FedInvent™ Patents

Patent Details for Tuesday, October 08, 2024 

This page was updated on Friday, October 11, 2024 at 06:27 PM GMT

Department of Health and Human Services (HHS) 

US 12108998 Hasser et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) INTUITIVE SURGICAL OPERATIONS, INC. (Sunnyvale, California);  The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) Intuitive Surgical Operations, Inc. (Sunnyvale, California);  The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Christopher J. Hasser (Los Altos, California);  Russell H. Taylor (Severna Park, Maryland);  Joshua Leven (San Francisco, California);  Michael Choti (Lutherville, Maryland)
ABSTRACT A LUS robotic surgical system is trainable by a surgeon to automatically move a LUS probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2D ultrasound image slices captured by the LUS probe according to stored instructions are processable into a 3D ultrasound computer model of an anatomic structure, which may be displayed as a 3D or 2D overlay to a camera view or in a PIP as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. Virtual fixtures are definable so as to assist the surgeon in accurately guiding a tool to a target on the displayed ultrasound image.
FILED Monday, June 12, 2023
APPL NO 18/332891
ART UNIT 2672 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/3132 (20130101)
A61B 8/00 (20130101)
A61B 8/12 (20130101)
A61B 8/461 (20130101)
A61B 8/4218 (20130101)
A61B 8/4245 (20130101)
A61B 34/25 (20160201)
A61B 34/30 (20160201)
A61B 34/37 (20160201) Original (OR) Class
A61B 34/70 (20160201)
A61B 34/76 (20160201)
A61B 90/03 (20160201)
A61B 90/37 (20160201)
A61B 90/361 (20160201)
A61B 2017/00203 (20130101)
A61B 2034/107 (20160201)
A61B 2034/305 (20160201)
A61B 2090/364 (20160201)
A61B 2090/365 (20160201)
A61B 2090/378 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109131 Sanders et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Joan E. Sanders (Seattle, Washington);  Joseph L. Garbini (Seattle, Washington);  Jake McLean (Seattle, Washington);  Jacob Brzostowski (Seattle, Washington);  Christian B. Redd (Seattle, Washington);  John Cagle (Seattle, Washington);  Samuel Bennett (Seattle, Washington);  Horace Wang (Seattle, Washington);  Ethan Weathersby (Seattle, Washington);  Andrew Vamos (Seattle, Washington)
ABSTRACT The disclosure provides example apparatus and methods for automatically adjusting a socket size of a prosthesis. The apparatus includes (a) the prosthesis having a socket configured to receive a limb, (b) a first opening in a socket wall, (c) a first panel aligned with the first opening, (d) a first actuator coupled to the first panel and to the prosthesis, the first actuator is configured to advance and retract the first panel, (e) a first sensor coupled to the socket wall and configured to obtain limb-to-socket gap data, and (f) a processor coupled to the first actuator and the first sensor, wherein the processor is configured (i) to receive the limb-to-socket gap data, (ii) to determine a socket-size adjustment based on the limb-to-socket gap data and a predetermined socket-fit value, (iii) to generate and (iv) to send a command with the socket-size adjustment to the first actuator.
FILED Friday, May 01, 2020
APPL NO 16/865088
ART UNIT 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/70 (20130101)
A61F 2/76 (20130101) Original (OR) Class
A61F 2/80 (20130101)
A61F 2002/701 (20130101)
A61F 2002/704 (20130101)
A61F 2002/762 (20130101)
A61F 2002/5027 (20130101)
A61F 2002/6863 (20130101)
A61F 2002/7818 (20130101)
A61F 2002/7875 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109177 Bai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Renyuan Bai (Baltimore, Maryland);  Verena Staedtke (Baltimore, Maryland)
ABSTRACT Provided herein are methods for increasing the therapeutic efficiency of oncolytic bacterial therapeutics. Bacterial oncolytic therapies, especially the ones targeting tumor hypoxia such as C. novyi-NT, often encounter incomplete tumor clearance in less hypoxic tumoral areas and severe inflammatory reactions. In this study, we explored immune-modulating preconditioning to suppress the host neutrophils and significantly enhanced the antitumor efficacy of C. novyi-NT in animal models, including an orthotopic brain tumor model in rabbits. The optimized preconditioning agent, hydroxyurea, is clinically approved and C. novyi-NT has demonstrated manageable safety and promising antitumor responses in clinical trials. Thus, the proposed preconditioning of neutrophil suppression is readily translatable to patients undergoing C. novyi-NT trials or other oncolytic biologic therapies and could improve outcome.
FILED Tuesday, December 20, 2022
APPL NO 18/085467
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/133 (20130101) Original (OR) Class
A61K 31/535 (20130101)
A61K 35/742 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109187 Horzempa et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) WEST LIBERTY UNIVERSITY (West Liberty, West Virginia);  UNIVERSITY OF MISSISSIPPI (University, Mississippi)
ASSIGNEE(S) West Liberty University (West Liberty, West Virginia);  University of Mississippi (University, Mississippi)
INVENTOR(S) Joseph A. Horzempa (Pittsburgh, Pennsylvania);  Elliot M. Collins (Crooksville, Ohio);  Juan Francisco Leon (Gainesville, Florida)
ABSTRACT A pharmaceutical composition is provided that comprises an effective amount of dillapiole or a derivative thereof, and a pharmaceutically-acceptable vehicle, carrier, or excipient. Methods of treating a bacterial infection are also described and include administering an effective amount of dillapiole or a derivative thereof to a subject in need of such treatment. Methods of reducing bacterial virulence are further described and include contacting a bacterium, such as a F. tularensis or A. baumannii bacterium, with an effective amount of dillapiole or a derivative thereof.
FILED Friday, August 06, 2021
APPL NO 17/396223
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/09 (20130101)
A61K 31/36 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109204 Crosbie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Rachelle H. Crosbie (Sherman Oaks, California);  Cynthia Shu (Oakland, California)
ABSTRACT Provided herein are methods for treating and preventing a disease related to diminution or dysfunction of a dystrophin-related complex in a subject in need thereof, comprising administering to the subject a compound that increases sarcospan. Also provided herein are pharmaceutical compositions comprising a compound that increases sarcospan, or a pharmaceutically acceptable salt or ester thereof, useful for the treatments described herein.
FILED Wednesday, June 05, 2019
APPL NO 16/972184
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/40 (20130101)
A61K 31/137 (20130101)
A61K 31/404 (20130101)
A61K 31/427 (20130101)
A61K 31/439 (20130101)
A61K 31/498 (20130101)
A61K 31/522 (20130101)
A61K 31/525 (20130101)
A61K 31/565 (20130101)
A61K 31/4418 (20130101)
A61K 31/4422 (20130101)
A61K 31/4439 (20130101) Original (OR) Class
A61K 31/7076 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109224 Parker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado);  Washington University (St. Louis, Missouri)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado);  WASHINGTON UNIVERSITY (St. Louis, Missouri)
INVENTOR(S) Roy R. Parker (Boulder, Colorado);  Siddharth Shukla (Boulder, Colorado);  Luis F. Z. Batista (Clayton, Missouri);  Hochang Jeong (St. Louis, Missouri)
ABSTRACT The invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of USB1 and resulting expression of downstream miRNAs. In one preferred embodiment, the invention may include inhibiting the expression or activity of USB1 resulting in the downregulation of downstream miRNA expression. In alternative embodiments, the invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of miRNAs downstream of USB1, namely through the inhibition of PAPD5 and/or PAPD7, resulting in the upregulation of said downstream miRNA expression.
FILED Friday, September 03, 2021
APPL NO 17/466448
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 31/4375 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109225 Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) GLYCOMIRA THERAPEUTICS, INC. (Salt Lake City, Utah)
ASSIGNEE(S) GLYCOMIRA THERAPEUTICS, INC. (Salt Lake City, Utah)
INVENTOR(S) Won Yong Lee (Bountiful, Utah);  Thomas P. Kennedy (Williamsburg, Virginia);  Glenn D. Prestwich (Spokane, Washington)
ABSTRACT Described herein are methods for reducing or maintaining the size of a tumor in a subject, where the method involves exposing the tumor to ionizing radiation and administering to the subject a modified hyaluronan or a pharmaceutically acceptable salt or ester. The use of the modified hyaluronan enhances or potentiates the effect of ionizing radiation used in cancer treatment. Additionally, the methods described herein prevent or reduces tumor regrowth in the subject after exposing the tumor to ionizing radiation and administration of the modified hyaluronan to the subject.
FILED Monday, November 11, 2019
APPL NO 17/293103
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/737 (20130101) Original (OR) Class
A61K 41/0038 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/1001 (20130101)
A61N 5/1077 (20130101)
A61N 5/1084 (20130101)
A61N 2005/109 (20130101)
A61N 2005/1024 (20130101)
A61N 2005/1087 (20130101)
A61N 2005/1091 (20130101)
A61N 2005/1098 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109236 Miller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S) Jeffrey Steven Miller (Minneapolis, Minnesota);  Frank Martin Cichocki (Minneapolis, Minnesota)
ABSTRACT Provided herein are methods of manipulating ARID5B expression in immune cells such NK cells, T cells, and T cell and NK cell progenitors to enhance their persistence and function in vivo. Also provided herein are modified immune cells and compositions comprising such modified cells for anti-cancer, anti-viral, and other immunotherapies. In some embodiments, immune cells are genetically modified to increase ARID5B expression and, thus, improve persistence, increase in vivo anti-tumor efficacy, and increase viability and functionality of the modified cells after freezing and thawing.
FILED Wednesday, May 08, 2019
APPL NO 17/055525
ART UNIT 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Peptides
C07K 14/47 (20130101)
C07K 14/7051 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0646 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109237 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Dongfang Liu (Millburn, New Jersey);  Minh Ma (New Brunswick, New Jersey);  Saiaditya Badeti (New Brunswick, New Jersey)
ABSTRACT Chimeric antigen receptors (CARs) including an scFv binding to coronavirus spike protein (S309 scFv), nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and cells expressing the CARs are provided. Methods of treating a subject with coronavirus are also provided, including administering to the subject a modified immune cell expressing a disclosed CAR.
FILED Tuesday, December 14, 2021
APPL NO 17/551006
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 38/00 (20130101)
A61K 39/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/5443 (20130101)
C07K 14/7051 (20130101)
C07K 14/7151 (20130101)
C07K 14/70521 (20130101)
C07K 16/10 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109242 Kim et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S) THE CHILDREN'S MEDICAL CENTER CORPORATION (, None)
INVENTOR(S) Carla F. Kim (Boston Charlestown, Massachusetts);  Sharon M. Louie (Boston, Massachusetts);  Erhan Ararat (Boston, Massachusetts);  David Raiser (Boston, Massachusetts)
ABSTRACT Various aspects described herein provide methods of generating alveolar or alveolar/airway organoids from a population of lung cells to differentiate into alveolar or alveolar/airway organoids. Also provided herein are methods and compositions for treating lung disease comprising transplantation of the alveolar or alveolar/airway organoids, or a cell isolated therefrom to a subject.
FILED Monday, October 19, 2020
APPL NO 17/074118
ART UNIT 1759 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0271 (20130101)
A01K 2207/12 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0337 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/007 (20130101)
A61K 9/0073 (20130101)
A61K 35/42 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 49/0008 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0688 (20130101)
C12N 5/0697 (20130101)
C12N 2506/02 (20130101)
C12N 2506/27 (20130101)
C12N 2506/45 (20130101)
C12N 2513/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109249 Egilmez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
ASSIGNEE(S) University of Louisville Research Foundation (Louisville, Kentucky)
INVENTOR(S) Nejat Egilmez (Louisville, Kentucky);  Neal Bhutiani (Louisville, Kentucky)
ABSTRACT Compositions and methods for the treatment of cancer and/or inflammatory diseases are provided. A combination of interleukin-10 (IL-10) and interleukin-12 (IL-12) is used to treat cancer and/or inflammatory diseases, and a combination of an anti-PD-1 antibody and an anti-IL-17 antibody is used to treat cancer.
FILED Tuesday, January 29, 2019
APPL NO 16/965797
ART UNIT 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/208 (20130101)
A61K 38/2066 (20130101) Original (OR) Class
A61K 2039/507 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/244 (20130101)
C07K 16/2818 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109256 Weichert et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Jamey Weichert (Sun Prairie, Wisconsin);  Paul M. Sondel (Madison, Wisconsin);  Anatoly Pinchuk (Fitchburg, Wisconsin);  Zachary Morris (Madison, Wisconsin);  Mario Otto (Fitchburg, Wisconsin);  Bryan Bednarz (Madison, Wisconsin)
ABSTRACT A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula:
wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
FILED Thursday, July 02, 2020
APPL NO 16/919191
ART UNIT 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/001 (20130101) Original (OR) Class
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/39558 (20130101)
A61K 51/041 (20130101)
A61K 51/0408 (20130101)
A61K 51/0489 (20130101)
A61K 2039/53 (20130101)
A61K 2039/58 (20130101)
A61K 2039/505 (20130101)
A61K 2039/545 (20130101)
A61K 2039/572 (20130101)
A61K 2039/585 (20130101)
A61K 2039/55511 (20130101)
A61K 2039/55533 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109260 Livengood et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) TAKEDA VACCINES, INC. (Cambridge, Massachusetts)
ASSIGNEE(S) Takeda Vaccines, Inc. (Cambridge, Massachusetts)
INVENTOR(S) Jill A Livengood (Cambridge, Massachusetts);  Hansi Dean (Cambridge, Massachusetts);  Htay Htay Han (Cambridge, Massachusetts);  Raman Rao (Singapore, Singapore);  Jackie Marks (Cambridge, Massachusetts);  Gary Dubin (Zurich, Switzerland);  Laurence De Moerlooze (Zurich, Switzerland);  Hetal Patel (Cambridge, Massachusetts);  Sushma Kommareddy (Cambridge, Massachusetts)
ABSTRACT The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
FILED Friday, June 16, 2023
APPL NO 18/336439
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 39/12 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 2039/54 (20130101)
A61K 2039/545 (20130101)
A61K 2039/5252 (20130101)
A61K 2039/55505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/24034 (20130101)
C12N 2770/24071 (20130101)
C12N 2770/24134 (20130101)
C12N 2770/24151 (20130101)
C12N 2770/24163 (20130101)
C12N 2770/24164 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109266 Anderson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Kenneth C. Anderson (Wellesley, Massachusetts);  Annamaria Gullà (Boston, Massachusetts)
ABSTRACT The present invention relates, in part, to methods of inducing immunogenic cell death to treat a cancer in a subject comprising administering to the subject a therapeutically effective amount of an agent that increases one or more biomarkers listed in Table 1 in combination with an inducer of immunogenic cell death (ICD).
FILED Wednesday, November 03, 2021
APPL NO 17/518272
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39558 (20130101) Original (OR) Class
A61K 2039/505 (20130101)
A61K 2039/572 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/04 (20180101)

Peptides
C07K 16/2818 (20130101)
C07K 2317/21 (20130101)
C07K 2317/52 (20130101)
C07K 2317/76 (20130101)
C07K 2317/732 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109268 Thyagarajan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF WYOMING (Laramie, Wyoming)
ASSIGNEE(S) UNIVERSITY OF WYOMING (Laramie, Wyoming)
INVENTOR(S) Baskaran Thyagarajan (Laramie, Wyoming);  Padmamalini Baskaran (Laramie, Wyoming)
ABSTRACT A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.
FILED Monday, July 26, 2021
APPL NO 17/384958
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0053 (20130101)
A61K 9/5031 (20130101)
A61K 9/5094 (20130101)
A61K 9/5153 (20130101)
A61K 31/23 (20130101)
A61K 31/165 (20130101)
A61K 31/231 (20130101)
A61K 31/357 (20130101)
A61K 31/7034 (20130101)
A61K 41/00 (20130101) Original (OR) Class
A61K 41/0052 (20130101)
A61K 47/02 (20130101)
A61K 47/6941 (20170801)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/773 (20130101)
Y10S 977/906 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109271 Avram et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
INVENTOR(S) Dorina Avram (Tampa, Florida);  Benjamin George Keselowsky (Gainesville, Florida);  Joshua Stewart (Gainesville, Florida);  Jonathan Joseph Cho (Gainesville, Florida)
ABSTRACT Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosable and non-phagocytosable microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant to a subject suffering from Multiple Sclerosis to generate tolerogenic dendritic cells in the subject and treat the Multiple Sclerosis.
FILED Wednesday, July 03, 2019
APPL NO 17/257731
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/203 (20130101)
A61K 31/436 (20130101)
A61K 31/593 (20130101)
A61K 38/193 (20130101)
A61K 38/1841 (20130101)
A61K 38/1866 (20130101)
A61K 38/2066 (20130101)
A61K 39/0008 (20130101)
A61K 47/593 (20170801) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109311 Slocum et al.
FUNDED BY
Department of Health and Human Services (HHS)
Food and Drug Administration (FDA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Alexander H. Slocum (Bow, New Hampshire);  Bernhardt Levy Trout (Lexington, Massachusetts)
ABSTRACT System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.
FILED Friday, June 25, 2021
APPL NO 17/359394
ART UNIT 3753 — Fluid Handling and Dispensing
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/19 (20130101) Original (OR) Class

Drying Solid Materials or Objects by Removing Liquid Therefrom
F26B 5/06 (20130101)

Electric Machines Not Otherwise Provided for
H02N 15/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109440 Bar-Zion et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S) Avinoam D. Bar-Zion (Pasadena, California);  Atousa Nourmahnad (Pasadena, California);  David Maresca (Pasadena, California);  Mikhail Shapiro (Pasadena, California)
ABSTRACT The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
FILED Friday, July 29, 2022
APPL NO 17/816373
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 7/00 (20130101) Original (OR) Class
A61N 2007/0004 (20130101)
A61N 2007/0039 (20130101)
A61N 2007/0052 (20130101)
A61N 2007/0082 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109510 Kolesnichenko et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Institute on Minority Health and Health Disparities (NIMHD)
Research Centers in Minority Institutions Program (RCMI)
APPLICANT(S) Xavier University of Louisiana (New Orleans, Louisiana)
ASSIGNEE(S) Xavier University of Louisiana (New Orleans, Louisiana)
INVENTOR(S) Vladimir Kolesnichenko (New Orleans, Louisiana);  Galina Goloverda (New Orleans, Louisiana);  Igor Kolesnichenko (New Orleans, Louisiana);  Guangdi Wang (New Orleans, Louisiana)
ABSTRACT Disclosed are methods of solvent removal in an evacuated, closed system at ambient or low (spontaneously dropped due to evaporation endothermicity) temperature. The methods disclosed are suitable for removing the solvents with a broad range of volatility, having normal (STP) boiling points from 30 up to at least 202° C. (vapor pressures at least of 0.1 to 500 torr; higher boiling point solvents are possible to remove with longer experimental times) and is only limited from a volume standpoint by the size of the apparatus used.
FILED Thursday, December 10, 2020
APPL NO 17/118319
ART UNIT 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Separation
B01D 3/10 (20130101)
B01D 11/0492 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110278 Jorgensen et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
NIH Office of the Director (NIHOD)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) William L. Jorgensen (Deep River, Connecticut);  Joseph Schlessinger (Woodbridge, Connecticut)
ABSTRACT The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I.
FILED Wednesday, October 13, 2021
APPL NO 17/500622
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4196 (20130101)
A61K 31/4245 (20130101)
A61K 31/4439 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 249/14 (20130101) Original (OR) Class
C07D 401/12 (20130101)
C07D 405/12 (20130101)
C07D 413/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110292 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Nathanael Gray (Stanford, California);  Tinghu Zhang (Brookline, Massachusetts);  Eric Fischer (Chestnut Hill, Massachusetts);  Zhixiang He (Brookline, Massachusetts);  Guangyan Du (Jamaica Plain, Massachusetts);  Katherine Donovan (Boston, Massachusetts);  Radoslaw Nowak (Boston, Massachusetts);  Jing Ting Christine Yuan (Baltimore, Maryland)
ABSTRACT Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.
FILED Friday, November 11, 2022
APPL NO 17/985415
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 405/14 (20130101)
C07D 473/16 (20130101) Original (OR) Class
C07D 473/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110313 Hecht et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Sidney Hecht (Phoenix, Arizona);  Larisa Dedkova (Scottsdale, Arizona);  Shengxi Chen (Chandler, Arizona);  Xiaoguang Bai (Scottsdale, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S) Sidney Hecht (Phoenix, Arizona);  Larisa Dedkova (Scottsdale, Arizona);  Shengxi Chen (Chandler, Arizona);  Xiaoguang Bai (Scottsdale, Arizona)
ABSTRACT Compositions and methods relating to bacterial ribosomes selected to increase the incorporation of at least one glycosylated amino acid into a protein versus a wild-type bacterial ribosome. Selection embodiments include growing bacteria in the presence of a puromycin derivative, wherein a surviving clone has a ribosome that incorporates at least one glycosylated amino acid into a protein.
FILED Friday, February 28, 2020
APPL NO 16/804691
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 19/16 (20130101)

Peptides
C07K 14/001 (20130101) Original (OR) Class
C07K 14/565 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110320 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S) Samuel Lai (Carrboro, North Carolina);  M. Gregory Forest (Chapel Hill, North Carolina);  Christine Henry (Chapel Hill, North Carolina);  Timothy Wessler (Durham, North Carolina);  Alexander Chen (Glenville, New York);  Jennifer Schiller (Chapel Hill, North Carolina);  Jay Newby (Carrboro, North Carolina)
ABSTRACT The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.
FILED Friday, March 18, 2022
APPL NO 17/698645
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)

Peptides
C07K 16/44 (20130101)
C07K 16/087 (20130101)
C07K 16/1045 (20130101)
C07K 16/1235 (20130101) Original (OR) Class
C07K 2317/41 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/557 (20130101)
G01N 33/6854 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2333/16 (20130101)
G01N 2333/4725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110331 Mason et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  VETIGENICS, INC. (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania);  Vetigenics, Inc. (Philadelphia, Pennsylvania)
INVENTOR(S) Nicola J. Mason (Philadelphia, Pennsylvania);  Donald L. Siegel (Lansdale, Pennsylvania);  Nicholas Chester (Philadelphia, Pennsylvania)
ABSTRACT The present invention relates to canine antibodies, binding polypeptides, and scFvs specific for canine cytotoxic T lymphocyte associated protein 4 (CTLA-4).
FILED Friday, October 20, 2023
APPL NO 18/491182
ART UNIT 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/2818 (20130101) Original (OR) Class
C07K 2317/20 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110333 Blumberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S) THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (, None)
INVENTOR(S) Richard S. Blumberg (Waltham, Massachusetts);  Kristi Baker (Edmonton, Canada);  Michal Pyzik (Cambridge, Massachusetts);  Amit Gandhi (Billerica, Massachusetts)
ABSTRACT As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.
FILED Monday, February 25, 2019
APPL NO 16/284005
ART UNIT 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

Peptides
C07K 16/44 (20130101)
C07K 16/283 (20130101) Original (OR) Class
C07K 2317/76 (20130101)
C07K 2317/77 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110334 Nishimura et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Stephen L. Nishimura (San Francisco, California);  Jianlong Lou (San Francisco, California);  James D. Marks (San Francisco, California);  Jody L. Baron (San Francisco, California);  Yifan Cheng (San Francisco, California);  Shenping Wu (San Francisco, California);  Anthony Cormier (San Francisco, California);  Naoki Takasaka (San Francisco, California)
ABSTRACT New antibodies and methods of use are described.
FILED Wednesday, January 11, 2023
APPL NO 18/153277
ART UNIT 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/04 (20180101)
A61P 31/20 (20180101)
A61P 35/04 (20180101)
A61P 37/04 (20180101)

Peptides
C07K 14/705 (20130101)
C07K 16/22 (20130101)
C07K 16/2839 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/34 (20130101)
C07K 2317/56 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/622 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110490 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts);  PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Feng Zhang (Cambridge, Massachusetts);  Bernd Zetsche (Gloucester, Massachusetts);  Fei Ran (Boston, Massachusetts);  James E. Dahlman (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
FILED Friday, December 16, 2016
APPL NO 16/063643
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/102 (20130101)
C12N 15/111 (20130101) Original (OR) Class
C12N 15/902 (20130101)
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110499 Scharenberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Seattle Children's Hospital (Seattle, Washington);  Fred Hutchinson Cancer Center (Seattle, Washington)
ASSIGNEE(S) Seattle Children's Hospital (Seattle, Washington)
INVENTOR(S) Andrew Scharenberg (Seattle, Washington);  Kyle Jacoby (Seattle, Washington);  Hans-Peter Kiem (Seattle, Washington);  David J. Rawlings (Seattle, Washington);  Christopher Lux (Bremerton, Washington);  Sowmya Pattabhi (Bellevue, Washington);  Olivier M. Humbert (Seattle, Washington)
ABSTRACT The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.
FILED Tuesday, April 24, 2018
APPL NO 16/608182
ART UNIT 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/00 (20180101)

Peptides
C07K 14/805 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101)
C12N 15/86 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2750/14143 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110504 Siprashvili et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  The United States Government as represented by the Department of Veterans Affairs (Washington, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Zurab Siprashvili (San Mateo, California);  Ngon T. Nguyen (Union City, California);  M. Peter Marinkovich (Redwood City, California);  Jean Tang (Stanford, California);  Alfred T. Lane (Los Altos, California);  Paul A. Khavari (Palo Alto, California)
ABSTRACT Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
FILED Friday, November 03, 2023
APPL NO 18/501837
ART UNIT 1638 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/0058 (20130101)
A61K 48/0075 (20130101)
A61K 48/0091 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0629 (20130101) Original (OR) Class
C12N 2510/00 (20130101)
C12N 2760/16043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110522 Branon et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Tess Branon (Stanford, California);  Alice Y. Ting (Stanford, California)
ABSTRACT Engineered promiscuous biotin ligases and methods of using them in proximity labeling are described. In particular, the invention provides novel biotin ligase variants having increased promiscuous biotinylation activity capable of proximity labeling of proteins in live cells in as little as 10 minutes.
FILED Friday, January 11, 2019
APPL NO 16/962792
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101) Original (OR) Class

Enzymes
C12Y 603/04015 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/58 (20130101)
G01N 33/6842 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110523 Raines et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Ronald T. Raines (Madison, Wisconsin);  Kalie Mix (Madison, Wisconsin)
ABSTRACT Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I:
where R is hydrogen, an alkyl, an alkenyl or an alkynyl, RA represents 1-5 substituents on the indicated phenyl ring and RM is an organic group. RM includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond to a label, a cell penetrating group, or a cell targeting group, among other organic groups useful for esterification of biological molecules. Also provided are diazo compounds which are bifunctional and trifunctional coupling reagents as well as reagents for the synthesis of compounds of formula I.
FILED Monday, November 15, 2021
APPL NO 17/526816
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 231/12 (20130101)
C07C 231/12 (20130101)
C07C 235/34 (20130101)
C07C 245/18 (20130101)
C07C 269/06 (20130101)
C07C 269/06 (20130101)
C07C 271/22 (20130101)
C07C 319/12 (20130101)
C07C 319/12 (20130101)
C07C 323/52 (20130101)

Heterocyclic Compounds
C07D 207/46 (20130101)

Peptides
C07K 1/13 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/96 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110542 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Fogarty International Center (FIC)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S) UNIVERSITY OF CONNECTICUT (Farmington, Connecticut)
INVENTOR(S) Changchun Liu (Farmington, Connecticut);  Xiong Ding (Farmington, Connecticut)
ABSTRACT Disclosed herein are “dual-priming” isothermal amplification method (including “self-priming” and “pairing-priming” strand extension, termed “DAMP”) for rapid nucleic acid detection.
FILED Friday, September 10, 2021
APPL NO 17/472300
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6855 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110553 Pollak et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Brigham and Women's Hospital, Inc. (Boston, Massachusetts);  Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S) The Brigham and Women's Hospital, Inc. (Boston, Massachusetts);  Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S) Martin Pollak (Brookline, Massachusetts);  Elizabeth J. Brown (Dallas, Texas);  Johannes Schlondorff (Chestnut Hill, Massachusetts)
ABSTRACT This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided.
FILED Monday, December 07, 2020
APPL NO 17/113957
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/68 (20130101)
C12Q 1/6811 (20130101)
C12Q 1/6813 (20130101)
C12Q 1/6816 (20130101)
C12Q 1/6827 (20130101)
C12Q 1/6876 (20130101)
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 1/6886 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/118 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6854 (20130101)
G01N 33/6893 (20130101)
G01N 2800/347 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110555 Targan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
ASSIGNEE(S) CEDARS-SINAI MEDICAL CENTER (Los Angeles, California)
INVENTOR(S) Stephan R. Targan (Santa Monica, California);  Marla C. Dubinsky (Los Angeles, California);  Carol J. Landers (Los Angeles, California);  Ling Mei (Pasadena, California);  Jerome I. Rotter (Los Angeles, California);  Kent D. Taylor (Ventura, California)
ABSTRACT This invention provides methods of diagnosis, predicting and diagnosing susceptibility to, predicting disease progression and treatment of inflammatory bowel disease (IBD), including Crohn's disease and/or subtypes of Crohn's disease (CD) and/or Ulcerative Colitis (UC). In one embodiment, a method of the invention is practiced by determining the presence or absence of the genetic variants NOD2, TLR8, TLR2, CARD8, CARD15 and/or JAK3 to diagnose, predict and diagnose susceptibility and predict disease progression in an individual. In another embodiment, a method of the invention is practiced by determining the presence or absence of anti-Cbir1, anti-OmpC, ASCA, anti-I2 and/or pANCA in an individual. In another embodiment, the invention further associates the presence or absence of the risk variants with the expression of anti-Cbir1, anti-OmpC, ASCA, anti-I2 and/or pANCA for the diagnosis, prediction of susceptibility, prediction of disease progression and/or treatment of IBD, including CD and/or UC.
FILED Friday, January 28, 2022
APPL NO 17/588089
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/156 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101)
G01N 2800/50 (20130101)
G01N 2800/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110564 Foxman
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Ellen Foxman (West Hartford, Connecticut)
ABSTRACT In one aspect the invention provides a method for distinguishing between a viral-only infection of the upper respiratory tract or a bacterial or viral/bacterial coinfection in a patient by analyzing a respiratory sample.
FILED Monday, May 06, 2019
APPL NO 17/052882
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/70 (20130101) Original (OR) Class
C12Q 1/689 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56911 (20130101)
G01N 33/56983 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111241 Hering et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
National Institute for Occupational Safety and Health (NIOSH)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) Aerosol Dynamics Inc. (Berkeley, California)
ASSIGNEE(S) Aerosol Dynamics Inc. (Berkeley, California)
INVENTOR(S) Susanne Vera Hering (Berkeley, California);  Gregory Stephen Lewis (Berkeley, California);  Steven Russel Spielman (Oakland, California)
ABSTRACT A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber connected to an optical detector and an outlet by pumping at the outlet. The method further includes passing air through the chamber and optical detector in a steady flow, and subsequently closing the inlet while continuing the pumping to expand the air sample and exhaust a portion of the air sample through the optical detector. The walls of the particle chamber are wetted with a fluid such as water, and one portion of the wall is warmer than the other portions such that there is some condensational growth prior to the expansion, and yet more condensational growth during the expansion. The cycles are repeated by continuously repeating the introducing, passing and closing.
FILED Wednesday, January 05, 2022
APPL NO 17/568940
ART UNIT 2877 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/06 (20130101) Original (OR) Class
G01N 15/075 (20240101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111317 Chodosh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) Lewis Chodosh (West Chester, Pennsylvania);  Elizabeth Chislock (Media, Pennsylvania)
ABSTRACT The present invention provides compositions and methods for detecting and isolating disseminated tumor cells (DTCs) from breast cancer in a bone marrow aspirate of a subject. The invention further provides methods of treating breast cancer in the subject.
FILED Friday, June 08, 2018
APPL NO 16/620580
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0058 (20130101)

Peptides
C07K 16/32 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/01 (20240101)
G01N 15/10 (20130101)
G01N 15/1459 (20130101)
G01N 33/57415 (20130101) Original (OR) Class
G01N 2015/1006 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111322 Li et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Lingjun Li (Madison, Wisconsin);  Yatao Shi (Arlington, Massachusetts);  Zihui Li (Madison, Wisconsin)
ABSTRACT The present invention discloses mass spectrometry (MS)-based methods and tagging reagents for qualitative and quantitative analysis of post-translational modified (PTM) proteins in biological and clinical samples. The present invention utilizes thiol-containing tagging reagents which are able to bind to or derivatize biomolecules, preferably post-translational modified (PTM) polypeptides such as citrullinated and homocitrullinated polypeptides. The tagging reagents are preferably biotin-derived tags able to react with a side chain of the modified polypeptides.
FILED Monday, December 14, 2020
APPL NO 17/121242
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6848 (20130101) Original (OR) Class
G01N 2440/18 (20130101)
G01N 2458/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111378 Rispoli et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Joseph V. Rispoli (West Lafayette, Indiana);  Xin Li (Saint Anthony, Minnesota)
ABSTRACT A method of operating a multi-coil magnetic resonance imaging system is disclosed which includes a controller performing a simulation using a predefined tissue model, determining output values of a variable of interest (VOI) associated with operation of two or more coils of an MRI system based on the simulation, comparing the simulated output values of the VOI to an a priori target values of the VOI, if the simulated output values of the VOI are outside of a predetermined envelope about the a priori target values of the VOI, then performing an optimization, wherein the optimization includes iteratively adjusting the circuit values until the simulated output values of the VOI are within the predetermined envelope about the a priori target values of the VOI thereby establishing VOI optimized values, and loading the established VOI optimized values and operating the magnetic resonance imaging system on the tissue to be imaged.
FILED Monday, July 03, 2023
APPL NO 18/217976
ART UNIT 3798 — Printing/Measuring and Testing
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/055 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/288 (20130101)
G01R 33/543 (20130101)
G01R 33/3415 (20130101)
G01R 33/5659 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112936 Jarrold et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S) THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
INVENTOR(S) Martin F. Jarrold (Bloomington, Indiana);  Aaron A. Todd (Bloomington, Indiana)
ABSTRACT A charge detection mass spectrometer includes an ion trap configured to receive and store ions therein and to selectively release stored ions therefrom, and an electrostatic linear ion trap (ELIT) spaced apart from the ion trap, the ELIT including first and second ion mirrors and a charge detection cylinder positioned therebetween, and means for selectively controlling the ion trap to release at least some of the stored ions therefrom to travel toward and into the ELIT, and for controlling the first and second ion mirrors in a manner which traps in the ELIT a single one of the ions traveling therein and causes the trapped ion to oscillate back and forth between the first and second ion mirrors each time passing through and inducing a corresponding charge on the charge detection cylinder.
FILED Tuesday, September 22, 2020
APPL NO 17/760501
ART UNIT 2881 — Optics
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/406 (20130101)
H01J 49/4245 (20130101) Original (OR) Class
H01J 49/4265 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 12109079 Reichenbach et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
APPLICANT(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
INVENTOR(S) Mark Reichenbach (Lincoln, Nebraska);  Shane Farritor (Lincoln, Nebraska)
ABSTRACT Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.
FILED Monday, October 09, 2023
APPL NO 18/482959
ART UNIT 3656 — Material and Article Handling
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/00149 (20130101)
A61B 17/0206 (20130101)
A61B 34/30 (20160201)
A61B 34/73 (20160201)
A61B 90/50 (20160201) Original (OR) Class
A61B 2017/00477 (20130101)
A61B 2034/302 (20160201)
A61B 2218/002 (20130101)
A61B 2218/007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109131 Sanders et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Joan E. Sanders (Seattle, Washington);  Joseph L. Garbini (Seattle, Washington);  Jake McLean (Seattle, Washington);  Jacob Brzostowski (Seattle, Washington);  Christian B. Redd (Seattle, Washington);  John Cagle (Seattle, Washington);  Samuel Bennett (Seattle, Washington);  Horace Wang (Seattle, Washington);  Ethan Weathersby (Seattle, Washington);  Andrew Vamos (Seattle, Washington)
ABSTRACT The disclosure provides example apparatus and methods for automatically adjusting a socket size of a prosthesis. The apparatus includes (a) the prosthesis having a socket configured to receive a limb, (b) a first opening in a socket wall, (c) a first panel aligned with the first opening, (d) a first actuator coupled to the first panel and to the prosthesis, the first actuator is configured to advance and retract the first panel, (e) a first sensor coupled to the socket wall and configured to obtain limb-to-socket gap data, and (f) a processor coupled to the first actuator and the first sensor, wherein the processor is configured (i) to receive the limb-to-socket gap data, (ii) to determine a socket-size adjustment based on the limb-to-socket gap data and a predetermined socket-fit value, (iii) to generate and (iv) to send a command with the socket-size adjustment to the first actuator.
FILED Friday, May 01, 2020
APPL NO 16/865088
ART UNIT 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/70 (20130101)
A61F 2/76 (20130101) Original (OR) Class
A61F 2/80 (20130101)
A61F 2002/701 (20130101)
A61F 2002/704 (20130101)
A61F 2002/762 (20130101)
A61F 2002/5027 (20130101)
A61F 2002/6863 (20130101)
A61F 2002/7818 (20130101)
A61F 2002/7875 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109535 Sibener et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
INVENTOR(S) Steven J. Sibener (Chicago, Illinois);  Kevin D. Gibson (Blue Island, Illinois)
ABSTRACT Methods for enriching, separating, or enriching and separating isotopes and isotopologues, as well as other chemical species, contained in a supersonic beam are provided. In the methods, a supersonic beam having different isotopes, isotopologues, or other chemical species entrained therein and a beam comprising a matrix material converge on a surface. As the matrix material forms a solid matrix on the surface, heavier isotopes, isotopologues, and/or other chemical species become preferentially embedded in the matrix, while lighter isotopes, isotopologues, and/or other chemical species are preferentially scattered from the surface.
FILED Wednesday, November 03, 2021
APPL NO 17/453357
ART UNIT 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Separation
B01D 59/18 (20130101)
B01D 59/26 (20130101) Original (OR) Class
B01D 59/34 (20130101)

Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes
G21K 1/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109558 Halas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for STEM Education (EDU)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) William Marsh Rice University (Houston, Texas)
ASSIGNEE(S) William Marsh Rice University (Houston, Texas)
INVENTOR(S) Nancy Jean Halas (Houston, Texas);  Peter Nordlander (Houston, Texas);  Hossein Robatjazi (Houston, Texas);  Dayne Francis Swearer (Houston, Texas);  Chao Zhang (Houston, Texas);  Hangqi Zhao (Houston, Texas);  Linan Zhou (Houston, Texas)
ABSTRACT A multicomponent photocatalyst includes a reactive component optically, electronically, or thermally coupled to a plasmonic material. A method of performing a catalytic reaction includes loading a multicomponent photocatalyst including a reactive component optically, electronically, or thermally coupled to a plasmonic material into a reaction chamber; introducing molecular reactants into the reaction chamber; and illuminating the reaction chamber with a light source.
FILED Wednesday, August 12, 2020
APPL NO 16/991555
ART UNIT 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/123 (20130101)
B01J 19/127 (20130101)
B01J 21/02 (20130101)
B01J 21/04 (20130101)
B01J 21/10 (20130101)
B01J 23/002 (20130101)
B01J 23/38 (20130101)
B01J 23/44 (20130101)
B01J 23/50 (20130101)
B01J 23/52 (20130101)
B01J 23/58 (20130101)
B01J 23/72 (20130101)
B01J 23/78 (20130101)
B01J 23/8926 (20130101)
B01J 23/8946 (20130101)
B01J 27/04 (20130101)
B01J 27/14 (20130101)
B01J 27/20 (20130101)
B01J 27/22 (20130101)
B01J 27/24 (20130101)
B01J 31/06 (20130101)
B01J 31/1691 (20130101)
B01J 35/19 (20240101)
B01J 35/23 (20240101)
B01J 35/30 (20240101)
B01J 35/33 (20240101)
B01J 35/39 (20240101) Original (OR) Class
B01J 35/50 (20240101)
B01J 35/393 (20240101)
B01J 35/397 (20240101)
B01J 35/651 (20240101)
B01J 37/03 (20130101)
B01J 37/08 (20130101)
B01J 37/031 (20130101)
B01J 37/035 (20130101)
B01J 37/0203 (20130101)
B01J 37/0225 (20130101)
B01J 37/344 (20130101)
B01J 2219/00635 (20130101)
B01J 2523/00 (20130101)
B01J 2523/00 (20130101)
B01J 2523/17 (20130101)
B01J 2523/22 (20130101)
B01J 2523/31 (20130101)
B01J 2523/821 (20130101)
B01J 2540/66 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 3/40 (20130101)
C01B 3/047 (20130101)
C01B 4/00 (20130101)
C01B 5/00 (20130101)
C01B 21/02 (20130101)
C01B 32/40 (20170801)
C01B 2203/0238 (20130101)
C01B 2203/1076 (20130101)
C01B 2203/1082 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110096 MacDonald et al.
FUNDED BY
Department of Defense (DOD)
APPLICANT(S) The Boeing Company (Chicago, Illinois)
ASSIGNEE(S) The Boeing Company (Arlington, Virginia)
INVENTOR(S) Elaine MacDonald (Wildwood, Missouri);  Jeremy Nicholas O'Hara (University City, Missouri);  Daniel Edward Driemeyer (St. Louis, Missouri);  Grant G. Gvozdich (Columbia, Illinois);  Justin L'Hote (St. Peters, Missouri);  Ali Yousefiani (Tustin, California);  Nicholas B. Segobiano (St. Louis, Missouri)
ABSTRACT An envelope portion of an airborne craft comprises a metallic outer wall and a metallic inner wall arranged interior to the outer wall. The outer and inner walls delimit an inter-wall volume configured to support a flow of coolant to cool the outer wall during atmospheric heating of the outer wall.
FILED Friday, February 11, 2022
APPL NO 17/650771
ART UNIT 3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Aeroplanes; Helicopters
B64C 1/38 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110137 Anderson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Michael Anderson (Colorado Springs, Colorado);  Grant Appel (O'Fallon, Illinois);  Nathaniel Bowen (Columbus, Mississippi);  Hugh Briggs (Colorado Springs, Colorado);  Spencer Flint (Seattle, Washington);  Seth Konig (Biloxi, Mississippi);  Erin Leslie (Oklahoma City, Oklahoma)
ABSTRACT A method of establishing a system for gathering surveillance data in a hostile environment. The method comprises the steps of providing a movable tractor for ground hauling a trailer, and providing a drone which can be operated independently from the tractor. The trailer has a floor pan for supporting a relay sensor dispensing mechanism and a platform above the floor pan, with a hole for dispensing relay sensors therethrough. The relay sensor dispensing mechanism has an elevator for holding a stockpile of relay sensors, and elevating the relay sensors through the hole. The method comprises disposing at least one relay sensor in the elevator, elevating the relay sensor to a pickup position at or above the platform and retrieving the relay sensor with a drone for subsequent deposition in the hostile environment. The relay sensor then gathers and transceives surveillance data for use and interpretation by an operator. Optional a conveyor chute may replenish the elevator when it is depleted of relay sensors.
FILED Friday, August 26, 2022
APPL NO 17/822481
ART UNIT 3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects
B60P 1/38 (20130101)

Unmanned aerial vehicles [UAV]; equipment therefor
B64U 10/00 (20230101) Original (OR) Class
B64U 2101/60 (20230101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110367 Wetzel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) CCDC Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S) The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) Eric D. Wetzel (Baltimore, Maryland);  Emil Jose Sandoz-Rosado (Baltimore, Maryland);  Todd David Beaudet (Aberdeen, Maryland);  Radhakrishnan Balu (Columbia, Maryland);  John Joseph La Scala (Wilmington, Delaware);  Dominika Nini Lastovickova (Aberdeen, Maryland)
ABSTRACT A family of new and novel molecules for mechanically superior two-dimensional (2D) polymers is described herein. By combining stiff carbon-containing cyclic polymer nodal units with more compliant linear polymer bridge units in an ordered, 2D repeating molecular structure it is possible to tailor the mechanical properties of 2D polymers and their assemblies to provide high stiffness, strength, and toughness. Furthermore, the inherent dimensionality of 2D polymers and their ability to be stacked into ordered and chemically interactive ensembles gives them inherent benefits in a variety of barrier and structural applications over current stiff and strong linear polymer technologies.
FILED Thursday, January 16, 2020
APPL NO 16/744293
ART UNIT 1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 63/00 (20130101)
C08G 63/065 (20130101)
C08G 63/78 (20130101)
C08G 63/127 (20130101)
C08G 63/133 (20130101)
C08G 69/32 (20130101)
C08G 73/18 (20130101)
C08G 73/22 (20130101)
C08G 73/028 (20130101)
C08G 73/1067 (20130101) Original (OR) Class
C08G 75/32 (20130101)

Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 5/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110376 Matis et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Bernard R. Matis (Alexandria, Virginia);  Nicholas T. Gangemi (Washington, District of Columbia);  Jeffrey W. Baldwin (Fairfax, Virginia);  Steven W. Liskey (Odenton, Maryland);  Aaron D. Edmunds (Alexandria, Virginia);  William B. Wilson (Pasadena, Maryland);  Douglas M. Photiadis (Alexandria, Virginia)
ABSTRACT An article having: an elastomeric jacket; a gel within the jacket; and a plurality of gas-filled, polymerically-encapsulated microbubbles suspended in the gel. The microbubbles have a Gaussian particle size distribution. The largest microbubble has a diameter at least 10 times the diameter of the smallest microbubble. The article may exhibit Anderson localization at at least one frequency of sound waves impacting the article.
FILED Tuesday, January 25, 2022
APPL NO 17/583697
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/075 (20130101)
C08J 9/236 (20130101) Original (OR) Class
C08J 2203/22 (20130101)
C08J 2205/02 (20130101)
C08J 2300/26 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/032 (20130101)
G01N 29/036 (20130101)
G01N 2291/02433 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110532 Petillo et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Design-Zyme LLC (Lawrence, Kansas)
ASSIGNEE(S) DESIGN- ZYME LLC (Lawrence, Kansas)
INVENTOR(S) Peter Albert Petillo (Lawrence, Kansas);  Dwight O'Dell Deay, III (Lawrence, Kansas)
ABSTRACT The present invention is broadly concerned with new in vitro glycosylation methods that provide rational approaches for producing glycosylated proteins, and the use of glycosylated proteins. In more detail, the present invention comprises methods of glycosylating a starting protein having an amino sidechain with a nucleophilic moiety, comprising the step of reacting the protein with a carbohydrate having an oxazoline moiety on the reducing end thereof, to covalently bond the amino sidechain of the starting protein with the oxazoline moiety, wherein the glycosylated protein substantially retains the structure and function of the starting protein. Target proteins include oxidase, oxidoreductase and dehydrogenase enzymes. The glycosylated proteins advantageously have molecular weights of at least about 7500 Daltons. In a further embodiment, the present invention concerns the use of glycosylated proteins, fabricated by the methods disclosed herein, in the assembly of amperometric biosensors.
FILED Thursday, February 16, 2023
APPL NO 18/170045
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Peptides
C07K 1/006 (20130101)
C07K 1/1077 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0004 (20130101)
C12N 9/0006 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/005 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110676 Littlefield et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) Woods Hole Oceanographic Institution (Woods Hole, Massachusetts)
ASSIGNEE(S) WOODS HOLE OCEANOGRAPHIC INSTITUTION (Woods Hole, Massachusetts)
INVENTOR(S) Robin Littlefield (Falmouth, Massachusetts);  Jeffrey Kaeli (Woods Hole, Massachusetts)
ABSTRACT A stowable generator device including a housing defining at least one storage chamber having an opening. A closure element is configured to selectively cover and uncover the opening. Support structure is disposed within the storage chamber in a collapsed position and is selectively extendable through the opening into an expanded position when the closure element is moved away from the opening. At least one energy generating unit is connected to the support structure. The support structure and the generating unit are configured to reversibly stow inside the housing in the collapsed position.
FILED Monday, May 02, 2022
APPL NO 17/734183
ART UNIT 3635 — Static Structures, Supports and Furniture
CURRENT CPC
Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages
B65D 85/68 (20130101)
B65D 88/121 (20130101)

General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings
E04B 1/344 (20130101) Original (OR) Class

Wind Motors
F03D 13/20 (20160501)

Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G
F05B 2240/91 (20130101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 10/12 (20141201)
H02S 30/20 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111148 Ferro et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Evendale, Ohio)
INVENTOR(S) Andrew Frank Ferro (West Chester, Ohio);  Peter Coomes (Middletown, Ohio)
ABSTRACT A system for imaging a component defining a negative space is provided comprising a component imaging assembly, a bolus insert, and an imaging device. The bolus insert is positionable in the component's negative space when the component is positioned within an imaging device imaging field to produce a component image. A method is provided comprising positioning a bolus insert within a component's negative space and scanning the component having the bolus insert to create an image of the component. A component imaging assembly is provided comprising a component including a first portion having a first thickness that is greater than a second thickness of a second portion; and a bolus insert positioned adjacent the second portion that has a bolus thickness substantially similar to a difference between the first and second thicknesses. The bolus insert has a bolus material density within fifteen percent (15%) of a component material density.
FILED Friday, May 21, 2021
APPL NO 17/326778
ART UNIT 2884 — Optics
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 15/04 (20130101) Original (OR) Class

Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 13/00 (20130101)
G01M 15/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111278 Hauser et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Aberdeen Proving Ground (APG)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) The Board of Trustees of the University of Alabama (Tuscaloosa, Alabama);  The U.S. Army, Edgewood Chemical and Biological Center (Aberdeen Proving Ground, Maryland)
ASSIGNEE(S) The Board of Trustees of the University of Alabama (Tuscaloosa, Alabama);  The U.S. Army, Edgewood Chemical and Biological Center (Aberdeen Proving Ground, Maryland)
INVENTOR(S) Adam Hauser (Tuscaloosa, Alabama);  Jennifer Rose Soliz (Ellicott City, Maryland);  Smriti Ranjit (Tuscaloosa, Alabama)
ABSTRACT An apparatus for sensing a target analyte includes a sensing material of a baseline composition. The sensing material is in electrical communication with an alternating energy input across the sensing material at a first frequency. The sensing material is configured to be placed within an environment such that an exposed state is in communication with a concentration of a target analyte proximate the sensing material, and wherein the target analyte changes at least one compositional property of the baseline composition. An impedance detection device is connected to a sensing circuit and receives an output from the sensing material, the output exhibiting a respective impedance value of the sensing material corresponding to the input for the first frequency. The respective impedance value is dependent upon the concentration of the target analyte in the environment and the first frequency.
FILED Tuesday, April 30, 2019
APPL NO 16/398825
ART UNIT 1796 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/026 (20130101)
G01N 27/221 (20130101) Original (OR) Class
G01N 29/226 (20130101)
G01N 2027/222 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111289 Fincke et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Jonathan Randall Fincke (Lincoln, Massachusetts);  Brian W. Anthony (Cambridge, Massachusetts)
ABSTRACT Systems and methods are provided for imaging of soft and hard tissues with ultrasound. Such systems and methods can provide for non-contact and quantitative ultrasound images of bone and soft tissue. A method for imaging a biological body segment of soft and hard tissues includes setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set. The method further includes collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set and minimizing a difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. Regularizing travel-time and/or using full waveform tomographic techniques with level set methods enable recovery of cortical bone geometry.
FILED Wednesday, June 26, 2019
APPL NO 17/255410
ART UNIT 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0095 (20130101)
A61B 8/13 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/0672 (20130101) Original (OR) Class
G01N 29/2418 (20130101)
G01N 33/12 (20130101)
G01N 2291/02475 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111496 Puckett et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Honeywell International Inc. (Charlotte, North Carolina)
ASSIGNEE(S) Honeywell International Inc. (Charlotte, North Carolina)
INVENTOR(S) Matthew Wade Puckett (Phoenix, Arizona);  Chad Hoyt (Roseville, Minnesota);  Karl D. Nelson (Plymouth, Minnesota);  Jianfeng Wu (Tucson, Arizona)
ABSTRACT Techniques are provided for implementing a low insertion loss optical coupler utilizing a low confinement planar optical waveguide and two high confinement planar optical waveguides. The optical coupler efficiently couples an optical signal with a cross section greater than either high confinement planar optical waveguide.
FILED Friday, June 17, 2022
APPL NO 17/843485
ART UNIT 2874 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/124 (20130101)
G02B 6/125 (20130101) Original (OR) Class
G02B 6/1228 (20130101)
G02B 6/2821 (20130101)
G02B 2006/12107 (20130101)
G02B 2006/12147 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111511 Paranto et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S) Applied Research Associates, Inc. (Albuquerque, New Mexico)
INVENTOR(S) Joseph N. Paranto (Albuquerque, New Mexico);  Michael E. Meline (Albuquerque, New Mexico);  Devin M. J. Todd (Orlando, Florida);  Matthew Flint Kepler (Austin, Texas);  Martin William Slack (Edgewood, New Mexico)
ABSTRACT Configurations and compositions for frameworks supporting optics such as lenses are described that provide an invariant structure regardless of temperature swings, thereby maintaining alignment and focus. Frameworks may comprise tiered structures of materials having multiple distinct coefficients of thermal expansion. An optical framework includes a first framework portion coupled to a first lens and a second framework portion coupled to a second lens. The first framework portion and second framework portion comprise materials having a coefficient of thermal expansion such that expansion of the first framework portion in one direction is offset by expansion of the second framework portion in an opposite direction.
FILED Thursday, May 20, 2021
APPL NO 17/325982
ART UNIT 2872 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 7/008 (20130101)
G02B 7/021 (20130101)
G02B 7/028 (20130101) Original (OR) Class

Pictorial Communication, e.g Television
H04N 23/55 (20230101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111557 Winsor et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Beam Engineering for Advanced Measurements Co. (Orlando, Florida);  Defense Advanced Research Projects Agency (Arlington, Virginia)
ASSIGNEE(S) Beam Engineering for Advanced Measurements Co. (Orlando, Florida);  Defense Advanced Research Projects Agency (DARPA) (Arlington, Virginia)
INVENTOR(S) Robert Winsor (Hamilton, Virginia);  Paul Calhoun (Washington, District of Columbia);  David Roberts (Apopka, Florida);  Nelson Tabirian (Winter Park, Florida)
ABSTRACT Opto-mechanical assemblies, systems, devices and methods for pointing laser and other optical beams, and for directing the field of view of sensors are disclosed. The assemblies consist of thin rotating optical elements of a type that diffracts the optical beam over a wide field of regard in two dimensions, and the angle of incidence of the optical beam or line of sight impinging on the optical elements are dynamically controlled maximizing the diffraction efficiency of the optical elements.
FILED Monday, July 03, 2023
APPL NO 18/217853
ART UNIT 2871 — Optics
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/292 (20130101) Original (OR) Class

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112820 Alacchi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S) University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S) Aurelien Alacchi (Salt Lake City, Utah);  Pierre-Emmanuel Gaillardon (Salt Lake City, Utah)
ABSTRACT Electronic devices and methods for single event effect mitigation are described. The device can include a processor, a memory cell, and an integrated particle sensor. The memory cell can comprise a substrate, a deep well coupled to the substrate, and a ground-coupled well coupled to the deep well. The integrated particle sensor can be coupled between the substrate and the deep well, and the ground-coupled well and the deep well. The integrated particle sensor can be operable to detect an ionizing particle generating the single event effect. The electronic device can be a field-programmable gate array. The method can include detecting an ionizing particle generating a single event effect at a memory cell of the electronic device, switching from the memory cell to a redundant memory cell associated with the memory cell when the single event effect is detected, and reconfiguring the memory cell based on the redundant memory cell.
FILED Wednesday, December 01, 2021
APPL NO 17/539923
ART UNIT 2824 — Semiconductors/Memory
CURRENT CPC
Static Stores
G11C 7/06 (20130101)
G11C 7/1057 (20130101)
G11C 7/1084 (20130101)
G11C 29/38 (20130101)
G11C 29/789 (20130101)
G11C 29/4401 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112982 Mohseni et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Hooman Mohseni (Wilmette, Illinois);  Simone Bianconi (Evanston, Illinois)
ABSTRACT Methods for creating a conductive feature in a dielectric material are provided. In an embodiment, such a method comprises irradiating a region of a dielectric material having a resistivity of at least 108 W cm with a focused ion beam, the irradiated region corresponding to a conductive feature embedded in the dielectric material, the conductive feature having a conductivity greater than that of the dielectric material; and forming one or more contact pads of a conductive material in electrical communication with the conductive feature, the one or more contact pads configured to apply a voltage across the conductive feature using a voltage source.
FILED Thursday, November 07, 2019
APPL NO 17/293276
ART UNIT 2896 — Optics
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/42 (20130101)
H01L 21/76823 (20130101) Original (OR) Class
H01L 21/76825 (20130101)
H01L 21/76843 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113070 Baars et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Technologies for Mixed-mode Ultra Scaled Integrated Circuits (T-MUSIC)
APPLICANT(S) GlobalFoundries U.S. Inc. (Malta, New York)
ASSIGNEE(S) GlobalFoundries U.S. Inc. (Malta, New York)
INVENTOR(S) Peter Baars (Dresden, Germany);  Viorel Ontalus (Unionville, Connecticut);  Ketankumar H. Tailor (Dresden, Germany);  Michael Zier (Dresden, Germany);  Crystal R. Kenney (Waterford, New York);  Judson Holt (Ballston Lake, New York)
ABSTRACT Structures including a vertical heterojunction bipolar transistor and methods of forming a structure including a vertical heterojunction bipolar transistor. The structure comprises a semiconductor substrate including a trench, a first semiconductor layer including a portion adjacent to the trench, a dielectric layer between the first semiconductor layer and the semiconductor substrate, and a second semiconductor layer in the trench. The dielectric layer has an interface with the first semiconductor layer, and the second semiconductor layer includes a portion that is recessed relative to the interface. The structure further comprises a vertical heterojunction bipolar transistor including a collector in the portion of the second semiconductor layer.
FILED Thursday, June 02, 2022
APPL NO 17/830830
ART UNIT 2897 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/84 (20130101)
H01L 27/1207 (20130101) Original (OR) Class
H01L 29/66242 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113146 Merrett
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Joseph Neil Merrett (Decherd, Tennessee)
ABSTRACT A semiconductor structure configured to implement an optically controlled field effect transistor (FET). In one embodiment, a normally-off, optically controlled FET is realized as a semiconductor structure comprising various regions configured to implement a voltage controlled, normally on, high voltage FET region having integrated thereon a photoconductive region configured to reduce a gate-to-source voltage of the FET in response to light incident upon the photoconductive region so as to turn the FET on.
FILED Friday, September 09, 2022
APPL NO 17/931067
ART UNIT 2812 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/1136 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113281 Bastin
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Nantenna LLC (Melbourne, Florida)
ASSIGNEE(S) Nantenna LLC (Melbourne, Florida)
INVENTOR(S) Gary L. Bastin (Palm Bay, Florida)
ABSTRACT The teachings of the present application generally for an ultra-high frequency (UHF) antenna assembly which provides for a smaller package size with the same or better efficiency as a much larger antenna, particularly between 100 MHz to 500 MHZ. Particularly, through the combination of components and structures for implementing frequency selective surfaces (FSS) and high impedance structures (HIS) in combination with an anisotropic magneto-dielectric material, the present teachings provide for the use of both lower and higher frequency techniques through the operational frequency band and miniaturization, accurately improving the performance of UHF satellite communication antennas. Specifically improving performance in narrowband, with increases in efficiency, bandwidth, and lowered elevation angle radiation characteristics.
FILED Monday, August 08, 2022
APPL NO 18/681417
ART UNIT 2845 — Electrical Circuits and Systems
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 9/285 (20130101)
H01Q 15/006 (20130101)
H01Q 19/108 (20130101) Original (OR) Class
H01Q 19/185 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12114403 Skinner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) Mainstream Engineering Corporation (Rockledge, Florida)
ASSIGNEE(S) Mainstream Engineering Corporation (Rockledge, Florida)
INVENTOR(S) Anna P. Skinner (Rockledge, Florida);  Kayla S. O'Neill (Madison, Wisconsin);  Rachna C. Igwe (Melbourne, Florida);  Philip Cox (Cocoa Beach, Florida);  Justin J. Hill (Cape Canaveral, Florida)
ABSTRACT The present invention is an apparatus for curing composites out-of-autoclave and out-of-oven. The apparatus is a multilayered composite tool for shaping and curing composites. It also contains a sealant layer and composite resistive heating element on the tool's surface. This heating element provides heat to the composites during cure while binding it to the other layers, eliminating the need for external heat from autoclave and oven sources. A ceramic layer is applied to the top surface of the resistive heater for electrical insulation, heater protection and to provide a smooth surface for finish for the composite components being processed with the invention. A method for using the invention is also described. Finally, one embodiment of the invention is presented where a negative composite tool is created to apply additional pressure to the composite component during curing. This additional pressure enables the current invention to more closely mimic autoclave composite processing.
FILED Thursday, December 14, 2023
APPL NO 18/539816
ART UNIT 3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 33/02 (20130101)
B29C 33/3807 (20130101)

Electric Heating; Electric Lighting Not Otherwise Provided for
H05B 3/34 (20130101)
H05B 3/145 (20130101) Original (OR) Class
H05B 2203/005 (20130101)
H05B 2203/011 (20130101)
H05B 2203/013 (20130101)
H05B 2214/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12114569 Feigelson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Boris N. Feigelson (Springfield, Virginia);  Kevin P. Anderson (Arlington, Virginia);  Benjamin L Greenberg (Alexandria, Virginia);  James A. Wollmershauser (Alexandria, Virginia);  Alan G. Jacobs (Rockville, Maryland)
ABSTRACT Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material. In other embodiments, the TE nanocomposite material can be a nanocomposite thermoelectric material having one network of p-type or n-type semiconductor domains and a low thermal conductivity semiconductor or dielectric network or domains separating the p-type or n-type domains that provides efficient phonon scattering to reduce thermal conductivity while maintaining the electrical properties of the p-type or n-type semiconductor.
FILED Friday, December 02, 2022
APPL NO 18/061012
ART UNIT 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/60 (20130101)
C01P 2002/88 (20130101)
C01P 2004/64 (20130101)
C01P 2006/32 (20130101)
C01P 2006/40 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 35/64 (20130101)
C04B 35/117 (20130101)
C04B 35/488 (20130101)
C04B 35/6261 (20130101)
C04B 35/62813 (20130101)
C04B 35/62823 (20130101)
C04B 35/62884 (20130101)
C04B 2235/428 (20130101)
C04B 2235/614 (20130101)
C04B 2235/781 (20130101)
C04B 2235/785 (20130101)
C04B 2235/3217 (20130101)
C04B 2235/3244 (20130101)
C04B 2235/5445 (20130101)
C04B 2235/5454 (20130101)
C04B 2235/9607 (20130101)

Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black;
C09C 1/28 (20130101)
C09C 3/006 (20130101)
C09C 3/041 (20130101)
C09C 3/043 (20130101)
C09C 3/063 (20130101)

Electric solid-state devices not otherwise provided for
H10N 10/01 (20230201) Original (OR) Class
H10N 10/852 (20230201)
H10N 10/857 (20230201)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 12109549 Luz Minguez et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) Research Triangle Institute (Research Triangle Park, North Carolina)
ASSIGNEE(S) Research Triangle Institute (Research Triangle Park, North Carolina)
INVENTOR(S) Ignacio Luz Minguez (Durham, North Carolina);  Mustapha Soukri (Cary, North Carolina);  Marty Lail (Raleigh, North Carolina);  Lora Goon Toy (Morrisville, North Carolina)
ABSTRACT A method for making a metal organic framework suspension is described herein. The method includes providing a hybrid material comprising a nano-crystalline metal organic framework comprising micropores and a mesoporous polymeric material comprising mesopores, wherein the nano-crystalline metal organic framework is homogeneously dispersed and substantially present only within the mesopores or void spaces of the mesoporous polymeric material; and wherein the hybrid material has a weight percentage of the metal organic framework in the range of 5-50% relative to the total weight of the hybrid material. The method includes contacting the hybrid material with a solvent in which the mesoporous polymeric material is soluble, thereby forming a polymeric solution in which the nano-crystalline metal organic framework is substantially homogeneously dispersed and suspended.
FILED Friday, May 17, 2019
APPL NO 17/054590
ART UNIT 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Separation
B01D 53/02 (20130101)
B01D 53/228 (20130101)
B01D 2253/204 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/226 (20130101) Original (OR) Class
B01J 20/28026 (20130101)
B01J 20/28033 (20130101)
B01J 20/28059 (20130101)
B01J 20/28061 (20130101)
B01J 20/28064 (20130101)
B01J 20/28066 (20130101)
B01J 20/28083 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109593 Garcia, Jr. et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Sortera Alloys, Inc. (Fort Wayne, Indiana)
ASSIGNEE(S) SORTERA TECHNOLOGIES, INC. (Markle, Indiana)
INVENTOR(S) Manuel Gerardo Garcia, Jr. (Fort Wayne, Indiana);  Nalin Kumar (Fort Worth, Texas);  Casey Lee Hughlett (Fort Wayne, Indiana)
ABSTRACT A material handling system sorts materials utilizing a vision system of multiple vision devices configured with single board computers that each implement an artificial intelligence system in order to identify or classify materials, which are then sorted into separate groups based on such an identification or classification by sorting devices that are each coupled to one of the vision devices.
FILED Monday, October 24, 2022
APPL NO 17/972541
ART UNIT 3653 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Separating Solids From Solids by Sieving, Screening, Sifting or by Using Gas Currents; Separating by Other Dry Methods Applicable to Bulk Material, e.g Loose Articles Fit to be Handled Like Bulk Material
B07B 13/003 (20130101) Original (OR) Class
B07B 13/18 (20130101)

Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking
B07C 5/342 (20130101)

Electric Digital Data Processing
G06F 18/2413 (20230101)

Image Data Processing or Generation, in General
G06T 7/0006 (20130101)
G06T 2207/30136 (20130101)
G06T 2207/30141 (20130101)

Image or Video Recognition or Understanding
G06V 10/46 (20220101)
G06V 2201/06 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109613 Luo
FUNDED BY
Department of Energy (DOE)
Office of Environmental Management (DOE-EM)
Savannah River National Laboratory (SRNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Savannah River Nuclear Solutions, LLC (SRNS) at Aiken, SC
APPLICANT(S) BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina)
ASSIGNEE(S) Battelle Savannah River Alliance, LLC (Aiken, South Carolina)
INVENTOR(S) Yuefeng Luo (North Augusta, South Carolina)
ABSTRACT Additive manufacturing systems and methods are provided. An additive manufacturing system includes a build volume; a powder disposed in the build volume, the powder occupying at least a portion of the build volume and having an outer boundary; a beam generator configured to generate a beam to irradiate the powder; and a ram defining a passthrough configured to transmit the beam to an irradiation location disposed within the outer boundary of the powder.
FILED Thursday, November 04, 2021
APPL NO 17/518665
ART UNIT 1735 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 10/28 (20210101) Original (OR) Class
B22F 12/37 (20210101)
B22F 12/41 (20210101)
B22F 12/67 (20210101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110278 Jorgensen et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
NIH Office of the Director (NIHOD)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) William L. Jorgensen (Deep River, Connecticut);  Joseph Schlessinger (Woodbridge, Connecticut)
ABSTRACT The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I.
FILED Wednesday, October 13, 2021
APPL NO 17/500622
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4196 (20130101)
A61K 31/4245 (20130101)
A61K 31/4439 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 249/14 (20130101) Original (OR) Class
C07D 401/12 (20130101)
C07D 405/12 (20130101)
C07D 413/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110314 Lyman et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S) Mathew Gerald Lyman (Brentwood, California);  Deon S. Anex (Livermore, California);  Bonnee Rubinfeld (Danville, California)
ABSTRACT Described are methods, compositions, and devices for a concatemeric protein standard that behaves as a protein but transforms into single peptides upon digestion, which is optimized to function as a non-obtrusive process control for mass spectrometry analysis.
FILED Wednesday, September 28, 2022
APPL NO 17/955214
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Peptides
C07K 14/245 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6848 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110573 Allanore et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Massachusetts Institute of Technology (MIT) (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Antoine Allanore (Brentwood, New Hampshire);  Caspar R. Stinn (Medford, Massachusetts)
ABSTRACT In accordance with one embodiment, a method comprises dissolving a sulfide of a first metal in a solvent comprising molten aluminum; aluminothermically reduce at least a portion of the sulfide through reactive vacuum distillation to form gaseous aluminum sulfide distillate and elemental first metal that remains in the molten aluminum; and at least one of (e.g., one, two, or all three of) (a) reacting the aluminum sulfide distillate with at least one material in the molten aluminum; (b) reacting the aluminum sulfide distillate with at least one material outside of the molten aluminum; or (c) condensing the gaseous aluminum sulfide distillate.
FILED Friday, October 27, 2023
APPL NO 18/384722
ART UNIT 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Production and Refining of Metals; Pretreatment of Raw Materials
C22B 5/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111235 Regier et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing and Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Bernard K. Regier (Livermore, California);  Alex Cruz (Raymore, Missouri);  Benjamin Sorensen (Olathe, Kansas)
ABSTRACT A test fixture for vibration testing is disclosed. The test fixture may include an edge with a mounting slot for receiving a fastener to couple the test fixture to a supporting structure. A separating slot may extend through the test fixture proximal to the mounting slot. When the test fixture is coupled to the supporting structure via the mounting slot, the remainder of the test fixture may be unsupported, thereby cantilevering the test fixture. Cantilevering the test fixture, along with the flexibility provided by the separating slot, may enable the natural frequency of the test fixture to be controlled, allowing for additional vibrational frequencies to be measured and improving the signal-to-noise ratio. The length of the separating slot may be adjustable to adjust the frequency response of the test fixture. A coupling mass may also be attached to the test fixture to adjust the frequency response.
FILED Thursday, December 28, 2023
APPL NO 18/399635
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 7/027 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111237 Montgomery et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Rosemary A. Montgomery (Oak Ridge, Tennessee);  Meng-Dawn Cheng (Oak Ridge, Tennessee);  Yadukrishnan Sasikumar (Oak Ridge, Tennessee);  Bruce B. Bevard (Oak Ridge, Tennessee)
ABSTRACT A system for sampling aerosols, for purpose of predictive analyses, from fractured test specimens is provided. The system includes a test enclosure, a load apparatus, and an aerosol sampling pack in fluid communication with the test enclosure. The test enclosure is sized to partially or completely receive the test specimen therein, and the load apparatus is configured to impart a mechanical load (e.g., tension, bending, torsion, shear forces, or compression) on the test specimen. The aerosol sampling pack receives solid aerosols that are generated upon fracture of the test specimen.
FILED Wednesday, September 08, 2021
APPL NO 17/469419
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/2202 (20130101) Original (OR) Class
G01N 1/2211 (20130101)
G01N 2001/2223 (20130101)
G01N 2203/0019 (20130101)
G01N 2203/0021 (20130101)
G01N 2203/0023 (20130101)
G01N 2203/0025 (20130101)

Nuclear Reactors
G21C 17/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111241 Hering et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
National Institute for Occupational Safety and Health (NIOSH)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) Aerosol Dynamics Inc. (Berkeley, California)
ASSIGNEE(S) Aerosol Dynamics Inc. (Berkeley, California)
INVENTOR(S) Susanne Vera Hering (Berkeley, California);  Gregory Stephen Lewis (Berkeley, California);  Steven Russel Spielman (Oakland, California)
ABSTRACT A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber connected to an optical detector and an outlet by pumping at the outlet. The method further includes passing air through the chamber and optical detector in a steady flow, and subsequently closing the inlet while continuing the pumping to expand the air sample and exhaust a portion of the air sample through the optical detector. The walls of the particle chamber are wetted with a fluid such as water, and one portion of the wall is warmer than the other portions such that there is some condensational growth prior to the expansion, and yet more condensational growth during the expansion. The cycles are repeated by continuously repeating the introducing, passing and closing.
FILED Wednesday, January 05, 2022
APPL NO 17/568940
ART UNIT 2877 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/06 (20130101) Original (OR) Class
G01N 15/075 (20240101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111330 Senderos et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) The Boeing Company (Chicago, Illinois)
ASSIGNEE(S) The Boeing Company (Arlington, Virginia)
INVENTOR(S) Bruno Zamorano Senderos (Huntsville, Alabama);  Ali Yousefiani (Tustin, California);  Austin E. Mann (Chesterfield, Missouri);  Michael F. Stoia (Rancho Santa Margarita, California)
ABSTRACT A material compatibility test design system and method, allowing for the testing of characteristics of behavior of materials in extreme environments, the method including concurrently exposing a test specimen to a first environment and a second environment, the test specimen having an outside surface and an inside surface, the inside surface defining an internal volume, includes exposing the outside surface of the test specimen to the first environment for a predetermined period of time, the first environment comprising a first temperature, a first pressure and a first composition. The method further includes exposing the inside surface of the test specimen to the second environment for a second predetermined period of time, the second environment comprising a second temperature, a second pressure and a second composition.
FILED Wednesday, February 16, 2022
APPL NO 17/673085
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for
G01D 21/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 37/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111342 Owens et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Israel Owens (Albuquerque, New Mexico);  Andrew Charles Biller (Albuquerque, New Mexico)
ABSTRACT The present invention is directed to an electro-optical sensor for high intensity electric field measurement. The electro-optical sensor was used to measure a strong 118 MV/m narrow pulse width (˜33 ns) electric field in the magnetically insulated transmission line (MITL) of a pulsed power accelerator. Accurately measuring these high fields using conventional pulsed power diagnostics is difficult due to the strength of interfering particles and fields. The electro-optical sensor uses a free space laser beam with a dielectric crystal sensor that is highly immune to electromagnetic interference and does not require an external calibration.
FILED Tuesday, January 10, 2023
APPL NO 18/095153
ART UNIT 2858 — Printing/Measuring and Testing
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 29/0885 (20130101) Original (OR) Class

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/0136 (20130101)
G02F 1/0311 (20130101)
G02F 2201/58 (20130101)
G02F 2202/20 (20130101)
G02F 2202/36 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111758 Brewer et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S) Micron Technology, Inc. (Boise, Idaho)
INVENTOR(S) Tony M. Brewer (Plano, Texas);  Dean E. Walker (Allen, Texas)
ABSTRACT System and techniques for synchronized request handling at a memory device are described herein. A request is received at the memory device. Here, the request indicates a memory address corresponding to a set of cache lines and a single cache line in the set of cache lines. The memory device maintains a deferred list for the set of cache lines and a set of lists with each member of the set of lists corresponding to one cache line in the set of cache lines. The memory device tests the deferred list to determine that the deferred list is not empty and places the request in the deferred list.
FILED Tuesday, August 30, 2022
APPL NO 17/899197
ART UNIT 2139 — Memory Access and Control
CURRENT CPC
Electric Digital Data Processing
G06F 12/0238 (20130101) Original (OR) Class
G06F 12/0833 (20130101)
G06F 12/0893 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111767 Mashimo et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S) Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S) Susumu Mashimo (Boxborough, Massachusetts);  John Kalamatianos (Boxborough, Massachusetts)
ABSTRACT A method includes recording a first set of consecutive memory access deltas, where each of the consecutive memory access deltas represents a difference between two memory addresses accessed by an application, updating values in a prefetch training table based on the first set of memory access deltas, and predicting one or more memory addresses for prefetching responsive to a second set of consecutive memory access deltas and based on values in the prefetch training table.
FILED Wednesday, April 19, 2023
APPL NO 18/302968
ART UNIT 2139 — Memory Access and Control
CURRENT CPC
Electric Digital Data Processing
G06F 9/30036 (20130101)
G06F 9/30047 (20130101)
G06F 9/30101 (20130101)
G06F 12/0862 (20130101) Original (OR) Class
G06F 12/0877 (20130101)
G06F 18/214 (20230101)
G06F 2212/6024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111770 Brewer et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S) Micron Technology, Inc. (Boise, Idaho)
INVENTOR(S) Tony M. Brewer (Plano, Texas);  Dean E. Walker (Allen, Texas)
ABSTRACT System and techniques for silent cache line eviction are described herein. A memory device receives a memory operation from a host. The memory operation establishes data and metadata in a cache line of the memory device upon receipt. The metadata is stored in a memory element that corresponds to the cache line. Later, an eviction trigger to evict the cache line is identified. Then, in response to the eviction trigger, current metadata of the cache line is compared with the metadata in the memory element to determine whether the metadata has changed. the cache line can be evicted without writing to backing memory in response to the metadata being unchanged.
FILED Tuesday, August 30, 2022
APPL NO 17/823408
ART UNIT 2138 — Memory Access and Control
CURRENT CPC
Electric Digital Data Processing
G06F 9/3816 (20130101)
G06F 12/0891 (20130101) Original (OR) Class
G06F 2212/7209 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111821 Razeghi-Jahromi et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) ABB Schweiz AG (Baden, Switzerland)
ASSIGNEE(S) ABB Schweiz AG (Baden, Switzerland)
INVENTOR(S) Mohammad Razeghi-Jahromi (Cary, North Carolina);  David Lee Coats (Apex, North Carolina);  James D. Stoupis (Raleigh, North Carolina)
ABSTRACT A method for recovering missing phase measurement unit (PMU) measurements from a plurality of PMUs is provided. The method comprises: receiving a plurality of obtained PMU measurements from the plurality of PMUs; populating a PMU dataset based on the plurality of obtained PMU measurements; determining a plurality of missing entries within the PMU dataset, wherein each of the plurality of missing entries indicates a missing PMU measurement within the PMU dataset at a particular time; determining a plurality of substitute entries for the plurality of missing entries based on an optimization algorithm that determines differences associated with a missing entry, of the plurality of missing entries, and a first set of PMU measurements, of the plurality of obtained PMU measurements, that are taken immediately prior to the missing entry; and inserting the plurality of substitute entries into the PMU dataset to generate a new PMU dataset.
FILED Thursday, July 22, 2021
APPL NO 17/382578
ART UNIT 2857 — Printing/Measuring and Testing
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 25/00 (20130101)

Electric Digital Data Processing
G06F 16/2379 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111924 Gu et al.
FUNDED BY
Department of Energy (DOE)
Office of Electricity (DOE-OE)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S) Georgia Tech Research Corporation (Atlanta, Georgia)
INVENTOR(S) Qinchen Gu (Atlanta, Georgia);  Abdul Raheem Beyah (Atlanta, Georgia)
ABSTRACT A system (100) and method for detecting a malicious programmable logic controller (PLC) code segment (110) in a PLC program corresponding to a specific type of PLC includes a binary parser (112) that parses the code segment (110) into a plurality of functional elements. A variable and function block mapper (114) maps the functional elements into a high-level data structure. A fuzzer (116) generates a behavioral model of the high-level data structure into an automaton (118). A classifier (120) predicts to which processes the automaton (118) corresponds. A detector (122) detects unsafe states in the automaton (118) and that generates an indication of a detected unsafe state.
FILED Saturday, January 16, 2021
APPL NO 17/789439
ART UNIT 2453 — Computer Networks
CURRENT CPC
Electric Digital Data Processing
G06F 21/554 (20130101) Original (OR) Class
G06F 2221/034 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112236 Eichenfield et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Matt Eichenfield (Albuquerque, New Mexico);  Daniel Beom Soo Soh (Pleasanton, California);  Eric Chatterjee (Sammamish, Washington);  Jeffrey Charles Taylor (Albuquerque, New Mexico)
ABSTRACT Various reconfigurable phononic devices, including phase shifters, mirrors, Mach Zehnder interferometers, memories, and transducers for use in both classical and quantum computing systems are disclosed. The individual phononic devices may be combined in various configurations to implement desired, more complex functionality. The phononic devices may be coupled together to implement the desired functionality using phononic waveguides. The phononic devices include one or more phase shifters that are operationally based on either hyperelasticity or a moving boundary effect.
FILED Thursday, October 21, 2021
APPL NO 17/506749
ART UNIT 2874 — Optics
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 10/00 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/11 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class

Electric solid-state devices not otherwise provided for
H10N 30/20 (20230201)
H10N 60/80 (20230201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113163 Dharmasena et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S) GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S) Ruchira Dharmasena (Shelby Township, Michigan);  Shuru Chen (Troy, Michigan);  Fang Dai (Troy, Michigan);  Mei Cai (Bloomfield Hills, Michigan);  Sanaz Ketabi (Holt, Michigan)
ABSTRACT A system for coating a separator for a battery includes a separator feed and collection assembly configured to dispense the separator, a coating distribution device configured to flow a coating material toward the separator, and an electric field generator configured to generate an electric field in a gap between the coating distribution device and the separator.
FILED Wednesday, October 20, 2021
APPL NO 17/506446
ART UNIT 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0404 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 50/431 (20210101)
H01M 50/446 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113477 Ziegler et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) TelemeTrak, Inc. (Oakland, California)
ASSIGNEE(S) TelemeTrak, Inc. (Oakland, California)
INVENTOR(S) Frederick Steinway Ziegler (San Francisco, California);  Bjorn-Erik Eklund (San Francisco, California)
ABSTRACT The devices, systems, and methods described herein are directed to buffering the electrical energy output from a PV array before storing the electrical energy in a battery storage system of the PV system. In some examples, a buffering module receives electrical energy from one or more PV cells at a first level that exceeds a threshold charging rate of a battery storage system. The buffering module temporarily stores the electrical energy before outputting the electrical energy to the battery storage system at a second level that is at or below the threshold charging rate of the battery storage system.
FILED Tuesday, February 21, 2023
APPL NO 18/112287
ART UNIT 2836 — Electrical Circuits and Systems
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/35 (20130101)
H02J 7/345 (20130101)
H02J 15/003 (20130101)
H02J 15/007 (20200101)
H02J 2207/50 (20200101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 40/38 (20141201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113526 Voss et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Lars F. Voss (Livermore, California);  Adam M. Conway (Livermore, California)
ABSTRACT A high-voltage switch is adapted for use as a medium-voltage direct current circuit breaker, which provides a low-cost, small-footprint device to mitigate system faults. In one example, a method for operating a wideband optical device includes illuminating the wide bandgap optical device with a light within a first range of wavelengths and a first average intensity, allowing a current to propagate therethrough without substantial absorption of the current, illuminating the wide bandgap optical device with light within the first range of wavelengths and a second average intensity that is lower than the first average intensity to allow a sustained current flow though the wide bandgap optical device, and illuminating the wide bandgap optical device with light within a second range of wavelengths to stop or substantially restrict propagation of the current through the wide gap material.
FILED Tuesday, July 12, 2022
APPL NO 17/812018
ART UNIT 2878 — Optics
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/09 (20130101)
H01L 31/0288 (20130101)
H01L 31/03042 (20130101)
H01L 31/03044 (20130101)
H01L 31/03125 (20130101)

Pulse Technique
H03K 17/78 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 12108998 Hasser et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) INTUITIVE SURGICAL OPERATIONS, INC. (Sunnyvale, California);  The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) Intuitive Surgical Operations, Inc. (Sunnyvale, California);  The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Christopher J. Hasser (Los Altos, California);  Russell H. Taylor (Severna Park, Maryland);  Joshua Leven (San Francisco, California);  Michael Choti (Lutherville, Maryland)
ABSTRACT A LUS robotic surgical system is trainable by a surgeon to automatically move a LUS probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2D ultrasound image slices captured by the LUS probe according to stored instructions are processable into a 3D ultrasound computer model of an anatomic structure, which may be displayed as a 3D or 2D overlay to a camera view or in a PIP as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. Virtual fixtures are definable so as to assist the surgeon in accurately guiding a tool to a target on the displayed ultrasound image.
FILED Monday, June 12, 2023
APPL NO 18/332891
ART UNIT 2672 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/3132 (20130101)
A61B 8/00 (20130101)
A61B 8/12 (20130101)
A61B 8/461 (20130101)
A61B 8/4218 (20130101)
A61B 8/4245 (20130101)
A61B 34/25 (20160201)
A61B 34/30 (20160201)
A61B 34/37 (20160201) Original (OR) Class
A61B 34/70 (20160201)
A61B 34/76 (20160201)
A61B 90/03 (20160201)
A61B 90/37 (20160201)
A61B 90/361 (20160201)
A61B 2017/00203 (20130101)
A61B 2034/107 (20160201)
A61B 2034/305 (20160201)
A61B 2090/364 (20160201)
A61B 2090/365 (20160201)
A61B 2090/378 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109010 Torstrick et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Huxley Medical, Inc. (Atlanta, Georgia)
ASSIGNEE(S) Huxley Medical, Inc. (Atlanta, Georgia)
INVENTOR(S) Brennan Torstrick (Atlanta, Georgia);  Mohsen Safaei Mohammadabadi (Smyrna, Georgia)
ABSTRACT The present disclosure relates to devices and processes that produce superior photoplethysmography (PPG) signals. In various embodiments, the present devices and processes leverage load backing, conformal contact, and strain isolation mechanisms to produce higher quality and amplitude PPG signals, and provide more repeatable results than previous devices and processes. In at least one embodiment, the devices discussed herein include a rigid support structure and elastic spacer for supporting a PPG sensor and various adhesive layers.
FILED Monday, October 17, 2022
APPL NO 18/047166
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/282 (20210101)
A61B 5/02416 (20130101) Original (OR) Class
A61B 5/6833 (20130101)
A61B 2562/164 (20130101)
A61B 2562/166 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109548 Ma et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of South Florida (Tampa, Florida)
ASSIGNEE(S) UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
INVENTOR(S) Shengqian Ma (Tampa, Florida);  Qi Sun (Tampa, Florida)
ABSTRACT A variety of superhyrdophobic porous materials are provided including a covalent organic framework having a plurality of perfluoroalkyl or perfluorheteroalkyl moieties covalently attached thereto. The materials can include a polymeric foam matrix made of a three-dimensional network of polymer fibers, and the covalent organic framework can be made encasing at least a portion of the polymer fibers. The covalent organic framework can be intertwined within the polymeric foam matrix such that the covalent organic framework encasing the portion of the polymer fibers is stable to mechanical compression of the polymeric foam matrix. Surfaces and other articles are provided including the superhyrdophobic porous materials are also provided, as are methods of making the superhyrdophobic porous materials, and methods of use for oil recovery among other things.
FILED Saturday, January 12, 2019
APPL NO 16/961152
ART UNIT 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/226 (20130101) Original (OR) Class
B01J 20/262 (20130101)
B01J 20/3212 (20130101)
B01J 20/3217 (20130101)
B01J 20/3278 (20130101)
B01J 20/3293 (20130101)
B01J 20/28009 (20130101)
B01J 20/28026 (20130101)
B01J 20/28045 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12109558 Halas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for STEM Education (EDU)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) William Marsh Rice University (Houston, Texas)
ASSIGNEE(S) William Marsh Rice University (Houston, Texas)
INVENTOR(S) Nancy Jean Halas (Houston, Texas);  Peter Nordlander (Houston, Texas);  Hossein Robatjazi (Houston, Texas);  Dayne Francis Swearer (Houston, Texas);  Chao Zhang (Houston, Texas);  Hangqi Zhao (Houston, Texas);  Linan Zhou (Houston, Texas)
ABSTRACT A multicomponent photocatalyst includes a reactive component optically, electronically, or thermally coupled to a plasmonic material. A method of performing a catalytic reaction includes loading a multicomponent photocatalyst including a reactive component optically, electronically, or thermally coupled to a plasmonic material into a reaction chamber; introducing molecular reactants into the reaction chamber; and illuminating the reaction chamber with a light source.
FILED Wednesday, August 12, 2020
APPL NO 16/991555
ART UNIT 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/123 (20130101)
B01J 19/127 (20130101)
B01J 21/02 (20130101)
B01J 21/04 (20130101)
B01J 21/10 (20130101)
B01J 23/002 (20130101)
B01J 23/38 (20130101)
B01J 23/44 (20130101)
B01J 23/50 (20130101)
B01J 23/52 (20130101)
B01J 23/58 (20130101)
B01J 23/72 (20130101)
B01J 23/78 (20130101)
B01J 23/8926 (20130101)
B01J 23/8946 (20130101)
B01J 27/04 (20130101)
B01J 27/14 (20130101)
B01J 27/20 (20130101)
B01J 27/22 (20130101)
B01J 27/24 (20130101)
B01J 31/06 (20130101)
B01J 31/1691 (20130101)
B01J 35/19 (20240101)
B01J 35/23 (20240101)
B01J 35/30 (20240101)
B01J 35/33 (20240101)
B01J 35/39 (20240101) Original (OR) Class
B01J 35/50 (20240101)
B01J 35/393 (20240101)
B01J 35/397 (20240101)
B01J 35/651 (20240101)
B01J 37/03 (20130101)
B01J 37/08 (20130101)
B01J 37/031 (20130101)
B01J 37/035 (20130101)
B01J 37/0203 (20130101)
B01J 37/0225 (20130101)
B01J 37/344 (20130101)
B01J 2219/00635 (20130101)
B01J 2523/00 (20130101)
B01J 2523/00 (20130101)
B01J 2523/17 (20130101)
B01J 2523/22 (20130101)
B01J 2523/31 (20130101)
B01J 2523/821 (20130101)
B01J 2540/66 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 3/40 (20130101)
C01B 3/047 (20130101)
C01B 4/00 (20130101)
C01B 5/00 (20130101)
C01B 21/02 (20130101)
C01B 32/40 (20170801)
C01B 2203/0238 (20130101)
C01B 2203/1076 (20130101)
C01B 2203/1082 (20130101)
C01B 2203/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110310 Chang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Technology Transfer (STTR)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ASSIGNEE(S) UTAH STATE UNIVERSITY (North Logan, Utah)
INVENTOR(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ABSTRACT The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of:
where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases.
FILED Monday, January 25, 2021
APPL NO 17/157752
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7036 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/23 (20130101) Original (OR) Class
C07H 15/234 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110320 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S) Samuel Lai (Carrboro, North Carolina);  M. Gregory Forest (Chapel Hill, North Carolina);  Christine Henry (Chapel Hill, North Carolina);  Timothy Wessler (Durham, North Carolina);  Alexander Chen (Glenville, New York);  Jennifer Schiller (Chapel Hill, North Carolina);  Jay Newby (Carrboro, North Carolina)
ABSTRACT The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.
FILED Friday, March 18, 2022
APPL NO 17/698645
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)

Peptides
C07K 16/44 (20130101)
C07K 16/087 (20130101)
C07K 16/1045 (20130101)
C07K 16/1235 (20130101) Original (OR) Class
C07K 2317/41 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/557 (20130101)
G01N 33/6854 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2333/16 (20130101)
G01N 2333/4725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110397 Seo et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Dong-Kyun Seo (Chandler, Arizona);  Kamil Kaloush (Scottsdale, Arizona);  Alireza Samieadel (Tempe, Arizona);  Elham Fini (Phoenix, Arizona);  Shaojiang Chen (Mesa, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Dong-Kyun Seo (Chandler, Arizona);  Kamil Kaloush (Scottsdale, Arizona);  Alireza Samieadel (Tempe, Arizona);  Elham Fini (Phoenix, Arizona);  Shaojiang Chen (Mesa, Arizona)
ABSTRACT A modified bitumen includes bitumen and a bitumen modifier. The bitumen modifier includes composite particles. The composite particles include aluminosilicate nanostructures defining nanopores and micropores and paraffin wax adhered to surfaces of the aluminosilicate nanostructures. Modifying bitumen includes combining bitumen and the bitumen modifier.
FILED Thursday, April 01, 2021
APPL NO 17/220549
ART UNIT 1763 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/34 (20130101)
C08K 2201/011 (20130101)

Compositions of Macromolecular Compounds
C08L 91/06 (20130101)
C08L 95/00 (20130101) Original (OR) Class
C08L 2555/50 (20130101)
C08L 2555/72 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12111898 Lee et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Ruby Lee (Princeton, New Jersey);  Guangyuan Hu (Princeton, New Jersey)
ABSTRACT Devices and methods for smartphone impostor detection using behavioral and environmental data are provided. Impostors are attackers who take control of an electronic device (e.g., a smartphone) and gain access to confidential and private information of a legitimate user. Embodiments described herein propose a defense-in-depth mechanism to detect impostors quickly with simple deep learning algorithms, which can achieve better detection accuracy than previous works. Embodiments then consider protecting the privacy of the behavioral and/or environmental data (e.g., collected by one or more sensors) of a user by not exposing it outside the protected device. A recurrent neural network (RNN)-based deep learning algorithm is proposed which uses only sensor data of the legitimate user to learn their normal behavior. Prediction error distribution (PED) is used to enhance the detection accuracy. In some embodiments, a minimalist hardware module, dubbed smartphone impostor detector (SID), is integrated into smartphones for self-contained impostor detection.
FILED Wednesday, February 09, 2022
APPL NO 17/668142
ART UNIT 2435 — Cryptography and Security
CURRENT CPC
Electric Digital Data Processing
G06F 21/316 (20130101) Original (OR) Class
G06F 21/604 (20130101)

Wireless Communication Networks
H04W 12/30 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112238 King et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ATOM COMPUTING INC. (Berkeley, California)
ASSIGNEE(S) ATOM COMPUTING INC. (Berkeley, California)
INVENTOR(S) Jonathan King (Berkeley, California);  Benjamin Bloom (Berkeley, California);  Krish Kotru (Berkeley, California);  Brian Lester (Berkeley, California);  Maxwell Parsons (Berkeley, California)
ABSTRACT The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation.
FILED Monday, December 19, 2022
APPL NO 18/068408
ART UNIT 2121 — AI & Simulation/Modeling
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101) Original (OR) Class
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113123 Makin, III et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Board of Trustees of Western Michigan University (Kalamazoo, Michigan)
ASSIGNEE(S) The Board of Trustees of Western Michigan University (Kalamazoo, Michigan)
INVENTOR(S) Robert A. Makin, III (Kalamazoo, Michigan);  Steven Michael Durbin (Kalamazoo, Michigan)
ABSTRACT A method of fabricating a superconducting device includes determining a target transition temperature and utilizing a predefined quantitative relationship between superconducting transition temperature and an order parameter for at least one superconducting material composition is utilized to select a superconductor material composition that is capable of providing a target transition temperature. Process parameters may be controlled to form a superconductor device comprising at least one superconductor material having a material composition providing the target transition temperature.
FILED Tuesday, November 29, 2022
APPL NO 18/070765
ART UNIT 2893 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 22/14 (20130101)
H01L 29/66893 (20130101) Original (OR) Class

Electric solid-state devices not otherwise provided for
H10N 60/01 (20230201)
H10N 60/12 (20230201)
H10N 60/0912 (20230201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113460 Reitz et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) C-Motive Technologies, Inc. (Middleton, Wisconsin)
ASSIGNEE(S) C-Motive Technologies, Inc. (Middleton, Wisconsin)
INVENTOR(S) Graham T. Reitz (Middleton, Wisconsin);  William D. Butrymowicz (Middleton, Wisconsin);  Baoyun Ge (Middleton, Wisconsin);  Justin K. Reed (Middleton, Wisconsin);  Daniel C. Ludois (Middleton, Wisconsin)
ABSTRACT An electrostatic machine includes a drive electrode and a stator electrode. The drive electrode and the stator electrode are separated by a gap and form a capacitor. The drive electrode is configured to move with respect to the stator electrode. The electrostatic machine further includes a housing configured to enclose the drive electrode and the stator electrode. The stator electrode is fixed to the housing. The electrostatic machine also includes a dielectric fluid that fills a void defined by the housing, the drive electrode, and the stator electrode. The dielectric fluid includes a ketone, malonate, or an oxalate.
FILED Thursday, September 12, 2019
APPL NO 17/293223
ART UNIT 2834 — Electrical Circuits and Systems
CURRENT CPC
Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 3/441 (20130101)
H01B 3/445 (20130101)

Electric Machines Not Otherwise Provided for
H02N 1/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 12110407 Rolin et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S) Terry D. Rolin (Elkmont, Alabama);  Cameroun Grace Sherrard (Huntsville, Alabama);  Ian Kent Small (Centennial, Colorado)
ABSTRACT A humidity sensitive material includes a lanthanum-doped barium titanate (BaTiO3) co-doped with an alkali hydroxide. A polymeric liquid binder is used as a vehicle to deliver the humidity sensitive material to a substrate or electrode via a 3D-printing process. The humidity sensitive material is highly sensitive to changes in humidity and exhibits rapid and large changes in capacitance and impedance for just a relatively small change in humidity. The humidity sensitive material exhibits significantly large changes in impedance and capacitance over the entire 10-90% RH range. As a result of the high sensitivity of the humidity sensitive material, the log-linear response is significantly easier to calibrate in humidity sensing devices that use the humidity sensitive material.
FILED Monday, November 28, 2022
APPL NO 18/059088
ART UNIT 1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/52 (20130101)
C01P 2004/62 (20130101)
C01P 2004/64 (20130101)
C01P 2006/40 (20130101)

Treatment of Inorganic Materials, Other Than Fibrous Fillers, to Enhance Their Pigmenting or Filling Properties; Preparation of Carbon Black;
C09C 1/3692 (20130101)
C09C 3/06 (20130101)
C09C 3/041 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/037 (20130101)
C09D 11/52 (20130101) Original (OR) Class
C09D 11/101 (20130101)
C09D 11/102 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/223 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110846 Papas et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Neil A Armstrong Flight Research Center (AFRC)
APPLICANT(S) Aurora Flight Sciences Corporation (Manassas, Virginia)
ASSIGNEE(S) Aurora Flight Sciences Corporation, a subsidiary of The Boeing Company (Manassas, Virginia)
INVENTOR(S) Gary Richard Papas (Manassas, Virginia);  Neil Titchener (Manassas, Virginia);  Brian M. Yutko (Manassas, Virginia);  Clint Church (Manassas, Virginia);  Jian Long Tian (Manassas, Virginia)
ABSTRACT An aircraft with an integrated boundary layer ingesting propulsion having a mechanically-distributed propulsion system. The mechanically-distributed propulsion system may include an engine to generate a mechanical drive power, a drive shaft, a direction-reversing transmission, and a propulsor fan. The drive shaft may be operatively coupled to the engine to receive the mechanical drive power. The direction-reversing transmission may have a first rotating shaft and a second rotating shaft, the first rotating shaft operatively coupled to the drive shaft to receive the mechanical drive power, which is configured to redirect the mechanical drive power received at the first rotating shaft from a first direction to face a second direction at the second rotating shaft. The propulsor fan may be coupled to the second rotating shaft to convert the mechanical drive power into thrust.
FILED Thursday, May 27, 2021
APPL NO 17/332085
ART UNIT 3619 — Static Structures, Supports and Furniture
CURRENT CPC
Aeroplanes; Helicopters
B64C 1/16 (20130101)
B64C 21/01 (20230101)

Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 27/14 (20130101)
B64D 33/04 (20130101)
B64D 35/00 (20130101)

Jet-propulsion Plants
F02K 3/062 (20130101) Original (OR) Class

Gearing
F16H 1/222 (20130101)
F16H 37/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12113259 Chattopadhyay et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
Federally Funded Research and Development Center (FFRDC)
Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S) Goutam Chattopadhyay (Pasadena, California);  Robert H. Lin (Chino, California);  Sven L. Van Berkel (Pasadena, California);  Sofia Rahiminejad (Pasadena, California)
ABSTRACT Low-loss terahertz switches with nanometer resolution positioning and feedback are disclosed. In one embodiment, the switch uses a U-bend waveguide surrounded by an electromagnetic band gap and is implemented in a fully metal-machined fashion in combination with a piezo-electric motor and an optical linear encoder. In another embodiment, the switch comprises a MEMS device.
FILED Tuesday, June 21, 2022
APPL NO 17/845762
ART UNIT 2874 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/3578 (20130101)

Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type
H01P 1/02 (20130101)
H01P 1/122 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 12108756 France et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) TDA Research, Inc (Wheat Ridge, Colorado)
ASSIGNEE(S) TDA Research, Inc. (Wheat Ridge, Colorado)
INVENTOR(S) Christopher Brian France (Arvada, Colorado);  William Bell (Boulder, Colorado)
ABSTRACT We describe methods and materials for inhibiting the growth of a microbial pathogen of a plant. The method comprises the steps of applying to the plant a combination of a dye-bearing compound which is a reactive oxygen species photosensitizer; and a copper compound, which increases the microbial lethality of the dye-bearing compound towards the microbial pathogen; and exposing the plant to light to activate the combination of the dye-bearing compound and the copper compound and inhibiting growth of a microbial pathogen of a plant. The combination of the dye-bearing compound and the copper compound may result in a synergistic ability to reduce the growth of a plant pathogen.
FILED Tuesday, September 24, 2019
APPL NO 17/278657
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/00 (20130101) Original (OR) Class
A01N 59/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12110310 Chang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Technology Transfer (STTR)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ASSIGNEE(S) UTAH STATE UNIVERSITY (North Logan, Utah)
INVENTOR(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ABSTRACT The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of:
where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases.
FILED Monday, January 25, 2021
APPL NO 17/157752
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7036 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/23 (20130101) Original (OR) Class
C07H 15/234 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 12110310 Chang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Technology Transfer (STTR)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ASSIGNEE(S) UTAH STATE UNIVERSITY (North Logan, Utah)
INVENTOR(S) Cheng-Wei Tom Chang (Logan, Utah);  Jon Y Takemoto (North Logan, Utah)
ABSTRACT The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of:
where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases.
FILED Monday, January 25, 2021
APPL NO 17/157752
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7036 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/23 (20130101) Original (OR) Class
C07H 15/234 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12112238 King et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ATOM COMPUTING INC. (Berkeley, California)
ASSIGNEE(S) ATOM COMPUTING INC. (Berkeley, California)
INVENTOR(S) Jonathan King (Berkeley, California);  Benjamin Bloom (Berkeley, California);  Krish Kotru (Berkeley, California);  Brian Lester (Berkeley, California);  Maxwell Parsons (Berkeley, California)
ABSTRACT The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation.
FILED Monday, December 19, 2022
APPL NO 18/068408
ART UNIT 2121 — AI & Simulation/Modeling
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101) Original (OR) Class
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 12110504 Siprashvili et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  The United States Government as represented by the Department of Veterans Affairs (Washington, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California);  The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Zurab Siprashvili (San Mateo, California);  Ngon T. Nguyen (Union City, California);  M. Peter Marinkovich (Redwood City, California);  Jean Tang (Stanford, California);  Alfred T. Lane (Los Altos, California);  Paul A. Khavari (Palo Alto, California)
ABSTRACT Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
FILED Friday, November 03, 2023
APPL NO 18/501837
ART UNIT 1638 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/0058 (20130101)
A61K 48/0075 (20130101)
A61K 48/0091 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0629 (20130101) Original (OR) Class
C12N 2510/00 (20130101)
C12N 2760/16043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 12110101 Shultz et al.
FUNDED BY
APPLICANT(S) Textron Innovations Inc. (Providence, Rhode Island)
ASSIGNEE(S) Textron Innovations Inc. (Providence, Rhode Island)
INVENTOR(S) David Shultz (Haslet, Texas);  Bryan Baskin (Arlington, Texas);  Jason Owens (Lewisville, Texas);  Robert Self (Fort Worth, Texas);  Paul Sherrill (Grapevine, Texas);  Nicholas Allen Torske (Flower Mound, Texas)
ABSTRACT A rotorcraft has a rotor blade having a spar comprising an internal space. A weight system is disposed within the spar and the weight system includes a weight tray having an open top, a weight guide rod connected to the weight tray. The weight guide rod extends in a spanwise direction through an interior of the weight tray and a weight is disposed on the weight guide rod and vertically captured by at least one side wall of the weight tray. The weight guide rod is insertable into the weight tray from a location above the weight tray to restrict longitudinal movement of the weight guide rod relative to the weight tray.
FILED Monday, March 06, 2023
APPL NO 18/178897
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Aeroplanes; Helicopters
B64C 27/001 (20130101)
B64C 27/008 (20130101) Original (OR) Class
B64C 27/473 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

How To Use This Page 

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, October 08, 2024.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20241008.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

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