The first lattice structure with the first geometry has a first compression response property and the second lattice structure with the second geometry has a second compression response property that is different from the first compression response property. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/649204 |
| CURRENT CPC | Hats; Head Coverings A42B 3/12 (20130101) A42B 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285233 | Pinsky |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Michael R. Pinsky (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system includes a processor comprising a multivariate predictive model. The multivariate predictive model can be configured to classify responses of a plurality of subjects to a stimulus, predict at least one of a response or an intervention of a target subject to the stimulus based on the classified responses, and adjust a tissue metabolic adequacy of the target subject based on at least one of the predicted response or the predicted intervention of the target subject. The stimulus can include a physical stress, a disease-related stress, a severity of stress, a severity of insult, an external environment condition, or combinations thereof. The tissue metabolic adequacy can be calculated based on a vasomotor tone, a ventricular pump function, an effective circulatory volume, or combinations thereof. |
| FILED | Wednesday, April 03, 2024 |
| APPL NO | 18/625333 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4884 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285360 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. JOHNSON (Medford, Massachusetts); Laura J. BRATTAIN (Lexington, Massachusetts); Brian A. TELFER (Lincoln, Massachusetts); Lars A. GJESTEBY (Maynard, Massachusetts); Joshua S. WERBLIN (Boston, Massachusetts); Nancy D. DELOSA (Westford, Massachusetts); Anthony E. SAMIR (Newton, Massachusetts); Theodore T. PIERCE (Auburndale, Massachusetts) |
| ABSTRACT | A method for remote intervention for a subject includes acquiring an image of a region of interest of the subject using an interventional device positioned on the subject and an image acquisition system. The region of interest includes a target structure and the subject is located at a first site. The method further includes analyzing the acquired image using an image analysis module to identify and label the target structure in the region of interest and transmitting the labelled image from the first site to a second site for expert review. The second site is remote from the first site. The method further includes receiving a command signal at the first site from the second site where the command signal is generated based on the expert review of the labelled image and configured to control an action of the interventional device. In some embodiments, the method may further include analyzing the acquired image to determine a pathway to the vessel that avoids critical structures. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/499179 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/0841 (20130101) A61B 17/3403 (20130101) A61B 34/35 (20160201) Original (OR) Class A61B 2017/3413 (20130101) A61B 2034/303 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285650 | MCCALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ReveraGen BioPharma, Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. MCCALL (Boca Grande, Florida); Eric HOFFMAN (Rockville, Maryland); Kanneboyina NAGARAJU (Highland, Maryland) |
| ABSTRACT | The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-κB for the treatment or prevention of muscular wasting disease, including muscular dystrophy. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/57 (20130101) A61K 31/573 (20130101) Original (OR) Class A61K 31/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) A61P 1/16 (20180101) A61P 3/00 (20180101) Steroids C07J 5/0038 (20130101) C07J 5/0053 (20130101) C07J 5/0076 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285790 | PAZGIER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland); CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (Montreal, Quebec, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marzena PAZGIER (Derwood, Maryland); William D. TOLBERT (North Bethesda, Maryland); Dung N. NGUYEN (Beltsville, Maryland); Andres FINZI (Quebec, Canada); Jonathan RICHARD (Quebec, Canada) |
| ABSTRACT | The present disclosure provides for antibody conjugate molecules (Ab-CD4 conjugates) comprising an antibody, at least one linker, and at least one CD4 compound, wherein the at least one linker links the antibody to the at least one CD4 compound and wherein the Ab-CD4 conjugate is capable of neutralizing an HIV virus, as well as methods of killing HIV-infected cells through an Fc-mediated effector function using the Ab-CD4 conjugates. Also provided are pharmaceutical compositions comprising the Ab-CD4 conjugates and methods of treating or preventing HIV injection in a subject. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/565379 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6811 (20170801) A61K 47/6841 (20170801) Original (OR) Class A61K 47/6889 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285885 | Pasadilla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Paragon Space Development Corporation (Tucson, Arizona); Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Dee Pasadilla (Tucson, Arizona); Peter Francis Readey (Lebanon, Tennessee); Robert Jacobi (Tucson, Arizona); Samuel Zachary Lynn (Somerville, Massachusetts); Judith Lattimer (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides an oxygen delivery and reclamation system that supplies breathable oxygen-enriched gas to one or more users in a chamber. The one or more users receive oxygen at specified oxygen level setpoints. Exhalation air from the one or more users may be purged from the breathing loop using one or both of a recycle pump and an electronically actuated valve. Exhalation air in a purge line and optionally chamber air pulled from the chamber may be recycled using an oxygen concentrator. The oxygen concentrator generates oxygen-enriched gas and oxygen-depleted gas, where the oxygen-enriched gas may be delivered back to one or more users in the chamber. |
| FILED | Thursday, June 30, 2022 |
| APPL NO | 18/574203 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) A61M 16/0009 (20140204) A61M 16/0045 (20130101) Original (OR) Class A61M 16/0057 (20130101) A61M 16/0078 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/202 (20140204) A61M 2016/1025 (20130101) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286151 | HOYE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | Cummins Inc. (Columbus, Indiana); Achates Power, Inc. (San Diego, California) |
| INVENTOR(S) | Robert Earl HOYE (Columbus, Indiana) |
| ABSTRACT | Fluid sprayers for powertrains are disclosed along with methods of manufacturing the fluid sprayers. The fluid sprayers include a unitary body forming a fluid passage therein extending from an inlet at a first end of the body to a nozzle at or near a second end of the body opposite the first end. The fluid sprayers include a mounting portion formed at the first end of the body opposite the second end for connection with a fluid system of the powertrain. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507683 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/20 (20130101) Original (OR) Class B05B 1/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286191 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Powdermet, Inc. (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio) |
| ABSTRACT | A structured three-phase composite which include a metal phase, a ceramic phase, and a gas phase that are arranged to create a composite having low thermal conductivity, having controlled stiffness, and a CTE to reduce thermal stresses in the composite when exposed to cyclic thermal loads. The structured three-phase composite is useful for use in structures such as, but not limited to, heat shields, cryotanks, high speed engine ducts, exhaust-impinged structures, and high speed and reentry aeroshells. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413916 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/1112 (20130101) Original (OR) Class B22F 2003/1106 (20130101) B22F 2998/10 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 5/18 (20130101) B32B 5/20 (20130101) Alloys C22C 1/1084 (20130101) C22C 32/0031 (20130101) C22C 32/0036 (20130101) C22C 32/0078 (20130101) C22C 49/00 (20130101) C22C 49/06 (20130101) C22C 49/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286341 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio); Bingqian Zheng (Miamisburg, Ohio); Hilmar Koerner (Beavercreek, Ohio); Christopher A. Crouse (Waynesville, Ohio) |
| ABSTRACT | A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided. |
| FILED | Wednesday, March 20, 2024 |
| APPL NO | 18/611092 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 64/118 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2079/08 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/3477 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286773 | Humann |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Humann (Los Angeles, California) |
| ABSTRACT | A powered drone tether and deployment system including a plurality of drone coupling/decoupling mechanisms which enable the coupling/decoupling thereto of rechargeable drones in flight. A lead drone may carry the drone tether so as to extend the tether from a base station supplying power thereto such that one or more rechargeable drones may attach to coupling/decoupling mechanisms for charging, and then detach from the coupling/decoupling mechanisms to perform independent flight tasks. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113259 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 3/02 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/60 (20230101) Original (OR) Class B64U 50/35 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286907 | Stein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Stein (Dallas, Texas); Orlando Auciello (Garland, Texas) |
| ABSTRACT | The present disclosure teaches a method of processing chitin, including providing a source of chitin; and pyrolyzing at least a portion of the source of chitin using a microwave plasma. Pyrolyzing includes producing a nanostructured carbon material including at least one of diamond, ultrananocrystalline diamond (UNCD), graphite, and graphene. Pyrolyzing also includes doping the nanostructured carbon material with at least one element selected from the group consisting of nitrogen and boron. Compositions of matter and articles of manufacture are also disclosed. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590318 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 18/20 (20180201) Non-metallic Elements; Compounds Thereof; C01B 32/26 (20170801) Original (OR) Class C01B 32/28 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/60 (20130101) C01P 2006/40 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/16 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/58 (20130101) D06M 11/81 (20130101) D06M 2101/40 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2505/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/587 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287033 | Schiltz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary E. Schiltz (Evanston, Illinois); Daniela Elena Matei (Evanston, Illinois) |
| ABSTRACT | Disclosed herein is a compound, or a pharmaceutically acceptable salt thereof, that has a formula MTG2-L-ME3. MTG2 is a moiety that binds to tissue transglutaminase 2 (TG2), L is a bond or a linker covalently attaching MTG2 and ME3, and ME3 is a moiety that binds to an E3 ubiquitin ligase. Disclosed herein are also the uses of the compound, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same, in a method of treating a disease or disorder associated with TG2 activity or in a method of inhibiting cell proliferation. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/433123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 411/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287050 | Bender et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron M. Bender (Spring Hill, Tennessee); Changho Han (Nashville, Tennessee); Matthew Spock (Nashville, Tennessee); Cori A. Malinky (Nashville, Tennessee); Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee) |
| ABSTRACT | Disclosed are compounds of formula (I) wherein G1 is as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in the treatment of e.g. a neurodegenerative disorder, a movement disorder, or a brain disorder, such as e.g. Parkinson's disease, drug-induced Parkinsonism, dystonia, Tourette's syndrome, dyskinesias, schizophrenia, cognitive deficits associated with schizophrenia, excessive daytime sleepiness, attention deficit hyperactivity disorder (ADHD), Huntington's disease, chorea, cerebral palsy, and progressive supranuclear palsy. An exemplary compound is e.g. (2,5-difluoro-4-(6-(((3aR,5s,6aS)-2- ((tetrahydro-2H-pyran-4-yl)methyl)octahydrocyclopenta[c]pyrrol-5- yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-λ6-sulfanone (e.g. example 12; compound no. 7) Pharmacological data on the activity of the compounds in an mAChR M4 cell-based assay are provided (e.g. table 2) |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/567212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/501 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287054 | Schneekloth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John S. Schneekloth (Frederick, Maryland); Mo Yang (Frederick, Maryland); Xiao Liang (Frederick, Maryland); Christopher Fullenkamp (Frederick, Maryland) |
| ABSTRACT | Small molecule compounds that selectively bind to non-canonical G-quadruplex (G4) structures, such as G4s in DNA found in various types of genes described herein, along with methods of using the compounds to reduce or inhibit protein (e.g., N-Myc protein) expression in cells, such as cancer cells. The compounds have a structure according to formulas described herein, or a stereoisomer, tautomer, or pharmaceutically effective salt or ester thereof. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568738 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/501 (20130101) A61K 31/5377 (20130101) Heterocyclic Compounds C07D 413/04 (20130101) C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287160 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to an antibody cocktail comprising antibodies that bind to and protect subjects again multiple ebolavirus strains and methods for use thereof. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 18/556648 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/52 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287326 | Waller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Gordon H. Waller (Vienna, Virginia); Corey T. Love (Alexandria, Virginia); Rachel E. Carter (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein is a method of discharging a battery by providing a composition having a solution of a crosslinked or crosslinkable polymer and a solvent and conductive carbon particles; and applying the composition to a battery in contact with an anode and a cathode to form an electrical connection from the anode to the cathode. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/585046 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/24 (20130101) Original (OR) Class C09D 7/45 (20180101) C09D 7/61 (20180101) C09D 7/65 (20180101) C09D 7/70 (20180101) C09D 129/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287329 | MARKVICKA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia); VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERITY (Blacksburg, Virginia); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Niger) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric MARKVICKA (Lincoln, Nebraska); Aaron HAAKE (Denton, Nebraska); Michael D. BARTLETT (Blacksburg, Virginia); Ravi Tej Anand TUTIKA (Christiansburg, Virginia); Gwyneth SCHLOER (Blacksburg, Virginia) |
| ABSTRACT | In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods of additive manufacture of emulsion compositions. In various aspects, the present disclosure relates to composite materials incorporating microstructures formed by inclusion compositions, and methods of their manufacture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/573837 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2021/003 (20130101) B29K 2075/00 (20130101) B29K 2083/00 (20130101) B29K 2105/16 (20130101) B29K 2505/00 (20130101) B29K 2869/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/023 (20130101) Original (OR) Class C09D 11/102 (20130101) C09D 11/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287404 | Berkebile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Berkebile (Havre De Grace, Maryland); Harry D. Wise (Buffalo Grove, Illinois); Tobias Vela Martin (Evanston, Illinois); Qian Wang (Evanston, Illinois); Yip-Wah Chung (Wilmette, Illinois); Zaid Ali Subhi Al Hassan (Norridge, Illinois) |
| ABSTRACT | Methods of pre-conditioning and lubricating the rubbing surfaces of steel substrates are provided. The methods include a pre-conditioning step in which a hydrocarbon fluid having cycloalkane carboxylic acid additives dispersed therein is used to form a tribofilm on a rubbing surface of a device, following by replacing the pre-conditioning lubricant with a cycloalkane-carboxylic acid-free hydrocarbon lubricant for the regular operation of the device. The tribofilm formed during the pre-conditioning step provides long-term friction and wear reduction at the rubbing surfaces, even after it is replaced, and allows for the subsequent operation of the device without the need to change the composition of the regularly used lubricant. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507758 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 101/02 (20130101) C10M 129/46 (20130101) Original (OR) Class C10M 2203/1025 (20130101) C10M 2207/121 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2040/246 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287516 | JOHNSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron JOHNSON (Denver, Colorado); Allison SWAIN (Aurora, Colorado); Justin ROBERTS (Denver, Colorado) |
| ABSTRACT | Embodiments of the instant disclosure relate to novel compositions and methods for treating cancer in a subject. In certain embodiments, long noncoding RNAs (lncRNAs) are modified to reduce or eliminate methylation at target nucleotides within the lncRNAs to modulate activities such as tumor promoting activities. In some embodiments, the lncRNAs includes HOTAIR (HOX (homeobox) transcript antisense intergenic RNA) or fragment thereof, where one or more nucleotides are substituted to reduce or eliminate methylation at the one or more nucleotide positions. In certain embodiments, the HOTAIR methylation site includes, but is not limited to, a modification at adenine 783 (A783) of SEQ ID. NO:1 or fragment thereof or equivalent position thereof. In other embodiments, modified lncRNAs disclosed herein can be used to treat a health condition where naturally-occurring lncRNAs have adverse effects. In some embodiments, a composition including modified HOTAIR can be used to treat a subject with cancer. |
| FILED | Friday, November 10, 2023 |
| APPL NO | 18/506637 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287657 | Goswami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ramasis Goswami (Alexandria, Virginia); Alex E. Moser (Fort Washington, Maryland) |
| ABSTRACT | A dual phase high entropy boride-carbide composite for extreme environments, comprising dual phases of high entropy boride (HEB) and high entropy carbide (HEC), wherein the high entropy boride comprises (Zr—Hf—Ti—V)B2 and wherein the high entropy carbide comprises (Zr—Hf—Ti—V)C. A method of making a dual phase high entropy boride-carbide composite for extreme environments, comprising the steps of utilizing a pressureless reactive sintering process, providing a Zr—Hf—Ti—V—B4C powder blend, maintaining a low sintering temperature, allowing the Zr—Hf—Ti—V—B4C powder blend to result in HE-Alloy powder and B4C, allowing the B4C to result in 4B and C and heat, reacting the HE-Alloy powder with the B and the C, and forming a HE-boride composite and a HE-carbide composite, wherein the HE-boride composite and HE-carbide composite comprise (Zr—Hf—Ti—V)B2+(Zr—Hf—Ti—V)C. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443995 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 2009/044 (20130101) Alloys C22C 1/051 (20130101) C22C 29/08 (20130101) Original (OR) Class C22C 29/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240287711 — Conversion of Organic Material to Nanocarbon Structures via Microwave Plasma Pyrolysis
| US 20240287711 | Stein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Stein (Dallas, Texas); Orlando Auciello (Garland, Texas) |
| ABSTRACT | The present disclosure teaches a method of processing chitin, including providing a source of chitin; and pyrolyzing at least a portion of the source of chitin using a microwave plasma. Pyrolyzing includes producing a nanostructured carbon material including at least one of diamond, ultrananocrystalline diamond (UNCD), graphite, and graphene. Compositions of matter and articles of manufacture are also disclosed. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589842 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/17 (20130101) D01F 9/24 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2501/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288089 | SMITH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Huntington Ingalls Incorporated (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles SMITH (Newport News, Virginia); Stephen HOLLOWOOD (Newport News, Virginia) |
| ABSTRACT | A spool valve actuator may include a stop fixed to the case with a cylindrical body member having a first set of slots of a first length at regular circumferential distances and a second set of slots of a second length at regular circumferential distances offset from the first set of slots, both set of slots configured to slidably receive a proximal portion of a positioner, a ratchet member may comprise, a cylindrical body slidably attached to the spool valve shaft and keyed to the stop to prevent relative rotation, a distal edge comprising a plurality of distally facing teeth configured to engage the proximal portion of the positioner when the ratchet is moved away from the stop, the positioner may comprise a plurality of proximally extending positioning members configured to engage with both the distally facing teeth and the slots in the stop. |
| FILED | Friday, October 13, 2023 |
| APPL NO | 18/379977 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 11/0704 (20130101) F16K 31/163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288309 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xueji Wang (West Lafayette, Indiana); Zubin Jacob (West Lafayette, Indiana) |
| ABSTRACT | A tunable hyperspectral-polarimetric filter system includes a first polarizer, a crystal filter and a second polarizer. The first polarizer is configured to transmit light in a first direction of linear polarization. The polarization selection may be substantially the same for all wavelengths at a spectral range of interest. The crystal filter, may be parallelly and coaxially disposed after the first polarizer. The crystal filter is configured to rotates the first direction of linear polarization for light transmitted by the first polarizer, wherein rotation angles differ for different wavelengths at the spectral range of interest. The second polarizer may be parallelly and coaxially disposed after the crystal filter. The second polarizer may substantially transmit a second direction of linear polarization of the light transmitted by the crystal filter. The first polarizer and/or the second polarizer are rotatable to tune for different transmission spectra for spectral and polarimetric imaging resolution. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 18/573375 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0229 (20130101) G01J 3/0237 (20130101) G01J 3/447 (20130101) G01J 3/2823 (20130101) G01J 4/04 (20130101) Original (OR) Class G01J 2003/2826 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288311 | Rhee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jehyuk Rhee (Newbury Park, California); Matthew C. Thomas (Carpinteria, California); Henry Lee (Goleta, California) |
| ABSTRACT | A LADOR circuit is in signal communication with a pixel array. The LADOR circuit is configured to generate an integrator reset voltage based on a resistance of the at least one heated bolometer pixel, and to detect laser energy incident on the at least one heated bolometer pixel based on a comparison between the integrator reset voltage and an input threshold voltage (Vthreshold). |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523391 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/24 (20130101) Original (OR) Class G01J 5/048 (20130101) G01J 2005/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288351 | Kvryan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Armen Kvryan (Glendale, California) |
| ABSTRACT | Provided are apparatus and methods for sensing material degradation through sensing of mass accumulation. In some aspects, the apparatus and methods employ a material such as aerogel in conjunction with a force-sensing device such as a piezoelectric sensor placed in contact with or in proximity to a material under test. Degradation of the material under test is sensed by sensing a change in mass of the aerogel absorbing parts or particles of material lost by the unit under test that, in turn, acts to further place force on or deform the piezoelectric sensor enabling real time measurement of degradation by sensing changes in the output voltage of the piezoelectric sensor. These changes in output voltage may then be correlated to the mass degradation of the unit under test. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588994 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288374 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZYMERON CORPORATION (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guandong ZHANG (Cary, North Carolina); Zhiguo ZHOU (Chapel Hill, North Carolina); Fang LIU (Cary, North Carolina) |
| ABSTRACT | Described herein are compositions and methods for the rapid detection of target analytes on surfaces and in solutions using colorimetric analysis. In some embodiments, the compositions and methods may include plasmonic nanoparticles, a binding receptor conjugated or adsorbed to a surface of the nanoparticles, and a polymer-ligand conjugate. In some embodiments, the target analytes may include one or more opioids. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538408 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288456 | DEJOHN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biomeme, Inc. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc Dominic DEJOHN (Philadelphia, Pennsylvania); Christopher COX (Philadelphia, Pennsylvania); Thomas WELSH (Philadelphia, Pennsylvania); Luke GARY (Philadelphia, Pennsylvania); Alexia QUINN (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing a biological sample may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device. |
| FILED | Tuesday, November 28, 2023 |
| APPL NO | 18/520811 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/02 (20130101) G01N 35/0098 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288504 | O'Hayre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan P. O'Hayre (Golden, Colorado); Jake Dickey Huang (Golden, Colorado) |
| ABSTRACT | An integrated measurement and analysis technique that greatly reduces the time required to measure and analyze electrochemical activity while maintaining high resolution. The order-of-magnitude increase in speed is potentially transformative for electrochemical characterization: it enables new modes of investigation that produce comprehensive images of electrochemical activity, rather than isolated fragments of information. The insight derived from the integrated measurement and analysis techniques of the present disclosure should be invaluable for stimulating innovations towards next-generation energy technologies. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584766 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/389 (20190101) Original (OR) Class G01R 31/392 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288582 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Blackmore Sensors and Analytics, LLC. (Palo Alto, California) |
| ASSIGNEE(S) | Blackmore Sensors and Analytics, LLC. (Palo Alto, California) |
| INVENTOR(S) | Stephen C. Crouch (Palo Alto, California); Randy R. Reibel (Palo Alto, California); James Curry (Palo Alto, California); Trenton Berg (Palo Alto, California) |
| ABSTRACT | Techniques for automatic adaptive scanning with a laser scanner include obtaining range measurements at a coarse angular resolution and forming a horizontally sorted range gate subset and a characteristic range. A fine angular resolution is determined automatically based on the characteristic range and a target spatial resolution. If the fine angular resolution is finer than the coarse angular resolution, then a minimum and maximum vertical angle is automatically determined in each horizontal slice extending a bin size from any previous horizontal slice. A set of adaptive minimum and maximum vertical angles is determined automatically by dilating and interpolating the minimum and maximum vertical angles of all the slices to the second horizontal angular resolution. A horizontal start angle, and the set of adaptive minimum and maximum vertical angles are sent to cause the ranging system to obtain measurements at the second angular resolution. |
| FILED | Tuesday, November 14, 2023 |
| APPL NO | 18/508922 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/18 (20130101) G01S 13/343 (20130101) G01S 13/428 (20130101) G01S 13/526 (20130101) G01S 13/582 (20130101) G01S 17/42 (20130101) Original (OR) Class G01S 17/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288886 | MISTRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| ASSIGNEE(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| INVENTOR(S) | Mital Chandrakant MISTRY (Richmond, Texas); Zachary W. LEUTWYLER (Richmond, Texas); Aaron P. RICHIE (Missouri City, Texas); Manmohan S. KALSI (Houston, Texas) |
| ABSTRACT | A passive thermal control valve comprising a thermal actuator coupled to a valve body having first and second ports. The thermal actuator including an actuator body having an inner bore. An adjustment stop engages the actuator body. A cylinder is received within the actuator body inner bore and the cylinder has a cylinder bore open at one end. An actuator spring within the actuator body biases the cylinder towards the adjustment stop. An actuator rod is at least partially received within the cylinder and has first and second ends. At least a portion of the actuator rod is allowed to extend through the open cylinder bore. A sealing element forms a seal between the actuator rod and the cylinder and defines a sealed chamber within the cylinder. A thermal fluid is contained within the cylinder. A lever mechanism is connected to the valve body and includes a lever having a first end connected to the valve body. A valve spool is connected to a lever second end. The valve spool is arranged and designed to close the first port and allow a system fluid to flow through the second port, close the second port and allow the system fluid to flow through the first port, or allow the system fluid to flow through both the first and second ports. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640268 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/002 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289432 | Vasudevan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Amit Vasudevan (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a system architecture that structures commodity heterogeneous interconnected computing platforms around universal object abstractions, which are a fundamental system abstraction and building block that provides practical and provable end-to-end guarantees of security, correctness, and timeliness for the platform. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623417 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4812 (20130101) G06F 11/3608 (20130101) G06F 21/44 (20130101) Original (OR) Class G06F 21/602 (20130101) G06F 2221/2141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289524 | BARKER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating a superconducting electronic circuit design. The system includes a memory and a processor. The processor simulates a superconducting electronic circuit design using a first process variation to produce a first score and simulates the superconducting electronic circuit design using a second process variation to produce a second score. The processor, in response to determining that the first score is lower than the second score, simulates the superconducting electronic circuit design using the first process variation and a first design variation to produce a third score and simulates the superconducting electronic circuit design using the first process variation and a second design variation to produce a fourth score. The processor updates the superconducting electronic circuit design using the first process variation and the first design variation in response to determining that the third score is higher than the fourth score. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113582 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2119/02 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289589 | Principe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose C. Principe (Gainesville, Florida); Ran Dou (Gainesville, Florida) |
| ABSTRACT | A universal recurrent event memory network system comprising a query block configured to generate one or more query vectors, a key block configured to generate one or more key vectors, a value block configured to generate one or more value vectors, and an external memory comprising a key vector block and a value vector block. The external memory is configured to compare similarity between the one or more query vectors and the one or more key vectors and generate one or more read vectors based at least in part on the comparison and the one or more value vectors. The universal recurrent event memory network system further comprising an output block configured to generate one or more outputs based at least in part on the one or more read vectors and a previous memory state. |
| FILED | Friday, November 03, 2023 |
| APPL NO | 18/501277 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0442 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289665 | Pichler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannes Pichler (Pasadena, California); Harry Jay Levine (Cambridge, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Ahmed Omran (Cambridge, Massachusetts); Alexander Keesling Contreras (Cambridge, Massachusetts); Giulia Semeghini (Cambridge, Massachusetts); Vladan Vuletic (Cambridge, Massachusetts); Markus Greiner (Cambridge, Massachusetts); Tout Wang (Cambridge, Massachusetts); Sepehr Ebadi (Cambridge, Massachusetts) |
| ABSTRACT | A device includes a grouping of N qubits, where N is equal to two or more, and a coherent light source configured to, given selected values for a set of parameters of at least a first and a second laser pulse, the parameters selected from a relative phase shift, a laser frequency, a laser intensity, and a pulse duration: apply at least the first and second laser pulses to all qubits within the grouping of N qubits, thereby coupling a non-interacting quantum state |1 |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573270 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290075 | Yuille et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Yuille (Baltimore, Maryland); Adam Kortylewski (Baltimore, Maryland) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on computer-storage media, used for object detection in an input image that can include at least partial object occlusion. In some implementations, input data representing the image depicting an object can include object-based features and context-based features used for object detection. The feature is processed by a deep convolutional neural network (DCNN) model. First feature data generated by the DCNN is provided to an occlusion model and a generative compositional model. The occlusion model can detect locations where an object depicted in the image is occluded by an object of any other type. The generative compositional model detects the presence of different classes of objects that represent parts or partial components of object depicted in the image. The output of the compositional model and occlusion model is a likelihood map that shows if an object is depicted in the input image. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570325 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/74 (20170101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/40 (20220101) G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/7715 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290509 | HOWE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy M. HOWE (SCOTTSDALE, Arizona); Steven D. HOWE (PHOENIX, Arizona) |
| ABSTRACT | A customizable thin plate fuel form and reactor core therefor are disclosed. The thin plate fuel will comprise a fuel material embedded within a matrix material, with the entire unit having a coating. The thin plate fuel may be flat or curved and will have flow channels formed within at least the top surface of the fuel plate. The structure of the thin plate fuel will make it easier for coating with Tungsten or any other suitable material that will help contain any byproducts, prevent reactions with the working fluid, and potentially provide structural support to the thin plate fuel. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419046 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/20 (20130101) G21C 3/36 (20130101) Original (OR) Class G21C 3/64 (20130101) G21C 3/626 (20130101) G21C 5/16 (20130101) G21C 5/18 (20130101) G21C 5/126 (20130101) G21C 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291003 | PLUMLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); U.S. GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (Kirtland AFB, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Bryan PLUMLEY (Albuquerque, New Mexico); Lok-kun TSUI (Albuquerque, New Mexico); Thomas Liang-Shi PENG (Kirtland AFB, New Mexico); Fernando GARZON (Santa Fe, New Mexico) |
| ABSTRACT | An integrated fuel cell and combustion system that integrate both a fuel cell and a combustion system, such that the fuel cell and the combustion system share a a fuel source and an oxidizer source, and the fuel cell and combustion system can be utilized singularly or simultaneously based on the needs for power generation. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585788 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/28 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9033 (20130101) H01M 8/004 (20130101) H01M 8/1253 (20130101) H01M 8/2425 (20130101) H01M 8/04022 (20130101) H01M 8/04201 (20130101) Original (OR) Class H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291408 | Fairall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wright Electric Inc. (Ballston Spa, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Earl Fairall (Ballston Spa, New York); Jeffrey M. Engler (Ballston Spa, New York); David Laselle (Ballston Spa, New York); Subhashree Rajagopal (Ballston Spa, New York) |
| ABSTRACT | A portable generator has an electric machine and a prime mover to rotate the electric machine. The portable generator has a power converter to receive power from the electric machine, convert the received power, and output the converted power. The portable generator has a housing to enclose the electric machine, the prime mover, and the power converter. The portable generator has a control system. The control system operates the power converter to output the converted power at a power rating of at least 600 kW. The control system then determines an output power demand and determines a rotational speed target after determining the output power demand. The control system then reduces a rotational speed of the electrical machine using the power converter after determining the rotational speed target. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/586243 |
| CURRENT CPC | Dynamo-electric Machines H02K 5/04 (20130101) H02K 11/33 (20160101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 9/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291558 | Kassas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak Kassas (Columbus, Ohio); Mohammad NEINAVAIE (Irvine, California); Joe Khalife (Irvine, California) |
| ABSTRACT | Processes and device configurations are provided for extracting navigation observables and navigation using low earth orbit (LEO) signals. Methods and systems described herein can detect one or more low earth orbit (LEO) satellite downlink signals, and determine carrier phase observables and Doppler observables from the downlink signals in order to determine position estimates. Processes can include determining at least one carrier phase observable from the one or more LEO satellite downlink signals, wherein determining the at least at least one carrier phase observable includes tracking a modified beat carrier phase of a sample of a detected LEO signal by performing an estimation operation for a time period and adaptive updating of measurement noise. Processes can include use of position estimates for navigation and navigation based on carrier phase tracking. Processes are also provided for determination of satellite synchronization signals (SS) from downlink transmissions using subspace detection. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570319 |
| CURRENT CPC | Transmission H04B 7/195 (20130101) H04B 7/1855 (20130101) Original (OR) Class H04B 7/18589 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291573 | Caliga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ColdQuanta, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Charles Caliga (Lafayette, Colorado); Haoquan Fan (Erie, Colorado); Eric Magnuson Bottomley (Broomfield, Colorado) |
| ABSTRACT | A radio-frequency receiver achieves high sensitivity by pumping atoms to high-azimuthal ( |
| FILED | Tuesday, October 10, 2023 |
| APPL NO | 18/378591 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Transmission H04B 10/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291688 | COFFIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fuse Integration, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerome V. COFFIN (San Diego, California); Ryan GILLESPIE (San Diego, California); Charles Arthur LOACH (San Diego, California); Frank Dell KRONEWITTER, III (San Diego, California) |
| ABSTRACT | Military Standard 1553 (MIL-STD-1553) is a military standard that was published by the United States Department of Defense in 1973 for tactical aircraft. Despite advances in communications, many machines retain MIL-STD-1553 buses, since retrofitting the machines with newer communication systems is not always practical. However, newer subsystems for such machines tend to utilize Internet Protocol (IP) for higher bandwidth communications. Accordingly, a device is disclosed that enables IP communications over existing MIL-STD-1553 buses. This enables an existing MIL-STD-1553 bus to span the gap between two separate IP networks (e.g., subsystems) within the machine. In addition, the IP communications may utilize Standard Agreement (STANAG) 7221 to provide higher bandwidth over the existing MIL-STD-1553 buses. For added security, the IP communications may also be encrypted during transport over the MIL-STD-1553 buses. |
| FILED | Tuesday, November 07, 2023 |
| APPL NO | 18/387720 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/4013 (20130101) Original (OR) Class H04L 63/0485 (20130101) H04L 69/08 (20130101) H04L 2012/4028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292078 | Al-Husseini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahdi Al-Husseini (Enterprise, Alabama); Joshua L. Barnett (Standord, California); Anthony Chen (Stanford, California) |
| ABSTRACT | A motorized cross-polarizer instrument for providing strategic cross-polarization is provided. In one exemplary embodiment, the instrument includes outer and inner housings. A polarizer, mounted inside the inner housing, permits rotation of the polarizer in tandem with the inner housing. A capstan, mounted inside the outer housing, permits rotation of the inner hosing relative to the outer housing. And a motor, connected to the capstan, rotates the inner housing. The instrument may be located on or place over a polarized digital display unit that includes a polarizer film thus forming a display system for providing strategic cross-polarization. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584890 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/281 (20130101) Image Data Processing or Generation, in General G06T 7/13 (20170101) Pictorial Communication, e.g Television H04N 23/51 (20230101) H04N 23/53 (20230101) H04N 23/55 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292568 | Andrade et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (San Diego, California) |
| INVENTOR(S) | Marcio Calixto de Andrade (San Diego, California); Susan A. E. Breggren (San Diego, California); Anna Leese de Escobar (Encinitas, California); James J. Collins (San Diego, California); Mark Flemon (Lakeside, California); Michael O'Brien (San Diego, California) |
| ABSTRACT | A cryogenic platform includes a motor, a computer processor, and a vacuum chamber with a high temperature stage and a low temperature stage. The motor is attached to a cryocooler. The computer processor is connected via one or more connections through one or more feedthrough ports to one or more electronic devices. The vacuum chamber encloses the high temperature stage and the low temperature stage, where the high temperature stage and low temperature stage are attached to the motor via a temperature stage attachment. |
| FILED | Monday, February 27, 2023 |
| APPL NO | 18/174758 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 19/006 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20372 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240284863 | Nuzhdin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Nuzhdin (Los Angeles, California); Melisa Osborne (Los Angeles, California); Gary Molano (Los Angeles, California); Bernadeth Tolentino (Los Angeles, California) |
| ABSTRACT | This disclosure describes the microbial network and community assembly patterns of brown macro algae, e.g., Macrocystis pyrifera gametophyte germplasm, cultures used to cultivate an offshore farm and identify network features associated with increased biomass of mature sporophytes. Several network features, such as clustering coefficient and edge ratios, significantly vary with biomass outcomes; also, gametophytes that become low- or high biomass sporophytes have different hub taxa. This disclosure describes microbial community dynamics in M. pyrifera germplasm cultures and development of early life stage inoculants used on seaweed cultivars to increase biomass yield. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589339 |
| CURRENT CPC | Harvesting; Mowing A01D 44/00 (20130101) Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 13/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286095 | SOBECKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER A. SOBECKI (AIKEN, South Carolina); KAI HAN (EVANS, Georgia) |
| ABSTRACT | In one aspect, a system for dispersing particles in a fluid of a fluid container includes one or more permanent magnets, one or more electric coils, and/or one or more electrodes. The one or more permanent magnets, one or more electric coils, and/or one or more electrodes are configured to disperse the particles in the fluid of the fluid container. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/174002 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 23/56 (20220101) B01F 23/59 (20220101) B01F 33/451 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286113 | Tezcan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Faik Tezcan (La Jolla, California); Jake Bailey (La Jolla, California); Ling Zhang (La Jolla, California) |
| ABSTRACT | Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals-which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals. Some example embodiments combine the properties of hydrogels (flexibility, adaptability, elasticity, self-healing), crystals (structural order) and proteins (chemical and genetic tailorability). |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/655056 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) B01J 20/261 (20130101) Original (OR) Class B01J 20/345 (20130101) B01J 20/3425 (20130101) B01J 20/28047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286123 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, Michigan) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Sangwoo LEE (Cooes, New York); Chulsung BAE (Cohoes, New York); Carrie Lynn TRANT (Troy, New York) |
| ABSTRACT | An anion exchange membrane is composed of a copolymer of 1,1-diphenylethylene and one or more styrene monomers, such as 4-tert-butylstyrene. The copolymer includes a backbone substituted with a plurality of ionic groups coupled to phenyl groups on the backbone via hydrocarbyl tethers between about 1 and about 7 carbons in length. High-temperature conditions enabled by these copolymers enhance conductivity performance, making them particularly suitable for use in anion exchange membranes in fuel cells, electrolyzers employing hydrogen, ion separations, etc. The properties of the membranes can be tuned via the degree of functionalization of the phenyl groups and selection of the functional groups, such as quaternary ammonium groups. Several processes can be used to incorporate the desired ionic functional groups into the polymers, such as chloromethylation, radical bromination, Friedel-Crafts acylation and alkylation, sulfonation followed by amination, or combinations thereof. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/607624 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/14 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 212/32 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) C08J 2325/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286183 | Komarasamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mageshwari Komarasamy (Richland, Washington); Scott A. Whalen (West Richland, Washington); Glenn J. Grant (Benton City, Washington); Brandon Scott Tayson (West Richland, Washington) |
| ABSTRACT | A method for shear-assisted extrusion of a billet or feedstock can involve extruding a first portion of the feedstock through a die opening while rotating the die face relative to the feedstock at a first rotational rate and applying a first axial extrusion force. A second portion of the feedstock can be extruded through the opening while rotating the die face at a second rotational rate and applying a second axial extrusion force. This can establish different temperature ranges at the interface for each portion, resulting in a first extruded portion with different physical properties than the second extruded portion. |
| FILED | Friday, November 17, 2023 |
| APPL NO | 18/513402 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) B21C 23/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286361 | MORAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); 3D SYSTEMS, INC. (Rock Hill, South Carolina) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); 3D SYSTEMS, INC. (Rock Hill, South Carolina) |
| INVENTOR(S) | Bryan D. MORAN (Livermore, California); Brian J. BAUMAN (Livermore, California); Matthew Kenneth GELBER (Houston, Texas); Jordan MILLER (Houston, Texas) |
| ABSTRACT | Provided herein is a system for producing a product. The system generally comprises a large-area micro-stereolithography system, an optical imaging system, and a controller in communication with the large-area micro-stereolithography system and the optical imaging system. The large-area micro-stereolithography system is capable of generating the product by optically polymerizing successive layers of a curable resin at a build plane. The controller is capable of analyzing a focus level of the reference target based on the captured image; and based on the analyzing, adjusting a focus property of the projected image beam of the stereolithography system. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653754 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287240 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (San Leandro, California); Michael Keith Hearon (College Station, Texas); Jane P. Bearinger (Berwyn, Pennsylvania) |
| ABSTRACT | This invention relates to chemical polymer compositions, methods of synthesis, and fabrication methods for devices regarding polymers capable of displaying shape memory behavior (SMPs) and which can first be polymerized to a linear or branched polymeric structure, having thermoplastic properties, subsequently processed into a device through processes typical of polymer melts, solutions, and dispersions and then crossed linked to a shape memory thermoset polymer retaining the processed shape. |
| FILED | Tuesday, April 09, 2024 |
| APPL NO | 18/630394 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 45/0001 (20130101) B29C 48/00 (20190201) B29C 48/03 (20190201) B29C 51/00 (20130101) B29C 51/002 (20130101) B29C 61/06 (20130101) B29C 67/20 (20130101) B29C 71/02 (20130101) B29C 71/04 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/73 (20130101) C08G 18/83 (20130101) C08G 18/673 (20130101) C08G 18/675 (20130101) C08G 18/722 (20130101) C08G 18/758 (20130101) C08G 18/3206 (20130101) Original (OR) Class C08G 63/52 (20130101) C08G 2101/00 (20130101) C08G 2280/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287390 | Zacher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan H. Zacher (Pasco, Washington); Lisa A. Smith-Middleton (Pasco, Washington); Todd R. Hart (Kennewick, Washington); Andrew J. Schmidt (Richland, Washington); Michael R. Thorson (Richland, Washington); Samuel P. Fox (West Richland, Washington); Dylan J. Cronin (Richland, Washington) |
| ABSTRACT | A process where a liquid or supercritical CO2 co-solvent is used in a hydrothermal liquefaction (HTL) process. The process improves yield of the HTL process. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/434609 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 4/007 (20130101) B01J 8/085 (20130101) B01J 8/087 (20130101) B01J 2204/002 (20130101) B01J 2208/00168 (20130101) B01J 2208/00752 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 11/18 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/40 (20130101) Original (OR) Class C10G 2300/1003 (20130101) C10G 2300/1014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287426 | LIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | YuPo J. LIN (Naperville, Illinois); Thomas LIPPERT (Woodridge, Illinois) |
| ABSTRACT | A system and apparatus for biomethanation and removing carbon dioxide from the methane comprises (a) a primary anaerobic digester adapted and arranged to generate a biogas mixture comprising methane and carbon dioxide from organic materials; (b) an electrochemical reactor adapted and arranged to capture carbon dioxide from the biogas as bicarbonate and to generate hydrogen by electrolytic water slitting, and (c) a biomethanation reactor adapted and arranged to convert the bicarbonate and hydrogen from the electrochemical reactor to methane. The electrochemical reactor also acidifies a saline process stream from the biomethanation reactor and returns the acidified process stream back into the biomethanation reactor for pH control in the biomethanation process. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586922 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/005 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/04 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 9/19 (20210101) C25B 9/73 (20210101) C25B 11/031 (20210101) C25B 11/046 (20210101) C25B 15/087 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287549 | Lam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Felix Lam (Cambridge, Massachusetts); Gregory Stephanopoulos (Winchester, Massachusetts); Gerald Fink (Chestnut Hill, Massachusetts) |
| ABSTRACT | The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of biofuels and bioplastics from toxic feedstocks. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/572167 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class Enzymes C12Y 101/01028 (20130101) C12Y 101/01283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287652 | MEDINA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sujeily Soto MEDINA (Gainesville, Florida); Michele V. MANUEL (Gainesville, Florida); Richard HENNIG (Gainesville, Florida); Lilong ZHU (Gainesville, Florida); Biswas RIJAL (Gainesville, Florida) |
| ABSTRACT | Described herein are approaches to stabilizing AlFeSi ternary intermetallic compounds while destabilizing competing phases. The inclusion of metals such as Mn, Ni, Co, Cu, or Zn to produce quaternary systems accomplishes this problem associated with AlFeSi ternary intermetallic compounds. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/497345 |
| CURRENT CPC | Alloys C22C 21/00 (20130101) Original (OR) Class Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288382 | Stevenson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garrett Allan Stevenson (Livermore, California) |
| ABSTRACT | A system for characterizing an object that includes an inedible exterior portion and a potentially edible interior portion comprises a computer system and a plurality of sensors configured to acquire data concurrently about the object. The plurality of sensors include a radar system configured to transmit a radar beam to irradiate the object, and to detect a return signal of the radar beam. The computer system is configured to form a radar image of the interior portion of the object based on the return signal, and to characterizing the object based on the acquired data, by applying a machine learning algorithm to the radar image. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115735 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/02 (20130101) Original (OR) Class G01N 33/02 (20130101) Image Data Processing or Generation, in General G06T 7/0004 (20130101) G06T 2207/10012 (20130101) G06T 2207/10048 (20130101) G06T 2207/20081 (20130101) G06T 2207/30128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288467 | Ziatdinov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Maxim A. Ziatdinov (Oak Ridge, Tennessee); Kevin Roccapriore (Oak Ridge, Tennessee); Yongtao Liu (Oak Ridge, Tennessee); Kyle P. Kelley (Oak Ridge, Tennessee); Rama K. Vasudevan (Oak Ridge, Tennessee); Jacob D. Hinkle (Oak Ridge, Tennessee); Sergei V. Kalinin (Knoxville, Tennessee) |
| ABSTRACT | Systems are provided for machine learning-driven operation of instrumentation with human in the loop. The systems use a model with learnt model parameters to define points for physical-characteristic measurements once the model is trained. The systems use active learning, which considers selection, reinforcement and/or adjustment inputs from the instrumentation's user, to enable describing a relationship between local features of sample-surface structure shown in image patches and determined representations of physical-characteristic measurements. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/655038 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/10 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 21/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288504 | O'Hayre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan P. O'Hayre (Golden, Colorado); Jake Dickey Huang (Golden, Colorado) |
| ABSTRACT | An integrated measurement and analysis technique that greatly reduces the time required to measure and analyze electrochemical activity while maintaining high resolution. The order-of-magnitude increase in speed is potentially transformative for electrochemical characterization: it enables new modes of investigation that produce comprehensive images of electrochemical activity, rather than isolated fragments of information. The insight derived from the integrated measurement and analysis techniques of the present disclosure should be invaluable for stimulating innovations towards next-generation energy technologies. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584766 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) G01R 31/389 (20190101) Original (OR) Class G01R 31/392 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288507 | KHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Faisal Habib KHAN (Littleton, Colorado); MD Sarwar ISLAM (Lakewood, Colorado); Joshua John MAJOR (Kittredge, Colorado); Shuofeng ZHAO (Golden, Colorado) |
| ABSTRACT | A power module that receives a control signal over a wireless connection with the power module using the control signal to generate a driving signal that drives one or more power switches is described. An aging detection feature for a power module is also described. The aging detection feature may employ a level searching circuit and a pulse counting technique that provides information about the state of health of one or more power switches. The information may include estimated values for on-state resistance and/or threshold voltage of one or more power switches. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585497 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/40 (20130101) Original (OR) Class G01R 31/327 (20130101) G01R 31/2621 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/80 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/158 (20130101) Pulse Technique H03K 17/687 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290513 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SHINE Technologies, LLC (Janesville, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Johnson (Janesville, Wisconsin); Abdul Momen (Janesville, Wisconsin); Marek Piechowicz (Beloit, Wisconsin); Riley McSweeny (Milton, Wisconsin) |
| ABSTRACT | A method of radionuclide waste extraction includes directing a waste stream from an upstream segment of a main waste pathway into a waste stream input of an anion exchange column, wherein the waste stream comprises uranium and a target radionuclide, the anion exchange column houses an anion exchange resin, a cation exchange column housing a cation exchange resin is fluidly coupled to the anion exchange column downstream the anion exchange column, and a sluicing preparation tank is fluidly coupled to the anion exchange column. The method further includes adsorbing uranium from the waste stream onto an anion exchange resin, directing the waste stream from the anion exchange column into the cation exchange column, adsorbing the radionuclide onto the cation exchange resin, removing spent anion exchange resin from the anion exchange column, and directing fresh anion exchange resin from the sluicing preparation tank into the anion exchange column. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115599 |
| CURRENT CPC | Separation B01D 15/203 (20130101) B01D 15/362 (20130101) B01D 15/363 (20130101) B01D 15/1871 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 9/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290514 | SOBECKI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE SAVANNAH RIVER ALLIANCE, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER A. SOBECKI (AIKEN, South Carolina) |
| ABSTRACT | In one aspect, a microfluidic device, system, and method for separating and purifying radioisotopes is disclosed. The microfluidic device may comprise an inlet channel stream, an outlet channel stream, and a junction. The inlet channel stream, the outlet channel stream, and the junction may be in fluid communication. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588293 |
| CURRENT CPC | Separation B01D 59/24 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290538 | Kesler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Kesler (Oak Ridge, Tennessee); Michael A. Mcguire (Oak Ridge, Tennessee); Zack Tener (Oak Ridge, Tennessee); Matthew J. Kramer (Swoope, Virginia); Xubo Liu (Ames, Iowa); Cajetan Ikenna Nlebedim (Ames, Iowa) |
| ABSTRACT | A method of increasing anisotropy of magnetic materials formed by a hydrogenation-disproportionation-desorption-recombination (HDDR) process is provided. The method includes subjecting a starting magnetic material to a hydrogenation-disproportionation (HD) step in the presence of a magnetic field to obtain intermediate materials. The strength of the applied magnetic field is between 0.25 T and 9 T, optionally less than or equal to 2 T. The HD step may be performed for a period of time between 10 and 60 minutes at a temperature of at least 600° C., optionally in the range of 600° C. to 900° C. Subsequently, the intermediate materials are subjected to a desorption-recombination (DR) step to obtain a magnetic powder. Application of the magnetic field during the hydrogenation-disproportionation step increases the magnetic anisotropy of the obtained magnetic powder. Magnetic powders obtained by the method and bonded magnets formed with the magnetic powders are also provided. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585633 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/04 (20130101) B22F 9/023 (20130101) B22F 2201/10 (20130101) B22F 2202/05 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/0573 (20130101) H01F 41/0273 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290539 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping WANG (Shoreview, Minnesota); YanFeng JIANG (Berkeley, California) |
| ABSTRACT | Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an applied magnetic field to form a workpiece including at least one iron-based phase domain including uniaxial magnetic anisotropy, wherein the applied magnetic field has a strength of at least about 0.01 Tesla (T). Also disclosed are workpieces made by such methods, apparatus for making such workpieces and bulk materials made by such methods. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/642092 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 27/02 (20130101) Alloys C22C 38/001 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/06 (20130101) H01F 1/08 (20130101) H01F 1/047 (20130101) H01F 41/0266 (20130101) H01F 41/0273 (20130101) Original (OR) Class Dynamo-electric Machines H02K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290937 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Zhu (Newton, Massachusetts); Ying Wang (Boston, Massachusetts) |
| ABSTRACT | Reduction in the tortuosity of electrodes is a favored strategy to enhance the fast-charging capability of lithium-ion batteries by optimizing the ion-transfer kinetics. A facile, low-cost, highly controllable, and high-output continual additive manufacturing roll-to-roll screen printing technology is disclosed herein to render customized vertical channels within electrodes. High-accuracy vertical channels were fabricated by applying as-developed inks, using LiNi0.6Mn0.2Co0.2O2, for example, as the cathode material. The optimized screen-printed electrode exhibited a seven-fold higher specific charge capacity (72 mAh/g) at a current rate of 6 C and superior stability compared with that of the conventional bar-coated electrode (10 mAh/g, 6 C) at a mass loading of 10 mg/cm2. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589258 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/0404 (20130101) H01M 4/0414 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 4/1391 (20130101) H01M 2004/021 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290965 | Counihan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael J. Counihan (Downers Grove, Illinois); Sanja Tepavcevic (Chicago, Illinois); Pallab Barai (Bolingbrook, Illinois); Venkat Srinivasan (Naperville, Illinois); Anil U. Mane (Naperville, Illinois); Rajesh Pathak (Westmont, Illinois); Jeffrey W. Elam (Elmhurst, Illinois) |
| ABSTRACT | A discharged electrochemical cell as described herein comprises an electrochemically reactive metal-containing cathode (e.g., Li, Na, Mg, or Zn; preferably Li) and a layered anode with an electrolyte therebetween. The layered anode comprises a conductive substrate and a reactive film of a metal, a semimetal, a metal oxide, or a semimetal oxide on the surface of the substrate. The reactive film is capable of reversibly alloying with, reversibly forming a mixed phase with, or reversibly reacting with, metal from cathode during charging of cell, and releasing the metal back to the cathode during discharge of the cell. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/437163 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290992 | Tian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on Behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanchen Tian (Morgantown, West Virginia); Wenyuan Li (Morgantown, West Virginia); Xingbo Liu (Morgantown, West Virginia) |
| ABSTRACT | In one aspect, the disclosure relates to conformal coating scaffold electrodes having a sintered porous perovskite scaffold and a continuous, uniform catalyst coating covering the scaffold. In one aspect the perovskite can have the formula BaZrxCeyYzYb(1−x−y−z)O3−δ, wherein 0.1≤x≤0.8, wherein 0≤y≤0.8, and wherein 0≤z≤0.3, while the catalyst can have the formula Pr2−xBaxNiO4+δ, wherein 0≤x≤0.4 (PBNO). The disclosed electrodes exhibit improved long-term operational stability compared to current technology and are sustainable, scalable, and inexpensive to produce. Also disclosed are methods for making the coating, electrochemical cells comprising the electrodes, and devices incorporating the electrochemical cells. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/586661 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8621 (20130101) H01M 4/8657 (20130101) H01M 4/9033 (20130101) Original (OR) Class H01M 8/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291073 | Beck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Alfred Beck (Livermore, California); Sarah Baker (Dublin, California); Jonathan Tesner Davis (Oakland, California); Eric Duoss (Dublin, California); Daniel Tortorelli (Champaign, Illinois); Seth Evan Watts (Collingswood, New Jersey); Marcus A. Worsley (Hayward, California) |
| ABSTRACT | Electrochemical reactors with electrodes that have variable porosity across the electrode and associated methods are described. The electrodes are designed and micro-architected to have variable porosity and 3D flow. One example method of selecting porosities in an electrochemical reactor includes dividing an electrode of the electrochemical reactor into a plurality of unit cells and determining a plurality of cell-specific porosities for the plurality of unit cells as a function of a location for each of the plurality of unit cells. The cell-specific porosities are configured based on a rod diameter of each unit cell's internal structure relative to each unit cell's cell length, and each location in the electrode provides a selected fluid flow property and a selected conductive property to meet one or more performance metrics. |
| FILED | Wednesday, May 01, 2024 |
| APPL NO | 18/652224 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) C25B 9/15 (20210101) C25B 9/70 (20210101) C25B 11/032 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/04 (20130101) H01M 4/88 (20130101) H01M 4/861 (20130101) H01M 4/8605 (20130101) H01M 8/18 (20130101) H01M 10/6561 (20150401) H01M 10/6568 (20150401) Original (OR) Class H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291100 | Helms et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Helms (Oakland, California); Junhua Song (Oakland, California); Michael Baird (Oakland, California); Youngmin Ko (Oakland, California) |
| ABSTRACT | Microporous polymers, materials for making microporous polymers, and electrochemical cells, including anode-free electrochemical cells containing locally concentrated electrolytes, are described. Further provided is an electrochemical cell comprising an anode or a current collector, a first electrolyte, a polymer membrane separator, a second electrolyte, and a cathode, wherein: the polymer membrane separator is positioned between the anode and the cathode: the first electrolyte is in contact with the anode and a first face of the polymer membrane separator; the second electrolyte is in contact with the cathode and a second face of polymer membrane the separator. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 18/289541 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/583 (20130101) H01M 4/662 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 50/414 (20210101) Original (OR) Class H01M 50/491 (20210101) H01M 2004/027 (20130101) H01M 2004/028 (20130101) H01M 2300/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291274 | Hedman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mojdeh Hedman (Tempe, Arizona); Zahra Soltani (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Mojdeh Hedman (Tempe, Arizona); Zahra Soltani (Tempe, Arizona) |
| ABSTRACT | A system and associated method models behavior of an unbalanced distribution system using a current-voltage (IVACOPF) formulation. Untransposed distribution lines, shunt elements of distribution lines, and detailed representation of distribution transformers and DERs are modeled. The system provides detailed modeling of distribution system including mutual impedances, shunt elements, 3-phase to 1-phase lines. The model has multiple applications for distribution system management, planning, and operation. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432332 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/001 (20200101) H02J 3/16 (20130101) Original (OR) Class H02J 3/38 (20130101) H02J 2203/20 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291374 | Galigekere Nagabhushana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veda Prakash Galigekere Nagabhushana (Knoxville, Tennessee); Jason L. Pries (Oak Ridge, Tennessee); Emre Gurpinar (Knoxville, Tennessee); Md Shajjad Chowdhury (Knoxville, Tennessee) |
| ABSTRACT | An inverter circuit is provided to substantially mitigate parasitic ringing and to enable fast switching under high power conditions. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588785 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/22 (20190201) B60L 53/122 (20190201) B60L 2210/40 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/10 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/44 (20130101) H02M 1/0054 (20210501) Original (OR) Class H02M 7/537 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291722 | ROS-GIRALT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reservoir Labs, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordi ROS-GIRALT (Vilafranca del Penedes, Spain); Noah AMSEL (New York, New York); Richard LETHIN (Bronxville, New York) |
| ABSTRACT | A network is designed based on its topology and the expected flow patterns in the network. The use of the latter can lead to efficient use of network resources and can reduce or even minimize waste. Non-interference properties of the expected flows can yield an improved or even optimal design. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653829 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/145 (20130101) Original (OR) Class H04L 47/127 (20130101) H04L 49/1515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291859 | Suryanarayana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ABB Schweiz AG (Baden, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harish Suryanarayana (Apex, North Carolina); David Lee Coats (Bellevue, Washington) |
| ABSTRACT | In one aspect, a controller for detecting erroneous data generated at an electric vehicle charging station (EVCS) is provided. The EVCS includes a plurality of electric vehicle supply equipment (EVSE) for charging electric vehicles. The controller is configured to store a plurality of data models that predict a current at a point of common coupling (PCC) drawn by the EVCS from a utility, where each of the plurality of data models ignores measurements from a different one of the plurality of EVSEs, generate a plurality of predicted current values, each generated using a different one of plurality of data models, measure an actual current value at the PCC, calculate a plurality of difference values, each comprising a difference between one of the predicted current values and the actual current value, and determine whether the erroneous data is being generated based on the plurality of difference values. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/176087 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/62 (20190201) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1466 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292531 | Zinn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kuprion Inc. (Waterbury, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred A. Zinn (Palo Alto, California); Khanh Nguyen (San Jose, California) |
| ABSTRACT | Printed circuit boards may be formed using ceramic substrates with high thermal conductivity to facilitate heat dissipation. Metal nanoparticles, such as copper nanoparticles, may be used to form conductive traces and fill through-plane vias upon the ceramic substrates. Multi-layer printed circuit boards may comprise two or more ceramic substrates adhered together, wherein each ceramic substrate has one or more conductive traces defined thereon and the one or more conductive traces are formed through consolidation of metal nanoparticles. The one or more conductive traces in a first ceramic substrate layer are in electrical communication with at least one second ceramic substrate layer adjacent thereto. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/657931 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) H05K 1/115 (20130101) H05K 1/181 (20130101) H05K 1/183 (20130101) H05K 1/0306 (20130101) Original (OR) Class H05K 3/46 (20130101) H05K 3/107 (20130101) H05K 3/303 (20130101) H05K 3/4038 (20130101) H05K 2201/09227 (20130101) H05K 2201/09563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292638 | Hack et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Universal Display Corporation (Ewing, New Jersey); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Hack (Carmel, California); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A transparent organic photovoltaic cell comprises first and second electrodes, and an active layer between the electrodes, comprising a combination of donor and acceptor molecules which are configured absorb light in one or more sub-spectral ranges within a total spectral range of 400 nm to 2000 nm, wherein the photovoltaic cell is configured to be placed in optical communication with a plants such that at least a portion of light not absorbed by the photovoltaic cells is transmitted to the plant. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/590297 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) H02S 30/20 (20141201) Organic electric solid-state devices H10K 30/10 (20230201) H10K 30/50 (20230201) Original (OR) Class H10K 30/87 (20230201) H10K 39/10 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292734 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Jongchan Kim (Ann Arbor, Michigan) |
| ABSTRACT | An organic light emitting device (OLED) comprises an anode; a cathode; and a light emitting layer, disposed between the anode and the cathode; wherein the light emitting layer comprises at least one luminescent compound; and wherein the transition dipole moment of the at least one luminescent compound is oriented parallel to the surface of the light emitting layer. A method of fabricating a light emitting layer, comprises the steps of providing a substrate; depositing less than 2 nm of a template material on the substrate; and depositing a composition comprising at least one light emitting compound on the template material. |
| FILED | Wednesday, April 10, 2024 |
| APPL NO | 18/631472 |
| CURRENT CPC | Organic electric solid-state devices H10K 30/353 (20230201) H10K 71/164 (20230201) H10K 85/346 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292753 | Dunand et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); Battelle Energy Allliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. Dunand (Evanston, Illinois); Donna P. Guillen (Idaho Falls, Idaho); Alexander Ernst Ludwig Proschel (Chicago, Illinois); Dennis S. Tucker (Idaho Falls, Idaho) |
| ABSTRACT | In certain aspects of the disclosure, a method includes creating ink specimens. The method includes solidifying, via solvent evaporation, the ink specimens to identify Ni powders and Ti powders. The method includes debinding and pre-sintering the Ni powders and the Ti powders to form a porous NiTi skeleton. The method includes infiltrating the porous NiTi skeleton with a transient liquid. The method includes reaction sintering the NiTi of the porous NiTi skeleton and the Sn to reactively form TiNiSn. Ternary-phase thermoelectric materials formed by the method are also provided. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589066 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/20 (20130101) B22F 3/1021 (20130101) B22F 3/1039 (20130101) B22F 10/10 (20210101) B22F 2301/15 (20130101) B22F 2301/30 (20130101) B22F 2301/205 (20130101) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) Original (OR) Class H10N 10/854 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240285340 | Prakash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); Precision Microwave, Inc. (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Punit Prakash (Manhattan, Kansas); Hojjatollah Fallahi (Manhattan, Kansas); Austin Pfannenstiel (Manhattan, Kansas) |
| ABSTRACT | A method of ablating tissue uses a microwave ablation system with a plurality of applicators. The method includes the steps of having the applicators inserted into the tissue and located in and/or adjacent a target tissue section and having the system perform an ablation cycle by activating at least one of the applicators so that the at least one applicator emits electromagnetic radiation that is sufficiently strong to cause ablation of the target tissue section. The at least one applicator comprises a directional applicator that emits radiation to define an angular radiation pattern. The step of having the applicators inserted into the tissue includes the step of orienting the directional applicator so that the angular radiation pattern extends from the directional applicator toward the target tissue section. The method also includes the step of having the system perform a sensing cycle that includes the step of using one or more of the applicators to take a measurement associated with a dielectric property of the tissue. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 18/572857 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2018/00577 (20130101) A61B 2018/00654 (20130101) A61B 2018/00708 (20130101) A61B 2018/00779 (20130101) A61B 2018/00875 (20130101) A61B 2018/1823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285462 | Walsh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Conor J. Walsh (Cambridge, Massachusetts); Diogo Schwerz de Lucena (Cambridge, Massachusetts); Christina Glover (Cambridge, Massachusetts); Kristin Nuckols (Cambridge, Massachusetts); Maxwell Herman (Cambridge, Massachusetts); Diana Wagner (Cambridge, Massachusetts) |
| ABSTRACT | Rehabilitation systems and related methods are generally described. In some embodiments, a rehabilitation system may employ a flexible wearable robotic system which may be positioned on a user's appendage. The wearable robotic system may deform the appendage in a clinically relevant manner to facilitate rehabilitation of the appendage's motor function. In some embodiments, the wearable robotic system may include one or more sensors configured to measure the movement of the actuator based on its own actuation and/or the user's effort. The system may then convey such measurements to a processor for analysis and to a display to provide real-time feedback of the user's progress to the user and/or a clinician. In some embodiments, the actuator may be a glove. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573422 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0288 (20130101) Original (OR) Class A61H 2201/1638 (20130101) A61H 2201/5012 (20130101) A61H 2201/5043 (20130101) A61H 2230/605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285792 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Stephen Lippard (Cambridge, Massachusetts); Anna Czapar (Cleveland, Ohio); Yaorong Zheng (Cambridge, Massachusetts) |
| ABSTRACT | Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment. |
| FILED | Tuesday, January 30, 2024 |
| APPL NO | 18/426706 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5184 (20130101) A61K 31/555 (20130101) A61K 39/12 (20130101) A61K 47/6901 (20170801) Original (OR) Class A61K 2039/585 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2750/12022 (20130101) C12N 2750/12023 (20130101) C12N 2770/00034 (20130101) C12N 2770/00042 (20130101) C12N 2770/32022 (20130101) C12N 2770/32023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286767 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Ran Dai (West Lafayette, Indiana); Yuto Tanaka (West Lafayette, Indiana); Aditya Arjun Anibha (West Lafayette, Indiana) |
| ABSTRACT | A material collection system includes a planar structure, at least one actuator, and a plurality of pull cables. The planar structure includes a plurality of interconnected geometric panels having a plurality of holes therethrough, and each interconnection between two geometric panels defines a foldable coupling. The plurality of pull cables pass through the holes such that a first end of each pull cable is coupled with at least one geometric panel and a second end of each pull cable is coupled with the at least one actuator. The planar structure is operable between a first stable geometric state and a second stable geometric state. An actuation to pull each of the plurality of pull cables transitions the planar structure between the first stable geometric state and the second stable geometric state. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588418 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/1081 (20230801) Original (OR) Class B64G 1/2224 (20230801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240286918 | BARSOUM et al. |
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| FUNDED BY |
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| APPLICANT(S) | DREXEL UNIVERSITY (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel W. BARSOUM (Moorestown, New Jersey); Hussein Osama BADR (Philadelphia, Pennsylvania); Tarek Aly ELMELIGY (Philadelphia, Pennsylvania) |
| ABSTRACT | Processes of producing nanoparticles from solid phase precursor non-nanoparticles. Contacting a solid phase precursor non-nanoparticle selected from oxides of metals and metalloids, carbides of metals and metalloids, nitrides of metals and metalloids, borides of metals and metalloids, silicides of metals and metalloids, and phosphides of metals and metalloids, and mixtures thereof, with one or more onium ions in water in a vessel. Some processes can be one pot processes. The vessel is agitated and held at temperature for a time sufficient to form nanoparticles with the same crystalline structure as the solid phase precursor non-nanoparticle as determined by XRD and/or TEM. Nanoparticles made by the processes. Processes of use of the nanoparticles. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/572309 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 23/00 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/01 (20130101) C01P 2002/72 (20130101) C01P 2004/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287329 | MARKVICKA et al. |
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| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia); VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERITY (Blacksburg, Virginia); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Niger) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric MARKVICKA (Lincoln, Nebraska); Aaron HAAKE (Denton, Nebraska); Michael D. BARTLETT (Blacksburg, Virginia); Ravi Tej Anand TUTIKA (Christiansburg, Virginia); Gwyneth SCHLOER (Blacksburg, Virginia) |
| ABSTRACT | In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods of additive manufacture of emulsion compositions. In various aspects, the present disclosure relates to composite materials incorporating microstructures formed by inclusion compositions, and methods of their manufacture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, June 23, 2022 |
| APPL NO | 18/573837 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2021/003 (20130101) B29K 2075/00 (20130101) B29K 2083/00 (20130101) B29K 2105/16 (20130101) B29K 2505/00 (20130101) B29K 2869/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/023 (20130101) Original (OR) Class C09D 11/102 (20130101) C09D 11/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287533 | WONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Beth Israel Deaconess Medical Center (Boston, Massachusetts) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Beth Israel Deaconess Medical Center (Boston, Massachusetts) |
| INVENTOR(S) | Gerard C. L. WONG (Los Angeles, California); Jaime DE ANDA (Los Angeles, California); Wujing XIAN (Los Angeles, California); Xinhua CHEN (Boston, Massachusetts); Ciaran KELLY (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides methods for modifying gluten polypeptides to produce gluten polypeptides with a reduced inflammatory potential, as well as modified plants and compositions comprising modified gluten polypeptides with a reduced inflammatory potential. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/570935 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287603 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston system (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Shoujun Xu (Houston, Texas); Qiongzheng Hu (Houston, Texas); Yuhong Wang (Houston, Texas) |
| ABSTRACT | Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653029 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 7/52 (20130101) B01L 2200/0663 (20130101) B01L 2300/18 (20130101) B01L 2300/044 (20130101) B01L 2300/0654 (20130101) B01L 2300/0672 (20130101) B01L 2400/0439 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6818 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287786 | Nouh et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Nouh (Clarence Center, New York); Mohammad Ali Attarzadeh (Amherst, New York); Jesse Callanan (Buffalo, New York) |
| ABSTRACT | Embodiments of the present disclosure include metabeams with nonreciprocal dispersion. A host beam has a length along along a longitudinal axis and is configured to vibrate (oscillate) over its length. The vibration may be in a first direction perpendicular to the length of the host beam. A plurality of first resonators may be arranged in an array along the length of the host beam and extending from the host beam in a second direction which forms an angle (>0°) with respect to the first direction and an angle (>0°) with respect to the longitudinal axis of the host beam. Each first resonator has an arm having a first end attached to the host beam and an arm axis. The arm has a stiffness in the first direction which is selectively variable. A mass may be attached to the arm at a location which is spaced from the first end by a first distance. The stiffness of each first resonator arm is configured to be varied to impart nonreciprocal dispersion in the host beam. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507798 |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288518 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Ji Chen (Sugar Land, Texas); Jianfeng Zheng (Sugar Land, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to electric field generators that include a signal generator electrically connected to a power amplifier, a impedance matching circuit electrically connected to the power amplifier, and a power divider electrically connected to the impedance matching circuit and to at least one of a first wall, a second wall, a third wall, a fourth wall, or a base area. In an additional embodiment, the present disclosure pertains to method of determining radio frequency (RF)-induced heating on a medical device utilizing an electric field generator of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making electric field generators for testing a medical device. |
| FILED | Monday, May 06, 2024 |
| APPL NO | 18/656546 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/288 (20130101) Original (OR) Class Amplifiers H03F 1/565 (20130101) H03F 3/20 (20130101) H03F 2200/387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288701 | Ozcan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Yi Luo (Los Angeles, California); Ege Cetintas (Los Angeles, California); Yair Rivenson (Los Angeles, California) |
| ABSTRACT | A computer-free system and method is disclosed that uses an all-optical image reconstruction method to see through random diffusers at the speed of light. Using deep learning, a set of transmissive layers are trained to all-optically reconstruct images of arbitrary objects that are distorted by random phase diffusers. After the training stage, the resulting diffractive layers are fabricated and form a diffractive optical network that is physically positioned between the unknown object and the image plane to all-optically reconstruct the object pattern through an unknown, new phase diffuser. Unlike digital methods, all-optical diffractive reconstructions do not require power except for the illumination light. This diffractive solution to see through diffusive and/or scattering media can be extended to other wavelengths, and can fuel various applications in biomedical imaging, astronomy, atmospheric sciences, oceanography, security, robotics, autonomous vehicles, among many others. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/571653 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1866 (20130101) G02B 6/4206 (20130101) G02B 27/0944 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289485 | Moataz |
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| FUNDED BY |
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| APPLICANT(S) | MongoDB, Inc. (New York, New York) |
| ASSIGNEE(S) | MongoDB, Inc. (New York, New York) |
| INVENTOR(S) | Tarik Moataz (Brooklyn, New York) |
| ABSTRACT | Methods and system implement solutions for integrating encryption and emulation into native database formats and/or architectures. “Native” database is used to describe a database that has not been designed for end to end encryption, an off the shelf database deployment, and/or a commercially available database. According to some embodiments, various encryption systems and methods employ emulation operations to enable a native database and native database functions to leverage full encryption primitives. Various aspects integrate emulation operations into standard database implementations, where the emulation enables native database functions to operate on entirely encrypted data. |
| FILED | Friday, April 26, 2024 |
| APPL NO | 18/648135 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/213 (20190101) G06F 21/6227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289524 | BARKER |
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| FUNDED BY |
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| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating a superconducting electronic circuit design. The system includes a memory and a processor. The processor simulates a superconducting electronic circuit design using a first process variation to produce a first score and simulates the superconducting electronic circuit design using a second process variation to produce a second score. The processor, in response to determining that the first score is lower than the second score, simulates the superconducting electronic circuit design using the first process variation and a first design variation to produce a third score and simulates the superconducting electronic circuit design using the first process variation and a second design variation to produce a fourth score. The processor updates the superconducting electronic circuit design using the first process variation and the first design variation in response to determining that the third score is higher than the fourth score. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113582 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2119/02 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289626 | MAJEWICZ FEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Ann MAJEWICZ FEY (Austin, Texas); Yi ZHENG (Austin, Texas) |
| ABSTRACT | Devices, systems and methods to detect stress using kinematic data are disclosed herein. In certain embodiments a spatial attention mechanism is used to describe the contribution of each kinematic feature to the classification of normal/stressed movements. Some embodiments comprise determining if the kinematic data from a user belong to a class of sub-movements associated with known signatures found to highly correlate with when the user is experiencing motor degradation due to high psychological stress versus a normal class of movements where the user is unaffected by stress. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436313 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Original (OR) Class G06N 3/0442 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289638 | Avestimehr et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir Salman Avestimehr (Rancho Palos Verdes, California); Qian Yu (Lawrence Township, Indiana); Chaoyang He (Irvine, California); Jinhyun So (Los Angeles, California); Chien-Sheng Yang (Alhambra, California) |
| ABSTRACT | Systems and methods to generate a model based on a subset of models generated at remote devices include a first device operatively coupled with a second device. The first device can generate, based on a model parameter and data restricted to the first device, a first model via machine learning, partition the first model into a plurality of local mask shares each including a distinct portion of the first model, encode one or more of the plurality of local mask shares into a corresponding first plurality of encoded shares, and generate an aggregation of encoded shares including a first encoded share having a first index among the first plurality of encoded shares and a second encoded share having the first index among a second plurality of encoded shares. The second encoded share includes a distinct portion of a second model generated by a second device via machine learning. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 18/682656 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/098 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289665 | Pichler et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannes Pichler (Pasadena, California); Harry Jay Levine (Cambridge, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Ahmed Omran (Cambridge, Massachusetts); Alexander Keesling Contreras (Cambridge, Massachusetts); Giulia Semeghini (Cambridge, Massachusetts); Vladan Vuletic (Cambridge, Massachusetts); Markus Greiner (Cambridge, Massachusetts); Tout Wang (Cambridge, Massachusetts); Sepehr Ebadi (Cambridge, Massachusetts) |
| ABSTRACT | A device includes a grouping of N qubits, where N is equal to two or more, and a coherent light source configured to, given selected values for a set of parameters of at least a first and a second laser pulse, the parameters selected from a relative phase shift, a laser frequency, a laser intensity, and a pulse duration: apply at least the first and second laser pulses to all qubits within the grouping of N qubits, thereby coupling a non-interacting quantum state |1 |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573270 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289826 | CRANSHAW et al. |
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| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Justin CRANSHAW (Pittsburgh, Pennsylvania); Raz SCHWARTZ (Pittsburgh, Pennsylvania); Jason I. HONG (Pittsburgh, Pennsylvania); Norman SADEH-KONIECPOL (Pittsburgh, Pennsylvania) |
| ABSTRACT | Computer-based systems and methods for discovering neighborhood clusters in a geographic region, where the clusters have a mix of venues and are determined based on venue check-in data. The mix of venues for the clusters may be based on the social similarity between pairs of venues; or emblematic of certain neighborhood typologies; or emblematic of temporal check-in pattern types; or combinations thereof. The neighborhood clusters that are so discovered through venue-check in data could be used for many commercial and civic purposes. |
| FILED | Monday, March 18, 2024 |
| APPL NO | 18/607995 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289973 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Temep, Arizona) |
| INVENTOR(S) | Xiao Liu (Tempe, Arizona); Geoffrey Clark (Phoenix, Arizona); Heni Ben Amor (Tempe, Arizona) |
| ABSTRACT | An environment-aware prediction and control framework, which incorporates learned environment and terrain features into a predictive model for human-robot symbiotic walking, is disclosed herein. First, a compact deep neural network is introduced for accurate and efficient prediction of pixel-level depth maps from RGB inputs. In turn, this methodology reduces the size, weight, and cost of the necessary hardware, while adding key features such as close-range sensing, filtering, and temporal consistency. In combination with human kinematics data and demonstrated walking gaits, the extracted visual features of the environment are used to learn a probabilistic model coupling perceptions to optimal actions. The resulting data-driven controllers. Bayesian Interaction Primitives, can be used to infer in real-time optimal control actions for a lower-limb prosthesis. The inferred actions naturally take the current state of the environment and the user into account during walking. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 18/570521 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/6607 (20130101) A61F 2002/704 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/55 (20170101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/20016 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290473 | Ozcan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Jingxi Li (Los Angeles, California); Yair Rivenson (Los Angeles, California); Xiaoran Zhang (Los Angeles, California); Philip O. Scumpia (Los Angeles, California); Jason Garfinkel (Los Angeles, California); Gennady Rubinstein (Los Angeles, California) |
| ABSTRACT | A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/572113 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0071 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 15/08 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290957 | Zhu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Notheastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Zhu (Newton, Massachusetts) |
| ABSTRACT | A MoS2@polyacrylonitrile-derived porous carbon fiber core-shell structure for use in all-solid-state lithium-sulfur batteries (ASSLSBs) is disclosed. The core-shell structure comprises a core comprising polyacrylonitrile-derived porous carbon fibers (PPCF) with surface layer pores; and a shell comprising a MoS2 nanosheet that is uniformly distributed on the surface of the core. Methods for making the core-shell structure are also disclosed, as well as methods of using the core-shell structure for ASSLSBs. The use of a MoS2@PPCF core-shell structure in an ASSLSB resulted in improved electrochemical performance with ultrahigh specific capacity, high cycling stability, and high-capacity retention. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585713 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/5815 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/021 (20130101) H01M 2004/028 (20130101) H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290976 | Miljanic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Ognjen Miljanic (Houston, Texas); Yan Yao (Pearland, Texas); Said Jalife Jacobo (Houston, Texas); Judy Wu (Manvel, Texas); Alexandra Robles (San Francisco, California) |
| ABSTRACT | This invention relates to materials for electrodes, to materials for lithium-ion batteries, and to materials for lithium-ion storage. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/216410 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 49/792 (20130101) C07C 2603/92 (20170501) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/60 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291010 | Mahmoodi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of The Stevens Institute of Technology (Hoboken, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Reza Mahmoodi (Berkeley, California); Ronald Besser (New Providence, New Jersey); Matt Mayer (Binghamton, New York); Pei-Kang Sun (Hoboken, New Jersey) |
| ABSTRACT | Methods useful for the manufacturing of microfluidic cells useful in electronics and other applications are disclosed. In this technique, an air cushioned pressure supplies the force to bond a membrane, which can be made from one or more of the sulfonated tetrafluoroethylene polymers commercially known as Nafion™ (i.e., proton exchange membranes) or from other thermoplastic substrates. A substrate is compressed and templated while it is simultaneously sealed inside the cell. The resultant microcells are strongly sealed while being patterned according to their application. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 18/559960 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1004 (20130101) Original (OR) Class H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291237 | Krishnamoorthy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Axalume, Inc. (, None) |
| ASSIGNEE(S) | Axalume, Inc. (San Diego, California) |
| INVENTOR(S) | Ashok V. Krishnamoorthy (San Diego, California); Alexey Kovsh (San Diego, California) |
| ABSTRACT | An optical source is described. This optical source may include: an optical cavity that includes at least one mirror; and a semiconductor laser chip having multiple epitaxial gain layers, where the epitaxial gain layers act as a gain medium that provides multiple lasing wavelengths in a band of frequencies without mode hopping and/or with significantly reduced mode beating below a predetermined value. Moreover, the optical source may include an optical component that selects laser modes of the optical cavity, where the optical component includes: an aperiodic grating; an echelle grating having a common arm that includes the epitaxial gain layers and multiple output arms that provide the lasing wavelengths; or a set of ring resonators that provide the lasing wavelengths. |
| FILED | Tuesday, February 28, 2023 |
| APPL NO | 18/115339 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/026 (20130101) H01S 5/125 (20130101) H01S 5/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240291558 | Kassas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak Kassas (Columbus, Ohio); Mohammad NEINAVAIE (Irvine, California); Joe Khalife (Irvine, California) |
| ABSTRACT | Processes and device configurations are provided for extracting navigation observables and navigation using low earth orbit (LEO) signals. Methods and systems described herein can detect one or more low earth orbit (LEO) satellite downlink signals, and determine carrier phase observables and Doppler observables from the downlink signals in order to determine position estimates. Processes can include determining at least one carrier phase observable from the one or more LEO satellite downlink signals, wherein determining the at least at least one carrier phase observable includes tracking a modified beat carrier phase of a sample of a detected LEO signal by performing an estimation operation for a time period and adaptive updating of measurement noise. Processes can include use of position estimates for navigation and navigation based on carrier phase tracking. Processes are also provided for determination of satellite synchronization signals (SS) from downlink transmissions using subspace detection. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570319 |
| CURRENT CPC | Transmission H04B 7/195 (20130101) H04B 7/1855 (20130101) Original (OR) Class H04B 7/18589 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240286191 | Sherman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Powdermet, Inc. (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio) |
| ABSTRACT | A structured three-phase composite which include a metal phase, a ceramic phase, and a gas phase that are arranged to create a composite having low thermal conductivity, having controlled stiffness, and a CTE to reduce thermal stresses in the composite when exposed to cyclic thermal loads. The structured three-phase composite is useful for use in structures such as, but not limited to, heat shields, cryotanks, high speed engine ducts, exhaust-impinged structures, and high speed and reentry aeroshells. |
| FILED | Tuesday, January 16, 2024 |
| APPL NO | 18/413916 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/1112 (20130101) Original (OR) Class B22F 2003/1106 (20130101) B22F 2998/10 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 5/18 (20130101) B32B 5/20 (20130101) Alloys C22C 1/1084 (20130101) C22C 32/0031 (20130101) C22C 32/0036 (20130101) C22C 32/0078 (20130101) C22C 49/00 (20130101) C22C 49/06 (20130101) C22C 49/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287259 | KORNFIELD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (PASADENA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia A. KORNFIELD (PASADENA, California); Ming-Hsin WEI (PASADENA, California) |
| ABSTRACT | Described herein are associative polymers capable of controlling a physical and/or chemical property of non-polar compositions and related compositions, methods and systems. Associative polymers herein described have a non-polar backbone and functional groups presented at ends of the non-polar backbone, with a number of the functional groups presented at the ends of the non-polar backbone formed by associative functional groups capable of undergoing an associative interaction with another associative functional group with an association constant (k) such that the strength of each associative interaction is less than the strength of a covalent bond between atoms and in particular less than the strength of a covalent bond between backbone atoms. |
| FILED | Tuesday, January 30, 2024 |
| APPL NO | 18/427583 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 83/00 (20130101) C08G 83/005 (20130101) Original (OR) Class C08G 83/008 (20130101) C08G 2261/63 (20130101) C08G 2261/64 (20130101) C08G 2261/72 (20130101) C08G 2261/132 (20130101) C08G 2261/418 (20130101) C08G 2261/1644 (20130101) C08G 2261/3323 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/0008 (20130101) Compositions of Macromolecular Compounds C08L 101/02 (20130101) C08L 101/08 (20130101) C08L 101/025 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/195 (20130101) C10L 1/236 (20130101) C10L 1/1658 (20130101) C10L 10/02 (20130101) C10L 10/08 (20130101) C10L 2230/22 (20130101) C10L 2250/04 (20130101) Pipe-line Systems; Pipe-lines F17D 1/17 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288534 | ARUMUGAM |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darmindra D. ARUMUGAM (Pasadena, California) |
| ABSTRACT | Methods and receiving devices to detect radio frequency signals are disclosed. The described methods and devices make use of quantum Rydberg modes to detect direct signals, such as satellite signals, and indirect scattered signals, such as signals from constructions or individuals inside constructions. The incoming radio signals to the receiver are automatically down-converted for detection via electromagnetic induced transparency (EIT). The quantum Rydberg modes are obtained though optical excitation of alkali metal atoms. |
| FILED | Monday, February 05, 2024 |
| APPL NO | 18/432413 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/032 (20130101) Original (OR) Class G01S 13/003 (20130101) G01S 13/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240288886 | MISTRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| ASSIGNEE(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| INVENTOR(S) | Mital Chandrakant MISTRY (Richmond, Texas); Zachary W. LEUTWYLER (Richmond, Texas); Aaron P. RICHIE (Missouri City, Texas); Manmohan S. KALSI (Houston, Texas) |
| ABSTRACT | A passive thermal control valve comprising a thermal actuator coupled to a valve body having first and second ports. The thermal actuator including an actuator body having an inner bore. An adjustment stop engages the actuator body. A cylinder is received within the actuator body inner bore and the cylinder has a cylinder bore open at one end. An actuator spring within the actuator body biases the cylinder towards the adjustment stop. An actuator rod is at least partially received within the cylinder and has first and second ends. At least a portion of the actuator rod is allowed to extend through the open cylinder bore. A sealing element forms a seal between the actuator rod and the cylinder and defines a sealed chamber within the cylinder. A thermal fluid is contained within the cylinder. A lever mechanism is connected to the valve body and includes a lever having a first end connected to the valve body. A valve spool is connected to a lever second end. The valve spool is arranged and designed to close the first port and allow a system fluid to flow through the second port, close the second port and allow the system fluid to flow through the first port, or allow the system fluid to flow through both the first and second ports. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640268 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/002 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289968 | Christian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | John Allen Christian (Marietta, Georgia); Paul Dickson McKee (Averill Park, New York); Michael Kudenov (Raleigh, North Carolina); Hoang Nguyen (Raleigh, North Carolina) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | John Allen Christian (Marietta, Georgia); Paul Dickson McKee (Averill Park, New York); Michael Kudenov (Raleigh, North Carolina); Hoang Nguyen (Raleigh, North Carolina) |
| ABSTRACT | In an embodiment, there is provided a method for determining a spacecraft instantaneous velocity using starlight. The method includes determining, by a star pairing module, a plurality of star pairs in a selected star field image. The selected star field image includes a plurality of star images. The method includes estimating, by a line of sight estimation module, an apparent bearing direction to each star in at least some of the plurality of star pairs; determining, by the line of sight estimation module, a respective apparent inter-star angle for each star pair of the least some star pairs; and estimating, by a velocity estimation module, a spacecraft velocity to within a total velocity error based, at least in part, on the apparent inter-star angles. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573667 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/361 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/24 (20130101) G01C 21/025 (20130101) Image Data Processing or Generation, in General G06T 7/246 (20170101) Original (OR) Class G06T 2207/10032 (20130101) G06T 2207/30252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290509 | HOWE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy M. HOWE (SCOTTSDALE, Arizona); Steven D. HOWE (PHOENIX, Arizona) |
| ABSTRACT | A customizable thin plate fuel form and reactor core therefor are disclosed. The thin plate fuel will comprise a fuel material embedded within a matrix material, with the entire unit having a coating. The thin plate fuel may be flat or curved and will have flow channels formed within at least the top surface of the fuel plate. The structure of the thin plate fuel will make it easier for coating with Tungsten or any other suitable material that will help contain any byproducts, prevent reactions with the working fluid, and potentially provide structural support to the thin plate fuel. |
| FILED | Monday, January 22, 2024 |
| APPL NO | 18/419046 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/20 (20130101) G21C 3/36 (20130101) Original (OR) Class G21C 3/64 (20130101) G21C 3/626 (20130101) G21C 5/16 (20130101) G21C 5/18 (20130101) G21C 5/126 (20130101) G21C 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240285964 | Keller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Corey Keller (Redwood City, California); Jessica Ross (Stanford, California) |
| ABSTRACT | Systems and methods for sensory entrained TMS in accordance with embodiments of the invention are illustrated. One embodiment includes a method for transcranial magnetic stimulation, including identifying a beat offset in a music track that when played for a patient is associated with desynchronization of alpha waves and synchronization of beta waves of the patient, playing back the music track for the patient, and providing transcranial magnetic stimulation pulses using a transcranial magnetic stimulation device to the patient, where the pulses are delivered a time equal to the beat offset with respect to beats in the music track. |
| FILED | Monday, February 26, 2024 |
| APPL NO | 18/587541 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287153 | Jackson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M. Jackson (Miami, Florida); Andrew V. Schally (Miami Beach, Florida); Renzhi Cai (Fulshear, Texas) |
| ABSTRACT | Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/25 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 35/00 (20180101) Peptides C07K 14/60 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287175 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); John Vincent Pluvinage (Atherton, California); Michael C. Bassik (Stanford, California); Michael Haney (Stanford, California); Benjamin Smith (Stanford, California); Carolyn Bertozzi (Stanford, California) |
| ABSTRACT | Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells. |
| FILED | Friday, December 01, 2023 |
| APPL NO | 18/526952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 39/001113 (20180801) A61K 39/3955 (20130101) A61K 47/6815 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0097 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/77 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Enzymes C12Y 302/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240289787 | Parthasarathy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arpitha Parthasarathy (Washington, District of Columbia); Irma Molina (Washington, District of Columbia) |
| ABSTRACT | Methods, systems, and apparatuses are described that are configured for an improved R&D process flow that involves peer-to-peer collaborations, linguistics services, peer review of manuscripts and the outcome of which will be stored as digitized medical/clinical library for developing public relations and marketing material for patient education and engagement using blockchain technology. A plurality of digital assets may be stored in a blockchain network. Each digital asset may be associated with a transaction. Each transaction may be associated with one or more peer nodes of a plurality of peer nodes in the blockchain network. The one or more digital assets may be sent based on one or more transactions satisfying a peer node threshold. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583346 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/223 (20130101) G06Q 20/389 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240290473 | Ozcan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Jingxi Li (Los Angeles, California); Yair Rivenson (Los Angeles, California); Xiaoran Zhang (Los Angeles, California); Philip O. Scumpia (Los Angeles, California); Jason Garfinkel (Los Angeles, California); Gennady Rubinstein (Los Angeles, California) |
| ABSTRACT | A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/572113 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0068 (20130101) A61B 5/0071 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 15/08 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240284884 | Prather et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall S. Prather (Rocheport, Missouri); Kevin D. Wells (Columbia, Missouri); Kristin M. Whitworth (Columbia, Missouri) |
| ABSTRACT | The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640282 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/15 (20130101) A01K 2217/075 (20130101) A01K 2227/108 (20130101) A01K 2267/02 (20130101) Peptides C07K 14/7056 (20130101) C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240285594 | Messenger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristen M. Messenger (Raleigh, North Carolina); Emily Wiloch (Raleigh, North Carolina); Lilly Smith (Raleigh, North Carolina); Ronald E. Baynes (Raleigh, North Carolina); Emma Nixon (Raleigh, North Carolina); Hiroko Enomoto (Raleigh, North Carolina); Monique Pairis-Garcia (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods related to the treatment and/or reduction of pain in an animal. In particular, the present disclosure provides novel compositions and methods for treating and/or reducing pain in an animal (e.g., a pig) by administering an analgesic intranasally. The composition and methods described herein provide a more convenient and effective means for treating and/or reducing pain in an animal (e.g., pain associated with industrial processing) in a manner that also improves the animal's health and welfare. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589673 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/44 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240287309 | Yucel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umut Yucel (Manhattan, Kansas); Valentina Trinetta (Manhattan, Kansas); Scott Bean (Manhattan, Kansas) |
| ABSTRACT | One or more embodiments of the invention are directed toward biodegradable films from distiller's dried grains with solubles (DDGS), especially sorghum DDGS, and methods of making the same. The films, which are suitable for use as packaging films, can be produced by directly conditioning the DDGS via a milling process, such as wet milling (e.g., colloid mill and ball milling) in water or a sodium hydroxide solution. The milled slurry is co-dissolved with plasticizers and stabilizers (preferably all less than 1% by weight) in a mixture of water and an organic solvent. The mixture is then used for film processing via pour-casting. The biodegradable films have significant antioxidant and antimicrobial activities related to their phenolic content. |
| FILED | Wednesday, June 29, 2022 |
| APPL NO | 18/570559 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 65/466 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2399/00 (20130101) C08J 2405/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/053 (20130101) Compositions of Macromolecular Compounds C08L 99/00 (20130101) Original (OR) Class C08L 2201/06 (20130101) C08L 2203/16 (20130101) C08L 2205/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240291813 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (, None) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark A. Fry (Marco Island, Florida) |
| ABSTRACT | In an example, a meeting system for communication between a client and a host includes a meeting server; a first computer; a secure meeting kiosk including a kiosk interior for a person to enter to attend a first meeting session, the secure meeting kiosk including an access portal for entry into and exit from the kiosk interior; a second computer disposed inside the secure meeting kiosk; a digital lock connected to the access portal to lock the access portal in a locked state and unlock the access portal in an unlocked state; and an external biometric capture device configured to obtain outside biometric information of the person when the person is outside of the kiosk interior. The digital lock switches between the unlocked state and the locked state based at least in part on the outside biometric information obtained by the external biometric capture device. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/384619 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/102 (20130101) H04L 63/0861 (20130101) Original (OR) Class H04L 65/1073 (20130101) H04L 65/1093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20240291558 | Kassas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak Kassas (Columbus, Ohio); Mohammad NEINAVAIE (Irvine, California); Joe Khalife (Irvine, California) |
| ABSTRACT | Processes and device configurations are provided for extracting navigation observables and navigation using low earth orbit (LEO) signals. Methods and systems described herein can detect one or more low earth orbit (LEO) satellite downlink signals, and determine carrier phase observables and Doppler observables from the downlink signals in order to determine position estimates. Processes can include determining at least one carrier phase observable from the one or more LEO satellite downlink signals, wherein determining the at least at least one carrier phase observable includes tracking a modified beat carrier phase of a sample of a detected LEO signal by performing an estimation operation for a time period and adaptive updating of measurement noise. Processes can include use of position estimates for navigation and navigation based on carrier phase tracking. Processes are also provided for determination of satellite synchronization signals (SS) from downlink transmissions using subspace detection. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 18/570319 |
| CURRENT CPC | Transmission H04B 7/195 (20130101) H04B 7/1855 (20130101) Original (OR) Class H04B 7/18589 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240284863 | Nuzhdin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sergey Nuzhdin (Los Angeles, California); Melisa Osborne (Los Angeles, California); Gary Molano (Los Angeles, California); Bernadeth Tolentino (Los Angeles, California) |
| ABSTRACT | This disclosure describes the microbial network and community assembly patterns of brown macro algae, e.g., Macrocystis pyrifera gametophyte germplasm, cultures used to cultivate an offshore farm and identify network features associated with increased biomass of mature sporophytes. Several network features, such as clustering coefficient and edge ratios, significantly vary with biomass outcomes; also, gametophytes that become low- or high biomass sporophytes have different hub taxa. This disclosure describes microbial community dynamics in M. pyrifera germplasm cultures and development of early life stage inoculants used on seaweed cultivars to increase biomass yield. |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/589339 |
| CURRENT CPC | Harvesting; Mowing A01D 44/00 (20130101) Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 33/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 13/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20240289524 | BARKER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synopsys, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron John BARKER (Broomfield, Colorado) |
| ABSTRACT | The present disclosure describes systems and methods for generating a superconducting electronic circuit design. The system includes a memory and a processor. The processor simulates a superconducting electronic circuit design using a first process variation to produce a first score and simulates the superconducting electronic circuit design using a second process variation to produce a second score. The processor, in response to determining that the first score is lower than the second score, simulates the superconducting electronic circuit design using the first process variation and a first design variation to produce a third score and simulates the superconducting electronic circuit design using the first process variation and a second design variation to produce a fourth score. The processor updates the superconducting electronic circuit design using the first process variation and the first design variation in response to determining that the third score is higher than the fourth score. |
| FILED | Thursday, February 23, 2023 |
| APPL NO | 18/113582 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/3308 (20200101) Original (OR) Class G06F 2119/02 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240289725 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Albert Tartal (Baltimore, Maryland); Gabriel Michael Yessin (Arlington, Virginia); Dominique Danielle Strothers (Front Royal, Virginia); Joram Shenhar (Fairfax, Virginia); Joel Locknauth Dewnandan (Bladensburg, Maryland); Terry Martin Gingell (Spotsylvania, Virginia); James Edmund Matthews (Bowie, Maryland) |
| ABSTRACT | A process for verifying an item deposit via a smart drop box. The process includes an item receptacle, a processor in communication with the item receptacle, a scanning device, and a database. The item receptacle is configured to receive an item from a user, scan the item, and generate item information. The processor is configured to compare the item information generated with identified item information from the database. If the information generated matches the information from the database, the item is accepted. In some embodiments, the deposit verification includes a printed receipt and/or an electronic verification. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654905 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0832 (20130101) Original (OR) Class G06Q 10/0833 (20130101) G06Q 20/202 (20130101) G06Q 20/203 (20130101) G06Q 20/204 (20130101) G06Q 20/209 (20130101) G06Q 50/60 (20240101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00896 (20130101) Handling of Coins or Valuable Papers, e.g Testing, Sorting by Denominations, Counting, Dispensing, Changing or Depositing G07D 11/009 (20130101) G07D 11/14 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 29, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240829.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page