FedInvent™ Patents
Patent Details for Tuesday, December 24, 2024
This page was updated on Wednesday, December 25, 2024 at 07:18 PM GMT
Department of Health and Human Services (HHS)
| US 12171524 | Wax et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| INVENTOR(S) | Adam Wax (Durham, North Carolina); Nicholas Shaheen (Durham, North Carolina); Kengyeh Chu (Durham, North Carolina); Derek Ho (Durham, North Carolina); Zachary Steelman (Durham, North Carolina) |
| ABSTRACT | Systems and methods for multi-modal imaging using an endoscope having an instrument channel, where the imaging is achieved without using the channel, are disclosed. The systems can include a multi-modal imaging paddle housing couple to a distal end of the endoscope. The housing can receive at least two imaging probes. The imaging probes can be an angle-resolved low-coherence interferometry probe (a/LCI) and an optical coherence tomography (OCT) probe. The housing can be scaled and positioned to be visible via the endoscope camera. The system and method can include locating the housing in a region of interest using the endoscope camera, acquiring OCT measurements to identify targets, and then acquiring a/LCI measurements at the identified targets. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589333 |
| ART UNIT | 3797 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) A61B 1/07 (20130101) A61B 1/018 (20130101) A61B 1/0638 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 10/04 (20130101) A61B 18/14 (20130101) A61B 2018/00577 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171529 | Ertin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Emre Ertin (Columbus, Ohio); William T. Abraham (Columbus, Ohio) |
| ABSTRACT | Various examples related to mobile bodily monitoring using ultra-wideband radar are provided. In one example, a method for determining a bodily characteristic includes collecting sets of reflected backscatter data for a sequence of ultra-wideband (UWB) pulses transmitted via an UWB sensor, and a corresponding calibration measurement from a calibration channel; determining reflection coefficients for each tissue interface based on the sets of reflected backscatter data; and determining a fluid level content of the lung tissue based upon the reflection coefficients. The reflection coefficients can be determined from reflection profiles based upon the reflected backscatter data for that sequence of UWB pulses and the corresponding calibration measurement. The UWB sensor can include an array of transmit (TX) and receive (RX) antenna pairs positioned on a body of a user. The reflection profile can be associated with a model of tissue layers in the body between the UWB sensor and lung tissue. |
| FILED | Wednesday, July 17, 2019 |
| APPL NO | 17/260827 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/07 (20130101) A61B 5/0205 (20130101) Original (OR) Class A61B 5/0507 (20130101) A61B 5/0537 (20130101) A61B 5/6833 (20130101) A61B 2560/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171546 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Xuezhu Zhang (Davis, California); Jinyi Qi (Davis, Canada); Simon R. Cherry (Davis, California); Ramsey D. Badawi (Sacramento, California); Guobao Wang (Sacramento, California) |
| ABSTRACT | The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/619471 |
| ART UNIT | 2632 — Digital Communications |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/113 (20130101) A61B 5/1128 (20130101) Original (OR) Class A61B 5/02755 (20130101) A61B 5/7289 (20130101) A61B 6/037 (20130101) A61B 6/486 (20130101) Measurement of Nuclear or X-radiation G01T 1/2985 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171731 | Koeberl et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); National University of Singapore (Singapore, Singapore) |
| INVENTOR(S) | Dwight D. Koeberl (Durham, North Carolina); Paul M. Yen (Singapore, Singapore); Benjamin L. Farah (Rocky River, Ohio) |
| ABSTRACT | The present disclosure is directed to methods of treating a steatosis- associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage. |
| FILED | Monday, May 22, 2023 |
| APPL NO | 18/200557 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/55 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/155 (20130101) A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/198 (20130101) A61K 31/216 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/355 (20130101) A61K 31/385 (20130101) A61K 31/436 (20130101) A61K 31/519 (20130101) A61K 31/522 (20130101) A61K 31/575 (20130101) A61K 31/5415 (20130101) A61K 31/7016 (20130101) A61K 33/00 (20130101) A61K 38/47 (20130101) A61K 38/47 (20130101) A61K 38/465 (20130101) A61K 38/465 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Enzymes C12Y 301/04012 (20130101) C12Y 302/0102 (20130101) C12Y 302/01022 (20130101) C12Y 302/01045 (20130101) C12Y 302/01049 (20130101) C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171740 | Azouz et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| INVENTOR(S) | Nurit P. Azouz (Cincinnati, Ohio); Marc E. Rothenberg (Cincinnati, Ohio) |
| ABSTRACT | Provided are methods for increasing SPINK7 anti-proteinase activity in a target tissue of a subject having an allergic inflammatory condition characterized by inflammation of a squamous epithelium in the target tissue, the method comprising inhibiting kallikrein 5 (KLK5) proteinase activity in the target tissue. Suitable KLK5 inhibitors may include a KLK5-Fc fusion protein, a KLK5 anti-sense polynucleotide, a KLK5-directed miRNA, a KLK5-directed shRNA, a KLK5-directed antibody, or a coumarin compound such as 3-(3-chlorophenyl) carboxy-7-hydroxymethyl coumarin or 3-carboxy-7-hydroxymethyl coumarin. |
| FILED | Tuesday, December 13, 2022 |
| APPL NO | 18/080057 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/37 (20130101) Original (OR) Class A61K 31/352 (20130101) A61K 31/711 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 38/005 (20130101) A61K 38/55 (20130101) A61K 38/57 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171755 | Agarwal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Suneet Agarwal (Lexington, Massachusetts); Neha Nagpal (Boston, Massachusetts); Yick Fong (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure relates to compounds that are, e.g., PAP Associated Domain Containing 5 (PAPD5) inhibitors and methods of use thereof. |
| FILED | Thursday, October 25, 2018 |
| APPL NO | 16/758804 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/52 (20130101) A61K 31/53 (20130101) A61K 31/55 (20130101) A61K 31/341 (20130101) A61K 31/353 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) A61K 31/422 (20130101) A61K 31/428 (20130101) A61K 31/429 (20130101) A61K 31/433 (20130101) A61K 31/437 (20130101) A61K 31/472 (20130101) A61K 31/473 (20130101) A61K 31/496 (20130101) A61K 31/498 (20130101) A61K 31/499 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/538 (20130101) A61K 31/549 (20130101) A61K 31/551 (20130101) A61K 31/4025 (20130101) A61K 31/4162 (20130101) A61K 31/4178 (20130101) A61K 31/4188 (20130101) A61K 31/4245 (20130101) A61K 31/4365 (20130101) A61K 31/4375 (20130101) A61K 31/4706 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 31/4741 (20130101) A61K 31/4985 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) A61K 31/5415 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/90241 (20130101) G01N 2333/91245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171769 | Ashcraft et al. |
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| FUNDED BY |
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| APPLICANT(S) | BioMimetix JV, LLC (Englewood, Colorado); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | BioMimetix JV, LLC (Englewood, Colorado); Duke University (Durham, North Carolina) |
| INVENTOR(S) | Kathleen Ashcraft (Durham, North Carolina); Mark Dewhirst (Chapel Hill, North Carolina); Ines Batinic-Haberle (Durham, North Carolina); James D. Crapo (Englewood, Colorado) |
| ABSTRACT | Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/691764 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/555 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171773 | Morrow et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio); The General Hospital Corporation (Boston, Massachusetts); Instituto Nacional de Ciencias Medicas Y Nutricion (Mexico City, Mexico) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnati, Ohio); The General Hospital Corporation (Boston, Massachusetts); Instituto Nacional de Ciencias. Medicas Y Nutricion (Mexico City, Mexico) |
| INVENTOR(S) | Ardythe L. Morrow (Cincinnatti, Ohio); David S. Newburg (Newtonville, Massachusetts); Guillermo M. Ruiz-Palacios (Mexico City, Mexico) |
| ABSTRACT | A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides. |
| FILED | Wednesday, May 04, 2022 |
| APPL NO | 17/736468 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/702 (20130101) A61K 31/7016 (20130101) Original (OR) Class A61K 35/20 (20130101) A61K 47/50 (20170801) A61K 47/61 (20170801) A61K 47/62 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171783 | Suva et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Mario Suva (Boston, Massachusetts); Bradley Bernstein (Boston, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Mariella Filbin (Boston, Massachusetts); Itay Tirosh (Cambridge, Massachusetts); Volker Hovestadt (Boston, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to compositions and methods for treating diffuse gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-gliomas). Disclosed herein are gene signatures specific for tumor cell types and compositions for treatment of H3K27M gliomas. In one embodiment, PRC1 is targeted in a treatment regimen for H3K27M-gliomas. |
| FILED | Tuesday, November 13, 2018 |
| APPL NO | 16/763705 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 38/50 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) C07K 16/3053 (20130101) C07K 2317/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171786 | Arzi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Boaz Arzi (Davis, California); Emily Mills Ko (Davis, California); Dori L Borjesson (David, California) |
| ABSTRACT | Provided are methods of determining whether a mammalian subject having an inflammatory condition (e.g., an oral inflammatory condition) will respond positively to mesenchymal stem cell (MSC) therapy, as well as method of treating such inflammatory conditions by administering MSCs. |
| FILED | Wednesday, October 05, 2016 |
| APPL NO | 15/765622 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0667 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5047 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171802 | Medved et al. |
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| FUNDED BY |
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| APPLICANT(S) | Leonid V. Medved (Ellicott City, Maryland); Dudley Strickland (Brookeville, Maryland); Sergiy Yakovlev (Rockville, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Leonid V. Medved (Ellicott City, Maryland); Dudley Strickland (Brookeville, Maryland); Sergiy Yakovlev (Rockville, Maryland) |
| ABSTRACT | The invention provides a method of treating inflammation, comprising administering to a subject in need thereof a therapeutically effective amount of an agent that inhibits binding of fibrin to Very Low Density Lipoprotein Receptor (VLDLR) or combination of this agent with agents inhibiting binding of fibrin to VE-cahherin (vascular endothelial cadherin). |
| FILED | Friday, June 02, 2017 |
| APPL NO | 16/306824 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/363 (20130101) A61K 38/363 (20130101) A61K 38/1774 (20130101) Original (OR) Class A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 37/06 (20180101) Peptides C07K 16/28 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171818 | Tran et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Rockville, Maryland); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195072 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171821 | Knoll et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| INVENTOR(S) | Laura Knoll (Madison, Wisconsin); Bruno Martorelli Di Genova (Madison, Wisconsin) |
| ABSTRACT | Methods of preparing mammalian enteroids, and methods producing T. gondii oocysts in vitro and in vivo in heterologous systems, are provided. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251121 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 39/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171822 | Eappen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | Sanaria Inc. (Rockville, Maryland) |
| INVENTOR(S) | Abraham G. Eappen (Ellicott City, Maryland); Stephen L. Hoffman (Gaithersburg, Maryland) |
| ABSTRACT | The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532731 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/52 (20130101) A61K 2039/522 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171834 | Lang et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| INVENTOR(S) | Bradley T. Lang (Cleveland, Ohio); Jared M. Cregg (Cleveland, Ohio); Jerry Silver (Bay Village, Ohio); Yi-Lan Weng (Baltimore, Maryland) |
| ABSTRACT | A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans. |
| FILED | Tuesday, November 15, 2022 |
| APPL NO | 17/987137 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/162 (20130101) A61K 38/179 (20130101) A61K 47/42 (20130101) Original (OR) Class A61K 47/645 (20170801) A61K 2121/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171838 | Pei et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Dehua Pei (Columbus, Ohio); Marina Buyanova (Columbus, Ohio); Ziqing Qian (Wellesley, Massachusetts) |
| ABSTRACT | The present disclosure provides for polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a polyarginine peptide and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the polyarginine peptide. The present disclosure demonstrates that cCPPs conjugated to polyarginine peptides can be used to deliver nucleic acids to the cytosol of cells. |
| FILED | Tuesday, July 02, 2019 |
| APPL NO | 17/257224 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6455 (20170801) Original (OR) Class Peptides C07K 7/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171877 | Freeman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | William R. Freeman (Del Mar, California); Michael J. Sailor (La Jolla, California); Lingyun Cheng (San Diego, California) |
| ABSTRACT | This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics. |
| FILED | Thursday, February 07, 2019 |
| APPL NO | 16/270259 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 9/0051 (20130101) A61K 9/143 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 9/7007 (20130101) A61K 31/573 (20130101) A61K 31/7088 (20130101) A61K 38/482 (20130101) A61K 39/44 (20130101) A61K 39/395 (20130101) A61K 2039/54 (20130101) A61K 2039/505 (20130101) Enzymes C12Y 304/21073 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171884 | Nel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Xiangsheng Liu (Los Angeles, California) |
| ABSTRACT | A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384214 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1278 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5192 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/62 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171904 | Jongpaiboonkit et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRS Holdings LLC (Ann Arbor, Michigan) |
| ASSIGNEE(S) | TRS Holdings LLC (Ann Arbor, Michigan) |
| INVENTOR(S) | Leenaporn Jongpaiboonkit (Madison, Wisconsin); William L. Murphy (Madison, Wisconsin) |
| ABSTRACT | Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase. |
| FILED | Tuesday, August 25, 2020 |
| APPL NO | 17/002482 |
| ART UNIT | 1762 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4455 (20130101) A61F 2002/2817 (20130101) A61F 2002/3008 (20130101) A61F 2002/3092 (20130101) A61F 2002/4485 (20130101) A61F 2002/30011 (20130101) A61F 2002/30032 (20130101) A61F 2002/30056 (20130101) A61F 2002/30062 (20130101) A61F 2002/30064 (20130101) A61F 2002/30303 (20130101) A61F 2002/30578 (20130101) A61F 2002/30785 (20130101) A61F 2002/30789 (20130101) A61F 2002/30838 (20130101) A61F 2002/30878 (20130101) A61F 2002/30884 (20130101) A61F 2002/30892 (20130101) A61F 2002/30899 (20130101) A61F 2210/0004 (20130101) A61F 2310/00017 (20130101) A61F 2310/00023 (20130101) A61F 2310/00029 (20130101) A61F 2310/00089 (20130101) A61F 2310/0097 (20130101) A61F 2310/00113 (20130101) A61F 2310/00131 (20130101) A61F 2310/00149 (20130101) A61F 2310/00155 (20130101) A61F 2310/00293 (20130101) A61F 2310/00796 (20130101) A61F 2310/00976 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/30 (20130101) A61K 38/1825 (20130101) A61K 38/1841 (20130101) A61K 38/1858 (20130101) A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/32 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2400/18 (20130101) A61L 2420/02 (20130101) A61L 2420/06 (20130101) A61L 2430/02 (20130101) A61L 2430/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171999 | Risi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | Cochlear Limited (Macquarie University, Australia); University of Washington Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Frank Risi (Newtown, Australia); Colin Irwin (Nice, France); Jay T. Rubinstein (Seattle, Washington); Felipe Santos (Boston, Massachusetts); James O. Phillips (Seattle, Washington) |
| ABSTRACT | A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures. |
| FILED | Thursday, May 11, 2023 |
| APPL NO | 18/315679 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/361 (20130101) A61N 1/0526 (20130101) Original (OR) Class A61N 1/0551 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172003 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Marlan Hansen (Solon, Iowa); Christopher Kaufmann (Iowa City, Iowa) |
| ABSTRACT | The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561260 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0541 (20130101) Original (OR) Class A61N 1/36038 (20170801) Transmission H04B 5/79 (20240101) Electric solid-state devices not otherwise provided for H10N 30/20 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172029 | Vartanian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENT OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Garen V. Vartanian (Ann Arbor, Michigan); Kwoon Y. Wong (Ann Arbor, Michigan); Pei-Cheng Ku (Ann Arbor, Michigan); Scott A. Almburg (Redford Township, Michigan) |
| ABSTRACT | A light source and a method of generating a light using the light source is disclosed. The light source is configured to produce a plurality of distinct colors in generating the light, one of the distinct colors falling within a blue spectral light band. A light controller modulates the spectral light produced by the plurality of distinct colors. The modulation provides melanopsin contrast in order to increase melanopsin responsiveness of a subject exposed to the generated light and maintains the color temperature, color quality, and color constancy experienced by the subject in a lit viewing environment within an acceptable range. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669134 |
| ART UNIT | 3796 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0618 (20130101) Original (OR) Class A61N 5/0622 (20130101) A61N 2005/0626 (20130101) A61N 2005/0652 (20130101) A61N 2005/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172038 | Westendorf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (North Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) Original (OR) Class A61K 47/6841 (20170801) A61K 2039/54 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172161 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic system includes a fluid distribution network, and a fluid collection and sampling network; a plurality of fluidic modules fluidically coupled between the fluid distribution network and the fluid collection and sampling network in parallel; a systemic circulation and mixing reservoir; and a first pump, and a second pump, wherein the first pump is fluidically coupled between the systemic circulation and mixing reservoir and the fluid distribution network for withdrawing media from the systemic circulation and mixing reservoir and delivering the media to the fluid distribution network; and wherein the second pump is fluidically coupled between the fluid collection and sampling network and a sample vial for withdrawing effluent of the plurality of fluidic modules from the fluid collection and sampling network and delivering the effluent to one or more sample vials. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015782 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 2300/123 (20130101) B01L 2400/0481 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/06 (20130101) F04B 43/14 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) F16K 2099/0084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172166 | Adalsteinsson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Viktor A. Adalsteinsson (Wakefield, Massachusetts); Denis Loginov (Dorchester Center, Massachusetts); J. Christopher Love (Somerville, Massachusetts); Alan Stockdale (Providence, Rhode Island); Todd Gierahn (Brookline, Massachusetts) |
| ABSTRACT | Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990390 |
| ART UNIT | 1799 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50 (20130101) B01L 3/5085 (20130101) Original (OR) Class B01L 2300/12 (20130101) B01L 2300/0654 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) B01L 2300/0896 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/01 (20240101) G01N 15/1425 (20130101) G01N 15/1433 (20240101) G01N 33/4833 (20130101) G01N 35/00029 (20130101) G01N 35/00871 (20130101) G01N 2015/1006 (20130101) G01N 2035/00148 (20130101) Optical Elements, Systems, or Apparatus G02B 21/006 (20130101) G02B 21/06 (20130101) G02B 21/008 (20130101) G02B 21/16 (20130101) G02B 21/26 (20130101) Image or Video Recognition or Understanding G06V 20/695 (20220101) G06V 20/698 (20220101) Pictorial Communication, e.g Television H04N 23/56 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172948 | Koley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Dipankar Koley (Corvallis, Oregon); Partha Sarathi Sheet (Ann Arbor, Michigan) |
| ABSTRACT | Multifunctional dendritic molecular probes that selectively detect Cu2+ ions via potentiometric and fluorometric techniques with low detection limits are disclosed. The selective and reversible binding of the molecules with the Cu2+ ion was used to make solid-state microsensors by incorporating the molecular probes into the carbon-based membranes as an ionophore for Cu (II). |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525730 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 251/80 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/251 (20130101) G01N 21/643 (20130101) G01N 27/3335 (20130101) G01N 2021/6434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172974 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biohaven Pharmaceutical Holding Company Ltd. (New Haven, Connecticut); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Biohaven Pharmaceutical Holding Company Ltd. (New Haven, Connecticut); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Garry Robert Smith (Royersford, Pennsylvania); Allen B. Reitz (Lansdale, Pennsylvania); Mark McDonnell (Lansdale, Pennsylvania); Suzie Chen (Highland Park, New Jersey); Matthew D. Vera (Collegeville, Pennsylvania); Benjamin E Blass (Eagleville, Pennsylvania); Jeffrey Claude Pelletier (Lafayette Hill, Pennsylvania); Venkata N. Velvadapu (Philadelphia, Pennsylvania); Jay Edward Wrobel (Lawrenceville, New Jersey) |
| ABSTRACT | Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. |
| FILED | Thursday, September 08, 2022 |
| APPL NO | 17/940287 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 277/82 (20130101) Original (OR) Class C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173012 | Wood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR UNIVERSITY (Waco, Texas) |
| ASSIGNEE(S) | BAYLOR UNIVERSITY (Waco, Texas) |
| INVENTOR(S) | John L. Wood (Waco, Texas); Ke Kong (Rockville, Maryland); Kevin Gayler (Waco, Texas) |
| ABSTRACT | Equipotent indolocarbazole-derived analogs of staurosporine identified herein are prepared through C—H borylation chemistry. Functionality resides at C2 and C10 of the indolocarbazole aromatic region. Introducing functionality in this previously inaccessible region does not abrogate kinase activity and is shown to change the selectivity profile. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422175 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 498/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173018 | Burns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | VENATORX PHARMACEUTICALS, INC. (Malvern, Pennsylvania) |
| INVENTOR(S) | Christopher J. Burns (Malvern, Pennsylvania); Denis Daigle (Street, Maryland); Guo-Hua Chu (Exton, Pennsylvania); Jodie Hamrick (New Holland, Pennsylvania); Steven A. Boyd (Chester Springs, Pennsylvania); Allison L Zulli (Chesterbrook, Pennsylvania); Eugen F. Mesaros (Wallingford, Pennsylvania); Stephen M. Condon (Glenmoore, Pennsylvania); Robert E. Lee Trout (Collegeville, Pennsylvania); Cullen L. Myers (Exton, Pennsylvania); Zhenrong Xu (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173029 | Hostetler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Karl Y. Hostetler (La Jolla, California); James Beadle (La Jolla, California); Nadejda Valiaeva (La Jolla, California); Robert T. Schooley (La Jolla, California) |
| ABSTRACT | Compounds, including antiviral prodrugs, and pharmaceutical formulations including the compounds, which may be orally bioavailable or formulated for intramuscular injection. Methods for producing compounds, such as antiviral prodrugs. Methods for treating coronavirus and other RNA virus infection in mammals. Methods of producing a drug triphosphate. |
| FILED | Saturday, July 24, 2021 |
| APPL NO | 18/006330 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class C07H 9/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173032 | Patton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| INVENTOR(S) | John Thomas Patton (Bloomington, Indiana); Asha Ann Philip (Bloomington, Indiana) |
| ABSTRACT | Embodiments herein report compositions, methods, uses and manufacturing procedures for rotavirus constructs and immunogenic compositions thereof. Some embodiments concern compositions that include, but are not limited to, chimeric rotaviruses of use in immunogenic compositions against rotavirus infection as well as against other pathogenic virus infection in a subject. In certain embodiments, constructs of use herein can be generated and used where a rotavirus expression system further includes one or more nucleic acid molecules encoding one or more polypeptides of another pathogen (e.g. another enteric or mucosal pathogen). |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/259844 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/15 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2720/12321 (20130101) C12N 2720/12322 (20130101) C12N 2720/12334 (20130101) C12N 2720/12351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173037 | Barasch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Jonathan Barasch (New York, New York); Andong Qiu (Bronx, New York) |
| ABSTRACT | In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/093055 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173039 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kian-Huat Lim (St. Louis, Missouri); Paarth B. Dodhiawala (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Kian-Huat Lim (St. Louis, Missouri); Paarth B. Dodhiawala (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of targeting TPL2 kinase as a novel strategy to block oncogenic KRAS-driven signaling, detection of TPL2 mutations, and uses of TPL2 inhibiting agents alone or in combination with chemotherapy in subjects having TPL2- or RAS-associated cancer. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571275 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173045 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| INVENTOR(S) | Yukai He (Martinez, Georgia); Wei Zhu (Augusta, Georgia); Esteban Celis (Augusta, Georgia); Yibing Peng (Augusta, Georgia); Lan Wang (Augusta, Georgia) |
| ABSTRACT | T cell receptors that specifically recognize hAFP158 and methods of their use are provided. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353409 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173051 | Haynes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); MacroGenics, Inc. (Rockville, Maryland); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); MacroGenics, Inc. (Rockville, Maryland); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Barton F. Haynes (Durham, North Carolina); Guido Ferrari (Durham, North Carolina); Scott Koenig (Rockville, Maryland); Leslie S. Johnson (Rockville, Maryland); Chia-Ying Kao Lam (San Jose, California); Julia A. Sung (Chapel Hill, North Carolina); David M. Margolis (Chapel Hill, North Carolina); Liqin Liu (Germantown, Maryland); Jeffrey Lee Nordstrom (Olney, Maryland) |
| ABSTRACT | The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecule and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells within the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/890380 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/44 (20130101) C07K 16/283 (20130101) C07K 16/468 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 16/2803 (20130101) C07K 16/2809 (20130101) C07K 16/2812 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/72 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/626 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173052 | Diskin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Ron Diskin (Pasadena, California); Anthony P. West (Pasadena, California); Michel Nussenzweig (New York, New York); Pamela J. Bjorkman (La Canada, California) |
| ABSTRACT | Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500171 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/545 (20130101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/567 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) C12N 2740/16122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173061 | Shetty |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Sreerama Shetty (Tyler, Texas) |
| ABSTRACT | Methods for treating, reducing, ameliorating or inhibiting symptoms idiopathic pulmonary fibrosis (IPF) or interstitial pneumonia, comprising administering to a subject in need of an effective amount of a) multiple EGF-like-domains-9 (MEGF9) or a biologically active fragment thereof; b) uncoordinated receptor 5A (UNC5A) or a biologically active fragment thereof; c) dolichyl-phosphate beta-glucosyltransferase (ALG5) or a biologically active fragment thereof; d) a combination of two or three of a)-c); e) an antibody specifically binding to a); f) an antibody specifically binding to b); g) an antibody specifically binding to c); h) a combination of two or three of e)-g); or i) a combination of at least one of a)-c) and at least one of e)-g). Pharmaceutical compositions and processes for making and using the compositions are also disclosed. |
| FILED | Thursday, October 05, 2023 |
| APPL NO | 18/481529 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/22 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173066 | Blumberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Richard S. Blumberg (Weston, Massachusetts); Yu-Hwa Huang (Weston, Massachusetts); Amit Gandhi (Billerica, Massachusetts); Monica Bertagnolli (Newton, Massachusetts); Charles Yoon (Brookline, Massachusetts); Robert George Edward Holgate (Royston, United Kingdom); Arron Robert Hearn (Ely, United Kingdom); Susan Dana Jones (Boston, Massachusetts) |
| ABSTRACT | Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 17/311258 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/41 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173073 | Frenette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| INVENTOR(S) | Paul S. Frenette (Bronx, New York); Sandra Pinho (Bronx, New York); Qiaozhi Wei (Bronx, New York); Sung Kyun Lee (Bronx, New York) |
| ABSTRACT | Antibodies and antibody fragments that inhibit the activity of vascular cell adhesion molecule 1 (VCAM1) and/or macrophage erythroblast attacher (MAEA) are provided, along with formulations and kits comprising these antibodies and antibody fragments and the use of the disclosed compositions, formulations, and kits to treat cancers, sickle cell disease, and Polycythemia Vera. |
| FILED | Tuesday, December 27, 2022 |
| APPL NO | 18/146951 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) A61P 35/02 (20180101) Peptides C07K 16/18 (20130101) C07K 16/2821 (20130101) C07K 16/2836 (20130101) Original (OR) Class C07K 16/2878 (20130101) C07K 16/2896 (20130101) C07K 16/3061 (20130101) C07K 2317/51 (20130101) C07K 2317/76 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173085 | Meyer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Kathryn Meyer (Durham, North Carolina) |
| ABSTRACT | Provided herein are compositions and methods for detection of N6-methyladenosine (m6A) in ribonucleic acid (RNA). The provided compositions include fusion proteins that can be used to edit RNA and detect m6A residues. Also provided are nucleic acids, vectors, constructs, host cells, and transgenic animals that encode or express such fusions proteins. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/313048 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6876 (20130101) C12Q 2600/154 (20130101) Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173087 | Gillies et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); INTEZYNE TECHNOLOGIES INC. (Tampa, Florida); ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida); Intezyne Technologies Inc. (Tampa, Florida); Arizona Board of Regents on Behalf of The University of Arizona (Tuscon, Arizona); Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Robert J. Gillies (Tampa, Florida); David L. Morse (Tampa, Florida); Natalie M. Barkey (Tampa, Florida); Kevin N. Sill (Tampa, Florida); Josef Vagner (Tucson, Arizona); Narges K. Tafreshi (Tampa, Florida); Jonathan L. Sessler (Austin, Texas); Christian Preihs (Austin, Texas); Victor J. Hruby (Tucson, Arizona) |
| ABSTRACT | The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imagable contrast agent and/or anti-cancer agent) selectively to the tumor cell. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582368 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/34 (20130101) A61K 47/64 (20170801) A61K 47/6907 (20170801) A61K 49/0056 (20130101) A61K 49/101 (20130101) A61K 49/1809 (20130101) Peptides C07K 5/1024 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 14/68 (20130101) C07K 14/723 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173088 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| INVENTOR(S) | Guangshun Wang (Omaha, Nebraska); Biswajit Mishra (Omaha, Nebraska); Jayaram Lakshmaiah Narayana (Omaha, Nebraska) |
| ABSTRACT | Antimicrobial peptides and methods of use are provided. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/278532 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 31/16 (20130101) A61L 2300/25 (20130101) A61L 2300/406 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173090 | Schoenfisch et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Mona Jasmine R. Ahonen (Chapel Hill, North Carolina); Lei Yang (Carrboro, North Carolina); Haibao Jin (Carrboro, North Carolina); Evan Scott Feura (Carrboro, North Carolina); Sara Elizabeth Maloney (Chapel Hill, North Carolina) |
| ABSTRACT | Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/806323 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 31/717 (20130101) A61K 31/726 (20130101) A61K 31/728 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 2300/404 (20130101) Polysaccharides; Derivatives Thereof C08B 15/04 (20130101) Original (OR) Class C08B 37/0063 (20130101) C08B 37/0072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173095 | Scott et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | Timothy F. Scott (Ann Arbor, Michigan); Harry van der Laan (Ann Arbor, Michigan); Megan A. Cole (Ann Arbor, Michigan); Mark A. Burns (Ann Arbor, Michigan); Martin P. De Beer (Ann Arbor, Michigan); Zachary D. Pritchard (Ann Arbor, Michigan); Avi Bregman (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to polymerization and producing polymers and particularly, but not exclusively, to methods, systems, and compositions for producing articles using three-dimensional printing and for improving control of polymerization using a polymerization photoinhibitor having fast back reaction kinetics such as hexaarylbiimidazole compounds and bridged hexaarylbiimidazole compounds. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/389039 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Original (OR) Class C08F 4/04 (20130101) C08F 4/40 (20130101) C08F 222/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173125 | Turng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Lih-Sheng Turng (Madison, Wisconsin); Yiyang Xu (Madison, Wisconsin); Dongfang Wang (Madison, Wisconsin) |
| ABSTRACT | Methods of making polytetrafluoroethylene (PTFE)/polymer composites are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in artificial blood vessels, vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 16/744497 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/618 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/18 (20130101) A61L 27/26 (20130101) A61L 27/48 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/507 (20130101) A61L 2300/414 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/0012 (20190201) B29C 48/0018 (20190201) B29C 48/022 (20190201) B29C 48/023 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2027/18 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/005 (20130101) Original (OR) Class C08J 9/26 (20130101) C08J 9/283 (20130101) C08J 2201/046 (20130101) C08J 2201/0462 (20130101) C08J 2207/10 (20130101) C08J 2327/18 (20130101) C08J 2467/04 (20130101) C08J 2475/04 (20130101) Compositions of Macromolecular Compounds C08L 27/18 (20130101) C08L 2201/06 (20130101) C08L 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173263 | Fernandez-Alcon et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Geraldine A. Hamilton (Cambridge, Massachusetts); Christopher Hinojosa (Cambridge, Massachusetts); Karel Domansky (Charlestown, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Guy Thompson, II (Lexington, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Thomas Umundum (Salzburg, Austria); Alfred Paris (Salzburg, Austria); Georg Bauer (Salzburg, Austria) |
| ABSTRACT | An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together. |
| FILED | Friday, December 19, 2014 |
| APPL NO | 15/105388 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 61/18 (20130101) B01D 63/081 (20130101) B01D 67/0023 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/0645 (20130101) B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/26 (20130101) C12M 25/02 (20130101) C12M 35/04 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173286 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | UNIVERSITY OF MASSACHUSETTS (Westborough, Massachusetts) |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Neil Aronin (Newtonville, Massachusetts); Julia Alterman (Worcester, Massachusetts); Matthew Hassler (Worcester, Massachusetts) |
| ABSTRACT | Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 16/927543 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/343 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) C12N 2310/3521 (20130101) C12N 2310/3533 (20130101) C12N 2320/51 (20130101) C12N 2320/53 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173291 | Romesberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Floyd E. Romesberg (La Jolla, California); Michael P. Ledbetter (La Jolla, California); Rebekah J. Karadeema (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, cells, engineered microorganisms, and kits for increasing the production of polypeptides comprising one or more unnatural amino acids. Further provided are cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913226 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/405 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/67 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/3125 (20130101) C12N 2800/80 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173305 | Engelhardt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa); University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | John F. Engelhardt (Iowa City, Iowa); Ziying Yan (Iowa City, Iowa); Jianming Qiu (Overland Park, Kansas) |
| ABSTRACT | A recombinant mutant BoV genome is provided, as well as methods of using the vector, e.g., to prepare helper-free virus. |
| FILED | Friday, May 26, 2017 |
| APPL NO | 16/304064 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14321 (20130101) C12N 2750/14322 (20130101) C12N 2750/14343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173306 | Kaler |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Stephen G. Kaler (Bethesda, Maryland) |
| ABSTRACT | Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217961 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/34 (20130101) A61K 38/46 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2800/22 (20130101) Enzymes C12Y 306/03004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173313 | Andersen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Jimena Andersen (Palo Alto, California); Fikri Birey (Palo Alto, California); Sergiu P. Pasca (Palo Alto, California) |
| ABSTRACT | Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/671430 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) C12N 5/0012 (20130101) C12N 5/0062 (20130101) C12N 5/0619 (20130101) C12N 5/0622 (20130101) Original (OR) Class C12N 5/0623 (20130101) C12N 5/0696 (20130101) C12N 2501/01 (20130101) C12N 2501/11 (20130101) C12N 2501/13 (20130101) C12N 2501/15 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 2333/70571 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173314 | Siprashvili et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Zurab Siprashvili (San Mateo, California); Ngon T. Nguyen (Union City, California); M. Peter Marinkovich (Redwood City, California); Jean Tang (Stanford, California); Alfred T. Lane (Los Altos, California); Paul A. Khavari (Palo Alto, California) |
| ABSTRACT | Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet. |
| FILED | Tuesday, January 03, 2017 |
| APPL NO | 16/066253 |
| ART UNIT | 1638 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0629 (20130101) Original (OR) Class C12N 2510/00 (20130101) C12N 2760/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173315 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Frances Eun-Hyung Lee (Atlanta, Georgia); Ignacio Sanz (Atlanta, Georgia); Doan Nguyen (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises IL-6, fibronectin, and typically a saccharide. In certain embodiments, the disclosure contemplates cell culture compositions comprising IL-6 and fibronectin that are derived from proteins secreted from mesenchymal stromal/stem cells (MSCs). In certain embodiments, the disclosure contemplates enclosures comprising culture compositions disclosed herein that are in ambient air or optionally in an environment wherein oxygen is absent or at a low concentration. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406212 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2500/32 (20130101) C12N 2500/34 (20130101) C12N 2500/38 (20130101) C12N 2500/60 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/998 (20130101) C12N 2501/2305 (20130101) C12N 2501/2306 (20130101) C12N 2501/2321 (20130101) C12N 2502/1358 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173320 | Murphy et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOSTON MEDICAL CENTER CORPORATION (Boston, Massachusetts); TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | BOSTON MEDICAL CENTER CORPORATION (Boston, Massachusetts); TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | George J. Murphy (Boston, Massachusetts); David H. Sherr (West Roxbury, Massachusetts); Sarah S. Rozelle (Jamaica Plain, Massachusetts); Brenden W. Smith (Warwick, Rhode Island) |
| ABSTRACT | This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) modulator. In some embodiments the AhR modulator is an AhR antagonist. In some embodiments the AhR modulator is an AhR agonist. In some embodiments the methods comprise culturing MEP precursor cells in the presence of an AHR antagonist and then culturing MEP precursor cells in the presence of an AHR agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR modulator are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs, among other things. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407349 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/655 (20130101) A61K 35/18 (20130101) A61K 35/19 (20130101) A61K 45/06 (20130101) A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) C12N 5/0644 (20130101) C12N 5/0647 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2506/03 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/80 (20130101) G01N 33/86 (20130101) G01N 33/5044 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173326 | Schlesinger et al. |
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| FUNDED BY |
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| APPLICANT(S) | TEXAS BIOMEDICAL RESEARCH INSTITUTE (San Antonio, Texas) |
| ASSIGNEE(S) | TEXAS BIOMEDICAL RESEARCH INSTITUTE (San Antonio, Texas) |
| INVENTOR(S) | Larry S. Schlesinger (San Antonio, Texas); Susanta Pahari (San Antonio, Texas) |
| ABSTRACT | Provided here methods of generating human alveolar macrophage-like cells in-vitro from blood-derived monocytes by culturing them in a cell culture medium containing a mixture of a surfactant and two or more cytokines. This mixture can contain calfactant, granulocyte-macrophage colony-stimulating factor, transforming growth factor beta, and interleukin-10. |
| FILED | Wednesday, March 30, 2022 |
| APPL NO | 17/657344 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/22 (20130101) C12N 2501/231 (20130101) C12N 2506/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173334 | Ha et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Taekjip Ha (Baltimore, Maryland); Sinan Arslan (Urbana, Illinois) |
| ABSTRACT | Conformationally-constrained helicases having improved activity and strength are provided. Methods of making conformationally-constrained helicases having improved activity and strength are provided. Methods of using conformationally-constrained helicases having improved activity and strength are provided. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537419 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) Original (OR) Class C12N 9/90 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Enzymes C12Y 306/04012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173339 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Medford, Massachusetts); Alexander Sousa (Boston, Massachusetts) |
| ABSTRACT | Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with improved targeting range and enhanced on-target activity, and their use in genomic engineering, epigenomic engineering, base editing, genome targeting, genome editing, and in vitro diagnostics. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244738 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/52 (20130101) C12N 9/88 (20130101) Original (OR) Class C12N 15/62 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) C12Q 1/6813 (20130101) C12Q 2521/301 (20130101) Enzymes C12Y 401/99013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173355 | Vo-Dinh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Tuan Vo-Dinh (Chapel Hill, North Carolina); Hsin-Neng Wang (Durham, North Carolina); Andrew Fales (Durham, North Carolina) |
| ABSTRACT | Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 16/809674 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173361 | Ismagilov et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (, None) |
| INVENTOR(S) | Rustem F Ismagilov (Altadena, California); Jacob T Barlow (Pasadena, California); Said R Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems and related composition, to provide a rodent model having a target microbiome profile formed by a target presence, a target proportion and/or a target total load of a target prokaryote of a target taxon, based on absolute quantification of the target prokaryote. Further provided are rodents obtained by the methods herein described and related use in testing methods performed in connection with physiological or pathological conditions in an individual preferably a human individual. Also provided herein is a tailcup device and related use to prevent coprophagia in rodents. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148543 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/15 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173363 | Ismagilov et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Jacob T. Barlow (Pasadena, California); Said R. Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174104 | Berezin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mikhail Y. Berezin (St. Louis, Missouri); John Mark Meacham (St. Louis, Missouri); Michael Binkley (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Mikhail Y. Berezin (St. Louis, Missouri); John Mark Meacham (St. Louis, Missouri); Michael Binkley (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein is are methods for isolating mammalian cells under continuous flow conditions, enriching mammalian cells under continuous flow conditions, and enriching microorganisms under continuous flow conditions. The methods include providing and loading a plurality of mammalian cells or microorganisms into an acoustic separation device. The acoustic separation device includes: an inlet; an outlet; a channel coupled to the inlet and the outlet, wherein the channel defines a flow path between the inlet and the outlet; a standing acoustic wave generating device; and at least one pillar array comprising a plurality of pillars, wherein the at least one pillar array is situated within the flow path defined by the channel, wherein the at least one pillar array includes a first pillar array and a second pillar array, wherein the first pillar array is substantially parallel to the second pillar array, wherein the first pillar array and the second pillar array form an enrichment structure. The methods further include generating an augmented pressure field comprising locally augmenting, by the enrichment structure, a pressure field generated by the standing acoustic wave generating device. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222358 |
| ART UNIT | 1796 — Printing/Measuring and Testing |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/0829 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0436 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) Original (OR) Class G01N 33/54373 (20130101) G01N 2015/142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174115 | Vakoc et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Benjamin Vakoc (Arlington, Massachusetts); Norman Lippok (Cambridge, Massachusetts) |
| ABSTRACT | An apparatus, including: an electromagnetic radiation source producing radiation for illuminating a sample located at an optical path depth, the electromagnetic radiation source providing the radiation to the sample to facilitate determining the optical path depth within the sample: an interferometer including: a reference arm a first portion of the radiation is delivered to, a sample arm to which a second portion of the radiation is delivered, a first optical subsystem coupled to the sample arm to interrogate the sample with the radiation delivered to the sample arm and to collect backscattered radiation from the sample, and a second optical subsystem coupled to the reference arm and the first optical subsystem to generate interference fringes between the collected backscattered radiation and the radiation delivered to the reference arm; and a data collection and processing system configured to compute the optical path depth of the sample from the received interference fringes. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/755452 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) G01B 9/02007 (20130101) G01B 9/02008 (20130101) G01B 9/02091 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174140 | Ham et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donhee Ham (Cambridge, Massachusetts); Hongkun Park (Cambridge, Massachusetts); Keith Krenek (Cambridge, Massachusetts); Tianyang Ye (Cambridge, Massachusetts); Jeffrey T. Abbott (Cambridge, Massachusetts); Wenxuan Wu (Cambridge, Massachusetts) |
| ABSTRACT | Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 16/760723 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Original (OR) Class G01N 27/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174190 | Condeelis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | John S. Condeelis (Bronx, New York); Maja H. Oktay (Rye, New York); Joan Jones (Bronx, New York); David Entenberg (Granite Springs, New York) |
| ABSTRACT | A combination of markers (TMEM, MenaCalc, and MenalNV) for hematogenous metastatic cancer and their use for diagnosis, prognosis and predictive performance are disclosed. |
| FILED | Tuesday, December 18, 2018 |
| APPL NO | 16/955289 |
| ART UNIT | 1672 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57426 (20130101) Original (OR) Class G01N 2800/52 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174191 | Haab et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Van Andel Research Institute (Grand Rapids, Michigan); University of Pittsburgh-Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | VAN ANDEL RESEARCH INSTITUTE (Grand Rapids, Michigan); UNIVERSITY OF PITTSBURGH (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Brian B. Haab (Jenison, Michigan); Randall E. Brand (Sewickley, Pennsylvania) |
| ABSTRACT | A method of diagnosing pancreatic cancer in a patient by detecting a level of one or more glycoforms of a Lewis antigen and a level of the one or more glycoforms of MUC5AC. The patient diagnosed with pancreatic cancer then may be treated for this disease. Also, a method for detecting a level of a glycan in a sample which includes using a capture reagent to immobilize the glycan on a substrate; exposing the immobilized glycan to a detection reagent; detecting the level of the immobilized glycan; and combining the biological sample with one or more pre-capture enzymes and/or exposing the immobilized glycan to one or more pre-detection enzymes. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928293 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Enzymes C12Y 204/01065 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) Original (OR) Class G01N 2333/4725 (20130101) G01N 2333/91102 (20130101) G01N 2440/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174200 | M'Koma |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee) |
| ASSIGNEE(S) | Meharry Medical College (Nashville, Tennessee) |
| INVENTOR(S) | Amosy E. M'Koma (Nashville, Tennessee) |
| ABSTRACT | A targeted DEFA5 antibody is disclosed herein. The targeted DEFA5 antibody has a high degree of specificity with DEFA5 protein, particularly with peptide sequences of the P, B, and/or M binding sites of the DEFA5 protein. The targeted DEFA5 antibody may be incorporated into an assay for diagnosing and treating ulcerative colitis and Crohns disease in a subject suffering from inflammatory bowel disease. The assay may be provided in a kit. The targeted DEFA5 antibody may be used in a method for measuring the level of DEFA5 or DEFA5 expression in a sample collected from a subject, and determining, based on the level of DEFA5 or DEFA5 expression, whether the subject is suffering from ulcerative colitis or Crohns disease. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohns disease. |
| FILED | Wednesday, June 20, 2018 |
| APPL NO | 16/622259 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/4721 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174201 | Van Eyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California); THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California); The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jennifer Van Eyk (Los Angeles, California); Qin Fu (Beverly Hills, California); Vidya Venkatraman (Los Angeles, California); Zongming Fu (Laurel, Maryland); Josef Coresh (Chevy Chase, Maryland) |
| ABSTRACT | Described herein are methods for identification/discovery of protein biomarkers for chronic kidney disease (CKD) and diagnosing and/or prognosing and/or predicting progression of and/or treating chronic kidney disease (CKD). |
| FILED | Friday, October 12, 2018 |
| APPL NO | 16/754717 |
| ART UNIT | 1678 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/60 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174205 | Hou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Songwang Hou (Brookfield, Wisconsin); Ming Zhao (Oak Park, Illinois) |
| ABSTRACT | Provided herein are phosphatidylethanolamine (PE)-specific probes and methods of use thereof. In particular, the present invention provides conjugates of PE binding moieties with detectable markers, and methods of use thereof to detect and/or characterize PE within cells. |
| FILED | Friday, April 17, 2015 |
| APPL NO | 15/304671 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 49/0047 (20130101) A61K 49/0056 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/3348 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) C09K 2211/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/582 (20130101) G01N 2405/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174585 | Shoham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | Shy Shoham (Brooklyn, New York); Gilad Lerman (Jerusalem, Israel) |
| ABSTRACT | A holographic imaging system comprises an imaging light source defining an imaging light path, an active light source defining an active light path directed at a target, and a polarizer configured to modify the polarization of the active light path. The system further comprises a polarization beam splitter positioned in the active light path and the imaging light path, configured to separate the active light path and the imaging light path, and a photodetector positioned at a terminus of the active light path. The photodetector is configured to measure a reflection of the active light source. A method of holographic imaging is also described. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/351637 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/283 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 21/2073 (20130101) Holographic Processes or Apparatus G03H 1/0866 (20130101) Original (OR) Class G03H 2001/005 (20130101) G03H 2222/12 (20130101) G03H 2223/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175268 | Chaterji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Somali Chaterji (West Lafayette, Indiana); Saurabh Bagchi (West Lafayette, Indiana); Ashraf Mahgoub (West Lafayette, Indiana) |
| ABSTRACT | A system may forecast a workload for a cluster of nodes in a database management system. The system may generate a reconfiguration plan based on the forecasted workload. The system may obtain a heterogenous configuration set. The heterogenous configuration set may include respective configuration sets for the complete sets of nodes. The system may forecast, based on a first machine learning model, respective performance metrics for nodes in each of the complete sets. The system may forecast a cluster performance metric for the entire cluster of nodes based on a second machine learning model. The system may include, in response to satisfaction of an acceptance criterion, the heterogenous configuration set in the reconfiguration plan. The system may cause the cluster of nodes to be reconfigured based on the reconfiguration plan. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139958 |
| ART UNIT | 2199 — Interprocess Communication and Software Development |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3891 (20130101) G06F 9/44505 (20130101) G06F 9/45558 (20130101) Original (OR) Class G06F 16/182 (20190101) G06F 2009/4557 (20130101) G06F 2009/45583 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175594 | Mirramezani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Seyed Mehran Mirramezani (Albany, California); Shawn Shadden (Albany, California) |
| ABSTRACT | A computer-implemented method can include generating centerlines of a patient's cardiovascular network, determining geometric features of the cardiovascular network based on the centerlines and a three-dimensional (3D) computer model of the cardiovascular network, constructing a lumped parameter network (LPN) of resistors corresponding to the cardiovascular network, and solving a system of equations corresponding to flow and pressure for the LPN model. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 17/621645 |
| ART UNIT | 2616 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) A61B 2034/105 (20160201) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/60 (20130101) G06T 17/00 (20130101) Original (OR) Class G06T 2207/30048 (20130101) G06T 2207/30104 (20130101) G06T 2210/24 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175662 | Alizad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Azra Alizad (Rochester, Minnesota); Mostafa Fatemi (Rochester, Minnesota); Redouane Ternifi (Rochester, Minnesota); Yinong Wang (Rochester, Minnesota) |
| ABSTRACT | The present disclosure addresses a quantitative analysis of tumor vascularity patterns, with the goal of identifying biomarkers correlated with malignancy. Herein, we identify new types of quantitative ultrasound biomarkers of microvessel morphology that correlate with the state of the disease in question. We propose a novel method to automatically extract quantitative features related to the morphology and distribution of the vascular networks reconstructed from contrast-free ultrasound data. For instance, spatial vascularity pattern, bifurcation angle, Murray's deviation, fractal dimension and closet vessel distance were clearly depicted. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466773 |
| ART UNIT | 2671 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/73 (20170101) G06T 7/155 (20170101) G06T 2207/10132 (20130101) G06T 2207/20024 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) G06T 2207/30101 (20130101) G06T 2207/30172 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175734 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Daniel David Harrison (Delanson, New York); Xun Jia (Dallas, Texas); Klaus Mueller (New York, New York) |
| ABSTRACT | In some embodiments, a method of machine learning includes identifying, by an auto encoder network, a simulator feature based, at least in part, on a received first simulator data set and an emulator feature based, at least in part, on a received first emulator data set. The method further includes determining, by a synthesis control circuitry, a synthesized feature based, at least in part, on the simulator feature and based, at least in part, on the emulator feature; and generating, by the auto encoder network, an intermediate data set based, at least in part, on a second simulator data set and including the synthesized feature. Some embodiments of the method further include determining, by a generative artificial neural network, a synthesized data set based, at least in part, on the intermediate data set and based, at least in part, on an objective function. |
| FILED | Monday, February 11, 2019 |
| APPL NO | 16/969072 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0033 (20130101) Electric Digital Data Processing G06F 18/214 (20230101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/10 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 11/006 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176068 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); The Simons Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey); The Simons Foundation, Inc. (New York, New York) |
| INVENTOR(S) | Jian Zhou (Dallas, Texas); Chandra Theesfeld (Princeton, New Jersey); Olga G. Troyanskaya (Princeton, New Jersey) |
| ABSTRACT | Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels. |
| FILED | Tuesday, March 26, 2019 |
| APPL NO | 17/041836 |
| ART UNIT | 1672 — Amusement and Education Devices |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) Original (OR) Class G16B 20/50 (20190201) G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176196 | Wysocki et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Vicki Wysocki (Columbus, Ohio); Dalton Snyder (Columbus, Ohio); Benjamin Jones (Columbus, Ohio); Alyssa Stiving (Columbus, Ohio); Joshua Gilbert (Columbus, Ohio); Zachary Vanaernum (Columbus, Ohio); Sophie Harvey-Bernier (Columbus, Ohio) |
| ABSTRACT | Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel. |
| FILED | Sunday, December 15, 2019 |
| APPL NO | 17/431299 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/38 (20130101) H01J 49/061 (20130101) H01J 49/066 (20130101) H01J 49/0068 (20130101) Original (OR) Class H01J 49/426 (20130101) H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12177631 | Eddins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | David Eddins (Odessa, Florida); Joseph Walton (Tampa, Florida) |
| ABSTRACT | A device and method that supplements sensory input, thereby providing a supplemented sensory environment, to induce plasticity within the central nervous system that effectively overcomes sensory-neural processing deficits or strengthens specific sensory-neural abilities. In one implementation, ear-level hearing devices are used to deliver therapeutic sound with specific acoustic features that serve as archetypes of stimulus features for which sensory-neural processing is compromised by a sensory-neural deficit. |
| FILED | Monday, April 17, 2023 |
| APPL NO | 18/301536 |
| ART UNIT | 2694 — Selective Visual Display Systems |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 25/50 (20130101) Original (OR) Class H04R 25/70 (20130101) H04R 25/604 (20130101) H04R 2225/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 12171512 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) A61B 2034/302 (20160201) A61B 2034/2048 (20160201) A61B 2034/2051 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171818 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Rockville, Maryland); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195072 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171822 | Eappen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanaria Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | Sanaria Inc. (Rockville, Maryland) |
| INVENTOR(S) | Abraham G. Eappen (Ellicott City, Maryland); Stephen L. Hoffman (Gaithersburg, Maryland) |
| ABSTRACT | The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. |
| FILED | Thursday, December 07, 2023 |
| APPL NO | 18/532731 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/52 (20130101) A61K 2039/522 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/10 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171877 | Freeman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | William R. Freeman (Del Mar, California); Michael J. Sailor (La Jolla, California); Lingyun Cheng (San Diego, California) |
| ABSTRACT | This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics. |
| FILED | Thursday, February 07, 2019 |
| APPL NO | 16/270259 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 9/0051 (20130101) A61K 9/143 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 9/7007 (20130101) A61K 31/573 (20130101) A61K 31/7088 (20130101) A61K 38/482 (20130101) A61K 39/44 (20130101) A61K 39/395 (20130101) A61K 2039/54 (20130101) A61K 2039/505 (20130101) Enzymes C12Y 304/21073 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171885 | Lavik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
| INVENTOR(S) | Erin Lavik (Ellicott City, Maryland); Nuzhat Maisha (Halethorpe, Maryland) |
| ABSTRACT | One of the significant challenges to translation of intravenously administered nanomaterials has been complement-mediated infusion reactions which can be lethal. Slow infusions can reduce infusion reactions, but slow infusions are not always possible in applications like controlling bleeding following trauma. Nanocapsules based on polyurethane are introduced as candidates that do not substantially activate complement protein C5a and the PEGylation and functionalization of the nanocapsules with the GRGDS peptide to create a new class of hemostatic nanomaterials is disclosed. Advantageously, the nanocapsules substantially avoid complement-mediated infusion reactions, promote faster clotting than controls, maintain maximum clot firmness, and do not activate pro-inflammatory cytokines. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812746 |
| ART UNIT | 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/5146 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171888 | Bowlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | Virginia Commonwealth University (Richmond, Virginia); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| INVENTOR(S) | Gary Bowlin (Mechanicsville, Virginia); David Simpson (Mechanicsville, Virginia); James Bowman (Richmond, Virginia); Stephen Rothwell (Richmond, Virginia) |
| ABSTRACT | The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539273 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/28 (20130101) Original (OR) Class A61L 15/28 (20130101) A61L 15/32 (20130101) A61L 15/38 (20130101) A61L 15/44 (20130101) A61L 2300/252 (20130101) A61L 2300/254 (20130101) A61L 2300/418 (20130101) A61L 2400/04 (20130101) Compositions of Macromolecular Compounds C08L 5/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172014 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | The Feinstein Institutes For Medical Research (Manhasset, New York) |
| INVENTOR(S) | Chunyan Li (Manhasset, New York); Raj Kumar Narayan (Manhasset, New York) |
| ABSTRACT | A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal. The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/606364 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36025 (20130101) Original (OR) Class A61N 1/36031 (20170801) A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172038 | Westendorf et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (North Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) Original (OR) Class A61K 47/6841 (20170801) A61K 2039/54 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172052 | Eder |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INCLUDEHEALTH, INC. (Mason, Ohio) |
| ASSIGNEE(S) | INCLUDEHEALTH, Inc. (Mason, Ohio) |
| INVENTOR(S) | James Ryan Eder (Columbus, Ohio) |
| ABSTRACT | Systems and methods for providing a customized exercise protocol to a computing device of a user. As the user performs the exercise protocol, one or more cameras of the computing device can track the user's movements. The user's movement are assessed to determine if proper form and technique is being used. |
| FILED | Thursday, April 13, 2023 |
| APPL NO | 18/134281 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 24/0006 (20130101) A63B 24/0062 (20130101) Original (OR) Class A63B 24/0075 (20130101) A63B 2024/0068 (20130101) A63B 2024/0071 (20130101) A63B 2220/05 (20130101) A63B 2220/806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172166 | Adalsteinsson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Viktor A. Adalsteinsson (Wakefield, Massachusetts); Denis Loginov (Dorchester Center, Massachusetts); J. Christopher Love (Somerville, Massachusetts); Alan Stockdale (Providence, Rhode Island); Todd Gierahn (Brookline, Massachusetts) |
| ABSTRACT | Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990390 |
| ART UNIT | 1799 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50 (20130101) B01L 3/5085 (20130101) Original (OR) Class B01L 2300/12 (20130101) B01L 2300/0654 (20130101) B01L 2300/0829 (20130101) B01L 2300/0851 (20130101) B01L 2300/0896 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/01 (20240101) G01N 15/1425 (20130101) G01N 15/1433 (20240101) G01N 33/4833 (20130101) G01N 35/00029 (20130101) G01N 35/00871 (20130101) G01N 2015/1006 (20130101) G01N 2035/00148 (20130101) Optical Elements, Systems, or Apparatus G02B 21/006 (20130101) G02B 21/06 (20130101) G02B 21/008 (20130101) G02B 21/16 (20130101) G02B 21/26 (20130101) Image or Video Recognition or Understanding G06V 20/695 (20220101) G06V 20/698 (20220101) Pictorial Communication, e.g Television H04N 23/56 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172717 | Langston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Tye Langston (Lynn Haven, Florida); Dane Maglich (Panama City, Florida); David Swedberg (Panama City, Florida) |
| ABSTRACT | An apparatus for releasing a magnetic crawler from a ferromagnetic operating surface has a ramp fabricated from lightweight non-magnetic materials. The ramp includes a base portion, inclined upper portion for receiving a magnetic crawler, a front end and a rear end. Ferromagnetic members are positioned on the top surface of the upper portion and configured to be magnetically attached to the tracks or wheels of a magnetic crawler. Magnets are positioned on the bottom portion and configured to be magnetically attached to a ferromagnetic operating surface upon which the magnetic crawler operates. In some embodiments, the lightweight non-magnetic materials are highly buoyant. |
| FILED | Thursday, July 07, 2022 |
| APPL NO | 17/859925 |
| ART UNIT | 3653 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Motor Vehicles; Trailers B62D 55/265 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/0257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173018 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | VENATORX PHARMACEUTICALS, INC. (Malvern, Pennsylvania) |
| INVENTOR(S) | Christopher J. Burns (Malvern, Pennsylvania); Denis Daigle (Street, Maryland); Guo-Hua Chu (Exton, Pennsylvania); Jodie Hamrick (New Holland, Pennsylvania); Steven A. Boyd (Chester Springs, Pennsylvania); Allison L Zulli (Chesterbrook, Pennsylvania); Eugen F. Mesaros (Wallingford, Pennsylvania); Stephen M. Condon (Glenmoore, Pennsylvania); Robert E. Lee Trout (Collegeville, Pennsylvania); Cullen L. Myers (Exton, Pennsylvania); Zhenrong Xu (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173257 | Arkenljung |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BALDWIN JIMEK AB (Arlöv, Sweden) |
| ASSIGNEE(S) | BALDWIN JIMEK AB (Arlöv, Sweden) |
| INVENTOR(S) | Ulf Arkenljung (Malmö, Sweden) |
| ABSTRACT | A roll of cleaning fabric is used for cleaning printing cylinders of a printing system. The cleaning fabric (13) is impregnated with a cleaning composition containing an organic solvent and a cellulose solubilizer. The roll may be wound around a core (14) and inserted in a removable sealing bag (15) configured to seal around the roll (12) of cleaning fabric (13) in order to prevent the cleaning composition from evaporating before use. |
| FILED | Tuesday, August 13, 2019 |
| APPL NO | 17/264516 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Printing Machines or Presses B41F 35/00 (20130101) Indexing Scheme Relating to Printing, Lining Machines, Typewriters, and to Stamps B41P 2235/24 (20130101) B41P 2235/50 (20130101) Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 1/523 (20130101) C11D 3/30 (20130101) C11D 3/32 (20130101) C11D 3/2044 (20130101) C11D 3/2093 (20130101) C11D 17/049 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173263 | Fernandez-Alcon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jose Fernandez-Alcon (Cambridge, Massachusetts); Norman Wen (Newton, Massachusetts); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Geraldine A. Hamilton (Cambridge, Massachusetts); Christopher Hinojosa (Cambridge, Massachusetts); Karel Domansky (Charlestown, Massachusetts); Daniel Levner (Cambridge, Massachusetts); Guy Thompson, II (Lexington, Massachusetts); Kambez Hajipouran Benam (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Thomas Umundum (Salzburg, Austria); Alfred Paris (Salzburg, Austria); Georg Bauer (Salzburg, Austria) |
| ABSTRACT | An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together. |
| FILED | Friday, December 19, 2014 |
| APPL NO | 15/105388 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 61/18 (20130101) B01D 63/081 (20130101) B01D 67/0023 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/0645 (20130101) B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/26 (20130101) C12M 25/02 (20130101) C12M 35/04 (20130101) C12M 41/00 (20130101) C12M 41/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173281 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W. K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measuring target concentration, measuring effects of environmental conditions on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices include three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration in which they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices may carry DNA tags to enable separation of open and closed devices and barcoding for multiplexed detection. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542224 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/30 (20130101) C12Q 2525/197 (20130101) C12Q 2525/205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5308 (20130101) G01N 2333/705 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173355 | Vo-Dinh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Tuan Vo-Dinh (Chapel Hill, North Carolina); Hsin-Neng Wang (Durham, North Carolina); Andrew Fales (Durham, North Carolina) |
| ABSTRACT | Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 16/809674 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173361 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (, None) |
| INVENTOR(S) | Rustem F Ismagilov (Altadena, California); Jacob T Barlow (Pasadena, California); Said R Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems and related composition, to provide a rodent model having a target microbiome profile formed by a target presence, a target proportion and/or a target total load of a target prokaryote of a target taxon, based on absolute quantification of the target prokaryote. Further provided are rodents obtained by the methods herein described and related use in testing methods performed in connection with physiological or pathological conditions in an individual preferably a human individual. Also provided herein is a tailcup device and related use to prevent coprophagia in rodents. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148543 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/15 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173363 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Jacob T. Barlow (Pasadena, California); Said R. Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173670 | Garcia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northrop Grumman Systems Corporation (Plymouth, Minnesota) |
| ASSIGNEE(S) | Northrop Grumman Systems Corporation (Plymouth, Minnesota) |
| INVENTOR(S) | Benjamin W. C. Garcia (Tremonton, Utah); Brian Christensen (Willard, Utah); David R. Nelson (Logan, Utah) |
| ABSTRACT | A multi-component structure includes a first hybrid metal composite structure, a second hybrid metal composite structure, and a joint structure. The first and second hybrid metal composite structures include layers, each layer comprising a fiber composite material structure including a fiber material dispersed within a matrix material and at least one metal ply located between layers of the layers. The joint structure extends between and connects the first hybrid metal composite structure and the second hybrid metal composite structure. Additionally, the joint structure exerts a clamping force on the first and second hybrid metal composite structures and to reduce gaps between the layers, between the layers and the at least one metal ply, and between the joint structure and the first and second hybrid metal composite structures to less than half a thickness of the at least one metal ply. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197994 |
| ART UNIT | 1781 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/08 (20130101) B32B 9/047 (20130101) B32B 15/04 (20130101) B32B 18/00 (20130101) B32B 2250/42 (20130101) B32B 2262/105 (20130101) B32B 2262/106 (20130101) B32B 2307/54 (20130101) B32B 2307/306 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) Jet-propulsion Plants F02K 9/97 (20130101) F02K 9/343 (20130101) Original (OR) Class F02K 9/346 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/10 (20130101) F05D 2300/6032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173740 | Travis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Tewksbury, Massachusetts) |
| INVENTOR(S) | Robert D. Travis (Tucson, Arizona); Justin Powell (Tucson, Arizona) |
| ABSTRACT | A frangible detent pin comprising a base a pin head and an elastic member. The base is configured to be secured within a bore. The pin head and the base are interconnected through a frangible connection. The elastic member is configured to bias the pin head away from the base. The frangible detent pin has a rigid stage in which the pin head is rigidly positioned relative to the base and a spring-loaded stage in which the pin head is moveable relative to the base under a compression load between pin head and the base. The frangible detent pin is configured to transition from the rigid stage to the spring-loaded stage in response to the compression load exceeding a predetermined threshold sufficient to cause the frangible connection to fail. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/930233 |
| ART UNIT | 3656 — Material and Article Handling |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 19/002 (20130101) F16B 31/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173965 | Goodwin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Gabriel Goodwin (Washington, District of Columbia); Evan Hyde (Washington, District of Columbia); Jesse Maxwell (Washington, District of Columbia); Kwok Cheung (Washington, District of Columbia); Robert Baldauff (Washington, District of Columbia); Triem Hoang (Laurel, Maryland) |
| ABSTRACT | A hybrid capillary and mechanically pumped loop heat pipe (HLHP) includes a fluid loop having an evaporator thermally coupled to a heat load, a condenser thermally coupled to a heat sink, a reservoir, and one or more magnetically levitating pumps configured to pump fluid through the loop thereby improving heat transport capacity and system stability. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210407 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Non-positive-displacement Pumps F04D 29/058 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/025 (20130101) Original (OR) Class F28D 15/043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173988 | Rudolph et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Brandon W Rudolph (Bloomington, Indiana); Matthew A Thompson (Bloomington, Indiana); Daniel S Spoor (Bloomington, Indiana) |
| ABSTRACT | Disclosed is an extended range multi-caliber in-bore laser boresight system for sighting in a firearm. The device includes one or more hollow cartridge cases that resemble a standard firearm case lacking a bullet, a laser module, and an external electronic package. The laser module fits within the hollow cartridge case and is positioned within a firearm chamber. The laser exits the hollow cartridge through the firearm barrel to aid with zeroing a firearm sighting system. The laser diode is powerful enough to be visible at extended ranges in bright sunlight. The inventive boresight system can be used for zeroing any desired caliber, such as from 5.56 NATO to .50 BMG at extended range. |
| FILED | Wednesday, April 05, 2023 |
| APPL NO | 18/131225 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Weapon Sights; Aiming F41G 1/545 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 5/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173997 | Speirs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (, None) |
| INVENTOR(S) | Nathan B Speirs (Provo, Utah); David E Yamartino (Riverside, Rhode Island); Aren M Hellum (Wakefield, Rhode Island); Jesse L Belden (Dighton, Massachusetts) |
| ABSTRACT | A variable diameter conical nose is provided. The conical nose includes a cone formed from a circular sheet of ductile material having a sector removed. The formed cone has a first overlapping portion and a second overlapping portion overlying the first overlapping portion. The first overlapping portion is fixed and the second overlapping portion is free to move. The conical nose includes an actuator capable of varying the diameter of the cone by moving the second overlapping portion relative to the first overlapping portion. |
| FILED | Monday, August 14, 2023 |
| APPL NO | 18/233427 |
| ART UNIT | 3618 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 19/005 (20130101) F42B 19/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173998 | Sanford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (Indian Head, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Matt Sanford (Bel Alton, Maryland); Zaeemuddin Husain (LaPlata, Maryland) |
| ABSTRACT | An active hazard mitigation device includes a reservoir containing thermal wax and a slider translatable from a safe position to an armed position. A conduit for flow of the thermal wax in a melted state extends from the thermal wax reservoir to a rear of the safe position of the slider. A BKNO3 pellet is disposed in a forward end of the slider. A lithium intermetallic thermal sensor is disposed adjacent the BKNO3 pellet when the slider is in an armed position. When the thermal wax expands, the slider moves from the safe position to the armed position under the lithium intermetallic thermal sensor. When the lithium intermetallic thermal sensor activates, heat from the lithium intermetallic thermal sensor ignites the BKNO3 pellet in the slider and thereby produces gas and heat that ignites energetic material disposed proximate to the BKNO3 pellet. |
| FILED | Monday, October 30, 2023 |
| APPL NO | 18/445577 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 39/14 (20130101) F42B 39/20 (20130101) Original (OR) Class Ammunition Fuzes; Arming or Safety Means Therefor F42C 15/36 (20130101) F42C 15/184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174004 | Thompson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Clayton Andrew Thompson (Bedford, Indiana) |
| ABSTRACT | Provided is a multi-configuration transportable demolition pouch that includes a cruciform shaped section of fabric with a central explosive containing area and four trimmable flaps, a fastener on each of the flaps, a strap accepting slit, a first and a second strap, a fabric lid and priming hole, and one or more energetic device that can be selected based on desired blast footprint. The pouch can be trimmed when using smaller quantities of explosives to reduce its footprint and facilitate ease of carrying and emplacement. The device has attachment features to aid in transport and to provide proper spacing and attachment points for demolitions and breeching techniques involving multiple charges. The pouch provides components to allow for blast footprint alteration and for water tamping to reduce blast effects to nearby personnel, as well as to increase the efficiency of the explosive charge. |
| FILED | Thursday, June 01, 2023 |
| APPL NO | 18/204610 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Blasting F42D 3/02 (20130101) F42D 5/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174018 | Hamerly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); NTT Research, Incorporated (Sunnyvale, California) |
| INVENTOR(S) | Ryan Hamerly (Cambridge, Massachusetts); Saumil Bandyopadhyay (Cambridge, Massachusetts); Dirk Robert Englund (Brookline, Massachusetts) |
| ABSTRACT | Component errors prevent linear photonic circuits from being scaled to large sizes. These errors can be compensated by programming the components in an order corresponding to nulling operations on a target matrix X through Givens rotations X→T†X, X→XT†. Nulling is implemented on hardware through measurements with feedback, in a way that builds up the target matrix even in the presence of hardware errors. This programming works with unknown errors and without internal sources or detectors in the circuit. Modifying the photonic circuit architecture can reduce the effect of errors still further, in some cases even rendering the hardware asymptotically perfect in the large-size limit. These modifications include adding a third directional coupler or crossing after each Mach-Zehnder interferometer in the circuit and a photonic implementation of the generalized FFT fractal. The configured photonic circuit can be used for machine learning, quantum photonics, prototyping, optical switching/multicast networks, microwave photonics, or signal processing. |
| FILED | Friday, April 01, 2022 |
| APPL NO | 17/711640 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0207 (20130101) Original (OR) Class G01B 9/02027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174020 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| INVENTOR(S) | Wonjae Lee (Princeton, New Jersey); Michael Romalis (Princeton, New Jersey); Vito Giovanni Lucivero (Barcelona, Spain); Mark Limes (Princeton, New Jersey); Elizabeth Foley (Plainsboro, New Jersey); Tom Kornack (Plainsboro, New Jersey) |
| ABSTRACT | According to various embodiments, a method for reducing heading error in a magnetometer that uses Rb-87 atoms is disclosed. The method includes varying a direction and magnitude of a magnetic field at different spin polarization regimes. According to various embodiments, a magnetometer adapted for reduced heading error is disclosed. The magnetometer includes a multipass cell containing Rb-87 vapor, a pump laser operated in a pulse mode that is synchronous with a Larmor frequency, and two orthogonal probe lasers configured to rotate to vary a direction and magnitude of a magnetic field at different spin polarization regimes. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333474 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 17/28 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174074 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Min Zhou (Atlanta, Georgia); Amirreza Keyhani (Atlanta, Georgia); Rong Yang (Atlanta, Georgia) |
| ABSTRACT | An embodiment provides a system for measuring temperature and deformation fields of at least a portion of a sample, comprising a visible light camera, an infrared camera, and a beam splitter. The visible light camera is at a first location with respect to the sample and can take a visible light image of at least a portion of the sample at a first time. The infrared camera is at a second location with respect to the sample and can take an infrared image of the at least a portion of the sample at the first time. The beam splitter can receive a beam of light, comprising infrared and visible light, traveling in a direction normal to the at least a portion of the sample and direct the infrared light to the infrared camera and the visible light to the visible light camera. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 17/424845 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/04 (20130101) G01J 5/80 (20220101) G01J 5/485 (20220101) G01J 5/0859 (20130101) Original (OR) Class G01J 5/0875 (20130101) G01J 2005/0077 (20130101) Optical Elements, Systems, or Apparatus G02B 27/141 (20130101) Image Data Processing or Generation, in General G06T 7/80 (20170101) G06T 2207/10048 (20130101) Pictorial Communication, e.g Television H04N 5/04 (20130101) H04N 17/002 (20130101) H04N 23/56 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174116 | Mohammed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Mohammed Tharwat Hassan Mohammed (Tucson, Arizona); Dandan Hui (Tucson, Arizona); Husain Alqattan (Tucson, Arizona) |
| ABSTRACT | Methodology for optical switching and/or coding of information with attosecond time resolution and, in particular, binary encoding of data based on modulation of reflectivity or transmissivity of a target non-electrically-conducting material system in a strong light field. |
| FILED | Wednesday, April 27, 2022 |
| APPL NO | 18/557478 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/55 (20130101) G01N 21/59 (20130101) Original (OR) Class G01N 2021/1725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174140 | Ham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Donhee Ham (Cambridge, Massachusetts); Hongkun Park (Cambridge, Massachusetts); Keith Krenek (Cambridge, Massachusetts); Tianyang Ye (Cambridge, Massachusetts); Jeffrey T. Abbott (Cambridge, Massachusetts); Wenxuan Wu (Cambridge, Massachusetts) |
| ABSTRACT | Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells. |
| FILED | Tuesday, October 30, 2018 |
| APPL NO | 16/760723 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 41/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/327 (20130101) Original (OR) Class G01N 27/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174181 | Biris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Alexandru S. Biris (Little Rock, Arkansas); Andrew G. Kumpuris (Little Rock, Arkansas); Zeid Nima (Little Rock, Arkansas) |
| ABSTRACT | A method of making a nanocomposite includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer; coating a pegylated layer on the assembled Raman reporter molecule layer; and conjugating the coated pegylated layer with an active layer, the active layer comprising at least one of a targeting molecule configured to bind to the target of interest and a functional molecule configured to interact with the target of interest. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400365 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/54346 (20130101) Original (OR) Class G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174213 | Stoll et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Kyle D. Stoll (Montgomery, Indiana); Eric Scheid (Bloomington, Indiana) |
| ABSTRACT | Provided is a new and improved method for examining the penetration of fragments in ballistic gelatin through the use of state-of-the art computed tomography (CT) equipment and analytical software. The inventive method can be used for fragment penetration testing as a key performance parameter (KPP). Ballistic gel containing multiple fragments are obtained, placed in a container, positioned in a CT chamber, and scanned. The scan is imported into a Volume graphics software program. A surface determination is made, which is used by one or more algorithms to isolate potential fragmentation within the gel block. The number of fragments, depth of penetration, and fragment mass are then calculated. |
| FILED | Thursday, March 31, 2022 |
| APPL NO | 17/709952 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 35/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 9/36 (20130101) Original (OR) Class G01N 23/18 (20130101) G01N 23/046 (20130101) G01N 2223/401 (20130101) Image Data Processing or Generation, in General G06T 5/70 (20240101) G06T 7/0002 (20130101) G06T 7/62 (20170101) G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174225 | Wolfowicz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Gary Wolfowicz (Paris, France); Samuel James Whiteley (Los Gatos, California); David Daniel Awschalom (Chicago, Illinois) |
| ABSTRACT | Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158895 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 15/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174237 | Krishnamoorthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas); The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Harish Krishnamoorthy (Missouri City, Texas); Joshua Hawke (Bloomington, Indiana) |
| ABSTRACT | A system for monitoring a circuit, comprising a device under test, such as a power field effect transistor or capacitor, coupled to a power source and a signal source and configured to generate a power output using the signal source, a current output, a voltage output and an end of life detector coupled to the current output and the voltage output and configured to generate a first impedance as a function of the current output and the voltage output, to compare the first impedance to a second impedance and to generate an indicator if the first impedance exceeds the second impedance. |
| FILED | Friday, October 07, 2022 |
| APPL NO | 17/961854 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/64 (20200101) G01R 31/2621 (20130101) Original (OR) Class G01R 31/2834 (20130101) G01R 31/2837 (20130101) G01R 31/2844 (20130101) G01R 31/2846 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174426 | Withers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Nathan Jack Withers (Albuquerque, New Mexico); Marek Osinski (Albuquerque, New Mexico) |
| ABSTRACT | A semiconductor photodetector comprising a closed loop configured to receive light from an external source adapted to trap light within said closed loop until absorption by the semiconductor. |
| FILED | Thursday, September 21, 2023 |
| APPL NO | 18/472183 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/125 (20130101) G02B 6/243 (20130101) Original (OR) Class G02B 6/266 (20130101) G02B 6/1225 (20130101) G02B 6/12007 (20130101) G02B 6/29338 (20130101) G02B 2006/1213 (20130101) G02B 2006/12097 (20130101) G02B 2006/12104 (20130101) G02B 2006/12119 (20130101) G02B 2006/12126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174436 | Morgan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Wesley Morgan (Lake Oswego, Oregon); Srikant Nekkanty (Chandler, Arizona); Todd R. Coons (Gilbert, Arizona); Gregorio R. Murtagian (Phoenix, Arizona); Xiaoqian Li (Chandler, Arizona); Nitin Deshpande (Chandler, Arizona); Divya Pratap (Hillsboro, Oregon) |
| ABSTRACT | Embodiments disclosed herein include photonics packages and systems. In an embodiment, a photonics package comprises a package substrate, where the package substrate comprises a cutout along an edge of the package substrate. In an embodiment, a photonics die is coupled to the package substrate, and the photonics die is positioned adjacent to the cutout. In an embodiment, the photonics package further comprises a receptacle for receiving a pluggable optical connector. In an embodiment, the receptacle is over the cutout. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214035 |
| ART UNIT | 2635 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4204 (20130101) Original (OR) Class G02B 6/4261 (20130101) G02B 6/4278 (20130101) G02B 6/4292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174544 | Eden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (, None) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | J. Gary Eden (Champaign, Illinois); Andrey Mironov (Urbana, Illinois); Dane J. Sievers (Fisher, Illinois) |
| ABSTRACT | A method for photoresist-free photolithography to pattern a surface of conductor or semiconductor substrate and deposit a material includes surface cleaning and irradiating a surface through a mask with VUV photons from a lamp. Photons are generated with a VUV lamp having a wavelength of 160 nm-200 nm and with an intensity sufficient to alter the surface. The photons are directed through a mask pattern to alter the surface chemistry or structure in those areas of the substrate defined by the mask. Material is selectively deposited onto the surface, in those portions of the surface that are exposed to the VUV photons, or unexposed to the VUV photons, depending on the substrate surface. A method uses a seed film and then electroplates metal onto the seed film in the mask pattern. A method provides for electroless deposition of metal and another for altering surface chemistry in the mask pattern. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/612830 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/1608 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 7/12 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/164 (20130101) G03F 7/70016 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/288 (20130101) H01L 21/2885 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174628 | Bronikowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Scott Alan Bronikowski (South Milwaukee, Wisconsin); Daniel Paul Barrett (South Bend, Indiana); Haonan Yu (Sunnyvale, California); Jeffrey Mark Siskind (West Lafayette, Indiana) |
| ABSTRACT | A system for directing the motion of a vehicle, comprising receiving commands in natural language using a processor, the commands specifying a relative path to be taken by the vehicle with respect to other objects in the environment; and determining an absolute path for the vehicle to follow based on the relative path using the processor, the absolute path comprising a series of coordinates in the environment; and directing the vehicle along the absolute path. Also provided is a system for training a lexicon of a natural language processing system, comprising receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of the absolute paths using a processor, and determining parameters of the lexicon based on the data set. |
| FILED | Friday, August 25, 2017 |
| APPL NO | 16/328202 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/10 (20130101) B60W 50/08 (20130101) B60W 50/10 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/10 (20130101) G05D 1/0033 (20130101) Original (OR) Class G05D 1/0088 (20130101) G05D 1/0221 (20130101) G05D 1/0231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174755 | Botman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arm Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | Arm Limited (Cambridge, United Kingdom) |
| INVENTOR(S) | François Christopher Jacques Botman (Cambridge, United Kingdom); Thomas Christopher Grocutt (Cambridge, United Kingdom); Bradley John Smith (Cambridge, United Kingdom) |
| ABSTRACT | An apparatus and method for constraining access to memory using capabilities. Processing circuitry performs operations during which access requests to memory are generated, with memory addresses for the access requests being generated using capabilities that identify constraining information. Capability checking circuitry performs a capability check operation to determine whether a given access request whose memory address is generated using a given capability is permitted based on the constraining information. Memory access checking circuitry then further constrains access to the memory by the given access request in dependence on a level of trust. The given capability has a capability level of trust associated therewith, and the level of trust associated with the given access request is dependent on both the current mode level of trust associated with the current mode of operation of the processing circuitry, and the capability level of trust of the given capability. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 18/247400 |
| ART UNIT | 2138 — Memory Access and Control |
| CURRENT CPC | Electric Digital Data Processing G06F 12/1491 (20130101) Original (OR) Class G06F 21/566 (20130101) G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174759 | Hornung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | Micron Technology, Inc. (Boise, Idaho) |
| INVENTOR(S) | Bryan Hornung (Plano, Texas); Tony M. Brewer (Plano, Texas); Douglas Vanesko (Dallas, Texas); Patrick Estep (Rowlett, Texas) |
| ABSTRACT | Linear interpolation is performed within a memory system. The memory system receives a floating-point point index into an integer-indexed memory array. The memory system accesses the two values of the two adjacent integer indices, performs the linear interpolation, and provides the resulting interpolated value. In many system architectures, the critical limitation on system performance is the data transfer rate between memory and processing elements. Accordingly, reducing the amount of data transferred improves overall system performance and reduces power consumption. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240492 |
| ART UNIT | 3667 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/41 (20130101) G01S 13/933 (20200101) G01S 13/9021 (20190501) Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/3887 (20130101) G06F 13/1668 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175103 | Powers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Architecture Technology Corporation (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Architecture Technology Corporation (Minneapolis, Minnesota) |
| INVENTOR(S) | Judson Powers (Ithaca, New York); Colleen Kimball (Ithaca, New York); Matthew A. Stillerman (Ithaca, New York) |
| ABSTRACT | Systems and methods for analyzing memory architectures and for mapping data structures in software programs to appropriate memory to take advantage of the different memory architectures. A computer architecture having a processor connected to one or more first memories and one or more second memories is defined, wherein the first memories and the second memories are characterized by different performance profiles. An executable of a software program is instrumented to capture, during runtime, patterns of access to selected data structures of the executable. Based on an analysis of the patterns of access, allocation of the selected data structures between the first and second memories is determined. |
| FILED | Monday, September 10, 2018 |
| APPL NO | 16/126728 |
| ART UNIT | 2132 — Memory Access and Control |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0631 (20130101) Original (OR) Class G06F 3/0683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175335 | Bandyopadhyay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Saumil Bandyopadhyay (Cambridge, Massachusetts); Ryan Hamerly (Cambridge, Massachusetts); Dirk Robert Englund (Brookline, Massachusetts) |
| ABSTRACT | Programmable photonic circuits of reconfigurable interferometers can be used to implement arbitrary operations on optical modes, providing a flexible platform for accelerating tasks in quantum simulation, signal processing, and artificial intelligence. A major obstacle to scaling up these systems is static fabrication error, where small component errors within each device accrue to produce significant errors within the circuit computation. Mitigating errors usually involves numerical optimization dependent on real-time feedback from the circuit, which can greatly limit the scalability of the hardware. Here, we present a resource-efficient, deterministic approach to correcting circuit errors by locally correcting hardware errors within individual optical gates. We apply our approach to simulations of large-scale optical neural networks and infinite impulse response filters implemented in programmable photonics, finding that they remain resilient to component error well beyond modern day process tolerances. Our error correction process can be used to scale up programmable photonics within current fabrication processes. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556033 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/212 (20210101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) G06N 10/70 (20220101) Original (OR) Class Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175421 | Ahern et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Austin Ahern (Albuquerque, New Mexico); Eric Dittman (Colorado Springs, Colorado); Michael Anderson (Colorado Springs, Colorado); Acierto Cabigas, III (Newport News, Virginia); Ashton Barnes (Colorado Springs, Colorado); Elliott Weiler (Newport News, Virginia); David Rochester (Yokota Air Base, Japan) |
| ABSTRACT | A system for asset inventory and resupply for supplying individuals in remote locations is disclosed. The individuals may be people and/or machines. The system and method involve providing multiple individuals in the field with sensors that automatically collect data on the expenditure of their supplies. In some cases, wearable sensors are provided to people in the field. The data is sent to a central depository which tracks their inventory of supplies and anticipates needed supplies, compiles and packages additional supplies so that the additional supplies can be delivered to the individuals in the field. A precision supply delivery system is provided for delivering the supplies. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/483862 |
| ART UNIT | 3627 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/02 (20130101) F42B 12/58 (20130101) F42B 15/08 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/087 (20130101) Original (OR) Class Information and Communication Technology Specially Adapted for the Internet of Things [IOT] G16Y 20/30 (20200101) G16Y 40/35 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175688 | Menozzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| INVENTOR(S) | Alberico Menozzi (Raleigh, North Carolina); Chris F. Argenta (Cary, North Carolina); James B. Cook (Apex, North Carolina) |
| ABSTRACT | The described technology regards an augmented reality system and method for estimating a position of a location of interest relative to the position and orientation of a display, including receiving and selectively filtering a plurality of measurement vectors from a rate-gyroscope. Systems of the described technology include including a plurality of sensors, a processing module or other computation means, and a database. Methods of the described technology use data from the sensor package useful to accurately render graphical user interface information on a display. |
| FILED | Wednesday, August 16, 2023 |
| APPL NO | 18/234769 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/1654 (20200801) G01C 21/1656 (20200801) Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) G02B 27/0093 (20130101) G02B 2027/0138 (20130101) G02B 2027/0141 (20130101) G02B 2027/0181 (20130101) Electric Digital Data Processing G06F 1/163 (20130101) G06F 3/01 (20130101) G06F 3/011 (20130101) G06F 3/04817 (20130101) G06F 11/00 (20130101) Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/33 (20170101) Original (OR) Class G06T 11/00 (20130101) G06T 19/006 (20130101) G06T 2200/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176173 | Fairchild et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Steven Fairchild (Beavercreek, Ohio); Dmitri Tsentalovich (Austin, Texas); Nathaniel Lockwood (Alexandria, Virginia) |
| ABSTRACT | A field emission (FE) cathode for a vacuum electronic device (VED) includes a metallic substrate configured to be connected to one of an electrical power supply and an electrical ground, and at least one continuous carbon nanotube (CNT) fiber in tension around at least a portion of the metallic substrate. The substrate can be a cylinder, hoop, plate, stub etc. The at least one continuous CNT fiber can include a filament, yarn, braided yarn, film, fabric, or combination thereof. The at least one continuous CNT fiber is secured to the electrically conductive substrate by vacuum brazing or any other suitable means. Also, a continuous CNT fabric can be secured in either tension or compression to maintain a uniform height of the continuous CNT fabric. |
| FILED | Thursday, February 08, 2024 |
| APPL NO | 18/436353 |
| ART UNIT | 2875 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/304 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176428 | Goodman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Kevin D. Goodman (Ellettsville, Indiana) |
| ABSTRACT | Provided is a cadmium selenide-indium arsenide heterojunction bipolar transistor. The device includes a first layer comprising a collector of the transistor made of n-type cadmium selenide, a base layer containing indium arsenide, and an emitter layer that reverts to cadmium selenide. The inventive device includes a large neutron cross section via the cadmium selenide layer. The cadmium selenide layer holds a high reaction rate with neutrons thus altering the electrical signal of the HBT in a neutron environment. The inventive HBT also yields higher gains than current homojunction bipolar transistors, such as those utilizing pure indium arsenide or silicon. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/684712 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/36 (20130101) H01L 29/45 (20130101) H01L 29/267 (20130101) H01L 29/7371 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176454 | Palacios et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Tomas Palacios (Belmont, Massachusetts); Jung-Han Hsia (Cambridge, Massachusetts) |
| ABSTRACT | Described herein is a semiconductor structure, comprising: a drain region; a drift region comprised of a wide band gap material disposed over the drain region; and a channel structure disposed over the drift region. In some embodiments, the channel structure comprises: an optically active material disposed over the drift region, wherein the optically active material generates charge carriers in response to an optical signal; and a source region disposed over the optically active material, wherein in an off state charge carriers in the optically active material are depleted to turn off the semiconductor structure, and in an on state charge carriers in the optically active material conduct a current in the semiconductor structure when an electric field is applied across the source region and drain region, causing the current to substantially flow directly between the source region and the drain region. |
| FILED | Friday, April 05, 2024 |
| APPL NO | 18/627725 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/032 (20130101) H01L 31/0312 (20130101) H01L 31/1136 (20130101) Original (OR) Class H01L 31/03044 (20130101) H01L 31/03046 (20130101) H01L 31/035281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176474 | Toda |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Asako Toda (Santa Clara, California) |
| ABSTRACT | Embodiments disclosed herein include optical packages. In an embodiment, an optical package comprises a package substrate and a compute die on the package substrate. In an embodiment, an optics die is on the package substrate, and an integrated heat spreader (IHS) is over the compute die and the optics die. In an embodiment, channels are disposed on a surface of the IHS facing the package substrate. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125505 |
| ART UNIT | 2897 — Semiconductors/Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4251 (20130101) G02B 6/4269 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/075 (20130101) H01L 33/58 (20130101) H01L 33/642 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176930 | Steenson, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | James H. Steenson, Jr. (Hudson, New Hampshire); Joseph P. Cullen (Chelmsford, Massachusetts) |
| ABSTRACT | Techniques to dynamically adjust the corner frequency of a high-pass filter in response to a time-domain amplitude value of an output signal, thereby preserving accuracy while promptly recovering the signal's baseline value. A system can be configured to filter frequency-domain values of an input signal based on a filtering characteristic. The filtering characteristic can be set dynamically in response to a time-domain value of an amplitude of an output signal. The filtering characteristic can comprise a corner frequency, and the system can include a high-pass filter configured to filter out frequency components at frequencies lower than the corner frequency. The system is configured to dynamically change the corner frequency from a first value to a second value, in response to the time-domain value of the amplitude crossing a threshold value. The system may dynamically change the corner frequency within a time interval after the crossing. |
| FILED | Tuesday, July 26, 2022 |
| APPL NO | 17/815164 |
| ART UNIT | 2631 — Digital Communications |
| CURRENT CPC | Transmission H04B 1/001 (20130101) Original (OR) Class H04B 1/0014 (20130101) H04B 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176949 | Adleman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | James Richard Adleman (San Diego, California); Sanja Zlatanovic (San Diego, California); David Chao (San Diego, California) |
| ABSTRACT | A radio frequency (RF) transceiver comprising: a transmitter configured to produce a plurality of optical carriers; a multi-wavelength electro-optic modulator configured to receive the plurality of optical carriers from the transmitter, wherein the electro-optic modulator is configured to modulate each optical carrier using a same input RF signal, but with a different efficiency for each optical carrier so as to generate an arbitrary number of RF links with various efficiencies using a single modulation electrode; and a receiver designed to produce a synthesized transfer function based on a truncated Fourier Series and configured to use the synthesized transfer function to adjust intermodulation distortion response to optimize dynamic range for the transceiver's operating resolution bandwidth and noise characteristics. |
| FILED | Friday, September 30, 2022 |
| APPL NO | 17/957068 |
| ART UNIT | 2634 — Digital Communications |
| CURRENT CPC | Transmission H04B 10/40 (20130101) H04B 10/54 (20130101) H04B 10/2543 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176973 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | Lehigh University (, None) |
| INVENTOR(S) | Yahong Rosa Zheng (Bethlehem, Pennsylvania); Xiyuan Zhu (Bethlehem, Pennsylvania) |
| ABSTRACT | An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/143839 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12177968 | Rogers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | John E. Rogers (Owens Cross Roads, Alabama); John D. Williams (Decatur, Alabama) |
| ABSTRACT | A flexible electronics assembly including a substrate including one or more dielectrics. A cavity is formed within the substrate. A first ground plane is secured to the substrate. One or more stress channels are formed through one or more portions of the substrate and the first ground plane. An electronics component is disposed within the cavity. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 16/839565 |
| ART UNIT | 2847 — Electrical Circuits and Systems |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/05 (20130101) H05K 1/115 (20130101) H05K 1/189 (20130101) H05K 1/0271 (20130101) H05K 1/0281 (20130101) Original (OR) Class H05K 1/0393 (20130101) H05K 2201/05 (20130101) H05K 2201/093 (20130101) H05K 2201/0183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178140 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | Northeastern University (Boston, Massachusetts) |
| INVENTOR(S) | Nian-Xiang Sun (Winchester, Massachusetts); Nirjhar Bhattacharjee (Cambridge, Massachusetts) |
| ABSTRACT | A thin film heterostructure of a topological insulator (TI) with a normal metal (NM) is used as a highly energy efficient and low power dissipation spin Hall Material (SHM). The TI material is sputter deposited onto a substrate and cooled in high vacuum, and an NM material is sputter deposited onto the TI film. The structure and method is compatible with complementary metal oxide (CMOS) processes, and with growth of large-area TI films for wafer-level device fabrication. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/457348 |
| ART UNIT | 1785 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) Electric solid-state devices not otherwise provided for H10N 50/80 (20230201) H10N 50/85 (20230201) H10N 52/01 (20230201) H10N 52/80 (20230201) H10N 52/101 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 12171512 | Mondry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) A61B 2034/302 (20160201) A61B 2034/2048 (20160201) A61B 2034/2051 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171529 | Ertin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Emre Ertin (Columbus, Ohio); William T. Abraham (Columbus, Ohio) |
| ABSTRACT | Various examples related to mobile bodily monitoring using ultra-wideband radar are provided. In one example, a method for determining a bodily characteristic includes collecting sets of reflected backscatter data for a sequence of ultra-wideband (UWB) pulses transmitted via an UWB sensor, and a corresponding calibration measurement from a calibration channel; determining reflection coefficients for each tissue interface based on the sets of reflected backscatter data; and determining a fluid level content of the lung tissue based upon the reflection coefficients. The reflection coefficients can be determined from reflection profiles based upon the reflected backscatter data for that sequence of UWB pulses and the corresponding calibration measurement. The UWB sensor can include an array of transmit (TX) and receive (RX) antenna pairs positioned on a body of a user. The reflection profile can be associated with a model of tissue layers in the body between the UWB sensor and lung tissue. |
| FILED | Wednesday, July 17, 2019 |
| APPL NO | 17/260827 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/07 (20130101) A61B 5/0205 (20130101) Original (OR) Class A61B 5/0507 (20130101) A61B 5/0537 (20130101) A61B 5/6833 (20130101) A61B 2560/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171809 | Kiick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Delaware (Newark, Delaware) |
| ASSIGNEE(S) | UNIVERSITY OF DELAWARE (Newark, Delaware) |
| INVENTOR(S) | Kristi Kiick (Rising Sun, Maryland); Millicent Sullivan (Wilmington, Delaware); Morgan Urello (Gaithersburg, Maryland) |
| ABSTRACT | The present invention provides a composition for delivering a polynucleotide into cells via a polyplex. The polyplex comprises the polynucleotide and a polymer. The composition comprises the polyplex, a collagen-mimetic peptide (CMP) and collagen fragments. The CMP is bound to the polyplex and the collagen fragments. Also provided are the uses of the composition in methods of delivering a polynucleotide into cells as well as methods of improving wound healing in a subject, enhancing cell proliferation in a subject, enhancing production of extracellular matrix by cells in a subject and/or enhancing cell migration by cells in a subject. |
| FILED | Tuesday, July 18, 2017 |
| APPL NO | 16/316378 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) A61K 38/20 (20130101) A61K 38/21 (20130101) A61K 38/39 (20130101) Original (OR) Class A61K 38/191 (20130101) A61K 38/4886 (20130101) A61K 47/6455 (20170801) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0008 (20130101) A61K 48/0025 (20130101) A61K 48/0041 (20130101) A61K 48/0075 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6491 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 304/24007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171877 | Freeman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | William R. Freeman (Del Mar, California); Michael J. Sailor (La Jolla, California); Lingyun Cheng (San Diego, California) |
| ABSTRACT | This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics. |
| FILED | Thursday, February 07, 2019 |
| APPL NO | 16/270259 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 9/0019 (20130101) A61K 9/0051 (20130101) A61K 9/143 (20130101) Original (OR) Class A61K 9/5115 (20130101) A61K 9/7007 (20130101) A61K 31/573 (20130101) A61K 31/7088 (20130101) A61K 38/482 (20130101) A61K 39/44 (20130101) A61K 39/395 (20130101) A61K 2039/54 (20130101) A61K 2039/505 (20130101) Enzymes C12Y 304/21073 (20130101) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12171912 | Kumta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Prashant N. Kumta (Pittsburgh, Pennsylvania); Sung Jae Chung (Pittsburgh, Pennsylvania); Partha Saha (Pittsburgh, Pennsylvania); Oleg Velikokhatnyi (Pittsburgh, Pennsylvania); Moni Kanchan Datta (Pittsburgh, Pennsylvania); Dae Ho Hong (Pittsburgh, Pennsylvania); Da-Tren Chou (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular. |
| FILED | Friday, February 24, 2023 |
| APPL NO | 18/113676 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/022 (20130101) Original (OR) Class A61L 31/148 (20130101) Alloys C22C 33/10 (20130101) C22C 38/00 (20130101) C22C 38/002 (20130101) C22C 38/04 (20130101) C22C 38/14 (20130101) C22C 45/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172161 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic system includes a fluid distribution network, and a fluid collection and sampling network; a plurality of fluidic modules fluidically coupled between the fluid distribution network and the fluid collection and sampling network in parallel; a systemic circulation and mixing reservoir; and a first pump, and a second pump, wherein the first pump is fluidically coupled between the systemic circulation and mixing reservoir and the fluid distribution network for withdrawing media from the systemic circulation and mixing reservoir and delivering the media to the fluid distribution network; and wherein the second pump is fluidically coupled between the fluid collection and sampling network and a sample vial for withdrawing effluent of the plurality of fluidic modules from the fluid collection and sampling network and delivering the effluent to one or more sample vials. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015782 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 2300/123 (20130101) B01L 2400/0481 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/06 (20130101) F04B 43/14 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) F16K 2099/0084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172216 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Lianyi Chen (Madison, Wisconsin); Ali Nabaa (Madison, Wisconsin) |
| ABSTRACT | Aspects of the disclosure are directed to methods and/or apparatuses involving the formation of pore-free or nearly pore-free liquid droplets. As may be implemented in accordance with one or more embodiments, liquid droplets including metal are formed having pores within the liquid droplets. This may involve, for example, atomizing liquid metal with a gas and forming the droplets having pores. The pores are then driven out of the liquid droplets by heating the liquid droplets from a first state in which an outer surface of the droplets has a lower temperature than an inner region thereof, to a second state in which the outer surface has a higher temperature than the inner region. |
| FILED | Tuesday, August 23, 2022 |
| APPL NO | 17/893874 |
| ART UNIT | 1738 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 7/168 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/082 (20130101) Original (OR) Class B22F 2009/086 (20130101) B22F 2009/086 (20130101) B22F 2203/11 (20130101) B22F 2301/205 (20130101) B22F 2999/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172314 | Chu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen Chu (Austin, Texas); Shuai Li (Austin, Texas); Forrest Green (Austin, Texas); Peter Worsnop (Bethesda, Maryland); Andrea Lockerd Thomaz (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495633 |
| ART UNIT | 3656 — Material and Article Handling |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173012 | Wood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR UNIVERSITY (Waco, Texas) |
| ASSIGNEE(S) | BAYLOR UNIVERSITY (Waco, Texas) |
| INVENTOR(S) | John L. Wood (Waco, Texas); Ke Kong (Rockville, Maryland); Kevin Gayler (Waco, Texas) |
| ABSTRACT | Equipotent indolocarbazole-derived analogs of staurosporine identified herein are prepared through C—H borylation chemistry. Functionality resides at C2 and C10 of the indolocarbazole aromatic region. Introducing functionality in this previously inaccessible region does not abrogate kinase activity and is shown to change the selectivity profile. |
| FILED | Thursday, January 25, 2024 |
| APPL NO | 18/422175 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 498/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173027 | Yurke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho) |
| INVENTOR(S) | Bernard Yurke (Boise, Idaho) |
| ABSTRACT | Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/100052 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) C07H 21/04 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) C09B 23/06 (20130101) C09B 23/083 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173212 | Delcamp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Mississippi (University, Mississippi); Mississippi State University (Starkville, Mississippi) |
| ASSIGNEE(S) | University of Mississippi (University, Mississippi); Mississippi State University (Starkville, Mississippi) |
| INVENTOR(S) | Jared Delcamp (Oxford, Mississippi); Nathan Hammer (Oxford, Mississippi); Colleen Scott (Starkville, Mississippi) |
| ABSTRACT | In one aspect, the disclosure relates to fluorescent dyes that absorb and emit in the near infrared II (NIR II) range of the electromagnetic spectrum, methods of making same, compositions comprising same and methods of using the compositions to perform imaging on biological samples, and optoelectronic devices using the dyes. The dyes are small organic molecules that are inexpensive and facile to produce, can be water-soluble, have tunable properties, and are biocompatible and/or possess low toxicity. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407838 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 57/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173281 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Ashwin Gopinath (Pasadena, California); Paul W. K. Rothemund (Pasadena, California) |
| ABSTRACT | Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measuring target concentration, measuring effects of environmental conditions on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices include three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration in which they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices may carry DNA tags to enable separation of open and closed devices and barcoding for multiplexed detection. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542224 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2525/30 (20130101) C12Q 2525/197 (20130101) C12Q 2525/205 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5308 (20130101) G01N 2333/705 (20130101) G01N 2333/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173286 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | UNIVERSITY OF MASSACHUSETTS (Westborough, Massachusetts) |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Neil Aronin (Newtonville, Massachusetts); Julia Alterman (Worcester, Massachusetts); Matthew Hassler (Worcester, Massachusetts) |
| ABSTRACT | Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 16/927543 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/343 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) C12N 2310/3521 (20130101) C12N 2310/3533 (20130101) C12N 2320/51 (20130101) C12N 2320/53 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173291 | Romesberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Floyd E. Romesberg (La Jolla, California); Michael P. Ledbetter (La Jolla, California); Rebekah J. Karadeema (La Jolla, California) |
| ABSTRACT | Disclosed herein are methods, cells, engineered microorganisms, and kits for increasing the production of polypeptides comprising one or more unnatural amino acids. Further provided are cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913226 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 14/405 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/67 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/3125 (20130101) C12N 2800/80 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173351 | Krieg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Elisha Krieg (Dresden, United Kingdom); William M. Shih (Cambridge, Massachusetts); Dionis Minev (Cambridge, Massachusetts); Richard Guerra (Milton, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are methods and compositions for the production of long single-stranded DNA. |
| FILED | Thursday, April 11, 2019 |
| APPL NO | 17/046552 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 2523/101 (20130101) C12Q 2525/117 (20130101) C12Q 2525/131 (20130101) C12Q 2527/125 (20130101) C12Q 2531/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173361 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (, None) |
| INVENTOR(S) | Rustem F Ismagilov (Altadena, California); Jacob T Barlow (Pasadena, California); Said R Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems and related composition, to provide a rodent model having a target microbiome profile formed by a target presence, a target proportion and/or a target total load of a target prokaryote of a target taxon, based on absolute quantification of the target prokaryote. Further provided are rodents obtained by the methods herein described and related use in testing methods performed in connection with physiological or pathological conditions in an individual preferably a human individual. Also provided herein is a tailcup device and related use to prevent coprophagia in rodents. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148543 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/15 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173363 | Ismagilov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| INVENTOR(S) | Rustem F. Ismagilov (Altadena, California); Jacob T. Barlow (Pasadena, California); Said R. Bogatyrev (Pasadena, California) |
| ABSTRACT | Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure. |
| FILED | Tuesday, July 12, 2022 |
| APPL NO | 17/863183 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173593 | Alali et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eden GeoPower, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | Eden GeoPower, Inc. (Somerville, Massachusetts) |
| INVENTOR(S) | Ammar Alali (Cambridge, Massachusetts); Mehrdad Mehrvand (Somerville, Massachusetts) |
| ABSTRACT | Downhole tools, systems, and methods for electric-based fracturing are disclosed. A downhole tool for electric-based fracturing may include an outer enclosure, an insulator chamber disposed at least partially within the enclosure, and an electrode disposed at least partially within the insulator chamber. The electrode may extend out from the insulator chamber and the enclosure, and may be configured to transfer electric energy to an exterior environment surrounding the downhole tool. The insulator chamber may be configured to thermally and electrically insulate at least a portion of the electrode from the exterior environment. |
| FILED | Tuesday, April 18, 2023 |
| APPL NO | 18/136169 |
| ART UNIT | 3676 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 17/028 (20130101) E21B 43/26 (20130101) Original (OR) Class E21B 43/2401 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174016 | Jang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yoon-Soo Jang (Los Angeles, California); Chee Wei Wong (Los Angeles, California); Hao Liu (Los Angeles, California); Jinghui Yang (Los Angeles, California) |
| ABSTRACT | Systems and methods for soliton microcomb-based precision dimensional metrology via spectrally-resolved interferometry are described. In an embodiment, the system includes a dual-pumped soliton microcomb generator comprising a pump, a microresonator, and an auxiliary pump and that generates a single-soliton microcomb, an erbium-doped fiber amplifier that amplifies a C-band section of the soliton microcomb and a non-polarizing beam splitter that divides the soliton microcomb pulses into a reference arm pulse and a measurement arm pulse for an interferometer and recombines the reference arm pulse and the measurement arm pulse into a recombined beam upon their return. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 17/287061 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02008 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 17/36 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06708 (20130101) H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174164 | Jung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Byunghoo Jung (West Lafayette, Indiana); Babak Ziaie (West Lafayette, Indiana); Wuyang Yu (West Lafayette, Indiana); Weeseong Seo (West Lafayette, Indiana) |
| ABSTRACT | Systems, devices, kits, and methods for detecting and quantifying targeted compounds within a liquid (such as urine) are provided. Such systems, devices, and methods may be autonomous, noninvasive, and provide quick and accurate results. The systems and devices are at least partially disposable (single-use) and configured to be embedded within or applied to a conventional diaper or the like. Methods for using the systems and devices hereof include receiving a liquid to be tested within a portion of a disposable device, allowing the liquid to traverse through one or more channels defined within the device in a controlled fashion, reacting the liquid with one or more chemical reagents, using a sensing unit to collect photocurrent data regarding the chemical reach on(s), and wirelessly transmitting that data to a computing unit for storage and quantitative analysis. |
| FILED | Thursday, January 19, 2017 |
| APPL NO | 16/085523 |
| ART UNIT | 1796 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/42 (20130101) A61F 2013/424 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 31/227 (20130101) Original (OR) Class G01N 33/528 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174225 | Wolfowicz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Gary Wolfowicz (Paris, France); Samuel James Whiteley (Los Gatos, California); David Daniel Awschalom (Chicago, Illinois) |
| ABSTRACT | Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence. |
| FILED | Tuesday, January 24, 2023 |
| APPL NO | 18/158895 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 15/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174530 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Ratnesh Kumar (Ames, Iowa); Shawana Tabassum (Ames, Iowa); Liang Dong (Ames, Iowa) |
| ABSTRACT | A technique, and its applications, for high resolution, rapid, and simple nanopatterning. The general method has been demonstrated in several forms and applications. One is patterning nanophotonic structures at an optical fiber tip for refractive index sensing. Another is patterning nanoresonator structures on a sensor substrate for plasmonic effect related detection of VOCs. In the latter example, a graphene oxide coated plasmonic crystal as a gas sensor capable of identifying different gas species using an array of such structures. By coating the surface of multiple identical plasmonic crystals with different thicknesses of Graphene-Oxide (GO) layer, the effective refractive index of the GO layer on each plasmonic crystal is differently modulated when exposed to a specific gas. Identification of various gas species is accomplished using pattern recognition algorithm. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 16/946028 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/42 (20130101) Optical Elements, Systems, or Apparatus G02B 1/02 (20130101) G02B 1/045 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class G03F 7/2012 (20130101) G03F 7/2014 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174628 | Bronikowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Scott Alan Bronikowski (South Milwaukee, Wisconsin); Daniel Paul Barrett (South Bend, Indiana); Haonan Yu (Sunnyvale, California); Jeffrey Mark Siskind (West Lafayette, Indiana) |
| ABSTRACT | A system for directing the motion of a vehicle, comprising receiving commands in natural language using a processor, the commands specifying a relative path to be taken by the vehicle with respect to other objects in the environment; and determining an absolute path for the vehicle to follow based on the relative path using the processor, the absolute path comprising a series of coordinates in the environment; and directing the vehicle along the absolute path. Also provided is a system for training a lexicon of a natural language processing system, comprising receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of the absolute paths using a processor, and determining parameters of the lexicon based on the data set. |
| FILED | Friday, August 25, 2017 |
| APPL NO | 16/328202 |
| ART UNIT | 2833 — Electrical Circuits and Systems |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 30/10 (20130101) B60W 50/08 (20130101) B60W 50/10 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/10 (20130101) G05D 1/0033 (20130101) Original (OR) Class G05D 1/0088 (20130101) G05D 1/0221 (20130101) G05D 1/0231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174815 | Stephens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AirMettle, Inc. (Houston, Texas) |
| ASSIGNEE(S) | AirMettle, Inc. (Houston, Texas) |
| INVENTOR(S) | Donpaul C. Stephens (Houston, Texas); Joshua R. Fuhs (Columbus, Indiana) |
| ABSTRACT | A technique of partitioning compressed data includes splitting the compressed data into multiple portions. The technique further includes storing a decompression state in association with a current portion, wherein the decompression state is based on data of a previous portion and enables decompression of the current portion independently of other portions. |
| FILED | Tuesday, November 01, 2022 |
| APPL NO | 17/978609 |
| ART UNIT | 2162 — Data Bases & File Management |
| CURRENT CPC | Electric Digital Data Processing G06F 16/278 (20190101) G06F 16/1744 (20190101) G06F 16/2282 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175333 | Englund et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dirk Robert Englund (Brookline, Massachusetts); Stefan Ivanov Krastanov (Boston, Massachusetts); Hamza Raniwala (Cambridge, Massachusetts) |
| ABSTRACT | The typical approach to transfer quantum information between two superconducting quantum computers is to transduce the quantum information into the optical regime at the first superconducting quantum computer, transmit the quantum information in the optical regime to the second superconducting quantum computer, and then transduce the quantum information back into the microwave regime at the second superconducting quantum computer. However, direct microwave-to-optical and optical-to-microwave transduction have low fidelity due to the low microwave-optical coupling rates and added noise. These problems compound in consecutive microwave-to-optical and optical-to-microwave transduction steps. We break this rate-fidelity trade-off by heralding end-to-end entanglement with one detected photon and teleportation. In contrast to cascaded direct transduction, our technology absorbs the low optical-microwave coupling efficiency into the entanglement heralding step. Our approach unifies and simplifies entanglement generation between superconducting devices and other physical modalities in quantum networks. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496833 |
| ART UNIT | 2851 — Printing/Measuring and Testing |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175748 | Huo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Ke Huo (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | A method and system for localizing a plurality of stationary devices, such as Internet of Things (IoT devices), arranged in an environment is disclosed. A mobile device is configured to survey an environment to generate a three-dimensional map of the environment using simultaneous localization and mapping (SLAM) techniques. The mobile device and the stationary devices are equipped with wireless transceivers, such as Ultra-wideband radios, for measuring distances between the devices using wireless ranging techniques. Based on the measured distances, the mobile device is configured to determine locations of the stationary devices in a reference frame of the three-dimensional map. In some embodiments, the determined locations can be used to enable a variety of spatially aware augmented reality features and interactions between the mobile device and the stationary device. |
| FILED | Tuesday, September 20, 2022 |
| APPL NO | 17/933714 |
| ART UNIT | RD00 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0484 (20130101) Image Data Processing or Generation, in General G06T 11/00 (20130101) G06T 15/00 (20130101) G06T 2200/24 (20130101) Image or Video Recognition or Understanding G06V 20/20 (20220101) Original (OR) Class Wireless Communication Networks H04W 88/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176094 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| INVENTOR(S) | Charles A. Taylor (Atherton, California); Hyun Jin Kim (San Mateo, California); Jessica S. Coogan (Palo Alto, California) |
| ABSTRACT | A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 16/426877 |
| ART UNIT | 1671 — Amusement and Education Devices |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 30/00 (20180101) G16H 30/20 (20180101) Original (OR) Class G16H 30/40 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176121 | Ndukaife |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Justus C. Ndukaife (Nashville, Tennessee) |
| ABSTRACT | A nanotweezer and method of trapping and dynamic manipulation thereby are provided. The nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures arranged in an array, and a trapping region laterally displaced from the array; a second metastructure including a second substrate and a second electrode; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode; and a light source configured to selectively apply an excitation light to the microfluidic channel at a first location corresponding to the array, thereby to trap a nanoparticle at a second location corresponding to the trapping region. |
| FILED | Monday, October 02, 2023 |
| APPL NO | 18/479654 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176196 | Wysocki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Vicki Wysocki (Columbus, Ohio); Dalton Snyder (Columbus, Ohio); Benjamin Jones (Columbus, Ohio); Alyssa Stiving (Columbus, Ohio); Joshua Gilbert (Columbus, Ohio); Zachary Vanaernum (Columbus, Ohio); Sophie Harvey-Bernier (Columbus, Ohio) |
| ABSTRACT | Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel. |
| FILED | Sunday, December 15, 2019 |
| APPL NO | 17/431299 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/38 (20130101) H01J 49/061 (20130101) H01J 49/066 (20130101) H01J 49/0068 (20130101) Original (OR) Class H01J 49/426 (20130101) H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176470 | Ferrari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Lorenzo Ferrari (Portland, Oregon); Zhaowei Liu (San Diego, California) |
| ABSTRACT | A light emitting diode may include a light emission layer and a charge transport layer disposed on the light emission layer. A grating including a plurality of nanoholes may be formed by removing a portion of the charge transport layer and/or the light emission layer and depositing a plasmonic metamaterial on a remaining portion of the charge transport layer and/or the light emission layer. The nanoholes may include the plasmonic metamaterial deposited inside the recesses formed by the remaining portion of the charge transport layer and/or the light emission layer, with an additional portion of the charge transport layer disposed on top. A pitch, diameter, and/or depth of the nanoholes may be configured to maximize the quantum efficiency of the light emitting diode, especially at a microscale of less than 100 microns. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 16/994391 |
| ART UNIT | 2817 — Semiconductors/Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 5/1809 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) H01L 33/32 (20130101) H01L 33/58 (20130101) Original (OR) Class H01L 33/62 (20130101) H01L 2933/0083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176512 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Zheng Chen (San Diego, California); Yang Shi (San Diego, California) |
| ABSTRACT | A method for direct recycling of degraded lithium-ion battery (LIB) cathodes includes relithiating degraded lithium nickel cobalt manganese oxide (NCM) by mixing the cathode particles with a eutectic molten-salt solution and heating the mixture at ambient pressure over a period of time, followed by a short-time thermal annealing. Combining low-temperature relithiation using the eutectic molten-salt solution with thermal annealing provides successful regeneration and full recovery of the LIB to its original storage capacity, cycling stability and rate capability to the levels of the pristine materials. The method is useful to recycle and remanufacture degraded cathode materials for LIB or sodium-ion batteries. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/438397 |
| ART UNIT | 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176522 | Belmont et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| INVENTOR(S) | Erica Belmont (Laramie, Wyoming); Kurt Stahlfeld (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to carbon foams, processes for forming carbon foams, doped carbon composites, processes for forming doped carbon composites, and uses thereof, e.g., as electrodes. Processes described herein relate to fabrication of carbon foam and materials derived from the pyrolyzation of biomass at supercritical and subcritical conditions for CO2, N2, H2O, or combinations thereof. The process includes exposing biomass to CO2, N2, H2O, or combinations thereof under various parameters for temperature, pressure, heating rate and fluid flow rate. Silicon-carbon composites and sulfur-carbon composites for use as, e.g., electrodes, are also described. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541105 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/008 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2006/10 (20130101) C01P 2006/16 (20130101) C01P 2006/40 (20130101) Producing, e.g by Pressing Raw Materials or by Extraction From Waste Materials, Refining or Preserving Fats, Fatty Substances, e.g Lanolin, Fatty Oils or Waxes; Essential Oils; Perfumes C11B 1/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/587 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176593 | Richman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as represented by the Secretary of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Government of the United states of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| INVENTOR(S) | Brittany Richman (Laurel, Maryland); Jacob Taylor (Cambridge, Massachusetts) |
| ABSTRACT | A circulator includes a central circuit having a first superconducting island, a second superconducting island, a third superconducting island, and a central island, each in electrical communication with each other via a plurality of Josephson junctions. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477960 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/383 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) H10N 60/805 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176947 | Enhos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Kerem Enhos (Boston, Massachusetts); Emrecan Demirors (Boston, Massachusetts); Tommaso Melodia (Newton, Massachusetts) |
| ABSTRACT | A visible light communication (VLC) system transmits and receives visible light signals across a VLC channel that includes an air-water interface. A transmitter may be configured generates and transmits a visible light signal across the VLC channel to a remote device, and a signal modulator controls the transmitter to generate the visible light signal from a digital transmission signal in accordance with a modulation setting. A receiver processes a remote visible light signal received across the VLC channel from the remote device. A signal demodulator converts the remote visible light signal to a received digital signal. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/804443 |
| ART UNIT | 2635 — Digital Communications |
| CURRENT CPC | Transmission H04B 10/116 (20130101) Original (OR) Class H04B 10/516 (20130101) H04B 10/676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176973 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | Lehigh University (, None) |
| INVENTOR(S) | Yahong Rosa Zheng (Bethlehem, Pennsylvania); Xiyuan Zhu (Bethlehem, Pennsylvania) |
| ABSTRACT | An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers. |
| FILED | Friday, May 05, 2023 |
| APPL NO | 18/143839 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12177328 | Fei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Yunsi Fei (Needham, Massachusetts); Zhen Jiang (Tampa, Florida) |
| ABSTRACT | Embodiments protect against memory-based side-channel attacks by efficiently shuffling data. In an example implementation, in response to a data access request by an encryption methodology regarding a first data element from amongst a plurality of data elements stored in memory, a storage address of a second data element of the plurality is determined. This storage address is determined using (i) an address of the first data element in the memory, (ii) a permutation function, and (iii) a random number. In turn, the first data element is stored at the determined storage address of the second data element and the second data element is stored at the address of the first data element. In this way, embodiments protect encryption methodologies from memory-based side-channel attacks. |
| FILED | Tuesday, April 19, 2022 |
| APPL NO | 17/723711 |
| ART UNIT | 2492 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 12172136 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | W. S. Winston Ho (Columbus, Ohio); Yang Han (Columbus, Ohio) |
| ABSTRACT | Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membrane can comprise a support layer; and a selective polymer layer disposed on the support layer. The selective polymer layer can comprise a selective polymer matrix (e.g., hydrophilic polymer, an amine-containing polymer, a low molecular weight amino compound, a CO2-philic ether, or a combination thereof), and graphene oxide dispersed within the selective polymer matrix. The membranes can be used to separate carbon dioxide for hydrogen. Also provided are methods of purifying syngas using the membranes described herein. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/288751 |
| ART UNIT | 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0006 (20130101) B01D 69/02 (20130101) B01D 69/107 (20220801) B01D 69/125 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/0211 (20220801) B01D 71/0212 (20220801) B01D 71/601 (20220801) B01D 2323/30 (20130101) B01D 2325/36 (20130101) B01D 2325/341 (20220801) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 1/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172214 | Buresh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GE Infrastructure Technology LLC (Greenville, South Carolina) |
| INVENTOR(S) | Steve J. Buresh (Niskayuna, New York); Shenyan Huang (Niskayuna, New York) |
| ABSTRACT | The present application provides a container for use in manufacturing a metal billet from a metal powder in a hot isostatic pressing process. The container may include a top, a bottom, a wall extending between the top and the bottom, an enhanced directional consolidation feature in the wall, and a sleeve positioned about the enhanced directional consolidation feature. |
| FILED | Monday, September 26, 2022 |
| APPL NO | 17/935208 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/054 (20220101) B22F 3/15 (20130101) Original (OR) Class B22F 3/1208 (20130101) B22F 2003/153 (20130101) B22F 2301/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172300 | Dilday, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel R. Dilday, Jr. (Plainfield, Illinois); Roberto T. Reyes (Ottawa, Illinois); Stanley Weidmeyer (Glen Ellyn, Illinois) |
| ABSTRACT | The invention provides a system for preventing fluid exchange between the interior and exterior of containment enclosures such as process-, hazard-, and research-enclosure systems generally, gloveboxes, containment systems, isolation systems, confinement systems, cleanrooms, negative air systems, and positive air system areas while simultaneously providing material transfer into and out of the enclosures. The invention also provides a method for transporting material into or out of a containment structure. |
| FILED | Thursday, March 10, 2022 |
| APPL NO | 17/692029 |
| ART UNIT | 3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 1/02 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 21/02 (20130101) Original (OR) Class Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 7/047 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172367 | Sauers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Aaron Sauers (Aurora, Illinois); Robert Kephart (Pioneer, California) |
| ABSTRACT | A method and system for in situ cross-linking of polymers, Bitumen, and other materials to produce arbitrary functional or ornamental three-dimensional features using electron beams provided by mobile accelerators comprises defining a desired pattern for imparting on a target area, mapping the target area, defining at least one discrete voxel in the target area according to the desired pattern to be imparted on the target area, assigning an irradiation value to each of the at least one discrete voxels, and delivering a dose of irradiation to each of the at least one discrete voxels according to the assigned irradiation value. |
| FILED | Thursday, December 14, 2023 |
| APPL NO | 18/540152 |
| ART UNIT | 3671 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) Original (OR) Class B29C 64/264 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/24 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Construction Of, or Surfaces For, Roads, Sports Grounds, or the Like; Machines or Auxiliary Tools for Construction or Repair E01C 11/005 (20130101) E01C 23/14 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/06 (20130101) H01J 37/305 (20130101) H01J 37/1472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172976 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Zhen Cheng (Mountain View, California); Hao Chen (Shanghai, China PRC) |
| ABSTRACT | Provided are delocalized lipophilic cation (DLC) compounds and methods of using such compounds. Also provided are pharmaceutical compositions that include a DLC compound. Provided methods include methods of killing cells and methods of fluorescently labeling mitochondria by contacting the cells with a DLC compound of the present disclosure. Also provided are methods of imaging cell mitochondria, methods of determining whether a patient has a mitochondria related disease, and methods of treating a patient for a mitochondria related disease. Kits that include compounds of the present disclosure are also provided. |
| FILED | Friday, January 10, 2020 |
| APPL NO | 17/420254 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 401/06 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173040 | Zamora et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ferring B.V. (Hoofddorp, Netherlands); Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | Ferring B.V. (Hoofddorp, Netherlands); Brookhaven Science Associates, LLC (, None) |
| INVENTOR(S) | Paul O. Zamora (Gaithersburg, Maryland); Brent Lee Atkinson (Highlands Ranch, Colorado); Xinhua Lin (Plainview, New York); Louis A. Pena (Poquott, New York) |
| ABSTRACT | A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/443012 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/16 (20130101) A61L 27/16 (20130101) A61L 27/22 (20130101) A61L 27/24 (20130101) A61L 27/34 (20130101) A61L 27/34 (20130101) A61L 27/227 (20130101) A61L 27/507 (20130101) A61L 2430/02 (20130101) Peptides C07K 14/51 (20130101) C07K 14/4705 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 27/18 (20130101) C08L 89/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173245 | Sumant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anirudha V. Sumant (Plainfield, Illinois); Venkata Aditya Ayyagari (Darien, Illinois) |
| ABSTRACT | A low friction wear surface with a coefficient of friction in the superlubric regime under a sliding and rolling movement. The low friction wear surface includes molybdenum disulfide and graphene oxide on a first wear surface with a tribolayer formed on a rough steel counter surface during the sliding and rolling movement. Methods of producing the low friction wear surface are also provided. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/351817 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 103/02 (20130101) C10M 103/06 (20130101) Original (OR) Class C10M 2201/0413 (20130101) C10M 2201/0663 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2040/02 (20130101) C10N 2040/12 (20130101) C10N 2040/18 (20130101) C10N 2040/24 (20130101) C10N 2040/30 (20130101) C10N 2040/50 (20200501) C10N 2050/08 (20130101) C10N 2070/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173276 | Dahlin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Lukas Royce Dahlin (Golden, Colorado); Michael T. Guarnieri (Denver, Colorado) |
| ABSTRACT | Phosphite dehydrogenase (ptxD) expression was established as a selectable marker for nuclear and chloroplast genetic selection in Picochlorum renovo and Picochlorum celeri Phosphite was used as a sole phosphorus source in P. renovo and P. celeri. Growth on phosphite led to comparable growth and composition relative to phosphate. |
| FILED | Friday, September 23, 2022 |
| APPL NO | 17/951848 |
| ART UNIT | 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/12 (20130101) Original (OR) Class C12N 9/0004 (20130101) C12N 15/8214 (20130101) C12N 15/8243 (20130101) C12N 2800/10 (20130101) Enzymes C12Y 120/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173416 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Giner, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | GINER, INC. (Newton, Massachusetts) |
| INVENTOR(S) | Hui Xu (Acton, Massachusetts); Andrew Sweet (Boxborough, Massachusetts); Winfield Greene (Lexington, Massachusetts); Kailash Patil (Lincoln, Massachusetts) |
| ABSTRACT | A composite membrane that is suitable for use in a molten alkaline water electrolyzer. In one embodiment, the composite membrane includes a porous support, the porous support being in the form of a matrix of metal oxide particles randomly arranged to form a plurality of tortuous pores. The composite membrane also includes molten electrolyte filling the pores of the porous support, the molten electrolyte having hydroxide ion conductivity. The molten electrolyte may be a single species of an alkali hydroxide or of an alkaline earth hydroxide. Alternatively, the molten electrolyte may be a eutectic or non-eutectic mixture of two or more species of alkali hydroxides or alkaline earth hydroxides. The composite membrane may further include one or more additives, such as a coarsening inhibitor, a crack attenuator, and a reinforcing material. The composite material may be used to make a molten alkaline membrane water electrolyzer with high electrical efficiencies. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 16/590266 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 9/73 (20210101) C25B 13/02 (20130101) Original (OR) Class C25B 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173624 | Sobanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RTX CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Jon E. Sobanski (Glastonbury, Connecticut); Neil J. Terwilliger (Cheshire, Connecticut) |
| ABSTRACT | A turbine engine is provided that includes a bypass flowpath, a plurality of upstream vanes and a plurality of downstream vanes. The bypass flowpath is fluidly coupled with and downstream of a fan section. The bypass flowpath bypasses a turbine engine core. The upstream vanes are arranged circumferentially about an axis in an upstream vane array. Each of the upstream vanes extends radially across the bypass flowpath. The downstream vanes are arranged circumferentially about the axis in a downstream vane array. The downstream vanes are circumferentially interspersed with the upstream vanes. Each of the downstream vanes extends radially across the bypass flowpath. A first of the downstream vanes is axially offset from a first of the upstream vanes along the axis. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/199742 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/065 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/141 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/12 (20130101) F05D 2260/213 (20130101) F05D 2260/606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173651 | Terwilliger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RTX CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Neil J. Terwilliger (Cheshire, Connecticut); Simon W. Evans (Farmington, Connecticut) |
| ABSTRACT | A propulsion system is provided for an aircraft. This propulsion system includes a turbine engine, and the turbine engine includes a propulsor rotor, an engine core and a heat exchanger. The propulsor rotor is configured to rotate about an axis and direct a first air stream along a primary flowpath that bypasses the engine core. The propulsor rotor is configured to direct a second air stream along a secondary flowpath with a geometry extending at least eighty degrees about the axis. The turbine engine is configured such that the first air stream enters the primary flowpath at a first pressure and the second air stream enters the secondary flowpath at a second pressure that is different than the first pressure. The engine core is configured to drive rotation of the propulsor rotor. The heat exchanger is disposed within the secondary flowpath. |
| FILED | Monday, May 15, 2023 |
| APPL NO | 18/197558 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) F02C 7/042 (20130101) Original (OR) Class F02C 7/141 (20130101) F02C 7/185 (20130101) Jet-propulsion Plants F02K 1/06 (20130101) F02K 3/06 (20130101) F02K 3/077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174067 | Kester |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REBELLION PHOTONICS, INC. (Houston, Texas) |
| ASSIGNEE(S) | REBELLION PHOTONICS, INC. (Houston, Texas) |
| INVENTOR(S) | Robert Timothy Kester (Friendswood, Texas) |
| ABSTRACT | In one embodiment, an infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including an optical focal plane array (FPA) unit. The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. Said optical system and said processing unit can be contained together in a data acquisition and processing module configured to be worn or carried by a person. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/302306 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/02 (20130101) G01J 3/28 (20130101) G01J 3/0208 (20130101) G01J 3/0232 (20130101) Original (OR) Class G01J 3/0256 (20130101) G01J 3/0286 (20130101) G01J 3/0289 (20130101) G01J 3/0297 (20130101) G01J 3/2803 (20130101) G01J 5/02 (20130101) G01J 5/07 (20220101) G01J 5/0014 (20130101) G01J 5/026 (20130101) G01J 5/047 (20130101) G01J 5/061 (20130101) G01J 5/0804 (20220101) G01J 2003/104 (20130101) G01J 2003/1217 (20130101) G01J 2003/1221 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3504 (20130101) Optical Elements, Systems, or Apparatus G02B 5/201 (20130101) G02B 5/208 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 23/45 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174515 | Demory et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Brandon Demory (Tracy, California); Tiziana C. Bond (Livermore, California); Clint Frye (Livermore, California); Lars Voss (Livermore, California) |
| ABSTRACT | Amorphous silicon carbide may be doped with one or more ions such as vanadium and these ions may radiate light if excited, for example, using optical or electrical pumping. A single photon light source may be formed from a single such ion that is pumped or from a plurality of ions that are pumped if light from only one ion is collected, e.g., using an aperture or pin hole. Such single photon sources may possibly be use in quantum computing, quantum sensing and/or quantum telecommunications. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/655983 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2004/03 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/698 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 2/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176113 | Reid |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Robert Stowers Reid (Santa Fe, New Mexico) |
| ABSTRACT | A heat pipe cooled nuclear reactor core (“reactor core”) includes an array of fuel, an array of primary heat rejection heat pipes, and an array of moderator cooling heat pipes or thermosiphons. Each moderator cooling heat pipe in the array of moderator cooling heat pipes is surrounded by metal hydride moderator materials, slowing neutrons from a fission energy range to a lower energy range in the reactor core. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176752 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Nuclear Reactors G21C 5/02 (20130101) G21C 15/02 (20130101) G21C 15/04 (20130101) G21C 15/08 (20130101) Original (OR) Class G21C 15/257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176114 | Youchison et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Dennis L. Youchison (Oak Ridge, Tennessee); Brian Williams (Camarillo, California) |
| ABSTRACT | A nuclear fuel element is provided. The nuclear fuel element includes a porous support. The porous support includes a ligament and defines a pore adjacent to the ligament. The ligament has an interior surface spaced from the pore. The interior surface defines a void. The porous support includes silicon carbide. The nuclear fuel element includes a nuclear fuel material disposed in the pore. The nuclear fuel material includes a moderator and tri-structural isotropic (TRISO) particles. Another nuclear fuel element is provided. The nuclear fuel element includes a porous support. The porous support includes a ligament and defines a pore adjacent to the ligament. The ligament has an interior surface spaced from the pore. The interior surface defines a void. The ligament includes the nuclear fuel material. The nuclear fuel element includes a facesheet overlying the porous support and defines a hole. The hole is in fluid communication with the void. The nuclear fuel material includes a nuclear fuel. |
| FILED | Tuesday, March 07, 2023 |
| APPL NO | 18/118390 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Nuclear Reactors G21C 3/044 (20130101) Original (OR) Class G21C 3/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176125 | Yin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE Aviation Systems LLC (Grand Rapids, Michigan) |
| ASSIGNEE(S) | GE AVIATION SYSTEMS LLC (Grand Rapids, Michigan) |
| INVENTOR(S) | Weijun Yin (Niskayuna, New York) |
| ABSTRACT | A method of manufacturing an insulated conductive component having an electrically conductive element is provided. The method includes applying a first layer of a first material comprising a thermally conductive ceramic on a portion of the conductive element, and applying a second layer of a second material comprising a polymeric resin over the first layer. The method includes curing the conductive element to infuse the second material into the first material to define an electrically insulative, thermally conductive coating on the portion of the electrically conductive element. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/929571 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/185 (20130101) B05D 3/067 (20130101) B05D 3/068 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 13/003 (20130101) H01B 13/16 (20130101) Original (OR) Class H01B 13/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176171 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jian Liu (Blacksburg, Virginia); Lakshmi Ravi (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Steven Schmalz (Waukesha, Wisconsin) |
| ASSIGNEE(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| INVENTOR(S) | Jian Liu (Blacksburg, Virginia); Lakshmi Ravi (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Steven Schmalz (Waukesha, Wisconsin) |
| ABSTRACT | Gate control of power semiconductor devices using reduced gate drivers is disclosed. A circuit breaker may include a multitude of transistors, such as insulated gate bipolar transistors (IGBTs), connected in series with one another. Each transistor may be connected to a respective gate resistor. Diodes may be connected between various gate resistors. One or more resistor-capacitor (RC) snubber circuits may be provided in parallel with one or more of the transistors. Likewise, one or more metal-oxide varistors (MOVs) may be connected in parallel to one or more of the transistors. A gate driver (e.g., a single gate drive) may be connected to the one or more diodes and an emitter of at least one of transistors. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/885130 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 9/542 (20130101) Original (OR) Class H01H 33/596 (20130101) H01H 2009/543 (20130101) H01H 2009/544 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176523 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Christopher S. Johnson (Naperville, Illinois); Eungje Lee (Naperville, Illinois); Jinhyup Han (Woodridge, Illinois); Jehee Park (Woodridge, Illinois) |
| ABSTRACT | Lead/lead oxide/carbon (“Pb—O—C”) nanocomposite materials that are useful as electrode active materials for electrodes in lithium and sodium batteries are formed by grinding a mixture of a lead oxide material and a carbon material in a high energy ball mill. A Pb—O—C nanocomposite as described herein comprises Pb and lead oxide nanoparticles homogeneously dispersed in a carbon nanoparticle matrix. In the nanocomposite, other elements (e.g., transition metals, Al, Si, P, Sn, Sb, and Bi) can be alloyed with the Pb nanoparticles, incorporated as a mixed oxide with the lead oxide nanoparticles, or can be present as distinct elemental or oxide nanoparticles within the carbon nanoparticle matrix. |
| FILED | Friday, January 13, 2023 |
| APPL NO | 18/096768 |
| ART UNIT | 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/57 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176541 | Su et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Chi Cheung Su (Westmont, Illinois); Jiayan Shi (Woodridge, Illinois); Rachid Amine (Bolingbrook, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | An electrochemical cell includes an anode that includes silicon, a conductive carbon, a lithium titanate, lithium metal, or a combination of any two or more thereof; a separator; a cathode having a cathode active material and a redox active species either mixed into the cathode or coated onto the cathode; and an electrolyte that includes a salt; and an aprotic solvent comprising a fluorinated ether solvent, a carbonate solvent, or a mixture thereof, with the proviso that the redox active species has substantially no solubility in the electrolyte. The redox active species may be a redox active organic compound or polymer. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/592635 |
| ART UNIT | 1728 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/606 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176572 | Archer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Lynden A. Archer (Ithaca, New York); Qing Zhao (Tianjin, China PRC); Kasim Khan (Ithaca, New York); Xiaotun Liu (Ithaca, New York) |
| ABSTRACT | Provided are compositions including one or more cyclic ether(s), one or more salt(s), which may be one or more lithium salt(s), one or more sodium salt(s), or a combination thereof, and, optionally, one or more ring-opening polymerization initiator(s). The compositions may be used to form solid-state electrolytes. Also provided are methods for forming solid-state electrolytes using the compositions and devices comprising one or more composition(s) or one or more solid-state electrolyte(s) using the compositions. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 17/420595 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 11/56 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 10/0565 (20130101) H01M 10/0569 (20130101) H01M 50/403 (20210101) H01M 50/409 (20210101) H01M 50/414 (20210101) Original (OR) Class H01M 50/489 (20210101) H01M 50/497 (20210101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176590 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS Tech, Inc. (Wilsonville, Oregon) |
| ASSIGNEE(S) | ESS TECH, INC. (Wilsonville, Oregon) |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Craig E. Evans (West Linn, Oregon) |
| ABSTRACT | A method of cleansing a redox flow battery system may include operating the redox flow battery system in a charge, discharge, or idle mode, and responsive to a redox flow battery capacity being less than a threshold battery capacity, mixing the positive electrolyte with the negative electrolyte. In this way, battery capacity degradation following cyclic charging and discharging of the redox flow battery system can be substantially reduced. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/645293 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 40/1306 (20220101) G06V 40/1394 (20220101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/0693 (20130101) H01M 8/04186 (20130101) H01M 8/04611 (20130101) H01M 8/04932 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176805 | Afridi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| INVENTOR(S) | Khurram K. Afridi (Boulder, Colorado); Usama Anwar (Los Angeles, California); Dragan Maksimovic (Boulder, Colorado); Robert W. Erickson (Boulder, Colorado) |
| ABSTRACT | A control architecture that overcomes limitations of conventional ac-dc converters and enables bidirectional active and reactive power processing is provided. In one implementation, for example, this may be achieved through the use of unrectified sensed ac signals in the generation of the control commands for the converter. This control architecture, in this example implementation, eliminates or at least reduces zero crossing distortions in the ac current of the converter even with relatively low bandwidth controllers. The concept can be applied to different power stage topologies. |
| FILED | Wednesday, March 21, 2018 |
| APPL NO | 15/927918 |
| ART UNIT | 2838 — Electrical Circuits and Systems |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/70 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/4233 (20130101) Original (OR) Class H02M 7/797 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178130 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Renkun Chen (San Diego, California); Sahngki Hong (La Jolla, California) |
| ABSTRACT | Thermoelectric devices (TE) devices may be used to power wearable electronics, such as watches and sensors by harvesting heat from the body. These TE devices may fully power or partially power the wearable devices to extend a usage time, or to recharge a battery. In other example embodiments, TE devices can be used to provide heating and/or cooling. The TE devices can be integrated into garments such as clothes, vests, and armbands for outdoor and indoor environments. For outdoor environments, applications include, but are not limited to, sports such as golfing, bicycling, running, walking, training, soccer, hiking, and other outdoor activities related to occupations, such as construction, fire-fighting, military operations, law enforcement, farming, underground mining, and so on. In other example embodiments, TE devices can be used to provide thermal camouflaging for people and objects so as to not be seen by thermal imaging devices. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/295851 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 31/04 (20190201) Electric solid-state devices not otherwise provided for H10N 10/01 (20230201) H10N 10/13 (20230201) H10N 10/17 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 12171512 | Mondry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Jack Mondry (Edina, Minnesota); Shane Farritor (Lincoln, Nebraska); Eric Markvicka (Brush, Colorado); Thomas Frederick (Lincoln, Nebraska); Joe Bartels (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly. |
| FILED | Thursday, October 12, 2023 |
| APPL NO | 18/485601 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 34/20 (20160201) A61B 34/30 (20160201) Original (OR) Class A61B 90/361 (20160201) A61B 2017/2906 (20130101) A61B 2034/302 (20160201) A61B 2034/2048 (20160201) A61B 2034/2051 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0084 (20130101) B25J 9/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172161 | Reiserer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A fluidic system includes a fluid distribution network, and a fluid collection and sampling network; a plurality of fluidic modules fluidically coupled between the fluid distribution network and the fluid collection and sampling network in parallel; a systemic circulation and mixing reservoir; and a first pump, and a second pump, wherein the first pump is fluidically coupled between the systemic circulation and mixing reservoir and the fluid distribution network for withdrawing media from the systemic circulation and mixing reservoir and delivering the media to the fluid distribution network; and wherein the second pump is fluidically coupled between the fluid collection and sampling network and a sample vial for withdrawing effluent of the plurality of fluidic modules from the fluid collection and sampling network and delivering the effluent to one or more sample vials. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 18/015782 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 2300/123 (20130101) B01L 2400/0481 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/06 (20130101) F04B 43/14 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0057 (20130101) F16K 2099/0084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172660 | Samani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Saeideh E. Samani (Williamsburg, Virginia); Richard K. Jessop (Hampton, Virginia); Angela R. Harrivel (Poquoson, Virginia); Chad L. Stephens (Poquoson, Virginia); Alan T. Pope (Poquoson, Virginia); Kellie D. Kennedy (Poquoson, Virginia) |
| ABSTRACT | A dynamic function allocation (DFA) framework balances the workload or achieves other mitigating optimizations for a human operator of a vehicle by dynamically distributing operational functional tasks between the operator and the vehicle's or robot's automation in real-time. DFA operations include those for aviation, navigation, and communication, or to meet other operational needs. The DFA framework provides an intuitive command/response interface to vehicle (e.g., aircraft), vehicle simulator, or robotic operations by implementing a Dynamic Function Allocation Control Collaboration Protocol (DFACCto). DFACCto simulates or implements autonomous control of robot's or vehicle's functional tasks and reallocates some or all tasks between a human pilot and an autonomous system when such reallocation is preferred, and implements the reallocation. The reallocation is implemented in the event of the human's distraction or incapacitation, in the event another non-nominal or non-optimal cognitive or physical state is detected, or when reallocation need is otherwise-determined. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685027 |
| ART UNIT | 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/08 (20130101) B60W 50/14 (20130101) Original (OR) Class B60W 60/001 (20200201) B60W 2040/0818 (20130101) B60W 2050/0001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172767 | Resnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Parallel Flight Technologies, Inc. (Ben Lomond, California) |
| ASSIGNEE(S) | Parallel Flight Technologies, Inc. (Ben Lomond, California) |
| INVENTOR(S) | Joshua Resnick (Ben Lomond, California); David Adams (Ben Lomond, California); Robert Hulter (Ben Lomond, California); Seth McGann (Ben Lomond, California); Brian Eiseman (Ben Lomond, California) |
| ABSTRACT | One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/474004 |
| ART UNIT | 3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 7/10 (20130101) B60L 15/20 (20130101) B60L 58/12 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/32 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 27/026 (20240101) B64D 27/40 (20240101) B64D 31/06 (20130101) Original (OR) Class B64D 33/08 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/14 (20230101) B64U 20/94 (20230101) B64U 20/96 (20230101) B64U 30/29 (20230101) B64U 50/11 (20230101) B64U 50/19 (20230101) B64U 60/50 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173027 | Yurke |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho) |
| INVENTOR(S) | Bernard Yurke (Boise, Idaho) |
| ABSTRACT | Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/100052 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) C07H 21/04 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 11/08 (20130101) C09B 23/06 (20130101) C09B 23/083 (20130101) Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173934 | Sercel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trans Astronautica Corporation (Lake View Terrace, California) |
| ASSIGNEE(S) | Trans Astronautica Corporation (Lake View Terrace, California) |
| INVENTOR(S) | Joel C. Sercel (Lake View Terrace, California); Craig Peterson (Los Angeles, California); Anthony Longman (Woodland Park, Colorado) |
| ABSTRACT | Systems and methods are disclosed for directing radiant energy to permanently shadowed or occasionally shadowed regions such as on the floors of craters or in valleys in lunar polar regions to provide illumination, thermal power, electricity, communications, and other services. Embodiments of the systems include reflector elements to provide diffuse illumination, focused illumination, and thermal power, structures to support the reflectors and other elements, communications devices for varied signal types, and methods for installing the system. The structure can be compactly folded and delivered to be automatically installed. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205610 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) F24S 20/60 (20180501) F24S 23/70 (20180501) Original (OR) Class F24S 50/20 (20180501) F24S 2020/23 (20180501) F24S 2023/872 (20180501) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) H02S 30/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12174259 | Mehrotra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of the National Aeronautics and Space (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Angad Mehrotra (Houston, Texas); John J. Darst (Houston, Texas); Eric Darcy (Houston, Texas); Romil Patil (Houston, Texas); Safan Abbasi (Arlington, Virginia) |
| ABSTRACT | A method for testing a battery cell includes directing a laser radiation from a laser at a radiation-receiving location on a can of the battery cell to trigger a thermal runaway event. A power, a wavelength, and a beam size of the laser radiation are selected based on a test stability of the battery cell when triggering the thermal runaway event. The test stability includes a likelihood that the can will breach in response to triggering the thermal runaway event. The method also includes ceasing to contact the radiation-receiving location with the laser radiation in response to the thermal runaway event. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/952885 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/4285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12176542 | Komatsu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nissan North America, Inc. (Franklin, Tennessee) |
| ASSIGNEE(S) | Nissan North America, Inc. (Franklin, Tennessee); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Hideyuki Komatsu (San Diego, California); Shigemasa Kuwata (Palo Alto, California); Balachandran Gadaguntla Radhakrishnan (San Mateo, California); Maarten Sierhuis (San Francisco, California); Naoki Ueda (Kanagawa, Japan); Kazuyuki Sakamoto (Kanagawa, Japan); John Lawson (San Francisco, California) |
| ABSTRACT | A method of manufacturing an all-solid-state battery cell includes depositing an interlayer directly onto an anode current collector; depositing a solid electrolyte onto the interlayer opposite the anode current collector; forming a cathode on the solid electrolyte opposite the interlayer, wherein the cathode contains one or more lithium-containing compounds; and applying pressure to achieve uniform contact between layers. The manufactured all-solid-state battery cell is anode-free prior to charging. The interlayer is configured such that lithium metal is deposited between the interlayer and the anode current collector during charging, the interlayer prevents contact between the lithium metal and the solid electrolyte, and the interlayer has a greater density than a density of the solid electrolyte. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404541 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/043 (20130101) H01M 4/62 (20130101) Original (OR) Class H01M 4/0404 (20130101) H01M 4/0423 (20130101) H01M 4/662 (20130101) H01M 2004/021 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 12172314 | Chu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen Chu (Austin, Texas); Shuai Li (Austin, Texas); Forrest Green (Austin, Texas); Peter Worsnop (Bethesda, Maryland); Andrea Lockerd Thomaz (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495633 |
| ART UNIT | 3656 — Material and Article Handling |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 15/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12172767 | Resnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Parallel Flight Technologies, Inc. (Ben Lomond, California) |
| ASSIGNEE(S) | Parallel Flight Technologies, Inc. (Ben Lomond, California) |
| INVENTOR(S) | Joshua Resnick (Ben Lomond, California); David Adams (Ben Lomond, California); Robert Hulter (Ben Lomond, California); Seth McGann (Ben Lomond, California); Brian Eiseman (Ben Lomond, California) |
| ABSTRACT | One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/474004 |
| ART UNIT | 3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 7/10 (20130101) B60L 15/20 (20130101) B60L 58/12 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/32 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 27/026 (20240101) B64D 27/40 (20240101) B64D 31/06 (20130101) Original (OR) Class B64D 33/08 (20130101) Unmanned aerial vehicles [UAV]; equipment therefor B64U 10/14 (20230101) B64U 20/94 (20230101) B64U 20/96 (20230101) B64U 30/29 (20230101) B64U 50/11 (20230101) B64U 50/19 (20230101) B64U 60/50 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12173018 | Burns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | VENATORX PHARMACEUTICALS, INC. (Malvern, Pennsylvania) |
| INVENTOR(S) | Christopher J. Burns (Malvern, Pennsylvania); Denis Daigle (Street, Maryland); Guo-Hua Chu (Exton, Pennsylvania); Jodie Hamrick (New Holland, Pennsylvania); Steven A. Boyd (Chester Springs, Pennsylvania); Allison L Zulli (Chesterbrook, Pennsylvania); Eugen F. Mesaros (Wallingford, Pennsylvania); Stephen M. Condon (Glenmoore, Pennsylvania); Robert E. Lee Trout (Collegeville, Pennsylvania); Cullen L. Myers (Exton, Pennsylvania); Zhenrong Xu (Chalfont, Pennsylvania) |
| ABSTRACT | Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/057593 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12175889 | Bell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Future Engineers (Burbank, California) |
| ASSIGNEE(S) | Future Engineers (Burbank, California) |
| INVENTOR(S) | Deanne Bell (Burbank, California) |
| ABSTRACT | A system for managing innovation challenges includes a computing apparatus having a processor and a memory with computer readable program code, wherein the processor under control of the computer readable program code is configured to implement, a content management system that operates to automatically generate an innovation challenge for students based on a common template that includes student eligibility requirements, a user management system that operates to collect user information, obtains parental or guardian consent, and determines individual student eligibility for specific innovation challenges, a submission management system that operates to automate ingestion, display, storage, and judging of challenge entry submissions, and a dashboard display that operates to manage innovation challenge participation. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094977 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06398 (20130101) G06Q 50/20 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 12176593 | Richman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as represented by the Secretary of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Government of the United states of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| INVENTOR(S) | Brittany Richman (Laurel, Maryland); Jacob Taylor (Cambridge, Massachusetts) |
| ABSTRACT | A circulator includes a central circuit having a first superconducting island, a second superconducting island, a third superconducting island, and a central island, each in electrical communication with each other via a plurality of Josephson junctions. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477960 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/383 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 60/12 (20230201) H10N 60/805 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 12175889 | Bell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Future Engineers (Burbank, California) |
| ASSIGNEE(S) | Future Engineers (Burbank, California) |
| INVENTOR(S) | Deanne Bell (Burbank, California) |
| ABSTRACT | A system for managing innovation challenges includes a computing apparatus having a processor and a memory with computer readable program code, wherein the processor under control of the computer readable program code is configured to implement, a content management system that operates to automatically generate an innovation challenge for students based on a common template that includes student eligibility requirements, a user management system that operates to collect user information, obtains parental or guardian consent, and determines individual student eligibility for specific innovation challenges, a submission management system that operates to automate ingestion, display, storage, and judging of challenge entry submissions, and a dashboard display that operates to manage innovation challenge participation. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/094977 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06398 (20130101) G06Q 50/20 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/00 (20130101) G09B 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 12177968 | Rogers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | John E. Rogers (Owens Cross Roads, Alabama); John D. Williams (Decatur, Alabama) |
| ABSTRACT | A flexible electronics assembly including a substrate including one or more dielectrics. A cavity is formed within the substrate. A first ground plane is secured to the substrate. One or more stress channels are formed through one or more portions of the substrate and the first ground plane. An electronics component is disposed within the cavity. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 16/839565 |
| ART UNIT | 2847 — Electrical Circuits and Systems |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/05 (20130101) H05K 1/115 (20130101) H05K 1/189 (20130101) H05K 1/0271 (20130101) H05K 1/0281 (20130101) Original (OR) Class H05K 1/0393 (20130101) H05K 2201/05 (20130101) H05K 2201/093 (20130101) H05K 2201/0183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 12173314 | Siprashvili et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Zurab Siprashvili (San Mateo, California); Ngon T. Nguyen (Union City, California); M. Peter Marinkovich (Redwood City, California); Jean Tang (Stanford, California); Alfred T. Lane (Los Altos, California); Paul A. Khavari (Palo Alto, California) |
| ABSTRACT | Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet. |
| FILED | Tuesday, January 03, 2017 |
| APPL NO | 16/066253 |
| ART UNIT | 1638 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0629 (20130101) Original (OR) Class C12N 2510/00 (20130101) C12N 2760/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 12172038 | Westendorf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn Westendorf (Vancouver, Canada); Stefanie Zentelis (Vancouver, Canada); Krithika Muthuraman (Toronto, Canada); Kevin Jepson (Vancouver, Canada); Ester Falconer (North Vancouver, Canada); John Mascola (Bethesda, Maryland); Barney Graham (Bethesda, Maryland); Kizzmekia Corbett (Bethesda, Maryland); Julie Ledgerwood (Bethesda, Maryland); Lingshu Wang (Bethesda, Maryland); Olubukola Abiona (Bethesda, Maryland); Wei Shi (Bethesda, Maryland); Wing-pui Kong (Bethesda, Maryland); Yi Zhang (Bethesda, Maryland); Bryan Edward Jones (San Diego, California); Denisa Foster (San Diego, California); Julian Davies (La Jolla, California); Qing Chai (San Diego, California); Christopher Carl Frye (Bargersville, Indiana); Ganapathy Gopalrathnam (Fishers, Indiana); Jörg Hendle (San Diego, California); John Michael Sauder (Carlsbad, California); Jeffrey Streetman Boyles (Indianapolis, Indiana); Anna Pustilnik (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Friday, March 31, 2023 |
| APPL NO | 18/194105 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/02 (20130101) A61K 47/26 (20130101) A61K 47/68 (20170801) A61K 47/183 (20130101) A61K 47/6801 (20170801) Original (OR) Class A61K 47/6841 (20170801) A61K 2039/54 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Peptides C07K 16/1003 (20230801) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Smithsonian Institution (SI)
| US D1055317 | Kopp |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Smithsonian Institution (Washington, District of Columbia) |
| ASSIGNEE(S) | Smithsonian Institution (Washington, District of Columbia) |
| INVENTOR(S) | Graham Michael Kopp (Herndon, Virginia) |
| ABSTRACT | |
| FILED | Tuesday, June 21, 2022 |
| APPL NO | 29/843444 |
| ART UNIT | 2912 — Design |
| CURRENT CPC | Building units and construction elements D25/123 |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 12175406 | Dearing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia); Carla F. Sherry (Annandale, Virginia) |
| ABSTRACT | Embodiments include systems and methods of a service that allows hard copy and electronic media customers to proactively specify, across a broad range of categories, the hard copy mail and/or electronic media mail that they would or would not like to receive. Embodiments include methods and systems configured to allow customers of delivery services to customize the flow of physical items such as hard copy or other letters or parcels, for delivery or electronic media mail from mailers based on highly specific customer-designated criteria. The delivery service acts as a trusted third party to serve as the intermediary between the recipient of the items and mailers to provide privacy and manage a repository for a customer-selected criteria database. In addition, one embodiment provides verification and/or identification that mail being sent meets the customer's designated criteria. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/829178 |
| ART UNIT | 3685 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/00 (20130101) Electric Digital Data Processing G06F 16/245 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) Original (OR) Class G06Q 2220/00 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 51/212 (20220501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 24, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20241224.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page