FedInvent™ Patents
Patent Details for Tuesday, January 24, 2006
This page was updated on Sunday, March 26, 2023 at 08:00 PM GMT
Department of Health and Human Services (HHS)
| US 06989129 | Licklider et al. |
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| ASSIGNEE(S) | The President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Lawrence J. Licklider (Jamaica Plain, Massachusetts); Steven P. Gygi (Foxboro, Massachusetts); Junmin Peng (Brighton, Massachusetts) |
| ABSTRACT | A system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration trapping column and a chromatography separation column terminating at an electrospray nozzle of an online mass spectrometer. The analysis column consists of a capillary having an inside diameter of between 75 and 125 microns packed throughout with a porous bed of micron particles. A branch outlet positioned 10 to 16 centimeters upstream from the nozzle divides the analysis column into an upstream pre-concentration trap and a downstream separation column. An autosampler delivers low volume liquid samples to the upstream inlet via a two-position valve. Feed connections couple the autosampler to upstream inlet when the valve is open to inject a liquid sample into the pre-concentration trap at a maximum loading flow rate in the range from 0.5 to 50 microliters/minute. Thereafter, when the valve closes, it terminates the further injection the sample, and a concentrated portion of the sample then passes though the chromatography separation column at a much slower flow rate between 10 and 1,000 nanoliters per minute. Throughput can be doubled by coupling two such analysis columns to a single autosampler using a ten-port, two position valve. A single column can be supplied through a six port two-position valve. |
| FILED | Thursday, April 04, 2002 |
| APPL NO | 10/115692 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing 422/70 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989146 | Albani et al. |
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| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Salvatore Albani (Encinitas, California); Berent J. Prakken (Pieter Saenredamstraat, Netherlands) |
| ABSTRACT | Provided are HLA pan DR peptides and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response. |
| FILED | Friday, April 06, 2001 |
| APPL NO | 09/828574 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 424/185.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989237 | Fulwyler et al. |
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| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Mack J. Fulwyler (Sarasota, Florida); Joe W. Gray (San Francisco, California) |
| ABSTRACT | The invention provides methods and devices for detecting the presence of one or more target analytes in a sample employing a channel having affixed therein one or more binding partners for each target analyte. Assays are carried out by transporting the sample through the channel to each successive binding partner so that target analyte present in said sample binds to the corresponding binding partner. The sample is then transported beyond the binding partner(s), followed by detection of any target analyte bound to each binding partner. In one embodiment, binding efficiency is increased by the use of segmented transport, wherein a first bolus or bubble of a fluid that is immiscible with the sample precedes the sample during transport and a second bolus or bubble of a fluid that is immiscible with the sample follows the sample. Many configurations are possible for the device of the invention. A preferred device includes: a substrate with a channel formed in its surface, and a cover element that overlies and seals the channel. Binding partner(s) are affixed to the surface of the cover element facing the channel lumen. |
| FILED | Wednesday, October 06, 2004 |
| APPL NO | 10/960224 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/7.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989245 | Huang |
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| ASSIGNEE(S) | The Burnham Institute (La Jolla, California) |
| INVENTOR(S) | Shi Huang (San Diego, California) |
| ABSTRACT | The invention provides a method of screening for a compound that modulates RIZ histone methyltransferase (HMT) activity, by contacting a RIZ or RIZ fragment having HMT activity with one or more candidate compounds, and determining histone methyltransferase activity of the contacted RIZ or RIZ fragment. Also provided is a method of screening for a compound that modulates progesterone receptor (PR) activity, by providing a RIZ1 modulatory compound, and determining the ability of the RIZ1 modulatory compound to modulate PR activity. Further provided is a method of identifying an individual with an estrogen receptor positive (ER+) tumor having a reduced likelihood of responding to endocrine therapy. The method involves determining the RIZ1 status of the tumor, wherein an abnormal RIZ1 status identifies the individual as an individual with a reduced likelihood of responding to endocrine therapy. |
| FILED | Thursday, May 09, 2002 |
| APPL NO | 10/142650 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/15 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989248 | Longley |
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| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | B. Jack Longley (Hamden, Connecticut) |
| ABSTRACT | This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a methods of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception. |
| FILED | Wednesday, December 29, 1999 |
| APPL NO | 09/474478 |
| ART UNIT | 1655 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/69.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989254 | Wei et al. |
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| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Yen Wei (Plainsboro, New Jersey); Jigeng Xu (Philadelphia, Pennsylvania); Hua Dong (Philadelphia, Pennsylvania); Qiuwei Feng (Morrisville, Pennsylvania) |
| ABSTRACT | Biomacromolecules encapsulated or immobilized within mesoporous or nanoporous materials via surfactant-templated sol-gel reactions and methods for production of these encapsulated or immobilized biomacromolecules are provided. |
| FILED | Tuesday, July 31, 2001 |
| APPL NO | 10/332423 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/176 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989256 | Peltz et al. |
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| ASSIGNEE(S) | University of Medicine and Dentistry of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Stuart Peltz (Piscataway, New Jersey); Kevin Czaplinski (Somerset, New Jersey); Jonathan D. Dinman (North Brunswick, New Jersey) |
| ABSTRACT | An isolated multiprotein complex of S. cerevisiae components is provided that is effective to modulate peptidyl transferase activity during translation. This complex includes a Modulator of Translation Termination protein (Mtt1p, also referred to as helicase B), a Upf1 protein, a peptidyl eukaryotic release factor 1 (eRF1) and a peptidyl eukaryotic release factor 3 (eRF3). |
| FILED | Thursday, August 28, 2003 |
| APPL NO | 10/652334 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/183 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989261 | Watkins et al. |
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| ASSIGNEE(S) | Eli Lilly and Company (Indianapolis, Indiana) |
| INVENTOR(S) | Jeffry D. Watkins (Encinitas, California); James D. Pancook (San Diego, California) |
| ABSTRACT | The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant. |
| FILED | Friday, April 11, 2003 |
| APPL NO | 10/413432 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/196 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989263 | Henderson et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Louis E. Henderson (Mt. Airy, Maryland); Larry O. Arthur (Walkersville, Maryland); William G. Rice (Frederick, Maryland) |
| ABSTRACT | The present invention provides several classes of compounds which can be used to inactivate retroviruses, such as HIV-1, by attacking the CCHC zinc fingers of the viral nucleocapsid protein and ejecting the zinc therefrom. In addition, kits for identifying compounds that can react with CCHC zinc fingers of the nucleocapsid proteins of a large number of different retroviruses have also been developed. The kits of the present invention describe a set of specific tests and reagents that can be used to screen and identify compounds based on their ability to react with and disrupt retroviral zinc fingers in the viral NC proteins and, in turn, inactivate the retrovirus of interest. |
| FILED | Monday, November 01, 1999 |
| APPL NO | 09/431607 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/236 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989264 | Atkinson et al. |
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| ASSIGNEE(S) | Targeted Genetics Corporation (Seattle, Washington) |
| INVENTOR(S) | Edward M. Atkinson (Indianapolis, Indiana); Ian L. Aranha (Seattle, Washington); Victor P. Fung (Redmond, Washington); Perry C. Wilkins (Preston, Washington); Ryan K. Takeya (Preston, Washington); Thomas C. Reynolds (Mercer Island, Washington) |
| ABSTRACT | This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication. |
| FILED | Tuesday, October 30, 2001 |
| APPL NO | 10/016767 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/239 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989265 | Blattner et al. |
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| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Frederick R. Blattner (Madison, Wisconsin); Gyorgy Posfai (Szeged, Hungary); Christopher D. Herring (Madison, Wisconsin); Guy Plunkett, III (Madison, Wisconsin); Jeremy D. Glasner (Madison, Wisconsin) |
| ABSTRACT | The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to 14% smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences from a bacterial genome. The methods provide precise deletions and seldom introduces mutations to the genomic DNA sequences around the deletion sites. Thus, the methods can be used to generate a series of deletions in a bacterium without increasing the possibility of undesired homologous recombination within the genome. In addition, some of the methods provided by the present invention can also be used for replacing a region of a bacterial genome with a desired DNA sequence. |
| FILED | Wednesday, January 23, 2002 |
| APPL NO | 10/057582 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/252.800 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989275 | Waggoner |
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| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Alan S. Waggoner (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type dyes that contain or are derivatized to contain a reactive group. The reactive group is covalently reactive with amine, hydroxy and/or sulfhydryl groups on the component so that the dye can be covalently bound to the component. In addition, the dyes are preferably soluble in aqueous or other medium in which the component is contained. The components to be labeled can be either biological materials, such as antibodies, antigens, peptides, nucleotides, hormones, drugs, or non-biological materials, such as polymers, glass, or other surfaces. Any luminescent or light absorbing detecting step can be employed in the method of the invention. |
| FILED | Friday, March 22, 2002 |
| APPL NO | 10/103119 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/501 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989362 | Bibb et al. |
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| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | James A. Bibb (New York, New York); Paul Greengard (New York, New York) |
| ABSTRACT | The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5 catalyzed phosphorylation of DARPP-32 converts this protein into an inhibitor of the cAMP dependent protein kinase (PKA) and furthermore prevents it from being converted to an inhibitor of protein phosphatase 1 (PP1). Methods of identifying agents that modulate the phosphorylation of DARPP-32 by Cdk5 are disclosed. Methods of treating dopamine dysfunction in animal subjects are also provided. |
| FILED | Friday, October 13, 2000 |
| APPL NO | 09/687959 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/1 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989375 | Cristiano et al. |
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| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Richard J. Cristiano (Pearland, Texas); Dao Nguyen (Potamac, Maryland) |
| ABSTRACT | The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the expression of the transgene is improved up to about 3-fold over the expression seen in the absence of the DNA-damaging agent treatment. This effect is not dependent on the tumor cell type, the method of DNA transduction or type of DNA-damaging agent. The effect is most dramatic when the transduction is performed about 1-3 days following treatment with the DNA-damaging agent. |
| FILED | Friday, August 03, 2001 |
| APPL NO | 09/922490 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/44 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989376 | Watkins et al. |
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| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Carol Watkins (Cambridge, Massachusetts); Richard J. Wurtman (Boston, Massachusetts) |
| ABSTRACT | Methods of treating certain neurological diseases using exogenous uridine or a uridine source alone as a precursor of endogenous cytidine, particularly in the human brain, are disclosed. Methods are also disclosed wherein exogenous uridine or a uridine source is combined either with drugs increasing uridine availability or with compounds that serve as a source of choline in phospholipid synthesis. |
| FILED | Friday, July 30, 1999 |
| APPL NO | 09/363748 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/50 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989377 | Hayes et al. |
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| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Colleen E. Hayes (Madison, Wisconsin); Faye E. Nashold (Sun Prairie, Wisconsin) |
| ABSTRACT | The present invention relates to therapeutics for the prevention and treatment of vitamin D responsive diseases in humans, as well as other animals, through the use of biologically active vitamin D compounds in combination with at least one other immunomodulatory compound such as interleukin-10, interleukin-4, or a TNFα inhibitor. |
| FILED | Thursday, June 13, 2002 |
| APPL NO | 10/170746 |
| ART UNIT | 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/167 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989386 | Rosowsky et al. |
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| ASSIGNEE(S) | Dana-Farber Cancer Institute (Boston, Massachusetts); Ash Stevens, Inc. (Detroit, Michigan) |
| INVENTOR(S) | Andre Rosowsky (Needham, Massachusetts); Henry Bader (Canton, Massachusetts); Peter Blumbergs (Royal Oak, Michigan); Ming-The Lin (Farmington Hills, Michigan) |
| ABSTRACT | In one embodiment, the present invention relates to a new class of ammonium salts of Nδ-acyl derivatives of Nα-(4-amino-4-deoxypteroyl)-L-ornithine compounds having a structure according to formula II-IV. Formula II has the structure of: wherein: R2 represents up to four groups independently selected at each occurrence of R2 from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C1-6 alkoxy, chloro, fluoro, hydroxy, and —COOH; R3, R4, and R5 are each independently selected from hydrogen and C1-6 alkyl; or NR3R4 taken combination can form a 5 to 7 member heterocycle having at least one nitrogen ring atom; and x is a real number greater than 0 and less than about 4. The ammonium salts provided by the invention exhibit high inhibitory activity against the growth o methotrexate-resistant cells, and also exhibit superior chemical stability than corresponding acidic Nδ-acyl derivatives of Nδ-acyl derivatives of Nα(4-amino-4-deoxypteroyl)-L-ornithine compounds. |
| FILED | Monday, April 14, 2003 |
| APPL NO | 10/412279 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/262.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989387 | LaVoie et al. |
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| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Edmond J. LaVoie (Princeton Junction, New Jersey); Sudhir K. Singh (Bangalore, India); Leroy F. Liu (Bridgewater, New Jersey) |
| ABSTRACT | The invention provides compounds of formula I: wherein R1–R9, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I. |
| FILED | Monday, August 11, 2003 |
| APPL NO | 10/638944 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/280 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989396 | Kinghorn et al. |
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| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | A. Douglas Kinghorn (Chicago, Illinois); John M. Pezzuto (River Forest, Illinois); Baoliang Cui (Palisades Park, New Jersey); Gloria L. Silva (Cordoba, Argentina); Min You (Indianapolis, Indiana) |
| ABSTRACT | Compounds and methods of modulating the activity of P-glycoproteins are disclosed. The method utilizes compounds derived from Erythroxylum pervillei. The compounds overcome multidrug resistance and can be used therapeutically to enhance performance of therapeutic drugs, like chemotherapeutic drugs and antibiotics. |
| FILED | Wednesday, April 10, 2002 |
| APPL NO | 10/119874 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/350 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990167 | Chen |
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| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Guang-Hong Chen (Madison, Wisconsin) |
| ABSTRACT | A new image reconstruction method is described for CT systems. Reconstruction formulas for general application to any CT system geometry are derived and more specific formulas for two third generation CT system geometries are described. A preferred embodiment of a CT system which employs one of the specific formulas is described. |
| FILED | Friday, August 29, 2003 |
| APPL NO | 10/651673 |
| ART UNIT | 2882 — Optics |
| CURRENT CPC | X-ray or gamma ray systems or devices 378/4 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990369 | Gandjbakhche et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Department of Health and Human Services (Washington, District of Columbia) |
| INVENTOR(S) | Amir H. Gandjbakhche (Potomac, Maryland); David W. Hattery (Washington, District of Columbia); Jim Mulshine (Bethesda, Maryland); Paul Smith (Annapolis, Maryland); Victor Chernomordik (Rockville, Maryland); Edward Wellner (Fairfax, Virginia) |
| ABSTRACT | The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases. |
| FILED | Wednesday, April 13, 2005 |
| APPL NO | 11/105180 |
| ART UNIT | 3737 — Dynamic Storage Systems; Mechanical parts of Disk Drives |
| CURRENT CPC | Surgery 6/477 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 06988394 | Shedd et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Tommy R. Shedd (Middletown, Maryland); Mark W. Widder (Chambersburg, Pennsylvania); Mark W. Brown (Myersville, Maryland); Murray S. Swanson (Rockyridge, Maryland) |
| ABSTRACT | A portable automated biomonitoring system for monitoring water quality includes an exposure chamber for housing an aquatic organism and a water inlet for directing water to the exposure chamber. The aquatic organism has ventilatory behavior and body movement sensitive to water quality. Electrodes sense electrical signals produced by the organism during its ventilatory behavior and body movement, and a controller responsive to signals from the electrodes determines a plurality of ventilatory parameters based on the signals. The ventilatory parameters are compared with corresponding thresholds to determine when the water to which the organism is exposed has caused physiological stress to the organism. The water being evaluated may be recirculated through the system for further analysis. |
| FILED | Tuesday, February 03, 2004 |
| APPL NO | 10/774639 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/61.410 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06988450 | Georgantzis et al. |
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| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Peter Georgantzis (East Stroudsburg, Pennsylvania); Keith J. Martin (Bangor, Pennsylvania); Andrew A. Molina (Stroudsburg, Pennsylvania); Andrew Gowarty (E. Stroudsburg, Pennsylvania); Anthony P. Farina (Hackettstown, New Jersey); Henry E. Hudgins (Lord's Valley, Pennsylvania) |
| ABSTRACT | Anti-personnel tank fired ammunition designed for attacking personnel at various ranges includes a hollow base member adapted with an electric primer and a plastic or aluminum canister containing a payload at one end thereof. In operation, the hollow cartridge is loaded with a solid propellant. The electric primer which is centrally located in the solid propellant is fired and provides a flash together with the gasses needed to ignite the propellant. The burning propellant then provides the gasses needed to force the canister from the gun tube in which the ammunition is positioned. |
| FILED | Monday, February 07, 2005 |
| APPL NO | 11/066360 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Ammunition and explosives 12/401 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06988540 | Jensen et al. |
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| ASSIGNEE(S) | Honeywell International Inc. (Morristown, New Jersey) |
| INVENTOR(S) | Joseph Mead Jensen (Torrance, California); Thomas Alexander Lee (Redondo Beach, California); Hai Truong Ly (Fullerton, California) |
| ABSTRACT | A heat exchanger for transferring energy from a second fluid to a first fluid has a plurality of tubes to carry one of the fluids and a layer of thermal buffer members on one side of the tubes to act as a buffer to reduce high thermal stresses that may be caused by global temperature patterns and localized high gradients that occur in system transients such as start up and shutdown. Conventional heat exchangers often have a short lifespan due to high thermal stresses acting on the core of the heat exchanger. The heat exchanger uses the thermal buffer members as an increased thermal mass to cause the temperature of the heat exchanger core to change in a more gradual manner, thereby reducing thermal stresses. |
| FILED | Thursday, October 30, 2003 |
| APPL NO | 10/698716 |
| ART UNIT | 3742 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Heat exchange 165/135 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989234 | Kolar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Pramod Kolar (Durham, North Carolina); Richard B. Fair (Durham, North Carolina) |
| ABSTRACT | An apparatus for actuating a droplet comprises a first conductive layer, a second conductive layer, a conductive elongate element, and a voltage source. The first conductive layer comprises a first hydrophobic surface. The second conductive layer comprises a hydrophilic surface facing the first hydrophobic surface. The second conductive layer is axially spaced from the first conductive layer to define a gap therebetween. The conductive medial element is disposed in the gap between the first and second conductive layers, and comprises a second hydrophobic surface. The voltage source communicates with the second conductive layer and the elongate element. By applying a voltage potential between the elongate element and the second conductive layer, droplets can be electrostatically actuated so as to move from the first conductive layer into contact with the second conductive layer. The apparatus is particularly useful in the synthesis of microarrays of biological, chemical, or biochemical samples. |
| FILED | Tuesday, September 24, 2002 |
| APPL NO | 10/253372 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/6 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989433 | Wong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Georgia Tech Research Corp. (Atlanta, Georgia) |
| INVENTOR(S) | Ching Ping Wong (Berkeley Lake, Georgia); Jiali Wu (Yorktown Heights, New York) |
| ABSTRACT | The present invention provides low stress non-hermetic conformal coatings for the protection of microelectronic devices, such as a Microelectromechanical system (MEMS) based multichip module from adverse environments. The induced stress from these two coatings due to the thermal cycling and manufacture processing will not cause any influence on sensing accuracy of the piezopressure sensor or similar functional MEMS devices. Furthermore, the conformal coatings have the merits of low glass transition temperature, good elongation, low moisture uptake and mobile ion permeation, room temperature curability and good contamination resistance to the jet fume, which promise a high reliability for the aerospace and avionics application. One conformal coating comprises a composition/formulation containing a rubber, siloxane or urethane oligomer modified epoxy and an organic hardener, and optionally an organic diluent and a curing catalyst. Another conformal coating comprises a composition/formulation containing a silicone elastomer or gel and a metal chelate catalyst, and optionally a silica filler, a diluent and an adhesion promoter or coupling agent. |
| FILED | Wednesday, May 08, 2002 |
| APPL NO | 10/141334 |
| ART UNIT | 1712 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Synthetic resins or natural rubbers 528/418 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989556 | Braddock |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Osemi, Inc. (Rochester, Minnesota) |
| INVENTOR(S) | Walter David Braddock (Rochester, Minnesota) |
| ABSTRACT | A self-aligned enhancement mode metal-oxide-compound semiconductor field effect transistor (10) includes a gate insulating structure comprised of a first oxide layer that includes a mixture of indium and gallium oxide compounds (30) positioned immediately on top of the compound semiconductor structure, and a second insulating layer comprised of either gallium oxygen and rare earth elements or gallium sulphur and rare earth elements positioned immediately on top of said first layer. Together the lower indium gallium oxide compound layer and the second insulating layer form a gate insulating structure. The gate insulating structure and underlying compound semiconductor layer (15) meet at an atomically abrupt interface at the surface of with the compound semiconductor wafer structure (14). The first oxide layer serves to passivate and protect the underlying compound semiconductor surface from the second insulating layer and atmospheric contamination. A refractory metal gate electrode layer (17) is positioned on upper surface (18) of the second insulating layer. The refractory metal is stable on the second insulating layer at elevated temperature. Self-aligned source and drain areas, and source and drain contacts (19, 20) are positioned on the source and drain areas (21, 22) of the device. Multiple devices are then positioned in proximity and the appropriate interconnection metal layers and insulators are utilized in concert with other passive circuit elements to form an integrated circuit structure. |
| FILED | Thursday, June 06, 2002 |
| APPL NO | 10/163506 |
| ART UNIT | 2813 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/192 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989575 | Gates et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Stephen M. Gates (Ossining, New York); Roy E. Scheuerlein (Cupertino, California) |
| ABSTRACT | Arrays of microelectronic elements such as magnetorestive memory elements and FET's, including dual-gate FET's, are fabricated by methods involving a host wafer and a first wafer on which part of the microelectronic elements are separately formed. Conductive elements such as metal-filled vias are formed in the host wafer and extend to its surface. Hydrogen ions are implanted at a selected depth in the first wafer. After formation of selected portions of the microelectronic elements above the hyrogen ion implantation depth of the first wafer, the latter is bonded to the surface of the host wafer so that complementary parts of the two wafers can join to form the microelectronic elements. The first wafer is fractured at the hydrogen ion implantation depth and its lower portion is removed to allow for polishing and affixing of electrodes thereon. |
| FILED | Monday, February 25, 2002 |
| APPL NO | 10/080568 |
| ART UNIT | 2814 — Semiconductors/Memory |
| CURRENT CPC | Active solid-state devices 257/421 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989730 | Leupold |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Herbert A. Leupold (Eatontown, New Jersey) |
| ABSTRACT | In accordance with an embodiment of the present invention, a permanent magnet, includes a body that has a body axis and that, in turn, has a plurality of discreet components. Each of the components may be radially spaced from the body axis approximately an equal distance and each component may be circumferentially spaced an approximately equal distance apart. Also, each of the components may include a cavity and a component axis and wherein each of the components may have an inner body, that, in turn, has a magnetic substance and that is rotatable about the component axis and a plurality of inner segments each having an inner segment magnetic field. The components may also include an outer body that, in turn, includes a magnetic substance and that is rotatable about the component axis. The outer body may also have a plurality of outer segments each having an outer segment magnetic field and the outer body being located in proximity to the inner body whereby each of the inner segment magnetic fields and the outer segment magnetic fields interact. |
| FILED | Tuesday, May 24, 2005 |
| APPL NO | 11/136761 |
| ART UNIT | 2832 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Magnetically operated switches, magnets, and electromagnets 335/306 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989749 | Mohr |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | John Anthony Mohr (Camarillo, California) |
| ABSTRACT | An electronic check out system which utilizes radio frequency check out devices to check out tools from a centrally located tool storage facility and to identify the individual checking out the tool. The electronic check out system includes readers located a tool boxes and the central storage facility exit to identify the tool and the user of the tool as well as the time and date the tool was removed from the storage facility. |
| FILED | Friday, November 21, 2003 |
| APPL NO | 10/718014 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Communications: Electrical 340/572.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989795 | Edward et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sensis Corporation (East Syracuse, New York) |
| INVENTOR(S) | Brian J. Edward (Jamesville, New York); John M. Marziale (Jamesville, New York); Peter J. Ruzicka (Auburn, New York) |
| ABSTRACT | A line-replaceable unit for a phased array antenna including a thermally conductive housing having a front face and an opposed rear face, at least one open-ended waveguide extending through the housing from the front face to the rear face, at least one first radiating element including the waveguide and adapted to emit energy in a first frequency band; and at least one second radiating element positioned on the front face of the housing and adapted to emit energy in a second frequency band distinct from the first frequency band. The waveguide is dimensioned to pass energy in the first frequency band and is exposed to the environment outside the housing at the front and rear faces to define a cooling duct passing through the housing. |
| FILED | Friday, July 23, 2004 |
| APPL NO | 10/897450 |
| ART UNIT | 2821 — Optical Communications |
| CURRENT CPC | Communications: Radio wave antennas 343/725 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989799 | Pittman, II |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | John Edward Pittman, II (Ashland, Massachusetts) |
| ABSTRACT | An antenna assembly including a first rotating pedestal including an antenna thereon, a second pedestal supporting the first pedestal, and a dual flow rotating union having a longitudinal axis. The dual flow rotating union includes a rotating housing portion coupled to the first rotating pedestal, a stationary housing portion coupled to the second stationary pedestal, and a conduit located in the housing portion. The conduit has opposing ports oriented parallel to the longitudinal axis, a rotating section and a stationary section. One said conduit port is located on the rotating section, and the other conduit port is located on the stationary section. The housing also has opposing ports oriented parallel to the longitudinal axis. One housing port is located on the stationary portion, and the other said housing port is located on the rotating portion. |
| FILED | Friday, September 24, 2004 |
| APPL NO | 10/949173 |
| ART UNIT | 2821 — Optical Communications |
| CURRENT CPC | Communications: Radio wave antennas 343/882 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989831 | Ebersole et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Information Decision Technologies, LLC (Bedford, New Hampshire) |
| INVENTOR(S) | John Franklin Ebersole (Bedford, New Hampshire); Todd Joseph Furlong (Manchester, New Hampshire); John Franklin Ebersole, Jr. (Bedford, New Hampshire) |
| ABSTRACT | Method and apparatus are presented for an augmented reality-based firefighter training system. The system includes hardware for motion tracking, display, and vari-nozzle instrumentation. System software includes a real-time fire model, a layered smoke obscuration model, simulation of an extinguishing agent, and an interface to a zone fire model. Physical modeling and graphical elements in the software combine to create realistic-looking fire, smoke, and extinguishing graphics. The hardware and software components together contribute to a realistic, interactive training experience for firefighters. |
| FILED | Tuesday, August 06, 2002 |
| APPL NO | 10/213338 |
| ART UNIT | 2671 — Optical Communications |
| CURRENT CPC | Computer graphics processing and selective visual display systems 345/420 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990239 | Nelson |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Susan Nelson (Panama City, Florida) |
| ABSTRACT | A method is provided for the detection and classification of targets in a digital image of a structure having known characteristics. In general, windowed portions of the image are evaluated in context with the entire image and in terms of their location in the image. More specifically, a scoring scheme is used to identify relevant windows with the relevance of each window being evaluated in terms of location in the image and the known characteristics of the structure being imaged. Relevant windows satisfying a threshold criteria are grouped based on their relative location in the image. A group scoring scheme is applied to each group to identify and classify targets. |
| FILED | Tuesday, July 16, 2002 |
| APPL NO | 10/197669 |
| ART UNIT | 2623 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/224 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990350 | Davis et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | University of Maryland (College Park, Maryland) |
| INVENTOR(S) | Christopher C. Davis (Bowie, Maryland); Stuart D. Milner (Potomac, Maryland); Igor I. Smolyaninov (Columbia, Maryland) |
| ABSTRACT | In a free space communication network in which different communication nodes are linked together by directed beams, a method for dynamically configuring the topology of the network allows the transmission directions of the communication nodes to be autonomously changed to communicate with a new node as dictated by the needs of the network. Moreover, the nodes can be switched from directional to broadcast and back again on an as-needed basis. The network consists of a topology that can be rapidly and physically reconfigured as required to provide multiple connectivity, a desired quality of service, or to compensate with the loss of communication links between nodes. The loss of direct communication between any two nodes in an optical network can occur because of obscuration of the atmospheric path between the two nodes. The directed beam which provides the communication channel between the two nodes can, in this situation, be steered to direct its energy towards another accessible node. |
| FILED | Wednesday, July 09, 2003 |
| APPL NO | 10/615182 |
| ART UNIT | 2683 — Telemetry and Code Generation Vehicles and System Alarms |
| CURRENT CPC | Telecommunications 455/452.200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990360 | Berger et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Henry Berger (Alexandria, Virginia); Edmundo Simental (Alexandria, Virginia) |
| ABSTRACT | A system, and method of its use, provides for detecting patterns that exist within a geographic area due to the presence of an orderly array of objects. In a preferred embodiment, the system uses an irregular array of transceivers to illuminate an area suspected of containing a minefield. Typically, these minefields are arranged in an orderly arrangement. Exploiting the Bragg Effect, the transceivers, each configured as a surface wave radar, illuminate an area with RF energy that is scanned in carrier frequency within the HF band (3–30 MHz) at a pre-specified interval. At the frequency that corresponds to the Bragg Effect, a significantly increased signal level occurs that indicates the presence of a pattern such as one might expect from reflections from numerous objects arranged orderly. By processing these returns judiciously, the minefield's size, location, perimeter, and even the location of individual mines may be determined. |
| FILED | Friday, November 02, 2001 |
| APPL NO | 09/985312 |
| ART UNIT | 2687 — Dynamic Storage Systems; Mechanical parts of Disk Drives |
| CURRENT CPC | Telecommunications 455/562.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 06988402 | Hasselbrink, Jr. et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Sandia National Laboratories (Livermore, California) |
| INVENTOR(S) | Ernest F. Hasselbrink, Jr. (Saline, Michigan); Jason E. Rehm (Alameda, California); Timothy J. Shepodd (Livermore, California); Brian J. Kirby (San Francisco, California) |
| ABSTRACT | A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine. |
| FILED | Thursday, September 04, 2003 |
| APPL NO | 10/655337 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/253 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06988415 | Richardson |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | John G. Richardson (Idaho Falls, Idaho) |
| ABSTRACT | A method and system for detecting, locating and quantifying a physical phenomena such as strain or a deformation in a structure. A minimum resolvable distance along the structure is selected and a quantity of laterally adjacent conductors is determined. Each conductor includes a plurality of segments coupled in series which define the minimum resolvable distance along the structure. When a deformation occurs, changes in the defined energy transmission characteristics along each conductor are compared to determine which segment contains the deformation. |
| FILED | Tuesday, September 09, 2003 |
| APPL NO | 10/658880 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring and testing 073/799 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989252 | Melis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Midwest Research Institute (Kansas City, Missouri) |
| INVENTOR(S) | Anastasios Melis (El Cerrito, California); Liping Zhang (Kensington, California); John R. Benemann (Walnut Creek, California); Marc Forestier (Lakewood, Colorado); Maria Ghirardi (Lakewood, Colorado); Michael Seibert (Lakewood, Colorado) |
| ABSTRACT | A reversible physiological process provides for the temporal separation of oxygen evolution and hydrogen production in a microorganism, which includes the steps of growing a culture of the microorganism in medium under illuminated conditions to accumulate an endogenous substrate, depleting from the medium a nutrient selected from the group consisting of sulfur, iron, and/or manganese, sealing the culture from atmospheric oxygen, incubating the culture in light whereby a rate of light-induced oxygen production is equal to or less than a rate of respiration, and collecting an evolved gas. The process is particularly useful to accomplish a sustained photobiological hydrogen gas production in cultures of microorganisms, such as Chlamydomonas reinhardtii. |
| FILED | Friday, December 22, 2000 |
| APPL NO | 09/748690 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemistry: Molecular biology and microbiology 435/168 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989276 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Vicki S. Thompson (Idaho Falls, Idaho); Karen B. Barrett (Meridian, Idaho); Diane E. Key (Idaho Falls, Idaho) |
| ABSTRACT | A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity. |
| FILED | Friday, December 14, 2001 |
| APPL NO | 10/017577 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemistry: Analytical and immunological testing 436/518 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989443 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| INVENTOR(S) | Haitao Wu (Wading River, New York); Michiko Miura (Hampton Bays, New York) |
| ABSTRACT | The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head, neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET. |
| FILED | Monday, June 28, 2004 |
| APPL NO | 10/878138 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Organic compounds 540/145 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989619 | Hsu |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | UT-Battelle LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | John S. Hsu (Oak Ridge, Tennessee) |
| ABSTRACT | A radial gap brushless electric machine (30) having a stator (31) and a rotor (32) and a main air gap (34) also has at least one stationary excitation coil (35a, 36a) separated from the rotor (32) by a secondary air gap (35e, 35f, 36e, 36f) so as to induce a secondary flux in the rotor (32) which controls a resultant flux in the main air gap (34). Permanent magnetic (PM) material (38) is disposed in spaces between the rotor pole portions (39) to inhibit the second flux from leaking from the pole portions (39) prior to reaching the main air gap (34). By selecting the direction of current in the stationary excitation coil (35a, 36a) both flux enhancement and flux weakening are provided for the main air gap (34). Improvements of a laminated rotor, an end pole structure, and an arrangement of the PM elements for providing an arrangement of the flux paths from the auxiliary field coil assemblies are also disclosed. |
| FILED | Tuesday, May 18, 2004 |
| APPL NO | 10/848450 |
| ART UNIT | 2834 — Electrical Circuits and Systems |
| CURRENT CPC | Electrical generator or motor structure 310/156.560 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989629 | Klebanoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | EUV LLC (Santa Clara, California) |
| INVENTOR(S) | Leonard E. Klebanoff (San Clemente, California); Daniel J. Rader (Albuquerque, New Mexico); William T. Silfvast (Helena, California) |
| ABSTRACT | Method and apparatus for mitigating the transport of debris generated and dispersed from electric discharge sources by thermophoretic and electrostatic deposition. A member is positioned adjacent the front electrode of an electric discharge source and used to establish a temperature difference between it and the front electrode. By flowing a gas between the member and the front electrode a temperature gradient is established that can be used for thermophoretic deposition of particulate debris on either the member or front electrode depending upon the direction of the thermal gradient. Establishing an electric field between the member and front electrode can aid in particle deposition by electrostatic deposition. |
| FILED | Friday, January 21, 2005 |
| APPL NO | 11/040627 |
| ART UNIT | 2879 — Optics |
| CURRENT CPC | Electric lamp and discharge devices 313/356 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989674 | Wind et al. |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Robert A. Wind (West Richland, Washington); Jian Zhi Hu (Richland, Washington); Kevin R. Minard (Kennewick, Washington); Donald N. Rommereim (Pasco, Washington) |
| ABSTRACT | The present invention relates to a probe and processes useful for magnetic resonance imaging and spectroscopy instruments. More particularly, the invention relates to a MR probe and processes for obtaining resolution enhancements of fluid objects, including live specimens, using an ultra-slow (magic angle) spinning (MAS) of the specimen combined with a modified phase-corrected magic angle turning (PHORMAT) pulse sequence. Proton NMR spectra were measured of the torso and the top part of the belly of a female BALBc mouse in a 2T field, while spinning the animal at a speed of 1.5 Hz. Results show that even in this relatively low field with PHORMAT, an isotropic spectrum is obtained with line widths that are a factor 4.6 smaller than those obtained in a stationary mouse. Resolution of 1H NMR metabolite spectra are thus significantly enhanced. Results indicate that PHORMAT has the potential to significantly increase the utility of 1H NMR spectroscopy for in vivo biochemical, biomedical and/or medical applications involving large-sized biological objects such as mice, rats and even humans within a hospital setting. For small-sized objects, including biological objects, such as excised tissues, organs, live bacterial cells, and biofilms, use of PASS at a spinning rate of 30 Hz and above is preferred. |
| FILED | Tuesday, August 12, 2003 |
| APPL NO | 10/639828 |
| ART UNIT | 2859 — Printing/Measuring and Testing |
| CURRENT CPC | Electricity: Measuring and testing 324/321 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 06988305 | Wilson |
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| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Magna International of America, Inc. (Troy, Michigan) |
| INVENTOR(S) | Phillip S. Wilson (Commerce Township, Michigan) |
| ABSTRACT | A method for molding large parts, comprises the steps of providing a reinforced plastic melt comprising at least one thermoplastic material and reinforcement particles dispersed within the at least one thermoplastic material, the reinforcement particles comprising less than 15% of a total volume of the plastic melt, at least 50% of the reinforcement particles having a thickness of less than about 20 nanomenters, and at least 99% of the reinforcement particles having a thickness of less than about 30 nanometers; communicating a tubular formation of the plastic melt to a mold assembly having a mold cavity defined by mold surfaces, the mold surfaces corresponding to a configuration of the part to be molded; applying pressurized gas to an interior of the tubular formation to expand the tubular formation into conformity with the mold surfaces; and solidifying the plastic melt to form the part; and removing the part from the mold assembly. |
| FILED | Friday, December 17, 1999 |
| APPL NO | 09/857767 |
| ART UNIT | 3726 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units |
| CURRENT CPC | Metal working 029/527.100 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06989086 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Nanogen, Inc. (San Diego, California) |
| INVENTOR(S) | Jing Cheng (San Diego, California); Edward L. Sheldon, III (San Diego, California); Lei Wu (San Diego, California); James P. O'Connell (San Diego, California) |
| ABSTRACT | The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cell lysates, and/or enzymatic reaction of such lysates, all of which can be conducted on a single bioelectronic chip. A preferred embodiment of the present invention comprises a cartridge (10) including a microfabricated silicon chip (12) on a printed circuit board (14) and a flow cell (16) mounted to the chip (12) to form a flow chamber. The cartridge (10) also includes output pins (22) for electronically connecting the cartridge (10) to an electronic controller. The chip (12) % includes a plurality of circular microelectrodes (24) which are preferably coated with a protective permeation layer. Specific cells from various cell mixtures were separated, lysed, and enzymatically digested on the chip. |
| FILED | Friday, July 13, 2001 |
| APPL NO | 09/905755 |
| ART UNIT | 1753 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Chemistry: Electrical and wave energy 24/547 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 06990135 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | Finisar Corporation (Sunnyvale, California) |
| INVENTOR(S) | Ralph H. Johnson (Murphy, Texas); Klein L. Johnson (Orono, Minnesota); Jimmy A. Tatum (Plano, Texas); James K. Guenter (Garland, Texas); James R. Biard (Richardson, Texas); Robert A. Hawthorne, III (Garland, Texas) |
| ABSTRACT | An oxide-confined VCSELs having a distributed Bragg reflector with a heavily doped high Al content oxide aperture forming layer disposed between a low Al content first layer and a medium Al content second layer. Between the first layer and the oxide aperture forming layer there may be a thin transition region wherein the Al content changes from a higher Al content to a lower Al content. In some embodiments, the Al concentration from the oxide aperture forming layer to the second layer may occur in a step. The oxide aperture forming layer may be disposed at or near a null or a node of the electric field produced by resonant laser light. During the oxidization of the oxide aperture forming layer, all or some of the other aluminum bearing DBR layers may also become oxidized, but to a substantially lesser degree. The junction between the oxidized portion and un-oxidized portion of these layers is believed to reduce the stability and/or reliability of the device. To alleviate this, the present invention contemplates providing an implant, etch or other suitable process to reduce or eliminate one or more electrical artifacts associated with the junction between the oxidized portion and un-oxidized portion of these layers as well as reducing the oxidation of other aluminum bearing layers of the DBR. |
| FILED | Monday, October 28, 2002 |
| APPL NO | 10/283381 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Coherent light generators 372/96 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 06989370 | Stern et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of Agriculture (Washington, District of Columbia); State Research Center for Applied Microbiology, Ministry of Health and Social Development, RF, as represented by the Director for the State Research Center for Applied Microbiology, Ministry of Health (, Russian Federation) |
| INVENTOR(S) | Norman J. Stern (Athens, Georgia); Edward A. Svetoch (Bolshevick, Russian Federation); Nikolay N. Urakov (Olympic Vill., Russian Federation); Boris V. Eruslanov (Obolensk, Russian Federation); Larisa I. Volodina (Obolensk, Russian Federation); Yuri N. Kovalev (Obolensk, Russian Federation); Tamara Y. Kudryavtseva (Obolensk, Russian Federation); Vladimir V. Perelygin (Lunacharskogo, Russian Federation); Victor D. Pokhilenko (Voroshilova, Russian Federation); Vladimir P. Levchuk (Dashkovka, Russian Federation); Valery N. Borzenkov (Obolensk, Russian Federation); Olga E. Svetoch (Bolshevick, Russian Federation); Eugeni V. Mitsevich (Obolensk, Russian Federation); Irina P. Mitsevich (Obolensk, Russian Federation) |
| ABSTRACT | Novel bacteriocins produced by novel bacterial strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry. |
| FILED | Thursday, May 01, 2003 |
| APPL NO | 10/426688 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Drug, bio-affecting and body treating compositions 514/12 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Federal Reserve Bank (FED)
| US 06990224 | Warren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Federal Reserve Bank of Atlanta (Atlanta, Georgia) |
| INVENTOR(S) | Joel Edward Warren (Brentwood, Tennessee); Reed Avon Beatse (Taylorsville, Utah); Jeremy Philip Becker (San Francisco, California); Thomas Vincent Costello (Southhampton, Pennsylvania); Hugh Francis Guilbeau, Jr. (San Francisco, California); Gopa Kumar (Castro Valley, California); Kevin Jude McCabe (Franklin, Massachusetts); Bruce Allen McPherson (Sausalito, California); David James Moore (Fairfax, California); Marilee Jean Niemi (Oakland, California); Danny Shawn Oursbourn (Rowlett, Texas); Cynthia Lynne Rasche (Arlington Heights, Illinois) |
| ABSTRACT | Communicating and matching electronic files for a check adjustment case comprises communicating an electronic check adjustment message comprising key data relating to the case, communicating an electronic image of a document to follow (“DTF”) related to the case, associating the key data with the electronic DTF image, determining whether the electronic message's key data matches the key data associated with the electronic DTF image, and linking the electronic message to the electronic DTF image in response to a determination that the electronic message's key data matches the key data associated with the electronic DTF image. If the DTF image's key data does not match the message's key data, matching electronic files can comprise correcting errors in the key data associated with the electronic DTF image and performing a secondary match routine. An operator accesses the electronic message and the linked DTF image to resolve the check adjustment case. |
| FILED | Thursday, May 15, 2003 |
| APPL NO | 10/439118 |
| ART UNIT | 2623 — Selective Visual Display Systems |
| CURRENT CPC | Image analysis 382/137 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 06990436 | Huang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| INVENTOR(S) | Norden E. Huang (Bethesda, Maryland) |
| ABSTRACT | This invention presents a method for computing Instantaneous Frequency by applying Empirical Mode Decomposition to a signal and using Generalized Zero-Crossing (GZC) and Extrema Sifting. The GZC approach is the most direct, local, and also the most accurate in the mean. Furthermore, this approach will also give a statistical measure of the scattering of the frequency value. For most practical applications, this mean frequency localized down to quarter of a wave period is already a well-accepted result. As this method physically measures the period, or part of it, the values obtained can serve as the best local mean over the period to which it applies. Through Extrema Sifting, instead of the cubic spline fitting, this invention constructs the upper envelope and the lower envelope by connecting local maxima points and local minima points of the signal with straight lines, respectively, when extracting a collection of Intrinsic Mode Functions (IMFs) from a signal under consideration. |
| FILED | Friday, November 28, 2003 |
| APPL NO | 10/729579 |
| ART UNIT | 2857 — Printing/Measuring and Testing |
| CURRENT CPC | Data processing: Measuring, calibrating, or testing 72/199 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 06990634 | Conroy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The United States of America as represented by the National Security Agency (Washington, District of Columbia) |
| INVENTOR(S) | John M. Conroy (Laurel, Maryland); Dianne P. O'Leary (Wheaton, Maryland) |
| ABSTRACT | A method of summarizing text. The sentences in the text are identified first. Then, the terms in each sentence are identified. A matrix is then generated, where the columns represent the sentences and the rows represent the terms. The entries in the matrix are weighted with an exponentially decaying function or a Hidden Markov Model. The Euclidean length of each column is determined. The sentence corresponding to the column having the maximum Euclidean length is selected as a summary sentence. The columns corresponding to the remaining sentences have their matrix entries reduced. If additional summary sentences are desired then return to the step of determining Euclidean length of the columns. |
| FILED | Friday, April 26, 2002 |
| APPL NO | 10/135100 |
| ART UNIT | 2178 — Graphical User Interface and Document Processing |
| CURRENT CPC | Data processing: Presentation processing of document, operator interface processing, and screen saver display processing 715/531 |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 06989842 | Cropper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Kevin M. Cropper (Columbia, Maryland); Jarrett F. Reid (Ellicott City, Maryland); David W. Nesbitt (Adamstown, Maryland) |
| ABSTRACT | A live video feed is seamlessly inserted into a static background image while maintaining the proper positioning and scaling of the combined image. The current frame of the live video feed is first texturized onto a surface. The surface is a set of points that are translated to the location, e.g., latitude/longitude coordinates, of the live video source. A series of matrix transformations of the texturized surface coordinates is performed. First, the texturized surface is rotated to be tangential to the earth at the location of the live video source. Next, the texturized surface is rotated again to reflect the heading of the live video source. Lastly, the texturized surface is scaled to conform to the background image. The transformed live image is then inserted into the larger background image in its proper position and displayed. |
| FILED | Thursday, October 25, 2001 |
| APPL NO | 10/363089 |
| ART UNIT | 2672 — Facsimile; Printer; Color; halftone; Scanner; Computer Graphic Processing; 3-D Animation; Display Color; Attributes; Object Processing; Hardware and Memory |
| CURRENT CPC | Computer graphics processing and selective visual display systems 345/629 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE38947 | Doyle |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | |
| ASSIGNEE(S) | Research Corporation Technologies, Inc. (Tucson, Arizona) |
| INVENTOR(S) | Michael P. Doyle (Glenn Dale, Maryland) |
| ABSTRACT | A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes a two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation. |
| FILED | Wednesday, February 14, 1996 |
| APPL NO | 08/601101 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Organic compounds 540/200 |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, January 24, 2006.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2006/fedinvent-patents-20060124.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page