FedInvent™ Patent Applications
Application Details for Thursday, September 05, 2024
This page was updated on Thursday, September 05, 2024 at 05:27 PM GMT
Department of Health and Human Services (HHS)
| US 20240292830 | Daniele et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Stefano Daniele (New Haven, Connecticut); Nenad Sestan (New Haven, Connecticut); John Silbereis (New Haven, Connecticut); Zvonimir Vrselja (New Haven, Connecticut) |
| ABSTRACT | The invention provides a system for normothermic, ex vivo restoration and preservation of an intact mammalian brain, and other organs. In certain aspects, the system is capable of preserving a brain as well as other organs, maintaining cellular integrity and cellular function for hours post mortem or after global ischemia. The invention also provides synthetic brain perfusate formulations, including a novel brain perfusion medium (BPM), which are able to reduce reperfusion injury, stimulate recovery from hypoxia, prevent edema and metabolically support the energy needs of brain function. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/648749 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293072 | Machizawa |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
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| INVENTOR(S) | Masahiro Machizawa (Providence, Rhode Island) |
| ABSTRACT | Neurofeedback training can include a subject visualizing a mental image, neural signals that quantify visual working memory related to the mental image can be recorded using scalp electrodes. The subject's performance with the visualization can be scored based on neural activity related to a cognitive function within the neural signals during an induction period. Feedback can be provided to the subject based on the scoring to inform the subject of a success rate related to the visual working memory. The goal of the neurofeedback training can be to improve the subject's cognitive function. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 18/578379 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/375 (20210101) Original (OR) Class A61B 5/378 (20210101) A61B 5/384 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293077 | Kumar et al. |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Vivek Kumar (Bar Harbor, Maine); Allan I. Pack (Bar Harbor, Maine); Brian Geuther (Bar Harbor, Maine); Joshy George (Bar Harbor, Maine); Mandy Chen (Bar Harbor, Maine) |
| ABSTRACT | Systems and methods described herein provide techniques for determining sleep state data by processing video data of a subject. Systems and methods may determine a plurality of features from the video data, and may determine sleep state data for the subject using the plurality of features. In some embodiments, the sleep state data may be based on frequency domain features and/or time domain features corresponding to the plurality of features. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/572717 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/4812 (20130101) Original (OR) Class A61B 5/4839 (20130101) A61B 5/7267 (20130101) A61B 2503/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293090 | UNBERATH et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Mathias UNBERATH (Baltimore, Maryland); Jan-Nico ZAECH (Zurich, Switzerland) |
| ABSTRACT | A device may receive an X-ray image captured by a C-arm CBCT device at a particular position defined by a six-degree of freedom pose relative to an anatomy, and may process the X-ray image, with a machine learning model, to determine a predicted quality of next possible X-ray images provided by the C-arm CBCT device. The device may utilize the machine learning model, to identify a particular X-ray image, of the next possible X-ray images, with a greatest predicted quality and to update the six-degree of freedom pose based on the particular X-ray image. The device may provide, to the C-arm CBCT device, data that identifies the updated six-degree of freedom pose to cause the C-arm CBCT device to adjust to a new position based on the updated six-degree of freedom pose. |
| FILED | Thursday, May 09, 2024 |
| APPL NO | 18/659587 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/12 (20130101) A61B 6/032 (20130101) Original (OR) Class A61B 6/505 (20130101) A61B 6/563 (20130101) A61B 6/4085 (20130101) A61B 6/4441 (20130101) A61B 6/5258 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293215 | MEHTA et al. |
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| APPLICANT(S) | The Board of Trustees of The Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of The Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Shreya MEHTA (San Francisco, California); Nicholas R. DAMIANO (San Francisco, California); Tiffany E. CHAO (Palo Alto, California); John P. WOOCK (Irvine, California) |
| ABSTRACT | Indwelling body lumen expanders which allow for the maintenance and patency of a body lumen, such as the prostatic urethra to relieve urethral obstruction, are described. Because the one or more expanders are configured to be relatively larger in diameter than the diameter of the body lumen, the expanders may become invaginated into the lumen wall thus enabling the prostheses to avoid fluid exposure which in turn prevent the prostheses from becoming encrusted or calcified. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177619 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) Original (OR) Class A61F 2/95 (20130101) A61F 2002/047 (20130101) A61F 2230/0065 (20130101) A61F 2250/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293259 | Keller |
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| APPLICANT(S) | Centricity Vision, Inc. (Carlsbad, California) |
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| INVENTOR(S) | Christopher Guild Keller (El Cerrito, California) |
| ABSTRACT | A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye. A sliding element is disposed within the handpiece and a suction cup is mounted to the sliding element. The sliding element can be translated to move the suction cup into and out of the handpiece. A compression mechanism associated with the suction cup and the handpiece compresses the suction cup for deployment through the tip of the handpiece. The suction cup can expand inside the anterior chamber into a cutting position on the lens capsule. A cutting element mounted to the suction cup is used to cut a portion of the lens capsule and to remove the portion from the eye. The cutting element may be mounted to a cutting element support structure in a way that prevents heating of the device. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653892 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/14 (20130101) A61B 18/1402 (20130101) A61B 2018/00291 (20130101) A61B 2018/00321 (20130101) A61B 2018/00601 (20130101) A61B 2018/1407 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) A61F 9/00754 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293289 | Melo et al. |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Mary Anne S. Melo (Hanover, Maryland); Michael D. Weir (Silver Spring, Maryland); Lamia Sami Mokeem (Jessup, Maryland) |
| ABSTRACT | Provided herein are dental adhesives that contain a dental adhesive material and a multifunctional magnetic platform. The multifunctional magnetic platform has a core-shell structure. The core includes magnetic microparticles and an antibiotic with the core capped by an antibacterial silane coating. Also provided are methods utilizing the dental adhesives for increasing longevity of a dental restoration and for restoring a tooth in a subject. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/593423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/30 (20200101) A61K 6/69 (20200101) Original (OR) Class A61K 6/71 (20200101) A61K 6/76 (20200101) A61K 31/155 (20130101) A61K 31/695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293308 | Karp et al. |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Jeffrey M Karp (Brookline, Massachusetts); Kisuk Yang (Cambridge, Massachusetts); Allison E Hamilos (Brookline, Massachusetts); Eoin O'Cearbhaill (Boston, Massachusetts); Peter Anthony Jones (Medford, Massachusetts) |
| ABSTRACT | A cell encapsulating implantable device, including: a cell chamber accommodating a plurality of biological cells disposed within a fluid, the cell chamber at least partially enclosed within an immuno-isolative membrane which permits diffusive exchange of nutrients between the fluid and a tissue in which the device is implanted for sustaining the plurality of biological cells, and the cell chamber being configured to accommodate flow of fluid therethrough. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/915606 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Original (OR) Class A61K 35/39 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293316 | GIANNESCHI et al. |
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| APPLICANT(S) | Ramot at Tel-Aviv University Ltd. (Tel-Aviv, Israel); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Ramot at Tel-Aviv University Ltd. (Tel-Aviv, Israel); Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Nathan GIANNESCHI (Evanston, Illinois); Yifei LIANG (Evanston, Illinois); Claudia Battistella (Evanston, Illinois); Lihi ADLER-ABRAMOVICH (Tel-Aviv, Israel); Eyal ROSEN (Tel-Aviv, Israel); Carlos NEMCOVSKY (Tel-Aviv, Israel); Nathan SCHIFFMANN (Tel-Aviv, Israel); Michal HALPERIN-STERNFELD (Tel-Aviv, Israel) |
| ABSTRACT | Micellar particles formed of a plurality of block copolymers, compositions comprising same, copolymers used to form the particles, and polymeric aggregates formed therefrom are provided. The micellar particles are for use in the treatment of inflammation, including chronic inflammation. The block copolymers forming the particles include at least a first block and a second block. The first block has an anti-inflammatory agent covalently attached, directly or via a linking moiety or group, to at least a portion of its backbone units; and the second block has a hydrophilic moiety that comprises an amino acid sequence that is capable of interacting with an inflammatory biomarker covalently attached to at least a portion of its backbone units, and the particle features a core made of the first block and a hydrophilic shell made of the second block. |
| FILED | Thursday, January 18, 2024 |
| APPL NO | 18/415811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 47/59 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293334 | Campochiaro et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimmore, Maryland) |
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| INVENTOR(S) | Peter A. Campochiaro (Baltimore, Maryland); Jordan Green (Nottingham, Maryland); Jayoung Kim (Baltimore, Maryland); Jikui Shen (Dundalk, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye. |
| FILED | Monday, December 11, 2023 |
| APPL NO | 18/535180 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) A61K 9/5031 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293349 | Sanders et al. |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
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| INVENTOR(S) | Martin E. Sanders (Spring, Texas); Powel H. Brown (Houston, Texas); Cassandra Moyer (Houston, Texas); Abhijit Mazumdar (Houston, Texas) |
| ABSTRACT | The present specification provides combinations of active agents for the improved treatment of Her2+ cancers and associated methods of treatments. The combinations comprise an RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/649476 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/216 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293361 | Cunningham et al. |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
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| INVENTOR(S) | Lisa Lynn Cunningham (Rockville, Maryland); Nicole C. Schmitt (Potomac, Maryland); Katherine Ann Fernandez (Montgomery Village, Maryland) |
| ABSTRACT | The invention relates to methods and compositions for treating or preventing drug-induced hearing loss. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/791239 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) Original (OR) Class A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293365 | WANG et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Yingxiao WANG (San Diego, California); Longwei LIU (San Diego, California); Shaoying LU (San Diego, California) |
| ABSTRACT | In alternative embodiments, provided are methods for treating or ameliorating hyperactive ZAP70 kinase-related diseases or conditions, including any disease or conditions mediated by hyperactive T cells or disease or condition whose pathology is initiated, aggravated or mediated by hyperactive T cells, such as autoimmune disease (including for example, an autoimmune disease requiring allogeneic hematopoietic cell transplantation (HCT) in patients, rheumatoid arthritis (RA), inflammatory bowel disease (IBD), Crohn's disease, type 1 diabetes, multiple sclerosis, uncontrollable bullous pemphigoid, colitis, celiac disease, dermatitis and proteinuria), organ transplant rejection, graft-versus-host disease (GVHD) and/or B cell chronic lymphocytic leukemia (CLL). In alternative embodiments, methods as provided herein comprise administering to an individual in need thereof the FDA-approved cancer drug sunitinib (or SUTENT™), or salts or formulations thereof, for example sunitinib malate. |
| FILED | Tuesday, June 28, 2022 |
| APPL NO | 18/575100 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293377 | RISHI et al. |
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| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); Wayne State University (Detroit, Michigan) |
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| INVENTOR(S) | ARUN K. RISHI (Troy, Michigan); NAVNATH GAVANDE (Detroit, Michigan) |
| ABSTRACT | Described herein are compositions and methods for treating cancer in a subject. The compositions include selective NF-κB inhibitor inhibitors. The methods include inhibiting the binding of CARP-1 with NEMO. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/282 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/4164 (20130101) A61K 47/557 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293383 | Jung et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Michael E. Jung (Los Angeles, California); Charles L. Sawyers (New York, New York); Samedy Ouk (Los Angeles, California); Chris Tran (New York, New York); John Wongvipat (New York, New York) |
| ABSTRACT | Provided herein are hydantoin compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. Exemplary hydantoin compounds include substituted diazaspiroalkanes, such as (A51) and (A52) having the following structures: |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/375628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/48 (20130101) A61K 31/4439 (20130101) Original (OR) Class Heterocyclic Compounds C07D 401/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293398 | Disney et al. |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
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| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida); Sai Pradeep Velagapudi (Jupiter, Florida) |
| ABSTRACT | RNA drug targets are pervasive in cells but methods to design small molecules that target them are sparse. Herein, we report a general approach to score the affinity and selectivity of RNA motif-small molecule interactions identified via selection. Named High Throughput Structure-Activity Relationships Through Sequencing (HiT-StARTS), HiT-StARTS is statistical in nature and compares input nucleic acid sequences to selected library members that bind a ligand via high throughput sequencing. The approach allowed facile definition of the fitness landscape of hundreds of thousands of RNA motif-small molecule binding partners. These results were mined against folded RNAs in the human transcriptome and identified an avid interaction between a small molecule and the Dicer nuclease-processing site in the oncogenic microRNA (miR)-18a hairpin precursor, which is a member of the miR-17-92 cluster. Application of the small molecule, Targapremir-18a, to prostate cancer cells inhibited production of miR-18a from the cluster, de-repressed serine/threonine protein kinase 4 protein (STK4), and triggered apoptosis. Profiling the cellular targets of Targapremir-18a via Chemical Cross Linking and isolation by Pull Down (Chem-CLIP), a covalent small molecule-RNA cellular profiling approach, and other studies showed specific binding of the compound to the miR-18a precursor, revealing broadly applicable factors that govern small molecule drugging of non-coding RNAs. |
| FILED | Friday, February 16, 2018 |
| APPL NO | 16/486223 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 235/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293409 | Blazar et al. |
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| APPLICANT(S) | Pharmacyclics LLC (North Chicago, Illinois); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce R. Blazar (Golden Valley, Minnesota); Ryan Flynn (Minneapolis, Minnesota) |
| ABSTRACT | Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/372495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 35/28 (20130101) A61K 45/06 (20130101) A61K 2035/124 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293443 | Gordts et al. |
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| APPLICANT(S) | Philip L.S.M GORDTS (San Diego, California); Kamil Godula (La Mesa, California); Ryan Porell (La Jolla, California); Sean Cameron Purcell (San Diego, California); Greg TRIEGER (San Diego, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip L.S.M. Gordts (San Diego, California); Kamil Godula (La Mesa, California); Ryan Porell (La Jolla, California); Sean Cameron Purcell (San Diego, California); Greg Trieger (San Diego, California) |
| ABSTRACT | Described herein are compositions and methods for increasing a glucose uptake of differentiated adipocytes using heparan sulfate mimetics comprising a polymer backbone comprising sulfated di saccharides, the polymer backbone linked to a cell membrane anchoring portion, wherein the heparan sulfate mimetic associates with the cell membrane or binds to membrane surface proteins of the pre-adipocytes and the adipocytes. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 18/569174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class A61K 47/549 (20170801) A61K 47/595 (20170801) A61K 47/643 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293452 | Eruslanov et al. |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Evgeniy Eruslanov (Havertown, Pennsylvania); Steven Albelda (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally occurring container, wherein the hybrid neutrophil expresses at least one neutrophil associated molecule selected from the group consisting of: Arg1, MPO, CD66b, and CD15, and at least one antigen-presenting cell (APC) associated molecule selected from the group consisting of: CD14, HLA-DR, CD32, CD64, and CD89. In another aspect, the present invention features methods of generating a hybrid neutrophil. In still another aspect, the present invention features methods of inhibiting tumor growth in a subject, treating a tumor in a subject, and increasing efficacy of an antibody against a tumor in a subject. The methods comprise (a) administering to the subject an effective amount of an anti-tumor antibody and (b) administering to or generating in the subject an effective amount of a hybrid neutrophil. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 38/193 (20130101) A61K 38/217 (20130101) A61K 39/0011 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/599 (20130101) C12N 2502/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293461 | Lynn et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachel Lynn (Redwood City, California); Crystal Mackall (Stanford, California); Tom J. Wandless (Redwood City, California); Evan Weber (Redwood City, California) |
| ABSTRACT | The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention find use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology. |
| FILED | Wednesday, February 21, 2024 |
| APPL NO | 18/583096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5025 (20130101) A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/3084 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/90 (20130101) C12N 2501/727 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293462 | Raymond et al. |
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| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Howard Raymond (Dorchester, Massachusetts); Ahmad S. Khalil (Lexington, Massachusetts) |
| ABSTRACT | Provided herein, in various embodiments, are mammalian cells (e.g., immune effector cells) comprising a nucleotide sequence encoding an exogenous fusogen. Also provided herein, in various embodiments, are methods of treating cancer in a subject in need thereof, comprising administering to the subject mammalian cells (e.g., immune effector cells) disclosed herein. Also provided herein, in various embodiments, are methods of killing a cancer cell, comprising contacting the cancer cell with mammalian cells (e.g., immune effector cells) disclosed herein. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/593853 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/4611 (20230501) A61K 39/4632 (20230501) A61K 39/464412 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/005 (20130101) C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/1037 (20130101) C12N 2720/12222 (20130101) C12N 2720/12232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293463 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children’s Hospital DBA Seattle Children’s Research Institute (Seattle, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Tuesday, April 23, 2024 |
| APPL NO | 18/643312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293474 | DANINO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Tal DANINO (New York, New York); Kam LEONG (New York, New York); Tetsuhiro HARIMOTO (New York, New York); Jaeseung HAHN (New York, New York) |
| ABSTRACT | Programmable bacterial cells that comprise a gene that regulates capsular polysaccharide nanoencapsulation of the bacterium linked to an exogenous promoter, wherein expression of the gene and the nanoencapsulation can be programmed or controlled by an external modulator of the exogenous promoter and related compositions and methods. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498383 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293481 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New york, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New york, New York); SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, New York); MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (New York, New York); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Melody Smith (New York, New York); Marcel Van Den Brink (New York, New York); Anqi Dai (New York, New York); Sean Devlin (New York, New York); Marco Ruella (Philadelphia, Pennsylvania); Andrea Facciabene (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure relates to compositions and methods for predicting cancer survival or toxicity in a subject receiving a chimeric antigen receptor (CAR) T cell therapy. The present disclosure further discloses compositions, e.g., pharmaceutical compositions, and methods for treating said subject. |
| FILED | Monday, May 06, 2024 |
| APPL NO | 18/656397 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 35/745 (20130101) A61K 35/747 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464412 (20230501) A61K 39/464417 (20230501) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) C12Q 1/689 (20130101) C12Q 2600/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293486 | Kelly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, New Caledonia); Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Kelly (Durham, North Carolina); Patrick Seed (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are biotherapeutics comprising probiotics or a consortium of probiotics. Disclosed herein are biotherapeutics comprising factors secreted from probiotics or factors secreted from a consortium of probiotics. Disclosed herein are also pharmaceutical formulations comprising a disclosed biotherapeutic. Also disclosed are methods of promoting respiratory health, reducing the risk of developing and infection, treating and/or preventing a bacterial colonization and/or infection, and modulating microbial diversity and/or composition. |
| FILED | Friday, July 01, 2022 |
| APPL NO | 18/575412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293502 | Cadete Pires et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NovoBiotic Pharmaceuticals, LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana Cristina Cadete Pires (Cambridge, Massachusetts); Aranda Rae Duan (Medford, Massachusetts); Losee Lucy Ling (Arlington, Massachusetts) |
| ABSTRACT | The present invention provides pharmaceutical compositions of teixobactin that are capable of preventing gelation of teixobactin. The pharmaceutical compositions comprise teixobactin and a pegylated phospholipid. The present invention also provides methods of preparing the pharmaceutical compositions of teixobactin and methods of treating a subject using the pharmaceutical compositions of teixobactin. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/15 (20130101) Original (OR) Class A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293507 | SELSTED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. SELSTED (Pasadena, California); Dat Q. TRAN (Alhambra, California); Jagadish KRISHNAPPA (Aracadia, California) |
| ABSTRACT | Compositions and methods for enhancing immune checkpoint inhibitor therapy of cancer by cotherapy with cyclic peptides are provided. Such cyclic peptides can be naturally occurring or of synthetic origin. |
| FILED | Monday, May 20, 2024 |
| APPL NO | 18/669253 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1729 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) C07K 14/4723 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293509 | Sands et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Roger Sands (Sewickley, Pennsylvania); Steven R. Little (Allison Park, Pennsylvania) |
| ABSTRACT | The present disclosure relates to the use of microparticles to prevent and/or treat inflammatory bowel disease (IBD). The methods include prevention and/or treatment of IBD with the administration of the disclosed microparticles to a subject. The present disclosure further provides kits for performing such methods. |
| FILED | Friday, April 19, 2024 |
| APPL NO | 18/640662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 31/436 (20130101) A61K 38/1841 (20130101) Original (OR) Class A61K 38/2013 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293518 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuesheng ZHANG (Orchard Park, New York); Lu YANG (Buffalo, New York); Yun LI (Orchard Park, New York) |
| ABSTRACT | Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB2-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB2-positive cancer. |
| FILED | Monday, February 12, 2024 |
| APPL NO | 18/439315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4813 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 45/06 (20130101) Peptides C07K 2319/21 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Enzymes C12Y 304/13009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293529 | CROYLE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Maria A. CROYLE (Austin, Texas); Stephen Clay SCHAFER (Austin, Texas) |
| ABSTRACT | Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided. |
| FILED | Friday, May 17, 2024 |
| APPL NO | 18/667247 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/543 (20130101) A61K 2039/55555 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/88 (20130101) C12N 2710/10343 (20130101) C12N 2710/10351 (20130101) C12N 2710/10371 (20130101) C12N 2760/14134 (20130101) C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293532 | Connors |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as Represented by The Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as Represented by The Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Mark Connors (Bethesda, Maryland) |
| ABSTRACT | A replication-competent adenovirus type 4 (Ad4) modified to express the SARS-COV-2 spike protein is described. The genome of the recombinant Ad4 is modified to have a deletion of at least a portion of the adenovirus E3 region to accommodate insertion of the spike protein coding sequence. Administration of the recombinant Ad4 to the upper respiratory tract elicits mucosal immunity, which is important for protection against SARS-COV-2 infection and for preventing transmission of the virus. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 18/271901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293545 | Montell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Denise Montell (Santa Barbara, California); Abhinava K. Mishra (Santa Barbara, California); Alba Y. Torres Espinosa (Santa Barbara, California) |
| ABSTRACT | Genetically engineered activated phagocytic cells are described and related vectors, compositions, methods and systems which allow efficient cell targeting through enhanced phagocytosis of target cells and treatment of conditions in an individual. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/995083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4614 (20230501) A61K 39/4631 (20230501) A61K 39/4637 (20230501) Original (OR) Class Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 9/14 (20130101) C12N 2510/00 (20130101) C12N 2830/003 (20130101) Enzymes C12Y 306/05002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293547 | Airan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raag D. Airan (Menlo Park, California); Qian Zhong (Palo Alto, California) |
| ABSTRACT | Disclosed herein are compositions comprising polymeric perfluorocarbon nanoemulsions and methods of their production, as well as methods for their use in imaging, examination, diagnosis and/or treatment of neurological and psychiatric diseases, as well as for ultrasound-mediated localized drug release into the brain. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/381930 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/165 (20130101) A61B 5/369 (20210101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0019 (20130101) A61K 9/0085 (20130101) A61K 9/1075 (20130101) A61K 31/05 (20130101) A61K 31/135 (20130101) A61K 31/277 (20130101) A61K 31/704 (20130101) A61K 31/4174 (20130101) A61K 31/4422 (20130101) A61K 33/243 (20190101) A61K 41/0028 (20130101) Original (OR) Class A61K 47/34 (20130101) A61K 49/226 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/08 (20180101) A61P 23/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293550 | Khvorova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Matthew Hassler (Worcester, Massachusetts); Julia Alterman (Worcester, Massachusetts); Bruno Miguel da Cruz Godinho (Worcester, Massachusetts) |
| ABSTRACT | Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation. |
| FILED | Tuesday, December 26, 2023 |
| APPL NO | 18/396613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7084 (20130101) A61K 47/26 (20130101) Original (OR) Class A61K 47/55 (20170801) A61K 47/549 (20170801) A61K 47/551 (20170801) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 3/08 (20130101) C07H 21/04 (20130101) C07H 99/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/52 (20130101) C12N 2310/3513 (20130101) C12N 2310/3515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293553 | Chaikof et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Elliot Chaikof (Newton, Massachusetts); Appi Mandhapati (Boston, Massachusetts); Simon Park (Boston, Massachusetts); Richard D. Cummings (Brookline, Massachusetts) |
| ABSTRACT | Provided are novel P-selectin inhibitors, compositions and uses thereof, and methods of making thereof. |
| FILED | Thursday, September 22, 2022 |
| APPL NO | 18/693494 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293555 | Khvorova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts); CEDAES-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Ken Yamada (Westborough, Massachusetts); Vignesh Narayan Hariharan (Southborough, Massachusetts); Ananth Karumanchi (Chestnut Hill, Massachusetts) |
| ABSTRACT | This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides. The oligonucleotide is conjugated to a functional moiety comprising a carbohydrate. In certain embodiments, the carbohydrate is a glucosamine or a derivative thereof. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/537392 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/548 (20170801) A61K 47/549 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293571 | XU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PEISHENG XU (CHAPIN, South Carolina); MINGMING WANG (WEST COLUMBIA, South Carolina) |
| ABSTRACT | Disclosed are brain-targeted antibody delivery systems, methods of forming the systems, and methods of using the systems. The systems include hydrophilic nanogels based upon poly(ethylene glycol) copolymers. The nanogels can encapsulate an antibody for delivery to the brain and can include ligands for blood brain barrier (BBB) receptors on the surface, and as such, can utilize a systemic route of administration for delivery of the antibody to the brain and the eye. The systems can be utilized for systemic delivery routes to deliver the antibody to the brain side of the blood brain barrier and inside glial cells and degrade its corresponding protein. The systems can be utilized in treatment of neurodegenerative or retinal disorders. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 18/559145 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/197 (20130101) A61K 47/60 (20170801) A61K 47/6903 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293578 | Cherqui |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Cherqui (La Jolla, California) |
| ABSTRACT | Provided herein are methods for treating a disease or disorder associated with mitochondrial dysfunction through ex vivo introduction of a nucleic acid molecule into hematopoietic stem and progenitor cells (HSPCs) followed by transplantation of the HSPCs into a subject in need of treatment. The nucleic acid molecule may include a functional human frataxin (hFXN) or may include a gene editing system that when transfected into the cells removes a trinucleotide extension mutation of endogenous hFXN. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/658077 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 35/28 (20130101) A61K 48/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293581 | Hu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Hu (Menlo Park, California) |
| ABSTRACT | Compositions and methods for treating a mammalian subject for an axonopathy, including an optic nerve axonopathy, e.g. glaucoma. Aspects of the composition include a mammalian viral vector, comprising a γ-synuclein promoter, or functional fragment thereof, that promotes expression of a NMNTA2 transgene specifically in retinal ganglion cells (RGCs). Aspects of the methods include intravitreally administering the composition to treat the subject for an ON neuropathy. |
| FILED | Thursday, May 09, 2024 |
| APPL NO | 18/659959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0066 (20130101) A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 27/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 207/07001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293584 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xing Yang (Baltimore, Maryland); Sridhar Nimmagadda (Baltimore, Maryland); Steven Rowe (Parkville, Massachusetts); Stephanie Slania (Baltimore, Maryland); Martin G. Pomper (Baltimore, Maryland) |
| ABSTRACT | Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed. |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) A61K 51/0478 (20130101) A61K 51/0482 (20130101) A61K 51/0485 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293600 | Dugas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tammy R. Dugas (Baton Rouge, Louisiana); Cristina Sabliov (Baton Rouge, Louisiana); Carlos Astete (Baton Rouge, Louisiana) |
| ABSTRACT | The present disclosure provides for compositions, methods of making the composition, and devices (e.g., vascular grafts, self-expandable stents, balloon-expandable stents, and stent-grafts) having the composition disposed thereof. The composition can include a polymer nanoparticle (e.g., charged or uncharged) made of polymers that have one or more types of agents covalently bonded to the polymer. In this regard, the one or more types of agents are not physically encapsulated by the polymer, rather are covalently bonded to the polymer that makes up the polymeric nanoparticle. In another aspect, an agent can also be encapsulated in the polymer of the polymeric nanoparticle. In another embodiment, the composition includes two types of polymeric nanoparticles, where a first polymeric nanoparticle has at least one agent covalently bonded to the polymer of the first polymeric nanoparticle and where the composition can also include a second polymeric nanoparticle encapsulating an agent. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 18/571757 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 29/06 (20130101) A61L 29/16 (20130101) A61L 31/06 (20130101) A61L 31/16 (20130101) A61L 2300/416 (20130101) A61L 2300/624 (20130101) A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293759 | Andrews et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Velico Medical, Inc (Beverly, Massachusetts) |
| ASSIGNEE(S) | Velico Medical, Inc. (Beverly, Massachusetts) |
| INVENTOR(S) | Robert R. Andrews (Norfolk, Massachusetts); Herman E. Snyder (W. Lafayette, Indiana); William J. Merritt (Danvers, Massachusetts); Kyle D. Erickson (Melrose, Massachusetts); Evan P. Ordway (Salem, Massachusetts); Clair Strohl (Emmaus, Pennsylvania); Russell Barron (Boston, Massachusetts) |
| ABSTRACT | The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650263 |
| CURRENT CPC | Separation B01D 1/18 (20130101) Original (OR) Class Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293806 | Zhao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhao (Ames, Iowa) |
| ABSTRACT | The disclosure relates to molecularly-imprinted cross-linked micelles that can selectively hydrolyze carbohydrates. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/636070 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/067 (20130101) Original (OR) Class B01J 35/23 (20240101) B01J 37/04 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294478 | Herzon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Herzon (New Haven, Connecticut); Ranjit Bindra (New Haven, Connecticut); Kingson Lin (New Haven, Connecticut) |
| ABSTRACT | Disclosed are compounds having anti-cancer activity, as well as methods of using these compounds. In some instances, the compounds are useful for treating, ameliorating, and/or preventing MGMT-deficient cancers and/or MMR-deficient cancers. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/571471 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4164 (20130101) A61K 31/4188 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 233/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294481 | TIEU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kim TIEU (Miami, Florida); Adel NEFZI (Miami, Florida); Stephen BLACK (Miami, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida) |
| INVENTOR(S) | Kim TIEU (Miami, Florida); Adel NEFZI (Miami, Florida); Stephen BLACK (Miami, Florida) |
| ABSTRACT | The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders. |
| FILED | Tuesday, February 06, 2024 |
| APPL NO | 18/433879 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/16 (20180101) Heterocyclic Compounds C07D 277/42 (20130101) Original (OR) Class C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294493 | Liotta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Liotta (Atlanta, Georgia); Stephen Traynelis (Decatur, Georgia); Yao Jing (Dunwoody, Georgia) |
| ABSTRACT | A compound according to Formula (I) or salts or prodrugs thereof and pharmaceutical formulations comprising the compound are provided herein for the treatment of neurological disorders. The disorders may include providing neuroprotection, preventing neurodegeneration, treating neuropathic pain or treating schizophrenia, psychoses or depression. Furthermore, the compounds may be used in combination with another active ingredient. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/650059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/497 (20130101) A61K 31/4155 (20130101) A61K 31/4709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/18 (20180101) A61P 25/24 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 231/06 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/04 (20130101) C07D 409/04 (20130101) C07D 409/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294503 | Topczewski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Joseph J. Topczewski (Minneapolis, Minnesota); William C.K. Pomerantz (Minneapolis, Minnesota); Angela S. Carlson (Minneapolis, Minnesota); Huarui Cui (Minneapolis, Minnesota); Anand Divakaran (Minneapolis, Minnesota) |
| ABSTRACT | The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors. |
| FILED | Thursday, April 18, 2024 |
| APPL NO | 18/639608 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294513 | Moghadam |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 712 North Inc. (Oakland, California) |
| ASSIGNEE(S) | 712 North Inc. (Oakland, California) |
| INVENTOR(S) | Marcel Victor Alavi Khorassani Moghadam (Berkeley, California) |
| ABSTRACT | Means and methods for therapeutic intervention of mitochondrial disorders or diseases, and in particular to a method for the treatment, prevention and/or amelioration of a disorder or disease correlated with mitochondrial stress or dysfunction, a mitochondrial disorder or disease, or a disorder or disease characterized by OPA1 alterations. Thereby, a pharmaceutically active amount of a compound capable of modulating the activity of OMA1 and/or an oligomeric complex of OMA1 is administered to a patient in need of medical intervention. Methods of screening for a compound capable of modulating the activity of OMA1 and/or an oligomeric complex comprising OMA1 are performed. Methods for determining the susceptibility for, predisposition for, or the presence of such a disorder or disease and whether a person in need will benefit from the therapeutic intervention, i.e., personalized medicine are also performed. |
| FILED | Tuesday, April 23, 2024 |
| APPL NO | 18/642913 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0073 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294552 | MacNevin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NIRvana Sciences Inc. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J MacNevin (Durham, North Carolina) |
| ABSTRACT | Provided are bacteriochlorin hydroporphyrin compounds that contain a single site for conjugation that includes a beta-pyrrole linker. Also provided are methods for producing the same and for using the same for diagnosis and/or therapy. The disclosed compounds are characterized by improved solubility and photophysical characteristics, including but not limited to improved absorption spectrum, emission spectrum, and brightness of fluorescence relative to benchmark bacteriochlorin hydroporphyrin compounds that lack the beta-pyrrole linker. |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 18/571684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0071 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294555 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Peyton Shieh (Cambridge, Massachusetts); Wenxu Zhang (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits. |
| FILED | Tuesday, January 02, 2024 |
| APPL NO | 18/401860 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) A61K 45/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0834 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/06 (20130101) C08G 2261/126 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) C08L 83/04 (20130101) C08L 2201/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294570 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts); HEBECELL CORP. (Natick, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuang LIU (Waltham, Massachusetts); Shijiang LU (Shrewsbury, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | An isolated peptide having the structure: where —NH-Q-C(O)— is an α-helical amino acid sequence that includes at least 4 and up to 30 amino acid residues, Z1 is a moiety including an aromatic group or a fluorophore, Z2 includes a phosphorylated amino acid residue, or the dephosphorylated amino acid residue. These peptides, in dephosphorylated form, are capable of self-assembly in the form of a nanoribbon, nanofiber, or a combination thereof. Such peptides are capable of causing cell death of cells that overexpress alkaline phosphatases, which includes cancer cells and induced pluripotent stem cells (iPSCs), and therefore the peptides of the invention can be used ex vivo to selectively cause cell death of cancer cells or iPSCs, or in vivo to cause cancer cell death. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 38/00 (20130101) Peptides C07K 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294571 | BHATTACHARJEE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arindam BHATTACHARJEE (Buffalo, New York) |
| ABSTRACT | Disclosed are agents and methods of using the agents to treat or prevent pain and/or induce anesthesia. The agents may be peptides, siRNAs, and/or shRNAs that target adaptin protein 2-clathrin mediated endocytosis (AP2-CME). Peptides of the present disclosure may contain the following sequence X1X2X3X4LX5 (SEQ ID NO:7), where X1 is D, E, S, or T, where the D, E, S, and/or the T is optionally phosphorylated, X2, X3, and X3 are independently chosen from any amino acid. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/768142 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) A61P 29/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294573 | Gadek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TearSolutions, Inc. (Charlottesville, Virginia); The University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas R. Gadek (Park City, Utah); Paul A. Laskar (Napa, California); Gordon W. Laurie (Charlottesville, Virginia) |
| ABSTRACT | This application generally relates to constrained salts of peptides, constrained forms of peptides, and compositions, kits, methods of using, or uses of the same. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/620550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0048 (20130101) A61K 38/00 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) Peptides C07K 7/08 (20130101) C07K 14/001 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294574 | Walensky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loren D. Walensky (Newton, Massachusetts); Gregory H. Bird (Pelham, New Hampshire) |
| ABSTRACT | Provided herein is a platform technology for designing stabilized peptides that covalently bind their target protein and thereby inhibit the activity of the target protein. Also provided are exemplary stabilized peptides that can be used for covalent modification of their target proteins. |
| FILED | Tuesday, April 25, 2023 |
| APPL NO | 18/306724 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/001 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/6803 (20130101) G01N 33/6845 (20130101) G01N 2030/8831 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294576 | Asokan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Aravind Asokan (Durham, North Carolina); Zachary Elmore (Durham, North Carolina); Lawrence Patrick Havlik (Durham, North Carolina); Daniel K. Oh (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are compositions and methods for enhancing secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for altering and/or modifying the formation and/or secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for loading extracellular vesicles and or AAV particles with a cargo. Disclosed herein are isolated nucleic acid molecules encoding a polypeptide for promoting the formation of extracellular vesicles and AAV particles in cell or a polypeptide associated with extracellular vesicles and/or AAV particles secreted from a cell. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/919997 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 47/64 (20170801) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294581 | Crawford et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Crawford (Shelton, Connecticut); Jhe-Hao Li (New Haven, Connecticut); Joonseok Oh (New Haven, Connecticut) |
| ABSTRACT | The present disclosure includes a construct comprising a leupeptin biosynthesis operon, the operon comprising leupA, leupB, leupC, and leupD genes operably linked to a promoter. Also included are cells comprising the construct, and methods for production of leupeptin peptidc. |
| FILED | Wednesday, January 24, 2024 |
| APPL NO | 18/421303 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294587 | Iijima et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miho Iijima (Balitmore, Maryland); Hiroshi Senoo (Baltimore, Maryland); Hiromi Sesaki (Baltimore, Maryland) |
| ABSTRACT | The present disclosure provides peptide inhibitors of K-Ras, and polynucleotides, compositions, and methods of use thereof. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 18/551557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294595 | Polt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Torsten A E Falk (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); John Streicher (Tucson, Arizona) |
| ABSTRACT | Glycopeptides comprising a peptide that is covalently linked to a saccharide. The peptide portion of the glycopeptides of the invention has from about 20 to about 40 amino acid residues and at least 75% sequence identity to SEQ ID NO:5. The saccharide moiety portion of the glycopeptides of the present invention comprises from 1 to about 8 carbohydrates. The present invention also relates to using the glycopeptides of the invention in treating various neurodegenerative diseases. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/530028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/57563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294613 | Xavier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramnik Xavier (Cambridge, Massachusetts); Johannes Scheid (Boston, Massachusetts); Christopher Barnes (Pasadena, California); Pamela Bjorkman (Pasadena, California); Basak Eraslan (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides for cross-neutralizing SARS-COV2 antibodies. The antibodies can be used to treat SARS-CoV2 and variants thereof. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 18/270131 |
| CURRENT CPC | Peptides C07K 16/1003 (20230801) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/51 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294615 | SHAUGHNESSY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jutamas SHAUGHNESSY (Carlisle, Massachusetts); Peter A. RICE (Southborough, Massachusetts); Sunita GULATI (Spencer, Massachusetts); Sanjay RAM (Worcester, Massachusetts); Celia SCHIFFER (Boston, Massachusetts) |
| ABSTRACT | Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/408793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1217 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) C07K 2317/734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294618 | Glanville et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Centivax, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob E. Glanville (San Francisco, California); Timothy Paul Friede (Green Bay, Wisconsin); David Tsao (Sunnyvale, California); Sindy Andrea Liao Chan (San Jose, California); I-Chieh Wang (San Bruno, California) |
| ABSTRACT | This disclosure provides antibodies and antigen-binding fragments that can be administered to a subject that has been bitten by a venomous snake. Antibodies and antigen-binding fragments herein can be capable of treating or curing the subject and may provide protection against snake venom for up to several weeks. A combination or population of antibodies and antigen-binding fragments can be administered to the subject where the type of snake is not known or where a subject has been bitten by more than one species of snake. This disclosure further provides methods for identification of such broadly-neutralizing antibodies. |
| FILED | Wednesday, October 04, 2023 |
| APPL NO | 18/481129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6857 (20130101) G01N 2333/4616 (20130101) G01N 2333/4646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294636 | Eichmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne Eichmann (Branford, Connecticut); Kevin Boyé (New Haven, Connecticut); Laurence Pibouin-Fragner (Boulogne-Billancourt, France); Luiz Geraldo (New Haven, Connecticut) |
| ABSTRACT | The present disclosure relates to antibodies and binding polypeptides specific for mouse, human, and rat Uncoordinated 5B (Unc5B) protein for use in generating temporary permeability of the blood brain barrier. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/573775 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/2803 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294639 | Sadelain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (Bethesda, Maryland) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (Bethesda, Maryland) |
| INVENTOR(S) | Michel Sadelain (New York, New York); Reuben Benjamin (London, United Kingdom); Dimiter S. Dimitrov (Frederick, Maryland); Yang Feng (Frederick, Maryland) |
| ABSTRACT | The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity. |
| FILED | Monday, May 13, 2024 |
| APPL NO | 18/662315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/30 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294648 | Hsiue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Han-Chung Hsiue (Baltimore, Maryland); Qing Wang (Owings Mills, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Frankford, Delaware); Shibin Zhou (Owings Mills, Maryland); Jacqueline Douglass (Baltimore, Maryland); Michael S. Hwang (Seattle, Washington); Nickolas Papadopoulos (Towson, Maryland) |
| ABSTRACT | This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided. |
| FILED | Monday, September 25, 2023 |
| APPL NO | 18/473695 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/2809 (20130101) C07K 16/2833 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294657 | Deb |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | In certain aspects, provided herein are inhibitory anti-ENPP1 antibodies and antigen binding fragments thereof. In some aspects, provided herein are methods of treating myocardial infarction using the antibodies provided herein. In certain aspects, provided herein are nucleic acid molecules encoding the antibodies provided herein, host cells comprising such nucleic acids, and methods of making the antibodies provided herein using such host cells. In some aspects, also provided herein are pharmaceutical compositions comprising the antibodies provided herein. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/384176 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294665 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (, None) |
| INVENTOR(S) | Qiong J. Wang (Highland Park, New Jersey); Zhiya Yu (Potomac, Maryland); James C. Yang (Bethesda, Maryland) |
| ABSTRACT | The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/7153 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2875 (20130101) C07K 2317/60 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294670 | JU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Cynthia JU (Bellaire, Texas); Jongmin JEONG (Houston, Texas); Zhao SHAN (Houston, Texas); Leike LI (Houston, Texas); Ningyan AN (Houston, Texas); Zhiqiang AN (Houston, Texas) |
| ABSTRACT | Provided herein are antibodies binding to CHI3L1 and the uses of the antibodies in detecting and treating cancer and for treating hepatotoxicity. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/996854 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/4631 (20230501) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2239/13 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/11 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294760 | Wagner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Wagner (Gibsonia, Pennsylvania); Sang Ho Ye (Cheswick, Pennsylvania); Seungil Kim (Pittsburgh, Pennsylvania); Sung Kwon Cho (Pittsburgh, Pennsylvania) |
| ABSTRACT | A zwitterionic polysiloxane polymer (e.g., a polyurethane elastomer) composition having poly(dialkylsiloxane) blocks and a zwitterionic moiety is prepared by the copolymerization of a poly(dialkylsiloxane) diol, a diisocyanate, a tertiary amine alkyl diol, and a poly(dialkylsiloxane) diamine to form a poly(urethane urea) copolymer. A substituted saturated heterocylic compound is reacted with the tertiary amine of the poly(urethane urea) copolymer to introduce a zwitterionic group into the poly(urethane urea) copolymer backbone. A polysiloxane polymer having a zwitterionic moiety is prepared by reacting a diallyl tertiary amine compound and a substituted saturated heterocylic compound to form a diallyl zwitterionic macromer and cross-linking a vinyl terminated poly(dialkylsiloxane) and the diallyl zwitterionic macromer with a curing agent to introduce a zwitterionic group into the poly(dialkylsiloxane) polymer. |
| FILED | Wednesday, May 01, 2024 |
| APPL NO | 18/651748 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/06 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294890 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts) |
| ABSTRACT | This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed. |
| FILED | Monday, April 29, 2024 |
| APPL NO | 18/649077 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 48/005 (20130101) Peptides C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2320/10 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294900 | Sette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California); J. Craig Venter Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alessandro Sette (La Jolla, California); Alba Grifoni (La Jolla, California); Alison Tarke (La Jolla, California); Yun Zhang (San Diego, California); Richard Scheuerman (La Jolla, California) |
| ABSTRACT | The present invention includes compositions and methods for detecting the presence of: a coronavirus or an immune response relevant to a coronavirus infection including T cells responsive to one or more coronavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative thereof; a fusion protein comprising one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); a pool of 2 or more peptides selected from the amino acid sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); or a polynucleotide that encodes one or more peptides or proteins, comprising, consisting of, or consisting essentially of an amino acid sequence selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative thereof. The invention further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides. |
| FILED | Wednesday, January 03, 2024 |
| APPL NO | 18/403239 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class C12N 15/1055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294919 | BASU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KENT STATE UNIVERSITY (Kent, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soumitra BASU (Hudson, Ohio); Nathan BEALS (Streetsboro, Ohio); Mohamed M. FARHATH (Dehiwala, Sri Lanka); Prakash KHAREL (Jamaica Plain, Massachusetts) |
| ABSTRACT | Novel DNA molecule-based compositions and methods for delivery to target cells provide modulation of target G-quadruplex formation in the tyrosine hydroxylase (TH) promoter and allow for enhancement or repressing of specific G-quadruplexes that in turn regulate tyrosine hydroxylase transcription and catecholamine production, specifically dopamine. Use of the DNA-molecule-based compositions in treatment of neurological diseases and disorders is facilitated through a nanoparticle-based delivery system. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 18/563140 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6923 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/151 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) Enzymes C12Y 114/16002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294939 | Church et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Prashant G. Mali (La Jolla, California); Luhan Yang (Somerville, Massachusetts) |
| ABSTRACT | A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663233 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/01 (20130101) C12N 15/10 (20130101) C12N 15/63 (20130101) C12N 15/81 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 15/1024 (20130101) C12N 15/8201 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) C12N 2810/55 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294941 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Lili Wang (Phoenixville, Pennsylvania); Qiang Wang (Philadelphia, Pennsylvania) |
| ABSTRACT | Use of a rAAV3B vector to deliver gene products to human hepatocytes is described. The rAAV3B vectors achieve high levels of transduction even in the presence of pre-existing immunity to AAV8 or AAVrh10. Compositions and treatment regimens are described. Also provided are rAAV engineered to facilitate purification and methods of purifying the AAV. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/761 (20130101) A61K 48/0058 (20130101) Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) C12N 2750/14151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294962 | ROMESBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Vivian T. DIEN (San Diego, California); Aaron W. FELDMAN (San Diego, California); Rebekah J. KARADEEMA (San Diego, California); Lingjun LI (Xinxiang, China PRC); Michael P. LEDBETTER (Jamaica Plain, Massachusetts); Anne Xiaozhou ZHOU (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532609 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/24 (20130101) C07H 21/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294965 | OKERBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Eric OKERBERG (San Diego, California); Kevin L. Gunderson (Encinitas, California); Norihito Muranaka (San Diego, California); Jongbum Kim (San Diego, California); Byung Joon Lim (Seoul, South Korea); Lei Shi (San Diego, California); Soumya Ganguly (San Diego, California); Devin Sullivan (San Diego, California) |
| ABSTRACT | Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/658862 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2458/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294978 | Lindsay |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (SCOTTSDALE, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (SCOTTSDALE, Arizona) |
| ABSTRACT | The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer. |
| FILED | Wednesday, February 14, 2024 |
| APPL NO | 18/441809 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) G01N 33/48721 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/20 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294980 | Gundlach et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Andrew Laszlo (Seattle, Washington) |
| ABSTRACT | The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety. The disclosure also provides a method of increasing the interaction rate between a polymer analyte and a nanopore, wherein the polymer analyte contains an end domain that has at least one charged moiety. The disclosure also provide compositions for use with the described methods, including adapter compositions that contain charged moieties, such as phosphate or sulfate groups, and that are configured to being linked to an polymer analyte domain. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/486061 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294983 | Schulte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel J Schulte (Pasadena, California); Niles A Pierce (Pasadena, California) |
| ABSTRACT | The present application relates to hybridization chain reaction (HCR). In particular, the sensitivity of hybridization chain reaction (HCR) signal amplification is combined with two or more fractional-initiator probes and one or more proximity probes able to colocalize a full HCR initiator that will trigger HCR when the targets are in proximity to one another. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/592402 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294986 | Niculescu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana Universityh Research and Technology Corporation (Bloomington, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are novel compounds for treating and preventing schizophrenia, and more generally psychosis, by bioinformatics drug repurposing using novel genes expression biomarkers involved in psychotic symptoms (delusions, hallucinations); methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for psychosis in a subject; and method of using repurposed drugs and natural compounds to prevent and to treat psychosis. Methods are disclosed using a universal approach, in everybody, as well as personalized approaches by gender. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females). Methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms. The algorithms combine biomarkers as well as clinical measures for psychosis, to identify subjects who are at risk of psychosis, and to track responses to treatments. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570890 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295070 | YATES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Matthew Z. YATES (Fairport, New York); Benjamin L. MILLER (Penfield, New York); Jeffrey W. BEARD (Greece, New York) |
| ABSTRACT | The invention provides articles of manufacture having a surface of a boronic acid-containing siloxane polymer bonded to a cellulose-containing material. The invention further provides methods of making such articles of manufacture. The surface of the cellulose-containing material covered by the bonded boronic acid-containing siloxane polymer is hydrophobic and keeps water from soaking into the article of manufacture. In some embodiments, the invention provides analytic devices in which a hydrophobic coating is applied to a material to defining one or more channels. The one or more channels may contain reagents that can react with analytes if the analytes are present in fluids introduced into the one or more channels. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/574021 |
| CURRENT CPC | Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 15/643 (20130101) Original (OR) Class D06M 2200/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295497 | Lucente et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Mark E. Lucente (Austin, Texas); John Bruno (Kyle, Texas); Andrew Foley (Austin, Texas) |
| ABSTRACT | A method and system for determining the presence of a selected analyte in a sample include an all-dielectric, metasurface sensor having one or more arrays of subwavelength-scale, dielectric nanopillars having anisotropic cross-sections. Nanopillars in selected regions of the metasurface sensor may be functionalized with binders for selectively binding the selected analyte. Methods for detecting the selected analyte in a sample rely on exposing the sensor to a test sample, probing the sensor with probe light having a selected polarization state, and comparing the polarization state of output light reflected or transmitted by functionalized regions of the sensor with a baseline polarization state of output light determined with a sample lacking the selected analyte. |
| FILED | Thursday, February 29, 2024 |
| APPL NO | 18/591411 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) G01N 21/6445 (20130101) Original (OR) Class G01N 2021/0181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295544 | McDevitt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Glads (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd C. McDevitt (San Francisco, California); Bruce Conklin (San Francisco, California); Melanie Ott (Mill Valley, California); Juan Perez-Bermejo (San Francisco, California); Michael Sungwon Kang (San Francisco, California); Sarah Rockwood (Kensington, California); Camille Simoneau (San Francisco, California); Gokul Ramadoss (Oakland, California); David Joy (Oakland, California) |
| ABSTRACT | Provided herein are methods and compositions useful for identifying compounds that can inhibit SARS-CoV-2 infection or the effects thereof, especially in cardiomyocytes (CMs), which are highly infectible by SARS-CoV-2 corona viruses. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 18/022428 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5035 (20130101) G01N 33/5061 (20130101) Original (OR) Class G01N 33/6887 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295552 | Duffy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Quanterix Corporation (Billerica, Massachusetts) |
| ASSIGNEE(S) | Quanterix Corporation (Billerica, Massachusetts) |
| INVENTOR(S) | David C. Duffy (Arlington, Massachusetts); David M. Rissin (Lexington, Massachusetts); David R. Walt (Boston, Massachusetts); David Fournier (Northborough, Massachusetts); Cheuk Kan (Waltham, Massachusetts) |
| ABSTRACT | The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components. |
| FILED | Monday, April 22, 2024 |
| APPL NO | 18/642104 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) G01N 33/54313 (20130101) G01N 33/54393 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295620 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| INVENTOR(S) | Xiaohong Joe Zhou (Naperville, Illinois); Kaibao Sun (Chicago, Illinois) |
| ABSTRACT | The present disclosure provides technologies that allow reduced field of view or fast imaging with reduced image distortion. The first technique capitalizes on the benefit of reduced field of view imaging for full field of view coverage. The second technique allows achieves high resolution 3D images in a focused region. These techniques are expected to have applications for cancer imaging, neuro imaging, and other biomedical imaging areas. |
| FILED | Monday, June 27, 2022 |
| APPL NO | 18/573518 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) G01R 33/4822 (20130101) G01R 33/4835 (20130101) Original (OR) Class G01R 33/4836 (20130101) G01R 33/5611 (20130101) G01R 33/5616 (20130101) G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296910 | Demirtas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Demirtas (Bursa, Turkey); Przemyslaw Radwanski (Columbus, Ohio) |
| ABSTRACT | Systems and methods for identification of ion channels are described herein. In some implementations, the techniques described herein relate to a computer-implemented method including: receiving a single channel activity signal associated with an ion channel of a cell; performing a time-domain analysis on the single channel activity signal; and identifying, based on the time-domain analysis, an isoform of the ion channel. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442501 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/44 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296914 | Ekins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Collaborations Pharmaceuticals, Inc. (Fuquay Varina, North Carolina) |
| ASSIGNEE(S) | Collaborations Pharmaceuticals, Inc. (Fuquay Varina, North Carolina) |
| INVENTOR(S) | Sean Ekins (Fuquay Varina, North Carolina); Kushal Batra (Raleigh, North Carolina); Maggie Anne Hupcey (Fuquay Varina, North Carolina); Fabio Lee Urbina (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems, and computer readable media for predicting a spectrum, e.g., a UV-Vis spectrum, of a target molecule are disclosed. According to one aspect, a descriptor, such as a SMILES sequence or extended connectivity fingerprint, of the target molecule can be provided or generated and analyzed via a trained machine learning model, such as a trained long-short term memory (LSTM) model, to predict the spectrum of the target molecule. As determined via a variety of statistical measures, the methods, systems and computer readable media can predict the complete UV spectrum of a target molecule with high accuracy over the entire spectrum. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 18/272982 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201) G16C 20/30 (20190201) Original (OR) Class G16C 20/70 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296928 | Gaweda et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Adam E. Gaweda (Jeffersonville, Indiana); Michael E. Brier (Rossville, Tennessee); George R. Aronoff (Englewood, Colorado); Alfred A. Jacobs (Louisville, Kentucky) |
| ABSTRACT | A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663322 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class G16H 50/20 (20180101) G16H 50/50 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296952 | Ouyang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | David Ouyang (Los Angeles, California); Lauri Holmstrom (Los Angeles, California); Matthew Kai Christensen (Los Angeles, California) |
| ABSTRACT | A method for analyzing kidney health in an individual comprises receiving data associated with one or more cardiac characteristics of the individual; inputting the data associated with the one or more cardiac characteristics of the individual into a machine learning model; and receiving an output from the machine learning model indicative of the kidney health of the individual. The output of the machine learning model can include an indication of the presence of chronic kidney disease (CKD) in the individual or an indication of the absence of CKD in the individual. The indication of the presence of CKD in the individual can include an indication of the CKD stage of the individual, which may include mild CKD, moderate-severe CKD, or end-stage renal disease ESRD). |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/595237 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/36 (20210101) A61B 5/0245 (20130101) A61B 5/353 (20210101) A61B 5/355 (20210101) A61B 5/366 (20210101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) Original (OR) Class G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20240293240 | PERRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Christopher PERRY (Manchester, New Hampshire); Keith D. VIOLLETTE (Sandown, New Hampshire); Grant A. PERET (Bedford, New Hampshire); David D.B. CANNAN (Manchester, New Hampshire); Christopher C. LANGENFELD (Nashua, New Hampshire); Jacob P. LAPLANTE (Manchester, New Hampshire); Thomas A. DOYON (Manchester, New Hampshire) |
| ABSTRACT | A prosthetic device. The prosthetic device may include a flexure cut and/or a sensor to detect movement in accordance with a degree of movement. In an embodiment, the sensor may be disposed within the flexure cut. Other embodiments include at least one wire configured to connect a sensor located in a distal portion to a proximal portion, while annularly traversing a joint. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/658227 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/50 (20130101) A61F 2/54 (20130101) A61F 2/70 (20130101) A61F 2/76 (20130101) Original (OR) Class A61F 2/586 (20130101) A61F 2002/704 (20130101) A61F 2002/5072 (20130101) A61F 2002/6863 (20130101) A61F 2002/7615 (20130101) A61F 2002/7635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293452 | Eruslanov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evgeniy Eruslanov (Havertown, Pennsylvania); Steven Albelda (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally occurring container, wherein the hybrid neutrophil expresses at least one neutrophil associated molecule selected from the group consisting of: Arg1, MPO, CD66b, and CD15, and at least one antigen-presenting cell (APC) associated molecule selected from the group consisting of: CD14, HLA-DR, CD32, CD64, and CD89. In another aspect, the present invention features methods of generating a hybrid neutrophil. In still another aspect, the present invention features methods of inhibiting tumor growth in a subject, treating a tumor in a subject, and increasing efficacy of an antibody against a tumor in a subject. The methods comprise (a) administering to the subject an effective amount of an anti-tumor antibody and (b) administering to or generating in the subject an effective amount of a hybrid neutrophil. |
| FILED | Friday, February 02, 2024 |
| APPL NO | 18/431638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 38/193 (20130101) A61K 38/217 (20130101) A61K 39/0011 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/599 (20130101) C12N 2502/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293474 | DANINO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Tal DANINO (New York, New York); Kam LEONG (New York, New York); Tetsuhiro HARIMOTO (New York, New York); Jaeseung HAHN (New York, New York) |
| ABSTRACT | Programmable bacterial cells that comprise a gene that regulates capsular polysaccharide nanoencapsulation of the bacterium linked to an exogenous promoter, wherein expression of the gene and the nanoencapsulation can be programmed or controlled by an external modulator of the exogenous promoter and related compositions and methods. |
| FILED | Tuesday, October 31, 2023 |
| APPL NO | 18/498383 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293822 | GLEZER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eli N. GLEZER (Del Mar, California); Stephen HIGGINS (Gaithersburg, Maryland); Sandor KOVACS (Middletown, Delaware); Sudeep KUMAR (Hackettstown, New Jersey); Kenneth PAGE (Martinsburg, West Virginia); Kristian ROTH (Gaithersburg, Maryland); George SIGAL (Rockville, Maryland) |
| ABSTRACT | Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436879 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 7/525 (20130101) Original (OR) Class B01L 2200/10 (20130101) B01L 2200/16 (20130101) B01L 2200/027 (20130101) B01L 2200/146 (20130101) B01L 2200/0605 (20130101) B01L 2200/0621 (20130101) B01L 2200/0631 (20130101) B01L 2300/087 (20130101) B01L 2300/0645 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0883 (20130101) B01L 2400/0487 (20130101) B01L 2400/0688 (20130101) B01L 2400/0694 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293870 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sentient Science Corporation (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingfu LIU (Prior Lake, Minnesota); Behrooz JALALAHMADI (Long Island City, New York); Ziye LIU (West Lafayette, Indiana); Andrew VECHART (Minnetrista, Minnesota); Xiawa WU (Erie, Pennsylvania) |
| ABSTRACT | A system and method of additive manufacturing is disclosed herein which when run or performed form a product with a powder-based additive manufacturing device by adding sequential layers of material on top of one another. As each sequential layer of material is added, the system and method can include monitoring the sequential layer with a defect analysis subsystem to detect whether the sequential layer has any defects. For a detected defect, it can be determined whether defect correction is required. For a required defect correction, one or more correction parameters for the required defect correction can be identified; and a correction command including the one or more correction parameters can be sent to the additive manufacturing device, the correction command causing the additive manufacturing device to help correct the detected defect in the sequential layer according to the correction parameters prior to moving on to a next sequential layer. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/450018 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0093 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) Image Data Processing or Generation, in General G06T 7/001 (20130101) G06T 2207/10048 (20130101) G06T 2207/30136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294246 | Shundo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Ken Shundo (Fort Worth, Texas); Ryan Smith (Fort Worth, Texas); Bryan Baskin (Arlington, Texas); Hassan Mughal (Frisco, Texas) |
| ABSTRACT | A spindle bearing assembly for a rotor blade, the assembly having a shaft extending from a hub and a housing for coupling the blade to the shaft. A ring is coaxial with the shaft and has a wall with a tapered external surface that narrows toward the outboard direction. The ring can be axially translated adjacent a tapered internal surface of the housing that also narrows toward the outboard direction. A spindle bearing coaxial with the shaft has a central aperture through which the shaft extends, the spindle bearing extending between the wall and the shaft. Threaded fasteners couple the ring to the housing, and rotation of the fasteners in a selected direction causes axial translation of the ring in the outboard direction, the engagement of the tapered surfaces causing the wall to move radially inward for creating an interference fit between the spindle bearing and the wall. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176899 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/06 (20130101) Original (OR) Class B64C 29/0033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294270 | O'Donnell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher O'Donnell (Hill AFB, Utah); Justin Platt (Roy, Utah) |
| ABSTRACT | A cover for the data ports disposed on opposite sides of a F-35 aircraft. The cover is macroscopically planar when not in use but flexible to conform to the curves on the sides of the F-35 airframe when the cover is attached. The cover is magnetically attached to three sides of a frame circumscribing air data port, but not attached on the forward side of the frame. This geometry provides for a covers which are symmetric and therefore usable with air data ports on both sides of the F-35 aircraft. The air data port cover does not have mechanical attachments or parts separable in use. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176758 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294616 | Mauzy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Camilla A. Mauzy (Enon, Ohio); Serge Victor Marie Muyldermans (Brussels, Belgium) |
| ABSTRACT | Single-domain antibodies (SAbs) against three Yersinia pestis surface proteins (LcrV, YscF, and F1), nucleic acid sequences encoding the SAbs, and polypeptides comprising two or more SAbs capable of recognizing two or more epitopes and/or antigens. The present invention further includes methods for preventing or treating Y. pestis infections in a patient; methods for detecting and/or diagnosing Y. pestis infections; and devices and methods for identifying and/or detecting Y. pestis on a surface and/or in an environment. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663247 |
| CURRENT CPC | Peptides C07K 16/1228 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294657 | Deb |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | In certain aspects, provided herein are inhibitory anti-ENPP1 antibodies and antigen binding fragments thereof. In some aspects, provided herein are methods of treating myocardial infarction using the antibodies provided herein. In certain aspects, provided herein are nucleic acid molecules encoding the antibodies provided herein, host cells comprising such nucleic acids, and methods of making the antibodies provided herein using such host cells. In some aspects, also provided herein are pharmaceutical compositions comprising the antibodies provided herein. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/384176 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294665 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (, None) |
| INVENTOR(S) | Qiong J. Wang (Highland Park, New Jersey); Zhiya Yu (Potomac, Maryland); James C. Yang (Bethesda, Maryland) |
| ABSTRACT | The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/7153 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2875 (20130101) C07K 2317/60 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294754 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio); Bingqian Zheng (Miamisburg, Ohio); Hilmar Koerner (Beavercreek, Ohio); Christopher A. Crouse (Waynesville, Ohio) |
| ABSTRACT | A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623497 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294813 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio); Bingqian Zheng (Miamisburg, Ohio); Hilmar Koerner (Beavercreek, Ohio); Christopher A. Crouse (Waynesville, Ohio) |
| ABSTRACT | A family of low-molecular-weight, main-chain thermotropic liquid-crystalline polyimides (TLC-PI) that are crosslinkable is disclosed. These all-aromatic TLC-PI are derived from (i) wholly aromatic and flexible diamine monomers, in which the linkage between the two aniline-ends contains a relatively high heat-tolerant but flexible chain constituted by two or more units of 1,4-phenoxy or 1,3-phenoxy or in combinations of both. Processes of making and using such all-aromatic TLC-PI is also provided. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623511 |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/00 (20130101) C09J 179/085 (20130101) Original (OR) Class C09J 2400/10 (20130101) C09J 2400/14 (20130101) C09J 2400/16 (20130101) C09J 2400/20 (20130101) C09J 2479/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294867 | Hashemi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Nastaran Hashemi (Ames, Iowa); Reza Montazami (Ames, Iowa); Marilyn Christine McNamara (Ames, Iowa); Jasmin Okuzono (Ames, Iowa) |
| ABSTRACT | Various embodiments disclosed relate to conductive graphene matrix-encapsulated cells. A matrix-encapsulated cell includes an encapsulating polymer matrix including a biopolymer and graphene. The matrix-encapsulated cell also includes one or more of the cells encapsulated within the encapsulating polymer, wherein the graphene directly contacts at least some of the cells. The matrix encapsulating the one or more cells is electrically conductive. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/658021 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/19 (20170801) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294928 | GRUND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CureVac SE (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac SE (Tübingen, Germany) |
| INVENTOR(S) | Stefanie GRUND (Stuttgart, Germany); Thomas SCHLAKE (Gundelfingen, Germany) |
| ABSTRACT | The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-UTR element) and/or at least one 5′-untranslated region element (5′-UTR element), wherein the at least one 3′-UTR element and/or the at least one 5′-UTR element prolongs and/or increases protein production from said artificial nucleic acid molecule and wherein the at least one 3′-UTR element and/or the at least one 5′-UTR element is derived from a stable mRNA. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, methods for identifying a 3′-UTR element and/or a 5′-UTR derived from a stable mRNA element are disclosed. |
| FILED | Wednesday, January 17, 2024 |
| APPL NO | 18/415477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/68 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2830/50 (20130101) C12N 2840/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294963 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Jewett (Evanston, Illinois); Weston K. Kightlinger (Evanston, Illinois); Milan Mrksich (Evanston, Illinois); Liang Lin (Evanston, Illinois) |
| ABSTRACT | Disclosed are compositions, systems, and methods for synthesizing glycoproteins or recombinant glycoprotein protein in vitro and in vivo. In particular, the present invention relates to modified N-glycosyltransferases (NGTs), method for generating modified NGTs, methods for identifying and/or generating modified acceptor peptide sequences for glycosylation by NGTs, and methods for preparing glycoproteins and recombinant glycoproteins in vitro and in vivo using the modified NGTs and/or acceptor peptide sequences. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/005826 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294970 | CHING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mammoth Biosciences, Inc. (Brisbane, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesus CHING (Saratoga, California); James Paul BROUGHTON (South San Francisco, California); Janice Sha CHEN (San Francisco, California); Sarah Jane SHAPIRO (Pacifica, California); Elizabeth Mae HAWKINS (Redwood City, California); Sonal JAIN (San Mateo, California); Lior KREINDLER (Foster City, California); Sophia HUBBELL (San Francisco, California) |
| ABSTRACT | Described herein are methods, devices, and compositions for immobilization of biomolecules in diagnostic assays onto a surface. The methods, devices, and compositions may utilize or comprise a plurality of different non-naturally occurring guide nucleic acids. Each of the different non-naturally occurring guide nucleic acids may be immobilized to a surface at a known location identified with the particular non-naturally occurring guide nucleic acid, Alternatively, or in combination, a plurality of programmable nucleases may be immobilized to the surface at each of the known locations. Optionally, the methods, devices, and compositions may utilize or comprise a plurality of reporters immobilized to the surface in proximity to each of the different non-naturally occurring guide nucleic acids and/or programmable nucleases at each of the known locations. |
| FILED | Tuesday, June 13, 2023 |
| APPL NO | 18/334327 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/44 (20130101) C12Q 1/6806 (20130101) C12Q 1/6823 (20130101) Original (OR) Class C12Q 1/6844 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6432 (20130101) G01N 2333/922 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295390 | Bailey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vertex Aerospace LLC (Hewitt, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Bailey (Avon, Indiana); James T. Erdmann (Indianapolis, Indiana); Stephen A. Streib (Greenfield, Indiana); Armando Guerrero (Columbus, Indiana); Roy P. Mcmahon (Indianapolis, Indiana); Jessica R. Deherdt (Indianapolis, Indiana) |
| ABSTRACT | A munitions rack includes a munitions rack structure that houses multiple compact ejectors. The structure includes a pair of internal longitudinal ribs, inboard of a pair of external longitudinal ribs. A spine of the munitions rack structure links all the ribs, and the munitions rack structure may be formed out of a single piece of material. The ribs define a pair of side recesses on the port and starboard sides of the bomb, which each may be further subdivided into a forward pocket and an aft pocket. Removable ejectors are located in the pockets. The ejectors may receive pressurized gas from pressurized gas source(s) located outside of the ejectors. The ejectors may each have multiple forward pistons and multiple aft pistons. The ejectors may include pitch control valving to control the relative amounts of pressurized gas sent to the forward piston(s) and aft piston(s). |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/345413 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/04 (20130101) B64D 7/08 (20130101) Weapon Sights; Aiming F41G 7/007 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 39/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295518 | Potyrailo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York) |
| ABSTRACT | The techniques described herein provide sensing systems and methods that provide configurable sensitivity and extended dynamic range of gas measurements. The systems and methods apply dielectric excitation at two or more excitation frequencies to a sensing material via sensing electrodes. A linearity of the electrical signal is changed by changing the operation parameters of the gas sensing element of the sensor. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116162 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/44 (20130101) G01N 27/221 (20130101) Original (OR) Class G01N 27/227 (20130101) G01N 2027/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295536 | Potyrailo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York); Janell Marie Crowder (Clifton Park, New York); Richard St. Pierre (Clifton Park, New York); Baokai Cheng (Niskayuna, New York) |
| ABSTRACT | A sensor device may include an electrochemical (EC) gas sensor, a metal-oxide semiconductor (MOS) gas sensor, and control circuitry. The control circuitry may provide EC excitation signals to the EC gas sensor, provide at least two MOS excitation signals to the MOS gas sensor, and detect at least two gases. The control circuitry may detect the gases based on receiving EC response signals from the at least one EC gas sensor based on providing the EC excitation signals, receiving MOS response signals from the MOS gas sensor based on providing the MOS excitation signals, determining a multivariate response pattern based on the EC response signals and the MOS response signals, and differentiating between the at least two gases in contact with the sensor device based on the multivariate response pattern. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116174 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0006 (20130101) G01N 33/0062 (20130101) G01N 33/0068 (20240501) G01N 33/0073 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295546 | Kerr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States (Air Force) (Wright-Patterson AFB, Ohio); Miami University (Oxford, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lei L. Kerr (Oxford, Ohio); Saber M. Hussain (Beavercreek, Ohio); Andrew Yerich (Oxford, Ohio) |
| ABSTRACT | The anatomical model of a nasal cavity, such as a human nasal cavity, for in-vitro inhalation studies such as toxicological screening, intranasal drug delivery studies, and neurophysiological studies. The model includes a model body including separable upper and lower model portions together defining the nasal cavity and including fluidic channels therein that define an olfactory region of the upper model portion, and a nasal passage defined in the lower model portion. A biocompatible porous membrane is positioned between the upper and lower model portions, and the biocompatible membrane is configured for culturing olfactory epithelium cells thereon. An artificial mucous layer coats a surface of the nasal cavity and is configured to collect particles passing through the nasal cavity. |
| FILED | Tuesday, May 07, 2024 |
| APPL NO | 18/657138 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3835 (20130101) B29C 33/3842 (20130101) B29C 39/02 (20130101) B29C 64/386 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/40 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) C12N 2513/00 (20130101) C12N 2533/00 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) Original (OR) Class Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/30 (20130101) G09B 23/34 (20130101) G09B 23/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295733 | Preece et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley L. Preece (Lorton, Virginia); John M. Hall (Stafford, Virginia) |
| ABSTRACT | For see-through AR displays, the current state of art uses geometric correction to lower the display location error, however this is far from an ideal solution and requires knowing range or pose of the devices. A dual-function optic for near-to-eye display & camera is disclosed, wherein a sensor camera imaging optics pipeline with a virtual projection point at an eye's retina reduces parallax errors to zero. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/116563 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/30 (20130101) G02B 27/0101 (20130101) Original (OR) Class G02B 27/0179 (20130101) G02B 27/1013 (20130101) G02B 2027/014 (20130101) G02B 2027/0138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295775 | Tabirian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beam Engineering for Advanced Measurements Co. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nelson V. Tabirian (Winter Park, Florida); David E. Roberts (Apopka, Florida) |
| ABSTRACT | Diffractive optical structures, lenses, waveplates, devices, systems, and methods, which have the same effect on light regardless of the polarization state of the light, utilizing systems of polarization discriminator diffractive waveplate optics and differential polarization converters with special arrangements that do not require introducing spatial separation between the layers. |
| FILED | Friday, May 10, 2024 |
| APPL NO | 18/660828 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/133526 (20130101) G02F 1/133638 (20210101) Original (OR) Class G02F 2201/305 (20130101) G02F 2203/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296334 | Dang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (ARMONK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuan-Hong Dang (Chappaqua, New York); Dinesh C. Verma (New Castle, New York); Seraphin Bernard Calo (Cortlandt Manor, New York); Petros ZERFOS (New York, New York) |
| ABSTRACT | A method, computer system, and a computer program product for training a machine learning model are provided. A first set of labelled training data from a source domain is obtained. A second set of labelled training data from a target domain is obtained. A number of labelled samples of the first set is greater than a number of labelled samples of the second set. The first machine learning model is trained with the first set and the second set and with a discriminator so that the discriminator is unable to distinguish whether a sample is from the first set or from the second set. The first machine learning model is trained with triplet loss regularization using the first set and the second set. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/177839 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/094 (20230101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296365 | Temme et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Kristan Temme (Ossining, New York); Ewout van den Berg (Bronxville, New York); Riddhi Swaroop Gupta (San Jose, California); Abhinav Kandala (Yorktown Heights, New York) |
| ABSTRACT | Systems and techniques that facilitate noise learning in dynamic quantum circuits are provided. In various embodiments, a system can learn noise associated with a mid-circuit non-unitary operation of a dynamic quantum circuit, by modifying the mid-circuit non-unitary operation with a probabilistic Pauli-Z gate and twirled Pauli operators. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178240 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296368 | SEIF TABRIZI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Alireza SEIF TABRIZI (Adelphi, Maryland); Mohammad HAFEZI (Washington, District of Columbia); Yi-Kai LIU (Gaithersburg, Maryland) |
| ABSTRACT | A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654208 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296914 | Ekins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Collaborations Pharmaceuticals, Inc. (Fuquay Varina, North Carolina) |
| ASSIGNEE(S) | Collaborations Pharmaceuticals, Inc. (Fuquay Varina, North Carolina) |
| INVENTOR(S) | Sean Ekins (Fuquay Varina, North Carolina); Kushal Batra (Raleigh, North Carolina); Maggie Anne Hupcey (Fuquay Varina, North Carolina); Fabio Lee Urbina (Chapel Hill, North Carolina) |
| ABSTRACT | Methods, systems, and computer readable media for predicting a spectrum, e.g., a UV-Vis spectrum, of a target molecule are disclosed. According to one aspect, a descriptor, such as a SMILES sequence or extended connectivity fingerprint, of the target molecule can be provided or generated and analyzed via a trained machine learning model, such as a trained long-short term memory (LSTM) model, to predict the spectrum of the target molecule. As determined via a variety of statistical measures, the methods, systems and computer readable media can predict the complete UV spectrum of a target molecule with high accuracy over the entire spectrum. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 18/272982 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201) G16C 20/30 (20190201) Original (OR) Class G16C 20/70 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297472 | Soljacic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Tecnology (Cambridge, Massachusetts); Technion Research and Development Foundation Limited (Haifa, Israel) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marin Soljacic (Belmont, Massachusetts); Ido Kaminer (Haifa, Israel); Nicholas Rivera (Somerville, Massachusetts); Jamison Sloan (Somerville, Massachusetts); Yannick Salamin (Arlington, Massachusetts) |
| ABSTRACT | A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described. |
| FILED | Tuesday, April 12, 2022 |
| APPL NO | 18/283400 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 1/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297563 | Toliyat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas); Board of Regents, The University of Texas System (Austin, Texas); US Army Research Laboratory (Adelphi, Maryland); US Hybrid Corporation (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamid A. Toliyat (College Station, Texas); Bryton Praslicka (College Station, Texas); Daniel Zamarron (Bryan State, Texas); Matthew C. Gardner (Dallas, Texas); Matthew C. Johnson (College Station, Texas); Abas Goodarzi (Rolling Hills, California); Enzo Bauk (Lakewood, California); Alex Nguyen (Fullerton, California); Shima Hasanpour (College Station, Texas); Godwin Yuan Duan (Plano, Texas); Salek Khan Richardson (Richarson, Texas) |
| ABSTRACT | Aspects of the disclosure relate to a cycloidal magnetic gear. The cycloidal magnetic gear includes an outer rotor. A plurality of magnetic pole pairs is disposed on an inner circumference of the outer rotor. A first, second, and third inner rotor is disposed within the outer rotor. The first, second, and third inner rotors includes a magnetic pole pairs disposed on an outer circumference thereof. The first inner rotor and the third inner rotor have a thickness of approximately half the thickness of the second inner rotor. The first inner rotor, the second inner rotor, and the third inner rotor balance moments acting on a drive shaft. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/273941 |
| CURRENT CPC | Dynamo-electric Machines H02K 16/00 (20130101) H02K 51/00 (20130101) Original (OR) Class H02K 2213/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297599 | Perkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edmon Perkins (Raleigh, North Carolina); XiaoFu Li (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to resonance tracking broadband energy harvesting. In one example, a resonance tracking energy harvester includes a pendulum adaptive frequency oscillator including an adjustable pendulum rod and control circuitry that can adjust a length of the adjustable pendulum rod in response to a sensed forcing frequency. In another example, a method of resonance tracking energy harvesting, includes sensing a forcing frequency applied to a pendulum adaptive frequency oscillator comprising an adjustable pendulum rod; and adjusting a length of the adjustable pendulum rod in response to the sensed forcing frequency. Oscillation and/or vibration of the pendulum adaptive frequency oscillator can be converted. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594514 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 3/12 (20130101) Electric Machines Not Otherwise Provided for H02N 2/188 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297630 | Chandrahalim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Hengky Chandrahalim (Beavercreek, Ohio); David Lynes (Wright-Patterson AFB, Ohio) |
| ABSTRACT | A method of enhancing an electromechanical coupling coefficient of a microelectromechanical (“MEMS”) device. The method includes applying, to a fully fabricated MEMS device, heavy particle ion radiation to the MEMS device at a fluence of at least 1×1014 cm−2. According to other embodiments of the present invention are directed to a bandpass filter comprising a plurality of MEMS devices fabricated in accordance with the methods provided. The MEMS of the plurality are electronically or mechanically coupled. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584112 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/0072 (20130101) Original (OR) Class H03H 9/48 (20130101) H03H 2003/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297892 | Fisher, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Edward Fisher, III (Zebulon, North Carolina); Steven J. Lorenc (Wake Forest, North Carolina) |
| ABSTRACT | A method, system, and computer-readable media for modeling cyberspace operations and the effects thereof. Network and connectivity data for an operational environment model may be retrieved from a network scan. Likelihood data that a network element takes a plurality of possible configurations may be mapped. Determination of a probability of effect of a capability acting on the network element may be based on the likelihood data and uncertainties associated with the capability. Multiple attacks within the operational environment model may be modeled to determine an attack path therethrough. Functional modeling techniques to model functional impacts of attacks on an operational environment model are also disclosed. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/178264 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240298521 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judy Z. Wu (Lawrence, Kansas); Maogang Gong (Lawrence, Kansas); Bo Liu (Lawrence, Kansas); Andrew Shultz (Lawrence, Kansas) |
| ABSTRACT | Provided are methods of fabricating photodetectors based on heterostructures comprising graphene and mercury chalcogenide, e.g., HgTe, quantum dots. Embodiments of the methods are able to provide photodetectors that can detect MWIR light, e.g., greater than 3 mm at room temperature with responsivities R* of at least 104 A/W and detectivities D* of at least 1011 Jones. Thus, the present photodetectors outperform existing MWIR photodetectors without the need for cooling. The photodetectors themselves are also encompassed. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589836 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/77 (20130101) C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/32 (20130101) C01P 2004/64 (20130101) C01P 2006/40 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) Organic electric solid-state devices H10K 85/381 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20240292833 | Kaeppler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn Kaeppler (Middleton, Wisconsin); Heidi Kaeppler (Middleton, Wisconsin); Michael William Petersen (Merrimac, Wisconsin); Brian Joseph Martinell (Mount Horeb, Wisconsin); Frank McFarland (Middleton, Wisconsin) |
| ABSTRACT | The present invention provides pollen compositions, methods and kits for making said compositions, and methods of using said compositions to fertilize a plant. The pollen within these compositions has increased longevity and can be used to fertilize plants for an extended period of time as compared to pollen prepared using conventional methods. Also provided are methods of collecting pollen from a maize plant by maturing individual tassel branches off of the plant and vessels for collecting the pollen from these individual branches. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650704 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) A01H 6/4684 (20180501) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293362 | ELLSWORTH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Edmund L. ELLSWORTH (Vicksburg, Michigan); Kin Sing Stephen LEE (East Lansing, Michigan) |
| ABSTRACT | Compounds and methods to treat or prevent CNS diseases, such as Alzheimer's disease and brain injury inflammation, are disclosed herein. The compounds are soluble epoxide hydrolase (sEH) inhibitors and have improved physical properties, blood-brain-barrier (BBB) penetration and long drug-target residence time. Pharmaceutical compositions and kits comprising the compounds are also disclosed herein. |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/634344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) Original (OR) Class A61K 31/46 (20130101) A61K 31/397 (20130101) A61K 31/403 (20130101) A61K 31/407 (20130101) A61K 31/438 (20130101) A61K 31/439 (20130101) A61K 31/4439 (20130101) A61K 31/4468 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/09 (20130101) C07D 207/14 (20130101) C07D 209/52 (20130101) C07D 211/58 (20130101) C07D 221/24 (20130101) C07D 401/12 (20130101) C07D 451/04 (20130101) C07D 471/10 (20130101) C07D 487/04 (20130101) C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293806 | Zhao |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhao (Ames, Iowa) |
| ABSTRACT | The disclosure relates to molecularly-imprinted cross-linked micelles that can selectively hydrolyze carbohydrates. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/636070 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/067 (20130101) Original (OR) Class B01J 35/23 (20240101) B01J 37/04 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294442 | DETSI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric DETSI (Wallingford, Pennsylvania); Timothy LEE (Pine Brook, New Jersey); John S. CORSI (Somerville, Massachusetts) |
| ABSTRACT | Hydrolysis of water-reactive nanoporous nonprecious metals to produce hydrogen fuel on-demand for non-stationary applications is a promising method to overcome infrastructural limitations associated with current hydrogen storage and delivery systems. However, the pyrophoricity of highly reactive nanoporous nonprecious metals presents a safety and stability issue. Herein we demonstrate a method to stabilize pyrophoric nanoporous nonprecious metals by using a composite pellet structure consisting of a nanoporous nonprecious metal and a highly hygroscopic material that (i) can trap and absorb high quantities of water vapor to prevent heat buildup and subsequent pyrophoric ignition from exothermic oxidation from oxygen, and (ii) can also undergo hydrolysis to produce hydrogen, thus, making it possible to suppress the pyrophoricity without sacrificing the overall hydrogen generation yield of the composite. Lithium hydroxide and lithium borohydride were investigated as two candidate hygroscopic materials for their ability to absorb water vapor. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 18/292522 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/065 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 33/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294450 | Dinca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mircea Dinca (Belmont, Massachusetts); Constanze Nicole Neumann (Somerville, Massachusetts) |
| ABSTRACT | Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/423216 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/46 (20130101) B01J 31/1691 (20130101) B01J 2231/46 (20130101) B01J 2531/0208 (20130101) B01J 2531/821 (20130101) B01J 2531/845 (20130101) B01J 2531/847 (20130101) Acyclic or Carbocyclic Compounds C07C 29/16 (20130101) C07C 29/44 (20130101) Original (OR) Class C07C 31/12 (20130101) C07C 31/125 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/04 (20130101) C07F 15/06 (20130101) C07F 15/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294570 | LIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts); HEBECELL CORP. (Natick, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shuang LIU (Waltham, Massachusetts); Shijiang LU (Shrewsbury, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | An isolated peptide having the structure: where —NH-Q-C(O)— is an α-helical amino acid sequence that includes at least 4 and up to 30 amino acid residues, Z1 is a moiety including an aromatic group or a fluorophore, Z2 includes a phosphorylated amino acid residue, or the dephosphorylated amino acid residue. These peptides, in dephosphorylated form, are capable of self-assembly in the form of a nanoribbon, nanofiber, or a combination thereof. Such peptides are capable of causing cell death of cells that overexpress alkaline phosphatases, which includes cancer cells and induced pluripotent stem cells (iPSCs), and therefore the peptides of the invention can be used ex vivo to selectively cause cell death of cancer cells or iPSCs, or in vivo to cause cancer cell death. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573504 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 38/00 (20130101) Peptides C07K 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294595 | Polt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robin L. Polt (Tucson, Arizona); Torsten A E Falk (Tucson, Arizona); Michael L. Heien (Tucson, Arizona); John Streicher (Tucson, Arizona) |
| ABSTRACT | Glycopeptides comprising a peptide that is covalently linked to a saccharide. The peptide portion of the glycopeptides of the invention has from about 20 to about 40 amino acid residues and at least 75% sequence identity to SEQ ID NO:5. The saccharide moiety portion of the glycopeptides of the present invention comprises from 1 to about 8 carbohydrates. The present invention also relates to using the glycopeptides of the invention in treating various neurodegenerative diseases. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/530028 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/57563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294611 | MAYNARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eduardo PADLAN (Kensington, Maryland); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer MAYNARD (Austin, Texas); Yimin HUANG (Austin, Texas); Annalee NGUYEN (Austin, Texas); Ching-Lin HSIEH (Austin, Texas); Jason MCLELLAN (Austin, Texas); Rui P. SILVA (Austin, Texas); Edurado PADLAN (Kensington, Maryland) |
| ABSTRACT | Provided herein are antibodies and antibody fragments that bind to the S2 domains of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins. Methods of using these antibodies in in vitro methods are provided. Methods of using these antibodies in vivo to treat or prevent SARS-CoV-2 infections are also provided. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 18/260891 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 16/1002 (20230801) C07K 16/1003 (20230801) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/20022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2469/10 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294675 | Niu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Jia Niu (Lexington, Massachusetts); Wenyu Huang (Ames, Iowa); Zefeng Zhou (Waltham, Massachusetts) |
| ABSTRACT | This patent document provides a caged catalyst comprising a catalyst encapsulated in a cage compound of Formula I represented [ZrIV6O4(OI)4(linker)6]). The catalysts demonstrated excellent activities and size selectivity in a model RCM reaction, suggesting successful encapsulation into MOFs. ROMP of cyclopentene mediated by G3@UiO-67 achieved significantly higher molecular weight and lower dispersity than the counterpart mediated by the free catalyst. The ultra-high molecular weight polymers generated by the encapsulated catalysts demonstrated significantly improved mechanical and adhesive properties compared to the low molecular weight counterparts and commercial polymers. The simplicity and generality make this method readily applicable to the ROMP of a wide range of low-strain cyclic olefins. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589967 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/80 (20130101) Original (OR) Class C08F 112/06 (20130101) C08F 234/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294709 | HERNANDEZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATON, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nacu HERNANDEZ (Ames, Iowa); Mengguo YAN (San Jose, California); Eric William COCHRAN (Ames, Iowa); John Edward MATTHIESEN (Hillsboro, Oregon); Jean-Philippe TESSONNIER (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623237 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294718 | PAULSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SYRACUSE UNIVERSITY (Syracuse, New York); ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph PAULSEN (Syracuse, New York); Vincent DEMERY (Lyon, France) |
| ABSTRACT | Thin elastic films that can spontaneously attach to liquid interfaces, thereby offering a platform for tailoring their physical, chemical, and optical properties. Curved shells can be used to manipulate interfaces in qualitatively different ways. For example, an ultrathin shell with vanishing bending rigidity can impose its own rest shape on a liquid surface, in a process where the pressure across the interface inflates the shell into its original shape. The approach is amenable to optical applications as the shell is transparent, free of wrinkles, and may be manufactured over a range of curvatures. |
| FILED | Wednesday, June 22, 2022 |
| APPL NO | 18/573482 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Original (OR) Class C08J 2325/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294776 | Akintola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Akintola (Tallahassee, Florida); Joseph Schlenoff (Tallahassee, Florida) |
| ABSTRACT | Described herein are articles coated with one or more polyelectrolyte complexes. The polyelectrolyte complexes have a high glass transition temperature when the coating is contacted with an aqueous medium. In one aspect, the coating has a glass transition temperature of at least 45° C. when in contact with an aqueous medium, which makes the coatings described herein as “glassy.” The coating compositions described herein are effective in reducing adhesion of organisms on the surface of the coated article, which makes the coatings an effective antifouling coating. |
| FILED | Thursday, February 15, 2024 |
| APPL NO | 18/442166 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 212/30 (20200201) C08F 226/02 (20130101) C08F 226/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/124 (20130101) C08G 65/2636 (20130101) C08G 65/4012 (20130101) C08G 75/14 (20130101) C08G 75/20 (20130101) C08G 75/029 (20130101) C08G 2650/40 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) Original (OR) Class C09D 7/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294957 | Pluskal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| INVENTOR(S) | Tomás Pluskal (Boston, Massachusetts); Jing-Ke Weng (Belmont, Massachusetts) |
| ABSTRACT | Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers. |
| FILED | Wednesday, July 12, 2023 |
| APPL NO | 18/350985 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) C12P 17/06 (20130101) Original (OR) Class Enzymes C12Y 301/27005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294962 | ROMESBERG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd E. ROMESBERG (La Jolla, California); Vivian T. DIEN (San Diego, California); Aaron W. FELDMAN (San Diego, California); Rebekah J. KARADEEMA (San Diego, California); Lingjun LI (Xinxiang, China PRC); Michael P. LEDBETTER (Jamaica Plain, Massachusetts); Anne Xiaozhou ZHOU (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532609 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/24 (20130101) C07H 21/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294963 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael C. Jewett (Evanston, Illinois); Weston K. Kightlinger (Evanston, Illinois); Milan Mrksich (Evanston, Illinois); Liang Lin (Evanston, Illinois) |
| ABSTRACT | Disclosed are compositions, systems, and methods for synthesizing glycoproteins or recombinant glycoprotein protein in vitro and in vivo. In particular, the present invention relates to modified N-glycosyltransferases (NGTs), method for generating modified NGTs, methods for identifying and/or generating modified acceptor peptide sequences for glycosylation by NGTs, and methods for preparing glycoproteins and recombinant glycoproteins in vitro and in vivo using the modified NGTs and/or acceptor peptide sequences. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 18/005826 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295038 | Qi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Long Qi (Ames, Iowa); Wenyu Huang (Ames, Iowa); Sen Zhang (Crozet, Virginia); Zhouyang Yin (Fremont, California); Lun An (Ames, Iowa); Kanika Lalit (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Long Qi (Ames, Iowa); Wenyu Huang (Ames, Iowa); Sen Zhang (Crozet, Virginia); Zhouyang Yin (Fremont, California); Lun An (Ames, Iowa); Kanika Lalit (Ames, Iowa) |
| ABSTRACT | A metal-impregnated carbon material includes a mesoporous carbon matrix including a metal M. The metal M is bonded directly to the carbon matrix, M is bonded directly to an atom A that is bonded directly to the carbon matrix, or a combination thereof. At each occurrence, A is independently chosen from N, O, P, S, and B. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/593685 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295252 | Bonessio |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | METAseismic, Inc. (Berkeley, California) |
| ASSIGNEE(S) | METAseismic, Inc. (Berkeley, California) |
| INVENTOR(S) | Noemi Bonessio (Berkeley, California) |
| ABSTRACT | A tri-adaptive apparatus is disclosed and configured for functioning as a dynamic force isolation and dampening metamaterial that reduces the transmission of dynamic forces between a dynamic force source and an object. In at least one embodiment, the apparatus provides at least one cell unit that provides a pair of opposing first and second cell plates, between which is positioned at least one spring, restrainer and dashpot. An outer surface of the first cell plate is positioned in contact with the dynamic force source. An outer surface of the second cell plate is positioned in contact with the object. The at least one spring, restrainer and dashpot are configured for transferring dynamic force energy mutually between one another while deforming mechanically in response to the dynamic forces transmitted by the dynamic force source. |
| FILED | Thursday, April 25, 2024 |
| APPL NO | 18/646667 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 13/04 (20130101) Original (OR) Class F16F 2228/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295459 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore County (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weidong ZHU (Ellicott City, Maryland); Linfeng LYU (Halethorpe, Maryland) |
| ABSTRACT | A one-dimensional (1D) and two-dimensional (2D) scan scheme for a tracking continuously scanning laser Doppler vibrometer (CSLDV) system to scan the whole surface of a rotating structure excited by a random force. A tracking CSLDV system tracks a rotating structure and sweep its laser spot on its surface. The measured response of the structure using the scan scheme of the tracking CSLDV system is considered as the response of the whole surface of the structure subject to random excitation. The measured response can be processed by operational modal analysis (OMA) methods (e.g., an improved lifting method, an improved demodulation method, an improved 2D demodulation method). Damped natural frequencies of the rotating structure are estimated from the fast Fourier transform of the measured response. Undamped full-field mode shapes are estimated by multiplying the measured response using sinusoids whose frequencies are estimated damped natural frequencies. |
| FILED | Friday, February 09, 2024 |
| APPL NO | 18/437773 |
| CURRENT CPC | Wind Motors F03D 17/00 (20160501) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295544 | McDevitt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Glads (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd C. McDevitt (San Francisco, California); Bruce Conklin (San Francisco, California); Melanie Ott (Mill Valley, California); Juan Perez-Bermejo (San Francisco, California); Michael Sungwon Kang (San Francisco, California); Sarah Rockwood (Kensington, California); Camille Simoneau (San Francisco, California); Gokul Ramadoss (Oakland, California); David Joy (Oakland, California) |
| ABSTRACT | Provided herein are methods and compositions useful for identifying compounds that can inhibit SARS-CoV-2 infection or the effects thereof, especially in cardiomyocytes (CMs), which are highly infectible by SARS-CoV-2 corona viruses. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 18/022428 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5035 (20130101) G01N 33/5061 (20130101) Original (OR) Class G01N 33/6887 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295792 | Guha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Saikat Guha (Tucson, Arizona); Prajit Dhara (Tucson, Arizona) |
| ABSTRACT | Entangled optical outputs are generated using one or more heralded entanglement sources, each comprising: first and second free-running entanglement sources, each providing a first (third) optical output comprising a quantum superposition of a pair of orthogonal optical modes, and a second (fourth) optical output comprising a quantum superposition of a pair of orthogonal optical modes; an optical module configured to perform an interferometric measurement based on optical interference between at least a portion of the first optical output and at least a portion of the third optical output, and to generate one or more detection signals based on the interferometric measurement in a series of time slots; and a trigger module configured to generate a trigger signal based on the one or more detection signals to indicate one or more time slots in which the second optical output and the fourth optical output are entangled with each other. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 18/291617 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3517 (20130101) G02F 1/3526 (20130101) Original (OR) Class G02F 1/3534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296330 | Iandola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forrest Nelson Iandola (San Jose, California); Harsimran Singh Sidhu (Fremont, California); Yiqi Hou (Berkeley, California) |
| ABSTRACT | A neural network architecture is used that reduces the processing load of implementing the neural network. This network architecture may thus be used for reduced-bit processing devices. The architecture may limit the number of bits used for processing and reduce processing to prevent data overflow at individual calculations of the neural network. To implement this architecture, the number of bits used to represent inputs at levels of the network and the related filter masks may also be modified to ensure the number of bits of the output does not overflow the resulting capacity of the reduced-bit processor. To additionally reduce the load for such a network, the network may implement a “starconv” structure that permits the incorporation of nearby nodes in a layer to balance processing requirements and permit the network to learn from context of other nodes. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/664035 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/575 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296577 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Song Zhang (West Lafayette, Indiana); Liming Chen (West Lafayette, Indiana) |
| ABSTRACT | Systems and methods of large depth-of-field microscopic structured-light 3D imaging include and/or implement capturing a plurality of images of a scene using a plurality of focus settings, each of the plurality of images corresponding to one of the plurality of focus settings, the plurality of images corresponding to a focal stack; processing the plurality of images; merging the plurality of images into an all-in-focus phase map; and reconstructing a 3D shape of the scene based on the all-in-focus phase map. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/596251 |
| CURRENT CPC | Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 17/54 (20130101) Image Data Processing or Generation, in General G06T 7/571 (20170101) Original (OR) Class G06T 17/00 (20130101) G06T 2207/10016 (20130101) Pictorial Communication, e.g Television H04N 23/12 (20230101) H04N 23/743 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296582 | Ramani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Hyung-gun Chi (West Lafayette, Indiana); Seunggeun Chi (West Lafayette, Indiana) |
| ABSTRACT | An approach for pose estimation is disclosed that can mitigate the effect of occlusions. A POse Relation Transformer (PORT) module is configured to reconstruct occluded joints given the visible joints utilizing joint correlations by capturing the implicit joint occlusions. The PORT module captures the global context of the pose using self-attention and a local context by aggregating adjacent joint features. To train the PORT module to learn joint correlations, joints are randomly masked and the PORT module learns to reconstruct the masked joints, referred to as Masked Joint Modeling (MJM). Notably, the PORT module is a model-agnostic plug-in for pose refinement under occlusion that can be plugged into any existing or future keypoint detector with substantially low computational costs. |
| FILED | Thursday, February 22, 2024 |
| APPL NO | 18/584191 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/73 (20170101) Original (OR) Class G06T 2207/20044 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/44 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296906 | Momeni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Babak Momeni (Cambridge, Massachusetts); Marco Zaccaria (Malden, Massachusetts); Natalie Sandlin (Watertown, Massachusetts) |
| ABSTRACT | A partner-assisted artificial selection (PAAS) approach, in which an assisting population acts as an intermediate to create feedback from the function of interest to the fitness of the producer. The selection for improved growth in this approach successfully leads to improved degradation performance, even in the presence of other sources of stochasticity. Successful implementation of PAAS evolves improved functions of interest such as detoxification of harmful compounds. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311385 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/40 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296998 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jong Hyun Choi (West Lafayette, Indiana); Jaehoon Ji (Princeton, New Jersey) |
| ABSTRACT | Composite electrodes, supercapacitors equipped therewith, ternary materials for composite electrodes, and related methods. Such a composite electrode has a composite CNT-ZIF structure formed of a conductive network of carbon nanotubes (CNT) and a zeolitic imidazole framework (ZIF) coating covering the conductive network. A layer of molybdenum disulfide (MoS2) structures having flower-like morphologies is disposed on the composite CNT-ZIF structure. The MoS2 structures have pores that provide diffusion paths for ions to and/or from the ZIF coating and/or the conductive network of CNT. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594193 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297324 | WEI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| INVENTOR(S) | Shuya WEI (Albuquerque, New Mexico); Cameron CARUGATI (Albuquerque, New Mexico); Christopher FETROW (Albuquerque, New Mexico) |
| ABSTRACT | Rechargeable electrochemical devices and methods for the same are disclosed. The electrochemical devices may include an anode, a cathode, and an electrolyte disposed between the anode and the cathode. The electrolyte may include a deep eutectic mixture and an electrolyte additive. The deep eutectic mixture may include an ion coordinated complex prepared from a combination of aluminum chloride (AlCl3) and an amide or a combination of AlCl3 and an organic salt. |
| FILED | Monday, May 06, 2024 |
| APPL NO | 18/655565 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297357 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng CHEN (San Diego, California); Panpan XU (San Diego, California) |
| ABSTRACT | A method for regeneration of spent cathode material of lithium-ion batteries involves lithiating the cathode material in a relithiation solution including a reducing agent at a temperature in the range of 60° C. to 180° C. for a sufficient time to heal composition defects in the cathode material. The lithiated material is then sintered to completely recover the properties. The relithiation solution may be a Li-ion source combined with nature-based organic reducing agent such as citric acid, ascorbic acid, tartaric acid, or similar. |
| FILED | Friday, April 12, 2024 |
| APPL NO | 18/634704 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 7/006 (20130101) C22B 26/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/049 (20130101) H01M 4/0471 (20130101) H01M 4/5825 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297611 | Shtein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max Shtein (Ann Arbor, Michigan); Erin Evke (Ann Arbor, Michigan); Michael Arwashan (Ann Arbor, Michigan); Chao Huang (Ann Arbor, Michigan) |
| ABSTRACT | A device includes a support structure having a plurality of concentric cuts through the support structure that define a set of structure sections. The device also includes an insert assembly supported by the support structure at an inner structure section of the set of structure sections. The inner structure section is configured to tilt the insert assembly at a tilt angle in accordance with a displacement of a first outer structure section of the set of structure sections. |
| FILED | Friday, October 27, 2023 |
| APPL NO | 18/496521 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 50/20 (20180501) F24S 50/80 (20180501) F24S 2030/10 (20180501) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/32 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297718 | Leon-Salas |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Walter Daniel Leon-Salas (West Lafayette, Indiana) |
| ABSTRACT | A system may include a solar cell and a modulator connected to an output of the solar cell. The system may receive a signal. When the signal being in a first state corresponding to modulation, the modulator may modulate voltage output of the solar cell and cause the solar cell to perform optical transmission. When the signal is in a second state corresponding to energy harvesting, the modulator to cease modulation of the output of the solar cell. |
| FILED | Tuesday, March 05, 2024 |
| APPL NO | 18/596455 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0693 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/35 (20130101) H02J 2300/24 (20200101) Transmission H04B 10/541 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20240294415 | Gilmer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| INVENTOR(S) | Dustin Blake Gilmer (Knoxville, Tennessee); Alexander Kendall Stiles (Knoxville, Tennessee) |
| ABSTRACT | A method of additive manufacturing is described wherein powder material is spread in a layer, contacted with a binding polymer and cured with light. Also described is a system for preparing additive manufactured objects such as molds, tools and composites. |
| FILED | Monday, July 25, 2022 |
| APPL NO | 18/573797 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) B29C 64/209 (20170801) B29C 64/218 (20170801) B29C 64/245 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2033/00 (20130101) B29K 2105/0058 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Manufacture, Shaping, or Supplementary Processes C03B 19/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294429 | ODUKOMAIYA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adewale ODUKOMAIYA (Denver, Colorado); Anastasia Nicole ADAY (Boulder, Colorado); Nicole Renee MENDOZA (Longmont, Colorado); Kerry Christine RIPPY (Golden, Colorado); Michael E. HIMMEL (Littleton, Colorado); Xiaowen CHEN (Arvada, Colorado); Lin Jay SIMPSON (Lakewood, Colorado); Michael Brennan PECHA (Littleton, Colorado); Michael Brandon GRIFFIN (Denver, Colorado) |
| ABSTRACT | The utilization of the byproducts from the deacetylation of lignocellulosic biomass from the production of ethanol to create cement additives and/or alternatives to ordinary portland cement (OPC) is described. These byproducts may be used to create black liquor bioash (BLA), activated lignin carbon (ALC), and/or lignin aerogel admixtures. In some embodiments, the byproduct may be combined with at least one binder to form alkali-activated materials (AAMs). |
| FILED | Friday, February 23, 2024 |
| APPL NO | 18/585226 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 26/24 (20130101) Original (OR) Class C04B 28/04 (20130101) C04B 28/26 (20130101) C04B 2103/603 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 11/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20240294553 — SIZE-SELECTIVE ACYCLIC CHELATORS AND THEIR USE FOR THE RECOVERY OF RARE EARTH ELEMENTS
| US 20240294553 | Thiele et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikki Thiele (Oak Ridge, Tennessee); Bruce A. Moyer (Oak Ridge, Tennessee); Janel Dempsey (Oak Ridge, Tennessee) |
| ABSTRACT | A chelator having a composition including a compound having a chemical structure of formula (I) is provided, wherein X is a linking group selected from one of an ethyl, a propyl, a diethyl ether, a cyclohexyl, and a benzyl; each of R1 and R2 is a moiety including a terminal group selected from one of a carboxylic acid, a phosphinic acid, a phosphonic acid, a phenol, an amide, a carboxylic acid ester, a phosphinic acid ester, a phosphonic acid ester, and a phenol ether; and R3 and R4 are each selected from one of a hydroxy or an alkoxy group. A metal-ion complex including the chelator is also provided. Methods of separating a plurality of metals by size and recovering rare-earth elements by size are further provided. |
| FILED | Friday, February 16, 2024 |
| APPL NO | 18/443585 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/00 (20130101) Original (OR) Class Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/44 (20130101) C22B 7/008 (20130101) C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294685 | SU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Xiao SU (Champaign, Illinois); Haley VAPNIK (Tarzana, California); Johannes ELBERT (Urbana, Illinois) |
| ABSTRACT | Rare earth elements (REEs) play an essential role in our modern society, being critical resources for the growing electronic devices and renewable energy technologies. For the reversible capture and release of REEs, we designed and synthesized a redox-copolymer poly(ferrocenylpropyl methacrylamide-co-methacrylic acid) (P(FPMAm-co-MAA)) that combines an ion-exchange carboxylic acid group for REE adsorption, and an redox-active ferrocene moiety for electrochemical regeneration. By molecularly tuning the copolymer composition, efficient adsorption uptake could be achieved alongside electrochemically regenerated adsorbent reuse. The copolymer sorbent showed stoichiometric binding for yttrium (Y), cerium (Ce), neodymium (Nd), europium (Eu), gadolinium (Gd), and dysprosium (Dy) based on carboxylic acid active site. |
| FILED | Thursday, June 09, 2022 |
| APPL NO | 18/568609 |
| CURRENT CPC | Separation B01D 15/203 (20130101) B01D 15/362 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/42 (20130101) C02F 2001/425 (20130101) C02F 2101/20 (20130101) C02F 2303/16 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 230/04 (20130101) Original (OR) Class Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 143/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294709 | HERNANDEZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATON, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nacu HERNANDEZ (Ames, Iowa); Mengguo YAN (San Jose, California); Eric William COCHRAN (Ames, Iowa); John Edward MATTHIESEN (Hillsboro, Oregon); Jean-Philippe TESSONNIER (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623237 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295038 | Qi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Long Qi (Ames, Iowa); Wenyu Huang (Ames, Iowa); Sen Zhang (Crozet, Virginia); Zhouyang Yin (Fremont, California); Lun An (Ames, Iowa); Kanika Lalit (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Long Qi (Ames, Iowa); Wenyu Huang (Ames, Iowa); Sen Zhang (Crozet, Virginia); Zhouyang Yin (Fremont, California); Lun An (Ames, Iowa); Kanika Lalit (Ames, Iowa) |
| ABSTRACT | A metal-impregnated carbon material includes a mesoporous carbon matrix including a metal M. The metal M is bonded directly to the carbon matrix, M is bonded directly to an atom A that is bonded directly to the carbon matrix, or a combination thereof. At each occurrence, A is independently chosen from N, O, P, S, and B. |
| FILED | Friday, March 01, 2024 |
| APPL NO | 18/593685 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 11/075 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295088 | BUSCHECK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. BUSCHECK (Pleasanton, California); Jeffrey A. BUSCHECK (Davis, California) |
| ABSTRACT | The present disclosure relates to a system for storing and time-shifting at least one of electrical power, excess electrical power, or renewable electrical power, to create low-carbon heat for future use in assisting with a production of asphalt paving material. The system makes use of a first thermally insulated storage subsystem containing a quantity of an asphalt paving material manufacturing component, and a first furnace configured to heat the asphalt paving material manufacturing component using an available supplemental energy source. A second thermally insulated storage subsystem is used to store a quantity of asphalt binder, and a second furnace is used to heat the quantity of asphalt binder. An air blower is used to supply a quantity of air to the first furnace to assist in a heating during a heat-charge phase of operation of the system in which both the quantity of asphalt paving material manufacturing component and the quantity of asphalt binder are pre-heated. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116191 |
| CURRENT CPC | Construction Of, or Surfaces For, Roads, Sports Grounds, or the Like; Machines or Auxiliary Tools for Construction or Repair E01C 23/14 (20130101) Original (OR) Class Details or Accessories of Furnaces, Kilns, Ovens, or Retorts, in so Far as They Are of Kinds Occurring in More Than One Kind of Furnace F27D 1/0033 (20130101) F27D 2099/0083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295367 | BUSCHECK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. BUSCHECK (Pleasanton, California); Ravindra Shrikrishna UPADHYE (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a system for storing and time-shifting at least one of power from a power grid, excess electrical power, renewable power, or heat for future use in assisting with a production of an industrial product. The system may incorporate a reservoir subsystem containing a quantity of a thermal storage medium, and configured to be heated using at least one of a heat-generation system or a heat-transfer system. A heating subsystem may also be incorporated which is configured to heat the quantity of thermal storage medium during a charge phase of operation, and which includes at least one of a first furnace for heating the quantity of thermal storage medium during the charge phase of operation using at least one of excess electrical power or renewable power, or a second furnace for heating the thermal storage medium during the charge phase of operation using O2 and at least one other combustible component, to form one of a carbon-neutral or carbon-negative heat. A discharge subsystem transfers a first thermal product carrying at least one of carbon-neutral or carbon-negative heat created from at least one of the first or second furnaces, in the form of a heated gas, which is used to create a second thermal product in a subsequent heat-intensive industrial operation. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116184 |
| CURRENT CPC | Separation B01D 3/143 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 12/00 (20130101) B01J 19/0013 (20130101) B01J 2219/00103 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 7/00 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0056 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296252 | Bhunia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Swarup Bhunia (Gainesville, Florida); Jonathan William Cruz (Gainesville, Florida); Junjun Huan (Gainesville, Florida); Soumyajit Mandal (Upton, New York) |
| ABSTRACT | Various embodiments of the present disclosure provide electromagnetic based secure contact-less integrity verification for an integrated circuit. In one example, an embodiment provides for mapping a signal to a pseudo-random number generator (PRNG) seed value, generating a PRNG output digital signal based on the PRNG seed value, encrypting the PRNG output digital signal based on a cipher function and a key, and generating an electromagnetic signal associated with the PRNG output digital signal to facilitate non-contact sensing of the electromagnetic signal by a probing system. |
| FILED | Wednesday, February 28, 2024 |
| APPL NO | 18/589578 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/584 (20130101) G06F 21/72 (20130101) Original (OR) Class G06F 21/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296261 | Gumussoy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Siemens Corporation (Washington, District of Columbia) |
| ASSIGNEE(S) | Siemens Corporation (Washington, District of Columbia) |
| INVENTOR(S) | Suat Gumussoy (Princeton, New Jersey); Xiaofan Wu (North Brunswick, New Jersey); Ulrich Muenz (Princeton, New Jersey) |
| ABSTRACT | A computer-implemented method for online calibration of power system model against a power system includes iteratively approximating the power system model, at sequential optimization steps, around a moving design point defined by parameter values of a set of calibration parameters of the power system model. At each optimization step, an approximated system model is used to transform a dynamic input signal into a model output signal, which is compared with measurement signals obtained from measurement devices installed in the power system that define an actual power system output signal generated in response to the dynamic input signal. Parameter values of the calibration parameters adjusted in a direction to minimize an error between the model output signal and the actual power system output signal. The power system model is calibrated against the power system based on resulting optimal values of the calibration parameters. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 18/550469 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/38 (20130101) H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296967 | TSILIFIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GE-Hitachi Nuclear Energy Americas LLC (Wilmington, North Carolina) |
| ASSIGNEE(S) | GE-Hitachi Nuclear Energy Americas LLC (Wilmington, North Carolina) |
| INVENTOR(S) | Panagiotis TSILIFIS (Troy, New York); Ahmad Waleed Ahmad Foaad AMER (Latham, New York); KMK Genghis KHAN (Niskayuna, New York) |
| ABSTRACT | A method of identifying at least one critical location on a physical structure includes receiving operational information related to an operation of the physical structure, the operational information including different time instances of the operation of the physical structure and the operation of the physical structure at different operational levels; predicting damage to the physical structure based on the operational information, predicted operation of the physical structure with at least one of the different operational levels, and at least one model of the physical structure such that initiation of the damage at a plurality of locations of the physical structure is predicted independent of a proximity of the sensors to each of the plurality of locations; and identifying the at least one critical location on the physical structure based on the predicted damage. |
| FILED | Thursday, December 28, 2023 |
| APPL NO | 18/399016 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0033 (20130101) Nuclear Reactors G21C 17/112 (20130101) Nuclear Power Plant G21D 3/001 (20130101) G21D 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297017 | Barrows et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SHINE Technologies, LLC (Janesville, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Preston Barrows (Madison, Wisconsin); Tye Gribb (Fitchburg, Wisconsin) |
| ABSTRACT | A beam accelerator system comprises an ion accelerator that generates an ion beam, a low-pressure chamber, an anode, a plasma window, and a cathode housing. The plasma window comprises a plurality of cooling plates. Each cooling plate comprises a central wall surrounding the aperture, a cooling chamber surrounding the central wall, one or more impingement channels, and one or more return channels. Each of the impingement channels and return channels enter the cooling plate from an outer edge of the cooling plate and extend toward the aperture to the cooling chamber. Each of the one or more impingement channels are configured to provide an entrance pathway for cooling fluid to enter the cooling chamber and each of the one or more return channels are configured to provide an exit pathway for heated fluid to exit the cooling chamber. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116036 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/3171 (20130101) Original (OR) Class H01J 37/3244 (20130101) H01J 37/3447 (20130101) H01J 2237/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297199 | Leonard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Francois Leonard (Brentwood, California); Maurice Garcia-Sciveres (Oakland, California); Mi-Young Im (Berkeley, California); Yuan Mei (El Sobrante, California); Andrew Nonaka (Concord, California); Aikaterini Papadopoulou (Oakland, California); Archana Raja (Kensington, California); Grigory Tikhomirov (Berkeley, California) |
| ABSTRACT | A pixelated electronic sensor is disclosed for imaging from infra-red to ultraviolet wavelengths, composed of a CMOS integrated circuit plus layers of nano-materials monolithically integrated via low temperature post-processing. Co-design, simulation, and integration methods for the device are described. Each pixel has color-resolved single photon sensitivity without dark counts and without inefficiency. The device operates at temperatures above 70° Kelvin. Current state of the art imagers that can color-resolve single photons are of bolometric or filter type. Bolometric devices must operate at temperature below 1° Kelvin and are limited to few pixels. Devices that use filters are inefficient as all the photons rejected by a filter are wasted. Single photon imagers that operate at non-cryogenic temperature (like Silicon Photomultipliers) have large dark counts typically measured in MHz/cm2. Imaging applications include astronomical telescopes, exoplanet imaging, distant galaxy imaging, microscopic imaging, medical devices, and hyperspectral imaging. |
| FILED | Friday, March 22, 2024 |
| APPL NO | 18/613895 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14652 (20130101) Original (OR) Class H01L 27/14683 (20130101) H01L 31/18 (20130101) H01L 31/02005 (20130101) H01L 31/035218 (20130101) H01L 31/035227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297270 | Armitage |
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| FUNDED BY |
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| APPLICANT(S) | Lumileds LLC (San Jose, California) |
| ASSIGNEE(S) | Lumileds LLC (San Jose, California) |
| INVENTOR(S) | Robert Armitage (Cupertino, California) |
| ABSTRACT | Described are light emitting diode (LED) devices including a quantum well on a superlattice structure. The LED device has a dominant wavelength greater than 520 nm. The dominant wavelength changes less than 7 nm when the current density increases from 10 A/cm2 to 100 A/cm2 and a junction temperature of the device changes less than 20° C. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 18/280974 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) H01L 33/325 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297338 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ionblox, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingnan Dong (Fremont, California); Subramanian Venkatachalam (Charlotte, North Carolina); Herman A. Lopez (Sunnyvale, California) |
| ABSTRACT | Improved negative electrodes can comprise a silicon based active material blended with graphite to provide more stable cycling at high energy densities. In some embodiments, the negative electrodes comprise a blend of polyimide binder mixed with a more elastic polymer binder with a nanoscale carbon conductive additive. Electrolytes have been formulated that provide for extended cycling of cells incorporating a mixture of a silicon-oxide based active material with graphite active material in negative electrodes that can be matched with positive electrodes comprising nickel rich lithium nickel manganese cobalt oxides to cells with unprecedented cycling properties for large capacity cell based on a silicon negative electrode active material. |
| FILED | Tuesday, March 26, 2024 |
| APPL NO | 18/616531 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/386 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2004/028 (20130101) H01M 2300/0031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297341 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | Uchicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jiantao Li (Westmont, Illinois); Jiyu Cai (Willowbrook, Illinois); Zonghai Chen (Bolingbrook, Illinois) |
| ABSTRACT | A solid electrolyte includes a first inorganic solid electrolyte and a second inorganic electrolyte. The first inorganic electrolyte has a formula of Li3−yHyOX, where X is at least one halogen and 0<y≤1. The second inorganic solid electrolyte has an ionic conductivity greater than 0.01 mS/cm. The second inorganic solid electrolyte is dispersed in the first inorganic solid electrolyte, forming a composite inorganic solid electrolyte. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/115828 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/008 (20130101) H01M 2300/0071 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297471 | Stoll et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor T. Stoll (Excelsior Springs, Missouri); Michael E. Auxier (Olathe, Kansas) |
| ABSTRACT | A demating device configured to demate an electrical connector assembly having a first connector and a second connector is provided. The demating device may include a first separating member, a second separating member, and a gripping assembly. Actuation of the first separating member and the second separating member towards one another drives the jaws of the gripping assembly together, therein allowing secure gripping of the electrical connector assembly via the demating device for separation of the first and second connectors. |
| FILED | Thursday, April 25, 2024 |
| APPL NO | 18/646007 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/633 (20130101) H01R 43/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297501 | Griffith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Channing Street Copper Company (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saul Thomas Griffith (San Francisco, California); Samuel Eli Calisch (Berkeley, California); Joshua Land (San Francisco, California); Tucker Gilman (Berkeley, California) |
| ABSTRACT | An inductive stove appliance that includes a stove housing; a minimum of three cooking zones, with at least two of the cooking zones comprising induction coils; an electric oven; a set of cooktop and oven controls configured for operation of the inductive stove appliance, including operation of the minimum of three cooking zones and the electric oven; a power cord with a plug configured to couple with a standard 120V, 15 A-30 A, electrical power receptacle of a power distribution system; and a battery system disposed within the stove housing of the inductive stove appliance with one or more batteries integrated into the stove housing configured to: store power obtained from the power cord with the plug coupled with the electrical power receptacle of the power distribution system, power the minimum of three cooking zones of the inductive stove appliance, and power the electric oven of the inductive stove appliance. |
| FILED | Thursday, May 02, 2024 |
| APPL NO | 18/653681 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4207 (20130101) H01M 50/204 (20210101) H01M 50/251 (20210101) H01M 2220/10 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/32 (20130101) Original (OR) Class H02J 3/381 (20130101) H02J 7/0013 (20130101) H02J 7/00032 (20200101) H02J 7/0063 (20130101) H02J 7/342 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20240293377 | RISHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government As Represented By The Department Of Veterans Affairs (Washington, District of Columbia); Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ARUN K. RISHI (Troy, Michigan); NAVNATH GAVANDE (Detroit, Michigan) |
| ABSTRACT | Described herein are compositions and methods for treating cancer in a subject. The compositions include selective NF-κB inhibitor inhibitors. The methods include inhibiting the binding of CARP-1 with NEMO. |
| FILED | Wednesday, January 10, 2024 |
| APPL NO | 18/409703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/282 (20130101) A61K 31/427 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 31/4164 (20130101) A61K 47/557 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293430 | Mohapatra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhra Mohapatra (Lutz, Florida); Shyam MOHAPATRA (Lutz, Florida); Roukiah Khalil (Tampa, Florida) |
| ABSTRACT | The present disclosure provides methods of treating cancer in a subject in need thereof comprising administering to the subject a therapeutically effective amount of withaferin A and an immune checkpoint blocker. Further, the cancer to be treated may be resistant, have developed resistance, or may be susceptible to resistance to treatment with the immune checkpoint blocker alone or in combination with another therapeutic agent other than withaferin A. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/585 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293463 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Seattle Children’s Hospital DBA Seattle Children’s Research Institute (Seattle, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yvonne Y. Chen (Los Angeles, California); Eugenia Zah (Los Angeles, California); Michael C. Jensen (Seattle, Washington) |
| ABSTRACT | A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR. |
| FILED | Tuesday, April 23, 2024 |
| APPL NO | 18/643312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70596 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 16/2887 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293503 | HAWIGER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Jacek HAWIGER (Nashville, Tennessee); Jozef ZIENKIEWICZ (Nashville, Tennessee); Ruth Ann VEACH (Brentwood, Tennessee); Yan LIU (Nashville, Tennessee); Lukasz WYLEZINSKI (Nashville, Tennessee) |
| ABSTRACT | Disclosed are compositions and methods for treating microbial inflammation including its end-stage sepsis and conditions associated with the microbial inflammation such as thrombocytopenia and hypoglycogenemia. In one aspect, the compositions and methods disclosed herein can also be used to enhance clearance of microbes from infected tissues, organs, or systems in a subject. Also disclosed herein are compositions and methods for reducing levels of stress responsible transcription factors and metabolic transcription factors in a cell in a subject with microbial inflammation. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479600 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294925 | MOHAPATRA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhra MOHAPATRA (Tampa, Florida); Shyam MOHAPATRA (Tampa, Florida); Courtney PENN (Tampa, Florida) |
| ABSTRACT | Methods are disclosed for auditory dysfunction by administration of a therapeutic agent and stem cells. The therapeutic agent is chosen from disclosed agents that target the CCL20-CCR6 axis. Further disclosed are treatment protocols of said therapeutic agent and stem cells. The method of treatment is disclosed to be treatment following a traumatic brain injury. |
| FILED | Monday, March 04, 2024 |
| APPL NO | 18/594910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 45/06 (20130101) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294986 | Niculescu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Indiana Universityh Research and Technology Corporation (Bloomington, Indiana); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are novel compounds for treating and preventing schizophrenia, and more generally psychosis, by bioinformatics drug repurposing using novel genes expression biomarkers involved in psychotic symptoms (delusions, hallucinations); methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for psychosis in a subject; and method of using repurposed drugs and natural compounds to prevent and to treat psychosis. Methods are disclosed using a universal approach, in everybody, as well as personalized approaches by gender. The discovery describes compounds for use in everybody (universal), as well as personalized by gender (males, females). Methods for identifying which subjects should be receiving which treatment, using genes expression biomarkers for patient stratification and measuring response to treatment. The disclosure also relates to algorithms. The algorithms combine biomarkers as well as clinical measures for psychosis, to identify subjects who are at risk of psychosis, and to track responses to treatments. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 18/570890 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296928 | Gaweda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Adam E. Gaweda (Jeffersonville, Indiana); Michael E. Brier (Rossville, Tennessee); George R. Aronoff (Englewood, Colorado); Alfred A. Jacobs (Louisville, Kentucky) |
| ABSTRACT | A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/663322 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) Original (OR) Class G16H 50/20 (20180101) G16H 50/50 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20240292833 | Kaeppler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn Kaeppler (Middleton, Wisconsin); Heidi Kaeppler (Middleton, Wisconsin); Michael William Petersen (Merrimac, Wisconsin); Brian Joseph Martinell (Mount Horeb, Wisconsin); Frank McFarland (Middleton, Wisconsin) |
| ABSTRACT | The present invention provides pollen compositions, methods and kits for making said compositions, and methods of using said compositions to fertilize a plant. The pollen within these compositions has increased longevity and can be used to fertilize plants for an extended period of time as compared to pollen prepared using conventional methods. Also provided are methods of collecting pollen from a maize plant by maturing individual tassel branches off of the plant and vessels for collecting the pollen from these individual branches. |
| FILED | Tuesday, April 30, 2024 |
| APPL NO | 18/650704 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/10 (20130101) A01H 6/4684 (20180501) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240292836 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AIJUN ZHANG (LAUREL, Maryland); CODY GALE (ROCKVILLE, Maryland); EDMUND J. NORRIS (GAINSVILLE, Florida) |
| ABSTRACT | The disclosure provides evaluation of the spatial and topical repellent and knockdown activities of benzoates against blood-sucking arthropods and compared with DEET using both high-throughput in vitro screening tests and arm-in-cage in vivo assays in the laboratory. Tested alone or in blends were methyl benzoate (MB), ethyl benzoate (EB), vinyl benzoate (VB), n-propyl benzoate (nPrB), n-butyl benzoate (nBB), benzyl benzoate (BB), methyl 2-chlorobenzoate (M2CB), methyl 2-nitrobenzoate (M2NB), iso-butyl benzoate (iBB), n-pentyl benzoate (nPeB), n-hexyl benzoate (nHB), methyl 3-methylbenzoate (M3MB), iso-pentyl benzoate (also called iso-amyl benzoate) (iPeB), iso-propyl benzoate (iPrB), methyl 2-methoxybenzoate (M2MOB), ethyl 2-methoxybenzoate (E2MOB), ethyl 4-methoxybenzoate (E4MOB), methyl anthranilate (MA), Methyl 2-(aminosulfonyl)benzoate (M2ASB), n-butyl anthranilate (nBA), methyl 3-nitrobenzoate (M3NB), methyl 4-nitrobenzoate (M4NB), ethyl 3-aminobenzoate (E3AB), allyl anthranilate (AA), methyl 2-methylbenzoate (M2MB), methyl 3-methoxybenzoate (M3MOB), ethyl anthranilate (EA), methyl N-methylanthranilate (MMA), methyl N,N-dimethylanthranilate (MDMA), iso-butyl anthranilate (iBA), methyl N-acetylanthranilate (MAcA), methyl N-formylanthranilate (MFA), ethyl N-formylanthranilate (EFA), n-Propyl N-formylanthranilate (nPrFA), or n-Butyl N-formylanthranilate (nBFA). |
| FILED | Tuesday, February 27, 2024 |
| APPL NO | 18/588691 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) A01N 37/10 (20130101) Original (OR) Class A01N 37/18 (20130101) A01N 43/40 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 7/00 (20210801) A01P 7/02 (20210801) A01P 7/04 (20210801) A01P 17/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294932 | Schmidt |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Monica Schmidt (Tucson, Arizona) |
| ABSTRACT | Maize is vital to both US agriculture and the economy. The US provides over half of the maize global market. In the US, field maize production is a $75B endeavor and comprises 95% of the total US grain production. Worldwide there is a net loss of 16 million tons of maize due to aflatoxin contamination. In the US alone, aflatoxin contamination of food/feed results in an estimated $52M-$1.68B agricultural loss every year. Aflatoxin contamination in crops, and subsequently livestock, threatens greater agricultural development, food security and human health. Elimination of aflatoxin is a critical economic and health issue in the US. The present invention features composition and methods for the degradation of aflatoxin in crops post-harvest. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 18/553953 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/58 (20130101) C12N 15/8234 (20130101) C12N 15/8243 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240294992 | CAPOBIANCO, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); UNIVERSITY OF VIRGINIA PATENT FOUNDATION (CHARLOTTESVILLE, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOSEPH A CAPOBIANCO, JR. (MARKETING, New York); JOSEPH LEE (FLEMINGTON, New Jersey); CHIN YI CHEN (HUNTINGDON VALLEY, Pennsylvania); YIPING HE (AMBLER, Pennsylvania); CHERYL M ARMSTRONG (ABINGTON, Pennsylvania); SUE A REED (MORGANTOWN, Pennsylvania); BRYAN BERGER (CHARLOTTESVILLE, Virginia) |
| ABSTRACT | Provided herein are compositions and methodologies for identifying microbes in biofilms and adhered to biotic and abiotic surfaces, utilizing enzymes that degrade biofilms and disperse aggregated clusters of microorganisms. Utilizing enzymes such as CAase to degrade biofilms, organisms released from biofilms are identified more readily than from untreated biofilms. Biofilms from a variety of sources, both biotic and abiotic, can be analyzed utilizing the present disclosure. |
| FILED | Tuesday, July 25, 2023 |
| APPL NO | 18/358437 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) C12Q 1/28 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 1/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296906 | Momeni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Babak Momeni (Cambridge, Massachusetts); Marco Zaccaria (Malden, Massachusetts); Natalie Sandlin (Watertown, Massachusetts) |
| ABSTRACT | A partner-assisted artificial selection (PAAS) approach, in which an assisting population acts as an intermediate to create feedback from the function of interest to the fitness of the producer. The selection for improved growth in this approach successfully leads to improved degradation performance, even in the presence of other sources of stochasticity. Successful implementation of PAAS evolves improved functions of interest such as detoxification of harmful compounds. |
| FILED | Wednesday, May 03, 2023 |
| APPL NO | 18/311385 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/40 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20240296977 | Woods |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mainstream Engineering Corporation (Rockledge, Florida) |
| ASSIGNEE(S) | Mainstream Engineering Corporation (Rockledge, Florida) |
| INVENTOR(S) | Benjamin S. Woods (Melbourne, Florida) |
| ABSTRACT | A structure fabricated of a zeolite-based paste with an intra-layer continuous wire embedded is disclosed. Vitally, the continuous wire is extended past the bounds of the structure's walls, creating bare wire leads that allow for connection to a power source for electrification. The structure is made of multiple layers stacked together, typically in an additive manufacturing (3D printing) process. Within this structure, at least one layer has an embedded wire running through at least some portion of it, and is equipped with two bare wire leads protruding from the structure. This wire is designed to act as a heating element for uniform Joule heating of the zeolite structure for reduced power consumption and temperature ramp-up time during a desorption process, as well as reduced system footprint and enhanced mechanical properties. The frequency of wire embedment (a wire embedded in every nth layer), the percentage of the embedded layer that contains the wire, and the wire gauge and material/composition can be modified for the desired application. |
| FILED | Friday, March 03, 2023 |
| APPL NO | 18/177836 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/08 (20130101) H01B 13/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297314 | SONWANE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Astrobotic Technology, Inc. (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHANDRASHEKHAR SONWANE (MOJAVE, California); GURJAP SINGH (UNIVERSITY PARK, Pennsylvania); LAURENCE PETER LOHMAN (MOJAVE, California); ALEXANDER RATTNER (UNIVERSITY PARK, Pennsylvania); MATTHEW KUHNS (MOJAVE, California) |
| ABSTRACT | Embodiments of various aspects described herein are directed to a metal oxidation warming system (MOWS), a hydrogen storage system, and a co-generation system. These systems include an enclosure subdivided into a plurality of compartments, a fluid reservoir connected to a fluid manifold, and a plurality of fluid conduits connected through an inlet to the fluid manifold. Compartments include an active metal that reacts with a fluid delivered through the inlets and produces heat and hydrogen gas, which can be captured for heat and for driving a fuel cell. |
| FILED | Thursday, February 24, 2022 |
| APPL NO | 18/278857 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/0278 (20130101) B01J 8/0285 (20130101) B01J 2208/00176 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) C01B 3/065 (20130101) Collection, Production or Use of Heat Not Otherwise Provided for F24V 30/00 (20180501) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0606 (20130101) H01M 8/04074 (20130101) H01M 8/04216 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297563 | Toliyat et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas); Board of Regents, The University of Texas System (Austin, Texas); US Army Research Laboratory (Adelphi, Maryland); US Hybrid Corporation (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamid A. Toliyat (College Station, Texas); Bryton Praslicka (College Station, Texas); Daniel Zamarron (Bryan State, Texas); Matthew C. Gardner (Dallas, Texas); Matthew C. Johnson (College Station, Texas); Abas Goodarzi (Rolling Hills, California); Enzo Bauk (Lakewood, California); Alex Nguyen (Fullerton, California); Shima Hasanpour (College Station, Texas); Godwin Yuan Duan (Plano, Texas); Salek Khan Richardson (Richarson, Texas) |
| ABSTRACT | Aspects of the disclosure relate to a cycloidal magnetic gear. The cycloidal magnetic gear includes an outer rotor. A plurality of magnetic pole pairs is disposed on an inner circumference of the outer rotor. A first, second, and third inner rotor is disposed within the outer rotor. The first, second, and third inner rotors includes a magnetic pole pairs disposed on an outer circumference thereof. The first inner rotor and the third inner rotor have a thickness of approximately half the thickness of the second inner rotor. The first inner rotor, the second inner rotor, and the third inner rotor balance moments acting on a drive shaft. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 18/273941 |
| CURRENT CPC | Dynamo-electric Machines H02K 16/00 (20130101) H02K 51/00 (20130101) Original (OR) Class H02K 2213/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20240293502 | Cadete Pires et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NovoBiotic Pharmaceuticals, LLC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana Cristina Cadete Pires (Cambridge, Massachusetts); Aranda Rae Duan (Medford, Massachusetts); Losee Lucy Ling (Arlington, Massachusetts) |
| ABSTRACT | The present invention provides pharmaceutical compositions of teixobactin that are capable of preventing gelation of teixobactin. The pharmaceutical compositions comprise teixobactin and a pegylated phospholipid. The present invention also provides methods of preparing the pharmaceutical compositions of teixobactin and methods of treating a subject using the pharmaceutical compositions of teixobactin. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654900 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/15 (20130101) Original (OR) Class A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240293870 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sentient Science Corporation (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingfu LIU (Prior Lake, Minnesota); Behrooz JALALAHMADI (Long Island City, New York); Ziye LIU (West Lafayette, Indiana); Andrew VECHART (Minnetrista, Minnesota); Xiawa WU (Erie, Pennsylvania) |
| ABSTRACT | A system and method of additive manufacturing is disclosed herein which when run or performed form a product with a powder-based additive manufacturing device by adding sequential layers of material on top of one another. As each sequential layer of material is added, the system and method can include monitoring the sequential layer with a defect analysis subsystem to detect whether the sequential layer has any defects. For a detected defect, it can be determined whether defect correction is required. For a required defect correction, one or more correction parameters for the required defect correction can be identified; and a correction command including the one or more correction parameters can be sent to the additive manufacturing device, the correction command causing the additive manufacturing device to help correct the detected defect in the sequential layer according to the correction parameters prior to moving on to a next sequential layer. |
| FILED | Tuesday, August 15, 2023 |
| APPL NO | 18/450018 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0093 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8851 (20130101) Image Data Processing or Generation, in General G06T 7/001 (20130101) G06T 2207/10048 (20130101) G06T 2207/30136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240296330 | Iandola et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tesla, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forrest Nelson Iandola (San Jose, California); Harsimran Singh Sidhu (Fremont, California); Yiqi Hou (Berkeley, California) |
| ABSTRACT | A neural network architecture is used that reduces the processing load of implementing the neural network. This network architecture may thus be used for reduced-bit processing devices. The architecture may limit the number of bits used for processing and reduce processing to prevent data overflow at individual calculations of the neural network. To implement this architecture, the number of bits used to represent inputs at levels of the network and the related filter masks may also be modified to ensure the number of bits of the output does not overflow the resulting capacity of the reduced-bit processor. To additionally reduce the load for such a network, the network may implement a “starconv” structure that permits the incorporation of nearby nodes in a layer to balance processing requirements and permit the network to learn from context of other nodes. |
| FILED | Tuesday, May 14, 2024 |
| APPL NO | 18/664035 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/575 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20240295518 | Potyrailo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York) |
| ABSTRACT | The techniques described herein provide sensing systems and methods that provide configurable sensitivity and extended dynamic range of gas measurements. The systems and methods apply dielectric excitation at two or more excitation frequencies to a sensing material via sensing electrodes. A linearity of the electrical signal is changed by changing the operation parameters of the gas sensing element of the sensor. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116162 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/44 (20130101) G01N 27/221 (20130101) Original (OR) Class G01N 27/227 (20130101) G01N 2027/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295536 | Potyrailo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radislav Alexandrovich Potyrailo (Niskayuna, New York); Janell Marie Crowder (Clifton Park, New York); Richard St. Pierre (Clifton Park, New York); Baokai Cheng (Niskayuna, New York) |
| ABSTRACT | A sensor device may include an electrochemical (EC) gas sensor, a metal-oxide semiconductor (MOS) gas sensor, and control circuitry. The control circuitry may provide EC excitation signals to the EC gas sensor, provide at least two MOS excitation signals to the MOS gas sensor, and detect at least two gases. The control circuitry may detect the gases based on receiving EC response signals from the at least one EC gas sensor based on providing the EC excitation signals, receiving MOS response signals from the MOS gas sensor based on providing the MOS excitation signals, determining a multivariate response pattern based on the EC response signals and the MOS response signals, and differentiating between the at least two gases in contact with the sensor device based on the multivariate response pattern. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/116174 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0006 (20130101) G01N 33/0062 (20130101) G01N 33/0068 (20240501) G01N 33/0073 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20240296368 | SEIF TABRIZI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as Represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Alireza SEIF TABRIZI (Adelphi, Maryland); Mohammad HAFEZI (Washington, District of Columbia); Yi-Kai LIU (Gaithersburg, Maryland) |
| ABSTRACT | A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix. |
| FILED | Friday, May 03, 2024 |
| APPL NO | 18/654208 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20240294413 | Whitehill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Richard Whitehill (Durham, North Carolina); Eben Daniel Thoma (Cary, North Carolina); Paul Lemieux (Cary, North Carolina); Mark Higuchi (Chapel Hill, North Carolina); Chelsea Berg (Durham, North Carolina); Brian K. Gullett (Durham, North Carolina); Erin Shields (Cary, North Carolina) |
| ABSTRACT | Apparatus and systems are provided for processing PFAS-contaminated waste via thermomechanochemical (TMC) processing. In one example, a system may include a TMC processing chamber including a milling system and coupled to a heating system, the heating system configured to co-operate with the milling system to process the waste material. A plurality of containers including the waste material in one or more of a liquid-solid state, a semi-wet or slurry solid state, and a dry solid state are coupled to the TMC chamber. |
| FILED | Monday, May 06, 2024 |
| APPL NO | 18/656518 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/40 (20220101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 11/004 (20130101) C02F 11/13 (20190101) C02F 11/18 (20130101) Original (OR) Class C02F 2101/36 (20130101) C02F 2303/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20240296415 | McLellan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles P. McLellan (Fairfax, Virginia); Venkat Mouli (Chantilly, Virginia) |
| ABSTRACT | A system and method for the use of geo-fences to coordinate and track delivery of items. In some embodiments, the system comprising a mobile delivery device comprising a vector calculation module configured to determine a motion vector associated with the mobile delivery device, a geo-location module configured to determine a geo-location associated with a mobile delivery device, and a geo-fence database configured to determine a size of at least one geo-fence associated with at least one location and determine whether the mobile delivery device is within the geo-fence. In some embodiments, the size of the geo-fence is determined at least in part on the motion vector determined by the vector calculation module. |
| FILED | Wednesday, May 08, 2024 |
| APPL NO | 18/658255 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) G06Q 10/08355 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/021 (20130101) H04W 4/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20240294530 | HOYT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA,ASREPRESENTED BY THE SECRETARY,DEPT. OFHEALTH AND HUMAN SERVICES (Bethesda, Maryland); KUROME THERAPEUTICS, INC. (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Bryan HOYT (Arlington, Virginia); Craig Joseph THOMAS (Gaithersburg, Maryland); Daniel T. STARCZYNOWSKI (Cincinnati, Ohio); Jan ROSENBAUM (Cincinnati, Ohio); Gavriel GRACIA MALDONADO (Cincinnati, Ohio) |
| ABSTRACT | Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 18/258586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/541 (20130101) A61K 31/635 (20130101) A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240295188 | SAPRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harsh Darshan SAPRA (Madison, Wisconsin); Sage KOKJOHN (Oregon, Wisconsin); Randy HESSEL (Madison, Wisconsin); Eri AMEZCUA CUELLAR (Madison, Wisconsin); David ROTHAMER (Madison, Wisconsin) |
| ABSTRACT | A compression ignition engine provides a main injector and a second pilot injector producing a spray passing over an igniter producing a pilot flame assisting in ignition of the main injector spray. |
| FILED | Wednesday, March 01, 2023 |
| APPL NO | 18/176787 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 9/04 (20130101) Original (OR) Class F02B 43/12 (20130101) F02B 69/04 (20130101) Ignition; Extinguishing-devices F23Q 7/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20240297651 | HALL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jeffrey S. HALL (Annapolis, Maryland); Jonathan D. EGAN (Hanover, Maryland); Joseph A. PAYNE (Cooksville, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | Jeffrey S. HALL (Annapolis, Maryland); Jonathan D. EGAN (Hanover, Maryland); Joseph A. PAYNE (Cooksville, Maryland) |
| ABSTRACT | One example includes a superconducting circuit chip. The chip includes superconducting circuitry that operates based on a clock signal. The chip also includes a ring oscillator configured to receive a synchronization signal from a ring oscillator associated with another superconducting circuit chip. The ring oscillator is also configured to provide a trigger signal to the superconducting circuitry at a given phase of the clock signal relative to a phase of the clock signal of a trigger signal associated with the other one of the superconducting circuit chips based on the synchronization signal. |
| FILED | Thursday, March 02, 2023 |
| APPL NO | 18/177299 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Pulse Technique H03K 3/0315 (20130101) H03K 17/92 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 05, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
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Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20240905.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page