FedInvent™ Patents

Patent Details for Tuesday, December 10, 2024 

This page was updated on Tuesday, December 10, 2024 at 07:04 PM GMT

Department of Health and Human Services (HHS) 

US 12161288 Wilder Smith et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S) Petra Beate Wilder Smith (San Juan Capistrano, California);  Rongguang Liang (Tucson, Arizona)
ABSTRACT An oral and oropharyngeal cancer screening system and associated methods are disclosed. In at least one embodiment, the screening system provides an at least one oral and oropharyngeal cancer screening device configured for selectively capturing images of an oropharyngeal area of an at least one patient. The screening device provides an elongate, relatively compact housing, a distal end of the housing being selectively bendable. An imaging module is positioned within the housing, the imaging module providing a lens, an at least one light source, and an imaging sensor positioned in the distal end of the housing. A user application resides in memory on an at least one user device in selective communication with the at least one screening device. The user application is configured for receiving images captured by the at least one screening device and recording risk factors, automatically analyzing the captured images and potential health-risk factors to screen for OPML and oral and oropharyngeal risk.
FILED Monday, July 22, 2019
APPL NO 17/258989
ART UNIT 3795 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/05 (20130101)
A61B 1/24 (20130101)
A61B 1/043 (20130101)
A61B 1/0051 (20130101)
A61B 1/000095 (20220201) Original (OR) Class
A61B 1/000096 (20220201)
A61B 1/0676 (20130101)
A61B 5/7264 (20130101)
A61B 5/7275 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161463 Dassau et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts);  JOSLIN DIABETES CENTER, INC. (Boston, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts);  JOSLIN DIABETES CENTER, INC. (Boston, Massachusetts)
INVENTOR(S) Eyal Dassau (Acton, Massachusetts);  Alejandro J. Laguna Sanz (Cambridge, Massachusetts);  Mary-Elizabeth Rueckel Patti (Newton, Massachusetts);  Francis J. Doyle, III (Chestnut Hill, Massachusetts)
ABSTRACT The present disclosure provides a hypoglycemia prediction algorithm (HPA) specifically designed for the unique postprandial glycemic patterns characteristic of PBH. This algorithm can predict impending hypoglycemia by performing a series of steps. The steps can include collecting data from at least one sensor. The data can comprise a concentration of glucose in the bloodstream of a subject. The data can be processed using the HPA and impending glucose concentrations can be calculated. The method can then provide for determining whether the predicted glucose concentrations are lower than a hypoglycemic threshold parameter. In response to determining that the predicted glucose concentrations are lower than the hypoglycemic threshold parameter, the method can provide for enacting an impending hypoglycemia protocol.
FILED Friday, June 08, 2018
APPL NO 16/003338
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0031 (20130101)
A61B 5/746 (20130101)
A61B 5/4839 (20130101)
A61B 5/7203 (20130101)
A61B 5/7275 (20130101)
A61B 5/7282 (20130101)
A61B 5/14503 (20130101)
A61B 5/14532 (20130101) Original (OR) Class

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/26 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/1723 (20130101)
A61M 2205/35 (20130101)
A61M 2205/50 (20130101)
A61M 2230/201 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161478 Heldman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio)
ASSIGNEE(S) Great Lakes NeuroTechnologies Inc. (Cleveland, Ohio)
INVENTOR(S) Dustin A. Heldman (Shaker Heights, Ohio);  Joseph P. Giuffrida (Hinckley, Ohio)
ABSTRACT A system and method for scoring movement disorder symptoms comprises a movement measurement data acquisition system and processing comprising kinematic feature extraction and an algorithm trained using Unified Parkinson's Disease Rating Scale (UPDRS) scores from skilled clinicians. The movement data acquisition system, or “movement measuring apparatus,” may comprise sensors such as accelerometers or gyroscopes or may utilize motion capture and/or machine vision technology or various other methods to measure tremor, bradykinesia, dyskinesia, or other movement disorders in a subject afflicted with Parkinson's disease, essential tremor or the like. The method outputs, and system displays, a score that uses the same scale as the UPDRS but has greater resolution and lower variability. In some embodiments, the system is used to diagnose and/or treat the patient by providing recommendations for treatment and/or by supplying treatment in the form of pharmaceutical drugs and/or electric stimulus as part of a closed-loop system.
FILED Wednesday, May 18, 2022
APPL NO 17/747425
ART UNIT 3626 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 5/1101 (20130101)
A61B 5/4082 (20130101) Original (OR) Class
A61B 5/6824 (20130101)
A61B 5/6826 (20130101)
A61B 5/7264 (20130101)
A61B 5/7282 (20130101)
A61B 2562/0219 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/198 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/1723 (20130101)
A61M 2230/63 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36067 (20130101)
A61N 1/36139 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 40/63 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161505 Glide-Hurst et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Delphinus Medical Technologies, Inc. (Novi, Michigan)
ASSIGNEE(S) Delphinus Medical Technologies, Inc. (Novi, Michigan)
INVENTOR(S) Carri K. Glide-Hurst (Novi, Michigan);  Nebojsa Duric (Novi, Michigan);  Peter J. Littrup (Novi, Michigan)
ABSTRACT A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.
FILED Friday, December 07, 2018
APPL NO 16/212760
ART UNIT 3797 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/4312 (20130101)
A61B 8/15 (20130101)
A61B 8/085 (20130101)
A61B 8/406 (20130101)
A61B 8/0825 (20130101) Original (OR) Class
A61B 8/0858 (20130101)
A61B 8/4281 (20130101)
A61B 8/4494 (20130101)
A61B 8/5223 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161618 Brugarolas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S) James B. Brugarolas (Irving, Texas);  Haley Hill (Seattle, Washington);  Tao Wang (Coppell, Texas)
ABSTRACT The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.
FILED Friday, January 06, 2023
APPL NO 18/093840
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/275 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101)
G01N 33/5044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161621 Johnson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF COLORADO (, None)
INVENTOR(S) Richard J. Johnson (Centennial, Colorado);  Miguel A. Lanaspa-Garcia (Denver, Colorado);  Sondra Bland (Erie, Colorado)
ABSTRACT The invention relates to the use of one or more fructokinase (ketohexokinase) (KHK) inhibitors to both prevent and treat a wide variety of diseases including, but not limited to, alcohol craving, alcohol addiction, alcohol induced liver disease including a fatty liver and cirrhosis.
FILED Tuesday, July 16, 2019
APPL NO 17/261279
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/37 (20130101) Original (OR) Class
A61K 31/37 (20130101)
A61K 31/713 (20130101)
A61K 36/00 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
A61P 25/32 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161632 Pavliv et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Cumberland Pharmaceuticals Inc. (Nashville, Tennessee);  Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S) Cumberland Pharmaceuticals Inc. (Nashville, Tennessee);  Vanderbilt University (Nashville, Tennessee)
INVENTOR(S) Leo Pavliv (Cary, North Carolina);  Bryan Voss (Nashville, Tennessee);  James West (Nashville, Tennessee);  Erica Carrier (Nashville, Tennessee)
ABSTRACT The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.
FILED Monday, April 10, 2023
APPL NO 18/132480
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/00 (20130101)
A61K 9/0019 (20130101)
A61K 9/2059 (20130101)
A61K 9/4858 (20130101)
A61K 31/421 (20130101) Original (OR) Class
A61K 31/422 (20130101)

Heterocyclic Compounds
C07D 263/30 (20130101)
C07D 407/04 (20130101)
C07D 413/04 (20130101)
C07D 493/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161635 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Zhenghe Wang (Beachwood, Ohio);  Yujun Hao (Shanghai, China PRC);  Yamu Li (Cleveland Heights, Ohio)
ABSTRACT A method of treating PIK3CA helical domain mutant cancer in a subject in need thereof includes administering to the subject therapeutically effective amounts of (i) an inhibitor of nuclear translocation of p85β and/or an EZH inhibitor in combination with (ii) a PI3K inhibitor.
FILED Wednesday, December 22, 2021
APPL NO 17/559280
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4439 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161641 Sadee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S) Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S) Wolfgang Sadee (Upper Arlington, Ohio);  John Oberdick (Columbus, Ohio)
ABSTRACT Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includes administering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.
FILED Monday, February 22, 2021
APPL NO 17/180945
ART UNIT 1628 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/485 (20130101) Original (OR) Class
A61K 31/485 (20130101)
A61K 31/4178 (20130101)
A61K 31/4178 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/36 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161642 Corson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Eye Institute (NEI)
APPLICANT(S) INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana);  Gachon University of Industry-Academic Cooperation (Gyeonggi-do, South Korea)
ASSIGNEE(S) INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana);  Gachon University of Industry Academic Cooperation (Gyeonggi-do, South Korea)
INVENTOR(S) Timothy W. Corson (Fishers, Indiana);  Kamakshi Sishtla (Indianapolis, Indiana);  Seung-Yong Seo (Gyeonggi-do, South Korea);  Bit Lee (Gyeonggi-do, South Korea)
ABSTRACT The invention relates to a method of treatment of a patient with a ferrochelatase inhibitor, or a pharmaceutically acceptable salt thereof, or a derivative thereof. Also, the invention relates to a method of treatment of a patient with a ferrochelatase inhibitor that is a triazolopyrimidinone, or a derivative thereof, or a pharmaceutically acceptable salt thereof.
FILED Tuesday, April 30, 2019
APPL NO 17/051018
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/37 (20130101)
A61K 31/49 (20130101)
A61K 31/122 (20130101)
A61K 31/155 (20130101)
A61K 31/343 (20130101)
A61K 31/409 (20130101)
A61K 31/519 (20130101) Original (OR) Class
A61K 31/4025 (20130101)
A61K 31/4196 (20130101)
A61K 31/4706 (20130101)
A61K 31/4709 (20130101)
A61K 38/17 (20130101)
A61K 38/179 (20130101)
A61K 39/3955 (20130101)
A61K 41/0057 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/02 (20180101)

Heterocyclic Compounds
C07D 249/14 (20130101)
C07D 487/04 (20130101)

Peptides
C07K 16/22 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101)
C12N 2310/11 (20130101)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161647 Edge et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
INVENTOR(S) Albert Edge (Brookline, Massachusetts);  Hideyuki Okano (Tokyo, Japan);  Masato Fujioka (Tokyo, Japan);  Kunio Mizutari (Tokyo, Japan)
ABSTRACT This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.
FILED Thursday, December 10, 2020
APPL NO 17/118111
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0046 (20130101)
A61K 31/55 (20130101) Original (OR) Class
A61K 47/10 (20130101)
A61K 47/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161649 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Nathanael S. Gray (Boston, Massachusetts);  Jaebong Jang (Boston, Massachusetts);  Dries De Clercq (Wetteren, Belgium);  David A. Scott (Boston, Massachusetts)
ABSTRACT The application relates to compounds, or pharmaceutically acceptable salts, hydrates, solvates, or stereoisomers thereof, which modulate the activity of EGFR, a pharmaceutical composition comprising said compounds, and methods of treating or preventing a disease in which EGFR plays a role.
FILED Friday, June 21, 2019
APPL NO 17/251559
ART UNIT 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0012 (20130101)
A61K 31/5513 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 243/14 (20130101)
C07D 401/12 (20130101)
C07D 403/04 (20130101)
C07D 403/12 (20130101)
C07D 403/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161650 Marcantonio et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) ARMGO Pharma, Inc. (Ardsley, New York)
ASSIGNEE(S) ARMGO Pharma, Inc. (Ardsley, New York)
INVENTOR(S) Eugene E. Marcantonio (Tenafly, New Jersey);  Mette Uhre Anby (Frederiksberg, Denmark);  Jérôme Binet (Saint Denis en Val, France)
ABSTRACT The present disclosure provides a modified-release pharmaceutical composition comprising 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)yl)methyl]benzoic acid hemifumarate, and a pharmaceutically-acceptable excipient. The present disclosure methods of treating conditions associated with RyRs, including, for example, cardiac disorder or disease, a musculoskeletal disorder or disease, cancer associated muscle weakness, malignant hyperthermia, and diabetes.
FILED Tuesday, July 25, 2023
APPL NO 18/225849
ART UNIT 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/2866 (20130101)
A61K 9/2886 (20130101)
A61K 31/554 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161658 Richter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S) UNIVERSITY OF MASSACHUSETTS (Westborough, Massachusetts)
INVENTOR(S) Joel D. Richter (Boston, Massachusetts);  Fen-Biao Gao (Boston, Massachusetts)
ABSTRACT Translation modulating agents that modulate expression of one or more translation start sites for expanded repeat (e.g., DPR) protein synthesis are provided. Compositions and methods for treating translation start sites for expanded repeat (e.g., DPR) protein synthesis-associated disorders are also provided.
FILED Tuesday, December 22, 2020
APPL NO 17/130908
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/711 (20130101)
A61K 31/712 (20130101)
A61K 31/7088 (20130101)
A61K 31/7105 (20130101) Original (OR) Class
A61K 31/7115 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/113 (20130101)
C12N 2310/314 (20130101)
C12N 2310/321 (20130101)
C12N 2310/322 (20130101)
C12N 2310/3233 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161659 Lu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Zheng-Rong Lu (Cleveland, Ohio);  Anthony Malamas (Cleveland, Ohio);  Maneesh Gujrati (Cleveland, Ohio);  Da Sun (Cleveland, Ohio)
ABSTRACT A compound comprising formula (I): wherein R1 is an alkylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.
FILED Tuesday, September 28, 2021
APPL NO 17/487562
ART UNIT 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 48/0033 (20130101)

Peptides
C07K 5/0606 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
C12N 2320/31 (20130101)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161664 Boss et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Regents of the University of California (Oakland, California);  The Regents of the University of Colorado (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  The Regents of the University of Colorado (Denver, Colorado)
INVENTOR(S) Gerry R. Boss (La Jolla, California);  Adriano Chan (La Jolla, California);  Matthew Brenner (Irvine, California);  Sari Brenner Mahon (Irvine, California);  Vikhyat Bebarta (Denver, Colorado)
ABSTRACT Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate.
FILED Tuesday, August 20, 2019
APPL NO 17/271284
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0043 (20130101)
A61K 33/04 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/52 (20130101)
G01N 2800/709 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161671 Ahmed et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Emory University (Atlanta, Georgia);  St. Jude Children's Hospital, Inc. (Memphis, Tennessee)
ASSIGNEE(S) Emory University (Atlanta, Georgia);  St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee)
INVENTOR(S) Rafi Ahmed (Atlanta, Georgia);  Benjamin Youngblood (Decatur, Georgia)
ABSTRACT This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.
FILED Tuesday, May 25, 2021
APPL NO 17/330378
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
A61P 35/00 (20180101)

Peptides
C07K 14/005 (20130101)
C07K 14/70596 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 5/0638 (20130101)
C12N 9/1007 (20130101)
C12N 2510/00 (20130101)
C12N 2740/16033 (20130101)
C12N 2740/16111 (20130101)

Enzymes
C12Y 201/01037 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161672 Wu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Chia-Yung Wu (San Francisco, California);  James Onuffer (Alameda, California);  Wendell A. Lim (San Francisco, California)
ABSTRACT The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.
FILED Wednesday, September 14, 2022
APPL NO 17/932259
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 47/6891 (20170801)
A61K 2039/505 (20130101)

Peptides
C07K 14/705 (20130101)
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 14/70575 (20130101)
C07K 14/70578 (20130101)
C07K 16/18 (20130101)
C07K 16/2803 (20130101)
C07K 16/2866 (20130101)
C07K 2317/622 (20130101)
C07K 2319/00 (20130101)
C07K 2319/03 (20130101)
C07K 2319/20 (20130101)
C07K 2319/33 (20130101)
C07K 2319/74 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 9/14 (20130101)
C12N 9/90 (20130101)
C12N 2510/00 (20130101)

Enzymes
C12Y 502/01008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161680 Norman et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
APPLICANT(S) Vedanta Biosciences, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S) Vedanta Biosciences, Inc. (Cambridge, Massachusetts)
INVENTOR(S) Jason Norman (North Weymouth, Massachusetts);  Bernat Olle (Cambridge, Massachusetts);  Bruce Roberts (Framingham, Massachusetts);  Rajita Menon (Brighton, Massachusetts)
ABSTRACT Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.
FILED Friday, August 16, 2019
APPL NO 17/268781
ART UNIT 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/742 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161691 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Texas A and M University System (College Station, Texas);  University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas);  University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S) Zhilei Chen (College Station, Texas);  Rudo Simeon (Bryan, Texas);  Ana M. Chamoun-Emanuelli (College Station, Texas);  Zeyu Peng (Kunming, China PRC);  Hanping Feng (Baltimore, Maryland);  Hua Yu (Columbia, Maryland);  Yongrong Zhang (Columbia, Maryland)
ABSTRACT In an embodiment, the present disclosure pertains to a method of treating or preventing C. difficile infections. In some embodiments, the method includes administering an antitoxin to a subject in need thereof. In some embodiments, the antitoxin includes a designed ankyrin repeat protein (DARPin). In an additional embodiments, the present disclosure pertains to a composition including an antitoxin for treating or preventing C. difficile infections. In some embodiments, the anti-toxin includes a DARPin. In some embodiments, the anti-toxin is a monomeric or dimeric DARPin for the neutralization of Clostridium difficile toxin B (TcdB).
FILED Monday, May 11, 2020
APPL NO 17/609818
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/164 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 39/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161694 Wallrapp et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Antonia Wallrapp (Boston, Massachusetts);  Samantha J. Riesenfeld (Cambridge, Massachusetts);  Patrick R. Burkett (Boston, Massachusetts);  Monika S. Kowalczyk (Cambridge, Massachusetts);  Aviv Regev (Cambridge, Massachusetts);  Vijay K. Kuchroo (Boston, Massachusetts)
ABSTRACT Computational and functional analysis identified the neuropeptide receptor Nmur1 as selectively expressed on Type 2 innate lymphoid cells (ILC2s). While both IL-33 and IL-25 promote ILC activation in vivo, IL-33 induces robust ILC proliferation, whereas ILCs activated with IL-25 do not proliferate as robustly and up-regulate Nmur1 expression. Treatment with neuromedin U (NMU), the neuropeptide ligand of Nmur1, had little effect on its own. Co-administration of IL-25 with NMU, however, dramatically amplified allergic lung inflammation and induced the proliferation and expansion of specific ILC2 subsets, characterized by a molecular signature unique to pro-inflammatory ILC2s. The results demonstrate that Nmur1 signaling strongly modulates IL-25-mediated ILC2 responses, resulting in highly proliferative pro-inflammatory ILCs, and highlights the importance of neuro-immune crosstalk in allergic inflammatory responses at mucosal surfaces.
FILED Friday, March 23, 2018
APPL NO 16/497105
ART UNIT 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0073 (20130101)
A61K 38/20 (20130101) Original (OR) Class
A61K 38/22 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/08 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161698 Sen Gupta et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Anirban Sen Gupta (Cleveland, Ohio);  Christa Pawloski (Seven Hills, Ohio)
ABSTRACT A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic platelet also including a therapeutic agent, wherein the therapeutic agent is encapsulated by the nanoparticle, wherein the synthetic platelet adheres to the site targeted and promotes delivery of the therapeutic agent onto sites of the synthetic platelet adhesion, and wherein the therapeutic agent is released at the site targeted via a site-relevant enzyme.
FILED Tuesday, September 13, 2022
APPL NO 17/943955
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/19 (20130101)
A61K 9/127 (20130101)
A61K 9/1271 (20130101)
A61K 9/4825 (20130101)
A61K 38/00 (20130101)
A61K 38/39 (20130101) Original (OR) Class
A61K 38/177 (20130101)
A61K 38/185 (20130101)
A61K 38/1774 (20130101)
A61K 47/62 (20170801)
A61K 47/6911 (20170801)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Peptides
C07K 14/78 (20130101)
C07K 14/195 (20130101)
C07K 14/745 (20130101)
C07K 14/70596 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161701 Goodman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio)
ASSIGNEE(S) RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio)
INVENTOR(S) Steven David Goodman (Columbus, Ohio);  Lauren Opremcak Bakaletz (Columbus, Ohio)
ABSTRACT Provided herein are methods to inhibit or disrupt a bio film comprising contacting the bio film with an agent that cleaves the Holliday junction (HJ) structure in the bio film.
FILED Friday, October 04, 2019
APPL NO 17/282341
ART UNIT 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/54 (20130101)
A61K 38/465 (20130101) Original (OR) Class

Enzymes
C12Y 301/22004 (20130101)
C12Y 306/04012 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161709 Weissman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) Drew Weissman (Wynnewood, Pennsylvania);  Norbert Pardi (Philadelphia, Pennsylvania);  Michael Hogan (Philadelphia, Pennsylvania)
ABSTRACT The present invention relates to compositions and methods for inducing an adaptive immune response against Zika virus (ZIKV) in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof.
FILED Wednesday, December 22, 2021
APPL NO 17/559190
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5123 (20130101)
A61K 39/12 (20130101) Original (OR) Class
A61K 2039/53 (20130101)
A61K 2039/55 (20130101)
A61K 2039/545 (20130101)
A61K 2039/55511 (20130101)
A61K 2039/55555 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2770/24134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161726 Kent et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio);  Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Ohio State Innovation Foundation (Columbus, Ohio);  Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) K. Craig Kent (Columbus, Ohio);  Shaoqin Gong (Middleton, Wisconsin);  Lianwang Guo (Columbus, Ohio);  Bowen Wang (Columbus, Ohio);  Guojun Chen (Madison, Wisconsin);  Go Urabe (Columbus, Ohio)
ABSTRACT The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
FILED Friday, September 16, 2022
APPL NO 17/932736
ART UNIT 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5153 (20130101)
A61K 45/06 (20130101)
A61K 47/6937 (20170801) Original (OR) Class

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161733 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S) Xiaoyuan Chen (Potomac, Maryland);  Orit Jacobson Weiss (Silver Spring, Maryland)
ABSTRACT A compound of Formula I or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: wherein the definitions of R1-R13 and L1-L4 are provided in the disclosure, and wherein R14 is a group capable of binding to prostate-specific membrane antigen (PSMA).
FILED Friday, February 22, 2019
APPL NO 16/969673
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4025 (20130101)
A61K 45/06 (20130101)
A61K 47/547 (20170801)
A61K 49/0052 (20130101)
A61K 51/0497 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161734 Bradbury et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
APPLICANT(S) Sloan-Kettering Institute for Cancer Research (New York, New York);  Cornell University (Ithaca, New York)
ASSIGNEE(S) Sloan-Kettering Institute for Cancer Research (New York, New York);  Cornell University (Ithaca, New York)
INVENTOR(S) Michelle S. Bradbury (New York, New York);  Ulrich Wiesner (Ithaca, New York);  Oula Penate Medina (Kiel, Germany);  Andrew Burns (Niskayuna, New York);  Jason S. Lewis (New York, New York);  Steven M. Larson (New York, New York)
ABSTRACT The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.
FILED Tuesday, July 05, 2022
APPL NO 17/857413
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0002 (20130101)
A61K 49/0093 (20130101)
A61K 51/1244 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/60 (20130101)
G01N 33/552 (20130101)
G01N 33/574 (20130101)
G01N 33/582 (20130101)
G01N 33/587 (20130101)
G01N 33/54346 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161766 Mao et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Hai-Quan Mao (Baltimore, Maryland);  Jose Luis Santos (Rockville, Maryland);  Yong Ren (Baltimore, Maryland);  John-Michael Williford (Chicago, Illinois)
ABSTRACT The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.
FILED Tuesday, February 07, 2023
APPL NO 18/165436
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5115 (20130101)
A61K 9/5146 (20130101)
A61K 9/5161 (20130101)
A61K 9/5169 (20130101)
A61K 9/5192 (20130101) Original (OR) Class
A61K 47/61 (20170801)
A61K 47/6455 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161781 Reddy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Sashank Reddy (Baltimore, Maryland);  Russell Martin (Baltimore, Maryland);  Xiaowei Li (Towson, Maryland);  Calvin Chang (Baltimore, Maryland);  Kevin Colbert (Baltimore, Maryland);  Hai-Quan Mao (Baltimore, Maryland)
ABSTRACT A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
FILED Thursday, May 09, 2019
APPL NO 17/054156
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/18 (20130101)
A61L 27/20 (20130101)
A61L 27/44 (20130101)
A61L 27/48 (20130101)
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/56 (20130101)
A61L 27/58 (20130101) Original (OR) Class
A61L 27/3808 (20130101)
A61L 27/3834 (20130101)
A61L 27/3895 (20130101)
A61L 2300/412 (20130101)
A61L 2300/414 (20130101)
A61L 2300/602 (20130101)
A61L 2300/604 (20130101)
A61L 2300/622 (20130101)
A61L 2400/06 (20130101)
A61L 2400/12 (20130101)
A61L 2430/34 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/19 (20130101)
A61M 2202/08 (20130101)
A61M 2202/09 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161859 Risi et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Cochlear Limited (Macquarie University, Australia);  University of Washington Center for Commercialization (Seattle, Washington)
ASSIGNEE(S) Cochlear Limited (Macquarie University, Australia);  University of Washington Center for Commercialization (Seattle, Washington)
INVENTOR(S) Frank Risi (Newtown, Australia);  Colin Irwin (Nice, France);  Jay T. Rubinstein (Seattle, Washington);  Felipe Santos (Boston, Massachusetts);  James O. Phillips (Seattle, Washington)
ABSTRACT A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.
FILED Tuesday, January 31, 2023
APPL NO 18/162340
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/361 (20130101)
A61N 1/0526 (20130101) Original (OR) Class
A61N 1/0551 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161861 Bhadra et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Niloy Bhadra (Cleveland Heights, Ohio);  Kevin L. Kilgore (Avon Lake, Ohio);  Narendra Bhadra (Chesterland, Ohio);  Jesse Wainright (Willoughby Hills, Ohio);  Tina Vrabec (Willoughby Hills, Ohio);  Manfred Franke (South Euclid, Ohio)
ABSTRACT Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
FILED Monday, November 21, 2022
APPL NO 17/991045
ART UNIT 3796 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/06 (20130101)
A61N 1/20 (20130101)
A61N 1/0556 (20130101) Original (OR) Class
A61N 1/36064 (20130101)
A61N 1/36067 (20130101)
A61N 1/36071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161889 Shusta et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Eric V. Shusta (Madison, Wisconsin);  Charles C. Stutz (Waltham, Massachusetts)
ABSTRACT The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
FILED Wednesday, July 24, 2019
APPL NO 17/260697
ART UNIT 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)

Peptides
C07K 16/28 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161890 Zanini et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) CZ Biohub SF, LLC (San Francisco, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) CZ Biohub SF, LLC (San Francisco, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Fabio Zanini (Stanford, California);  Derek Croote (Stanford, California);  Makeda L. Robinson (Stanford, California);  Leslie Goo (San Francisco, California);  Stephen R. Quake (San Francisco, California);  Shirit Einav (Stanford, California);  Krista McCutcheon (San Francisco, California);  Eric Waltari (San Francisco, California)
ABSTRACT Provided are antibodies or antigen binding portions thereof that specifically bind Dengue virus, various compositions of such antibodies or antigen binding portions thereof, and methods of their use. Provided are such antibodies, fragments of such antibodies retaining Dengue virus-binding ability, pharmaceutical compositions including such antibodies or antigen binding fragments thereof, and diagnostic compositions including such antibodies or antigen binding fragments thereof. Also provided are isolated nucleic acids encoding such antibodies, amino acid sequences of such antibodies, and host cells transformed therewith. Additionally, provided are prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the disclosure.
FILED Wednesday, August 07, 2019
APPL NO 17/265704
ART UNIT 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101) Original (OR) Class
G01N 33/56983 (20130101)
G01N 2333/185 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162818 Rettig et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Matthew Rettig (Los Angeles, California);  Michael E. Jung (Los Angeles, California);  D. Elshan Nakath G. Ralalage (Los Angeles, California);  Jiabin An (Los Angeles, California)
ABSTRACT The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
FILED Thursday, January 13, 2022
APPL NO 17/575027
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Acyclic or Carbocyclic Compounds
C07C 33/486 (20130101)
C07C 49/223 (20130101)
C07C 225/16 (20130101) Original (OR) Class
C07C 235/34 (20130101)
C07C 235/78 (20130101)
C07C 321/20 (20130101)

Heterocyclic Compounds
C07D 207/08 (20130101)
C07D 211/32 (20130101)
C07D 241/04 (20130101)
C07D 265/30 (20130101)
C07D 303/32 (20130101)
C07D 303/40 (20130101)
C07D 307/52 (20130101)
C07D 333/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162846 Tieu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) Kim Tieu (Miami, Florida);  Adel Nefzi (Miami, Florida);  Stephen Black (Miami, Florida)
ASSIGNEE(S) THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S) Kim Tieu (Miami, Florida);  Adel Nefzi (Miami, Florida);  Stephen Black (Miami, Florida)
ABSTRACT The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.
FILED Tuesday, February 06, 2024
APPL NO 18/433879
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/496 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)
A61P 25/16 (20180101)

Heterocyclic Compounds
C07D 277/42 (20130101) Original (OR) Class
C07D 417/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162861 Newman et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Rockville, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S) Amy Hauck Newman (Phoenix, Arizona);  Vivek Kumar (Baltimore, Maryland);  Anver Basha Shaik (Baltimore, Maryland)
ABSTRACT Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.
FILED Thursday, March 03, 2022
APPL NO 17/685709
ART UNIT 1621 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/36 (20180101)

Heterocyclic Compounds
C07D 403/12 (20130101) Original (OR) Class
C07D 405/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162901 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Child Health and Human Development (NICHD)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Xi Chen (Davis, California);  An Xiao (Davis, California);  Anoopjit Kooner (Davis, California);  Abhishek Santra (Davis, California);  Ajit Varki (San Diego, California);  Hai Yu (Davis, California);  Lee-Ping Wang (Davis, California);  Wanqing Li (Davis, California)
ABSTRACT The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
FILED Thursday, September 30, 2021
APPL NO 17/491518
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 15/04 (20130101) Original (OR) Class
C07H 15/12 (20130101)
C07H 15/14 (20130101)
C07H 15/203 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/28 (20130101)
C12P 19/44 (20130101)
C12P 19/64 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162910 Franchini et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  New York University (New York, New York)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  New York University (New York, New York)
INVENTOR(S) Genoveffa Franchini (Washington, District of Columbia);  Timothy Cardozo (New York, New York);  Manuel Becerra-Flores (Brooklyn, New York);  Isabela Silva de Castro (Bethesda, Maryland);  Giacomo Gorini (Bethesda, Maryland);  Massimiliano Bissa (Washington, District of Columbia)
ABSTRACT Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
FILED Monday, October 21, 2019
APPL NO 17/285453
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 39/21 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Peptides
C07K 14/162 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56988 (20130101)
G01N 2333/16 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162912 Kennedy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Matthew Kennedy (Denver, Colorado);  Chandra Tucker (Denver, Colorado)
ABSTRACT The present invention includes light-controlled and light-independent neurotoxin systems and methods for using such neurotoxin systems for rapidly and locally silencing distinct populations of neurons.
FILED Thursday, November 21, 2019
APPL NO 17/295736
ART UNIT 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/33 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/52 (20130101)
C12N 15/62 (20130101)

Enzymes
C12Y 304/24069 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162916 Chackerian et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNM Rainforest Innovations (Albuquerque, New Mexico)
ASSIGNEE(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  Bryce Chackerian (Albuquerque, New Mexico);  Kiran Bhaskar (Albuquerque, New Mexico);  Jonathan Hulse (Albuquerque, New Mexico)
INVENTOR(S) Bryce Chackerian (Albuquerque, New Mexico);  Kiran Bhaskar (Albuquerque, New Mexico);  Jonathan P. Hulse (Albuquerque, New Mexico)
ABSTRACT An immunogen includes an immunogenic carrier and an antigenic apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) peptide linked to the immunogenic carrier. In one or more embodiments, the immunogenic carrier is a Qβ virus-like particle (VLP). The immunogen may be formulated into a composition useful for treating inflammatory medical conditions.
FILED Tuesday, April 16, 2024
APPL NO 18/637070
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/00115 (20180801)
A61K 2039/5258 (20130101)

Peptides
C07K 14/4747 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2795/18123 (20130101)
C12N 2795/18134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162924 Raines et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Ronald T. Raines (Madison, Wisconsin);  Ismet Tanrikulu (Madison, Wisconsin)
ABSTRACT Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclosed.
FILED Friday, December 17, 2021
APPL NO 17/554650
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Peptides
C07K 14/78 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162926 Lai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Albert Einstein College of Medicine (Bronx, New York)
ASSIGNEE(S) Albert Einstein College of Medicine (Bronx, New York)
INVENTOR(S) Jonathan R. Lai (Dobbs Ferry, New York);  Julia Frei (Bronx, New York);  Elisabeth Nyakatura (New York, New York)
ABSTRACT Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor.
FILED Tuesday, September 28, 2021
APPL NO 17/487690
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/42 (20130101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/64 (20130101)
C07K 2317/76 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162928 Noelle et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire);  KING'S COLLEGE LONDON (London, United Kingdom)
ASSIGNEE(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire);  KING'S COLLEGE LONDON (London, United Kingdom)
INVENTOR(S) Randolph J. Noelle (Plainfield, New Hampshire);  Sabrina Ceeraz (Lebanon, New Hampshire);  Isabelle LeMercier (Enfield, New Hampshire);  Elizabeth Nowak (West Lebanon, New Hampshire);  Janet Lines (London, United Kingdom)
ABSTRACT The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.
FILED Thursday, July 30, 2020
APPL NO 16/943413
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101)
A01K 2217/075 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0325 (20130101)
A01K 2267/0368 (20130101)
A01K 2267/0387 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/00 (20130101)
A61K 38/00 (20130101)
A61K 39/39 (20130101)
A61K 39/395 (20130101)
A61K 39/3955 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 14/70503 (20130101)
C07K 14/70532 (20130101)
C07K 16/18 (20130101) Original (OR) Class
C07K 16/2827 (20130101)
C07K 2317/76 (20130101)
C07K 2319/30 (20130101)
C07K 2319/32 (20130101)
C07K 2319/735 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1138 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162929 Sigurdsson
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S) NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S) Einar M. Sigurdsson (Scarsdale, New York)
ABSTRACT The present disclosure is directed to single domain antibodies that bind to α-synuclein and the use of these antibodies for the treatment and diagnosis of α-synucleinopathies The present disclosure is also directed to polynucleotides encoding the α-synuclein single domain antibodies, therapeutic vectors comprising these polynucleotides and methods of administering these therapeutic vectors for the treatment of α-synucleinopathies.
FILED Tuesday, February 19, 2019
APPL NO 16/971157
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/18 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/22 (20130101)
C07K 2317/24 (20130101)
C07K 2317/569 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6896 (20130101)
G01N 2800/28 (20130101)
G01N 2800/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162939 Jaiswal et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Siddhartha Jaiswal (San Francisco, California);  Irving L. Weissman (Stanford, California);  Ravindra Majeti (Palo Alto, California);  Mark P. Chao (Mountain View, California)
ABSTRACT Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, acute leukemia cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.
FILED Wednesday, April 07, 2021
APPL NO 17/224722
ART UNIT 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39558 (20130101)
A61K 47/6851 (20170801)
A61K 47/6861 (20170801)
A61K 47/6863 (20170801)
A61K 47/6865 (20170801)
A61K 47/6867 (20170801)
A61K 47/6869 (20170801)
A61K 2039/505 (20130101)
A61K 2039/507 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Peptides
C07K 16/18 (20130101)
C07K 16/28 (20130101)
C07K 16/30 (20130101)
C07K 16/2803 (20130101) Original (OR) Class
C07K 16/2896 (20130101)
C07K 16/3038 (20130101)
C07K 16/3046 (20130101)
C07K 16/3053 (20130101)
C07K 16/3061 (20130101)
C07K 16/3069 (20130101)
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/73 (20130101)
C07K 2317/75 (20130101)
C07K 2317/76 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0093 (20130101)
C12N 5/0694 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/136 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101)
G01N 33/57426 (20130101)
G01N 2500/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162950 Kipps et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Thomas James Kipps (San Diego, California);  Jian Yu (San Diego, California);  Bing Cui (San Diego, California);  Liguang Chen (San Diego, California);  George F. Widhopf, II (San Diego, California);  Charles Prussak (San Diego, California)
ABSTRACT The present invention relates to pharmaceutical compositions and a method of inhibiting metastasis using anti-ROR1 antibodies or antigen binding fragments, ROR1 binding peptides and ROR1 vaccines.
FILED Wednesday, March 16, 2022
APPL NO 17/696776
ART UNIT RD00 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/001102 (20180801)
A61K 2039/505 (20130101)
A61K 2039/6081 (20130101)

Peptides
C07K 14/435 (20130101)
C07K 16/30 (20130101) Original (OR) Class
C07K 16/2803 (20130101)
C07K 16/3015 (20130101)
C07K 2317/34 (20130101)
C07K 2317/73 (20130101)
C07K 2317/92 (20130101)
C07K 2317/94 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162953 Saltzman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Yale University (New Haven, Connecticut);  New York University (New York, New York)
ASSIGNEE(S) YALE UNIVERSITY (New Haven, Connecticut);  NEW YORK UNIVERSITY (New York, New York)
INVENTOR(S) W. Mark Saltzman (New Haven, Connecticut);  Gregory T. Tietjen (New Haven, Connecticut);  Shohei Koide (New York, New York);  Claire Albert (New Haven, Connecticut);  Jordan Pober (New Haven, Connecticut);  Akiko Koide (New York, New York);  Laura Bracaglia (New Haven, Connecticut)
ABSTRACT A platform technology provides particle and nucleic acid conjugates, and compositions thereof, with enhanced targeting to cells, tissues, organs. The particles and nucleic acids and other deliverables contain a synthetic binding protein such as a polypeptide monobody covalently conjugated to the surface of the particle or the nucleic acid, for linking a targeting agent to the particle's surface or the nucleic acid. The particles and nucleic acids and other deliverables optionally contain an antibody non-covalently conjugated to the binding protein, via an Fc domain of the antibody. The particles can include therapeutic agents, diagnostic agents, prophylactic agents, or a combination thereof, to be delivered to desired cells, tissues, and/or organs. The particles and nucleic acids and other deliverables can be used in a wide array of applications including, but not limited to, ex vivo perfusion of mammalian organs and in vivo disease treatment.
FILED Friday, December 04, 2020
APPL NO 17/112964
ART UNIT 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/44 (20130101) Original (OR) Class
C07K 2317/34 (20130101)
C07K 2317/92 (20130101)
C07K 2317/569 (20130101)
C07K 2319/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162955 Krusemark et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Casey J. Krusemark (West Lafayette, Indiana);  Emily C. Dykhuizen (West Lafayette, Indiana);  Sijie Wang (Lafayette, Indiana)
ABSTRACT The present invention relates to series of peptidomimetic compounds selectively targeting CBX8 of polycomb chromobox protein homolog proteins. Pharmaceutical compositions of those compounds and methods of using them in the treatment of diseases involved CBX8 pharmacology, including various cancers and leukemia, by administering therapeutically effective amounts of such compound alone or together with other therapeutics, are within the scope of this disclosure.
FILED Tuesday, January 31, 2023
APPL NO 18/103694
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Peptides
C07K 5/1016 (20130101)
C07K 7/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162960 Chaikof et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts);  Emory University (Atlanta, Georgia)
ASSIGNEE(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts);  Emory University (Atlanta, Georgia)
INVENTOR(S) Elliot Chaikof (Newton, Massachusetts);  Richard D. Cummings (Brookline, Massachusetts);  Venkata R. Krishnamurthy (Ashland, Massachusetts);  Mohammed Sardar (Boston, Massachusetts)
ABSTRACT This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one or more modified amino acids conjugated to a saccharide or polysaccharide. In certain embodiments, the disclosure relates to uses of the glycopeptides as anti-inflammatory, antithrombotic, or anti-metastatic agents.
FILED Wednesday, March 13, 2019
APPL NO 16/352585
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 7/08 (20130101)
C07K 9/00 (20130101) Original (OR) Class
C07K 14/70564 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163124 Yin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Hao Yin (Cambridge, Massachusetts);  Wen Xue (Cambridge, Massachusetts);  Daniel G. Anderson (Framingham, Massachusetts);  Joseph R. Dorkin (Somerville, Massachusetts);  Tyler E. Jacks (Newton, Massachusetts)
ABSTRACT The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.
FILED Monday, March 08, 2021
APPL NO 17/195625
ART UNIT 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/85 (20130101)
C12N 15/86 (20130101)
C12N 15/88 (20130101)
C12N 15/102 (20130101) Original (OR) Class
C12N 15/111 (20130101)
C12N 2310/20 (20170501)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163130 Schaefer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Icahn School of Medicine at Mount Sinai (New York, New York);  The Rockefeller University (New York, New York)
ASSIGNEE(S) Icahn School of Medicine at Mount Sinai (New York, New York);  The Rockefeller University (New York, New York)
INVENTOR(S) Anne Schaefer (New York, New York);  Paul Greengard (New York, New York);  Chan Lek Tan (San Francisco, California)
ABSTRACT The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
FILED Monday, November 16, 2020
APPL NO 17/099209
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 67/0276 (20130101)
A01K 2217/052 (20130101)
A01K 2217/075 (20130101)
A01K 2217/203 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0356 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/185 (20130101)
A61K 49/0008 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
A61P 25/08 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
C12N 2310/315 (20130101)
C12N 2310/321 (20130101)
C12N 2310/321 (20130101)
C12N 2310/341 (20130101)
C12N 2310/346 (20130101)
C12N 2310/3515 (20130101)
C12N 2310/3521 (20130101)
C12N 2310/3521 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5058 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163148 Yeo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Regents of the University of California (La Jolla, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Eugene Yeo (La Jolla, California);  Kristopher Brannan (La Jolla, California);  Ryan Marina (La Jolla, California);  David Nelles (La Jolla, California)
ABSTRACT Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.
FILED Monday, July 11, 2022
APPL NO 17/811626
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/85 (20130101) Original (OR) Class
C12N 15/113 (20130101)
C12N 2310/20 (20170501)
C12N 2740/16043 (20130101)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163166 Rajan
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S) Rakhi Rajan (Norman, Oklahoma)
ABSTRACT Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
FILED Friday, March 25, 2022
APPL NO 17/704317
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/74 (20130101)
C12N 15/113 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163168 Stone et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Everett Stone (Austin, Texas);  Wei-Cheng Lu (Austin, Texas);  Christos Karamitros (Austin, Texas)
ABSTRACT Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-γ-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.
FILED Friday, October 25, 2019
APPL NO 17/288151
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/225 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 45/06 (20130101)
A61K 47/60 (20170801)

Peptides
C07K 2319/30 (20130101)
C07K 2319/31 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/88 (20130101) Original (OR) Class

Enzymes
C12Y 404/01001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163181 Church et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Office of Science Consolidated Service Center (CSC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) George M. Church (Brookline, Massachusetts);  Kun Zhang (Brighton, Massachusetts);  Joseph Chou (Jamaica Plain, Massachusetts)
ABSTRACT Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.
FILED Wednesday, October 14, 2020
APPL NO 17/070190
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6813 (20130101) Original (OR) Class
C12Q 1/6837 (20130101)
C12Q 1/6837 (20130101)
C12Q 1/6837 (20130101)
C12Q 2535/113 (20130101)
C12Q 2535/113 (20130101)
C12Q 2535/113 (20130101)
C12Q 2537/143 (20130101)
C12Q 2537/143 (20130101)
C12Q 2537/143 (20130101)
C12Q 2565/543 (20130101)
C12Q 2565/543 (20130101)
C12Q 2565/543 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163953 Whitten et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S) STC.UNM (Albuquerque, New Mexico)
INVENTOR(S) David G. Whitten (Albuquerque, New Mexico);  Harry Craig Pappas (Albuquerque, New Mexico);  Eric H. Hill (Donostia, Spain);  Yue Zhang (Albuquerque, New Mexico);  Eva Yung Hua Chi (Albuquerque, New Mexico);  Arjun Thapa (Oklahoma City, Oklahoma);  Ying Wang (Albuquerque, New Mexico);  Patrick L Donabedian (Albuquerque, New Mexico);  Kiran Bhaskar (Albuquerque, New Mexico)
ABSTRACT Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
FILED Monday, December 09, 2019
APPL NO 16/707501
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Peptides
C07K 14/65 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/02 (20130101)
C08G 2261/94 (20130101)
C08G 2261/312 (20130101)
C08G 2261/3328 (20130101)
C08G 2261/3422 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/44 (20130101)
C12Q 1/46 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/52 (20130101) Original (OR) Class
G01N 2333/916 (20130101)
G01N 2333/918 (20130101)
G01N 2800/2828 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163959 Xu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) Xiaowei Xu (Monmouth Junction, New Jersey);  Wei Guo (Wynnewood, Pennsylvania);  Gang Chen (Philadelphia, Pennsylvania)
ABSTRACT Compositions and methods are disclosed for treating cancer patients and identifying patients with a malignancy that are likely to respond to treatment with anti-PD-1/PD-L1 and other anti-cancer and immune-modulating therapeutics.
FILED Friday, November 09, 2018
APPL NO 16/762440
ART UNIT 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5743 (20130101)
G01N 33/57423 (20130101)
G01N 33/57488 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163960 Shao et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Jieya Shao (St. Louis, Missouri);  Marc Diamond (St. Louis, Missouri)
ABSTRACT The present disclosure provides methods to quantify VCP phosphorylation at specific amino acid residue to predict responsiveness of a subject having a cancer or tumor to a genotoxic treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
FILED Friday, May 07, 2021
APPL NO 17/315061
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/40 (20130101)
C07K 2317/565 (20130101)

Enzymes
C12Y 306/04006 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5088 (20130101)
G01N 33/57496 (20130101) Original (OR) Class
G01N 2333/914 (20130101)
G01N 2440/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163965 Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Emory University (Atlanta, Georgia)
ASSIGNEE(S) Emory University (Atlanta, Georgia)
INVENTOR(S) Frances Eun-Hyung Lee (Atlanta, Georgia);  Ignacio Sanz (Atlanta, Georgia);  Doan C. Nguyen (Atlanta, Georgia)
ABSTRACT This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g., long lived plasma cells, replicating the isolated cells in growth media disclosed herein, and determining the nucleic acids sequences in the cells that encode the produced antibodies.
FILED Wednesday, August 18, 2021
APPL NO 17/405918
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/163 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5091 (20130101)
G01N 33/6854 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164688 Dekleva et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Space and Naval Warfare Systems Center (SPAWAR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Brian Dekleva (Pittsburgh, Pennsylvania);  Jennifer Lynn Collinger (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein are methods and systems for transient-based decoding of neural signals. In one aspect, a device such as a brain-computer interface (BCI), includes at least one processor configured to receive a plurality of neural signals from a subject. The at least one processor can detect, from the plurality of neural signals, first neural activity unique to a first defined temporal window corresponding to an onset phase of an intended action of the subject. The at least one processor can detect, from the plurality of neural signals, second neural activity unique to a second defined temporal window, occurring after the first temporal window and corresponding to an offset phase of the intended action. The at least one processor can generate at least one output indicative of the intended action, responsive to detecting at least one of the first neural activity or the second neural activity.
FILED Wednesday, September 07, 2022
APPL NO 17/939893
ART UNIT 2625 — Selective Visual Display Systems
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/372 (20210101)

Electric Digital Data Processing
G06F 3/015 (20130101) Original (OR) Class
G06F 3/0484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165036 Du et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
INVENTOR(S) Yong Du (Lutherville-Timonium, Maryland);  Kevin H. Leung (Baltimore, Maryland);  Martin Gilbert Pomper (Baltimore, Maryland)
ABSTRACT Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
FILED Thursday, December 07, 2023
APPL NO 18/531928
ART UNIT 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/045 (20230101) Original (OR) Class
G06N 3/0985 (20230101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10104 (20130101)
G06T 2207/10108 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30016 (20130101)

Image or Video Recognition or Understanding
G06V 10/44 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165670 Mesgarani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
Directorate of Geosciences (GEO)
Office of Polar Programs (OPP)
The Office of Polar Programs Antarctic (ANT)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Nima Mesgarani (New York, New York);  Yi Luo (New York, New York);  James O'Sullivan (New York, New York);  Zhuo Chen (New York, New York)
ABSTRACT Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated).
FILED Monday, July 31, 2023
APPL NO 18/228239
ART UNIT RD00 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/12 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 17/26 (20130101)
G10L 21/0272 (20130101)
G10L 25/30 (20130101) Original (OR) Class
G10L 25/66 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165743 Cleary et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (, None);  Massachusetts Institute of Technology (, None)
INVENTOR(S) Brian Cleary (Cambridge, Massachusetts);  Aviv Regev (Cambridge, Massachusetts);  Eric S. Lander (Cambridge, Massachusetts)
ABSTRACT The present invention relates to tissue and cell imaging utilizing genomic informatics and gene-expression profiling. Gene-expression profiles utilized in methods to obtain in situ imaging of cells and tissues provide complex molecular fingerprints regarding the relative state of a cell or tissue.
FILED Tuesday, November 12, 2019
APPL NO 16/681639
ART UNIT 1672 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6874 (20130101)

Image Data Processing or Generation, in General
G06T 5/50 (20130101)
G06T 2207/20224 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 25/10 (20190201) Original (OR) Class
G16B 50/50 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165747 Regev et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Aviv Regev (Cambridge, Massachusetts);  Johanna Klughammer (Cambridge, Massachusetts);  Daniel Abravanel (Boston, Massachusetts)
ABSTRACT The present invention discloses novel methods and uses thereof for producing molecular spatial maps of metastatic breast cancer (MBC) and ductal carcinoma in situ of the breast (DCIS). A specific list of genes are identified using single-cell RNA sequencing and single-nucleus RNA sequencing and are used for RNA visualization of MBC and DCIS tissue microenvironment. Unexpected subtypes of tumor cells are revealed, and methods for identifying molecular biomarkers for MBC in the bone and breast and DCIS are disclosed. Furthermore, methods for identifying therapeutic agents and uses thereof for treating MBC and DCIS as well as compositions thereof comprising such identified therapeutic agents are provided.
FILED Friday, January 22, 2021
APPL NO 17/156392
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0693 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6841 (20130101)
C12Q 1/6886 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 25/10 (20190201)
G16B 45/00 (20190201) Original (OR) Class

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/40 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 12161114 Cutler et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Sean R Cutler (Riverside, California);  Aditya Vaidya (Riverside, California);  Jonathan Helander (St. Louis, Missouri)
ABSTRACT The present invention sets forth small novel abscisic acid (ABA) receptor agonist scaffolds and compounds with potent in vivo activity. In some aspects, the present invention provides agricultural formulations and methods comprising the ABA receptor agonists described herein, such as methods of managing crop water use and improving stress tolerance (e.g., drought tolerance). In some preferred embodiments, the inventive compounds have improved properties relative to the current “best in-class” molecules quinabactin and its derivatives.
FILED Monday, December 28, 2020
APPL NO 17/135194
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 37/34 (20130101)
A01N 41/10 (20130101)
A01N 43/40 (20130101) Original (OR) Class

Acyclic or Carbocyclic Compounds
C07C 255/60 (20130101)
C07C 317/28 (20130101)

Heterocyclic Compounds
C07D 213/56 (20130101)
C07D 213/61 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161189 Gusenoff et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Jeffrey A. Gusenoff (Pittsburgh, Pennsylvania);  Beth R. Gusenoff (Pittsburgh, Pennsylvania);  Steven Regis Donahoe (Pittsburgh, Pennsylvania)
ABSTRACT An insole for offloading injuries on an area of a plantar surface of a patient's foot includes a body having a shape corresponding to the plantar surface of the patient's foot including a top surface and a bottom surface; and at least one supportive, deformable, deflatable bubble chamber. The at least one bubble chamber extends from the top surface of the body. The at least one bubble chamber is configured to be deflated to relieve pressure on the plantar surface of the patient's foot. A kit including the insole and an article of footwear including a sole, an upper connected about a periphery of the sole defining an interior of the article of footwear, and the insole positioned in the interior of the article, are also provided.
FILED Friday, September 20, 2019
APPL NO 17/277916
ART UNIT 3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Characteristic Features of Footwear; Parts of Footwear
A43B 7/142 (20130101)
A43B 7/144 (20130101)
A43B 7/1445 (20130101)
A43B 17/03 (20130101) Original (OR) Class
A43B 17/006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161592 Bush et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S) Tamara Reid Bush (Pinckney, Michigan);  Justin Scott (Lansing, Michigan)
ABSTRACT An articulating chair and a method of using same, include at least one actuator, a programmable controller, and movable upper back, lower back and seat bottom sections. In another aspect, an articulating wheelchair and a method of using same, include a seat bottom section, a lower frame to which the seat bottom section is coupled, floor-contacting wheels rotatably coupled to the lower frame, an upper back section, a lower back section, a back frame to which the upper back section and the lower back section are movably coupled, electromagnetic actuators coupled to the back sections, a battery mounted to at least one of the frames, and a programmable controller connected to the actuators and the battery.
FILED Tuesday, June 25, 2024
APPL NO 18/752877
ART UNIT 3636 — Static Structures, Supports and Furniture
CURRENT CPC
Chairs; Sofas; Beds
A47C 1/0242 (20130101)
A47C 7/144 (20180801)
A47C 7/285 (20130101)
A47C 7/462 (20130101)

Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices
A61G 5/122 (20161101)
A61G 5/124 (20161101)
A61G 5/1056 (20130101) Original (OR) Class
A61G 5/1072 (20130101)

Seats Specially Adapted for Vehicles; Vehicle Passenger Accommodation Not Otherwise Provided for
B60N 2/6673 (20150401)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161781 Reddy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Sashank Reddy (Baltimore, Maryland);  Russell Martin (Baltimore, Maryland);  Xiaowei Li (Towson, Maryland);  Calvin Chang (Baltimore, Maryland);  Kevin Colbert (Baltimore, Maryland);  Hai-Quan Mao (Baltimore, Maryland)
ABSTRACT A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.
FILED Thursday, May 09, 2019
APPL NO 17/054156
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/18 (20130101)
A61L 27/20 (20130101)
A61L 27/44 (20130101)
A61L 27/48 (20130101)
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/56 (20130101)
A61L 27/58 (20130101) Original (OR) Class
A61L 27/3808 (20130101)
A61L 27/3834 (20130101)
A61L 27/3895 (20130101)
A61L 2300/412 (20130101)
A61L 2300/414 (20130101)
A61L 2300/602 (20130101)
A61L 2300/604 (20130101)
A61L 2300/622 (20130101)
A61L 2400/06 (20130101)
A61L 2400/12 (20130101)
A61L 2430/34 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/19 (20130101)
A61M 2202/08 (20130101)
A61M 2202/09 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161996 Gao et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S) UNIVERSITY OF CONNECTICUT (Farmington, Connecticut)
INVENTOR(S) Pu-Xian Gao (Coventry, Connecticut);  Son Hoang (Corona, New York)
ABSTRACT Metal oxide nanoarrays, such as titanium oxide nanoarrays, having a platinum group metal dispersed thereon and methods of making such nanoarrays are described. The platinum group metal can be dispersed on the metal oxide nanoarray as single atoms. The nanoarrays can be used to catalyze oxidation of combustion exhaust.
FILED Thursday, May 04, 2023
APPL NO 18/143559
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Separation
B01D 53/865 (20130101)
B01D 2255/1021 (20130101)
B01D 2255/20707 (20130101)
B01D 2258/012 (20130101)
B01D 2259/4566 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/063 (20130101) Original (OR) Class
B01J 23/42 (20130101)
B01J 35/19 (20240101)
B01J 35/23 (20240101)
B01J 35/40 (20240101)
B01J 35/56 (20240101)
B01J 35/58 (20240101)
B01J 37/10 (20130101)
B01J 37/0217 (20130101)
B01J 37/344 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162035 Chang et al.
FUNDED BY
Department of Defense (DOD)
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Chih-hung Chang (Corvallis, Oregon);  Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon);  Yujuan He (Corvallis, Oregon);  Jeffrey Dhas (Corvallis, Oregon);  Brian K. Paul (Corvallis, Oregon);  Somayeh Pasebani (Corvallis, Oregon);  Chuankai Song (Corvallis, Oregon);  Sakineh Abbasi (Corvallis, Oregon)
ABSTRACT A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces.
FILED Tuesday, July 26, 2022
APPL NO 17/814914
ART UNIT 1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 1/28 (20130101)
B05B 7/0075 (20130101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/12 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162050 Hale et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Mike Hale (Hopewell Junction, New York);  Keith Hale (Hopewell Junction, New York);  Melinda Sims (Seattle, Washington)
ABSTRACT A system for extracting landfill gas from a landfill is provided. According to some embodiments, a control system for landfill gas extraction is provided. The control system uses a throttle to control flow of landfill gas extracted from the landfill. The throttle is actuated in use to vary the flow of gas between a well and a gas collection system, in accordance with a control algorithm that adjusts flow as a parameter in controlling gas extraction. The throttle is configured to ensure that there is at least some flow of landfill gas from the landfill to a gas output throughout operation. The extraction system provides an efficient system for landfill gas extraction, while mitigating a risk of creating undesired or unpleasant conditions and/or of violating regulations during operation.
FILED Monday, May 01, 2023
APPL NO 18/310343
ART UNIT 3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/12 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 50/30 (20130101)

Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management
Y02W 30/30 (20150501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162053 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (North Potomac, Maryland)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, April 10, 2023
APPL NO 18/132753
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 43/12 (20130101)
E21B 47/06 (20130101)
E21B 49/087 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162218 Kim et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
Federally Funded Research and Development Center (FFRDC)
Operated by California Institute of Technology (CALTECH) at Pasadena, CA
National Science Foundation (NSF)
Office of The Director (OD)
Office of International Science and Engineering (OISE)
APPLICANT(S) THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (Las Vegas, Nevada)
ASSIGNEE(S) THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (Las Vegas, Nevada)
INVENTOR(S) Kwang J. Kim (Henderson, Nevada);  Alexandrea Washington (Las Vegas, Nevada);  Emma Chao (Henderson, Nevada);  Justin Neubauer (Las Vegas, Nevada);  Sophia Leon (Las Vegas, Nevada);  Zachary Frank (Las Vegas, Nevada);  Zakai Olsen (Las Vegas, Nevada)
ABSTRACT A modular and expandable 3D printer frame includes frame members to be coupled together to form a base defining an inner area. Each frame member includes at least one coupling member to removably couple the frame member to another of the frame members. The printer frame further includes first modular plates to be disposed within the inner area, and second modular plates to be disposed within the inner area and removably coupled to the first modular plates. The first and second modular plates, when coupled together, define a printer footprint.
FILED Wednesday, December 04, 2019
APPL NO 17/428424
ART UNIT 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/25 (20170801) Original (OR) Class
B29C 64/209 (20170801)
B29C 64/295 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 30/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162575 Ouyang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida)
ASSIGNEE(S) Florida Atlantic University Board of Trustees (Boca Raton, Florida)
INVENTOR(S) Bing Ouyang (Fort Pierce, Florida);  Tsung-Chow Su (Boca Raton, Florida);  Yanjun Li (Fort Pierce, Florida);  Jordan Thomas (Boca Raton, Florida)
ABSTRACT Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion.
FILED Friday, April 09, 2021
APPL NO 17/226913
ART UNIT 3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/106 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects
B63C 11/52 (20130101) Original (OR) Class

Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers
B63G 8/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162629 Cooley et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
National High Magnetic Field Laboratory (NHMFL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Lance D. Cooley (Tallahassee, Florida);  Christian M. Hubicki (Tallahassee, Florida)
ABSTRACT Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module.
FILED Tuesday, November 22, 2022
APPL NO 17/992588
ART UNIT 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/002 (20130101) Original (OR) Class

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/02 (20130101)
H01F 6/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162962 Edgar et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia);  Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia);  Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Kevin J. Edgar (Blacksburg, Virginia);  Brittany L. B. Nichols (Blacksburg, Virginia);  Junyi Chen (Blacksburg, Virginia);  Charles Frazier (Blacksburg, Virginia);  Lynne S. Taylor (West Lafayette, Indiana);  Laura I. Mosquera-Giraldo (West Lafayette, Indiana);  Ann Norris (Blacksburg, Virginia)
ABSTRACT A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.
FILED Thursday, June 09, 2022
APPL NO 17/836338
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Polysaccharides; Derivatives Thereof
C08B 11/04 (20130101)
C08B 11/20 (20130101)
C08B 31/12 (20130101)
C08B 31/185 (20130101)
C08B 33/04 (20130101)
C08B 37/003 (20130101) Original (OR) Class
C08B 37/0021 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162997 Scott et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Evan A. Scott (Chicago, Illinois);  Sean D. Allen (Chicago, Illinois)
ABSTRACT Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
FILED Monday, September 20, 2021
APPL NO 17/448151
ART UNIT 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/107 (20130101)
A61K 9/1273 (20130101)
A61K 31/352 (20130101)
A61K 31/365 (20130101)
A61K 31/436 (20130101)
A61K 38/465 (20130101)
A61K 47/34 (20130101)
A61K 47/36 (20130101)
A61K 49/0047 (20130101)
A61K 49/0054 (20130101)
A61K 49/0065 (20130101)

Mixing, e.g Dissolving, Emulsifying, Dispersing
B01F 23/41 (20220101)
B01F 23/45 (20220101)
B01F 25/20 (20220101)
B01F 25/23 (20220101)
B01F 33/30 (20220101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/14 (20130101) Original (OR) Class
C08J 2371/02 (20130101)
C08J 2381/02 (20130101)
C08J 2381/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
C12N 2320/32 (20130101)

Enzymes
C12Y 301/03001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163166 Rajan
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S) Rakhi Rajan (Norman, Oklahoma)
ABSTRACT Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
FILED Friday, March 25, 2022
APPL NO 17/704317
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/74 (20130101)
C12N 15/113 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163177 Gonzalez et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Ramon Gonzalez (Tampa, Florida)
ASSIGNEE(S) Ramon Gonzalez (Tampa, Florida)
INVENTOR(S) Ramon Gonzalez (Tampa, Florida);  James M. Clomburg (Tampa, Florida)
ABSTRACT Methods of using microorganisms to make chemicals and fuels, including carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives are described. Native or engineered thiolases are used condense a growing acyl-ACP and acetyl-ACP in combination with type II fatty acid synthesis. The resulting fatty acid biosynthesis cycle has an ATP yield analogous to the functional reverse β-oxidation cycle.
FILED Tuesday, April 05, 2022
APPL NO 17/713480
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/6409 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163183 Sardar et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana)
ASSIGNEE(S) INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana)
INVENTOR(S) Rajesh Sardar (Avon, Indiana);  Thakshila Liyanage (Indianapolis, Indiana);  Adrianna Masterson (Indianapolis, Indiana);  Hristos Z. Kaimakliotis (Zionsville, Indiana)
ABSTRACT Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.
FILED Tuesday, October 22, 2019
APPL NO 17/283977
ART UNIT 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6825 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163186 Mancebo
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Ricardo Mancebo (Hayward, California)
ASSIGNEE(S) Ricardo Mancebo (Hayward, California)
INVENTOR(S) Ricardo Mancebo (Hayward, California)
ABSTRACT The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (ACR).
FILED Monday, May 02, 2022
APPL NO 17/734226
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6853 (20130101) Original (OR) Class
C12Q 1/6862 (20130101)
C12Q 1/6862 (20130101)
C12Q 2523/109 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163409 Mehrvand et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Eden GeoPower, Inc. (Somerville, Massachusetts)
ASSIGNEE(S) Eden GeoPower, Inc. (Somerville, Massachusetts)
INVENTOR(S) Mehrdad Mehrvand (Somerville, Massachusetts);  Ammar Alali (Cambridge, Massachusetts)
ABSTRACT Systems and methods for deployment of electric-based fracturing tools in vertical wells. A method of electric-based fracturing may include lowering an electrical stimulation tool into a wellbore using a drill pipe and isolating a lower portion of the wellbore that is downhole from an upper portion of the wellbore. The electrical stimulation tool may be disposed in the lower portion of the wellbore. A system for electric-based fracturing may include an isolation mechanism and an electrical stimulation tool. The isolation mechanism may be configured to expand from a retracted configuration spaced from an interior surface of a wellbore to an expanded configuration in contact with the inner surface of the wellbore. The electrical stimulation tool may be operatively coupled with the isolation mechanism and may be configured to be disposed distally relative to the isolation mechanism when positioned in the wellbore.
FILED Wednesday, August 30, 2023
APPL NO 18/458798
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 33/16 (20130101)
E21B 43/26 (20130101) Original (OR) Class
E21B 43/2401 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163421 Cardiff
FUNDED BY
Environmental Protection Agency (EPA)
National Science Foundation (NSF)
Directorate of Geosciences (GEO)
Division of Earth Sciences (EAR)
Department of Agriculture (USDA)
U.S. Forest Service (FS)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Michael Cardiff (Madison, Wisconsin)
ABSTRACT A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation.
FILED Wednesday, March 15, 2023
APPL NO 18/121904
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/12 (20130101)
E21B 49/008 (20130101) Original (OR) Class
E21B 2200/20 (20200501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163496 Son et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for STEM Education (EDU)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Steven Forrest Son (West Lafayette, Indiana);  Kyle Uhlenhake (Lafayette, Indiana);  Diane Collard (West Lafayette, Indiana);  Mateo Gomez (West Lafayette, Indiana)
ABSTRACT An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers.
FILED Friday, December 01, 2023
APPL NO 18/527230
ART UNIT 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Jet-propulsion Plants
F02K 9/95 (20130101)

Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines
F02P 23/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163929 Eriten et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Melih Eriten (Madison, Wisconsin);  Corinne R. Henak (Madison, Wisconsin)
ABSTRACT A noncontact vibration measurement enables detection of acoustic emissions from fracture events in soft materials experimentally determined to be highly correlated to fracture energies, the latter revealing the toughness of the material.
FILED Tuesday, April 19, 2022
APPL NO 17/659680
ART UNIT 2852 — Printing/Measuring and Testing
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/40 (20130101) Original (OR) Class
G01N 29/04 (20130101)
G01N 29/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163953 Whitten et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S) STC.UNM (Albuquerque, New Mexico)
INVENTOR(S) David G. Whitten (Albuquerque, New Mexico);  Harry Craig Pappas (Albuquerque, New Mexico);  Eric H. Hill (Donostia, Spain);  Yue Zhang (Albuquerque, New Mexico);  Eva Yung Hua Chi (Albuquerque, New Mexico);  Arjun Thapa (Oklahoma City, Oklahoma);  Ying Wang (Albuquerque, New Mexico);  Patrick L Donabedian (Albuquerque, New Mexico);  Kiran Bhaskar (Albuquerque, New Mexico)
ABSTRACT Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
FILED Monday, December 09, 2019
APPL NO 16/707501
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Peptides
C07K 14/65 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/02 (20130101)
C08G 2261/94 (20130101)
C08G 2261/312 (20130101)
C08G 2261/3328 (20130101)
C08G 2261/3422 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/44 (20130101)
C12Q 1/46 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/52 (20130101) Original (OR) Class
G01N 2333/916 (20130101)
G01N 2333/918 (20130101)
G01N 2800/2828 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164066 Ma et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Biwu Ma (Tallahassee, Florida);  Liang-Jin Xu (Tallahassee, Florida);  Qingquan He (Tallahassee, Florida)
ABSTRACT Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.
FILED Friday, March 12, 2021
APPL NO 17/909611
ART UNIT 2884 — Optics
CURRENT CPC
Measurement of Nuclear or X-radiation
G01T 1/2002 (20130101)
G01T 1/2018 (20130101)
G01T 1/2023 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164097 Kolle et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Mathias Kolle (Hull, Massachusetts);  Cecile Chazot (Cambridge, Massachusetts)
ABSTRACT Articles and systems for dark microscopy and related methods are generally described.
FILED Wednesday, December 23, 2020
APPL NO 17/133159
ART UNIT 2872 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/08 (20130101)
G02B 5/09 (20130101)
G02B 5/0825 (20130101)
G02B 17/0673 (20130101)
G02B 21/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164926 Lucia et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Brandon Lucia (Pittsburgh, Pennsylvania);  Nathan Beckmann (Pittsburgh, Pennsylvania);  Graham Gobieski (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is a highly energy-efficient architecture targeting the ultra-low-power sensor domain. The architecture achieves high energy-efficiency while maintaining programmability and generality. The invention introduces vector-dataflow execution, allowing the exploitation of the dataflows in a sequence of vector instructions and to amortize instruction fetch and decode over a whole vector of operations. The vector-dataflow architecture allows the invention to avoid costly vector register file accesses, thereby saving energy.
FILED Wednesday, October 13, 2021
APPL NO 17/500017
ART UNIT 2183 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 9/3802 (20130101)
G06F 9/3838 (20130101) Original (OR) Class
G06F 9/30036 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165004 Pichler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Hannes Pichler (Cambridge, Massachusetts);  Shengtao Wang (Somerville, Massachusetts);  Leo Xiangyu Zhou (Somerville, Massachusetts);  Soonwon Choi (El Cerrito, California);  Mikhail D. Lukin (Cambridge, Massachusetts)
ABSTRACT Systems and methods relate to selectively arranging a plurality of qubits into a spatial structure to encode a quantum computing problem. Exemplary arrangement techniques can be applied to encode various quantum computing problems. The plurality of qubits can be driven according to various driving techniques into a final state. The final state can be measured to identify an exact or approximate solution to the quantum computing problem.
FILED Friday, August 30, 2019
APPL NO 17/270741
ART UNIT 2182 — Computer Architecture and I/O
CURRENT CPC
Optical Computing Devices;
G06E 1/00 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
G06N 10/40 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165670 Mesgarani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
Directorate of Geosciences (GEO)
Office of Polar Programs (OPP)
The Office of Polar Programs Antarctic (ANT)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Nima Mesgarani (New York, New York);  Yi Luo (New York, New York);  James O'Sullivan (New York, New York);  Zhuo Chen (New York, New York)
ABSTRACT Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated).
FILED Monday, July 31, 2023
APPL NO 18/228239
ART UNIT RD00 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/12 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 17/26 (20130101)
G10L 21/0272 (20130101)
G10L 25/30 (20130101) Original (OR) Class
G10L 25/66 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165752 Blundo et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Tyler Blundo (Ringwood, New Jersey);  Christiana Honsberg (Tempe, Arizona);  Stephen Goodnick (Fort McDowell, Arizona);  Richard King (Tempe, Arizona);  Nicholas Irvin (Phoenix, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Tyler Blundo (Ringwood, New Jersey);  Christiana Honsberg (Tempe, Arizona);  Stephen Goodnick (Fort McDowell, Arizona);  Richard King (Tempe, Arizona);  Nicholas Irvin (Phoenix, Arizona)
ABSTRACT A skylight for a building includes a solar panel arranged within the skylight, the solar panel comprising one or more photovoltaic cells to collect direct radiation from rays of sunlight for conversion to electrical power, and an optical element to receive the direct radiation and refract it to the solar panel, and to receive the direct radiation and diffuse radiation scattered from the rays of sunlight and refract the direct radiation and the diffuse radiation through the skylight, bypassing the solar panel, to provide daylighting in the building.
FILED Friday, May 12, 2023
APPL NO 18/316943
ART UNIT 3635 — Static Structures, Supports and Furniture
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6888 (20130101)

Roof Coverings; Sky-lights; Gutters; Roof-working Tools
E04D 13/033 (20130101)

Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates
E06B 9/24 (20130101)
E06B 2009/2417 (20130101)
E06B 2009/2494 (20130101)

Non-portable Lighting Devices; Systems Thereof; Vehicle Lighting Devices Specially Adapted for Vehicle Exteriors
F21S 11/002 (20130101)

Optical Elements, Systems, or Apparatus
G02B 5/32 (20130101)
G02B 5/208 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 25/10 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101) Original (OR) Class
G16H 10/60 (20180101)

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 20/26 (20141201)
H02S 40/22 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165829 Fan
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S) Qi Hua Fan (Okemos, Michigan)
ABSTRACT A single beam plasma or ion source apparatus, including multiple and different power sources, is provided. An aspect of the present apparatus and method employs simultaneous excitation of an ion source by DC and AC, or DC and RF power supplies. Another aspect employs an ion source including multiple magnets and magnetic shunts arranged in a generally E cross-sectional shape.
FILED Thursday, September 23, 2021
APPL NO 17/482833
ART UNIT 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/35 (20130101)
C23C 14/46 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 37/08 (20130101) Original (OR) Class
H01J 2237/0815 (20130101)
H01J 2237/3146 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166504 Kliewer et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S) New Jersey Institute of Technology (Newark, New Jersey)
INVENTOR(S) Joerg Kliewer (Fair Lawn, New Jersey);  Allison Beemer (Eau Claire, Wisconsin);  Salman Habib (Newark, New Jersey)
ABSTRACT Embodiments of the present disclosure relate to sequential decoding of moderate length low-density parity-check (LDPC) codes via reinforcement learning (RL). The sequential decoding scheme is modeled as a Markov decision process (MDP), and an optimized cluster scheduling policy is subsequently obtained via RL. A software agent is trained to schedule all check nodes (CNs) in a cluster, and all clusters in every iteration. A new RL state space model is provided that enables the RL-based decoder to be suitable for longer LDPC codes.
FILED Tuesday, September 27, 2022
APPL NO 17/954120
ART UNIT 2112 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/1125 (20130101)
H03M 13/1128 (20130101)
H03M 13/1131 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166606 Nguyen et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) San Diego State University (SDSU) Foundation (San Diego, California)
ASSIGNEE(S) San Diego State University (SDSU) Foundation (San Diego, California)
INVENTOR(S) Duy H. N. Nguyen (San Marcos, California);  Van Ly Nguyen (San Diego, California)
ABSTRACT A method for designing a channel estimation and data detection networks is provided herein. The problem of channel estimation for linear systems has effectively been solved—not the case for non-linear systems. A deep learning framework for channel estimation, data detection, and pilot signal design is described to address the nonlinearity in such systems.
FILED Friday, March 18, 2022
APPL NO 17/698915
ART UNIT 2631 — Digital Communications
CURRENT CPC
Transmission
H04B 7/0413 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 25/0204 (20130101)
H04L 25/0254 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166622 Prothero et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
APPLICANT(S) Astrapi Corporation (Dallas, Texas)
ASSIGNEE(S) Astrapi Corporation (Dallas, Texas)
INVENTOR(S) Jerrold Prothero (Delray Beach, Florida);  James J. Sterling (Chambersburg, Pennsylvania)
ABSTRACT Systems, devices, and methods of the present invention enhance data transmission through the use of polynomial symbol waveforms (PSW) and sets of PSWs corresponding to a symbol alphabet is here termed a PSW alphabet. Methods introduced here are based on modifying polynomial alphabet by changing the polynomial coefficients or roots of PSWs and/or shaping of the polynomial alphabet, such as by polynomial convolution, to produce a designed PSW alphabet including waveforms with improved characteristics for data transmission.
FILED Sunday, August 06, 2023
APPL NO 18/230652
ART UNIT 2635 — Digital Communications
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 27/363 (20130101)
H04L 27/2639 (20130101)
H04L 27/2647 (20130101)
H04L 27/3405 (20130101) Original (OR) Class
H04L 27/3494 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166952 Redden
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Blue River Technology Inc. (Sunnyvale, California)
ASSIGNEE(S) BLUE RIVER TECHNOLOGY INC. (Santa Clara, California)
INVENTOR(S) Lee Kamp Redden (Palo Alto, California)
ABSTRACT Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on.
FILED Monday, October 02, 2023
APPL NO 18/479504
ART UNIT 2671 — Computer Networks
CURRENT CPC
Electric Digital Data Processing
G06F 18/2415 (20230101)

Image Data Processing or Generation, in General
G06T 7/593 (20170101)
G06T 2207/10021 (20130101)
G06T 2207/20076 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/30252 (20130101)

Image or Video Recognition or Understanding
G06V 10/764 (20220101)
G06V 20/38 (20220101)
G06V 20/188 (20220101)
G06V 2201/12 (20220101)

Pictorial Communication, e.g Television
H04N 13/128 (20180501)
H04N 13/204 (20180501)
H04N 13/239 (20180501)
H04N 13/243 (20180501) Original (OR) Class
H04N 13/271 (20180501)
H04N 2013/0081 (20130101)
H04N 2013/0092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12167184 Fahs et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
U.S. State Government
State of New York
Empire State Development (ESD)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) Rensselaer Polytechnic Institute (Troy, New York)
INVENTOR(S) Bassem Fahs (Troy, New York);  Robert F. Karlicek, Jr. (Mechanicville, New York);  Mona Mostafa Hella (Watervliet, New York)
ABSTRACT A cross-connect switch architecture is described. A cross-connect switch device includes a cross-point switch array, a plurality of photo detectors and a plurality of amplifiers. The cross-point switch array includes a plurality of switches. Each switch is coupled between a respective photo detector and a respective amplifier and is configured to couple the respective photo detector to the respective amplifier when the switch is selected.
FILED Tuesday, April 02, 2019
APPL NO 17/043795
ART UNIT 2874 — Optics
CURRENT CPC
Amplifiers
H03F 3/085 (20130101)

Selecting
H04Q 11/0005 (20130101) Original (OR) Class
H04Q 11/0062 (20130101)
H04Q 2011/0016 (20130101)
H04Q 2011/0024 (20130101)
H04Q 2011/0026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12167527 Xu et al.
FUNDED BY
National Science Foundation (NSF)
Office of The Director (OD)
Office of Integrative Activities (OIA)
APPLICANT(S) The Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama, in Huntsville (Huntsville, Alabama)
ASSIGNEE(S) Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville (Huntsville, Alabama)
INVENTOR(S) Kunning Gabriel Xu (Brownsboro, Alabama);  Ryan Patrick Gott (Summerville, South Carolina)
ABSTRACT The present disclosure is generally directed to a plasma sheet source and methods of using same. The plasma sheet source includes a cylindrical electrode having a conductive cylindrical core surrounded by a dielectric material, a plurality of channels configured to direct gas from a gas inlet to the electrode, and a plasma outlet positioned below the electrode. Gas is introduced to the plasma sheet source and directed toward the electrode, which when powered by pulsed direct current, produces plasma as the gas ionizes. The produced plasma is then directed out of the plasma outlet to a specimen for treatment of the specimen. Notably, the plasma exiting the plasma outlet is in the form of a plasma sheet that is at approximately room temperature.
FILED Thursday, September 28, 2023
APPL NO 18/477242
ART UNIT 2844 — Electrical Circuits and Systems
CURRENT CPC
Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/2439 (20210501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12167541 Xu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S) Baoxing Xu (Charlottesville, Virginia);  Yue Zhang (Philadelphia, Pennsylvania)
ABSTRACT The capillary transfer technology presented here represents a powerful approach to transfer soft films from surface of liquid onto a solid substrate in a fast and defect-free manner. The fundamental theoretical model and transfer criteria validated with comprehensive experiments and finite element analyses, for the first time provides a quantitative guide and optimization for the choice of material systems, operating conditions and environments for scalable on-demand transfers with high yield. The intrinsically moderate capillary transfer force and externally selectable transfer direction offer robust capabilities for achieving deterministic assembly and surface properties of structures with complex layouts and patterns for potentially broad applications in the fabrication of flexible/stretchable electronics, surface wetting structures and optical devices. Integration of this technology with other advanced manufacturing technologies associated with material self-assembly, growth and layout alignment represents promising future topics and would help create emerging new manufacturing technologies that leverage unique fluidity of liquid environments.
FILED Friday, November 20, 2020
APPL NO 17/793910
ART UNIT 2853 — Printing/Measuring and Testing
CURRENT CPC
Producing Decorative Effects; Mosaics; Tarsia Work; Paperhanging
B44C 1/1752 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 3/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 12161479 Mohseni et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Hooman Mohseni (Wilmette, Illinois);  Iman Hassani Nia (Evanston, Illinois);  Skyler Wheaton (Evanston, Illinois)
ABSTRACT A multispectral imaging apparatus includes a processor and a plurality of sets of light-emitting diodes (LEDs) in communication with the processor. One or more first sets of LEDs has a wavelength in a visible range, and one or more second sets of LEDs has a wavelength in a short wavelength infrared range. The apparatus includes a truncated source cone through which light from the plurality of sets of LEDs is directed onto a surface and through which light reflected off of the surface is received. The apparatus also includes a visible light camera configured to capture a first image of the surface based on reflected light that originates from the one or more first sets of LEDS. The apparatus further includes an infrared light camera and configured to capture a second image of the surface based on reflected light that originates from the one or more second sets of LEDs.
FILED Tuesday, April 23, 2019
APPL NO 17/047465
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0075 (20130101)
A61B 5/444 (20130101) Original (OR) Class

Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/108 (20130101)
G01J 3/0208 (20130101)
G01J 3/2823 (20130101)
G01J 2003/104 (20130101)
G01J 2003/2826 (20130101)

Pictorial Communication, e.g Television
H04N 23/11 (20230101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161663 Peviani et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
APPLICANT(S) Children's Medical Center Corporation (Boston, Massachusetts);  Politecnico di Milano (Milan, Italy);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Children's Medical Center Corporation (Boston, Massachusetts);  Politecnico di Milano (Milan, Italy);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Marco Peviani (Boston, Massachusetts);  Alessandra Biffi (Boston, Massachusetts);  Davide Moscatelli (Milan, Italy);  Umberto Capasso Palmiero (Milan, Italy);  Renato Auriemma (Milan, Italy);  Mattia Sponchioni (Milan, Italy);  Letterio Salvatore Politi (Milan, Italy)
ABSTRACT The present invention provides compositions and methods for targeting cells for therapeutic and/or diagnostic purposes, e.g., delivery of therapeutic and/or diagnostic agents to a cell. Nanoparticles and polymers functionalized with capture molecules, reporter molecules, and/or therapeutic agents are provided for the treatment or prevention of disease, including neurological diseases associated with neuroinflammation, and cancer.
FILED Monday, September 28, 2020
APPL NO 17/035339
ART UNIT 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/145 (20130101)
A61K 31/655 (20130101)
A61K 31/662 (20130101)
A61K 31/785 (20130101) Original (OR) Class
A61K 47/58 (20170801)
A61K 47/545 (20170801)
A61K 47/6933 (20170801)
A61K 47/6935 (20170801)
A61K 49/085 (20130101)
A61K 49/128 (20130101)
A61K 49/1824 (20130101)
A61K 49/1854 (20130101)
A61K 51/065 (20130101)
A61K 51/1244 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 290/061 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161832 Zeira et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Aberdeen Proving Ground (APG)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) DEKA Products Limited Partnership (Manchester, New Hampshire)
ASSIGNEE(S) DEKA Products Limited Partnership (Manchester, New Hampshire)
INVENTOR(S) Eitan C. Zeira (Hollis, New Hampshire);  Jason A. Demers (Manchester, New Hampshire);  Dean Kamen (Bedford, New Hampshire)
ABSTRACT A medical agent delivery device may comprise a collapsible reservoir and a base portion including at least one microneedle on a first face and on an opposing second face. Each microneedle on the first face may fluidically communicate with a microneedle on the second face. The device may further comprise an elastomeric housing attached to the first face. The reservoir and the at least one microneedle on the first face of the base portion may be within the elastomeric housing. The device may further comprise a displaceable spacer having a first position in which the spacer supports the reservoir in spaced relation to the at least one microneedle on the first side of the base portion. When the spacer is in a second position, the elastomeric housing may be configured to press the reservoir into the at least one microneedle on the first side of the base portion.
FILED Monday, March 01, 2021
APPL NO 17/188301
ART UNIT 3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/145 (20130101)
A61M 37/0015 (20130101) Original (OR) Class
A61M 2037/003 (20130101)
A61M 2037/0023 (20130101)
A61M 2202/0007 (20130101)
A61M 2205/36 (20130101)
A61M 2205/3368 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161889 Shusta et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Eric V. Shusta (Madison, Wisconsin);  Charles C. Stutz (Waltham, Massachusetts)
ABSTRACT The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
FILED Wednesday, July 24, 2019
APPL NO 17/260697
ART UNIT 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)

Peptides
C07K 16/28 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162035 Chang et al.
FUNDED BY
Department of Defense (DOD)
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Chih-hung Chang (Corvallis, Oregon);  Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon);  Yujuan He (Corvallis, Oregon);  Jeffrey Dhas (Corvallis, Oregon);  Brian K. Paul (Corvallis, Oregon);  Somayeh Pasebani (Corvallis, Oregon);  Chuankai Song (Corvallis, Oregon);  Sakineh Abbasi (Corvallis, Oregon)
ABSTRACT A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces.
FILED Tuesday, July 26, 2022
APPL NO 17/814914
ART UNIT 1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 1/28 (20130101)
B05B 7/0075 (20130101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/12 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162575 Ouyang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida)
ASSIGNEE(S) Florida Atlantic University Board of Trustees (Boca Raton, Florida)
INVENTOR(S) Bing Ouyang (Fort Pierce, Florida);  Tsung-Chow Su (Boca Raton, Florida);  Yanjun Li (Fort Pierce, Florida);  Jordan Thomas (Boca Raton, Florida)
ABSTRACT Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion.
FILED Friday, April 09, 2021
APPL NO 17/226913
ART UNIT 3678 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/106 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects
B63C 11/52 (20130101) Original (OR) Class

Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers
B63G 8/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162576 Seeley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
ASSIGNEE(S) The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
INVENTOR(S) Eric Seeley (Seebeck, Washington);  Jacob Snow (Bremerton, Washington)
ABSTRACT A system for joining mass-controlling modules comprising modular elements and attachable components, including a male end adapted to join a single-piece female end by rotating the male end into the single-piece female end such that data bus terminals align and power bus terminals align. The system can be assembled from these modular elements and components to meet desired mission and performance characteristics without the need to purchase specially designed systems for each mission. The joints connecting the modules are designed such that power and data connections between modules are reliably made.
FILED Wednesday, July 19, 2023
APPL NO 18/224037
ART UNIT 2831 — Electrical Circuits and Systems
CURRENT CPC
Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers
B63G 8/001 (20130101)
B63G 8/04 (20130101) Original (OR) Class
B63G 2008/002 (20130101)

Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 12/91 (20130101)
H01R 12/7005 (20130101)
H01R 13/64 (20130101)
H01R 13/641 (20130101)
H01R 13/6205 (20130101)
H01R 13/7175 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162577 Seeley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
ASSIGNEE(S) The United States of America as represented by the Secretary of the Navy (Keyport, Washington)
INVENTOR(S) Eric Seeley (Seebeck, Washington);  Jacob Snow (Bremerton, Washington)
ABSTRACT A system for joining buoyancy-controlling modules comprising modular elements and attachable components, including a male end adapted to join a single-piece female end by rotating the male end into the single-piece female end such that data bus terminals align and power bus terminals align. The system can be assembled from these modular elements and components to meet desired mission and performance characteristics without the need to purchase specially designed systems for each mission. The joints connecting the modules are designed such that power and data connections between modules are reliably made.
FILED Wednesday, July 19, 2023
APPL NO 18/224040
ART UNIT 2831 — Electrical Circuits and Systems
CURRENT CPC
Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers
B63G 8/001 (20130101)
B63G 8/04 (20130101) Original (OR) Class
B63G 2008/002 (20130101)

Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 12/91 (20130101)
H01R 12/7005 (20130101)
H01R 13/64 (20130101)
H01R 13/641 (20130101)
H01R 13/6205 (20130101)
H01R 13/7175 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162910 Franchini et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  New York University (New York, New York)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  New York University (New York, New York)
INVENTOR(S) Genoveffa Franchini (Washington, District of Columbia);  Timothy Cardozo (New York, New York);  Manuel Becerra-Flores (Brooklyn, New York);  Isabela Silva de Castro (Bethesda, Maryland);  Giacomo Gorini (Bethesda, Maryland);  Massimiliano Bissa (Washington, District of Columbia)
ABSTRACT Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
FILED Monday, October 21, 2019
APPL NO 17/285453
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 39/21 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Peptides
C07K 14/162 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56988 (20130101)
G01N 2333/16 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162925 Weiner et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
APPLICANT(S) The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
INVENTOR(S) David Weiner (Merion, Pennsylvania);  Ami Patel (Philadelphia, Pennsylvania)
ABSTRACT Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.
FILED Monday, September 17, 2018
APPL NO 16/647082
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 2317/10 (20130101)
C07K 2317/21 (20130101)
C07K 2317/24 (20130101)
C07K 2317/76 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2760/14111 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163130 Schaefer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Breast Cancer Research Program (USAMRMCBCRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Icahn School of Medicine at Mount Sinai (New York, New York);  The Rockefeller University (New York, New York)
ASSIGNEE(S) Icahn School of Medicine at Mount Sinai (New York, New York);  The Rockefeller University (New York, New York)
INVENTOR(S) Anne Schaefer (New York, New York);  Paul Greengard (New York, New York);  Chan Lek Tan (San Francisco, California)
ABSTRACT The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
FILED Monday, November 16, 2020
APPL NO 17/099209
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 67/0276 (20130101)
A01K 2217/052 (20130101)
A01K 2217/075 (20130101)
A01K 2217/203 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0356 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/185 (20130101)
A61K 49/0008 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
A61P 25/08 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
C12N 2310/315 (20130101)
C12N 2310/321 (20130101)
C12N 2310/321 (20130101)
C12N 2310/341 (20130101)
C12N 2310/346 (20130101)
C12N 2310/3515 (20130101)
C12N 2310/3521 (20130101)
C12N 2310/3521 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5058 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163442 Holleran
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Aeronautical Systems Center (ASC)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Evendale, Ohio)
INVENTOR(S) Mark Anthony Holleran (Cincinnati, Ohio)
ABSTRACT A shroud assembly is provided for a gas turbine engine defining an axial direction, a radial direction, and a circumferential direction. The shroud assembly includes: a shroud segment extending substantially along the circumferential direction and including a shroud wall, the shroud wall defining a shroud attachment opening; a hanger assembly including a hanger wall defining a hanger attachment opening; and an attachment pin assembly including a first member defining an interference fit with the hanger wall through the hanger attachment opening and including a shoulder contacting the hanger wall, the first member further extending through the shroud attachment opening and defining a hollow core; and a second member extending through the hollow core of the first member, the second member extending between a first end and a second end, the second member including a rim at the first end and a secondary attachment member at the second end.
FILED Tuesday, September 12, 2023
APPL NO 18/465514
ART UNIT 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 11/08 (20130101)
F01D 25/005 (20130101)
F01D 25/28 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/11 (20130101)
F05D 2260/36 (20130101)
F05D 2300/6033 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163444 Neely et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Jared Neely (Troy, Ohio);  James Joo (Centerville, Ohio);  Russel Topp (Dayton, Ohio)
ABSTRACT A morphing airfoil includes a dynamic flexible skin system that is capable of carrying high level aerodynamic (or fluid) pressure loads over a structural surface. The structural surface can morph and bend in response to control inputs to change a lift force without separate movable control surfaces. A plurality of standoff mounts are attached to an inner surface of anisotropic skin. The standoff mounts include through apertures for receiving a flexible stringer. The anisotropic skin is attached to underlying structure through the flexible stringers. The flexible stringers interface with actuated position control ribs and passive compliant support ribs. A control system causes the underlying support structure to move to a desired location which in turn causes the skin to bend and/or flex without exceeding a stress threshold and thus vary the lift and drag distributions along a span of the airfoil without separate control surfaces.
FILED Wednesday, October 25, 2023
APPL NO 18/383506
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Aeroplanes; Helicopters
B64C 3/26 (20130101)
B64C 3/48 (20130101)
B64C 2003/445 (20130101)

Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/141 (20130101)
F01D 5/147 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2250/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163484 Sperry
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Cummins Inc. (Columbus, Indiana)
ASSIGNEE(S) Cummins Inc. (Columbus, Indiana)
INVENTOR(S) Robert G. Sperry (Columbus, Indiana)
ABSTRACT A piston can include a skirt, a crown, and a cooling gallery. The skirt can have an upper body portion. The crown can be formed at the upper body portion. A wall can be formed underneath the crown so as to define a cooling gallery within the piston. The cooling gallery includes cooling gallery peripheral portion and a cooling gallery central portion. The cooling gallery can be configured to receive and to retain an amount of cooling fluid and to cause movement thereof within the cooling gallery between a cooling gallery peripheral portion and a cooling gallery central portion as the piston travels between top dead center and bottom dead center so as to cool both the piston outer region and the piston center region.
FILED Friday, December 03, 2021
APPL NO 18/265154
ART UNIT 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines
F02F 3/22 (20130101) Original (OR) Class
F02F 3/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163496 Son et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for STEM Education (EDU)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Steven Forrest Son (West Lafayette, Indiana);  Kyle Uhlenhake (Lafayette, Indiana);  Diane Collard (West Lafayette, Indiana);  Mateo Gomez (West Lafayette, Indiana)
ABSTRACT An igniter system and method for igniting a propellant by an optical energy source. The igniter system including an igniter composite and a propellant. The igniter composite including a reactive component and a fluoropolymer. The propellant is coupled to the igniter composite. The igniter composite has a composition including nano-aluminum at ideal stoichiometry in polyvinylidene fluoride. The igniter composite is configured to achieve a sustained ignition from a wavelength emitted from the optical energy source. The wavelength is between around 250 nanometers to around 1100 nanometers.
FILED Friday, December 01, 2023
APPL NO 18/527230
ART UNIT 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Jet-propulsion Plants
F02K 9/95 (20130101)

Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines
F02P 23/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163773 Nguyen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
Naval Air Warfare Center Aircraft Division (NAWCAD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) iSenseCloud, Inc. (Milpitas, California)
ASSIGNEE(S) iSenseCloud, Inc. (San Jose, California)
INVENTOR(S) An-Dien Nguyen (Fremont, California);  An H. Nguyen (Fremont, California)
ABSTRACT A fiber optic voltage conditioner, and method therefor, generally relate to voltage conditioning. In such a fiber optic voltage conditioner, there is a laser, and an optical circulator is coupled to receive a light signal from the laser. A controller is coupled to the laser and is configured to generate first control information for wavelength-drift control of the laser. A data acquisition module is coupled to the controller and is configured to generate second control information for the controller for adjustment of the first control information. A photodetector is coupled to the optical circulator to receive a returned optical signal and is coupled to the data acquisition module to provide an analog output signal thereto. The photodetector is configured to generate the analog output signal responsive to the returned optical signal. The data acquisition module is configured to generate the second control information using the analog output signal.
FILED Friday, July 01, 2022
APPL NO 17/856914
ART UNIT 2828 — Semiconductors/Memory
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 11/165 (20130101) Original (OR) Class

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/3206 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 5/0612 (20130101)
H01S 5/0617 (20130101)
H01S 5/0622 (20130101)
H01S 5/0687 (20130101)
H01S 5/02415 (20130101)
H01S 5/4087 (20130101)
H01S 5/06804 (20130101)
H01S 5/06808 (20130101)
H01S 5/06837 (20130101)

Transmission
H04B 10/572 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163844 Rhee et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) RAYTHEON COMPANY (Waltham, Massachusetts)
ASSIGNEE(S) RAYTHEON COMPANY (Waltham, Massachusetts)
INVENTOR(S) Jehyuk Rhee (Newbury Park, California);  Matthew C. Thomas (Carpinteria, California);  Henry Lee (Goleta, California)
ABSTRACT A LADOR circuit is in signal communication with a pixel array. The LADOR circuit is configured to generate an integrator reset voltage based on a resistance of the at least one heated bolometer pixel, and to detect laser energy incident on the at least one heated bolometer pixel based on a comparison between the integrator reset voltage and an input threshold voltage (Vthreshold).
FILED Wednesday, November 10, 2021
APPL NO 17/523391
ART UNIT 2884 — Optics
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/24 (20130101) Original (OR) Class
G01J 5/048 (20130101)
G01J 2005/0077 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163953 Whitten et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S) STC.UNM (Albuquerque, New Mexico)
INVENTOR(S) David G. Whitten (Albuquerque, New Mexico);  Harry Craig Pappas (Albuquerque, New Mexico);  Eric H. Hill (Donostia, Spain);  Yue Zhang (Albuquerque, New Mexico);  Eva Yung Hua Chi (Albuquerque, New Mexico);  Arjun Thapa (Oklahoma City, Oklahoma);  Ying Wang (Albuquerque, New Mexico);  Patrick L Donabedian (Albuquerque, New Mexico);  Kiran Bhaskar (Albuquerque, New Mexico)
ABSTRACT Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
FILED Monday, December 09, 2019
APPL NO 16/707501
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Peptides
C07K 14/65 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/02 (20130101)
C08G 2261/94 (20130101)
C08G 2261/312 (20130101)
C08G 2261/3328 (20130101)
C08G 2261/3422 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/44 (20130101)
C12Q 1/46 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/52 (20130101) Original (OR) Class
G01N 2333/916 (20130101)
G01N 2333/918 (20130101)
G01N 2800/2828 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164020 Bayer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Mustafa Mert Bayer (Irvine, California);  Ozdal Boyraz (Irvine, California)
ABSTRACT Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones.
FILED Friday, September 03, 2021
APPL NO 17/467012
ART UNIT 2877 — Optics
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/584 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164066 Ma et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Biwu Ma (Tallahassee, Florida);  Liang-Jin Xu (Tallahassee, Florida);  Qingquan He (Tallahassee, Florida)
ABSTRACT Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.
FILED Friday, March 12, 2021
APPL NO 17/909611
ART UNIT 2884 — Optics
CURRENT CPC
Measurement of Nuclear or X-radiation
G01T 1/2002 (20130101)
G01T 1/2018 (20130101)
G01T 1/2023 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164097 Kolle et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Mathias Kolle (Hull, Massachusetts);  Cecile Chazot (Cambridge, Massachusetts)
ABSTRACT Articles and systems for dark microscopy and related methods are generally described.
FILED Wednesday, December 23, 2020
APPL NO 17/133159
ART UNIT 2872 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/08 (20130101)
G02B 5/09 (20130101)
G02B 5/0825 (20130101)
G02B 17/0673 (20130101)
G02B 21/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164631 Heynssens et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona)
INVENTOR(S) Julie B. Heynssens (Flagstaff, Arizona);  Bertrand F. Cambou (Flagstaff, Arizona)
ABSTRACT An arrangement and method for detecting number splitting attacks in quantum key distribution systems is disclosed. According to the method, a receiver may detect the presence of an eavesdropper on a transmission channel by detecting an increase in the percent difference between the photon transmission rates of two signals of different wavelengths. The receiver may directly measure a percent difference in photon receive rates as between the two signals, and compare the measured difference with an expected difference. The expected difference may be known, or may be measured by the receiver on the basis of historical data. The expected difference may be computed from the percent difference between the means of the Poisson distributions of the transmitter's laser sources, which may be determined a priori and communicated to the transmitter.
FILED Wednesday, December 07, 2022
APPL NO 18/077169
ART UNIT 2445 — Computer Networks
CURRENT CPC
Electric Digital Data Processing
G06F 21/554 (20130101) Original (OR) Class
G06F 2221/034 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/0852 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164688 Dekleva et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Space and Naval Warfare Systems Center (SPAWAR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S) Brian Dekleva (Pittsburgh, Pennsylvania);  Jennifer Lynn Collinger (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein are methods and systems for transient-based decoding of neural signals. In one aspect, a device such as a brain-computer interface (BCI), includes at least one processor configured to receive a plurality of neural signals from a subject. The at least one processor can detect, from the plurality of neural signals, first neural activity unique to a first defined temporal window corresponding to an onset phase of an intended action of the subject. The at least one processor can detect, from the plurality of neural signals, second neural activity unique to a second defined temporal window, occurring after the first temporal window and corresponding to an offset phase of the intended action. The at least one processor can generate at least one output indicative of the intended action, responsive to detecting at least one of the first neural activity or the second neural activity.
FILED Wednesday, September 07, 2022
APPL NO 17/939893
ART UNIT 2625 — Selective Visual Display Systems
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/372 (20210101)

Electric Digital Data Processing
G06F 3/015 (20130101) Original (OR) Class
G06F 3/0484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165004 Pichler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Hannes Pichler (Cambridge, Massachusetts);  Shengtao Wang (Somerville, Massachusetts);  Leo Xiangyu Zhou (Somerville, Massachusetts);  Soonwon Choi (El Cerrito, California);  Mikhail D. Lukin (Cambridge, Massachusetts)
ABSTRACT Systems and methods relate to selectively arranging a plurality of qubits into a spatial structure to encode a quantum computing problem. Exemplary arrangement techniques can be applied to encode various quantum computing problems. The plurality of qubits can be driven according to various driving techniques into a final state. The final state can be measured to identify an exact or approximate solution to the quantum computing problem.
FILED Friday, August 30, 2019
APPL NO 17/270741
ART UNIT 2182 — Computer Architecture and I/O
CURRENT CPC
Optical Computing Devices;
G06E 1/00 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
G06N 10/40 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165068 Savvides et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Marios Savvides (Pittsburgh, Pennsylvania);  Dipan Kumar Pal (Pittsburgh, Pennsylvania);  Yutong Zheng (Pittsburgh, Pennsylvania)
ABSTRACT A method of training a deep neural network, such as would be used in facial recognition, includes training the deep neural network to normalize feature vectors to a learned value representing the radius of a multi-dimensional hypersphere using a convex augmentation of the primary loss function.
FILED Thursday, February 28, 2019
APPL NO 16/968040
ART UNIT 2125 — AI & Simulation/Modeling
CURRENT CPC
Electric Digital Data Processing
G06F 17/16 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/084 (20130101) Original (OR) Class

Image or Video Recognition or Understanding
G06V 40/168 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165779 Houten et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Spark Thermionics, Inc. (Berkeley, California)
ASSIGNEE(S) Spark Thermionics, Inc. (Berkeley, California)
INVENTOR(S) Kyana Van Houten (Berkeley, California);  Lucas Heinrich Hess (Berkeley, California);  Jared William Schwede (Berkeley, California);  Felix Schmitt (Berkeley, California)
ABSTRACT A thermionic energy conversion system, preferably including one or more electron collectors, interfacial layers, encapsulation, and/or electron emitters. A method for manufacturing the thermionic energy conversion system. A method of operation for a thermionic energy conversion system, preferably including receiving power, emitting electrons, and receiving the emitted electrons, and optionally including convectively transferring heat.
FILED Friday, January 12, 2024
APPL NO 18/412030
ART UNIT 2818 — Semiconductors/Memory
CURRENT CPC
Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation
G21H 1/106 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 45/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165826 Foshage
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
United States Marine Corps (USMC)
APPLICANT(S) RCT Systems, Inc. (Baltimore, Maryland)
ASSIGNEE(S) RCT SYSTEMS, INC. (Baltimore, Maryland)
INVENTOR(S) Gerald K. Foshage (Boxford, Massachusetts)
ABSTRACT A non-cryogenic electro-permanent magnet for use in a gyrotron comprises a plurality of toroidal-shaped sets of electromagnet coils and a plurality of toroidal-shaped permanent magnets, each permanent magnet comprising a plurality of arc segment blocks. Each set of the coils is separated from an adjacent set of the coils by one or more of the permanent magnets disposed between the adjacent sets of coils, such that the coils and the permanent magnets are arranged concentrically to form an open central bore. A combination of magnetic fields in the permanent magnets and magnetic fields in the coils generates a substantially uniform axial magnetic field in the bore.
FILED Monday, November 09, 2020
APPL NO 17/092814
ART UNIT 2837 — Electrical Circuits and Systems
CURRENT CPC
Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 7/0278 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 25/025 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166198 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Navitas Systems, LLC (Ann Arbor, Michigan)
ASSIGNEE(S) Navitas Systems, LLC (Ann Arbor, Michigan)
INVENTOR(S) Pu Zhang (Ann Arbor, Michigan);  Michael Wixom (Ann Arbor, Michigan);  Robert Sosik (Ann Arbor, Michigan)
ABSTRACT Provided are electrodes that include an electrode dry mixture and a dry electrolyte material intermixed with the electrode dry mixture; and a binder intermixed with the electrode dry mixture and the dry electrolyte material, said binder comprising fibrils; the electrode dry mixture, dry electrolyte material, and said binder in the form of a dry electrode film. The electrolyte material may include a glass ceramic and, optionally, an air-stabilizing dopant. The glass ceramic may include Li3PS4. The electrodes may include a composite cathode of the dry electrode film and optionally further include a solid-state electrolyte layer. Also provided are methods for forming the electrodes, optionally where the methods may be applicable for a solvent-free process to form electrodes and electrochemical cells and batteries including the electrodes.
FILED Wednesday, November 29, 2023
APPL NO 18/523159
ART UNIT 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/043 (20130101)
H01M 4/134 (20130101)
H01M 4/366 (20130101)
H01M 4/382 (20130101)
H01M 4/628 (20130101)
H01M 4/1395 (20130101) Original (OR) Class
H01M 10/052 (20130101)
H01M 10/0562 (20130101)
H01M 2300/0068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166247 Patrissi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S) The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S) Charles J Patrissi (Newport, Rhode Island);  Jennifer R Rizzo (Portsmouth, Rhode Island);  Christian R Schumacher (Newport, Rhode Island)
ABSTRACT A method is provided for making a ceramic lithium ion conducting membrane and for making an anode pouch for a lithium-seawater battery. The method for making the ceramic membrane includes adding pore formers into a liquid slurry of LTAP (Li2O—Al2O3—SiO2—P2O5—TiO2) powder. The liquid slurry is converted into porous green tape and the porous green tape is laminated onto the top of nonporous green tapes to form a stack. The stack is sintered and the pore formers are decomposed to create pores in the top layer of the ceramic membrane. The porous ceramic membrane is used to create a more robust hermetic seal in an anode pouch for the battery compared to a seal made with a nonporous ceramic membrane.
FILED Thursday, September 30, 2021
APPL NO 17/489946
ART UNIT 1728 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/76 (20130101)
H01M 6/02 (20130101) Original (OR) Class
H01M 6/34 (20130101)
H01M 6/187 (20130101)
H01M 6/188 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166476 Sharma et al.
FUNDED BY
Department of Defense (DOD)
Defense MicroElectronics Activity (DMEA)
APPLICANT(S) GlobalFoundries U.S. Inc. (Malta, New York)
ASSIGNEE(S) GlobalFoundries U.S. Inc. (Malta, New York)
INVENTOR(S) Santosh Sharma (Austin, Texas);  Johnatan Avraham Kantarovsky (South Burlington, Vermont);  Rajendran Krishnasamy (Essex Junction, Vermont)
ABSTRACT An integrated circuit (IC) having a high voltage semiconductor device with a plurality of field plates between the gate and drain. The IC further includes a biasing circuit electrically coupled to each of the plurality of field plates, the biasing circuit including a plurality of high voltage depletion mode transistors, each having a pinch off voltage. The high voltage depletion mode transistors may have different pinch off voltages, and each of the field plates are each independently biased by a different one of the high voltage depletion mode transistors.
FILED Wednesday, December 14, 2022
APPL NO 18/065768
ART UNIT 2842 — Electrical Circuits and Systems
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/404 (20130101)
H01L 29/7816 (20130101)

Pulse Technique
H03K 17/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166516 Rachid
FUNDED BY
Department of Defense (DOD)
United States Special Operations Command (SOCOM)
APPLICANT(S) SILVUS TECHNOLOGIES, INC. (Los Angeles, California)
ASSIGNEE(S) SILVUS TECHNOLOGIES, INC. (Los Angeles, California)
INVENTOR(S) Mansour Rachid (Los Angeles, California)
ABSTRACT Certain disclosed embodiments pertain to suppressing interference in a wireless communication system. For example, a method of suppressing interference can include receiving one, two, or more first signals including components from a plurality of sub-channels. Each of the first signals can be processed by a Finite Impulse Response filter adapted using an LMS update algorithm.
FILED Thursday, April 07, 2022
APPL NO 17/658415
ART UNIT 2641 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC
Transmission
H04B 1/0057 (20130101)
H04B 1/0078 (20130101)
H04B 1/0483 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166623 Wang et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Yang Wang (Boulder, Colorado);  Yu T. Morton (Boulder, Colorado)
ABSTRACT DLOS and reflected signal components of an RF carrier signal are received. The reflected component is reflected from a point on the surface of the earth. The DLOS and reflected components are converted to digital DLOS IF and reflected IF signals, respectively. Modeled parameters are generated using the digital DLOS IF signal and locations of one or more antennas, the transmitter, and the point. A reference signal is generated based on the modeled parameters. The reference signal is correlated with the digital reflected IF signal to produce in-phase and quadrature-phase correlation results. A C/N0 and an estimated phase (EP) are calculated for the digital reflected IF signal from the correlation results. A KF is applied to the EP to produce an estimated filter phase (EFP). The KF is adapted to filter the EP using the estimated C/N0 to reduce cycle slips and noise in the EFP.
FILED Monday, October 18, 2021
APPL NO 18/249580
ART UNIT 2633 — Digital Communications
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 27/0014 (20130101)
H04L 27/3863 (20130101) Original (OR) Class
H04L 2027/0067 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 12161894 Barrick et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Todd Andrew Barrick (Bosque Farms, New Mexico);  Eric A. Shaner (Rio Rancho, New Mexico);  Bradley Salzbrenner (Albuquerque, New Mexico);  Michael Alexis Omana (Edgewood, New Mexico);  Thomas John Rogers (Albuquerque, New Mexico);  Dora K. Wiemann (Albuquerque, New Mexico);  Lorenzo Jiron (Sandia Park, New Mexico)
ABSTRACT A test fixture facilitates non-destructive testing of a protective mask. The test fixture includes a mock facial structure, a clamping form that makes a seal around at least part of the facial structure, and can employ the retaining straps of the protective mask to a make a seal around at least part of the facial structure. In use, the protective mask is tested in situ on the facial structure. In some examples, the clamping form has a negative contour of the mock facial structure or of the outer surface of a protective mask that is to be tested. The testing can include repetitive testing of the fit, structural components (e.g., ultrasonic welds and straps), and the degradation of materials as a function of donning/doffing or environmental factors (e.g., temperature and humidity).
FILED Wednesday, September 28, 2022
APPL NO 17/955383
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Devices, Apparatus or Methods for Life-saving
A62B 27/00 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/0806 (20130101)
G01N 2015/084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161972 Sant et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Gaurav Sant (Los Angeles, California);  Erika Callagon La Plante (Los Angeles, California);  Jingbo Wang (Los Angeles, California);  David Jassby (Los Angeles, California);  Dante Simonetti (Los Angeles, California);  Abdulaziz Alturki (Los Angeles, California);  Xin Chen (Los Angeles, California)
ABSTRACT Provided herein are methods of removing carbon dioxide from an aqueous stream or gaseous stream by: contacting the gaseous stream comprising carbon dioxide, when present, with an aqueous solution comprising ions capable of forming an insoluble carbonate salt; contacting the aqueous solution comprising carbon dioxide with an electroactive mesh that induces its alkalinization thereby forcing the precipitation of a carbonate solid from the solution and thereby the removal of dissolved inorganic carbon by electrolysis; and removing the precipitated carbonate solids from the solution, or the surface of the mesh where they may deposit. Also provided herein are flow-through electrolytic reactors comprising an intake device in fluid connection with a rotating cylinder comprising an electroactive mesh, and a scraping device and/or liquid-spray based device for separating a solid from the mesh surface.
FILED Tuesday, July 26, 2022
APPL NO 17/873953
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Separation
B01D 53/62 (20130101)
B01D 53/78 (20130101)
B01D 53/965 (20130101) Original (OR) Class
B01D 2251/402 (20130101)
B01D 2251/404 (20130101)
B01D 2252/1035 (20130101)
B01D 2257/504 (20130101)
B01D 2258/06 (20130101)
B01D 2258/025 (20130101)
B01D 2258/0233 (20130101)
B01D 2258/0283 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 13/36 (20130101)
C01B 32/60 (20170801)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4618 (20130101)
C02F 1/46109 (20130101)
C02F 2001/4619 (20130101)
C02F 2001/46133 (20130101)
C02F 2001/46161 (20130101)
C02F 2001/46171 (20130101)
C02F 2103/08 (20130101)
C02F 2103/18 (20130101)
C02F 2201/4618 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12161996 Gao et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S) UNIVERSITY OF CONNECTICUT (Farmington, Connecticut)
INVENTOR(S) Pu-Xian Gao (Coventry, Connecticut);  Son Hoang (Corona, New York)
ABSTRACT Metal oxide nanoarrays, such as titanium oxide nanoarrays, having a platinum group metal dispersed thereon and methods of making such nanoarrays are described. The platinum group metal can be dispersed on the metal oxide nanoarray as single atoms. The nanoarrays can be used to catalyze oxidation of combustion exhaust.
FILED Thursday, May 04, 2023
APPL NO 18/143559
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Separation
B01D 53/865 (20130101)
B01D 2255/1021 (20130101)
B01D 2255/20707 (20130101)
B01D 2258/012 (20130101)
B01D 2259/4566 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/063 (20130101) Original (OR) Class
B01J 23/42 (20130101)
B01J 35/19 (20240101)
B01J 35/23 (20240101)
B01J 35/40 (20240101)
B01J 35/56 (20240101)
B01J 35/58 (20240101)
B01J 37/10 (20130101)
B01J 37/0217 (20130101)
B01J 37/344 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162035 Chang et al.
FUNDED BY
Department of Defense (DOD)
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Chih-hung Chang (Corvallis, Oregon);  Venkata Vinay Krishna Doddapaneni (Corvallis, Oregon);  Yujuan He (Corvallis, Oregon);  Jeffrey Dhas (Corvallis, Oregon);  Brian K. Paul (Corvallis, Oregon);  Somayeh Pasebani (Corvallis, Oregon);  Chuankai Song (Corvallis, Oregon);  Sakineh Abbasi (Corvallis, Oregon)
ABSTRACT A print head comprising nested chambers for in-situ reactant formation is disclosed. The print head comprises a first chamber nested within a second chamber. The first chamber comprises a first nozzle, the second chamber comprises a second nozzle. The first nozzle is substantially coaxial with the second nozzle. A susceptor to convert electromagnetic energy to heat is within the first chamber. The susceptor comprises one or more openings extending between the upper portion and the lower portion. The susceptor may be heated by induction heating or by optical heating to vaporize a precursor substance within the first chamber. The vapor may react with a reactive gas flowing through the first chamber or expand through a nozzle into a second chamber where the vapor may react with the reactive gas, forming nanoparticles. Patterned films may be written onto a two-dimensional or three-dimensional surfaces.
FILED Tuesday, July 26, 2022
APPL NO 17/814914
ART UNIT 1717 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 1/28 (20130101)
B05B 7/0075 (20130101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/12 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162074 Khairallah et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Seurat Technologies, Inc. (Wilmington, Massachusetts)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California);  Seurat Technologies, Inc. (Wilmington, Massachusetts)
INVENTOR(S) Saad A. Khairallah (Livermore, California);  John Roehling (Livermore, California);  Yiyu Shen (Tewksbury, Massachusetts);  Andrew James Bayramian (Marblehead, Massachusetts);  Ning Duanmu (Nashua, New Hampshire);  James A. Demuth (Woburn, Massachusetts)
ABSTRACT The present disclosure relates to systems and methods for performing large area laser powder bed fusion (LBPF) to form a plurality of layers of a 3D part in a layer-by-layer fashion using meltable powder particles. In one implementation the system makes use of a first light source, which may be a diode laser subsystem, for generating a first light pulse of a first duration. The first light is used to preheat a substrate underneath a new layer of powder particles, wherein the substrate is formed from a previously fused quantity of the powder particles. A second light source, which may be a pulse laser, generates a second light pulse subsequent to the first light pulse. The second light pulse has a second duration shorter than the first duration by a factor of at least about 10, and fully melts the new layer of powder particles in addition to the substrate, to achieve a smooth printed layer. The wavelength of the first light pulse also differs from a wavelength of the second light pulse.
FILED Monday, October 04, 2021
APPL NO 17/492832
ART UNIT 3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 10/28 (20210101)
B22F 12/43 (20210101) Original (OR) Class

Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/342 (20151001)
B23K 26/0608 (20130101)
B23K 26/0622 (20151001)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162369 Hafiz et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Hitachi Energy Ltd (Zürich, Switzerland)
ASSIGNEE(S) HITACHI ENERGY LTD (Zürich, Switzerland)
INVENTOR(S) Faeza Hafiz (Raleigh, North Carolina);  Dmitry Ishchenko (Cary, North Carolina)
ABSTRACT Network constraint energy management system for electric vehicle (EV) depot charging and scheduling. In an embodiment, a power schedule is received from an economic dispatch application for a charging depot comprising EV charging station(s) and distributed energy resource(s). The power schedule may be simulated on a distribution network model of the charging depot, according to load flow analysis, to determine whether any grid-code violations occur. In response to the detection of violation(s), a constraint may be generated for each violating node, and the economic dispatch application may be re-executed with the constraint(s) to produce a new power schedule, until no violations are detected. When not all load demand can be satisfied by the power schedule, a charging schedule may be adjusted to ensure that critical energy requirements are satisfied. The final power and charging schedules may be used to schedule and control power generation and charging in the charging depot.
FILED Wednesday, December 15, 2021
APPL NO 17/551502
ART UNIT 3663 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles
B60L 53/63 (20190201)
B60L 53/64 (20190201) Original (OR) Class
B60L 53/65 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162629 Cooley et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
National High Magnetic Field Laboratory (NHMFL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Lance D. Cooley (Tallahassee, Florida);  Christian M. Hubicki (Tallahassee, Florida)
ABSTRACT Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module.
FILED Tuesday, November 22, 2022
APPL NO 17/992588
ART UNIT 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/002 (20130101) Original (OR) Class

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/02 (20130101)
H01F 6/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162980 Rogers et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Verdox, Inc. (Woburn, Massachusetts)
ASSIGNEE(S) Verdox, Inc. (Woburn, Massachusetts)
INVENTOR(S) Cameron Rogers (Malden, Massachusetts);  Sahag Voskian (Boston, Massachusetts)
ABSTRACT A quinone-containing poly(arylene) includes repeating units of formula (I), (II), (III), (IV), (V), or (VI) as defined herein. The quinone-containing poly(arylene) can be useful in composites, electrode assemblies, electrochemical cells, gas separation systems, energy storage devices, and electrochromic devices.
FILED Wednesday, July 26, 2023
APPL NO 18/226295
ART UNIT 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Separation
B01D 53/02 (20130101)
B01D 53/326 (20130101)
B01D 2253/202 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/121 (20130101) Original (OR) Class
C08G 2261/12 (20130101)
C08G 2261/314 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163030 Naskar et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Amit K. Naskar (Knoxville, Tennessee);  Christopher C. Bowland (Knoxville, Tennessee)
ABSTRACT A polymer blend material comprising: (i) a lignin component; (ii) a nitrile butadiene rubber component; and (iii) divalent or trivalent metal salt; wherein: component (i) is present in an amount of about 5 wt. % to about 95 wt. % by weight of components (i) and (ii); component (i) is dispersed in component (ii) in the form of domains having a size of up to 1000 nm; component (iii) is present in an amount of 0.1-10 wt. % by weight of components (i) and (ii); and the polymer blend material has a tensile failure strength of at least 10 MPa, and an elongation at break of at least 20%. Methods for producing the polymer blend, molded forms thereof, and articles thereof, are also described.
FILED Wednesday, March 25, 2020
APPL NO 16/829167
ART UNIT 1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 9/02 (20130101)
C08L 97/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163052 Aytug et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Tolga Aytug (Knoxville, Tennessee);  John T. Simpson (Clinton, Tennessee)
ABSTRACT An article having a nanostructured surface and a method of making the same are described. The article can include a substrate and a nanostructured layer bonded to the substrate. The nanostructured layer can include a plurality of spaced apart nanostructured features comprising a contiguous, protrusive material and the nanostructured features can be sufficiently small that the nanostructured layer is optically transparent. A continuous layer can be adhered to a plurality of surfaces of the nanostructured features to render the plurality of surfaces of the nanostructured features both hydrophobic and oleophobic with respect to fingerprint oil comprising eccrine secretions and sebaceous secretions, thereby providing an anti-fingerprinting characteristic to the article.
FILED Monday, April 04, 2022
APPL NO 17/712939
ART UNIT 1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 17/002 (20130101)
C03C 17/02 (20130101)
C03C 17/34 (20130101)
C03C 2217/76 (20130101)
C03C 2217/425 (20130101)
C03C 2218/33 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/00 (20130101) Original (OR) Class

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/10 (20130101)
C23C 14/58 (20130101)
C23C 14/5806 (20130101)
C23C 14/5873 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/24355 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163181 Church et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Office of Science Consolidated Service Center (CSC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) George M. Church (Brookline, Massachusetts);  Kun Zhang (Brighton, Massachusetts);  Joseph Chou (Jamaica Plain, Massachusetts)
ABSTRACT Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.
FILED Wednesday, October 14, 2020
APPL NO 17/070190
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6813 (20130101) Original (OR) Class
C12Q 1/6837 (20130101)
C12Q 1/6837 (20130101)
C12Q 1/6837 (20130101)
C12Q 2535/113 (20130101)
C12Q 2535/113 (20130101)
C12Q 2535/113 (20130101)
C12Q 2537/143 (20130101)
C12Q 2537/143 (20130101)
C12Q 2537/143 (20130101)
C12Q 2565/543 (20130101)
C12Q 2565/543 (20130101)
C12Q 2565/543 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163221 Elam et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Jeffrey W. Elam (Elmhurst, Illinois);  Angel Yanguas-Gil (Naperville, Illinois);  Joseph A. Libera (Clarendon Hills, Illinois)
ABSTRACT A system and method for continuous atomic layer deposition. The system and method includes a housing, a moving bed which passes through the housing, a plurality of precursor gases and associated input ports and the amount of precursor gases, position of the input ports, and relative velocity of the moving bed and carrier gases enabling exhaustion of the precursor gases at available reaction sites.
FILED Tuesday, February 07, 2017
APPL NO 15/426789
ART UNIT 1716 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/442 (20130101)
C23C 16/545 (20130101)
C23C 16/45527 (20130101)
C23C 16/45544 (20130101) Original (OR) Class
C23C 16/45551 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/0228 (20130101)
H01L 21/31138 (20130101)
H01L 21/67069 (20130101)

Organic electric solid-state devices
H10K 30/88 (20230201)
H10K 71/00 (20230201)
H10K 71/164 (20230201)
H10K 71/811 (20230201)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/549 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 70/50 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163236 Balema et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Ames Laboratory (AL)
Federally Funded Research and Development Center (FFRDC)
Operated by Iowa State University (IASTATE) at Ames, IA
APPLICANT(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S) Viktor Balema (Ames, Iowa);  Sonal Padalkar (Ames, Iowa);  Ihor Hlova (Ames, Iowa);  Tian Lan (Fremont, California);  Oleksandr Dolotko (Kartsruhe, Germany);  Vitalij K. Pecharsky (Ames, Iowa);  Duane D. Johnson (Ames, Iowa);  Arjun K. Pathak (East Amherst, New York);  Prashant Singh (Ames, Iowa)
ABSTRACT A cathode is provided for electrolysis of water wherein the cathode material comprises a multi-principal element, transition metal dichalcogenide material that has four or more chemical elements and that is a single phase, solid solution. The pristine cathode material does not contain platinum as a principal (major) component. However, a cathode comprising a transition metal dichalcogenide having platinum (Pt) nanosized islands or precipitates disposed thereon is also provided.
FILED Thursday, January 12, 2023
APPL NO 17/803894
ART UNIT 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 18/42 (20130101)
C23C 18/1639 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/04 (20130101)
C25B 11/051 (20210101)
C25B 11/057 (20210101)
C25B 11/075 (20210101) Original (OR) Class
C25B 11/091 (20210101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 3/50 (20130101)
C25D 5/02 (20130101)
C25D 13/02 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163470 Sobanski et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) RTX CORPORATION (Farmington, Connecticut)
INVENTOR(S) Jon E. Sobanski (Glastonbury, Connecticut);  Jacob C. Snyder (East Haddam, Connecticut)
ABSTRACT A turbine engine is provided that includes a fan section, a turbine engine core, an evaporator, a condenser, a core flowpath and a bypass flowpath. The turbine engine core is configured to power the fan section. The turbine engine core includes a core compressor section, a core combustor section and a core turbine section. The evaporator is arranged axially along an axis between the fan section and the turbine engine core. The condenser is arranged axially along the axis between the fan section and the turbine engine core. The core flowpath extends sequentially through the core compressor section, the core combustor section, the core turbine section, the evaporator and the condenser. The bypass flowpath is fluidly coupled with and downstream of the fan section. The bypass flowpath is radially outboard of and extends axially along the evaporator and the condenser.
FILED Monday, March 06, 2023
APPL NO 18/117916
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 3/22 (20130101)
F02C 3/30 (20130101)
F02C 7/141 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2260/606 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163488 Sobanski et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) RTX Corporation (Farmington, Connecticut)
ASSIGNEE(S) RTX CORPORATION (Farmington, Connecticut)
INVENTOR(S) Jon E. Sobanski (Glastonbury, Connecticut);  Neil J. Terwilliger (Cheshire, Connecticut);  Abbas A. Alahyari (Glastonbury, Connecticut)
ABSTRACT A propulsion system for an aircraft includes a propulsor rotor, an engine core, a housing, a flowpath and a heat exchange system. The engine core is configured to power rotation of the propulsor rotor. The housing includes an inner structure and an outer structure. The outer structure is radially outboard of and axially overlaps the inner structure. The flowpath is downstream of the propulsor rotor and radially between the inner structure and the outer structure. The heat exchange system includes a duct, an exterior orifice, an interior orifice, a flow regulator and a heat exchanger disposed within the duct. The exterior orifice is formed by the outer structure and disposed along an exterior of the housing. The interior orifice is formed by the outer structure and disposed along the flowpath. The flow regulator is configured to selectively fluidly couple the exterior orifice and the interior orifice to the duct.
FILED Thursday, September 07, 2023
APPL NO 18/243456
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Jet-propulsion Plants
F02K 1/32 (20130101)
F02K 1/386 (20130101)
F02K 1/822 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/323 (20130101)
F05D 2260/213 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163616 Duncan et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) GE Infrastructure Technology LLC (Greenville, South Carolina)
INVENTOR(S) Alexander Kyle Duncan (Niskayuna, New York);  Todd William Danko (Niskayuna, New York)
ABSTRACT A system for use in maintaining a structure includes a maintenance apparatus including a maintenance drive system and a maintenance device. The system includes a support apparatus configured to travel in proximity to the structure. The support apparatus includes a body including a first end and a second end and a tether support device coupled to the body. The tether support device includes a housing. The support apparatus also includes a support drive system coupled to the body. The support drive system is configured to propel the support apparatus. The system also includes a tether including a first tether end, a second tether end, and a tether body extending between the first tether end and the second tether end. The maintenance apparatus is operably coupled to the first tether end. The tether support device is coupled to the tether between the first tether end and the second tether end.
FILED Monday, January 10, 2022
APPL NO 17/572312
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General
F16L 55/30 (20130101) Original (OR) Class
F16L 55/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163663 Boardman
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) RTX CORPORATION (Farmington, Connecticut)
INVENTOR(S) Gregory Boardman (Owens Cross Roads, Alabama)
ABSTRACT An assembly is provided for a turbine engine. This assembly includes a combustor, a fuel-air mixer and a mixer guide. The combustor includes a bulkhead. The fuel-air mixer includes an inner passage, a sidewall and a fuel circuit. The inner passage extends axially along an axis within the fuel-air mixer. The sidewall extends circumferentially around and axially along the inner passage. The fuel circuit includes a first fuel passage and a first fuel nozzle outlet fluidly coupled with the first fuel passage. The first fuel passage is embedded within the sidewall and extends along the inner passage. The fuel circuit is configured to direct fuel into the inner passage through the first fuel nozzle outlet. The mixer guide couples the fuel-air mixer to the bulkhead. The mixer guide is configured to slide axially along the fuel-air mixer.
FILED Monday, April 17, 2023
APPL NO 18/135594
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/286 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163701 Ihnfeldt et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) General Engineering and Research, L.L.C. (San Diego, California);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S) General Engineering and Research LLC (San Diego, California);  The Regents of the University of California (Oakland, California)
INVENTOR(S) Robin Ihnfeldt (San Diego, California);  Renkun Chen (San Diego, California);  Sungho Jin (San Diego, California);  Tianshi Feng (La Jolla, California);  Sarath Adapa (Oakland, California)
ABSTRACT Systems and methods disclosed herein relate to a cryogenic refrigeration system which may use a compression based cryocooler or liquid nitrogen pre-cool to cool a medium to ˜80K, and may in conjunction with a magnetic refrigeration system operating in the sub-80K temperature regime to provide cooling to a medium to temperatures below 80K. In some embodiments, the disclosed system may be useful for cooling on the order of about 3 kg/day to about 300 kg/day of hydrogen gas to liquid form, with higher efficiency than a standard vapor compression based system. This higher efficiency may make the system a more attractive candidate for use in cryogenic cooling applications.
FILED Tuesday, July 28, 2020
APPL NO 17/630443
ART UNIT 3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC
Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 21/00 (20130101) Original (OR) Class
F25B 2321/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163867 Vilim et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Richard B. Vilim (Sugar Grove, Illinois);  Tat Nghia Nguyen (Willowbrook, Illinois);  Haoyu Wang (Darien, Illinois)
ABSTRACT A method for determining an optimal sensor set includes identifying a set of possible faults of a thermal hydraulic system and a set of diagnostic objectives. The method also includes obtaining descriptions of sensor sets, which includes: receiving a first description of a first sensor set, and generating, based on the first description, a second description of a second sensor set. The method further includes, for each sensor set: determining a diagnostic capability of the sensor set, and calculating a score of the particular sensor set based on the particular description and the diagnostic capability, wherein a score of a sensor set is increased by a monetary cost of the sensor set and decreased by the sensor set meeting a diagnostic objective. The method also includes identifying the optimal sensor set that has a lowest score of the sensor sets, and displaying an indication of the optimal sensor set.
FILED Tuesday, December 29, 2020
APPL NO 17/136673
ART UNIT 2858 — Printing/Measuring and Testing
CURRENT CPC
Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume
G01F 1/86 (20130101)
G01F 23/804 (20220101)

Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 99/00 (20130101) Original (OR) Class

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 23/0283 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164422 Sheridan
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S) Micron Technology, Inc. (Boise, Idaho)
INVENTOR(S) Patrick Michael Sheridan (Boulder, Colorado)
ABSTRACT Disclosed in some examples are methods, systems, memory devices, memory controllers, and machine-readable mediums which provide for reserving physical memory device resources to specific execution units. Execution units may include processes, threads, virtual machines, functions, procedures, or the like. Physical memory device resources may include channels, modules, ranks, banks, bank groups, and the like. For example, a physical memory device resource that is reservable may be a smallest unit that allows for parallel access with another of the same size unit.
FILED Friday, November 04, 2022
APPL NO 17/980919
ART UNIT 2133 — Memory Access and Control
CURRENT CPC
Electric Digital Data Processing
G06F 12/0238 (20130101)
G06F 12/0638 (20130101) Original (OR) Class
G06F 13/1668 (20130101)
G06F 2212/7201 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165365 Chambers et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Teres Technologies, Inc. (Loveland, Colorado)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California);  Teres Technologies, Inc. (Loveland, Colorado)
INVENTOR(S) David Chambers (Livermore, California);  Jeffrey Edward Mast (Loveland, Colorado)
ABSTRACT Devices, methods and techniques related to image rendering for ground-penetrating radar (GPR) systems are disclosed. In one example aspect, a method for producing one or more images associated with a GPR includes receiving information representative of signals received by the GPR, determining at least three frequency bands associated with the received information, assigning color values to the received information corresponding to the at least three frequency bands, and generating a color image for the one or more objects by combining the received information in all of the at least three frequency bands together such that the color values in the color image indicate a size of the one or more objects, a depth at which the one or more objects is buried underground, or an electrical permittivity of the one or more objects.
FILED Friday, December 30, 2022
APPL NO 18/148757
ART UNIT 2612 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/885 (20130101)

Image Data Processing or Generation, in General
G06T 3/40 (20130101)
G06T 7/90 (20170101) Original (OR) Class
G06T 2200/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165778 Wellons et al.
FUNDED BY
Department of Energy (DOE)
Office of Environmental Management (DOE-EM)
Savannah River National Laboratory (SRNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Savannah River Nuclear Solutions, LLC (SRNS) at Aiken, SC
APPLICANT(S) BATTELLE SAVANNAH RIVER ALLIANCE, LLC (Aiken, South Carolina)
ASSIGNEE(S) Battelle Savannah River Alliance, LLC (Aiken, South Carolina)
INVENTOR(S) Matthew S. Wellons (Aiken, South Carolina);  Michael A. Devore, II (North Augusta, South Carolina);  Wendy W. Kuhne (Evans, Georgia)
ABSTRACT Methods for forming particulates that are highly consistent with regard to shape, size, and content are described. Particulates are suitable for use as reference materials. Methods can incorporate actinides and/or lanthanides, e.g., uranium, and can be used for forming certified reference materials for use in the nuclear industry. Methods include formation of an aerosol from an oxalate salt solution, in-line diagnostics, and collection of particles of the aerosol either in a liquid impinger or on a solid surface.
FILED Tuesday, December 13, 2022
APPL NO 18/079923
ART UNIT 1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/06 (20130101)

Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 9/026 (20130101)
B22F 2202/06 (20130101)
B22F 2301/45 (20130101)

Production and Refining of Metals; Pretreatment of Raw Materials
C22B 60/0217 (20130101)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/46 (20130101)
C23C 24/00 (20130101)

Nuclear Reactors
G21C 3/60 (20130101) Original (OR) Class
G21C 3/623 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/12056 (20150115)
Y10T 428/12063 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12165806 Martini et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) FastCAP Systems Corporation (Wakefield, Massachusetts)
ASSIGNEE(S) FastCAP Systems Corporation (Wakefield, Massachusetts)
INVENTOR(S) Fabrizio Martini (Boston, Massachusetts);  Riccardo Signorelli (The Woodlands, Texas);  John J. Cooley (Boston, Massachusetts);  Christopher John Sibbald Deane (Boston, Massachusetts);  James Epstein (Sharon, Massachusetts);  Padmanaban Sasthan Kuttipillai (Malden, Massachusetts);  Lindsay A. Wilhelmus (Lexington, Kentucky)
ABSTRACT An ultracapacitor that includes an energy storage cell immersed in an advanced electrolyte system and disposed within a hermetically sealed housing, the cell electrically coupled to a positive contact and a negative contact, wherein the ultracapacitor is configured to output electrical energy within a temperature range between about −40 degrees Celsius to about 210 degrees Celsius. Methods of fabrication and use are provided.
FILED Monday, September 18, 2023
APPL NO 18/369267
ART UNIT 2851 — Printing/Measuring and Testing
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/30 (20130101) Original (OR) Class
H01G 11/34 (20130101)
H01G 11/36 (20130101)
H01G 11/52 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/052 (20130101)
H01M 10/0563 (20130101)
H01M 10/0568 (20130101)
H01M 50/44 (20210101)
H01M 50/186 (20210101)
H01M 50/191 (20210101)
H01M 50/423 (20210101)
H01M 50/426 (20210101)
H01M 50/437 (20210101)
H01M 50/491 (20210101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/00 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/10 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 70/50 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166145 Sampayan et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Opcondys, Inc. (Manteca, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California);  Opcondys, Inc. (Manteca, California)
INVENTOR(S) Stephen E. Sampayan (Manteca, California);  Kristin C. Sampayan (Manteca, California)
ABSTRACT Devices, methods and techniques are disclosed to interrupt a fault current in a high-voltage direct-current circuit. In one example aspect, a device includes a mechanical switch including a pair of contacts configured to be positioned apart upon activation of the circuit breaker, and a photoconductive component connected in parallel with the mechanical switch. The photoconductive component is configured to establish a current upon activation of the circuit breaker. The photoconductive component comprises a crystalline material positioned to receive a pulsed light signal from a laser light source, and a pair of electrodes coupled to the crystalline material and configured to allow an electric field to be established across the crystalline material to generate the current.
FILED Monday, August 09, 2021
APPL NO 17/397699
ART UNIT 2839 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Electric Switches; Relays; Selectors; Emergency Protective Devices
H01H 89/00 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/161 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166173 Francisco et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Solid Power Operating, Inc. (Louisville, Colorado)
ASSIGNEE(S) Solid Power Operating, Inc. (Louisville, Colorado)
INVENTOR(S) Brian E. Francisco (Arvada, Colorado);  Heather A. S. Platt (Golden, Colorado);  Collin R. Becker (Boulder, Colorado);  Joshua Buettner-Garrett (Arvada, Colorado)
ABSTRACT A solid electrolyte material comprises Li, T, X and A wherein T is at least one of P, As, Si, Ge, Al, and B; X is one or more halogens or N; A is one or more of S and Se. The solid electrolyte material has peaks at 17.8°±0.75° and 19.2°±0.75° in X-ray diffraction measurement with Cu-Kα(1,2)=1.5418 Å and may include glass ceramic and/or mixed crystalline phases.
FILED Monday, May 02, 2022
APPL NO 17/734874
ART UNIT 1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/052 (20130101)
H01M 10/0562 (20130101) Original (OR) Class
H01M 2300/0068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166184 Johnson et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Christopher S. Johnson (Naperville, Illinois);  Anna Lee (Darien, Illinois)
ABSTRACT A process for charging a discharged electrochemical cell includes applying a voltage bias to the discharged electrochemical cell; and illuminating the cathode with a light source.
FILED Thursday, May 11, 2023
APPL NO 18/196350
ART UNIT 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/502 (20130101)
H01M 4/505 (20130101)
H01M 4/525 (20130101)
H01M 10/44 (20130101) Original (OR) Class
H01M 10/052 (20130101)
H01M 10/441 (20130101)
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 7/00 (20130101)
H02J 7/35 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166187 Gent et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Inlyte Energy, Inc. (San Leandro, California)
ASSIGNEE(S) Inlyte Energy, Inc. (San Leandro, California)
INVENTOR(S) William Gent (San Leandro, California);  Antonio Baclig (San Leandro, California);  Roger Bull (Derby, United Kingdom);  Stephen Brooker (Derby, United Kingdom);  Roger Tilley (Ashbourne, United Kingdom);  Roy Galloway (Derbyshire, United Kingdom)
ABSTRACT A method can include loading a battery with battery materials (e.g., electrolyte, cathode materials, anode materials), applying a first charge to the battery, applying a first discharge to the battery, cycling the battery (e.g., through subsequent charge and discharge cycles) where operating conditions in the subsequent charge and/or discharge cycles can be different from operating conditions in the first charge and/or first discharge.
FILED Monday, April 08, 2024
APPL NO 18/629518
ART UNIT 2859 — Printing/Measuring and Testing
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/054 (20130101)
H01M 10/058 (20130101)
H01M 10/443 (20130101)
H01M 10/446 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166328 Payne et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Stephen A. Payne (Castro Valley, California);  Nerine J. Cherepy (Piedmont, California);  Eric B. Duoss (Dublin, California);  Ivy Krystal Jones (Chicago, Illinois);  Zachary M. Seeley (Livermore, California);  Cheng Zhu (Livermore, California)
ABSTRACT In one aspect, a composition of matter includes: a plurality of particles in a thixotropic suspension to form an ink, where the plurality of particles are present in an amount of at least about 20 vol %, and the plurality of particles include: a first host medium material containing at least one of: one or more lasing species dopants; and one or more other dopant species; and a second host medium material containing at least one other dopant species. The composition of matter further includes a liquid phase present in an amount greater than 20 vol % and less than about 80 vol %, where the liquid phase comprises at least one of: at least one surfactant; at least one polar organic solvent; and at least one binder.
FILED Monday, September 21, 2020
APPL NO 17/027526
ART UNIT RD00 — Electrical Circuits and Systems
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/113 (20130101)
H01S 3/0617 (20130101) Original (OR) Class
H01S 3/0912 (20130101)
H01S 3/0941 (20130101)
H01S 3/1643 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166398 Forest et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Cary Brett Forest (Madison, Wisconsin);  Jeremiah Kirch (Waunakee, Wisconsin);  Douglass A Endrizzi (Monona, Wisconsin);  Jan Egedal (Cambridge, Massachusetts);  Jay Anderson (Madison, Wisconsin)
ABSTRACT A direct converter for an axisymmetric mirror confinement system provides a set of radially symmetric vanes charged to capture ions escaping along the axis of the confinement system and to convert their energy to electrical power. An electron trap positioned before the charged vanes uses a magnetic field to divert and collect electrons, separating them from the ions, and may support a radial electric field providing plasma control. The charged vanes may be constructed of or have a coating of a getter material absorbing neutrals derived from those ions after capture.
FILED Tuesday, March 15, 2022
APPL NO 17/654920
ART UNIT 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Producing a Reactive Propulsive Thrust, Not Otherwise Provided for
F03H 1/0068 (20130101)

Fusion Reactors
G21B 1/05 (20130101)

Dynamo-electric Machines
H02K 44/10 (20130101) Original (OR) Class

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 12162050 Hale et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Mike Hale (Hopewell Junction, New York);  Keith Hale (Hopewell Junction, New York);  Melinda Sims (Seattle, Washington)
ABSTRACT A system for extracting landfill gas from a landfill is provided. According to some embodiments, a control system for landfill gas extraction is provided. The control system uses a throttle to control flow of landfill gas extracted from the landfill. The throttle is actuated in use to vary the flow of gas between a well and a gas collection system, in accordance with a control algorithm that adjusts flow as a parameter in controlling gas extraction. The throttle is configured to ensure that there is at least some flow of landfill gas from the landfill to a gas output throughout operation. The extraction system provides an efficient system for landfill gas extraction, while mitigating a risk of creating undesired or unpleasant conditions and/or of violating regulations during operation.
FILED Monday, May 01, 2023
APPL NO 18/310343
ART UNIT 3672 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/12 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 50/30 (20130101)

Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management
Y02W 30/30 (20150501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162053 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (North Potomac, Maryland)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, April 10, 2023
APPL NO 18/132753
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 43/12 (20130101)
E21B 47/06 (20130101)
E21B 49/087 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163186 Mancebo
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Ricardo Mancebo (Hayward, California)
ASSIGNEE(S) Ricardo Mancebo (Hayward, California)
INVENTOR(S) Ricardo Mancebo (Hayward, California)
ABSTRACT The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (ACR).
FILED Monday, May 02, 2022
APPL NO 17/734226
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6853 (20130101) Original (OR) Class
C12Q 1/6862 (20130101)
C12Q 1/6862 (20130101)
C12Q 2523/109 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163773 Nguyen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
Naval Air Warfare Center Aircraft Division (NAWCAD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) iSenseCloud, Inc. (Milpitas, California)
ASSIGNEE(S) iSenseCloud, Inc. (San Jose, California)
INVENTOR(S) An-Dien Nguyen (Fremont, California);  An H. Nguyen (Fremont, California)
ABSTRACT A fiber optic voltage conditioner, and method therefor, generally relate to voltage conditioning. In such a fiber optic voltage conditioner, there is a laser, and an optical circulator is coupled to receive a light signal from the laser. A controller is coupled to the laser and is configured to generate first control information for wavelength-drift control of the laser. A data acquisition module is coupled to the controller and is configured to generate second control information for the controller for adjustment of the first control information. A photodetector is coupled to the optical circulator to receive a returned optical signal and is coupled to the data acquisition module to provide an analog output signal thereto. The photodetector is configured to generate the analog output signal responsive to the returned optical signal. The data acquisition module is configured to generate the second control information using the analog output signal.
FILED Friday, July 01, 2022
APPL NO 17/856914
ART UNIT 2828 — Semiconductors/Memory
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 11/165 (20130101) Original (OR) Class

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/3206 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 5/0612 (20130101)
H01S 5/0617 (20130101)
H01S 5/0622 (20130101)
H01S 5/0687 (20130101)
H01S 5/02415 (20130101)
H01S 5/4087 (20130101)
H01S 5/06804 (20130101)
H01S 5/06808 (20130101)
H01S 5/06837 (20130101)

Transmission
H04B 10/572 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166952 Redden
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology, Innovation and Partnerships (TIP)
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Blue River Technology Inc. (Sunnyvale, California)
ASSIGNEE(S) BLUE RIVER TECHNOLOGY INC. (Santa Clara, California)
INVENTOR(S) Lee Kamp Redden (Palo Alto, California)
ABSTRACT Described are methods for identifying the in-field positions of plant features on a plant by plant basis. These positions are determined based on images captured as a vehicle (e.g., tractor, sprayer, etc.) including one or more cameras travels through the field along a row of crops. The in-field positions of the plant features are useful for a variety of purposes including, for example, generating three-dimensional data models of plants growing in the field, assessing plant growth and phenotypic features, determining what kinds of treatments to apply including both where to apply the treatments and how much, determining whether to remove weeds or other undesirable plants, and so on.
FILED Monday, October 02, 2023
APPL NO 18/479504
ART UNIT 2671 — Computer Networks
CURRENT CPC
Electric Digital Data Processing
G06F 18/2415 (20230101)

Image Data Processing or Generation, in General
G06T 7/593 (20170101)
G06T 2207/10021 (20130101)
G06T 2207/20076 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/30252 (20130101)

Image or Video Recognition or Understanding
G06V 10/764 (20220101)
G06V 20/38 (20220101)
G06V 20/188 (20220101)
G06V 2201/12 (20220101)

Pictorial Communication, e.g Television
H04N 13/128 (20180501)
H04N 13/204 (20180501)
H04N 13/239 (20180501)
H04N 13/243 (20180501) Original (OR) Class
H04N 13/271 (20180501)
H04N 2013/0081 (20130101)
H04N 2013/0092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 12162218 Kim et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
Federally Funded Research and Development Center (FFRDC)
Operated by California Institute of Technology (CALTECH) at Pasadena, CA
National Science Foundation (NSF)
Office of The Director (OD)
Office of International Science and Engineering (OISE)
APPLICANT(S) THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (Las Vegas, Nevada)
ASSIGNEE(S) THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (Las Vegas, Nevada)
INVENTOR(S) Kwang J. Kim (Henderson, Nevada);  Alexandrea Washington (Las Vegas, Nevada);  Emma Chao (Henderson, Nevada);  Justin Neubauer (Las Vegas, Nevada);  Sophia Leon (Las Vegas, Nevada);  Zachary Frank (Las Vegas, Nevada);  Zakai Olsen (Las Vegas, Nevada)
ABSTRACT A modular and expandable 3D printer frame includes frame members to be coupled together to form a base defining an inner area. Each frame member includes at least one coupling member to removably couple the frame member to another of the frame members. The printer frame further includes first modular plates to be disposed within the inner area, and second modular plates to be disposed within the inner area and removably coupled to the first modular plates. The first and second modular plates, when coupled together, define a printer footprint.
FILED Wednesday, December 04, 2019
APPL NO 17/428424
ART UNIT 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/25 (20170801) Original (OR) Class
B29C 64/209 (20170801)
B29C 64/295 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 30/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162591 Nguyen et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S) Nhan Thanh Nguyen (Santa Clara, California);  Nicholas Bryan Cramer (San Jose, California);  Juntao Xiong (Irvine, California)
ABSTRACT An anti-phase rotor system for an aircraft may include at least one rotor with at least two rotor blades. The aerodynamic profile of these two blades may be selected to create counteracting blade vortices to break up harmonic reinforcement due to the rotor blade passage. The aerodynamic profile may create a non-planar motion of one or more rotor blade passages, whereby the individual rotor blades are not co-planar during the rotation of said rotor. The rotor system may include a duct, which may include stationary vanes or struts configured in a manner so as to break up harmonic excitation to the rotor. The interior area of the duct at the area of the blade rotation may be designed in a manner so as to create a destructive rotor blade tip vortex interference.
FILED Friday, December 18, 2020
APPL NO 17/127855
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Aeroplanes; Helicopters
B64C 27/001 (20130101) Original (OR) Class
B64C 27/463 (20130101)
B64C 27/467 (20130101)
B64C 2027/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163843 Aksoy et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) The Research Foundation for the State University of New York (Albany, New York)
ASSIGNEE(S) The Research Foundation for the State University of New York (Albany, New York)
INVENTOR(S) Mustafa Aksoy (Albany, New York);  John Bradburn (Menands, New York)
ABSTRACT Operations of radiometers may be improved by calculating calibration uncertainties for the radiometer. Initially, operational characteristics for the radiometer, and/or historical calibration parameters for a plurality of previously performed calibration processes using the radiometer may be obtained. Additionally, a calibration uncertainty for the radiometer based on the obtained operational characteristics for the radiometer and the obtained historical calibration parameters may be calculated, and desired, calibration parameters for the radiometer may be identified. The identified desired, calibration parameters may be based on the calculated, calibration uncertainty.
FILED Monday, November 15, 2021
APPL NO 17/526903
ART UNIT 2884 — Optics
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 5/10 (20130101) Original (OR) Class
G01J 5/80 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12164020 Bayer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Mustafa Mert Bayer (Irvine, California);  Ozdal Boyraz (Irvine, California)
ABSTRACT Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones.
FILED Friday, September 03, 2021
APPL NO 17/467012
ART UNIT 2877 — Optics
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/584 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 12161630 Rajashekara et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S) Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S) Gireesh Rajashekara (Wooster, Ohio);  Loic Deblais (Wooster, Ohio);  Yosra A. Helmy (Wooster, Ohio);  Dipak Kathayat (Wooster, Ohio);  Sally A. Miller (Wooster, Ohio)
ABSTRACT Disclosed herein are methods of treating a subject with a bacterial infection, or preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, or a derivative thereof, having the formula of SM1, SM3, SM4, or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, having the formula of SM1, SM3, SM4, or SM5. The methods are effective against an array of bacterial pathogens in various animals and plants.
FILED Friday, October 07, 2022
APPL NO 17/938872
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/50 (20130101)
A01N 43/52 (20130101)
A01N 47/44 (20130101)

Fodder
A23K 20/111 (20160501)
A23K 20/137 (20160501)
A23K 20/195 (20160501)
A23K 50/75 (20160501)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 31/155 (20130101)
A61K 31/407 (20130101)
A61K 31/496 (20130101)
A61K 31/546 (20130101)
A61K 31/4164 (20130101)
A61K 31/4184 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163176 Steele et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin)
INVENTOR(S) James L. Steele (Madison, Wisconsin);  Jeffrey Broadbent (Logan, Utah);  Ekkarat Phrommao (Madison, Wisconsin)
ABSTRACT An ethanologen for producing biofuel from one or more carbohydrates and reducing lactate and acetate production in a biofuel manufacturing process. The ethanologen is made by introducing into the ethanologen one or more exogenous genes required for production of a bacteriocin. The resulting ethanologen reduces lactate and acetate production by contaminant lactic acid bacteria by expression of the bacteriocin during the biofuel manufacturing process. Certain resulting ethanologens ferment sugars not naturally or not preferentially utilized by Saccharomyces cerevisiae during the manufacturing process.
FILED Thursday, December 16, 2021
APPL NO 17/553279
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Peptides
C07K 14/195 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/16 (20130101)
C12N 1/20 (20130101)
C12N 1/38 (20130101)
C12N 9/88 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/06 (20130101)
C12P 7/10 (20130101)
C12P 7/065 (20130101) Original (OR) Class
C12P 21/02 (20130101)

Enzymes
C12Y 101/01001 (20130101)
C12Y 401/01001 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 50/10 (20130101)
Y02E 50/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12163421 Cardiff
FUNDED BY
Environmental Protection Agency (EPA)
National Science Foundation (NSF)
Directorate of Geosciences (GEO)
Division of Earth Sciences (EAR)
Department of Agriculture (USDA)
U.S. Forest Service (FS)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Michael Cardiff (Madison, Wisconsin)
ABSTRACT A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation.
FILED Wednesday, March 15, 2023
APPL NO 18/121904
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/12 (20130101)
E21B 49/008 (20130101) Original (OR) Class
E21B 2200/20 (20200501)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 12161655 Cynamon et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Paratek Pharmaceuticals, Inc. (King Of Prussia, Pennsylvania);  United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S) Paratek Pharmaceuticals, Inc. (Boston, Massachusetts);  The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Michael Henry Cynamon (Dewitt, New York);  Michael P. Draper (Windham, New Hampshire);  Judith N. Steenbergen (Newtown, Pennsylvania);  S. Ken Tanaka (Bellevue, Washington)
ABSTRACT The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.
FILED Tuesday, September 03, 2019
APPL NO 17/273034
ART UNIT 1622 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/65 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12162818 Rettig et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S) Matthew Rettig (Los Angeles, California);  Michael E. Jung (Los Angeles, California);  D. Elshan Nakath G. Ralalage (Los Angeles, California);  Jiabin An (Los Angeles, California)
ABSTRACT The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
FILED Thursday, January 13, 2022
APPL NO 17/575027
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Acyclic or Carbocyclic Compounds
C07C 33/486 (20130101)
C07C 49/223 (20130101)
C07C 225/16 (20130101) Original (OR) Class
C07C 235/34 (20130101)
C07C 235/78 (20130101)
C07C 321/20 (20130101)

Heterocyclic Compounds
C07D 207/08 (20130101)
C07D 211/32 (20130101)
C07D 241/04 (20130101)
C07D 265/30 (20130101)
C07D 303/32 (20130101)
C07D 303/40 (20130101)
C07D 307/52 (20130101)
C07D 333/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Security Agency (NSA) 

US 12166259 Osborn et al.
FUNDED BY
National Security Agency (NSA)
APPLICANT(S) The Government of the United States as represented by the Director, National Security Agency (Ft. George G. Meade, Maryland)
ASSIGNEE(S) Government of the United States as represented by the Director, National Security Agency (Ft. George G. Meade, Maryland)
INVENTOR(S) Kevin D. Osborn (Clarksville, Maryland);  Waltraut Wustmann (Dunedin, New Zealand)
ABSTRACT A reversible superconducting circuit includes two Josephson transmission lines. Inductors connect Josephson Junctions in the array. Each transmission line passes a fluxon along the Junctions. The circuit includes an interface with first and second shunt capacitors coupled to the first and second transmission lines, and a third shunt capacitor, forming a connecting circuit with the first and second shunt capacitors. The shunt capacitors include Josephson junctions in parallel. The connecting circuit receives an input fluxon and transmits an output fluxon. The circuit also includes a Josephson Junction and inductor in parallel with the third shunt capacitor, forming a storage circuit. The storage circuit stores a SFQ. The output fluxon has polarity based on the SFQ stored when the first fluxon is received. The input fluxon causes the polarity of the stored SFQ to be the same as the polarity of the input fluxon, immediately after the input fluxon is received.
FILED Tuesday, September 12, 2023
APPL NO 18/367203
ART UNIT 2842 — Electrical Circuits and Systems
CURRENT CPC
Static Stores
G11C 19/32 (20130101)

Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type
H01P 3/026 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 12166909 Sohanghpurwala et al.
FUNDED BY
National Security Agency (NSA)
APPLICANT(S) Graf Research Corporation (Blacksburg, Virginia)
ASSIGNEE(S) Graf Research Corporation (Blacksburg, Virginia)
INVENTOR(S) Ali Asgar Sohanghpurwala (Decatur, Georgia);  Scott Harper (Blacksburg, Virginia);  Jonathan Graf (Blacksburg, Virginia);  Carlton Fraley (Christiansburg, Virginia);  Alan Cook (Christiansburg, Virginia);  Timothy Dunham (Roanoke, Virginia)
ABSTRACT A computer system traces an original electronic design automation (EDA) implementation process for electronic hardware designs. The original EDA implementation process includes multiple subprocesses to convert a hardware model to a physically-realized electronic circuit. The system inputs a cryptographic key and design information that includes the hardware model, constraints, properties, implementation settings, and other directives for directing the conversion. The cryptographic key and design information are processed to generate a sequence of instructions to execute and provide traceability of each subprocess. For each subprocess, the system gathers intermediate design state and implementation settings resulting from or influencing execution of the subprocess; combines the intermediate design state and implementation settings into a data string and determines a cryptographic hash value for the data string; digitally signs the cryptographic hash value using a digital signature certificate derived from the cryptographic key to generate a signed hash; stores the signed hash and identifiers associated with data files used for determining the cryptographic hash value to an electronic ledger to generate an updated electronic ledger; authenticates the signed hash from the electronic ledger to generate an authenticated signed hash; reconstructs a hash from the data files stored in the electronic ledger to generate a reconstructed hash; compares the authenticated signed hash with the reconstructed hash, and in response to a mismatch, generates an error signal. The steps are repeated for each subsequent subprocess, and the traced EDA implementation process results are stored in memory.
FILED Thursday, September 22, 2022
APPL NO 17/950341
ART UNIT 2451 — Computer Networks
CURRENT CPC
Electric Digital Data Processing
G06F 30/31 (20200101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/50 (20220501) Original (OR) Class
H04L 9/3247 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 12166662 Yuksel et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
INVENTOR(S) Murat Yuksel (Orlando, Florida);  Ammar Farooq (Orlando, Florida)
ABSTRACT A system and method for disconnection tolerant network routing, termed Binary State Distance Vector Routing (BSDVR). BSDVR provides for unicast routing on partitioned networks by introducing binary state information for distance vector (DV) entries to compute unicast paths. In the presence of network partitions, BSDVR effectively avoids the count-to-infinity problem and operates with control overhead less than traditional DV routing by an order of magnitude, leading to much better convergence times for failures.
FILED Friday, May 05, 2023
APPL NO 18/312975
ART UNIT 2444 — Computer Networks
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/22 (20130101)
H04L 45/28 (20130101)
H04L 45/123 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 12165386 Fry
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Mark Fry (Marco Island, Florida)
ABSTRACT Systems and methods of detecting a vortex made by a travelling object is disclosed. Techniques include positioning a media collector to capture a visual media file of the vortex. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file.
FILED Thursday, January 25, 2024
APPL NO 18/422997
ART UNIT 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Image or Video Recognition or Understanding
G06V 10/25 (20220101)
G06V 10/74 (20220101)
G06V 10/761 (20220101)
G06V 10/764 (20220101) Original (OR) Class
G06V 10/7715 (20220101)
G06V 20/52 (20220101)

Signalling or Calling Systems; Order Telegraphs; Alarm Systems
G08B 21/182 (20130101)

Traffic Control Systems
G08G 5/003 (20130101)
G08G 5/0017 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Environmental Protection Agency (EPA) 

US 12163421 Cardiff
FUNDED BY
Environmental Protection Agency (EPA)
National Science Foundation (NSF)
Directorate of Geosciences (GEO)
Division of Earth Sciences (EAR)
Department of Agriculture (USDA)
U.S. Forest Service (FS)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Michael Cardiff (Madison, Wisconsin)
ABSTRACT A system for monitoring and establishing physical properties of a subsurface formation at a testing site having a source well and one or more receiver wells may include a pump, a data collection system, and a controller. The controller may cause the pump to extract fluid from and inject fluid into the source well based on one or more measures indicative of an amount of liquid in the source well. The controller may receive measures related to pressures in the receiver wells and physical properties of the subsurface formation may be determined based on the measures related to pressures in the receiver well. In some cases, noise may be removed from the measures related to pressures in the receiver wells to facilitate determining the physical properties of the subsurface formation.
FILED Wednesday, March 15, 2023
APPL NO 18/121904
ART UNIT 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/12 (20130101)
E21B 49/008 (20130101) Original (OR) Class
E21B 2200/20 (20200501)
VIEW PATENT @ USPTO:  Full Text   PDF 

U.S. State Government 

US 12167184 Fahs et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
U.S. State Government
State of New York
Empire State Development (ESD)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) Rensselaer Polytechnic Institute (Troy, New York)
INVENTOR(S) Bassem Fahs (Troy, New York);  Robert F. Karlicek, Jr. (Mechanicville, New York);  Mona Mostafa Hella (Watervliet, New York)
ABSTRACT A cross-connect switch architecture is described. A cross-connect switch device includes a cross-point switch array, a plurality of photo detectors and a plurality of amplifiers. The cross-point switch array includes a plurality of switches. Each switch is coupled between a respective photo detector and a respective amplifier and is configured to couple the respective photo detector to the respective amplifier when the switch is selected.
FILED Tuesday, April 02, 2019
APPL NO 17/043795
ART UNIT 2874 — Optics
CURRENT CPC
Amplifiers
H03F 3/085 (20130101)

Selecting
H04Q 11/0005 (20130101) Original (OR) Class
H04Q 11/0062 (20130101)
H04Q 2011/0016 (20130101)
H04Q 2011/0024 (20130101)
H04Q 2011/0026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 12162702 Stratton et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S) United States Postal Service (Washington, District of Columbia)
INVENTOR(S) Christopher M. Stratton (Springfield, Virginia);  Gregory J. Smith (Arlington, Virginia);  Thomas C. Potter (Oak Hill, Virginia);  Wayne R. Perry-Eaton (Leesburg, Virginia)
ABSTRACT Features for loading, transporting and unloading of items are disclosed. Systems, devices and methods for such operations using a tray are described. In some embodiments, a tray having a moveable bottom allows for switching between a configuration for loading and unloading items in and out of the tray and a configuration for transportation of items inside the tray. The trays may also be stacked, for transportation of multiple trays at once, and nested, for saving space when storing the trays. In some embodiments, the trays may be used in conjunction with loading and unloading systems.
FILED Friday, February 11, 2022
APPL NO 17/650831
ART UNIT 3652 — Material and Article Handling
CURRENT CPC
Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors
B65G 65/32 (20130101) Original (OR) Class
B65G 65/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 12165526 Roup et al.
FUNDED BY
APPLICANT(S) Rockwell Collins, Inc. (Cedar Rapids, Iowa)
ASSIGNEE(S) Rockwell Collins, Inc. (Cedar Rapids, Iowa)
INVENTOR(S) Alexander V. Roup (Centreville, Virginia);  Bryan M. Krawiec (Ashburn, Virginia);  Angus L. McLean (Bradenton, Florida);  Vladislav Gavrilets (Mclean, Virginia)
ABSTRACT A system for providing maneuvering behaviors to a vehicle is disclosed. The system may include one or more controllers communicatively coupled to one or more vehicles. The one or more controllers may include one or more processors configured to execute one or more program instructions causing the one or more processors to: initiate one or more maneuver primitives in response to decision engine selection; receive a plurality of input parameters for the one or more maneuver primitives, the plurality of input parameters including one or more initialization definition input parameters, one or more goal definition input parameters, one or more navigation state input parameters, one or more design input parameters, and one or more vehicle performance envelope input parameters; and generate one or more control signals at one or more predetermined intervals of time to maneuver the one or more vehicles based on the decision engine selection.
FILED Tuesday, December 22, 2020
APPL NO 17/131401
ART UNIT 3666 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Systems for Controlling or Regulating Non-electric Variables
G05D 1/0022 (20130101)
G05D 1/104 (20130101)
G05D 1/106 (20190501)

Traffic Control Systems
G08G 5/003 (20130101) Original (OR) Class
G08G 5/0008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

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     National Institutes of Health (NIH)
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APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20241210.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

HAVE MORE QUESTIONS?

info@wayfinder.digital