FedInvent™ Patents
Patent Details for Tuesday, December 17, 2024
This page was updated on Thursday, December 19, 2024 at 08:30 PM GMT
Department of Health and Human Services (HHS)
| US 12167729 | Uygun et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Mustafa Korkut Uygun (Newton, Massachusetts); Shannon Noella Tessier (Framingham, Massachusetts); Renier Johan de Vries (Boston, Massachusetts) |
| ABSTRACT | This disclosure is related to methods of preserving biological samples such as organs, and tissue. The present disclosure relates to methods of subzero preservation of biological tissue samples, such as entire organs from mammals, e.g., humans. The present disclosure is based, at least in part, on the discovery that biological tissue samples can be supercooled while minimizing formation of ice crystals by reducing liquid-air interfaces and lowering the melting point of the tissue samples, e.g., organs, or liquid in the tissue samples by use of cryoprotective agents while ensuring uniform distribution of cryoprotective agents throughout the biological sample by using improved perfusion techniques. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/058279 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) A01N 1/0247 (20130101) A01N 1/0284 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12167864 | Maxwell et al. |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Adam D. Maxwell (Woodinville, Washington); Bryan W. Cunitz (Seattle, Washington); Wayne Kreider (Seattle, Washington); Oleg A. Sapozhnikov (Seattle, Washington); Ryan S. Hsi (Seattle, Washington); Michael R. Bailey (Seattle, Washington) |
| ABSTRACT | A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm). |
| FILED | Friday, January 06, 2023 |
| APPL NO | 18/151013 |
| ART UNIT | 3797 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/22012 (20130101) Original (OR) Class A61B 2017/22014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168003 | Patel et al. |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | NEW YORK UNIVERSITY (New York, New York) |
| INVENTOR(S) | Preeyam S. Patel (New York, New York); Robert J. Schneider (New York, New York) |
| ABSTRACT | Disclosed herein is a method of inhibiting T Follicular Helper (TFH) cell-mediated differentiation and/or activation in a subject. This method involves administering to a subject in need of treatment for an autoimmune disorder a eukaryotic translation initiation factor 4E (eIF4E) inhibitor to inhibit TFH cell-mediated differentiation and/or activation in the subject. Also disclosed is a method of inhibiting T Follicular Helper (THF) cell differentiation or TFH cell activity. |
| FILED | Monday, February 06, 2023 |
| APPL NO | 18/165113 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168005 | Winter |
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| FUNDED BY |
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| APPLICANT(S) | University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| ASSIGNEE(S) | UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER (Cleveland, Ohio) |
| INVENTOR(S) | Jordan M. Winter (Shaker Heights, Ohio) |
| ABSTRACT | The invention provides methods of treating cancer characterized by the presence of one or both of wild type isocitrate dehydrogenase 1 (IDH1) gene and wild type IDH1 enzyme, by administering compounds that inhibit mutant IDH1 enzyme, such as Ivosidenib (AG-120, IVOSIDENIB®). The invention also provides cell-based methods for determining anti-cancer activity of test compounds under in vitro conditions of low concentrations of magnesium ion and/or glucose. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/030844 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168006 | Hergenrother et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. Hergenrother (Champaign, Illinois); Jessie Peh (Champaign, Illinois); Matthew Boudreau (Newton, Massachusetts) |
| ABSTRACT | The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant problem in the clinic, limiting the long-term effectiveness of most of these drugs. Herein is demonstrated a strategy to overcome this resistance through drug-induced MEK cleavage (via direct procaspase-3 activation) combined with targeted kinase inhibition. This combination effect is shown to be general across diverse tumor histologies (melanoma, lung cancer, and leukemia) and driver mutations (mutant BRAF or EGFR, fusion kinases EML4-ALK and BCR-ABL). Caspase-3-mediated degradation of MEK kinases results in sustained pathway inhibition and substantially delayed or eliminated resistance in cancer cells in a manner superior to combinations with MEK inhibitors. These data suggest the generality of drug-mediated MEK kinase cleavage as a therapeutic strategy to prevent resistance to targeted anticancer therapies. |
| FILED | Monday, November 28, 2022 |
| APPL NO | 18/059024 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/495 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4523 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168008 | Kovach et al. |
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| FUNDED BY |
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| APPLICANT(S) | LIXTE BIOTECHNOLOGY, INC. (Pasadena, California); THE UNITED STATES OF AMERICA, as Represented by the Secretary (Bethesda, Maryland) |
| ASSIGNEE(S) | Lixte Biotechnology, Inc. (Pasadena, California); The United States of America, as Represented by the Secretary Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John S. Kovach (Pasadena, California); Zhengping Zhuang (Bethesda, Maryland); Sze Chun Winson Ho (Bethesda, Maryland); Herui Wang (Bethesda, Maryland); Rongze Lu (Sunnyvale, California) |
| ABSTRACT | The present invention provides a method of treating a subject afflicted with cancer comprising administering to the subject an effective amount of a PP2A inhibitor. |
| FILED | Friday, December 08, 2017 |
| APPL NO | 16/467721 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168013 | Gendelman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Howard Gendelman (Omaha, Nebraska); Benson Edagwa (Omaha, Nebraska) |
| ABSTRACT | The present invention provides prodrugs and methods of use thereof. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655483 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1641 (20130101) A61K 31/519 (20130101) A61K 31/5365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168028 | Hare et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| INVENTOR(S) | Joshua M. Hare (Miami Beach, Florida); Konstantinos Chatzistergos (Miami, Florida) |
| ABSTRACT | The disclosure provides a method of obtaining a population of cardiomyogenic precursor cells. The method comprises (a) differentiating induced pluripotent stem cells (iPSCs) to iPSC-derived cardiac precursor cells; and (b) isolating cardiac precursor cells expressing mammalian growth hormone-releasing hormone receptor (GHRHR) to obtain a population of iPSC-derived cardiomyogenic precursor cells. |
| FILED | Friday, September 21, 2018 |
| APPL NO | 16/649522 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 38/25 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/38 (20130101) C12N 5/10 (20130101) C12N 5/0657 (20130101) C12N 5/0696 (20130101) C12N 2501/60 (20130101) C12N 2501/85 (20130101) C12N 2501/415 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168035 | Tizabi |
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| APPLICANT(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | Howard University (Washington, District of Columbia) |
| INVENTOR(S) | Yousef Tizabi (Silver Spring, Maryland) |
| ABSTRACT | C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729502 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/164 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168037 | Dagvadorj et al. |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Jargalsaikhan Dagvadorj (Los Angeles, California); Moshe Arditi (Encino, California); Gantsetseg Tumurkhuu (Los Angeles, California); Janet Markman (Encino, California) |
| ABSTRACT | Described herein are methods and compositions for the treatment of cancer and cancer metastasis. Methods for the reduction or prevention of cancer metastasis are also described. In particular, the present invention discloses the use of the IL-1α pro-piece peptide in the treatment cancer and cancer metastasis. |
| FILED | Wednesday, January 23, 2019 |
| APPL NO | 16/963421 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/2006 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168042 | Raines et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ronald Raines (Cambridge, Massachusetts); Ian Windsor (Brighton, Massachusetts) |
| ABSTRACT | Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are characterized by a specific protease (e.g., HTV-1 protease). |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913924 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/55 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168056 | Makale et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Milan T. Makale (San Diego, California); Wolfgang J. Wrasidlo (La Jolla, California); Santosh Kesari (La Jolla, California); Joanna McKittrick (La Jolla, California); Gustavo A. Hirata Flores (Ensenada, Mexico); Olivia Graeve (La Mesa, California) |
| ABSTRACT | There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564812 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 41/0042 (20130101) Original (OR) Class A61K 47/6923 (20170801) A61K 47/6929 (20170801) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/06 (20130101) A61N 5/10 (20130101) A61N 2005/0661 (20130101) A61N 2005/1098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168123 | Frank et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Loren M. Frank (San Anselmo, California); Jason Chung (Oakland, California) |
| ABSTRACT | The present disclosure generally provides methods of implanting an implantable device in contact with a brain of a subject. Also provided are kits and systems for the implantation of one or more implantable devices. |
| FILED | Tuesday, May 02, 2023 |
| APPL NO | 18/142279 |
| ART UNIT | 3796 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6868 (20130101) A61B 17/3468 (20130101) A61B 2090/103 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) Original (OR) Class A61N 1/0539 (20130101) A61N 1/37223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168129 | Noble et al. |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Jack H. Noble (Nashville, Tennessee); Robert F. Labadie (Nashville, Tennessee); Benoit M. Dawant (Nashville, Tennessee) |
| ABSTRACT | A patient-customized electrode array (EA) includes a plurality of electrodes, {Ei}, assembled in a pre-curved form, wherein the curvature of the EA at the i-th electrode Ei is characterized with a curvature that matches the curvature of the i-th point Pi of a structure curve in the cochlea of a patient where the i-th electrode Ei is to be placed, wherein i=1, 2, 3, . . . N, N is an integer greater than zero. |
| FILED | Thursday, December 21, 2023 |
| APPL NO | 18/391840 |
| ART UNIT | 2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/1076 (20130101) A61B 6/032 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) A61B 2034/108 (20160201) A61B 2505/05 (20130101) A61B 2562/043 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0541 (20130101) A61N 1/36039 (20170801) Original (OR) Class Image Data Processing or Generation, in General G06T 7/12 (20170101) G06T 7/181 (20170101) G06T 11/005 (20130101) G06T 2207/30008 (20130101) G06T 2211/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168225 | Mendoza et al. |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Estevan Mendoza (Mountain View, California); Eric Warner (Oceanside, California) |
| ABSTRACT | Embodiments in accordance with the present disclosure are directed to sample collecting and dispensing methods and apparatuses. An example apparatus includes a capillary sampler disposed on a device first end, wherein the capillary sampler is configured to collect a fluid sample via an opening and a capillary body. The apparatus further includes a reagents chamber in fluid communication with the capillary sampler, and a barrier assembly disposed between the capillary sampler and the reagents chamber, wherein the barrier assembly is configured to separate fluid in the reagents chamber from the capillary sampler. A plunger assembly disposed on a device second end opposite the device first end, may modify the barrier assembly to dispense the fluid from the reagents chamber to the capillary sampler responsive to application of a force in the direction of the device first end. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/295195 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/022 (20130101) Original (OR) Class B01L 3/502 (20130101) B01L 2200/16 (20130101) B01L 2200/026 (20130101) B01L 2200/0684 (20130101) B01L 2300/14 (20130101) B01L 2300/044 (20130101) B01L 2300/048 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/0838 (20130101) B01L 2400/0406 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/14 (20130101) G01N 2001/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168639 | Shulman et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Gerald I. Shulman (East Haven, Connecticut); David A. Spiegel (New Haven, Connecticut) |
| ABSTRACT | The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent. |
| FILED | Wednesday, January 11, 2023 |
| APPL NO | 18/153160 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/085 (20130101) Acyclic or Carbocyclic Compounds C07C 205/37 (20130101) Original (OR) Class Steroids C07J 41/0055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168648 | Medina et al. |
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| APPLICANT(S) | Epiodyne, Inc. (San Francisco, California) |
| ASSIGNEE(S) | EPIODYNE, INC. (San Francisco, California) |
| INVENTOR(S) | Julio Cesar Medina (South San Francisco, California); Alok Nerurkar (San Diego, California); Corinne Sadlowski (London, United Kingdom); Frederick Seidl (San Mateo, California); Heng Cheng (Fremont, California); Jason Duquette (Millbrae, California); John Lee (Pacifica, California); Martin Holan (Stamford, Connecticut); Pingyu Ding (Foster City, California); Xiaodong Wang (South San Francisco, California); Tien Widjaja (Lafayette, Colorado); Thomas Nguyen (Newbury Park, California); Ulhas Bhatt (Fremont, California); Yihong Li (South San Francisco, California); Zhi-liang Wei (Foster City, California) |
| ABSTRACT | Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds. |
| FILED | Monday, February 13, 2023 |
| APPL NO | 18/168155 |
| ART UNIT | 1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/65 (20130101) Heterocyclic Compounds C07D 213/56 (20130101) C07D 239/26 (20130101) C07D 263/58 (20130101) C07D 277/30 (20130101) Original (OR) Class C07D 295/155 (20130101) C07D 307/54 (20130101) C07D 333/24 (20130101) C07D 401/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168663 | Gray et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Yanke Liang (Belmont, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/034822 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/454 (20130101) A61K 31/4162 (20130101) A61K 31/4162 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168664 | Petrukhin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Konstantin Petrukhin (New Windsor, New York); Kirsten Alison Rinderspacher (Mount Vernon, New York); Shi-Xian Deng (White Plains, New York); Andras Varadi (New York, New York); Boglarka Racz (New York, New York); Peter Bernstein (Philadelphia, Pennsylvania); Patricia C. Weber (Yardley, Pennsylvania); Donald W. Landry (New York, New York); Andrew S. Wasmuth (Brooklyn, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Konstantin Petrukhin (New Windsor, New York); Kirsten Alison Rinderspacher (Mount Vernon, New York); Shi-Xian Deng (White Plains, New York); Andras Varadi (New York, New York); Boglarka Racz (New York, New York); Peter Bernstein (Philadelphia, Pennsylvania); Patricia C. Weber (Yardley, Pennsylvania); Donald W. Landry (New York, New York); Andrew S. Wasmuth (Brooklyn, New York) |
| ABSTRACT | The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, C1-C4 alkyl, aryl or heteroaryl; X is N or CR6, wherein R6 is H, OH, or halogen; A is absent or present, and when present is B has the structure: or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085791 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168671 | Muir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| INVENTOR(S) | Tom W. Muir (Princeton, New Jersey); Rob C. Oslund (Princeton, New Jersey); Jung-Min Kee (Ulsan, South Korea) |
| ABSTRACT | Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. |
| FILED | Tuesday, March 29, 2022 |
| APPL NO | 17/707330 |
| ART UNIT | 1678 — Organic Chemistry |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65031 (20130101) Original (OR) Class Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168675 | Nabel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Chestnut Hill, Massachusetts); Srinivas Rao (Columbia, Maryland); Wataru Akahata (Kensington, Maryland) |
| ABSTRACT | The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs. |
| FILED | Wednesday, June 07, 2023 |
| APPL NO | 18/331083 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/53 (20130101) A61K 2039/575 (20130101) A61K 2039/5258 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/36122 (20130101) C12N 2770/36123 (20130101) C12N 2770/36134 (20130101) C12N 2770/36151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168680 | Wong et al. |
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| FUNDED BY |
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| APPLICANT(S) | Altor BioScience LLC (Culver City, California) |
| ASSIGNEE(S) | Altor Bioscience, LLC (Culver City, California) |
| INVENTOR(S) | Hing C. Wong (Culver City, California); Peter Rhode (Culver City, California); Xiaoyun Zhu (Culver City, California); Kai-Ping Han (Culver City, California) |
| ABSTRACT | The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention. |
| FILED | Monday, April 24, 2023 |
| APPL NO | 18/305965 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/1774 (20130101) A61K 38/1793 (20130101) A61K 38/2086 (20130101) Peptides C07K 14/5443 (20130101) Original (OR) Class C07K 14/7051 (20130101) C07K 14/7155 (20130101) C07K 16/18 (20130101) C07K 16/28 (20130101) C07K 2319/00 (20130101) C07K 2319/31 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) C07K 2319/75 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/09 (20130101) C12N 15/62 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168685 | Pasqualini et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R. M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047533 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 47/6891 (20170801) A61K 47/68031 (20230801) A61K 47/68033 (20230801) A61K 49/0008 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/1037 (20130101) C12N 2810/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168691 | Fan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Zhen Fan (Houston, Texas); Yang Lu (Houston, Texas); Songho Qiu (Houston, Texas) |
| ABSTRACT | The present disclosure provides a bispecific antibody comprising an IgG linked to an scFv, wherein the VII domain of the IgG is linked to the VH domain of the scFv, the bispecific antibody binding a human vascular endothelial growth factor (VEGF) family protein and an epidermal growth factor receptor (EGFR) family protein. Further embodiments provide pharmaceutical compositions comprising the bispecific antibody of the embodiments and aspects thereof and a pharmaceutically acceptable carrier. Further embodiments provide various methods of treating cancer in a subject comprising administering a bispecific antibody of the embodiments and aspects thereof to the subject. A further embodiment provides a kit comprising the bispecific antibody. |
| FILED | Friday, May 31, 2019 |
| APPL NO | 17/058414 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/22 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168696 | Spriggs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Eureka Therapeutics, Inc. (Emeryville, California) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Eureka Therapeutics, Inc. (Emeryville, California) |
| INVENTOR(S) | David Spriggs (New York, New York); Javier Morales (Emeryville, California); Yoko Nakano (Emeryville, California); Hong Liu (Emeryville, California) |
| ABSTRACT | Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/292749 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/3092 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168700 | McCully et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | James D. McCully (Marblehead, Massachusetts); Sidney Levitsky (Boston, Massachusetts); Douglas B. Cowan (West Roxbury, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Sitaram M. Emani (Boston, Massachusetts) |
| ABSTRACT | The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions. |
| FILED | Friday, September 01, 2023 |
| APPL NO | 18/459892 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/42 (20130101) A61B 6/503 (20130101) A61B 8/0883 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 35/34 (20130101) A61K 47/6901 (20170801) A61K 49/0002 (20130101) A61K 49/1821 (20130101) A61K 49/1896 (20130101) A61K 51/0421 (20130101) A61K 51/1203 (20130101) A61K 51/1282 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/468 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168780 | Sentman |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Charles L. Sentman (Grantham, New Hampshire) |
| ABSTRACT | The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same. |
| FILED | Tuesday, May 12, 2020 |
| APPL NO | 16/872438 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) A61K 2035/124 (20130101) A61K 2039/585 (20130101) A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/515 (20130101) C12N 2510/02 (20130101) C12N 2511/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168789 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); University of Tokyo (Tokyo, Japan) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); UNIVERSITY OF TOKYO (Tokyo, Japan) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Winston Yan (Cambridge, Massachusetts); Osamu Nureki (Tokyo, Japan); Kaijie Zheng (Cambridge, Massachusetts); Le Cong (Cambridge, Massachusetts); Hiroshi Nishimasu (Tokyo, Japan); Fei Ran (Cambridge, Massachusetts); Yinqing Li (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/101867 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 2299/00 (20130101) C07K 2319/09 (20130101) C07K 2319/20 (20130101) C07K 2319/70 (20130101) C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) G16B 15/20 (20190201) G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168802 | Lenardo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Michael J. Lenardo (Bethesda, Maryland); Helen Su (Bethesda, Maryland); Ahmet Oguzhan Ozen (Istanbul, Turkey); William Andrew Comrie (Rockville, Maryland); Kaan Boztug (Vienna, Austria); Rico Chandra Ardy (Vienna, Austria) |
| ABSTRACT | Disclosed herein are methods of diagnosing, and treating and/or preventing CD55-deficiency, hyperactivation of complement, angiopathic thrombosis and protein-losing enteropathy (CHAPLE). The method of diagnosing includes: providing a sample from a patient; performing an assay detecting at least one of at least one mutation in a DNA sequence of a CD55 gene, at least one mutation in a RNA sequence of a CD55 transcript, at least one mutation in a DNA sequence of a CD55 complementary-DNA (cDNA), CD55 protein, CD55 protein binding, complement deposition or combination thereof, and diagnosing the patient with CHAPLE. The method of treating and/or preventing at least one symptom of CHAPLE includes: administering an effective amount of a composition comprising at least one complement inhibitor to a subject in need thereof, wherein the composition is effective in treating or preventing at least on symptom of CHAPLE. The disclosure further relates to compositions effective at treating and/or preventing CHAPLE. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/154745 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Peptides C07K 16/40 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169196 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Gabsang Lee (Baltimore, Maryland); Kathryn Wagner (Baltimore, Maryland); Congshan Sun (Baltimore, Maryland) |
| ABSTRACT | Methods for identifying compounds in the treatment of muscular dystrophies, include the use of disease relevant cells derived from a patient. Compounds identified by these methods are useful in the treatment of muscular dystrophy. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 16/840302 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) C12N 5/0696 (20130101) C12N 2501/60 (20130101) C12N 2501/602 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2503/02 (20130101) C12N 2506/45 (20130101) C12N 2506/1307 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 12167919 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Quan Zhang (Winchester, Massachusetts); Gary Strangman (Boxford, Massachusetts) |
| ABSTRACT | A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. A perturbation unit provide an optical perturbation to the one or more superficial biological layers. An optical signal generator transmits optical signals at one or more near-infrared wavelengths. An optical signal receiver acquires a set of optical signal data preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation. A signal processor determines, using the set of optical signal data, a set of optical characteristics and separates, using the set of optical characteristics, a target optical signal. The signal processor generates a report indicative of a movement of the targeted biological tissue within the subject. The movement of the targeted biological layer is calculated using the target optical signal. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538583 |
| ART UNIT | 3798 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6814 (20130101) A61B 5/14553 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168216 | Weston et al. |
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| FUNDED BY |
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| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NuMat Technologies, Inc. (Chicago, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); Edwin Alfonso Argueta Fajardo (Chicago, Illinois); William Morris (Chicago, Illinois); John Paul Siegfried (Chicago, Illinois); Patrick Emmett Fuller (Chicago, Illinois) |
| ABSTRACT | This invention relates to metal organic framework (MOF) compositions, methods of preparing them and methods of using them. The MOF compositions are characterized in that at least a portion of the linker molecule is an amino containing organic linker. The MOF also has a crystal size of greater than 1 μm and has been treated with an acid wash to provide a MOF in which at least 55% of the amino groups are activated amino groups of the form —NH2. The MOF compositions are useful in adsorbing various contaminants from various gas stream. One specific example is adsorbing NO2 from an air stream. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540245 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/04 (20130101) B01D 2253/204 (20130101) B01D 2253/304 (20130101) B01D 2253/306 (20130101) B01D 2253/311 (20130101) B01D 2257/404 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3071 (20130101) B01J 20/3085 (20130101) B01J 20/28011 (20130101) B01J 20/28064 (20130101) B01J 20/28071 (20130101) B01J 20/28073 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168529 | Murphey et al. |
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| FUNDED BY |
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| APPLICANT(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| INVENTOR(S) | Thomas W Murphey (Fort Collins, Colorado); Levi Nicholson (Wellington, Colorado) |
| ABSTRACT | A self-deployable array of panels includes a plurality of panels, each panel having a first compressed panel thickness state and a second expanded panel thickness state, and including a spring bias element biased to the second expanded panel thickness state. A plurality of locking hinges hingedly couple each of the panels to an adjoining panel. Each locking hinge is biased to an open position. A release of stored potential energy of both of the spring bias element biased to the second expanded panel thickness state, and the locking hinges biased to the open position causes the self-deployable array of panels to self-deploy from a folded stowed state. A single part offset locking hinge is also described. |
| FILED | Tuesday, December 20, 2022 |
| APPL NO | 18/068716 |
| ART UNIT | 3677 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/44 (20130101) B64G 1/443 (20130101) Original (OR) Class B64G 1/2222 (20230801) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/12 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 30/10 (20141201) H02S 30/20 (20141201) Technical Subjects Covered by Former US Classification Y10T 403/45 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168612 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); National Central University (Taoyuan, Taiwan) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); National Central University (Taoyuan, Taiwan) |
| INVENTOR(S) | T. Randall Lee (Houston, Texas); Riddhiman Medhi (Houston, Texas); Sang Ho Lee (Houston, Texas); Chien-Hung Li (Kaohsiung, Taiwan); Allan J. Jacobson (Houston, Texas); Tai-Chou Lee (Taoyuan, Taiwan) |
| ABSTRACT | The present disclosure relates to a strategy to synthesize antimony- and zinc-doped tin oxide particles with tunable band gap characteristics. The methods yield stable and monodispersed particles with great control on uniformity of shape and size. The methods produce undoped and antimony and zinc-doped tin oxide stand-alone and core-shell particles, both nanoparticles and microparticles, as well as antimony and zinc-doped tin oxide shells for coating particles, including plasmonic core particles. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/425783 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/14 (20130101) B01J 23/18 (20130101) B01J 23/52 (20130101) B01J 35/19 (20240101) B01J 35/39 (20240101) B01J 37/04 (20130101) B01J 37/08 (20130101) B01J 37/0213 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 19/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/84 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/51 (20130101) C01P 2004/64 (20130101) C01P 2006/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168699 | Cavacini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Westborough, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Westborough, Massachusetts) |
| INVENTOR(S) | Lisa Cavacini (Boston, Massachusetts); Mark S. J. Klempner (Boston, Massachusetts) |
| ABSTRACT | The invention provides anti-polymeric IgA (plgA) antibodies and methods of using the same. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/598385 |
| ART UNIT | 1678 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 16/4241 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168727 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| INVENTOR(S) | Liangbing Hu (Potomac, Maryland); Mingwei Zhu (Nanjing, China PRC); Tian Li (West Lafayette, Indiana); Amy S. Gong (Potomac, Maryland); Jianwei Song (College Park, Maryland) |
| ABSTRACT | Highly transparent (up to 92% light transmittance) wood composites have been developed. The process of fabricating the transparent wood composites includes lignin removal followed by index-matching polymer infiltration resulted in fabrication of the transparent wood composites with preserved naturally aligned nanoscale fibers. The thickness of the transparent wood composite can be tailored by controlling the thickness of the initial wood substrate. The optical transmittance can be tailored by selecting infiltrating polymers with different refractive indices. The transparent wood composites have a range of applications in biodegradable electronics, optoelectronics, as well as structural and energy efficient building materials. By coating the transparent wood composite layer on the surface of GaAs thin film solar cell, an 18% enhancement in the overall energy conversion efficiency has been attained. |
| FILED | Monday, May 02, 2022 |
| APPL NO | 17/734283 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Processes, Apparatus or Selection of Substances for Impregnating, Staining, Dyeing, Bleaching of Wood or Similar Materials, or Treating of Wood or Similar Materials With Permeant Liquids, Not Otherwise Provided for; Chemical or Physical Treatment of Cork, Cane, Reed, Straw or Similar Materials B27K 3/15 (20130101) B27K 3/0207 (20130101) B27K 2240/10 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/26 (20130101) C08J 9/42 (20130101) C08J 2201/0422 (20130101) C08J 2301/02 (20130101) Compositions of Macromolecular Compounds C08L 1/02 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/184 (20130101) H01L 31/0304 (20130101) H01L 31/02168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168798 | Eberhart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integenx Inc. (Pleasanton, California) |
| ASSIGNEE(S) | INTEGENX. INC. (Pleasanton, California) |
| INVENTOR(S) | David Eberhart (Santa Clara, California); Yuan Li (Dublin, California); James Ogg (Sunnyvale, California); Ezra Van Gelder (Palo Alto, California); Stephen J. Williams (San Carlos, California); Timothy Woudenberg (San Francisco, California); Dean S. Burgi (Sunnyvale, California); William D. Nielsen (San Jose, California) |
| ABSTRACT | This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119874 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/5029 (20130101) B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2200/04 (20130101) B01L 2200/025 (20130101) B01L 2200/028 (20130101) B01L 2200/143 (20130101) B01L 2200/0647 (20130101) B01L 2200/0684 (20130101) B01L 2300/023 (20130101) B01L 2300/027 (20130101) B01L 2300/123 (20130101) B01L 2300/0672 (20130101) B01L 2400/043 (20130101) B01L 2400/0421 (20130101) B01L 2400/0478 (20130101) B01L 2400/0616 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 2565/629 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44704 (20130101) G01N 2035/00158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168954 | Buchanan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Gregory Buchanan (King George, Virginia); Vincent J. Vendetti (King George, Virginia) |
| ASSIGNEE(S) | USA as rep by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | William Gregory Buchanan (King George, Virginia); Vincent J. Vendetti (King George, Virginia) |
| ABSTRACT | A rotary engine is provided to produce torque. The engine includes a planar housing, an elongated rotor, a pair of double-concave blades, fore and aft cover plates, and a gear box. The housing has a circular center cavity, and a pair of circular lateral cavities overlapping the center cavity and disposed along a longitudinal axis. The rotor is disposed on a rotor shaft along a rotation axis perpendicular to the longitudinal axis within the center cavity. The blades flank the rotor and are disposed within their corresponding lateral cavity and turn on corresponding blade shafts parallel to the rotor shaft. The blades flank the rotor disposed within their corresponding lateral cavity and turn on corresponding blade shafts parallel to the rotor shaft. The fore and aft cover plates flank the housing along the rotation axis to cover the center and lateral cavities. The gear box is disposed on the aft cover plate and has a rotor gear wheel with adjacent corresponding blade gear wheels. The rotor gear wheel turns with the rotor shaft while engaging both blade gear wheels along their peripheries. The blade gear wheels turn with the corresponding blade shafts. The blades turn opposite to the rotor. |
| FILED | Thursday, March 26, 2020 |
| APPL NO | 16/831023 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Rotary-piston or Oscillating-piston Machines or Engines F01C 1/22 (20130101) Cyclically Operating Valves for Machines or Engines F01L 1/18 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 53/00 (20130101) F02B 53/04 (20130101) F02B 53/06 (20130101) F02B 53/12 (20130101) Original (OR) Class F02B 55/00 (20130101) F02B 55/02 (20130101) F02B 55/08 (20130101) F02B 55/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168983 | Heeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana); Rolls-Royce Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | Robert W. Heeter (Indianapolis, Indiana); Daniel E. Molnar, Jr. (Indianapolis, Indiana); Jonathan M. Rivers (Indianapolis, Indiana) |
| ABSTRACT | A gas turbine engine includes a fan and a fan case assembly. The fan includes a fan rotor configured to rotate about an axis of the gas turbine engine and a plurality of fan blades coupled to the fan rotor for rotation therewith. The fan case assembly extends circumferentially around the plurality of fan blades radially outward of the plurality of the fan blades. |
| FILED | Friday, June 28, 2024 |
| APPL NO | 18/759050 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/08 (20130101) F01D 11/22 (20130101) Non-positive-displacement Pumps F04D 27/0215 (20130101) Original (OR) Class F04D 29/526 (20130101) F04D 29/685 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169209 | Grinolds et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. Grinolds (Cambridge, Massachusetts); Sungkun Hong (Cambridge, Massachusetts); Patrick Maletinsky (Cambridge, Massachusetts); Amir Yacoby (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485478 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) G01N 2201/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/08 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/323 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169792 | Vega et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Augusto Vega (Mount Vernon, New York); Pradip Bose (Yorktown Heights, New York); Alper Buyuktosunoglu (White Plains, New York) |
| ABSTRACT | In a first device, a local classification and a local classification confidence score corresponding to an event input are computed. At the first device in response to a broadcast request, a remote classification and a remote classification confidence score corresponding to the event input are received, the remote classification and the remote classification confidence score being computed at a second device. At the first device, a consensus classification including the most frequent classification from a set of all received remote classifications and the local classification is formed, provided the number of classifications including the most frequent classification exceeds a threshold. In response to a consensus classification confidence score corresponding to the consensus classification exceeding a confidence threshold, a local classification model is updated. Based on the local classification and the consensus classification, the event input is assigned to a classification. |
| FILED | Friday, June 22, 2018 |
| APPL NO | 16/015986 |
| ART UNIT | 2125 — AI & Simulation/Modeling |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) Original (OR) Class G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1458 (20130101) H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169793 | Wright et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| INVENTOR(S) | Robert Wright (Sherrill, New York); Lei Yu (Vestal, New York); Steven Loscalzo (Vienna, Virginia) |
| ABSTRACT | A system and method for controlling a system, comprising estimating an optimal control policy for the system; receiving data representing sequential states and associated trajectories of the system, comprising off-policy states and associated off-policy trajectories; improving the estimate of the optimal control policy by performing at least one approximate value iteration, comprising: estimating a value of operation of the system dependent on the estimated optimal control policy; using a complex return of the received data, biased by the off-policy states, to determine a bound dependent on at least the off-policy trajectories, and using the bound to improve the estimate of the value of operation of the system according to the estimated optimal control policy; and updating the estimate of the optimimal control policy, dependent on the improved estimate of the value of operation of the system. The control system may produce an output signal to control the system directly, or output the optimized control policy. The system preferably is a reinforcement learning system which continually improves. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099762 |
| ART UNIT | 2125 — AI & Simulation/Modeling |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/0265 (20130101) G05B 15/02 (20130101) Computer Systems Based on Specific Computational Models G06N 7/01 (20230101) Original (OR) Class G06N 20/00 (20190101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 10/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170025 | Al-Husseini |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the State (Washington, District of Columbia) |
| INVENTOR(S) | Mahdi Al-Husseini (Douglasville, Georgia) |
| ABSTRACT | Disclosed are systems and associated methods for calculating and displaying formation flight information, to include aircraft spacing, predicted trajectory data, collision avoidance alerts, time on target details, and chalk-specific information, on an augmented reality display designed to interface with aviation helmets. Two or more networked computing devices, each on a separate aircraft, collect some combination of aircraft altitude, location, and inertial data, preform certain calculations, and then develops a virtual overlay according to aircraft relative position and nearby aircraft trajectories. The virtual overlay is further informed by compass and gyroscopic data from an operatively coupled augmented reality display device. The developed virtual overlay is then transmitted to the display device for viewing by the pilot. The display of relevant formation flight information using augmented reality tools may result in improved formation flight spacing, emergency procedure response, and collision avoidance. |
| FILED | Tuesday, January 17, 2023 |
| APPL NO | 18/097669 |
| ART UNIT | 3655 — Material and Article Handling |
| CURRENT CPC | Electric Digital Data Processing G06F 3/012 (20130101) Image Data Processing or Generation, in General G06T 11/00 (20130101) Traffic Control Systems G08G 5/0008 (20130101) G08G 5/0021 (20130101) Original (OR) Class G08G 5/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170718 | Micciancio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| ASSIGNEE(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| INVENTOR(S) | Daniele Micciancio (San Diego, California); Yuriy Polyakov (Fair Lawn, New Jersey); Zeyu Liu (Long Island City, New York) |
| ABSTRACT | Systems and methods for improving homomorphic encryption are provided. A processor receives an encrypted ciphertext; splits the encrypted ciphertext into a plurality of smaller digits; applies a homomorphic floor function to clear a least significant bit from a current smaller digit; scales down the encrypted ciphertext, using modulus switching, thereby changing the ciphertext modulus to a new modulus; applies a bootstrapping procedure for a sign evaluation function to determine a sign of the scaled down encrypted ciphertext; and transmits the sign with the ciphertext to a server for subsequent use. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958590 |
| ART UNIT | 2498 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 12168134 | Ince et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas) |
| INVENTOR(S) | Nuri F. Ince (Humble, Texas); Musa Ozturk (Houston, Texas); Ashwin Viswanathan (Houston, Texas) |
| ABSTRACT | A method of locating an implantation site in the brain includes inserting a plurality of multi-contact electrodes into a region of a target structure in an individual's brain. High Frequency Stimulation (HFS) is applied to a contact of a multi-contact electrode of the plurality of multi-contact electrodes. High Frequency Oscillations (HFO) evoked in the region of the target structure by the HFS are measured. Evoked Compound Activity (ECA) evoked in the region of the target structure by the HFS is measured. It is determined if at least one of the HFO and the ECA is above a predetermined threshold. If at least one of the HFO and the ECA is above the predetermined threshold, a location of the contact of the multi-contact electrode is identified as a site for electrode implantation in the individual's brain. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400306 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36067 (20130101) A61N 1/36171 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168202 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Maohong Fan (Ames, Iowa); Xiaowen Zhang (Laramie, Wyoming); Yangyan Gao (Laramie, Wyoming); Armistead G Russell (Atlanta, Georgia); Xin He (Laramie, Wyoming) |
| ABSTRACT | A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2−] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2−] for the reversible CO2 sorption and desorption. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049226 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Separation B01D 53/8671 (20130101) Original (OR) Class B01D 53/8693 (20130101) B01D 2257/504 (20130101) B01D 2259/816 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0278 (20130101) B01J 37/343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168232 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gongchen Sun (Atlanta, Georgia); Hang Lu (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a fluidic device comprising a substrate, an applicator, and a spacer. The substrate can comprise a plurality of wells. The applicator can be used for manipulating a biological substance in at least a portion of the plurality of wells. The spacer can be positioned between the substrate and the applicator. The spacer can be configured to allow the applicator to apply the biological substance to at least a portion of the plurality of wells while maintaining a space between the substrate and the applicator. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499515 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/0642 (20130101) B01L 2300/161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168614 | Garcia-Perez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Manuel Garcia-Perez (Richland, Washington); Michael A. A. Apasiku (Albuquerque, New Mexico); Sohrab Haghighi Mood (Pullman, Washington); Jean-Sabin McEwen (Pullman, Washington) |
| ABSTRACT | The present disclosure provides adsorbent compositions of carbon-containing material and nitrogen that are co-doped with a metal, such as magnesium or calcium. The disclosure also provides methods of adsorbing phosphate, as well as beneficial end products following the process of adsorption. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476891 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/04 (20130101) B01J 20/20 (20130101) B01J 20/0229 (20130101) B01J 20/0259 (20130101) B01J 2220/42 (20130101) B01J 2220/4831 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/283 (20130101) Original (OR) Class C02F 2101/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168619 | Alcantar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Norma Arcelia Alcantar (Tampa, Florida); Wen Zhao (Phoenix, Arizona) |
| ABSTRACT | Compositions, systems and methods of removing ammonia from fish storage systems are presented. A chemical water conditioner comprised of sodium formaldehyde bisulfite, cornstarch, dye and alcohol was found to have a high ammonia removal efficiency in seawater. A combination of this chemical water conditioner with modified chabazite and phosphate buffer exhibited high ammonia removal efficiency in both seawater and freshwater. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/068199 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/42 (20130101) Original (OR) Class C02F 2101/16 (20130101) C02F 2103/20 (20130101) C02F 2303/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168623 | Lin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | WEST VIRGINIA UNIVERSITY (Morgantown, West Virginia) |
| INVENTOR(S) | Lian-Shin Lin (Morgantown, West Virginia) |
| ABSTRACT | A method for treating wastewater comprising subjecting a sulfate containing wastewater to Fe(III) iron dosing in an anaerobic bioreactor containing one or more of an iron reducing bacteria and one or more of a sulfate reducing bacteria, and one or more of a fermentative bacteria, and adjusting a dosage of the Fe(III) iron in the anaerobic bioreactor to achieve a Fe/Sulfate molar ratio that is equal to or greater than 0.50, and removing an effluent from the anaerobic bioreactor that is a treated wastewater. A wastewater treatment system is provided having a wastewater reservoir, a ferric iron solution reservoir, an anaerobic bioreactor, and an effluent reservoir. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/753625 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/341 (20130101) Original (OR) Class C02F 3/345 (20130101) C02F 3/346 (20130101) C02F 3/2866 (20130101) C02F 2101/20 (20130101) C02F 2101/30 (20130101) C02F 2103/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168679 | Bothfeld et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | William H. Bothfeld (Chicago, Illinois); Keith E. J. Tyo (Evanston, Illinois) |
| ABSTRACT | The present disclosure relates generally to modified bacteria, such as E. coli, with modification in the expression of at least one gene encoding a type I and/or type II toxin-antitoxin (TA) system protein and/or at least one gene encoding a structural protein that modulates ribosomes and methods of using the disclosed bacteria for producing a biological compound of interest. The modifications of the bacteria result in enhanced bioproduction. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522441 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/245 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) C12P 7/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168797 | Kartalov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Emil P. Kartalov (Pasadena, California); Aditya Rajagopal (Orange, California); Axel Scherer (Barnard, Vermont) |
| ABSTRACT | This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte. |
| FILED | Thursday, July 13, 2023 |
| APPL NO | 18/352112 |
| ART UNIT | 1672 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6825 (20130101) Original (OR) Class C12Q 1/6851 (20130101) C12Q 1/6851 (20130101) C12Q 2537/101 (20130101) C12Q 2537/143 (20130101) C12Q 2537/165 (20130101) C12Q 2563/107 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) Electric Digital Data Processing G06F 17/10 (20130101) G06F 17/11 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 25/00 (20190201) G16B 25/20 (20190201) G16B 40/00 (20190201) G16B 40/10 (20190201) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170567 | McCormick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Jackson McCormick (Atlanta, Georgia); Morris Cohen (Atlanta, Georgia) |
| ABSTRACT | An embodiment of the disclosure provides a method of generating an electron density map of a D-region of the ionsphere. The method can comprise: defining a plurality of grid pixels corresponding to a portion of the D-region of the ionosphere; receiving a plurality of electromagnetic signals, each of the plurality of electromagnetic signals having propagated along a distinct propagation path through a portion of the D-region corresponding to one or more of the plurality of grid pixels; clustering the plurality of electromagnetic signals based on similarities in a point-of-origin of the plurality of electromagnetic signals; determining a path-averaged electron density curve for each of the plurality of clustered signals; determining a basis representation of an electron density curve of the plurality of grid pixels, which is consistent with the path-averaged electron density curves; and generating, based on the basis representation, an electron density map for the D-region of the ionosphere. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/786603 |
| ART UNIT | 3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/007 (20130101) Transmission H04B 7/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170718 | Micciancio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| ASSIGNEE(S) | Duality Technologies, Inc. (Maplewood, New Jersey) |
| INVENTOR(S) | Daniele Micciancio (San Diego, California); Yuriy Polyakov (Fair Lawn, New Jersey); Zeyu Liu (Long Island City, New York) |
| ABSTRACT | Systems and methods for improving homomorphic encryption are provided. A processor receives an encrypted ciphertext; splits the encrypted ciphertext into a plurality of smaller digits; applies a homomorphic floor function to clear a least significant bit from a current smaller digit; scales down the encrypted ciphertext, using modulus switching, thereby changing the ciphertext modulus to a new modulus; applies a bootstrapping procedure for a sign evaluation function to determine a sign of the scaled down encrypted ciphertext; and transmits the sign with the ciphertext to a server for subsequent use. |
| FILED | Monday, October 03, 2022 |
| APPL NO | 17/958590 |
| ART UNIT | 2498 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/008 (20130101) Original (OR) Class H04L 9/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 12168661 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Jian Li (Tempe, Arizona); Xinqiang Tan (Tempe, Arizona) |
| ABSTRACT | A series of novel donor-acceptor type TADF luminogens have been designed with the aim of developing stable OLEDs with enhanced operational stability and improved color purity. These materials can be utilized in full color displays and lighting applications. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178901 |
| ART UNIT | 1789 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Heterocyclic Compounds C07D 471/22 (20130101) Original (OR) Class Organic electric solid-state devices H10K 50/11 (20230201) H10K 85/657 (20230201) H10K 85/6572 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168685 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R. M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Tuesday, October 18, 2022 |
| APPL NO | 18/047533 |
| ART UNIT | 1675 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 47/6891 (20170801) A61K 47/68031 (20230801) A61K 47/68033 (20230801) A61K 49/0008 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/1037 (20130101) C12N 2810/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168819 | Pathak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Arjun K. Pathak (Willamsville, New York); Yaroslav Mudryk (Ames, Iowa); Oleksandr Dolotko (Karlsruhe, Germany); Vitalij K. Pecharsky (Ames, Iowa) |
| ABSTRACT | A magnetocaloric material comprising a La—Fe—Si based alloy composition that is compositionally modified to include a small but effective amount of at least one of Al, Ga, and In to improve mechanical stability of the alloy (substantially reduce alloy brittleness), improve thermal conductivity, and preserve comparable or provide improved magnetocaloric effects. The alloy composition may be further modified by inclusion of at least one of Co, Mn, Cr, and V as well as interstitial hydrogen. |
| FILED | Wednesday, February 16, 2022 |
| APPL NO | 17/803110 |
| ART UNIT | 1734 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Alloys C22C 33/04 (20130101) Original (OR) Class C22C 38/02 (20130101) C22C 38/005 (20130101) C22C 38/06 (20130101) C22C 2202/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168922 | Dahi Taleghani |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Arash Dahi Taleghani (University Park, Pennsylvania) |
| ABSTRACT | Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363003 |
| ART UNIT | 3674 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/80 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/267 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12168968 | Zuo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Lei Zuo (Blacksburg, Virginia); Robert Parker (Salt Lake City, Utah); Xiaofan Li (Blacksburg, Virginia) |
| ABSTRACT | Various examples of simultaneous ocean wave and current energy harvesting are described, using a hybrid ocean energy converter and a mechanical transfer system therefor. In one example, a hybrid ocean energy converter includes a two-body point absorber comprising a first body and a second body. The two-body point absorber can be configured to transfer a linear relative motion between the first body and the second body to bi-directional rotation of a first input shaft. A turbine can be configured rotate a second input shaft. The converter further includes a hybrid power takeoff including a mechanical transfer system configured to mechanically couple the first input shaft, the second input shaft, an output shaft, and an output shaft. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/784187 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/10 (20130101) F03B 13/12 (20130101) F03B 13/16 (20130101) F03B 13/22 (20130101) Original (OR) Class F03B 13/26 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2260/40 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 1/00 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169920 | Brannigan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Eric Michael Brannigan (Lenexa, Kansas); Benjamin Ross Brown (Lee's Summit, Missouri) |
| ABSTRACT | A method of detecting a deformation in a lattice structure comprises capturing first image data of the lattice structure via a first image capturing device with a first telecentric lens and a second image capturing device with a second telecentric lens. The first telecentric lens is directed toward the lattice structure, and the second telecentric lens is spaced apart from the first telecentric lens and also directed toward the lattice structure. The method includes compressing the lattice structure; capturing second image data of the lattice structure via the first and second image capturing devices; and detecting the deformation based at least in part on the first and second image data. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568861 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0033 (20130101) G01M 5/0091 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 23/90 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169962 | Martinez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Carianne Martinez (Albuquerque, New Mexico); Kevin Matthew Potter (Albuquerque, New Mexico); Emily Donahue (Albuquerque, New Mexico); Matthew David Smith (Albuquerque, New Mexico); Charles J. Snider (Albuquerque, New Mexico); John P. Korbin (Albuquerque, New Mexico); Scott Alan Roberts (Albuquerque, New Mexico); Lincoln Collins (Albuquerque, New Mexico) |
| ABSTRACT | Digital image segmentation is provided. The method comprises training a neural network for image segmentation with a labeled training dataset from a first domain, wherein a subset of nodes in the neural net are dropped out during training. The neural network receives image data from a second, different domain. A vector of N values that sum to 1 is calculated for each image element, wherein each value represents an image segmentation class. A label is assigned to each image element according to the class with the highest value in the vector. Multiple inferences are performed with active dropout layers for each image element, and an uncertainty value is generated for each image element. Uncertainty is resolved according to expected characteristics. The label of any image element with an uncertainty above a threshold is replaced with a new label corresponding to a segmentation class based on domain knowledge. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832477 |
| ART UNIT | 2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/776 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170330 | Conway et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Adam Conway (Livermore, California); Sara Elizabeth Harrison (Fremont, California); Rebecca Nikolic (Oakland, California); Qinghui Shao (Fremont, California); Lars Voss (Livermore, California) |
| ABSTRACT | An apparatus includes at least one vertical transistor, where the at least one vertical transistor includes: a substrate including a first semiconductor material, an array of three dimensional (3D) structures above the substrate, a sidewall heterojunction layer positioned on at least one vertical sidewall of each 3D structure, and an isolation region positioned between the 3D structures. Each 3D structure includes the first semiconductor material. The sidewall heterojunction layer includes a second semiconductor material, where the first and second semiconductor material have different bandgaps. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/238012 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/2003 (20130101) H01L 29/7788 (20130101) H01L 29/7789 (20130101) H01L 29/7827 (20130101) Original (OR) Class H01L 29/8083 (20130101) H01L 29/66924 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12170441 | Piesciorovsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Emilio C. Piesciorovsky (Oak Ridge, Tennessee); Travis M. Smith (Oak Ridge, Tennessee); Michael W. Marshall (Oak Ridge, Tennessee); Srijib K. Mukherjee (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for identifying pinout information for an IED and operable to test the IED in accordance with a power system. The pinout information for many IEDs is conventionally lacking, leading to conventional testing systems that utilize amplifiers in order to generate the actual current and voltage levels of a power system for simulating the power system in conjunction with one or more IEDs. A system and method are provided to identify pinouts of an IED that can be utilized for simulating the power system with an IED without the need to generate actual current and voltage levels of the power system. |
| FILED | Monday, December 13, 2021 |
| APPL NO | 17/548744 |
| ART UNIT | 2116 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2639 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00001 (20200101) H02J 13/00002 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 12168614 | Garcia-Perez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Manuel Garcia-Perez (Richland, Washington); Michael A. A. Apasiku (Albuquerque, New Mexico); Sohrab Haghighi Mood (Pullman, Washington); Jean-Sabin McEwen (Pullman, Washington) |
| ABSTRACT | The present disclosure provides adsorbent compositions of carbon-containing material and nitrogen that are co-doped with a metal, such as magnesium or calcium. The disclosure also provides methods of adsorbing phosphate, as well as beneficial end products following the process of adsorption. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476891 |
| ART UNIT | 1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/04 (20130101) B01J 20/20 (20130101) B01J 20/0229 (20130101) B01J 20/0259 (20130101) B01J 2220/42 (20130101) B01J 2220/4831 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/283 (20130101) Original (OR) Class C02F 2101/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US PP36320 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
| INVENTOR(S) | Patrick P. Moore (Pullman, Washington); Wendy Hoashi-Erhardt (Pullman, Washington) |
| ABSTRACT | This invention relates to a new and distinct variety of red raspberry plant (Rubus idaeus L.) named ‘WSU 2188’ from a controlled cross of two unnamed WSU raspberry selections that is different from its parents and other mid-season raspberries. ‘WSU 2188’ is primarily characterized by suitability for machine harvestability, adapted to the raspberry production area of the Pacific Northwest tolerance to root rot, mid-season production and large, conical fruit. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/445560 |
| ART UNIT | 1661 — Plants |
| CURRENT CPC | Plants PLT/204 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 12169141 | Williams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| INVENTOR(S) | Paul Andrew Williams (Erie, Colorado); Daniel Rahn (El Segundo, California); Anna Katariina Vaskuri (Boulder, Colorado) |
| ABSTRACT | A gravity-enforced photon momentum radiometer incudes: a magnetic array; a diamagnetic shuttle that levitates above the magnetic array; a mirror on the diamagnetic shuttle that receives laser light and moves the diamagnetic shuttle due to the optical force; a tiltable platform for the magnetic array; a photogate producing gate light that can be blocked by a photo interrupter and that produces a detector signal that provides a position of the diamagnetic shuttle relative to the tiltable platform for determining a position of the diamagnetic shuttle relative to the photogate. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831736 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/08 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/0403 (20130101) G01J 1/0414 (20130101) G01J 1/4257 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169209 | Grinolds et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Michael S. Grinolds (Cambridge, Massachusetts); Sungkun Hong (Cambridge, Massachusetts); Patrick Maletinsky (Cambridge, Massachusetts); Amir Yacoby (Cambridge, Massachusetts) |
| ABSTRACT | A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485478 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/645 (20130101) G01N 24/10 (20130101) G01N 2201/10 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/025 (20130101) G01Q 60/08 (20130101) G01Q 60/38 (20130101) G01Q 60/54 (20130101) G01Q 70/14 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/022 (20130101) G01R 33/032 (20130101) G01R 33/60 (20130101) G01R 33/323 (20130101) G01R 33/1284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 12169485 | Bentley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Daniel M. Bentley (Washington, District of Columbia); Robert E. Dixon, Jr. (Washington, District of Columbia); Ryan M. Luckay (Washington, District of Columbia) |
| ABSTRACT | A method and system of providing material based on a user-initiated request utilizing an electronic database includes receiving search keywords to conduct a search and accessing a first database having previously stored contact information for the particular user in an initial table record. The method includes transforming data in the fields of the record for the particular user in the initial table to generate a record in a sanitized table, accessing a second electronic database having previously stored data structures corresponding to businesses, where each data structure maps selected keyword combinations to corresponding icons, and to particular material corresponding to each keyword combination, and displaying icons associated with search results having corresponding selected keywords near associated result items on an electronic display. The method includes initiating sending of particular material corresponding to the request based on the selected icon and contact data for the user obtained from the sanitized table. |
| FILED | Thursday, July 27, 2023 |
| APPL NO | 18/360620 |
| ART UNIT | 2162 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0481 (20130101) G06F 3/04817 (20130101) G06F 3/04842 (20130101) G06F 16/2282 (20190101) Original (OR) Class G06F 16/2379 (20190101) G06F 16/9535 (20190101) G06F 21/42 (20130101) G06F 21/6227 (20130101) G06F 21/6245 (20130101) G06F 21/6254 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/107 (20130101) G06Q 50/01 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/01 (20220501) H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12169757 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system and a method for extracting a computer readable code from a captured image of a mailpiece or parcel using downsampling and edge detection. The system can include a reader configured to capture an image of an item having a computer readable code positioned thereon and a processor in data communication with the reader. The processor can generate captured image data of the item including the computer readable code, downconvert the captured image data to generate a downconverted image data and detect an edge of the computer readable code. The processor can also identify a position of the computer readable code in the downconverted image data and store or process only the identified computer readable code. |
| FILED | Thursday, July 20, 2023 |
| APPL NO | 18/355673 |
| ART UNIT | 2876 — Optics |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1443 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 3/4023 (20130101) G06T 7/13 (20170101) G06T 7/73 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 12167919 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Quan Zhang (Winchester, Massachusetts); Gary Strangman (Boxford, Massachusetts) |
| ABSTRACT | A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. A perturbation unit provide an optical perturbation to the one or more superficial biological layers. An optical signal generator transmits optical signals at one or more near-infrared wavelengths. An optical signal receiver acquires a set of optical signal data preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation. A signal processor determines, using the set of optical signal data, a set of optical characteristics and separates, using the set of optical characteristics, a target optical signal. The signal processor generates a report indicative of a movement of the targeted biological tissue within the subject. The movement of the targeted biological layer is calculated using the target optical signal. |
| FILED | Wednesday, December 13, 2023 |
| APPL NO | 18/538583 |
| ART UNIT | 3798 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6814 (20130101) A61B 5/14553 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 17, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20241217.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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