FedInvent™ Patents
Patent Details for Tuesday, December 31, 2024
This page was updated on Tuesday, December 31, 2024 at 06:10 PM GMT
Department of Health and Human Services (HHS)
| US 12178509 | Alvarez et al. |
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| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Tara Lynn Alvarez (Whippany, New Jersey); Chang Yaramothu (Fanwood, New Jersey); John Vito d'Antonio-Bertagnolli (Mount Laurel, New Jersey); Mitchell Scheiman (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Exemplary embodiments relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253300 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/005 (20130101) A61B 3/08 (20130101) Original (OR) Class A61B 3/032 (20130101) A61B 3/113 (20130101) A61B 5/7267 (20130101) Optical Elements, Systems, or Apparatus G02B 30/36 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178588 | Grover et al. |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Pulkit Grover (Pittsburgh, Pennsylvania); Alireza Chamanzar (Pittsburgh, Pennsylvania); Marlene Behrmann Cohen (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel method for using the widely-used electroencephalography (EEG) systems to detect and localize silences in the brain is disclosed. The method detects the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. This method can also be used for reduced activity localization, activity level mapping throughout the brain, as well as mapping activity levels in different frequency bands. By accounting for the contributions of different sources to the power of the recorded signals and using a hemispheric baseline approach and a convex spectral clustering framework, the method permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410446 |
| ART UNIT | 3798 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/372 (20210101) Original (OR) Class A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178591 | Mahon et al. |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bradford Mahon (Pittsburgh, Pennsylvania); Adnan Hirad (Rochester, New York) |
| ABSTRACT | A system is configured for receiving force data including at least one value indicating the amount of the force applied to the portion of the user and at least one value indicating a direction of the force applied to the portion of the user; obtaining mapping data specifying at least one relation between values of force applied to the portion of the user and changes in a functional responsiveness, functional and/or structural integrity, or both the functional responsiveness and the functional and/or structural integrity of the brain at one or more locations in the brain; estimating, based on the mapping data and the force data, an amount of force loading at one or more particular locations in the brain; and generating, based on the estimating, output data representing an amount of the damage to the brain at the one or more particular locations in the brain. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395247 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/0053 (20130101) A61B 5/301 (20210101) A61B 5/746 (20130101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6803 (20130101) A61B 5/7264 (20130101) A61B 5/7275 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178595 | Mannoh et al. |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Emmanuel A. Mannoh (Nashville, Tennessee); Anita Mahadevan-Jansen (Nashville, Tennessee) |
| ABSTRACT | One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time. |
| FILED | Monday, October 09, 2023 |
| APPL NO | 18/377867 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 5/0075 (20130101) A61B 5/0086 (20130101) A61B 5/415 (20130101) Original (OR) Class A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/4227 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/6456 (20130101) G01N 2021/6439 (20130101) G01N 2201/0221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178601 | Kayyali et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cleveland Medical Devices Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | Cleveland Medical Devices Inc (Cleveland, Ohio) |
| INVENTOR(S) | Hani Kayyali (Shaker Heights, Ohio); Craig A. Frederick (Solon, Ohio); Christian Martin (Eden, North Carolina); Robert N. Schmidt (Ft. Myers, Florida); Brian Kolkowski (Leroy, Ohio) |
| ABSTRACT | The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep. |
| FILED | Monday, December 18, 2023 |
| APPL NO | 18/543031 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/024 (20130101) A61B 5/0077 (20130101) A61B 5/085 (20130101) A61B 5/087 (20130101) A61B 5/0205 (20130101) A61B 5/369 (20210101) A61B 5/398 (20210101) A61B 5/1114 (20130101) A61B 5/1135 (20130101) A61B 5/4812 (20130101) A61B 5/4815 (20130101) Original (OR) Class A61B 5/4818 (20130101) A61B 5/6801 (20130101) A61B 5/6814 (20130101) A61B 5/6828 (20130101) A61B 5/7264 (20130101) A61B 2505/07 (20130101) A61B 2560/0242 (20130101) A61B 2560/0431 (20130101) A61B 2562/0219 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178626 | Yeh et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Benjamin M. Yeh (Hillsborough, California); Yanjun Fu (San Francisco, California) |
| ABSTRACT | The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the encapsulated gas or partial vacuum particle contrast material into the bowel lumen with or without the deliver of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473590 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/03 (20130101) A61B 6/032 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/484 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/50 (20130101) A61K 49/0419 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178764 | Aceros et al. |
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| APPLICANT(S) | Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia) |
| ASSIGNEE(S) | University of North Florida Board of Trustees (Jacksonville, Florida) |
| INVENTOR(S) | Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia) |
| ABSTRACT | A modular ride-on is provided that is adjustable based on the needs of the operator. The modular ride-on offers children and young adults with disabilities a higher degree of freedom and comfort over traditional mobility devices—such as wheelchairs. The modular ride-on includes a chassis configured to removably couple a plurality of adjustable modules. The independently adjustable modules include a front-end module, first and second drive modules, a seating module, a harness module, an armrest module, a footrest module, a leg support module, a body module, and a control module. |
| FILED | Friday, September 22, 2023 |
| APPL NO | 18/472622 |
| ART UNIT | 3613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/10 (20130101) A61G 5/041 (20130101) Original (OR) Class A61G 5/1056 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) A61M 16/1005 (20140204) A61M 2209/082 (20130101) Vehicle Connections B60D 1/01 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/60 (20190201) B60L 2200/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178825 | Tonks et al. |
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| APPLICANT(S) | COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York); DEPYMED, INC. (Farmingdalge, New York) |
| ASSIGNEE(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Depymed, Inc. (Farmingdale, New York) |
| INVENTOR(S) | Nicholas Tonks (Cold Spring Harbor, New York); Navasona Krishnan (Hawthorn Woods, Illinois); Andreas Grill (Farmingdale, New York); Howard Sard (Woburn, Massachusetts) |
| ABSTRACT | Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I. |
| FILED | Monday, July 18, 2022 |
| APPL NO | 17/866724 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) Original (OR) Class A61K 31/4184 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178830 | Scheinberg et al. |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Thomas J. Gardner (New York, New York); Derek S. Tan (New York, New York); Jonghan Lee (New York, New York) |
| ABSTRACT | Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme. |
| FILED | Monday, July 02, 2018 |
| APPL NO | 16/627266 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 235/34 (20130101) Heterocyclic Compounds C07D 239/94 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/16 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) C12N 9/485 (20130101) Enzymes C12Y 304/17011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
12178831 — Techniques for generating cell-based therapeutics using recombinant T cell receptor genes
| US 12178831 | Dekosky et al. |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| INVENTOR(S) | Brandon Dekosky (Lawrence, Kansas); Cheng-Yu Chung (Lawrence, Kansas) |
| ABSTRACT | The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of the present technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection. |
| FILED | Wednesday, February 27, 2019 |
| APPL NO | 16/976983 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178834 | Goldman et al. |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Steven Goldman (Webster, New York); Fraser J. Sim (Buffalo, New York) |
| ABSTRACT | The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells. |
| FILED | Monday, May 09, 2022 |
| APPL NO | 17/740126 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/30 (20130101) Original (OR) Class Peptides C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) C12N 5/0623 (20130101) C12N 9/1276 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178846 | Bloomfield |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Stewart Bloomfield (New York, New York) |
| ABSTRACT | The disclosure provides methods of treating a condition of the retina by administering an inhibitor of connexin 36 and/or an inhibitor of connexin 45 to a subject with a retinal condition. This disclosure further provides compositions for the treatment of a retinal condition which include an inhibitor of connexin 36 and/or an inhibitor of connexin 45. |
| FILED | Monday, August 28, 2017 |
| APPL NO | 15/687719 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/19 (20130101) A61K 31/19 (20130101) A61K 31/196 (20130101) A61K 31/196 (20130101) A61K 31/7105 (20130101) A61K 38/16 (20130101) A61K 38/177 (20130101) Original (OR) Class A61K 38/177 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178848 | Mangelsdorf et al. |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | David J. Mangelsdorf (Dallas, Texas); Steven A. Kliewer (Dallas, Texas); Katie C. Coate (Pelham, Alabama); Genaro Hernandez (Dallas, Texas) |
| ABSTRACT | The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693057 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 38/1825 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/18 (20180101) Peptides C07K 14/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178854 | Zhang et al. |
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| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Yi Zhang (Boston, Massachusetts); Azusa Inoue (Boston, Massachusetts) |
| ABSTRACT | The invention provides methods for activating a repressed allele within an imprinting control region, thereby treating an imprinting associated disorder. |
| FILED | Thursday, July 19, 2018 |
| APPL NO | 16/631762 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/706 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) A61K 31/5375 (20130101) A61K 38/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178856 | Childers et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina); Genethon (Evry, France); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Wake Forest University Health Sciences Genethon (Evry, France); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Martin K. Childers (Seattle, Washington); Alan H. Beggs (Needham, Massachusetts); Ana Maria Buj Bello (Paris, France) |
| ABSTRACT | The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 16/935437 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class A61K 48/005 (20130101) A61K 48/0058 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/16 (20130101) C12N 2750/14143 (20130101) Enzymes C12Y 301/03 (20130101) C12Y 301/03064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178868 | Croyle et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Maria A. Croyle (Austin, Texas); Stephen Clay Schafer (Austin, Texas) |
| ABSTRACT | Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided. |
| FILED | Wednesday, September 27, 2023 |
| APPL NO | 18/476042 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/543 (20130101) A61K 2039/55555 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/88 (20130101) C12N 2710/10343 (20130101) C12N 2710/10351 (20130101) C12N 2710/10371 (20130101) C12N 2760/14134 (20130101) C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178886 | Achilefu et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/449766 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178887 | Yazaki et al. |
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| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Paul Yazaki (Duarte, California); Jack Shively (Duarte, California); Michael Bouvet (La Jolla, California); Jonathan Delong (La Jolla, California); Yuman Fong (Duarte, California) |
| ABSTRACT | Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate. |
| FILED | Thursday, January 26, 2023 |
| APPL NO | 18/160202 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) A61B 6/037 (20130101) A61B 6/4057 (20130101) A61B 34/20 (20160201) A61B 2034/2055 (20160201) A61B 2505/05 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0032 (20130101) A61K 49/0058 (20130101) Original (OR) Class A61K 51/1048 (20130101) A61K 51/1057 (20130101) A61K 51/1063 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/3007 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178902 | Hong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Young-Kwon Hong (Los Angeles, California); Dong-Won Choi (Los Angeles, California) |
| ABSTRACT | A method of treating impaired lymphatic function in a subject is provided. The method includes a step of inducing activation of Piezo1 ion channels in lymphatic tissues of a subject having impaired lymphatic function. Similarly, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg. Finally, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/146935 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/0048 (20130101) A61K 31/497 (20130101) A61K 41/0047 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178907 | Puri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anu Puri (Frederick, Maryland); Mathias Viard (Frederick, Maryland) |
| ABSTRACT | Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259499 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 41/0071 (20130101) A61K 47/60 (20170801) A61K 47/543 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178920 | Popov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); James Bourassa (Somerville, Massachusetts); Colin R. Gardner (Concord, Massachusetts); Hongming Chen (Belmont, Massachusetts); Laura M. Ensign (Towson, Maryland); Samuel K. Lai (Carrboro, North Carolina); Tao Yu (Baltimore, Maryland); Justin Hanes (Baltimore, Maryland); Ming Yang (Towson, Maryland) |
| ABSTRACT | Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. |
| FILED | Tuesday, December 05, 2023 |
| APPL NO | 18/529962 |
| ART UNIT | 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/5031 (20130101) Original (OR) Class A61K 9/5089 (20130101) A61K 9/5138 (20130101) A61K 31/12 (20130101) A61K 31/56 (20130101) A61K 31/58 (20130101) A61K 31/341 (20130101) A61K 31/405 (20130101) A61K 31/409 (20130101) A61K 31/496 (20130101) A61K 31/522 (20130101) A61K 31/569 (20130101) A61K 31/573 (20130101) A61K 31/635 (20130101) A61K 31/662 (20130101) A61K 31/675 (20130101) A61K 47/34 (20130101) A61K 49/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178940 | Gurtner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (, None) |
| INVENTOR(S) | Geoffrey C. Gurtner (Portola Valley, California); Sun Hyung Kwon (Stanford, California); Mohammed Inayathullah Nazir Ahmed (Santa Clara, California); Jayakumar Rajadas (Cupertino, California) |
| ABSTRACT | The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/049359 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2300/204 (20130101) A61L 2430/18 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178943 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (, None) |
| INVENTOR(S) | Meng Deng (West Lafayette, Indiana); Naagarajan Narayanan (Boulder, Colorado); Shihuan Kuang (West Lafayette, Indiana) |
| ABSTRACT | A composition for regeneration of skeletal muscle includes a nerve cell secretome or an isolate thereof. An implantable therapeutic material for regeneration of skeletal muscle includes a hydrogel and nerve cells encapsulated within the hydrogel, wherein at least some of the nerve cells are living. A method of regenerating skeletal muscle includes applying the composition or implanting the implantable material adjacent to skeletal muscle myoblasts and/or myogenic cells to regenerate skeletal muscle therefrom. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184231 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/145 (20130101) Original (OR) Class Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178946 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Zhongjun Wu (Marriottsville, Maryland); Bartley P. Griffith (Gibson Island, Maryland) |
| ABSTRACT | A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380319 |
| ART UNIT | 3781 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1629 (20140204) A61M 1/1698 (20130101) Original (OR) Class A61M 1/3623 (20220501) A61M 60/38 (20210101) A61M 60/113 (20210101) A61M 60/232 (20210101) A61M 2202/0208 (20130101) A61M 2205/366 (20130101) A61M 2205/3334 (20130101) A61M 2205/3368 (20130101) A61M 2206/10 (20130101) A61M 2206/16 (20130101) A61M 2209/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179026 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Jacob Robinson (Houston, Texas); Fatima Alrashdan (Houston, Texas); Kaiyuan Yang (Houston, Texas); Zhanghao Yu (Houston, Texas); Joshua Woods (Houston, Texas); Amanda Singer (Houston, Texas); Matthew Parker (Houston, Texas) |
| ABSTRACT | Exemplary embodiments of this disclosure include apparatus, systems and methods utilizing a passive, power-efficient backscattering communication system that enables transmitting data wirelessly between implantable magnetoelectric (ME) devices and an external base station. Certain embodiments encode the transmitted data through modulating the resonance frequency of a ME film by digitally tuning its electric loading conditions. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336787 |
| ART UNIT | 3796 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3727 (20130101) A61N 1/3787 (20130101) A61N 1/36062 (20170801) A61N 1/37223 (20130101) Original (OR) Class A61N 1/37288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179041 | Bader et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (, None) |
| INVENTOR(S) | Kenneth B. Bader (Chicago, Illinois); Viktor Bollen (Chicago, Illinois) |
| ABSTRACT | This disclosure describes devices, systems, and methods related to therapeutic ultrasound. An exemplary system includes a transducer configured to emit therapy ultrasound waves towards a therapy site and an ultrasound imaging device configured to emit plane wave ultrasound waves towards the therapy site. The system further includes a controller coupled to the transducer and the ultrasound imaging device. The controller is configured to send an activation signal to the transducer and send an activation signal to the ultrasound imaging device. The controller is further configured to receive image data from the ultrasound imaging device and generate bubble cloud image data based on the received image data. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 16/809732 |
| ART UNIT | 3798 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/14 (20130101) A61B 8/0833 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) Original (OR) Class A61N 2007/0004 (20130101) A61N 2007/0039 (20130101) A61N 2007/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180156 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhttan, Kansas); Wichita State University (Wichita, Kansas); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | Kansas State University Research Foundation (Manhattan, Kansas); Wichita State University (Wichita, Kansas); University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Kyeong-Ok Chang (Manhttan, Kansas); Yunjeong Kim (Manhattan, Kansas); William C. Groutas (Wichita, Kansas); Stanley Perlman (Iowa City, Iowa) |
| ABSTRACT | Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: or a prodrug or pharmaceutically-acceptable salt thereof, where: each X comprises at least one cyclic moiety directly attached to the oxygen or connected via an alkyl linkage, where at least one of the linkage and/or the X moiety comprises a deuterium substitution; and Z is selected from the group consisting of aldehydes and bisulfite salts, or the ester or carbamate prodrugs thereof. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343334 |
| ART UNIT | 1699 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 207/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180159 | Shapiro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | David J. Shapiro (Urbana, Illinois); Paul J. Hergenrother (Champaign, Illinois); Matthew W. Boudreau (Urbana, Illinois) |
| ABSTRACT | A set of small molecules ERα biomodulators that kill therapy-resistant ERα positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant/ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later. |
| FILED | Monday, July 01, 2019 |
| APPL NO | 17/254771 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180165 | David et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| INVENTOR(S) | Sunil A. David (Lawrence, Kansas); Mallesh Beesu (Lawrence, Kansas); Giuseppe Caruso (Lawrence, Kansas); Alex Salyer (Marion, Ohio) |
| ABSTRACT | The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472371 |
| ART UNIT | 1621 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Heterocyclic Compounds C07D 215/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180182 | Dai |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Mingji Dai (Alpharetta, Georgia) |
| ABSTRACT | One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby. |
| FILED | Thursday, December 01, 2022 |
| APPL NO | 18/060922 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 229/34 (20130101) Heterocyclic Compounds C07D 209/50 (20130101) C07D 211/14 (20130101) C07D 211/62 (20130101) C07D 263/56 (20130101) C07D 295/145 (20130101) C07D 311/16 (20130101) C07D 333/34 (20130101) C07D 401/06 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 403/06 (20130101) C07D 405/14 (20130101) C07D 409/12 (20130101) C07D 409/14 (20130101) C07D 413/14 (20130101) C07D 491/107 (20130101) Steroids C07J 43/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180198 | Hergenrother et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. Hergenrother (Champaign, Illinois); Emily Jane Geddes (Urbana, Illinois); Bryon Shane Drown (Champaign, Illinois); Stephen E. Motika (Urbana, Illinois); Erica Nicole Parker (Urbana, Illinois) |
| ABSTRACT | Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria. |
| FILED | Thursday, June 29, 2023 |
| APPL NO | 18/344336 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 409/14 (20130101) Original (OR) Class C07D 471/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180216 | Cook et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); Centre for Addiction and Mental Health (Toronto, Canada); University of Belgrade Faculty of Pharmacy (Belgrade, Serbia) |
| ASSIGNEE(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| INVENTOR(S) | James M. Cook (Milwaukee, Wisconsin); Guanguan Li (Milwaukee, Wisconsin); Michael Ming-Jin Poe (Kalamazoo, Michigan); Miroslav M. Savic (Belgrade, Serbia); Etienne Sibille (Toronto, Canada) |
| ABSTRACT | Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them. |
| FILED | Wednesday, August 02, 2023 |
| APPL NO | 18/363933 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/22 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180220 | Ungashe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tosk, Inc. (Mountain View, California) |
| ASSIGNEE(S) | Tosk, Inc. (Mountain View, California) |
| INVENTOR(S) | Solomon B. Ungashe (Mountain View, California); Stephen D. Yanofsky (Mountain View, California) |
| ABSTRACT | RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484739 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 239/84 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/10 (20130101) C07D 405/14 (20130101) C07D 471/04 (20130101) C07D 491/056 (20130101) Original (OR) Class C07D 519/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180228 | Movassaghi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mohammad Movassaghi (Lincoln, Massachusetts); Chase Robert Olsson (La Jolla, California); Tony Z. Scott (Cambridge, Massachusetts); Jaime Cheah (Medford, Massachusetts); Joshua Nathaniel Payette (Hollis, New Hampshire) |
| ABSTRACT | The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines. |
| FILED | Friday, December 23, 2022 |
| APPL NO | 18/146294 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180246 | Choe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Boyce Thompson Institute for Plant Research (Ithaca, New York) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); Boyce Thompson Institute for Plant Research (Ithaca, New York) |
| INVENTOR(S) | Andrea Choe (Pasadena, California); Paul W. Sternberg (San Marino, California); Frank C. Schroeder (Ithaca, New York); Stephan H. Von Reuss (Jena, Germany) |
| ABSTRACT | The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside. |
| FILED | Monday, June 12, 2023 |
| APPL NO | 18/208629 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/36 (20130101) A01N 43/16 (20130101) A01N 43/38 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/7028 (20130101) Heterocyclic Compounds C07D 309/10 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) Original (OR) Class C07H 15/08 (20130101) C07H 15/10 (20130101) C07H 15/18 (20130101) C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180251 | Pan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Hui-Lin Pan (Houston, Texas) |
| ABSTRACT | The present disclosure provides α2δ-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an α2δ-1 C-terminal domain peptide which blocks binding of α2δ-1 to the glutamate receptors NMDAR and AMPAR. |
| FILED | Monday, September 11, 2023 |
| APPL NO | 18/465145 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/485 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 23/00 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/00 (20130101) Original (OR) Class C07K 14/005 (20130101) C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1138 (20130101) C12N 2740/15043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180254 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Wenchao Song (Bryn Mawr, Pennsylvania); Damodar Gullipalli (Philadelphia, Pennsylvania); Takashi Miwa (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Disclosed herein are factor H variants, vectors comprising said factor H variants, and pharmaceutical compositions comprising the same for treatment of disorders. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/494883 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180263 | Cowan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Chad A. Cowan (Boston, Massachusetts); Leonardo M. R. Ferreira (Cambridge, Massachusetts); Torsten B. Meissner (Somerville, Massachusetts); Jack L Strominger (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are cells and populations of cells comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I protein in the cells or population of cells, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells. |
| FILED | Friday, November 06, 2015 |
| APPL NO | 15/524968 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/28 (20130101) A61K 48/0066 (20130101) A61K 2035/124 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/70539 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1138 (20130101) C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180267 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Patrick Wilson (Chicago, Illinois); Yaoqing Chen (Chicago, Illinois); Haley L. Dugan (Chicago, Illinois) |
| ABSTRACT | Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith. |
| FILED | Thursday, June 15, 2023 |
| APPL NO | 18/335874 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180269 | Pasqualini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R. M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837943 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 47/6891 (20170801) A61K 47/68031 (20230801) A61K 47/68033 (20230801) A61K 49/0008 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/1037 (20130101) C12N 2810/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180296 | Ho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Mitchell Ho (Urbana, Maryland); Ira H. Pastan (Potomac, Maryland); Jessica D. Hong (Herndon, Virginia); Nan Li (Laurel, Maryland) |
| ABSTRACT | Camel single-domain monoclonal antibodies that specifically bind human and mouse mesothelin are described. Chimeric antigen receptor (CAR) T cells and antibody conjugates based on the mesothelin-specific antibodies are also described. The disclosed CAR T cells, mesothelin-specific antibodies and conjugates thereof can be used, for example, in the diagnosis or treatment of mesothelin-positive cancers. |
| FILED | Thursday, January 02, 2020 |
| APPL NO | 17/421334 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464468 (20230501) A61K 47/6851 (20170801) A61K 47/6929 (20170801) A61K 2039/505 (20130101) A61K 2239/31 (20230501) A61K 2239/38 (20230501) A61K 2239/55 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) C07K 14/7153 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2809 (20130101) C07K 2317/22 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180301 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IMCARE BIOTECH, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | ImCare Biotech, LLC (Doylestown, Pennsylvania) |
| INVENTOR(S) | Xuanyong Lu (Horsham, Pennsylvania); Felix Lu (Woodland Hills, California) |
| ABSTRACT | Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/978634 |
| ART UNIT | 1677 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 16/38 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/57438 (20130101) G01N 2800/50 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180350 | Salaita et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Khalid Salaita (Atlanta, Georgia); Yixiao Dong (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to non-naturally occurring light reflecting or color changing materials comprising a segmented array of flexible polymers, wherein the segmented array of flexible polymers comprise photonic crystal lattices embedded therein, wherein the segmented array of flexible polymers are themselves embedded within an elastic supporting polymer that maintains a near constant size during chromatic shifting of the photonic crystal lattices. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397318 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Original (OR) Class C08K 3/36 (20130101) C08K 7/24 (20130101) C08K 9/02 (20130101) C08K 2003/2275 (20130101) C08K 2201/011 (20130101) Compositions of Macromolecular Compounds C08L 33/26 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180446 | Huh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Dongeun Huh (Villanova, Pennsylvania); Mark Mondrinos (Philadelphia, Pennsylvania); Alex Yoon Yi (Philadelphia, Pennsylvania); Jeongyun Seo (Philadelphia, Pennsylvania) |
| ABSTRACT | The presently disclosed subject matter provides native extracellular matrix-derived membrane inserts for organs-on-chips, multilayer microfluidics microdevices, bioreactors, tissue culture inserts, and two-dimensional and three-dimensional cell culture systems. A microfluidic cell culture is provided that can include at least one membrane including extracellular matrix (ECM) material. The ECM material can be used to construct a perfusable microfluidic system including a plurality of layers of microfabricated cell culture chambers. The microfluidic cell culture can further include a lower layer including a microchannel on which the at least one membrane is placed and an upper layer including another microchannel. The upper layer can be bonded to the lower layer. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 16/787275 |
| ART UNIT | 1799 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 23/22 (20130101) C12M 23/34 (20130101) C12M 29/04 (20130101) C12M 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180447 | Chou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David Benson Chou (Boston, Massachusetts); Liliana S. Teixeira Moreira Leijten (Maastricht, Netherlands); Arianna Rech (Leicestershire, United Kingdom); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Yuka Milton (Cambridge, Massachusetts); Viktoras Frismantas (Roxburg Crossing, Massachusetts); Oren Levy (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343514 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/12 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2501/40 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180449 | Everingham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | Boise State University (Boise, Idaho) |
| INVENTOR(S) | John Everingham (Boise, Idaho); Trevor Lujan (Boise, Idaho) |
| ABSTRACT | A mold capable of preparing a cellular or acellular construct includes a block including a three-dimensional cavity for a sample, a base, and a removable sheet inserted between the block and the base. The sheet may be coated with silicone grease prior to insertion of the sheet between the block and the base. Mechanical constraints may be included at each end of the cavity to constrain cell driven contraction and to allow for gripping the sample after the sample is removed from the mold. The sample may be prepared by partially filling the cavity with gel, filling the remaining portion of the cavity with culture media, and allowing a three-dimensional sample to culture within the cavity for a time. The sample may be transported to a bioreactor and ejected from the mold by removing the sheet and applying pressure to the mechanical constraints. |
| FILED | Monday, February 25, 2019 |
| APPL NO | 16/284449 |
| ART UNIT | 1796 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/505 (20130101) B01L 3/502707 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2527/00 (20130101) C12N 2533/40 (20130101) C12N 2535/00 (20130101) C12N 2539/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180473 | Yen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Laising Yen (Houston, Texas); Sachin Kumar Gupta (Houston, Texas); Jocelyn Duen-Ya Jea (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions in which two inter-chromosomal or intra-chromosomal genomic DNA regions are rearranged upon exposure of the genomic DNA to a chimeric RNA that produces fusion of the two regions. The chimeric RNA hybridizes to the two different parts of the genomic DNA and forms a DNA/RNA hybrid in a sequence-specific manner, thereby facilitating genomic rearrangement. In particular embodiments this mechanism is utilized to produce directed gene fusion in targeted genomic DNA regions. |
| FILED | Tuesday, April 16, 2019 |
| APPL NO | 17/047924 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180474 | Monga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Satdarshan Monga (Wexford, Pennsylvania); Kari Nejak-Bowen (Wexford, Pennsylvania) |
| ABSTRACT | A method of treating porphyria in a patient is provided comprising knocking down or reducing expression or activity of β-catenin in the patient. e.g., in the liver of a patient, to an extent effective to treat porphyria in a patient. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/194706 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180477 | Khvorova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | UNIVERSITY OF MASSACHUSETTS (Westborough, Massachusetts) |
| INVENTOR(S) | Anastasia Khvorova (Westborough, Massachusetts); Bruno Miguel da Cruz Godinho (Worcester, Massachusetts); Matthew Hassler (Worcester, Massachusetts) |
| ABSTRACT | Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725102 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) C12N 2310/3513 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180484 | Kochenderfer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745067 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180486 | Mitra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robi D. Mitra (St. Louis, Missouri); Arnav Moudgil (St. Louis, Missouri); Michael Nathaniel Wilkinson (St. Louis, Missouri); Zongtai Qi (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Robi D. Mitra (St. Louis, Missouri); Arnav Moudgil (St. Louis, Missouri); Michael Nathaniel Wilkinson (St. Louis, Missouri); Zongtai Qi (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions and methods for mapping transposon insertions. Applications can include mapping the locations of self-reporting transposons (SRTs) from thousands of single cells in parallel, while simultaneously measuring mRNA abundance from the same single cells; analyzing genome-associated protein (GAP) (e.g., transcription factor) binding/interactions in a small number of cells in bulk, without single cell resolution; lineage tracing; or as an improved readout for transposon mutagenesis screens. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/711011 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/11 (20130101) C12N 2310/20 (20170501) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180487 | Johnston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Center (Seattle, Washington) |
| INVENTOR(S) | Christopher Johnston (Seattle, Washington); Sean Cotton (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments include engineered minicircle-producing bacterium with differential methylation capability, as well as kits and compositions comprising the bacterium. Further described are methods of using of the bacterium for producing differentially methylated minicircle DNA, and for improving transformation efficiency of exogenous DNA in intractable bacteria. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428585 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/1007 (20130101) C12N 15/70 (20130101) Original (OR) Class C12N 15/74 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180499 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| INVENTOR(S) | Eric Tzy-Shi Wang (Gainesville, Florida); Tanvi Saxena (Gainesville, Florida); Belinda Pinto (Gainesville, Florida); John Andrew Berglund (Gainesville, Florida) |
| ABSTRACT | Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats. |
| FILED | Tuesday, October 31, 2017 |
| APPL NO | 16/346163 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 38/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14123 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180507 | Khetani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (, None) |
| INVENTOR(S) | Salman R. Khetani (Chicago, Illinois); Mitchell J. Durham (Fort Collins, Colorado); Brenton R. Ware (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs. |
| FILED | Friday, August 05, 2016 |
| APPL NO | 15/749733 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/44 (20130101) A61K 35/407 (20130101) A61K 35/407 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2502/1323 (20130101) C12N 2503/02 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) C12N 2535/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180516 | Bowie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | James U. Bowie (Los Angeles, California); Meaghan Valliere (Leominster, Massachusetts); Tyler P. Korman (Sierra Madre, California); Nicholas Woodall (Knoxville, Tennessee) |
| ABSTRACT | Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049221 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) C12P 7/42 (20130101) C12P 9/00 (20130101) C12P 17/06 (20130101) Enzymes C12Y 102/03003 (20130101) C12Y 205/01039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180520 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Medford, Massachusetts) |
| ABSTRACT | Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010107 |
| ART UNIT | 1699 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/40 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 301/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180524 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); INSTITUTO POLITÉCNICO NACIONAL (Mexico City, Mexico); KING ABDULAZIZ UNIVERSITY (Jeddah, Saudi Arabia) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); INSTITUTO POLITÉCNICO NACIONAL (Mexico City, Mexico); KING ABDULAZIZ UNIVERSITY (Jeddah, Saudi Arabia) |
| INVENTOR(S) | Bill J. Baker (Temple Terrace, Florida); Dennis E. Kyle (Athens, Georgia); Mario Alberto Rodriguez-Pérez (Reynosa, Mexico); Anne-Claire D. Limon (Tampa, Florida); Ala Azhari (Tampa, Florida) |
| ABSTRACT | Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/406025 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/181 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180534 | Xuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Xuan (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Mingjie Dai (Cambridge, Massachusetts); Xi Chen (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523611 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 2525/186 (20130101) C12Q 2525/301 (20130101) C12Q 2531/119 (20130101) C12Q 2565/514 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 70/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180536 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536766 |
| ART UNIT | 1684 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6855 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180544 | Ju et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingyue Ju (Englewood Cliffs, New Jersey); Huanyan Cao (Changzhou, China PRC); Zengmin Li (Flushing, New York); Qinglin Meng (Foster City, California); Jia Guo (Chandler, Arizona); Shenglong Zhang (Fort Lee, New Jersey); Lin Yu (New York, New York) |
| ABSTRACT | This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560928 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/06 (20130101) C07H 19/10 (20130101) C07H 19/14 (20130101) C07H 19/16 (20130101) C07H 19/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2525/301 (20130101) C12Q 2525/301 (20130101) C12Q 2537/157 (20130101) C12Q 2537/157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181386 | Jenkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio); University Hospitals Cleveland Medical Center (Cleveland, Ohio) |
| ASSIGNEE(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER (Cleveland, Ohio); VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | Michael W. Jenkins (Cleveland, Ohio); Yehe Liu (Cleveland, Ohio) |
| ABSTRACT | The present disclosure relates to an optical clearing method called lipid-preserving index matching for prolonged imaging depth (LIMPID). The optical clearing method can include simply immersing a sample in an optical clearing solution before imaging (e.g., with microscopy or optical coherence tomography). The optical clearing solution can include water; an iodine-containing non-ionic radiocontrast agent; and urea. |
| FILED | Friday, November 09, 2018 |
| APPL NO | 16/760652 |
| ART UNIT | 1678 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181393 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jongyoon Han (Bedford, Massachusetts); Hyuckjin Kwon (Somerville, Massachusetts) |
| ABSTRACT | The invention is directed to a scalable concentration device and method of use thereof based on electrokinetics. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/191842 |
| ART UNIT | 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 57/02 (20130101) B01D 61/027 (20130101) B01D 61/485 (20130101) B01D 2325/0282 (20220801) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) Original (OR) Class G01N 33/48707 (20130101) G01N 2001/4038 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181467 | Sista et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Liquid Logic, Inc. (San Diego, California); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | ADVANCED LIQUID LOGIC, INC. (San Diego, California); DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Ramakrishna Sista (Cary, North Carolina); Vamsee K. Pamula (Cary, North Carolina); Michael G. Pollack (Durham, North Carolina); Vijay Srinivasan (Cary, North Carolina); Allen E. Eckhardt (San Diego, California); Richard B. Fair (Durham, North Carolina) |
| ABSTRACT | A method comprising effecting a change in a shape of a droplet, wherein the droplet is disposed over a substrate in sensing proximity to a sensor and the droplet has a starting surface area exposed to the sensor; and producing an expanded surface area of the droplet in the sensing proximity exposed to the sensor, wherein the expanded surface area exposed to the sensor is greater than the starting surface area exposed to the sensor. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 16/455506 |
| ART UNIT | 1758 — Printing/Measuring and Testing |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 2200/025 (20130101) B01L 2200/028 (20130101) B01L 2200/141 (20130101) B01L 2200/0647 (20130101) B01L 2200/0673 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/043 (20130101) B01L 2400/0427 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/01 (20130101) C12M 25/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44717 (20130101) G01N 27/44786 (20130101) G01N 33/54326 (20130101) Original (OR) Class G01N 33/54386 (20130101) G01N 35/0098 (20130101) G01N 2035/1046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181481 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | AmberGen, Inc. (Billerica, Massachusetts) |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399417 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181482 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AMBERGEN, Inc. (Billerica, Massachusetts) |
| ASSIGNEE(S) | AmberGen, Inc. (Billerica, Massachusetts) |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. The field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout, and also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI. |
| FILED | Wednesday, June 21, 2023 |
| APPL NO | 18/212456 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181544 | Alipour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Akbar Alipour (New York, New York); Priti Balchandani (New York, New York); Alan C. Seifert (New York, New York) |
| ABSTRACT | A radiofrequency (RF) resonator array device for use in magnetic resonance imaging (MRT), The RF resonator array device includes a substrate. An array of coupled split ring resonators are located on the substrate. Each of the coupled split ring resonators includes a first split ring resonator positioned on a first side of the substrate and a second split ring resonator positioned on a second side of the substrate located opposite the first side. The second split ring resonator is inductively coupled to the first split ring resonator. Methods of making and using the RF resonator device are also disclosed. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/922912 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/343 (20130101) Original (OR) Class G01R 33/3642 (20130101) G01R 33/34076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181554 | Nezafat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Reza Nezafat (Newton, Massachusetts); Rui Guo (Jamaica Plain, Massachusetts) |
| ABSTRACT | A system for quantitative parameter mapping using magnetic resonance (MR) image includes an input for receiving a plurality of weighted MR images of a subject and a corresponding at least one imaging parameter for the plurality of weighted MR images, and a quantitative parameter mapping neural network coupled to the input and configured to estimate at least one tissue parameter and generate at least one quantitative map for the at least one tissue parameter based on the plurality of weighted MR images of the subject and the corresponding at least one imaging parameter. The quantitative parameter mapping neural network can be trained using a set of training data utilizing at least one confounder for the quantification of the at least one tissue parameter. The system can further include a display coupled to the quantitative parameter mapping neural network to display the at least one quantitative map. |
| FILED | Friday, December 16, 2022 |
| APPL NO | 18/067489 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/5608 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0455 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12182331 | Aceros et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia) |
| ASSIGNEE(S) | University of North Florida Board of Trustees (Jacksonville, Florida) |
| INVENTOR(S) | Juan Aceros (St. Johns, Florida); Matthew Cantwell (Orange Park, Florida); John Prisco (Holly Springs, Georgia) |
| ABSTRACT | Described herein relates to an apparatus and method for developmental and/or rehabilitative sensory substitution to augment at least one low-functioning and/or non-functioning senses in at least one user. The apparatus may include an input module that may allow the user to perform various tasks designed to enhance development of or sensory recognition by the user. The apparatus may be capable of multiple different proportional controls and of being used across ages, sizes, and developmental stages. For example, the apparatus may include at least one joystick, button, lever, and accelerometer, such that a sensory feedback response (e.g., haptic/tactile, visual, and/or auditory) may be provided to the user across a plurality of exercises. Additionally, the apparatus may provide a new standard of care for individuals with special needs and/or those recovering from a traumatic physical and/or mental injury, regardless of ability level and age. |
| FILED | Tuesday, September 26, 2023 |
| APPL NO | 18/474537 |
| ART UNIT | 2627 — Selective Visual Display Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183467 | Baronov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etiometry Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Etiometry Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Dimitar V. Baronov (Weston, Massachusetts); Evan J. Butler (New Haven, Connecticut); Jesse M. Lock (Winchester, Massachusetts); Michael F. McManus (Pembroke, Massachusetts) |
| ABSTRACT | A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient. |
| FILED | Tuesday, May 17, 2022 |
| APPL NO | 17/745969 |
| ART UNIT | 3686 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) Original (OR) Class G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183566 | Jarrold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Indiana); Daniel Botamanenko (Bloomington, Indiana) |
| ABSTRACT | A charge detection mass spectrometer (CDMS) includes an electrostatic linear ion trap (ELIT), a processor, and a memory having instructions stored therein executable by the processor to (a) control the ELIT to trap an ion, (b) collect ion measurement information as the trapped ion oscillates back and forth through the ELIT, the ion measurement information including charge induced by the ion on a charge detector of the ELIT during each pass of the ion through the ELIT and timing of the induced charges relative to one another, (c) process the ion measurement information in the time-domain for each of a plurality of sequential time windows of the ion measurement information to determine a charge magnitude of the ion during each time window, and (d) determine the magnitude of charge of the trapped ion based on the charge magnitudes of each of the time windows. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/791979 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) H01J 49/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 12178907 | Puri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anu Puri (Frederick, Maryland); Mathias Viard (Frederick, Maryland) |
| ABSTRACT | Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259499 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 41/0071 (20130101) A61K 47/60 (20170801) A61K 47/543 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178940 | Gurtner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (, None) |
| INVENTOR(S) | Geoffrey C. Gurtner (Portola Valley, California); Sun Hyung Kwon (Stanford, California); Mohammed Inayathullah Nazir Ahmed (Santa Clara, California); Jayakumar Rajadas (Cupertino, California) |
| ABSTRACT | The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/049359 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2300/204 (20130101) A61L 2430/18 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179026 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Jacob Robinson (Houston, Texas); Fatima Alrashdan (Houston, Texas); Kaiyuan Yang (Houston, Texas); Zhanghao Yu (Houston, Texas); Joshua Woods (Houston, Texas); Amanda Singer (Houston, Texas); Matthew Parker (Houston, Texas) |
| ABSTRACT | Exemplary embodiments of this disclosure include apparatus, systems and methods utilizing a passive, power-efficient backscattering communication system that enables transmitting data wirelessly between implantable magnetoelectric (ME) devices and an external base station. Certain embodiments encode the transmitted data through modulating the resonance frequency of a ME film by digitally tuning its electric loading conditions. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336787 |
| ART UNIT | 3796 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3727 (20130101) A61N 1/3787 (20130101) A61N 1/36062 (20170801) A61N 1/37223 (20130101) Original (OR) Class A61N 1/37288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179269 | Nault et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Isaac M. Nault (Bel Air, Maryland); Kenneth W. Young (Bear, Delaware); Gehn D. Ferguson (Baltimore, Maryland); Aaron T. Nardi (East Granby, Connecticut) |
| ABSTRACT | A method of determining a tool path for an additive deposition on a surface, the method including receiving primary edges data of the surface of a three-dimensional (3D) object; calculating a number of raster lines for applying an additive deposition on the surface; mapping a raster pattern to the surface of the 3D object; calculating surface normal and rotational angles along the raster lines; calculating a nozzle velocity of an additive application used for producing the additive deposition on the surface; identifying curvature effects of the 3D object; and establishing an order of performing passes of the additive deposition on the surface based on a selected direction for performing the additive deposition and a consideration of a residual stress profile of a resulting deposit. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329811 |
| ART UNIT | 2115 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) B22F 10/34 (20210101) B22F 10/38 (20210101) Original (OR) Class B22F 10/85 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) Wind Motors F03D 1/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179298 | Deluca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Arlington, Virginia) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Michael J. Deluca (Norristown, Pennsylvania); Matthew H. Cawthorne (Wayne, Pennsylvania); Howard T. Rolleston (Glen Mills, Pennsylvania) |
| ABSTRACT | A method for repairing a crack in a structure includes mounting a manifold to the structure around the crack. The structure has a nonplanar surface contour that surrounds the crack. The manifold has a base portion, a cover portion, and a plug. The base portion has a grip surface configured to conform to the nonplanar surface contour of the structure. The cover portion is connected to the base portion, and has an injection port and a vent port in fluid communication with a channel aligned to the crack. The injection port transfers a bonding material into and out of the channel. The plug closes and opens the vent port. The method includes filling the channel with the bonding material to direct the bonding material into the crack, and draining the bonding material from the manifold. |
| FILED | Tuesday, November 28, 2023 |
| APPL NO | 18/521150 |
| ART UNIT | 1746 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/002 (20130101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 6/04 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 73/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179415 | Simpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| INVENTOR(S) | Patrick Simpson (Fargo, North Dakota); Michael Holthaus (Fargo, North Dakota); Chad Ulven (Fargo, North Dakota) |
| ABSTRACT | Suspending fibers within a substantially similar direction within flow field allows for an even dispersion of fibers in a manufactured composite. The flow field can be established within a resin tank so as to control orientation of the fibers. An advantage of this approach is that fiber orientation can be changed layer by layer during printing. No matter where the reinforcements need to be, the fibers can be aligned on the fly to accommodate. 3D prints can made stronger for a very wide range of objects and opportunities. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/305224 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Original (OR) Class B29C 64/321 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179534 | Flory et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRATT and MILLER ENGINEERING and FABRICATION, LLC (New Hudson, Michigan) |
| ASSIGNEE(S) | Pratt and Miller Engineering and Fabrication, LLC (New Hudson, Michigan) |
| INVENTOR(S) | Kenneth J. Flory (West Bloomfield, Michigan); Jesper Slattengren (Ann Arbor, Michigan); Guido Francesco Ritelli (Farmington Hills, Michigan) |
| ABSTRACT | A hydraulic suspension system for a motor vehicle having at least a pair of road engaging wheels. The suspension system includes, a hydraulic cylinder coupled with the each of the pair of road engaging wheels, the hydraulic cylinder defining a cap end volume and a rod end volume separated by a piston. A hydraulic supply circuit for the hydraulic cylinder includes, a high pressure hydraulic source, a low pressure hydraulic drain, a pair of hydraulic sub circuits each coupled to one of the hydraulic cylinder cap and rod end volumes. Each hydraulic sub circuit includes, a proportional supply flow valve coupled with the high pressure hydraulic source and one of the cylinder volumes, a return flow control proportional valve coupled with the low pressure hydraulic drain and the one cylinder volume, and an accumulator coupled to the associated hydraulic cylinder volume through an accumulator fill control proportional valve. |
| FILED | Wednesday, March 29, 2023 |
| APPL NO | 18/127911 |
| ART UNIT | 3616 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Vehicle Suspension Arrangements B60G 11/265 (20130101) Original (OR) Class B60G 17/056 (20130101) B60G 2202/154 (20130101) B60G 2202/413 (20130101) B60G 2202/414 (20130101) B60G 2202/416 (20130101) B60G 2300/07 (20130101) B60G 2500/114 (20130101) B60G 2600/182 (20130101) B60G 2800/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179895 | Benson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TETAC, Inc (Monterey, California) |
| ASSIGNEE(S) | TETAC Inc. (Monterey, California) |
| INVENTOR(S) | Mark Benson (Carmel, California) |
| ABSTRACT | An underwater explosive container to house explosives and explosive tools for deployment on bottom mines, moored mines, and underwater explosive devices that can be positioned via a remotely operated vehicle or a diver for neutralizing, rendering safe, or detonating the intended target and methods of building and utilizing the underwater explosive container. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229730 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179907 | Birch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Orbital Research Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | Orbital Research Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Matthew C. Birch (Madison, Alabama); Zak Sowle (Bellbrook, Ohio) |
| ABSTRACT | Multiple redundant harmonic drive motors on a rotor head actuate the angle of attack of rotor blades at the rotor blade roots, providing collective control that, in combination with a system for providing cyclic control on the rotor blades, eliminates the need for a swashplate, thereby advantageously reducing the weight and maintenance cost of a helicopter, increasing its reliability, and reducing its vulnerability to ballistic attack. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/861698 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/06 (20130101) B64C 11/30 (20130101) Original (OR) Class B64C 27/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180159 | Shapiro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | David J. Shapiro (Urbana, Illinois); Paul J. Hergenrother (Champaign, Illinois); Matthew W. Boudreau (Urbana, Illinois) |
| ABSTRACT | A set of small molecules ERα biomodulators that kill therapy-resistant ERα positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant/ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later. |
| FILED | Monday, July 01, 2019 |
| APPL NO | 17/254771 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180296 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Mitchell Ho (Urbana, Maryland); Ira H. Pastan (Potomac, Maryland); Jessica D. Hong (Herndon, Virginia); Nan Li (Laurel, Maryland) |
| ABSTRACT | Camel single-domain monoclonal antibodies that specifically bind human and mouse mesothelin are described. Chimeric antigen receptor (CAR) T cells and antibody conjugates based on the mesothelin-specific antibodies are also described. The disclosed CAR T cells, mesothelin-specific antibodies and conjugates thereof can be used, for example, in the diagnosis or treatment of mesothelin-positive cancers. |
| FILED | Thursday, January 02, 2020 |
| APPL NO | 17/421334 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/4611 (20230501) A61K 39/4631 (20230501) A61K 39/464468 (20230501) A61K 47/6851 (20170801) A61K 47/6929 (20170801) A61K 2039/505 (20130101) A61K 2239/31 (20230501) A61K 2239/38 (20230501) A61K 2239/55 (20230501) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) C07K 14/7153 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) Original (OR) Class C07K 16/2809 (20130101) C07K 2317/22 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180324 | Wagener et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| INVENTOR(S) | Kenneth B. Wagener (Gainesville, Florida); Julia Grace Pribyl (Gainesville, Florida); Michael H. Bell (North East, Maryland) |
| ABSTRACT | A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture, heating the reaction mixture to a temperature of 100° C. or greater in the absence of a solvent in bulk conditions, and mechanically stirring the reaction mixture. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/598975 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2278 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0046 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/80 (20130101) Original (OR) Class C08F 36/14 (20130101) C08F 36/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180350 | Salaita et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Khalid Salaita (Atlanta, Georgia); Yixiao Dong (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to non-naturally occurring light reflecting or color changing materials comprising a segmented array of flexible polymers, wherein the segmented array of flexible polymers comprise photonic crystal lattices embedded therein, wherein the segmented array of flexible polymers are themselves embedded within an elastic supporting polymer that maintains a near constant size during chromatic shifting of the photonic crystal lattices. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397318 |
| ART UNIT | 1763 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Original (OR) Class C08K 3/36 (20130101) C08K 7/24 (20130101) C08K 9/02 (20130101) C08K 2003/2275 (20130101) C08K 2201/011 (20130101) Compositions of Macromolecular Compounds C08L 33/26 (20130101) Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180400 | Rand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Barry P. Rand (Princeton, New Jersey); Zhengguo Xiao (Plainsboro, New Jersey) |
| ABSTRACT | In one aspect, organic-inorganic nanoparticle compositions are described herein comprising engineered surfaces which, in some embodiments, reduce non-radiative recombination mechanisms, thereby providing optoelectronic devices with enhanced efficiencies. In some embodiments, a nanoparticle composition comprises a layer of organic-inorganic perovskite nanocrystals, the organic-inorganic perovskite nanocrystals comprising surfaces associated with growth passivation ligands and trap passivation ligands, wherein the growth passivation ligands are larger than the trap passivation ligands and are of size unable to incorporate into octahedral corner sites of the perovskite crystal structure. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/413271 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) B82Y 40/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/10 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) Organic electric solid-state devices H10K 30/10 (20230201) H10K 85/30 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180447 | Chou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David Benson Chou (Boston, Massachusetts); Liliana S. Teixeira Moreira Leijten (Maastricht, Netherlands); Arianna Rech (Leicestershire, United Kingdom); Richard Novak (Jamaica Plain, Massachusetts); Donald E. Ingber (Boston, Massachusetts); Yuka Milton (Cambridge, Massachusetts); Viktoras Frismantas (Roxburg Crossing, Massachusetts); Oren Levy (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media. |
| FILED | Wednesday, June 28, 2023 |
| APPL NO | 18/343514 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/12 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 29/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2501/40 (20130101) C12N 2501/999 (20130101) C12N 2502/28 (20130101) C12N 2533/54 (20130101) C12N 2533/56 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180484 | Kochenderfer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells. |
| FILED | Monday, May 16, 2022 |
| APPL NO | 17/745067 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/18 (20130101) C07K 16/2878 (20130101) C07K 2317/73 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180534 | Xuan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Xuan (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Mingjie Dai (Cambridge, Massachusetts); Xi Chen (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523611 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 2525/186 (20130101) C12Q 2525/301 (20130101) C12Q 2531/119 (20130101) C12Q 2565/514 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 70/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180583 | Kummel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Merck Patent GmbH (Darmstadt, Germany) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Merck Patent GmbH (Darmstadt, Germany) |
| INVENTOR(S) | Andrew Kummel (San Diego, California); Cheng-Hsuan Kuo (San Diego, California); SeongUk Yun (Carlsbad, California); Ravindra Kanjolia (North Andover, Massachusetts); Mansour Moinpour (San Jose, California); Daniel Moser (Manitowoc, Wisconsin) |
| ABSTRACT | A method of forming a conformal layer including TiN in a via includes introducing a precursor into a reaction chamber according to a first exposure schedule. The precursor includes non-halogenated metal-organic titanium. The first exposure schedule indicates precursor exposure periods. Each precursor exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the precursor during the particular duration of time. The method includes introducing a co-reactant into the reaction chamber according to a second exposure schedule. The co-reactant includes nitrogen. The second exposure schedule indicates co-reactant exposure periods. Each co-reactant exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the co-reactant during the particular duration of time. The method includes providing the conformal layer including TiN in the via based on said introducing the precursor and the co-reactant. |
| FILED | Tuesday, December 06, 2022 |
| APPL NO | 18/062274 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/34 (20130101) C23C 16/045 (20130101) Original (OR) Class C23C 16/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180887 | Mcclearn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Michael Mcclearn (Dayton, Ohio); Riley Huff (Beavercreek, Ohio); John Hoke (Xenia, Ohio); Matthew Fotia (Kettering, Ohio) |
| ABSTRACT | A rotating detonation combustor (RDC) and an associated system is disclosed herein. The RDC can be operably coupled with a vehicle to provide additional power capability over the primary motive power source. The RDC can be operated on demand to provide power to a turbine connected to an electrical power generator in some forms. The RDC can be used in stationary systems as well as moving vehicle systems. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 16/686702 |
| ART UNIT | 3799 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 5/02 (20130101) Original (OR) Class F02C 6/00 (20130101) F02C 7/32 (20130101) F02C 9/26 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/50 (20130101) F05D 2220/76 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181187 | Mahmoud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carrier Corporation (Palm Beach Gardens, Florida) |
| ASSIGNEE(S) | Carrier Corporation (Palm Beach Gardens, Florida) |
| INVENTOR(S) | Ahmad M. Mahmoud (Windsor, Connecticut); Jinliang Wang (Ellington, Connecticut); Frederick J. Cogswell (Glastonbury, Connecticut); Parmesh Verma (Manlius, New York) |
| ABSTRACT | A method for operating a heat pump (20; 300) includes operating in a cooling mode wherein heat is absorbed by refrigerant in the indoor heat exchanger (26) and rejected by refrigerant in the outdoor heat exchanger (24). The heat pump switches to operation in a heating mode wherein heat is rejected by refrigerant in the indoor heat exchanger, heat is absorbed by refrigerant in the outdoor heat exchanger, and there is an ejector (60) motive flow and ejector secondary flow. In the heating mode a refrigerant pressure (PH) or temperature (TL) is measured and, responsive to the measured refrigerant pressure or temperature, at least one of a fan speed is changed and a needle (132) of the ejector is actuated. |
| FILED | Friday, August 25, 2023 |
| APPL NO | 18/238185 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 13/00 (20130101) Original (OR) Class F25B 41/42 (20210101) F25B 49/02 (20130101) F25B 2313/0293 (20130101) F25B 2341/0013 (20130101) F25B 2400/23 (20130101) F25B 2600/11 (20130101) F25B 2700/1931 (20130101) F25B 2700/1933 (20130101) F25B 2700/21162 (20130101) F25B 2700/21163 (20130101) F25B 2700/21174 (20130101) F25B 2700/21175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181254 | Mechinus et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as Represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jesse R. Mechinus (Bloomington, Indiana); Gerald Miller (Bloomington, Indiana); James L Stewart (Bloomington, Indiana) |
| ABSTRACT | Provided is a an active shooter monitoring and incapacitation system that can augment active security forces control during emergencies at schools, churches, military, and government institutions. The system includes one or more cameras that are controlled remotely by an operator. If a hostile person or active shooter is located, a warning system, such as an audio/visual alert and laser dazzler is activated to alert nearby people of the threat to vacate and to notify the active shooter that he/she is required to halt any hostile actions. If the hostile person does not cease his activities, one or more stun guns contained within the system are then utilized to incapacitate the active shooter with a large electric shock, thereby incapacitating the person until the authorities arrive. |
| FILED | Tuesday, April 26, 2022 |
| APPL NO | 17/729543 |
| ART UNIT | 2689 — Signal Processing and Control Processing in Disk Drives |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/00 (20130101) Original (OR) Class F41H 13/0012 (20130101) F41H 13/0056 (20130101) F41H 13/0087 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/54 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 15/00 (20130101) G08B 21/02 (20130101) Pictorial Communication, e.g Television H04N 7/181 (20130101) H04N 23/66 (20230101) H04N 23/695 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181447 | Burns et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sloan C. Burns (King George, Virginia); Luke Andrew Martin (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Sloan C. Burns (King George, Virginia); Luke Andrew Martin (King George, Virginia) |
| ABSTRACT | A test fixture is provided for dropping an article from a height to a floor, with the article oriented in relation to the floor at a select angle. The fixture includes a column frame, an overhead beam, a carriage, first and second guy wires, first and second spools, and first and second chains. The frame supports first and second guide arms on opposing sides. The overhead beam has a distance span substantially parallel to the floor. The guy wires attach to the beam separated the span and pass through the guide arms. The spools receive the corresponding guy wires. The chains suspend the article from the carriage above the floor. Upon release of the guy wires, the carriage falls until contact with the guide arms while the article contacts the floor. |
| FILED | Monday, September 12, 2022 |
| APPL NO | 17/942356 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/303 (20130101) Original (OR) Class G01N 2203/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181589 | Benedick |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Andrew Benedick (Stow, Massachusetts) |
| ABSTRACT | Binary-phase-shift-key, phase-modulated waveforms with gigahertz bandwidths, suitable for kilowatt-class fiber amplifiers, can be narrowed back to the source laser's linewidth via second-harmonic, sum-frequency, or difference-frequency generation in a second-order nonlinear crystal. The spectrum of an optical signal phase-modulated with a pseudo-random bit sequence (PRBS) waveform recovers its original optical spectrum when frequency-doubled using second-harmonic generation (SHG). Conceptually, the PRBS waveform is cancelled by the SHG process, and the underlying laser spectrum is converted to the second-harmonic wavelength as though the PRBS modulation were not present. The same cancellation is possible with sum-frequency generation (SFG) and difference frequency generation (DFG), making it possible to construct high-power, narrow-linewidth lasers at wavelengths from the visible to the long-wave infrared. Using ytterbium-, erbium-, thulium-, and neodymium-doped fibers with SHG, SFG and DFG processes allows generation of high-power beams with very narrowband optical spectra and wavelengths from below 400 nm to beyond 5 μm. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/817859 |
| ART UNIT | 3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/04 (20130101) G01S 19/44 (20130101) Original (OR) Class G01S 19/46 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181772 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Liang Feng (Wynnewood, Pennsylvania); Han Zhao (Philadelphia, Pennsylvania) |
| ABSTRACT | An optical switch device and a related method for defining a topological light transport channel in a photonic lattice are provided. An exemplary optical switch device includes a photonic lattice including a photonic topological microring array comprising a plurality of site rings coupled via a plurality of anti-resonant link rings, a plurality of input light ports and a plurality of output light ports located at the plurality of site rings, wherein the plurality of input light ports and the plurality of output light ports are respectively connected by a plurality of topological light transport channels. The optical switch device is further configured such that each of the topological light transport channels is defined by a gain domain area that is produced by a corresponding patterned optical pumping beam emitted onto the photonic topological microring array. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642396 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/313 (20130101) Original (OR) Class G02F 2202/102 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12182615 | Hornung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | Micron Technology, Inc. (Boise, Idaho) |
| INVENTOR(S) | Bryan Hornung (Plano, Texas); David Patrick (McKinney, Texas) |
| ABSTRACT | Devices and techniques for handling breakpoints in a multi-element processor are described herein. A compute node includes a hybrid threading processor and hybrid threading fabric, where the hybrid threading fabric comprises a plurality of memory-compute tiles, where each of the memory-compute tiles include respective processing and storage elements used to execute a kernel, and where each of the memory-compute tiles includes a breakpoint controller to initiate a breakpoint for the plurality of memory-compute tiles. |
| FILED | Wednesday, August 31, 2022 |
| APPL NO | 17/899710 |
| ART UNIT | 2183 — Computer Architecture and I/O |
| CURRENT CPC | Electric Digital Data Processing G06F 9/485 (20130101) Original (OR) Class G06F 9/30076 (20130101) G06F 11/3612 (20130101) G06F 11/3644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
12182950 — Remote expert method and system utilizing quantitative quality assurance in mixed reality
| US 12182950 | Greunke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| INVENTOR(S) | Larry Clay Greunke (Seaside, California) |
| ABSTRACT | This disclosure and exemplary embodiments described herein provide a Parallel Content Authoring Method and Tool for Procedural Guidance, and a Remote Expert Method and System Utilizing Quantitative Quality Assurance in Mixed Reality. The implementation described herein is related to the generation of content/instruction set that can be viewed in different modalities, including but not limited to mixed reality, VR, audio text, however it is to be understood that the scope of this disclosure is not limited to such application. |
| FILED | Friday, February 17, 2023 |
| APPL NO | 18/111458 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Electric Digital Data Processing G06F 16/24573 (20190101) Image Data Processing or Generation, in General G06T 13/20 (20130101) G06T 17/20 (20130101) G06T 19/006 (20130101) Original (OR) Class G06T 2200/24 (20130101) G06T 2210/52 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) G09B 19/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183535 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); A*STAR (Singapore, Singapore) |
| INVENTOR(S) | Peng Zhang (Okemos, Michigan); Lin Wu (Jadescape, Singapore); Xiao Xiong (The Tennery, Singapore); Yang Zhou (Lansing, Michigan) |
| ABSTRACT | A dielectric coated plasmonic photoemitter is provided. An aspect of the present photonic apparatus includes a conductive photoemitter including a dielectric material coating or layered on a metallic core. The dielectric material being configured to enhance a local optical field strength and current density of the photoemitter as compared to a bare photoemitter without the dielectric layer. The dielectric layered photoemitter being tunable to transmit photoemissions from corners thereof with different photonic characteristics depending on a laser wavelength pulse received. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749360 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/34 (20130101) Original (OR) Class H01J 23/04 (20130101) H01J 25/34 (20130101) H01J 37/26 (20130101) H01J 37/073 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 7/22 (20130101) H05H 9/00 (20130101) H05H 15/00 (20130101) H05H 2007/025 (20130101) H05H 2007/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183574 | Hersam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jung-Woo Ted Seo (Naperville, Illinois); Jian Zhu (Tianjin, China PRC) |
| ABSTRACT | Printable inks based on a 2D semiconductor, such as MoS2, and its applications in fully inkjet-printed optoelectronic devices are disclosed. Specifically, percolating films of MoS2 nanosheets with superlative electrical conductivity (10−2 s m−1) are achieved by tailoring the ink formulation and curing conditions. Based on an ethyl cellulose dispersant, the MoS2 nanosheet ink also offers exceptional viscosity tunability, colloidal stability, and printability on both rigid and flexible substrates. Two distinct classes of photodetectors are fabricated based on the substrate and post-print curing method. While thermal annealing of printed devices on rigid glass substrates leads to a fast photoresponse of 150 μs, photonically annealed devices on flexible polyimide substrates possess high photoresponsivity exceeding 50 mA/W. The photonically annealed photodetector also significantly reduces the curing time down to the millisecond-scale and maintains functionality over 500 bending cycles, thus providing a direct pathway to roll-to-roll manufacturing of next-generation flexible optoelectronics. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380747 |
| ART UNIT | 2812 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02538 (20130101) Original (OR) Class H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02601 (20130101) H01L 21/02606 (20130101) H01L 31/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183814 | Bentley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GlobalFoundries U.S. Inc. (Malta, New York) |
| ASSIGNEE(S) | GLOBALFOUNDRIES U.S. Inc. (Malta, New York) |
| INVENTOR(S) | Steven J. Bentley (Menands, New York); Francois Hebert (San Mateo, California); Lawrence Selvaraj Susai (South Burlington, Vermont); Johnatan A Kantarovsky (South Burlington, Vermont); Michael Zierak (Colchester, Vermont); Mark D. Levy (Williston, Vermont); John Ellis-Monaghan (Grand Isle, Vermont) |
| ABSTRACT | The present disclosure relates to semiconductor structures and, more particularly, to multi-channel transistors and methods of manufacture. The structure includes: a gate structure; a single channel layer in a channel region under the gate structure; a drift region adjacent to the gate structure; and multiple channel layers in the drift region coupled to the single channel layer under the gate structure. |
| FILED | Monday, March 25, 2024 |
| APPL NO | 18/615615 |
| ART UNIT | 2813 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/2003 (20130101) H01L 29/7783 (20130101) Original (OR) Class H01L 29/7786 (20130101) H01L 29/66431 (20130101) H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183968 | Sechrist et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Zachary A Sechrist (Aiken, South Carolina); Christopher G. Yelton (Ridgecrest, California); Mark B. Moran (Ridgecrest, California); Linda F. Johnson (Ridgecrest, California); Joseph E. Estevez (Ridgecrest, California); Gretchen H. Hefley (Ridgecrest, California) |
| ABSTRACT | The embodiments are directed to systems having an array in intimate adjacent contact with a substrate foundation. The array has a plurality of radio frequency (RF) witness films overlain on the substrate foundation. Each RF witness film is a unit cell defined in a three-dimensional coordinate frame of reference, and is centered at an origin of the three-dimensional coordinate frame of reference. Each RF witness film in the plurality of RF witness films is equally-spaced from adjacent RF witness films. |
| FILED | Tuesday, March 12, 2024 |
| APPL NO | 18/602911 |
| ART UNIT | 2858 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/08 (20130101) Antennas, i.e Radio Aerials H01Q 1/38 (20130101) Original (OR) Class H01Q 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183981 | Chieh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Naval Information Warfare Center Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jia-Chi Samuel Chieh (San Diego, California) |
| ABSTRACT | A method for radiating a co-located antenna including radiating the co-located antenna using a dual mode, where the co-located antenna has an inter-element spacing of about 1λ and the dual mode includes a TM11 mode and a TM21 mode. The TM11 mode is radiated to generate a TM11 far field pattern, where the TM11 mode has a broadside pattern characterized with a beam peak at broadside and the TM11 mode produces grating lobes in addition to the beam peak at broadside. The TM21 mode is radiated to generate a TM21 far field pattern orthogonal to the TM11 far field pattern, thereby causing the TM21 mode to produce a null at broadside to suppress the grating lobes produced by the TM11 mode. |
| FILED | Tuesday, August 08, 2023 |
| APPL NO | 18/366863 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 5/16 (20130101) Antennas, i.e Radio Aerials H01Q 9/0478 (20130101) H01Q 21/10 (20130101) H01Q 21/293 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183986 | Kalateh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Mohammad Mahdi Honari Kalateh (Middleton, Wisconsin); Nader Behdad (Oregon, Wisconsin); John H. Booske (McFarland, Wisconsin) |
| ABSTRACT | A phase shift element includes an antenna, a first dielectric layer, a ground plane mounted to a first surface of the first dielectric layer, a reflecting circuit, and a single antenna-reflector line connected between the antenna and the reflecting circuit through the ground plane and the first dielectric layer. The antenna-reflector line is formed of a conducting material. The reflecting circuit is mounted to a second surface of the first dielectric layer. The first surface is opposite the second surface. The reflecting circuit is configured to reflect a signal received on the single antenna-reflector line from the antenna back to the antenna on the single antenna-reflector line. The reflecting circuit is further configured to be switchable between four different impedance levels that each provide a different phase shift when the signal is reflected by the reflecting circuit. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568015 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/48 (20130101) H01Q 3/36 (20130101) Original (OR) Class H01Q 3/46 (20130101) H01Q 9/0407 (20130101) H01Q 19/10 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184259 | Lekavicius et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Ignas Lekavicius (Eugene, Oregon); Hailin Wang (Eugene, Oregon) |
| ABSTRACT | A back side of a diamond or other substrate is thinned using plasma etches and a mask situated away from the back side by a spacer having a thickness between 50 μm and 250 μm. Typically, a combined RIE/ICP etch is used to thin the substrate from 20-40 μm to less than 1 μm. For applications in which color centers are implanted or otherwise situated on a front side of the diamond substrate, after thinning, a soft graded etch is applied to reduce color center linewidth, particularly for nitrogen vacancy (NV) color centers. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466979 |
| ART UNIT | 1716 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0042 (20130101) G03F 7/2035 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184683 | Cam |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Hasan Cam (Columbia, Maryland) |
| ABSTRACT | A technique for providing cyber resilience by integrating autonomous adversary and defender agents, deep learning, and graph thinking. An automated competitive environment of autonomous adversary and defender agents is provided such that the adversary agent can emulate the adversary activities, patterns, and intentions using all available cybersecurity measurements and observations, and, the defender agent can generate and suggest the best possible appropriate actions to mitigate or prevent adversary activities while recovering or protecting assets. An automated cyber resilience system with autonomous agents is provided using machine learning and security analytics to first predict the current and future adversary activities and then provide an automated critical asset protection and recovery by enabling agents to take appropriate reactive and pro-active actions at each time step to prevent, recover, or mitigate adversary activities over enterprise and tactical networks. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 16/866583 |
| ART UNIT | 2496 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/145 (20130101) H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184695 | Raj |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Alex E. Raj (McLean, Virginia) |
| ABSTRACT | Described are systems, methods, and computer-program product embodiments for providing Session Initiation Protocol (SIP) network security. In some embodiments, a SIP processing system includes a SIP device configured to receive a packet stream from a first SIP user agent and facilitate a SIP communication session between the first SIP user agent and a second SIP user agent. The SIP device receives the SIP messages in the SIP communication session and opens one or more socket connections with one or more security systems. The SIP device transmits metadata of the SIP messages to the one or more security systems configured to detect threats. Based on a threat status generated by and received from the one or more security systems, the SIP device controls the SIP communication session. |
| FILED | Monday, November 13, 2023 |
| APPL NO | 18/507793 |
| ART UNIT | 2499 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/166 (20130101) H04L 63/168 (20130101) Original (OR) Class H04L 65/1069 (20130101) H04L 65/1104 (20220501) H04L 69/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184796 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Young L Kim (West Lafayette, Indiana); Jung Woo Leem (West Lafayette, Indiana) |
| ABSTRACT | A method of generating a physically unclonable function (PUF) for pharmaceutical authentication is disclosed which includes generating an edible (PUF), affixing the edible PUF onto a pharmaceutical in a random distribution, and generating a cryptographic key based on the randomly distributed and affixed edible PUF. The present disclosure generally relates to counterfeit measures, and in particular, to an arrangement concerning an edible unclonable function counterfeit measure. |
| FILED | Saturday, August 15, 2020 |
| APPL NO | 17/768289 |
| ART UNIT | 2641 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/42 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/018 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184797 | Cambou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona); GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (Rome, New York) |
| INVENTOR(S) | Bertrand F. Cambou (Flagstaff, Arizona); Julie Heynssens (Flagstaff, Arizona); Ian Burke (Flagstaff, Arizona); Brit Riggs (Flagstaff, Arizona); Jack Garrard (Flagstaff, Arizona); Manuel Aguilar Rios (Flagstaff, Arizona); Donald Telesca (Rome, New York); H. Shelton Jacinto (Rome, New York) |
| ABSTRACT | Systems and methods for the generation and use of session keys supporting secure communications between a client and server device are disclosed. The client hashes each of a series of passwords a first number of times. The hashed passwords are sent to a server. The server applies the hashed password to an array of PUF devices, and receives an initial response bitstream which is stored. The client later hashes each of the series of passwords a second number of times, which is less than the first number, and these are sent to the server. The server continues to hash the second message digest, generate PUF responses, and compare the result to the initially stored responses. For each password, the number of hashes necessary to achieve a match is a partial session key. Latency is improved by an array of separately addressable PUFs, each producing a partial session key. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/954222 |
| ART UNIT | 2494 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0863 (20130101) H04L 9/3239 (20130101) H04L 9/3268 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12185619 | Forrest |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (, None) |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method for fabricating an organic electronic device comprises providing a plurality of photoresist structures on a substrate, the substrate having a first electrode layer, the photoresist structures having a bottom surface attached to the substrate and a top surface opposite the bottom surface, the top surface having a dimension greater than a dimension of the bottom surface, positioning a mask over the structures, the mask having a plurality of openings, and depositing an emissive material over the substrate through at least one of the plurality of openings to form at least one emissive element. An organic electronic device and a method of fabricating an organic electronic component are also described. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491050 |
| ART UNIT | 2896 — Semiconductors/Memory |
| CURRENT CPC | Organic electric solid-state devices H10K 59/122 (20230201) H10K 71/166 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12185620 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| INVENTOR(S) | Shangshang Chen (Chapel Hill, North Carolina); Jinsong Huang (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein are surface treatment methods for removing one or more surface defect layers from polycrystalline films, polycrystalline films that are free of one or more defect surface layers, and use of the films in solar cells. In certain embodiments, the method is conducted by means of an adhesive tape or mechanical polishing. As described herein, solar cells containing the surface treated perovskite films show enhanced efficiency and stability. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 18/245387 |
| ART UNIT | 1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 7/0028 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) C07F 19/00 (20130101) Organic electric solid-state devices H10K 30/40 (20230201) H10K 30/50 (20230201) H10K 71/20 (20230201) Original (OR) Class H10K 85/50 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 12179173 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | Shengqian Ma (Tampa, Florida); Qi Sun (Tampa, Florida); Briana Aguila (Tampa, Florida) |
| ABSTRACT | Compositions are provided for efficient uranium extraction, for example from wastewater, seawater, or other water sources. The compositions can include a functionalized porous organic polymer functionalized with one or more uranium binding moieties, e.g. having a plurality of amidoxime or amidrazone groups covalently attached thereto. The compositions can include covalent organic frameworks, porous aromatic frameworks, and various porous organic polymers, especially those having a hierarchical pore size distribution over a range of pore sizes. The compositions can have functional groups such as amidoxime or an amidrazone covalently attached thereto. The hierarchical pore size distribution can be determined based upon at least 60% of the pore sizes in the range of pore sizes having a pore volume of at least 0.01 cm3 g−1 in the pore size distribution at 77 K. Methods of making the compositions and methods of using the compositions are also provided. |
| FILED | Thursday, February 16, 2023 |
| APPL NO | 18/170463 |
| ART UNIT | 1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) Original (OR) Class B01J 20/2808 (20130101) B01J 20/3085 (20130101) B01J 20/28066 (20130101) B01J 20/28071 (20130101) B01J 20/28083 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 112/34 (20130101) C08F 2810/00 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 9/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179179 | Kuhn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | John Kuhn (Wesley Chapel, Florida); Babu Joseph (Tampa, Florida); Yang He (Tampa, Florida) |
| ABSTRACT | The present disclosure provides a composition. In an embodiment, a catalyst composition is provided and includes from 85 mol % to 95 mol % iron metal, and from 15 mol % to 5 mol % indium metal, wherein mol % is based on total moles of iron metal and indium metal. Also provided is a process of contacting, under reaction conditions, a gaseous mixture of carbon monoxide, hydrogen and optionally water with the catalyst composition. The process includes forming a reaction product composed of light olefins. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/691082 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) B01J 23/825 (20130101) Original (OR) Class B01J 37/18 (20130101) Acyclic or Carbocyclic Compounds C07C 1/041 (20130101) C07C 1/044 (20130101) C07C 1/048 (20130101) C07C 1/0445 (20130101) C07C 2521/04 (20130101) C07C 2523/825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179237 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sortera Technologies, Inc. (Markle, Indiana) |
| ASSIGNEE(S) | SORTERA TECHNOLOGIES, INC. (Markle, Indiana) |
| INVENTOR(S) | Nalin Kumar (Fort Wayne, Indiana); Manuel Gerardo Garcia, Jr. (Austin, Texas); Isha Kamleshbhai Maun (Arlington, Texas) |
| ABSTRACT | A material sorting system sorts materials utilizing an x-ray fluorescence and/or a vision system that implements a machine learning system in order to identify or classify each of the materials, which are then sorted into separate groups based on such an identification or classification determining that the materials are composed of either wrought aluminum, extruded aluminum, or cast aluminum. The system is capable of sorting between cast aluminum alloys and also between wrought aluminum alloys. |
| FILED | Monday, January 15, 2024 |
| APPL NO | 18/412987 |
| ART UNIT | 3653 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179633 | Sujan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Vivek Sujan (Oak Ridge, Tennessee) |
| ABSTRACT | An improved power-split control system for managing a load profile of a fuel cell in a fuel cell electric vehicle (FCEV) is provided. The power-split control system is operable to actively manage the power demand between the fuel cell and the battery of a FCEV to optimize the operational life of the fuel cell. The power-split control system can use information gathered solely from historical drive cycle data or from historical drive cycle data combined with look-ahead eHorizon data. The power-split control system meets a power demand by operating the powertrain in either a battery charge sustaining mode or a battery charge depletion mode. The power-split control system is also configured to control the power distribution (to the electric motor) from the fuel cell and the battery in a manner that minimizes the degradation of the fuel cell. |
| FILED | Tuesday, September 12, 2023 |
| APPL NO | 18/367054 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 3/0053 (20130101) B60L 50/75 (20190201) B60L 58/13 (20190201) B60L 58/16 (20190201) B60L 58/40 (20190201) Original (OR) Class Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/13 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180130 | Ruddy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Daniel Ruddy (Arvada, Colorado); Jesse Evan Hensley (Arvada, Colorado); Joshua A. Schaidle (Arvada, Colorado); Connor Patrick Nash (Lakewood, Colorado); Anh The To (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a method that includes converting a gas stream that contains hydrogen (H2) and carbon monoxide (CO) to a second mixture that contains a hydrocarbon, for example, a hydrocarbon having between 3 and 15 carbon atoms, where the converting is performed using a first catalyst configured to convert H2 and CO to methanol, a second catalyst configured to convert methanol to dimethyl ether (DME), and a third catalyst configured to convert DME to the hydrocarbon. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401778 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/04 (20130101) B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 21/066 (20130101) B01J 23/72 (20130101) B01J 23/80 (20130101) B01J 29/7007 (20130101) B01J 35/19 (20240101) B01J 2208/025 (20130101) B01J 2208/027 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class C07C 29/154 (20130101) C07C 41/09 (20130101) C07C 2521/04 (20130101) C07C 2521/06 (20130101) C07C 2521/08 (20130101) C07C 2523/06 (20130101) C07C 2523/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180230 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| INVENTOR(S) | Mark E. Thompson (Anaheim Hills, California); Peter I. Djurovich (Long Beach, California); Rasha Hamze (Los Angeles, California); Shuyang Shi (Los Angeles, California); Moon Chul Jung (Los Angeles, California) |
| ABSTRACT | A compound selected from the group consisting of Formula I, Formula II, and Formula III, wherein ring A, ring B, and ring C are independently a five-membered or six-membered, carbocyclic or heterocyclic ring, each of which is optionally aromatic; ring W of Formula I is a 6-membered heterocyclic ring, and ring W of Formula II or Formula III is a 5-membered or 6-membered heterocyclic ring; L is a monodentate ligand with a metal coordinating member selected from the group consisting of C, N, O, S, and P; and M is a metal selected from the group consisting of Cu, Au, and Ag. |
| FILED | Thursday, November 15, 2018 |
| APPL NO | 16/191604 |
| ART UNIT | 1786 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 1/10 (20130101) Original (OR) Class C07F 1/12 (20130101) Organic electric solid-state devices H10K 50/11 (20230201) H10K 85/371 (20230201) H10K 2101/10 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180269 | Pasqualini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Renata Pasqualini (New Brunswick, New Jersey); Wadih Arap (New Brunswick, New Jersey); Fernanda Iamassaki Staquicini (New Brunswick, New Jersey); Fortunato Ferrara (Santa Fe, New Mexico); Sara D'Angelo (Santa Fe, New Mexico); Andrew R. M. Bradbury (Santa Fe, New Mexico) |
| ABSTRACT | Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided. |
| FILED | Friday, June 10, 2022 |
| APPL NO | 17/837943 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/07 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6817 (20170801) A61K 47/6843 (20170801) A61K 47/6849 (20170801) A61K 47/6891 (20170801) A61K 47/68031 (20230801) A61K 47/68033 (20230801) A61K 49/0008 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2866 (20130101) C07K 16/3023 (20130101) C07K 2317/21 (20130101) C07K 2317/35 (20130101) C07K 2317/55 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) C12N 15/1037 (20130101) C12N 2810/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5011 (20130101) G01N 33/57423 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180338 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATON, INC. (Ames, Iowa) |
| ASSIGNEE(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| INVENTOR(S) | Nacu Hernandez (Ames, Iowa); Mengguo Yan (San Jose, California); Eric William Cochran (Ames, Iowa); John Edward Matthiesen (Hillsboro, Oregon); Jean-Philippe Tessonnier (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623237 |
| ART UNIT | 1766 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180391 | Hun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Diana Hun (Oak Ridge, Tennessee); Pengfei Cao (Oak Ridge, Tennessee); Xiao Zhao (Oak Ridge, Tennessee); Zoriana Demchuk (Oak Ridge, Tennessee); Jiancheng Luo (Oak Ridge, Tennessee); Tomonori Saito (Oak Ridge, Tennessee) |
| ABSTRACT | A joint sealing system for prefabricated building components is provided. The joint sealing system includes a first component including a first surface, and a second component including a second surface that is mateable with the first surface. The first and second surfaces define a joint. A sealant composition is disposed on one of the first surface or the second surface. Pressure exerted when the second surface is mated with the first surface triggers curing of the sealant composition to join the first and second components and to seal the joint between the first and second components. A method of joining and sealing two prefabricated building components is also provided. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591886 |
| ART UNIT | 3636 — Static Structures, Supports and Furniture |
| CURRENT CPC | Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/00 (20130101) C09J 11/08 (20130101) C09J 133/08 (20130101) C09J 133/12 (20130101) Original (OR) Class C09J 2433/00 (20130101) C09J 2463/00 (20130101) C09J 2475/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180516 | Bowie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | James U. Bowie (Los Angeles, California); Meaghan Valliere (Leominster, Massachusetts); Tyler P. Korman (Sierra Madre, California); Nicholas Woodall (Knoxville, Tennessee) |
| ABSTRACT | Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions. |
| FILED | Monday, October 24, 2022 |
| APPL NO | 18/049221 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/22 (20130101) C12P 7/42 (20130101) C12P 9/00 (20130101) C12P 17/06 (20130101) Enzymes C12Y 102/03003 (20130101) C12Y 205/01039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180562 | Williamson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Energy, United States Department of (Washington, District of Columbia) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Mark A. Williamson (Naperville, Illinois); James L. Willit (Batavia, Illinois); Stanley G. Wiedmeyer (Glen Ellyn, Illinois); Terry R. Johnson (Wheaton, Illinois); Javier Figueroa (Andover, Kansas); Terry Alan Cruse (Lisle, Illinois) |
| ABSTRACT | According to one aspect of the invention, a system to separate salt from uranium. The system has a vessel, a heater, a pump, and a condenser. The vessel is adapted to receive a uranium that has a salt concentration. The heater heats the uranium for a period of time, causing the salt to turn into a salt vapor and the uranium to melt. The melted uranium releases the salt vapor. The pump circulates an inert gas that carries the salt vapor away from the melted uranium. The condenser is adapted to receive the salt vapor. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 16/845558 |
| ART UNIT | 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Separation B01D 1/0011 (20130101) B01D 1/14 (20130101) B01D 1/0082 (20130101) B01D 5/006 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 9/02 (20130101) C22B 9/05 (20130101) C22B 9/006 (20130101) C22B 60/0213 (20130101) Original (OR) Class C22B 60/0286 (20130101) Furnaces, Kilns, Ovens, or Retorts in General; Open Sintering or Like Apparatus F27B 2014/004 (20130101) F27B 2014/0875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180567 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Iver E. Anderson (Ames, Iowa); Emma Marie Hamilton White (Des Moines, Iowa); Duane Johnson (Ames, Iowa); Nicolas Argibay (Ames, Iowa); Andrew B. Kustas (Elizabeth, Colorado); Michael Chandross (Albuquerque, New Mexico); Raymond V. Puckett (Albuquerque, New Mexico) |
| ABSTRACT | Refractory-reinforced multiphase high entropy alloys (RHEAs) advantageously providing high strength and fracture toughness in an as-AM deposited condition and other conditions are described. |
| FILED | Monday, November 21, 2022 |
| APPL NO | 17/803779 |
| ART UNIT | 1738 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) B22F 3/105 (20130101) B22F 9/04 (20130101) B22F 9/082 (20130101) B22F 10/28 (20210101) B22F 2202/13 (20130101) B22F 2301/052 (20130101) B22F 2304/10 (20130101) B22F 2998/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Alloys C22C 14/00 (20130101) C22C 30/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180610 | Eom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Chang-Beom Eom (Madison, Wisconsin); Jungwoo Lee (Madison, Wisconsin); Jieun Kim (Madison, Wisconsin) |
| ABSTRACT | Apparatus and methods for growing films of complex layered metal oxides with high stoichiometries and high crystal qualities are provided. The layered complex metal oxides include two or more metals and oxygen and have a layered structure. The methods, which are referred to as hybrid pulsed laser deposition (hybrid PLD), synergistically combine the advantages of molecular beam epitaxy (MBE) and pulsed laser deposition (PLD) to grow complex metal oxide films that include metals with very different vapor pressures. |
| FILED | Monday, January 09, 2023 |
| APPL NO | 18/151550 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) Original (OR) Class C30B 29/24 (20130101) C30B 29/30 (20130101) C30B 29/32 (20130101) C30B 29/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180893 | Terwilliger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RTX CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Neil J. Terwilliger (Cheshire, Connecticut); Joseph B. Staubach (Colchester, Connecticut) |
| ABSTRACT | A propulsion system for an aircraft includes a core engine that includes a core flow path where air is compressed in a compressor section, communicated to a combustor section, mixed with a gaseous fuel and ignited to generate an exhaust gas flow that is expanded through a turbine section. A fuel system supplies a fuel to the combustor through a fuel flow path, a first heat exchanger thermally communicates a first heat load into a cooling flow, a turboexpander where a heated cooling flow from the first heat exchanger is expanded to generate shaft power and cooled to provide a cooled cooling flow, and a second heat exchanger thermally communicates a second heat load to the cooled cooling flow that is communicated from the turboexpander, cooling flow from the second heat exchanger is communicated to the combustor section. |
| FILED | Monday, June 05, 2023 |
| APPL NO | 18/329044 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/22 (20130101) F02C 3/30 (20130101) F02C 7/141 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180939 | Singal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GE Infrastructure Technology LLC (Greenville, South Carolina) |
| INVENTOR(S) | Kalpesh Singal (Ballston Spa, New York); Mustafa Tekin Dokucu (Latham, New York); Fernando Javier D'Amato (Niskayuna, New York); Georgios Boutselis (Niskayuna, New York) |
| ABSTRACT | A method for providing backup control for a supervisory controller of at least one wind turbine includes observing, via a learning-based backup controller of the at least one wind turbine, at least one operating parameter of the supervisory controller under normal operation. The method also includes learning, via the learning-based backup controller, one or more control actions of the at least one wind turbine based on the operating parameter(s). Further, the method includes receiving, via the learning-based backup controller, an indication that the supervisory controller is unavailable to continue the normal operation. Upon receipt of the indication, the method includes controlling, via the learning-based backup controller, the wind turbine(s) using the learned one or more control actions until the supervisory controller becomes available again. Moreover, the control action(s) defines a delta that one or more setpoints of the wind turbine(s) should be adjusted by to achieve a desired outcome. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698040 |
| ART UNIT | 2116 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Wind Motors F03D 7/045 (20130101) F03D 7/046 (20130101) Original (OR) Class F03D 7/047 (20130101) F03D 7/0264 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2270/328 (20130101) F05B 2270/335 (20130101) F05B 2270/709 (20130101) F05B 2270/1074 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181152 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RTX Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RTX Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Justin M. Locke (Tolland, Connecticut) |
| ABSTRACT | A fuel nozzle for a gas turbine engine combustor includes a fuel nozzle assembly including an inflow tube disposed along and a nozzle axis, the inflow tube defining an inner air passage, and a liquid swirler concentrically disposed about the inflow tube, the liquid swirler including a liquid swirler inner wall, liquid swirler outer wall having a liquid swirler outer wall end portion angled radially inward toward the nozzle axis, and an annular liquid passage defined therebetween. The fuel nozzle assembly further includes a radial air swirler (RAS) concentrically disposed about the liquid swirler outer wall, the RAS including an RAS inner wall having an RAS inner wall end portion angled radially inward toward the nozzle axis such that it is parallel to the liquid swirler outer wall end portion, an RAS outer wall having an end cap at a downstream-most position, and an annular gas passage defined therebetween. The end cap includes a radiused inner surface and an outer surface. |
| FILED | Thursday, April 04, 2024 |
| APPL NO | 18/626818 |
| ART UNIT | 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/14 (20130101) Original (OR) Class F23R 3/36 (20130101) F23R 3/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181421 | Roach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Robert A. Roach (Idaho Falls, Idaho); Andrea M. Jokisaari (Idaho Falls, Idaho); Michael D. McMurtrey (Idaho Falls, Idaho); Geoffrey L. Beausoleil (Idaho Falls, Idaho); Carolyn L. Seepersad (Austin, Texas) |
| ABSTRACT | A test capsule for measuring at least one property of a material exposed to nuclear radiation comprises a lattice structure configured to exhibit a change in at least one property responsive to exposure to nuclear radiation. The lattice structure comprises a first strut and a second strut connected to the first strut at a node. Related test capsules and methods are also described. |
| FILED | Friday, June 24, 2022 |
| APPL NO | 17/808944 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181437 | Cieslewski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Grzegorz Cieslewski (Orlando, Florida); Xuhua Gao (Stanford, California); Ryan Falcone Hess (Sandia Park, New Mexico); Avery T. Cashion, IV (Albuquerque, New Mexico); William Corbin (Rio Rancho, New Mexico); Sasha Egan (Belen, New Mexico); Roland N. Horne (Stanford, California) |
| ABSTRACT | The present disclosure is directed to systems, methods and tools that measure ionic concentrations and downhole enthalpy of a flowing geothermal fluid in real-time at high-temperature and pressure. The systems, methods and tools include measuring the concentration of selected naturally occurring ions found in the liquid phase of the geothermal fluid throughout the wellbore using novel electrochemical sensor technologies. The change in liquid-phase ion concentration will be used to calculate the proportion of liquid to steam and allow for accurate enthalpy measurements. The techniques and technologies described here can be applied to any application of electrochemical sensing in extreme environments. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474560 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Geothermal Collectors; Geothermal Systems F24T 10/20 (20180501) F24T 10/30 (20180501) F24T 2201/00 (20180501) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/04 (20130101) G01K 13/02 (20130101) G01K 13/026 (20210101) G01K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/333 (20130101) G01N 27/4162 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181773 | Pooser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Raphael C. Pooser (Oak Ridge, Tennessee); Benjamin J. Lawrie (Oak Ridge, Tennessee); Petro Maksymovych (Oak Ridge, Tennessee) |
| ABSTRACT | A truncated non-linear interferometer-based sensor system includes an input port that receives an optical beam and a non-linear amplifier that amplifies the optical beam with a pump beam and renders a probe beam and a conjugate beam. The system's local oscillators have a relationship with the respective beams. The system includes a sensor that transduces an input with the probe beam and the conjugate beam or their respective local oscillators. It includes one or more phase-sensitive detectors that detect a phase modulation between the respective local oscillators and the probe beam and the conjugate beam. Output from the phase-sensitive-detectors is based on the detected phase modulation. The phase-sensor-detectors include measurement circuitry that measure the phase signals. The measurement is the sum or difference of the phase signals in which the measured combination exhibit a quantum noise reduction in an intensity difference or a phase sum or an amplitude difference quadrature. |
| FILED | Monday, January 23, 2023 |
| APPL NO | 18/100157 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) G01B 9/02003 (20130101) G01B 9/02079 (20130101) G01B 9/02081 (20130101) G01B 2290/55 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 20/02 (20130101) G01Q 60/24 (20130101) G01Q 60/38 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) G02F 1/3538 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/10076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181853 | Karandikar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Jaydeep M. Karandikar (Oak Ridge, Tennessee); Thomas A. Feldhausen (Oak Ridge, Tennessee); Kyle S. Saleeby (Oak Ridge, Tennessee); Kevin S. Smith (Oak Ridge, Tennessee); Tony L. Schmitz (Oak Ridge, Tennessee) |
| ABSTRACT | A Bayesian learning approach for stability boundary and optimal parameter identification in milling without the knowledge of the underlying tool dynamics or material cutting force coefficients. Different axial depth and spindle speed combinations are characterized by a probability of stability which is updated based upon whether the result is stable or unstable. A likelihood function incorporates knowledge of stability behavior. Numerical results show convergence to an analytical stability lobe diagram. An adaptive experimental strategy identifies optimal operating parameters that maximize material removal rate. An efficient and robust learning method to identify the stability lobe diagram and optimal operating parameters with a limited number of tests/data points. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529558 |
| ART UNIT | 2144 — Graphical User Interface and Document Processing |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/18 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12182569 | Kulkarni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Milind Kulkarni (West Lafayette, Indiana); Jad Hbeika (Santa Clara, California) |
| ABSTRACT | A graphics processing unit and methods for comping and executing instructions with opportunistic inter-path reconvergence are provided. An single instruction multiple thread (SIMT) stack of graphics processing unit may store data entries, each data entry comprising an operand mask. The operand mask may include bits corresponding to threads of a warp. The graphics processing unit core may access an instruction for an entry on the SIMT stack. Each of the threads may execute the instruction using either a first set of operands or a second set of operands depending on the corresponding bits of the operand mask. |
| FILED | Friday, June 30, 2023 |
| APPL NO | 18/217062 |
| ART UNIT | 2183 — Computer Architecture and I/O |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3887 (20130101) G06F 9/30018 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12182576 | Fleischer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Bruce M. Fleischer (Bedford Hills, New York); Thomas Winters Fox (Hopewell Junction, New York); Arpith C. Jacob (Dobbs Ferry, New York); Hans Mikael Jacobson (White Plains, New York); Ravi Nair (Briarcliff Manor, New York); Kevin John Patrick O'Brien (South Salem, New York); Daniel Arthur Prener (Croton-on-Hudson, New York) |
| ABSTRACT | A processor core includes a storage device which stores a composite very large instruction word (VLIW) instruction, an instruction unit which obtains the composite VLIW instruction from the storage device and decodes the composite VLIW instruction to determine an operation to perform, and a composite VLIW instruction execution unit which executes the composite VLIW instruction to perform the operation. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 16/731214 |
| ART UNIT | 2183 — Computer Architecture and I/O |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3836 (20130101) G06F 9/3853 (20130101) Original (OR) Class G06F 9/30065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183474 | Lahoda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Edward J. Lahoda (Edgewood, Pennsylvania); Frank A. Boylan (Ellewood City, Pennsylvania); Ho Q. Lam (Verona, Pennsylvania); Mitchell E. Nissley (Trafford, Pennsylvania); Raymond E. Schneider (South Windsor, Connecticut); Robert L. Oelrich (Columbia, South Carolina); Sumit Ray (Columbia, South Carolina); Radu Pomirleanu (Wexford, Pennsylvania); Zeses Karoutas (Lexington, South Carolina); Michael J. Hone (Prospect, Pennsylvania) |
| ABSTRACT | A control rod for a nuclear fuel assembly is described herein that includes a neutron absorbing material having a melting point greater than 1500° C. that does not form a eutectic with a melting point less than 1500° C., and may further include a cladding material having a melting point greater than 1500° C. The cladding material is selected from the group consisting of silicon carbide, zirconium, a zirconium alloy, tungsten, and molybdenum. The absorbing material is selected from the group consisting of Gd2O3, Ir, B4C, Re, and Hf. The metal cladding or the absorbing material may be coated with an anti-oxidation coating of Cr with or without a Nb intermediate layer. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/454196 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 30/00 (20130101) Nuclear Reactors G21C 1/08 (20130101) G21C 3/07 (20130101) G21C 3/328 (20130101) G21C 7/10 (20130101) Original (OR) Class G21C 7/24 (20130101) G21C 11/08 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183510 | Brambilla |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FASTCAP SYSTEMS CORPORATION (Wakefield, Massachusetts) |
| ASSIGNEE(S) | FASTCAP SYSTEMS CORPORATION (Wakefield, Massachusetts) |
| INVENTOR(S) | Nicolo Brambilla (Boston, Massachusetts) |
| ABSTRACT | An electric double layer capacitor (EDLC) is disclosed including: a first electrode including a first current collector and first plurality of carbon nanotubes (CNTs) disposed substantially directly upon the first current collector; a second electrode comprising a second current collector and second plurality of CNTs disposed substantially directly upon the second current collector; and an electrolyte disposed between and in contact with (e.g., wetting) the first and second electrodes. In some embodiments, the EDLC is configured to have a capacitive frequency window comprising about 1 Hz to about 50 Hz. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688211 |
| ART UNIT | 2848 — Electrical Circuits and Systems |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/28 (20130101) H01G 11/36 (20130101) H01G 11/52 (20130101) H01G 11/56 (20130101) H01G 11/60 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) H01G 11/68 (20130101) Original (OR) Class H01G 11/70 (20130101) H01G 11/80 (20130101) H01G 11/86 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/1807 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183880 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Lutgard C. De Jonghe (Lafayette, California); Bruce D. Katz (Moraga, California); Vitaliy Nimon (San Francisco, California) |
| ABSTRACT | A lithium ion-conductive solid electrolyte including a freestanding inorganic vitreous sheet of sulfide-based lithium ion conducting glass is capable of high performance in a lithium metal battery by providing a high degree of lithium ion conductivity while being highly resistant to the initiation and/or propagation of lithium dendrites. Such an electrolyte is also itself manufacturable, and readily adaptable for battery cell and cell component manufacture, in a cost-effective, scalable manner. |
| FILED | Tuesday, March 28, 2023 |
| APPL NO | 18/191615 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/056 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 50/44 (20210101) H01M 50/437 (20210101) H01M 50/489 (20210101) H01M 50/497 (20210101) H01M 2300/0068 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183901 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORIA (Oakland, California) |
| INVENTOR(S) | Zheng Chen (San Diego, California); Xiaolu Yu (La Jolla, California) |
| ABSTRACT | A process for low temperature hydrothermal relithiation of spent lithium-ion battery cathode materials adds a reducing agent to an aqueous Li solution at 80-100° C. followed by a short anneal to achieve complete recovery of composition, crystal structure, and electrochemical performance for heavily degraded cathode materials. |
| FILED | Wednesday, August 21, 2024 |
| APPL NO | 18/811672 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184123 | Islam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | NORTH CAROLINA STATE UNIVERSITY OFFICE OF RESEARCH COMMERCIALIZATION (Raleigh, North Carolina) |
| INVENTOR(S) | Md Sariful Islam (Raleigh, North Carolina); Iqbal Husain (Raleigh, North Carolina); Ritvik Chattopadhyay (Raleigh, North Carolina); Gregory D. Buckner (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to 3D airgap electric machines and winding embedded liquid cooling. In one example, an electric machine includes a stator assembly with stator windings supported by a stator core and an outer rotor assembly includes a radial plate surrounding the stator assembly and an endplate at a first end of the radial plate adjacent to the first end of the stator core. The stator windings can include a first portion extending along an axial length of the stator core and a second portion at a first end of the stator core that extends radially inward towards a shaft of the electric machine. The radial plate can include magnets distributed about the radial plate. In another example, a stator assembly includes stator windings supported by a stator core with a winding support including cooling channels distributed between the stator windings. The winding support can be nonmagnetic. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/482645 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Dynamo-electric Machines H02K 1/16 (20130101) H02K 1/17 (20130101) H02K 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184221 | Mayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORIA ENERGY (Sausalito, California) |
| ASSIGNEE(S) | NORIA ENERGY (Sausalito, California) |
| INVENTOR(S) | Alex Mayer (Mill Valley, California); James Raiford (San Francisco, California); Jason King (San Francisco, California); Becca Suchower (Sausalito, California); Brian Atchley (Petaluma, California) |
| ABSTRACT | A system for controlling the position and orientation of a floating solar array, having: (a) a floating solar array; (b) a plurality of retractable, bi-directional thrusters mounted to the floating solar array and extending below the floating solar array; (c) a control system on the floating solar array for controlling power level of each of the plurality of thrusters, and (d) a power cable connecting the floating solar array to an onshore grid by way of a power cable connector at a bottom central location on the floating solar array. Submerged baffles, perimeter floats and a method of stowing the floating solar array in high winds by rotating the floating solar array into a direction perpendicular to the direction of the high winds are also included. |
| FILED | Tuesday, September 05, 2023 |
| APPL NO | 18/460965 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 7/082 (20130101) B63B 35/38 (20130101) B63B 35/44 (20130101) B63B 79/10 (20200101) B63B 2035/4453 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) H02J 2300/24 (20200101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/40 (20141201) Original (OR) Class H02S 40/32 (20141201) H02S 40/38 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184669 | Razeghi-Jahromi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ABB Schweiz AG (Baden, Switzerland) |
| ASSIGNEE(S) | ABB Schweiz AG (Baden, Switzerland) |
| INVENTOR(S) | Mohammad Razeghi-Jahromi (Cary, North Carolina); David Lee Coats (Apex, North Carolina); James D. Stoupis (Raleigh, North Carolina) |
| ABSTRACT | A method for determining whether a power system is encountering a malicious attack is provided. The method comprises: receiving a plurality of first phasor measurement unit (PMU) measurements from a plurality of PMUs of the power system; determining a plurality of expected PMU measurements associated with a future time period based on an optimization algorithm that uses differences between a plurality of consecutive predictive entries and the plurality of first PMU measurements; receiving, from the plurality of PMUs, a plurality of second PMU measurements associated with the future time period; determining whether the power system is encountering the malicious attack based on comparing the plurality of expected PMU measurements with the plurality of second PMU measurements; and executing an action based on whether the power system is encountering the malicious attack. |
| FILED | Wednesday, August 04, 2021 |
| APPL NO | 17/393767 |
| ART UNIT | 2119 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00002 (20200101) H02J 13/00016 (20200101) H02J 13/00032 (20200101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12185557 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (, None) |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Chan Ho Soh (Ann Arbor, Michigan) |
| ABSTRACT | An optoelectronic device comprises a first electrode; a first host material layer positioned over the first electrode; a second host material layer positioned over the first host material layer; at least one ultrathin dopant layer positioned between the first and second host material layers, the at least one ultrathin dopant layer having a thickness of less than 2 Å; and a second electrode positioned over the second host material layers. Other organic optoelectronic devices are also disclosed. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530817 |
| ART UNIT | 2899 — Semiconductors/Memory |
| CURRENT CPC | Organic electric solid-state devices H10K 30/865 (20230201) Original (OR) Class H10K 50/11 (20230201) H10K 50/15 (20230201) H10K 2102/351 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12185619 | Forrest |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | The Regents of the University of Michigan (, None) |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A method for fabricating an organic electronic device comprises providing a plurality of photoresist structures on a substrate, the substrate having a first electrode layer, the photoresist structures having a bottom surface attached to the substrate and a top surface opposite the bottom surface, the top surface having a dimension greater than a dimension of the bottom surface, positioning a mask over the structures, the mask having a plurality of openings, and depositing an emissive material over the substrate through at least one of the plurality of openings to form at least one emissive element. An organic electronic device and a method of fabricating an organic electronic component are also described. |
| FILED | Friday, October 20, 2023 |
| APPL NO | 18/491050 |
| ART UNIT | 2896 — Semiconductors/Memory |
| CURRENT CPC | Organic electric solid-state devices H10K 59/122 (20230201) H10K 71/166 (20230201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 12178509 | Alvarez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Tara Lynn Alvarez (Whippany, New Jersey); Chang Yaramothu (Fanwood, New Jersey); John Vito d'Antonio-Bertagnolli (Mount Laurel, New Jersey); Mitchell Scheiman (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Exemplary embodiments relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253300 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/005 (20130101) A61B 3/08 (20130101) Original (OR) Class A61B 3/032 (20130101) A61B 3/113 (20130101) A61B 5/7267 (20130101) Optical Elements, Systems, or Apparatus G02B 30/36 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178552 | Burnham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Huxley Medical, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | Huxley Medical, Inc. (Atlanta, Georgia) |
| INVENTOR(S) | Daniel Burnham (Atlanta, Georgia); Behnam Molavi (Redmond, Washington); Mohsen Safaei Mohammadabadi (Smyrna, Georgia); Pannaga Sameer Kaushik Gummuluru (Kennedale, Texas); Matias Teixeira Prates (Kennesaw, Georgia) |
| ABSTRACT | The present disclosure relates to systems and processes for optimizing the detection of a patient's heartbeats, which may be useful in detection of the patient's oxygen saturation, as well as systems and processes for improving and optimizing the PPG signal quality of those patients with highly pigmented skin. In various embodiments, the process may comprise the steps of: receiving, from a radio, red data, infrared (IR) data, and a series of heartbeats associated with a time period; computing a series of peaks of the red data and IR data for the time period; computing a subset of the red data and IR data; estimating an oxygen saturation percentage (SpO2%) for the patient by computing an optical ratio of the red data and IR data included in the subset; and displaying on a computer screen the estimated SpO2% for the patient. |
| FILED | Monday, April 15, 2024 |
| APPL NO | 18/636180 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02 (20130101) Original (OR) Class A61B 5/318 (20210101) A61B 5/1455 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178588 | Grover et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Pulkit Grover (Pittsburgh, Pennsylvania); Alireza Chamanzar (Pittsburgh, Pennsylvania); Marlene Behrmann Cohen (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel method for using the widely-used electroencephalography (EEG) systems to detect and localize silences in the brain is disclosed. The method detects the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. This method can also be used for reduced activity localization, activity level mapping throughout the brain, as well as mapping activity levels in different frequency bands. By accounting for the contributions of different sources to the power of the recorded signals and using a hemispheric baseline approach and a convex spectral clustering framework, the method permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data. |
| FILED | Thursday, January 11, 2024 |
| APPL NO | 18/410446 |
| ART UNIT | 3798 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/372 (20210101) Original (OR) Class A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178636 | Dagdeviren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Canan Dagdeviren (Cambridge, Massachusetts); Lin Zhang (Winchester, Massachusetts) |
| ABSTRACT | An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate. |
| FILED | Wednesday, August 30, 2023 |
| APPL NO | 18/458406 |
| ART UNIT | 3798 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/466 (20130101) A61B 8/0825 (20130101) Original (OR) Class A61B 8/4209 (20130101) A61B 8/4472 (20130101) A61B 8/4477 (20130101) A61B 8/4488 (20130101) A61B 8/5207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178886 | Achilefu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/449766 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12178891 | Bowers et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, INC. (Gainesville, Florida) |
| INVENTOR(S) | Clifford Russell Bowers (Gainesville, Florida); Wenbo Zhao (Cambridge, United Kingdom) |
| ABSTRACT | Methods of and systems for making a hyperpolarized fluid are provided, which include exposing a fluid and parahydrogen to a catalyst. The hyperpolarized fluid can be introduced to a subject. The hyperpolarized fluid can be included in methods of imaging a subject. Also provided are methods that use the hyperpolarized fluids for detecting protein ligand interactions and for enhancing the NMR signals of biopolymers having chemically exchangeable protons. |
| FILED | Friday, October 05, 2018 |
| APPL NO | 16/753875 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1824 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/088 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/282 (20130101) G01R 33/4608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179026 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Jacob Robinson (Houston, Texas); Fatima Alrashdan (Houston, Texas); Kaiyuan Yang (Houston, Texas); Zhanghao Yu (Houston, Texas); Joshua Woods (Houston, Texas); Amanda Singer (Houston, Texas); Matthew Parker (Houston, Texas) |
| ABSTRACT | Exemplary embodiments of this disclosure include apparatus, systems and methods utilizing a passive, power-efficient backscattering communication system that enables transmitting data wirelessly between implantable magnetoelectric (ME) devices and an external base station. Certain embodiments encode the transmitted data through modulating the resonance frequency of a ME film by digitally tuning its electric loading conditions. |
| FILED | Friday, June 16, 2023 |
| APPL NO | 18/336787 |
| ART UNIT | 3796 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3727 (20130101) A61N 1/3787 (20130101) A61N 1/36062 (20170801) A61N 1/37223 (20130101) Original (OR) Class A61N 1/37288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179194 | Shirwaiker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Rohan Shirwaiker (Raleigh, North Carolina); Parth Chansoria (Raleigh, North Carolina); Lokesh Narayanan (Raleigh, North Carolina) |
| ABSTRACT | Method of ultrasound-assisted 3D bioprinting includes depositing a bioink fluid matrix containing a suspension of cells into a chamber comprising two piezo transducers on opposing ends of the chamber. The method further includes vibrating the piezo transducers to generate longitudinal bulk acoustic waves within the bioink fluid matrix such that waves from opposing piezo transducers superimpose to form a standing bulk acoustic wave to drive the cells to cluster and align along one or more nodes or nodal planes formed within the bioink fluid matrix at points of intersection of the standing bulk acoustic wave. The nodes or nodal planes are spaced apart from each other by a distance equaling half a wavelength of the standing bulk acoustic wave. The nodes or nodal planes further mimic a contour of the vibrating surfaces of the piezo transducers. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207057 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2200/0668 (20130101) B01L 2400/0436 (20130101) B01L 2400/0439 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12179199 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Abraham P. Lee (Irvine, California); Xuan Li (Irvine, California) |
| ABSTRACT | A microfluidic device having an array for cell trapping is used to analyze cell-cell interaction at single-cell level. The microfluidic trapping array efficiently pairs single cells in isolated compartments in an easy-to-operate manner. A first cell is squeezed through an opening of a first cavity by a strong forward flow. Subsequently, a second cell is pushed into a second cavity by a low reverse flow. The trapped cell pairs are sealed by an oil phase or hydrogel into isolated compartments, thereby eliminating interference from other cell pairs or the surrounding media. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 16/988179 |
| ART UNIT | 1796 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0647 (20130101) B01L 2200/0668 (20130101) B01L 2300/0883 (20130101) B01L 2400/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180232 | Trovitch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ryan J. Trovitch (Phoenix, Arizona); Anuja Sharma (Mumbai, India); Thu Thao Nguyen (Mesa, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Ryan J. Trovitch (Phoenix, Arizona); Anuja Sharma (Mumbai, India); Thu Thao Nguyen (Mesa, Arizona) |
| ABSTRACT | Aryl diimine first row metal compounds are described, as well as their synthesis and use as catalysts for the hydrofunctionalization of unsaturated organic compounds and main group element-main group element bond formation by dehydrogenative coupling. |
| FILED | Tuesday, September 27, 2022 |
| APPL NO | 17/953546 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/00 (20130101) Original (OR) Class C07F 15/02 (20130101) C07F 15/04 (20130101) C07F 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180241 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Yu Tian (Tallahassee, Florida) |
| ABSTRACT | Metal halide perovskite crystals, composite materials that include metal halide perovskite crystals and a polymeric matrix material, devices that include metal halide perovskite crystals, and methods of forming metal halide perovskite crystals, composite materials, and devices. The devices may include optoelectronic devices, such as light-emitting diodes. The light-emitting diodes may emit red light. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380904 |
| ART UNIT | 1692 — Organic Chemistry |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/005 (20130101) C07F 7/003 (20130101) C07F 7/24 (20130101) Original (OR) Class Organic electric solid-state devices H10K 85/1135 (20230201) H10K 85/6572 (20230201) H10K 2102/103 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180249 | Raj et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Monika Raj (Atlanta, Georgia); Ogonna Nwajiobi (Decatur, Georgia) |
| ABSTRACT | This disclosure relates to compositions and methods for selective labeling of N-alkyl lysine, N-alkyl adenosine, proline, N-alkyl cytosine, peptides, nucleic acids, or aliphatic or aromatic secondary amines. In certain embodiments, this disclosure relates to methods of forming triazene labeled compounds comprising contacting a compound containing a secondary amine group with a compound comprising an aromatic group with a diazonium para substituted with an electron rich group under conditions such that a triazene labeled compound is formed at the secondary amine group. |
| FILED | Wednesday, September 21, 2022 |
| APPL NO | 17/933963 |
| ART UNIT | 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Heterocyclic Compounds C07D 233/88 (20130101) Peptides C07K 1/22 (20130101) C07K 1/1077 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180338 | Hernandez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATON, INC. (Ames, Iowa) |
| ASSIGNEE(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| INVENTOR(S) | Nacu Hernandez (Ames, Iowa); Mengguo Yan (San Jose, California); Eric William Cochran (Ames, Iowa); John Edward Matthiesen (Hillsboro, Oregon); Jean-Philippe Tessonnier (Ames, Iowa) |
| ABSTRACT | The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers. |
| FILED | Monday, April 01, 2024 |
| APPL NO | 18/623237 |
| ART UNIT | 1766 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/26 (20130101) C08G 69/28 (20130101) C08G 69/48 (20130101) C08G 69/265 (20130101) Original (OR) Class C08G 77/455 (20130101) C08G 81/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180485 | Wong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Wilson Wai Chun Wong (Brookline, Massachusetts); Yage Ding (Allston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy. |
| FILED | Thursday, December 15, 2022 |
| APPL NO | 18/066482 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1241 (20130101) C12N 15/63 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180507 | Khetani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (, None) |
| INVENTOR(S) | Salman R. Khetani (Chicago, Illinois); Mitchell J. Durham (Fort Collins, Colorado); Brenton R. Ware (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs. |
| FILED | Friday, August 05, 2016 |
| APPL NO | 15/749733 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/44 (20130101) A61K 35/407 (20130101) A61K 35/407 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2502/1323 (20130101) C12N 2503/02 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) C12N 2535/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180534 | Xuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Xuan (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts); Mingjie Dai (Cambridge, Massachusetts); Xi Chen (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523611 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6804 (20130101) C12Q 2525/186 (20130101) C12Q 2525/301 (20130101) C12Q 2531/119 (20130101) C12Q 2565/514 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 70/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180536 | Seelig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Tuesday, December 12, 2023 |
| APPL NO | 18/536766 |
| ART UNIT | 1684 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 1/6855 (20130101) C12Q 2563/179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181540 | Jaroszynski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| INVENTOR(S) | Jan J. Jaroszynski (Tallahassee, Florida); George Miller (Tallahassee, Florida); David Larbalestier (Tallahassee, Florida); Anca-Monia Constantinescu (Tallahassee, Florida) |
| ABSTRACT | This disclosure presents systems, devices, and methods that use magnetometers to measure large magnetic moments with strong magnetic anisotropy. A torque magnetometer may include an actuator driven by a motor, a load cell coupled to the actuator, a rotatable spool having a platform configured to hold a sample of a superconductor material, where the rotatable spool is coupled to the load cell by a first line, a pulley, and a second line extending between the rotatable spool and a counterweight, where the second line is positioned on the pulley. Movement of the actuator may cause the rotatable spool to rotate an angle of the platform relative to a magnetic field about the rotatable spool, and the load cell is capable of measuring the tension on the first line. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/804297 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/096 (20130101) Original (OR) Class Electric solid-state devices not otherwise provided for H10N 50/80 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12181772 | Feng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Liang Feng (Wynnewood, Pennsylvania); Han Zhao (Philadelphia, Pennsylvania) |
| ABSTRACT | An optical switch device and a related method for defining a topological light transport channel in a photonic lattice are provided. An exemplary optical switch device includes a photonic lattice including a photonic topological microring array comprising a plurality of site rings coupled via a plurality of anti-resonant link rings, a plurality of input light ports and a plurality of output light ports located at the plurality of site rings, wherein the plurality of input light ports and the plurality of output light ports are respectively connected by a plurality of topological light transport channels. The optical switch device is further configured such that each of the topological light transport channels is defined by a gain domain area that is produced by a corresponding patterned optical pumping beam emitted onto the photonic topological microring array. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/642396 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/313 (20130101) Original (OR) Class G02F 2202/102 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183574 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Jung-Woo Ted Seo (Naperville, Illinois); Jian Zhu (Tianjin, China PRC) |
| ABSTRACT | Printable inks based on a 2D semiconductor, such as MoS2, and its applications in fully inkjet-printed optoelectronic devices are disclosed. Specifically, percolating films of MoS2 nanosheets with superlative electrical conductivity (10−2 s m−1) are achieved by tailoring the ink formulation and curing conditions. Based on an ethyl cellulose dispersant, the MoS2 nanosheet ink also offers exceptional viscosity tunability, colloidal stability, and printability on both rigid and flexible substrates. Two distinct classes of photodetectors are fabricated based on the substrate and post-print curing method. While thermal annealing of printed devices on rigid glass substrates leads to a fast photoresponse of 150 μs, photonically annealed devices on flexible polyimide substrates possess high photoresponsivity exceeding 50 mA/W. The photonically annealed photodetector also significantly reduces the curing time down to the millisecond-scale and maintains functionality over 500 bending cycles, thus providing a direct pathway to roll-to-roll manufacturing of next-generation flexible optoelectronics. |
| FILED | Tuesday, October 17, 2023 |
| APPL NO | 18/380747 |
| ART UNIT | 2812 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02538 (20130101) Original (OR) Class H01L 21/02551 (20130101) H01L 21/02568 (20130101) H01L 21/02601 (20130101) H01L 21/02606 (20130101) H01L 31/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183811 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Vinod K. Sangwan (Evanston, Illinois); Hong-Sub Lee (Seongnam-si, South Korea) |
| ABSTRACT | A memtransistor includes a top gate electrode and a bottom gate electrode; a polycrystalline monolayer film formed of an atomically thin material disposed between the top gate electrode and the bottom gate electrode; and source and drain electrodes spatial-apart formed on the polycrystalline monolayer film to define a channel in the polycrystalline monolayer film between the source and drain electrodes. The top gate electrode and the bottom gate electrode are capacitively coupled with the channel. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/036428 |
| ART UNIT | 2891 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Static Stores G11C 13/004 (20130101) G11C 13/0069 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/127 (20130101) H01L 27/1225 (20130101) H01L 29/24 (20130101) H01L 29/0665 (20130101) H01L 29/685 (20130101) Original (OR) Class H01L 29/1033 (20130101) H01L 29/4908 (20130101) H01L 29/7394 (20130101) H01L 29/66969 (20130101) Electronic Memory Devices H10B 99/22 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183852 | Brueck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R. J. Brueck (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Christian Wetzel (Troy, New York); Mark Durniak (Troy, New York) |
| ABSTRACT | A method of forming a semiconductor structure includes providing a substrate comprising a first material portion and a single crystal silicon layer on the first material portion. The substrate further comprises a major front surface, a major backside surface opposing the major front surface, and a plurality of grooves positioned in the major front surface. A buffer layer is deposited in one or more of the plurality of grooves. A semiconductor material is epitaxially grown over the buffer layer and in the one or more plurality of grooves, the epitaxially grown semiconductor material comprising a hexagonal crystalline phase layer and a cubic crystalline phase structure disposed over the hexagonal crystalline phase. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208905 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0243 (20130101) H01L 21/0251 (20130101) H01L 21/0254 (20130101) H01L 21/02381 (20130101) H01L 21/02395 (20130101) H01L 21/02433 (20130101) H01L 21/02458 (20130101) H01L 21/02494 (20130101) H01L 21/02502 (20130101) H01L 21/02587 (20130101) H01L 21/02609 (20130101) H01L 21/7806 (20130101) H01L 29/04 (20130101) H01L 33/04 (20130101) H01L 33/18 (20130101) H01L 33/32 (20130101) Original (OR) Class H01L 33/0075 (20130101) H01L 33/0093 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183901 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORIA (Oakland, California) |
| INVENTOR(S) | Zheng Chen (San Diego, California); Xiaolu Yu (La Jolla, California) |
| ABSTRACT | A process for low temperature hydrothermal relithiation of spent lithium-ion battery cathode materials adds a reducing agent to an aqueous Li solution at 80-100° C. followed by a short anneal to achieve complete recovery of composition, crystal structure, and electrochemical performance for heavily degraded cathode materials. |
| FILED | Wednesday, August 21, 2024 |
| APPL NO | 18/811672 |
| ART UNIT | 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184244 | Bameri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hadi Bameri (Davis, California); Omeed Momeni (Davis, California) |
| ABSTRACT | A power amplifier (amp) is disclosed. This power amp can include a first transistor configured in the common source (CS) amplification mode, wherein the gate terminal of the first transistor is used as the input port of the power amp; and a second transistor configured in the common gate (CG) amplification mode, wherein the drain terminal of the second transistor is used as the output port of the power amp. The power amp also includes a first inductive component coupled between the drain terminal of the first transistor and the ground to increase the impedance between the drain terminal of the first transistor and the ground, thereby increasing an output power at the output port. The power amp additionally includes a second inductive component coupled between the drain terminal of the first transistor and the source terminal of the second transistor to increase the conductance in the output admittance at the output port, thereby further increasing the output power at the output port. |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 17/369879 |
| ART UNIT | 2843 — Electrical Circuits and Systems |
| CURRENT CPC | Amplifiers H03F 3/211 (20130101) Original (OR) Class H03F 2200/451 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184259 | Lekavicius et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Ignas Lekavicius (Eugene, Oregon); Hailin Wang (Eugene, Oregon) |
| ABSTRACT | A back side of a diamond or other substrate is thinned using plasma etches and a mask situated away from the back side by a spacer having a thickness between 50 μm and 250 μm. Typically, a combined RIE/ICP etch is used to thin the substrate from 20-40 μm to less than 1 μm. For applications in which color centers are implanted or otherwise situated on a front side of the diamond substrate, after thinning, a soft graded etch is applied to reduce color center linewidth, particularly for nitrogen vacancy (NV) color centers. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466979 |
| ART UNIT | 1716 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0042 (20130101) G03F 7/2035 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/02055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 12178170 | Takeda |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia) |
| INVENTOR(S) | Fumiomi Takeda (Scotsdale, Arizona) |
| ABSTRACT | A strawberry treatment platform includes an outer housing with at least one UV-C light array enclosed in the outer housing, and at least one strawberry plant manipulating assembly that extends downwardly from the outer housing. The strawberry treatment platform is structured so that, as the strawberry treatment platform moves across a strawberry plant bed, the plant manipulating assembly combs through the strawberry plants and creates a canopy gap in the strawberry bed plant canopy so that radiation from the UV-C light array treats the strawberry plants in the strawberry plant bed. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825720 |
| ART UNIT | 3642 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/045 (20130101) A01G 9/249 (20190501) Original (OR) Class A01G 22/05 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180462 | Talaat |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Adel M. Talaat (Madison, Wisconsin) |
| ABSTRACT | Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine. |
| FILED | Friday, May 19, 2023 |
| APPL NO | 18/320834 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) A61K 2039/522 (20130101) A61K 2039/552 (20130101) Peptides C07K 14/35 (20130101) C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 1/36 (20130101) C12N 1/205 (20210501) C12N 15/1031 (20130101) C12N 15/1136 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 2600/156 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/32 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180523 | Tholl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| INVENTOR(S) | Dorothea Tholl (Blacksburg, Virginia); Jason Lancaster (Blacksburg, Virginia) |
| ABSTRACT | Described herein are engineered polynucleotides and vectors capable of encoding one or more engineered southern green stink bug pheromone synthesis enzymes. Also described herein are engineered southern green stink bug pheromone synthesis enzymes. Also described herein are methods of making modified plants capable of expressing one or more southern green stink bug pheromone synthesis enzymes. |
| FILED | Saturday, September 28, 2019 |
| APPL NO | 17/291604 |
| ART UNIT | 1662 — Plants |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 12183811 | Hersam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| INVENTOR(S) | Mark C. Hersam (Wilmette, Illinois); Vinod K. Sangwan (Evanston, Illinois); Hong-Sub Lee (Seongnam-si, South Korea) |
| ABSTRACT | A memtransistor includes a top gate electrode and a bottom gate electrode; a polycrystalline monolayer film formed of an atomically thin material disposed between the top gate electrode and the bottom gate electrode; and source and drain electrodes spatial-apart formed on the polycrystalline monolayer film to define a channel in the polycrystalline monolayer film between the source and drain electrodes. The top gate electrode and the bottom gate electrode are capacitively coupled with the channel. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/036428 |
| ART UNIT | 2891 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Static Stores G11C 13/004 (20130101) G11C 13/0069 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/127 (20130101) H01L 27/1225 (20130101) H01L 29/24 (20130101) H01L 29/0665 (20130101) H01L 29/685 (20130101) Original (OR) Class H01L 29/1033 (20130101) H01L 29/4908 (20130101) H01L 29/7394 (20130101) H01L 29/66969 (20130101) Electronic Memory Devices H10B 99/22 (20230201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184832 | Rzhanov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of New Hampshire (Durham, New Hampshire) |
| ASSIGNEE(S) | University of New Hampshire (Durham, New Hampshire) |
| INVENTOR(S) | Yuri Rzhanov (Durham, New Hampshire) |
| ABSTRACT | A system and method for colorimetric calibration is described herein. A system for performing color calibration is described, comprising at least one broad spectrum light emitting diode, at least one light diffuser plate, at least one interference filter, and a camera, the camera comprising at least one sensor for detection of colors, wherein a spectral response within 5% error of a ground truth method can be achieved. A method for performing color calibration is described, comprising transmitting light from at least one broad spectrum light emitting diode, scattering light with at least one light diffuser plate, filtering light with at least one interference filter, detecting light at a camera sensor, mapping an intensity value for each pixel of the camera sensor, and creating a quantum efficiency curve for each of red, green, and blue channels. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518105 |
| ART UNIT | 2422 — Cable and Television |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/28 (20130101) Pictorial Communication, e.g Television H04N 17/002 (20130101) H04N 17/02 (20130101) Original (OR) Class H04N 23/84 (20230101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 12181603 | Mosier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Bruce P. Mosier (Baltimore, Maryland); Lee S. Stearns (Laurel, Maryland); Daniel D. Winker (Columbia, Maryland); Nicolas Norena Acosta (Silver Spring, Maryland) |
| ABSTRACT | A detector may include processing circuitry configured to receive monitoring data associated with an environment being monitored, where the monitoring data includes a series of frames of three-dimensional point cloud information. The processing circuitry may be further configured to perform image segmentation on the monitoring data to generate segmented three-dimensional data associated with the environment, identify one or more objects in the environment based on subtracting background from the segmented three-dimensional data, convert data associated with the one or more objects from the segmented three-dimensional data into two-dimensional object data, and perform object classification on the two-dimensional object data. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206577 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4802 (20130101) Original (OR) Class G01S 17/42 (20130101) G01S 17/89 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/181 (20130101) G08B 29/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12183081 | Fortune et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Fortune (Clifton, Virginia); Brian Lewis (Washington, District of Columbia); Michelle Weinberger (Fairfax City, Virginia) |
| ABSTRACT | An example method to characterize an anomaly includes obtaining information about an item using a first mode scan and detecting whether the item contains an anomaly based on the information. The method further includes determining, responsive to detecting the anomaly, an area of interest of the item corresponding to a location of the anomaly, and determining a strategy including a procedure to obtain other information of the area of interest. The method refines a characterization of the anomaly based on the other information, and compares the characterization of the anomaly to a predetermined criterion. The method iteratively revises the strategy to perform additional available procedures, to further refine the characterization of the anomaly. When the characterization of the anomaly meets the predetermined criterion corresponding to a prohibited item, the method identifies the anomaly as prohibited. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353320 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/10 (20130101) Electric Digital Data Processing G06F 18/22 (20230101) G06F 18/251 (20230101) Image Data Processing or Generation, in General G06T 7/30 (20170101) G06T 7/70 (20170101) G06T 2207/10116 (20130101) G06T 2207/30232 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 20/52 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 12181985 | Goodloe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Colby Goodloe (Greenbelt, Maryland); Luis Santos Soto (Wallops Island, Virginia); Charles Clagett (Greenbelt, Maryland); David Everett (Greenbelt, Maryland) |
| ABSTRACT | A spacecraft computing system, including: a first processor configured to process data from a payload and a first spacecraft system; a second processor configured to process data from a second spacecraft system; an interface connected to the second processor configured to interface with a third spacecraft system, wherein the second processor is configured to monitor the first processor and to initiate the recovery of the first processor when the first processor experiences a fault, wherein the first processor's processing capacity is greater the second processor's processing capacity, and wherein the second processor is more reliable than the first processor. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159338 |
| ART UNIT | 2114 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 3/00 (20130101) Electric Digital Data Processing G06F 11/2028 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184394 | Bode et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Atlas Space Operations, Inc. (Traverse City, Michigan) |
| ASSIGNEE(S) | Atlas Space Operations, Inc. (Traverse City, Michigan) |
| INVENTOR(S) | Brad Arnold Bode (Pacific Palisades, California); Kyle Stephen Polich (Los Angeles, California) |
| ABSTRACT | The present application relates to techniques for proactively monitoring and detecting failures associated with downlinking data during satellite passes. In some embodiments, first data representing a performance of a hardware device during a satellite pass may be obtained and performance metrics may be computed based on the first data. Second data may be generated based on the performance metrics and a first machine learning model may be used to determine changepoints within the second data and times associated with each changepoint. A second machine learning model may be used to determine a likelihood that the satellite pass will be successful based on at least one of the quantity of changepoints or the times associated with each changepoint, and a quality of service (QoS) score of a client may be updated based on the likelihood. |
| FILED | Tuesday, August 01, 2023 |
| APPL NO | 18/363583 |
| ART UNIT | 2468 — Multiplex and VoIP |
| CURRENT CPC | Transmission H04B 7/18517 (20130101) H04B 7/18519 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 12179907 | Birch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Orbital Research Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | Orbital Research Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Matthew C. Birch (Madison, Alabama); Zak Sowle (Bellbrook, Ohio) |
| ABSTRACT | Multiple redundant harmonic drive motors on a rotor head actuate the angle of attack of rotor blades at the rotor blade roots, providing collective control that, in combination with a system for providing cyclic control on the rotor blades, eliminates the need for a swashplate, thereby advantageously reducing the weight and maintenance cost of a helicopter, increasing its reliability, and reducing its vulnerability to ballistic attack. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/861698 |
| ART UNIT | 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/06 (20130101) B64C 11/30 (20130101) Original (OR) Class B64C 27/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12180301 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IMCARE BIOTECH, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | ImCare Biotech, LLC (Doylestown, Pennsylvania) |
| INVENTOR(S) | Xuanyong Lu (Horsham, Pennsylvania); Felix Lu (Woodland Hills, California) |
| ABSTRACT | Anti-AS-SPIK antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to diagnose disorders characterized by the expression of AS-SPIK (e.g., liver cancer). Diagnostic methods and kits comprising the anti-AS-SPIK antibodies are also disclosed. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/978634 |
| ART UNIT | 1677 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 16/38 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/32 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/567 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/57438 (20130101) G01N 2800/50 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 12181333 | Arcari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Service (Washington, District of Columbia) |
| INVENTOR(S) | Lisa Helene Arcari (Washington, District of Columbia); William Douglas Hallahan (Fredericksburg, Virginia) |
| ABSTRACT | Methods and systems are provided for rating quality of a scale within a plurality of scales. A method of determining a quality rating may include weighing a package on a scale, weighing the first package on a plurality of other scales, and comparing the weight of the package on the scale with the weight of the package on the plurality of other scales. The more agreement between the weight of the package on the scale with the weight of the package on the plurality of other scales, the higher the quality rating of the scale. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 16/403302 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Weighing G01G 23/01 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) G06Q 30/018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12182758 | Bornitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | United States Postal Services (Washington, District of Columbia) |
| INVENTOR(S) | Carrie Ann Bornitz (Sioux Falls, South Dakota); Robert E. Dixon, Jr. (Haymarket, Virginia); Ryan M. Luckay (Vienna, Virginia) |
| ABSTRACT | Systems and methods of creating, managing, and distributing supplemental content associated with items in a distribution network. A physical delivery item can be imaged and associated with additional content generated or associated with the sender of the physical delivery item. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495197 |
| ART UNIT | 3628 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 12178626 | Yeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Benjamin M. Yeh (Hillsborough, California); Yanjun Fu (San Francisco, California) |
| ABSTRACT | The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the encapsulated gas or partial vacuum particle contrast material into the bowel lumen with or without the deliver of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473590 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/03 (20130101) A61B 6/032 (20130101) A61B 6/481 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/484 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/50 (20130101) A61K 49/0419 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 12180093 | Yip et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Ngai Yin Yip (Summit, New Jersey); Chanhee Boo (Seoul, South Korea); Kinnari Shah (New York, New York); Ian Billinge (New York, New York); Robert Winton (Seattle, Washington); Eliza Dach (New York, New York) |
| ABSTRACT | Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated. Because these systems and methods do not require a phase change of water, these products are achieved with significantly higher energy efficiencies when compared to evaporation-based thermal methods. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348139 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/042 (20130101) C02F 1/66 (20130101) C02F 1/265 (20130101) Original (OR) Class C02F 1/444 (20130101) C02F 2103/08 (20130101) C02F 2103/10 (20130101) C02F 2209/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 12183838 | Delaunay |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL LABORATORIES, LLC. (Malibu, California) |
| ASSIGNEE(S) | HRL LABORATORIES, LLC (Malibu, California) |
| INVENTOR(S) | Pierre-Yves Delaunay (Santa Monica, California) |
| ABSTRACT | An infrared detector and a method for manufacturing it are disclosed. The infrared detector contains an absorber layer responsive to infrared light, a barrier layer disposed on the absorber layer, a plurality of contact structures disposed on the barrier layer; and an oxide layer disposed above the barrier layer and between the plurality of the contact structures, wherein the oxide layer reduces the dark current in the infrared detector. The method disclosed teaches how to manufacture the infrared detector. |
| FILED | Thursday, October 19, 2023 |
| APPL NO | 18/490456 |
| ART UNIT | 2893 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/0216 (20130101) Original (OR) Class H01L 31/0224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 12184364 | Robinson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rampart Communications, Inc. (Linthicum Heights, Maryland) |
| ASSIGNEE(S) | Rampart Communications, Inc. (Linthicum Heights, Maryland) |
| INVENTOR(S) | Matthew Brandon Robinson (Millersville, Maryland) |
| ABSTRACT | An apparatus includes a first communication device with multiple antennas, operably coupled to a processor and configured to access a codebook of transformation matrices. The processor generates a set of symbols based on an incoming data, and applies a permutation to each of the symbols to produce a set of permuted symbols. The processor transforms each of the permuted symbols based on at least one primitive transformation matrix, to produce a set of transformed symbols. The processor applies, to each of the transformed symbols, a precode matrix selected from the codebook of transformation matrices to produce a set of precoded symbols. The codebook of transformation matrices is accessible to a second communication device. The processor sends a signal to cause transmission, to the second communication device, of multiple signals, each representing a precoded symbol from the set of precoded symbols, each of the signals transmitted using a unique antenna from the plurality of antennas. |
| FILED | Thursday, October 26, 2023 |
| APPL NO | 18/495671 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Transmission H04B 7/0456 (20130101) Original (OR) Class H04B 7/0491 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, December 31, 2024.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20241231.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page