FedInvent™ Patent Applications
Patent Application Details for Thursday, August 05, 2021
This page was updated on Thursday, August 05, 2021 at 08:54 PM GMT
Department of Health and Human Services (HHS)
| US 20210235686 | Hoehn et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard S. Hoehn (Cincinnati, Ohio); Peter L. Jernigan (Cincinnati, Ohio); Alex L. Chang (Cincinnati, Ohio); Charles C. Caldwell (Cincinnati, Ohio); Alex Lentsch (Cincinnati, Ohio); Michael J. Edwards (Cincinnati, Ohio); Erich Gulbins (Cincinnati, Ohio); Timothy A. Pritts (Cincinnati, Ohio) |
| ABSTRACT | Methods, additive kits and storage compositions for decreasing the deleterious effects of storage on pRBCs, for improving the aging process of stored pRBCs, and for preventing or ameliorating patient comorbidities following the transfusion or infusion of stored blood based on inhibiting acid sphingomyelinase during storage are provided. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212296 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) Original (OR) Class A01N 1/021 (20130101) A01N 1/0226 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236020 | MATIJEVICH et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily MATIJEVICH (Nashville, Tennessee); Leon SCOTT (Nashville, Tennessee); Karl ZELIK (Nashville, Tennessee) |
| ABSTRACT | A wearable device operably worn by a user for monitoring musculoskeletal loading on structure inside the body of the user includes a plurality of sensors, each sensor operably worn by the user at a predetermined location and configured to detect information about a biomechanical activity of musculoskeletal tissues, a limb segment orientation, and/or a loading magnitude or location thereon; and a processing unit in communication with the plurality of sensors and configured to process the detected information by the plurality of sensors to estimate the musculoskeletal loading, and communicate the estimated musculoskeletal loading to the user and/or a party of interest. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/051218 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/11 (20130101) Original (OR) Class A61B 5/296 (20210101) A61B 5/746 (20130101) A61B 5/4509 (20130101) A61B 5/4538 (20130101) A61B 5/4806 (20130101) A61B 5/6801 (20130101) A61B 5/6898 (20130101) A61B 5/7405 (20130101) A61B 5/7435 (20130101) A61B 5/7455 (20130101) A61B 2562/0219 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236021 | Najafi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bijan Najafi (Houston, Texas); Hadi Rahemi (Houston, Texas); Hyoki Lee (Houston, Texas); Hung Nguyen (Houston, Texas) |
| ABSTRACT | Lower extremity motion data may be received from one or more sensors. The lower extremity motion data may be used to quantify propulsion performance, which is used to calculate one or more gait characteristics of the lower extremity. A risk level of the lower extremity may be determined based, at least in part, on the calculated gait characteristics. |
| FILED | Thursday, May 02, 2019 |
| APPL NO | 17/052611 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/112 (20130101) Original (OR) Class A61B 5/6807 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/008 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236032 | PARK et al. |
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| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chung Hyuk PARK (Falls Church, Virginia); Hifza Javed (McLean, Virginia) |
| ABSTRACT | The disclosed system uses facial expressions and upper body movement patterns to detect autism spectrum disorder. Emotionally expressive robots participate in sensory experiences by reacting to stimuli designed to resemble typical everyday experiences, such as uncontrolled sounds and light or tactile contact with different textures. The robot-child interactions elicit social engagement from the children, which is captured by a camera. A convolutional neural network, which has been trained to evaluate multimodal behavioral data collected during those robot-child interactions, identifies children that are at risk for autism spectrum disorder. Because the robot-assisted framework effectively engages the participants and models behaviors in ways that are easily interpreted by the participants, the disclosed system may also be used to teach children with autism spectrum disorder to communicate their feelings about discomforting sensory stimulation (as modeled by the robots) instead of allowing uncomfortable experiences to escalate into extreme negative reactions (e.g., tantrums or meltdowns). |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159691 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 5/1128 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2021/0016 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236053 | Narayan et al. |
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| FUNDED BY |
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| APPLICANT(S) | (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjiv M. Narayan (Palo Alto, California); Mahmood Alhusseini (Palo Alto, California) |
| ABSTRACT | A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient. |
| FILED | Wednesday, April 24, 2019 |
| APPL NO | 17/051749 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/024 (20130101) A61B 5/361 (20210101) A61B 5/363 (20210101) A61B 5/0816 (20130101) A61B 5/4836 (20130101) Original (OR) Class A61B 5/7246 (20130101) A61B 5/7264 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) A61B 2562/0238 (20130101) A61B 2562/0271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210236067 — SYSTEMS AND RELATED METHODS FOR STATIONARY DIGITAL CHEST TOMOSYNTHESIS (S-DCT) IMAGING
| US 20210236067 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianping Lu (Chapel Hill, North Carolina); Jing Shan (Chapel Hill, North Carolina); Yueh Lee (Chapel Hill, North Carolina); Otto Z. Zhou (Chapel Hill, North Carolina); Jabari Calliste (Chapel Hill, North Carolina); Christina Inscoe (Holly Springs, North Carolina); Pavel Chtcheprov (Chapel Hill, North Carolina); Andrew Tucker (Cary, North Carolina) |
| ABSTRACT | Systems and related methods for stationary digital chest tomosynthesis (s-DCT) imaging are disclosed. In some aspects, systems include a stationary x-ray source array with an array of x-ray pixels configured to generate x-ray beams at different viewing angles relative to a subject to be imaged that is stationary, a stationary area x-ray detector configured to record x-ray projection images of the subject, a physiological gating apparatus for monitoring at least one physiological signal of the subject and defining a physiological phase and a time window based on the at least one physiological signal, and a computing platform configured to activate the x-ray pixels based on the physiological phase and the time window and upon receipt of the at least one physiological signal from the physiological gating apparatus in order to synchronize x-ray exposure with the at least one physiological signal of the subject. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234679 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/025 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/488 (20130101) A61B 6/502 (20130101) A61B 6/541 (20130101) A61B 6/4007 (20130101) A61B 6/4085 (20130101) A61B 6/5205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236072 | DEJONGH et al. |
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| FUNDED BY |
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| APPLICANT(S) | ProtonVDA LLC (Naperville, Illinois) |
| ASSIGNEE(S) | ProtonVDA LLC (Naperville, Illinois) |
| INVENTOR(S) | Don F. DEJONGH (Naperville, Illinois); Victor RYKALIN (Batavia, Illinois) |
| ABSTRACT | A medical imaging system includes a first tracking detector and a second tracking detector. The tracking detectors are spaced to allow for an object to be present between the first tracking detector and the second tracking detector. The system also includes a residual range detector adjacent the first tracking detector. The residual range detector includes: (1) a scintillator material having a first surface at least partially covered with an anti-reflection material and a second surface facing the first tracking detector and (2) at least one photon detector coupled to the scintillator material at a third surface of the scintillator material different than the first surface and opposite the second surface. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234540 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/582 (20130101) A61B 6/4216 (20130101) A61B 6/4258 (20130101) Original (OR) Class A61B 6/5205 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2005/1054 (20130101) Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/1603 (20130101) G01T 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236093 | Belohlavek |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marek Belohlavek (Scottsdale, Arizona) |
| ABSTRACT | In some embodiments of the disclosed subject matter, a system for tracking a medical device using color Doppler markers is provided, the medical device can comprise an ultrasound transmitter, and a lead configured to receive a square wave signal from a waveform generator and provide the square wave signal to the ultrasound transmitter causing the ultrasound transmitter to produce acoustic signals. The system can include an ultrasound machine having a display, a transducer that emits color Doppler signals, and a processor, which can be programmed to cause the transducer to emit the color Doppler signals, cause the transducer to detect color Doppler signals generated by an interaction between the emitted color Doppler signals and the acoustic signals, and generate an ultrasound image that includes a color Doppler marker indicative of the presence of the ultrasound transmitter. |
| FILED | Friday, June 07, 2019 |
| APPL NO | 16/973233 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/488 (20130101) Original (OR) Class A61B 8/0841 (20130101) A61B 8/5246 (20130101) A61B 34/20 (20160201) A61B 2034/2063 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236216 | Farritor et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shane Farritor (Lincoln, Nebraska); Amy Lehman (York, Nebraska); Mark Rentschler (Boulder, Colorado); Nathan Wood (Lincoln, Nebraska); Jason Dumpert (Omaha, Nebraska); Dmitry Oleynikov (Omaha, Nebraska) |
| ABSTRACT | The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217057 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 90/30 (20160201) A61B 90/37 (20160201) A61B 2017/00283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236328 | POPIELARSKI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Thermaquil, Inc. (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Thermaquil, Inc. (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stephen R. POPIELARSKI (Devon, Pennsylvania); Changfeng TAI (Wexford, Pennsylvania); Grant M. CHAPMAN (Indianapolis, Indiana) |
| ABSTRACT | Embodiments disclosed include systems, methods, and apparatuses, directed to administering thermal neural modulation to mammalian tissue to control nerve conduction. Embodiments disclosed include an apparatus comprising a thermal energy source, a first heat exchanger coupled to the thermal energy source and configured to receive thermal energy therefrom, a thermal applicator configured to be disposed and secured to the anatomy of a subject having a nerve therein, in contact with the skin on the anatomy and overlying a treatment portion of the nerve, the thermal applicator configured to transfer thermal energy to the skin to raise the temperature of the treatment portion of the nerve above a physiologic temperature, a second heat exchanger is coupled to the thermal applicator and configured to transfer thermal energy thereto, and a fluid conduit having a first portion coupled to the first heat exchanger and a second portion coupled to the second heat exchanger. The fluid conduit is configured to have fluid circulated therethrough to convey thermal energy from the thermal energy source via the first heat exchanger and to the thermal applicator via the second energy at a temperature. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127431 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) Original (OR) Class A61F 7/0085 (20130101) A61F 2007/0007 (20130101) A61F 2007/0054 (20130101) A61F 2007/0056 (20130101) A61F 2007/0071 (20130101) A61F 2007/0075 (20130101) A61F 2007/0086 (20130101) A61F 2007/0096 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/403 (20130101) A61N 5/025 (20130101) A61N 5/0622 (20130101) A61N 5/0625 (20130101) A61N 2005/0659 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236424 | Puri et al. |
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| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anu Puri (Frederick, Maryland); Mathias Viard (Frederick, Maryland) |
| ABSTRACT | Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259499 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 41/0071 (20130101) A61K 47/60 (20170801) A61K 47/543 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236465 | Yang |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingzi Yang (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides compositions and methods for inhibiting heterotopic ossification (HO) of a cell. Other embodiments of the invention include methods of treating a subject having heterotopic ossification or a subject at risk of developing HO, as well as methods for identifying a compound that inhibits heterotopic ossification (HO) of a cell. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/124640 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/409 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236469 | Freeman et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Bruce A. Freeman (Pittsburgh, Pennsylvania); Francisco J. Schopfer (Pittsburgh, Pennsylvania) |
| ABSTRACT | Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/070769 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/231 (20130101) A61K 31/232 (20130101) A61K 31/421 (20130101) A61K 31/426 (20130101) Original (OR) Class A61K 31/4166 (20130101) A61K 31/4192 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236470 | Wrobel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Edward Wrobel (Lawrenceville, New Jersey); Allen B. Reitz (Lansdale, Pennsylvania); Jeffrey Claude Pelletier (Lafayette Hill, Pennsylvania); Garry Robert Smith (Royersford, Pennsylvania); Haiyan Bian (Princeton, New Jersey) |
| ABSTRACT | Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151582 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/1617 (20130101) A61K 9/2004 (20130101) A61K 31/428 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/5377 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 277/82 (20130101) C07D 417/12 (20130101) Peptides C07K 5/0806 (20130101) C07K 5/0808 (20130101) C07K 5/0812 (20130101) C07K 5/06026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236471 | Wrobel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Edward Wrobel (Lawrenceville, New Jersey); Allen B. Reitz (Lansdale, Pennsylvania); Jeffrey Claude Pelletier (Lafayette Hill, Pennsylvania); Garry Robert Smith (Royersford, Pennsylvania); Haiyan Bian (Princeton, New Jersey) |
| ABSTRACT | Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/164654 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/1617 (20130101) A61K 9/2004 (20130101) A61K 31/428 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/5377 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/28 (20180101) Heterocyclic Compounds C07D 277/82 (20130101) C07D 417/12 (20130101) Peptides C07K 5/0806 (20130101) C07K 5/0808 (20130101) C07K 5/0812 (20130101) C07K 5/06026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236498 | Alam |
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| FUNDED BY |
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| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafeul Alam (Aurora, Colorado) |
| ABSTRACT | Disclosed herein are methods treating and identifying a subject having a steroid resistant disease or condition. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/0073 (20130101) A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 29/00 (20180101) A61P 37/08 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236500 | Thomas et al. |
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| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (PORTLAND, Oregon) |
| INVENTOR(S) | George Thomas (Portland, Oregon); Jennifer Podolak (Portland, Oregon); Hui-wen Lue (Portland, Oregon); Kevin Kolahi (Portland, Oregon) |
| ABSTRACT | Provided are methods and pharmaceutical combinations utilizing a phospholipase A2 inhibitor for the inhibition of treatment-induced autophagy. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236504 | LEWIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAYER PHARMA AKTIENGESELLSCHAFT (Berlin, Germany); THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | BAYER PHARMA AKTIENGESELLSCHAFT (BERLIN, Germany); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts) |
| INVENTOR(S) | TIMOTHY A. LEWIS (MARLBOROUGH, None); ALEX BURGIN (BOSTON, None); MONICA SCHENONE (CHESTNUT HILL, None); XIAOYUN WU (WINCHESTER, None); HEIDI GREULICH (ARLINGTON, Massachusetts); MATTHEW MEYERSON (CONCORD, Massachusetts); LUC DE WAAL (MEDFORD, Massachusetts); ANTJE MARGRET WENGNER (BERLIN, Germany); KNUT EIS (BERLIN, Germany); PHILIP LIENAU (BERLIN, Germany); ULRIKE SACK (BERLIN, Germany); MARTIN LANGE (BERLIN, Germany) |
| ABSTRACT | The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein). |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/50 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 413/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236516 | Lu |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurt Q. Lu (Cleveland, Ohio) |
| ABSTRACT | A method of treating or preventing skin damage in a subject in need thereof is described that includes administering to the subject a therapeutically effective amount of an autophagy activator, such as vitamin D. The method can include administering doses of the autophagy activator that are substantially higher than those typically used. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 16/811123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/00 (20130101) A61K 31/592 (20130101) A61K 31/593 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236533 | Rice et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin G. Rice (Iowa City, Iowa); Samuel T. Crowley (Iowa City, Iowa) |
| ABSTRACT | Double stranded mRNA, e.g., produced in vitro, as well as method of making and using the ds mRNA, are provided. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/001191 (20180801) A61K 2039/53 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236534 | Richter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel D. Richter (Boston, Massachusetts); Fen-Biao Gao (Boston, Massachusetts) |
| ABSTRACT | Translation modulating agents that modulate expression of one or more translation start sites for expanded repeat (e.g., DPR) protein synthesis are provided. Compositions and methods for treating translation start sites for expanded repeat (e.g., DPR) protein synthesis-associated disorders are also provided. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130908 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) A61K 31/712 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 31/7115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) C12N 2310/314 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2310/3233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236535 | Ranum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Laura Ranum (Gainesville, Florida); Fatma Ayhan (Lewisville, Texas); Tao Zu (Gainesville, Florida) |
| ABSTRACT | Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159288 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/14 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4705 (20130101) C07K 16/18 (20130101) C07K 2317/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236553 | ALBELDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven M. ALBELDA (Philadelphia, Pennsylvania); Liang-Chuan WANG (Philadelphia, Pennsylvania); Gary KORETZKY (Thorton, Pennsylvania); Matthew RIESE (Mequon, Wisconsin) |
| ABSTRACT | The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230791 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/45 (20130101) Peptides C07K 2/00 (20130101) C07K 16/30 (20130101) C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 9/16 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 207/01107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236558 | Shi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Yufang Shi (Belle Mead, New Jersey); Guangwen Ren (Piscataway, New Jersey); Liying Zhang (Belle Mead, New Jersey) |
| ABSTRACT | The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs). |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 38/191 (20130101) A61K 38/217 (20130101) A61K 38/2006 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) Peptides C07K 14/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0607 (20130101) C12N 5/0662 (20130101) C12N 5/0663 (20130101) C12N 5/0665 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236598 | RAFII et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Shahin RAFII (New York, New York); Bi-Sen DING (Bloomfield, New Jersey); Sina Y. RABBANY (Great Neck, New York) |
| ABSTRACT | A method of enhancing or initiating regeneration of an organ in a subject in need thereof comprising the administration of endothelial cells specific to said organ, or inductive endothelial cells specific to said organ, into the area of the body in which organ regeneration is desired in said subject. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165286 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/44 (20130101) A61K 38/1825 (20130101) A61K 38/1866 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) C12N 2502/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236608 | Remaley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (BETHESDA, Maryland); UNM RAINFOREST INNOVATIONS (ALBUQUERQUE, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Remaley (Bethesda, Maryland); John T. Schiller (Kensington, Maryland); Marcelo Amar (Gaithersburg, Maryland); Bryce Chackerian (Albuquerque, New Mexico) |
| ABSTRACT | A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 39/0005 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/6901 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6454 (20130101) Enzymes C12Y 304/21061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236612 | Zhang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Huang-Ge Zhang (Louisville, Kentucky) |
| ABSTRACT | Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD1 lc dendritic cells, and preventing or reducing metastasis. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/050200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 9/1277 (20130101) A61K 31/05 (20130101) A61K 31/12 (20130101) A61K 31/203 (20130101) A61K 31/337 (20130101) A61K 31/353 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 33/243 (20190101) A61K 38/12 (20130101) A61K 39/0012 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/001102 (20180801) A61K 2039/55 (20130101) A61K 2039/812 (20180801) A61K 2039/6018 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236615 | MURPHY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean C. MURPHY (Seattle, Washington); Bradley C. STONE (Seattle, Washington) |
| ABSTRACT | In one aspect, the present disclosure provides a trapping vaccine composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, wherein the trapping antigenic component comprises a nucleic acid molecule or a protein, the protective component comprises a synthetic or non-natural molecule or formation of synthetic or non-natural molecules, and wherein the liver cell-targeting component is capable of delivering the vaccine composition to a liver cell or liver tissue. The present disclosure additional provides vaccination methods comprising (i) administering a priming composition comprising a priming antigenic component or a first dose comprising the priming composition to the mammal; and (ii) administering a trapping composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, or a second dose comprising the second composition to the mammal, wherein the priming and trapping compositions or doses are not administered concurrently and wherein the number of resident memory T cells in the liver are increased following administration of the trapping composition. In certain embodiments, vaccine compositions and regimes are provided that protect against liver-tropic pathogens, e.g., a malarial infection. In an embodiment, a vaccine composition and regimen are provided that protect against an infection caused by P. falciparum or P. yoelli sporozoites. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/147438 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0053 (20130101) A61K 39/015 (20130101) Original (OR) Class A61K 47/6929 (20170801) A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236621 | Goodrum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of The University of Arizona (Tucson, Arizona); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Felicia Goodrum (Tucson, Arizona); Nathaniel Moorman (Chapel Hill, North Carolina); Jeremy Kamil (Shreveport, Louisiana) |
| ABSTRACT | Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259352 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/16121 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236622 | Zeng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mingtao Zeng (El Paso, Texas); Ke Wen (Harrison, New York) |
| ABSTRACT | The present invention includes a live, self-attenuated therapeutic vaccine, virus and methods of making and using the same, comprising: an isolated virus comprising a viral genome that expresses one or more viral antigens; and an artificial microRNA 30 (amiR-30) expression cassette inserted into a viral neuraminidase (NA) or a viral non-structural (NS) gene segment that expresses an amiR-30 that specifically inhibits the expression of a host gene essential for influenza virus replication in host cells. |
| FILED | Thursday, April 18, 2019 |
| APPL NO | 17/048714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/1131 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236625 | Jacobs, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Jacobs, Jr. (Pelham, New York); Betsy Herold (Rowayton, Connecticut); Joseph Dardick (Bronx, New York); Kayla A. Weiss (Bronx, New York) |
| ABSTRACT | Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, compositions and vaccines comprising such, and methods of use thereof are each provided. |
| FILED | Wednesday, May 01, 2019 |
| APPL NO | 17/051992 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class Peptides C07K 1/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/102 (20130101) C12N 2710/16034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236632 | Dowling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David J. Dowling (Brighton, Massachusetts); Ofer Levy (Cambridge, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Spencer E. Brightman (San Diego, California) |
| ABSTRACT | Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and/or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263515 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/438 (20130101) A61K 31/496 (20130101) A61K 31/739 (20130101) A61K 31/4025 (20130101) A61K 31/4535 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236645 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Song Li (Wexford, Pennsylvania); Jingjing Sun (Pittsburgh, Pennsylvania); Yichao Chen (Pittsburgh, Pennsylvania); Yixian Huang (Pittsburgh, Pennsylvania); Yanhua Liu (Pittsburgh, Pennsylvania); Binfeng Lu (Pittsburgh, Pennsylvania) |
| ABSTRACT | A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid. |
| FILED | Saturday, April 20, 2019 |
| APPL NO | 17/049152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/65 (20130101) A61K 47/58 (20170801) Original (OR) Class A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236650 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Liu (San Francisco, California); Scott Bidlingmaier (San Francisco, California); Yang Su (South San Francisco, California) |
| ABSTRACT | This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165833 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/17 (20130101) A61K 47/6803 (20170801) A61K 47/6811 (20170801) A61K 47/6871 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2809 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Enzymes C12Y 301/03001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236651 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Shunzhi Wang (Evanston, Illinois) |
| ABSTRACT | The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same. |
| FILED | Friday, July 13, 2018 |
| APPL NO | 16/629686 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) A61K 47/549 (20170801) A61K 47/6929 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236652 | Kohane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Daniel S. Kohane (Newton, Massachusetts); Yanfei Wang (Boston, Massachusetts) |
| ABSTRACT | The present invention generally relates to particles such as nanoparticles and, in particular, to targeted nanoparticles. In some cases, the particles may have a targeting moiety that is inhibited from recognizing a target, for example, by being positioned within the particle at an internal location. The application of a stimulus, such as light, may allow the targeting moiety to interact externally of the particle. Accordingly, the particles may be targeted to specific locations using the application of a suitable stimulus. For instance, in one embodiment, particles containing cell-penetrating peptides attached via a first attachment and a second attachment containing a photocleavable entity may be administered to a subject, and light may be applied, e.g., to the eye, to cleave the photocleavable entity. However, despite the cleavage, the peptides remain associated with the particle via the first attachment, and thus, the particles may be able to penetrate cells within the eye due to peptides. Other aspects are generally directed to methods of making or using such particles, kits involving such particles, or the like. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 17/057630 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 41/0042 (20130101) A61K 47/62 (20170801) A61K 47/68 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236656 | Braithwaite et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standord, California); U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia); ALKAHEST, INC. (San Carlos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Braithwaite (San Francisco, California); Saul A. Villeda (Lancaster, California); Anton Wyss-Coray (Palo Alto, California) |
| ABSTRACT | Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/16 (20130101) A61K 49/0008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236657 | Gibbs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon); OREGON STATE UNIVERSITY (Corvallis, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon); OREGON STATE UNIVERSITY (Corvallis, Oregon) |
| INVENTOR(S) | Summer L. Gibbs (West Linn, Oregon); Connor W. Barth (Portland, Oregon); Wathah G. Alani (Beaverton, Oregon); Vidhiben Shah (Hillsboro, Oregon); Lei Wang (Portland, Oregon) |
| ABSTRACT | Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/266549 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/1075 (20130101) A61K 47/10 (20130101) A61K 47/36 (20130101) A61K 47/40 (20130101) A61K 49/0028 (20130101) Original (OR) Class A61K 49/0054 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236659 | Zhou |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dong Zhou (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Dong Zhou (St. Louis, Missouri) |
| ABSTRACT | Described herein are methods and devices that allow the generation of [F-18]triflyl fluoride and other [F-18] sulfonyl fluorides (such as [F-18]tosyl fluoride) in a manner that is suitable for radiosynthesis of F-18 labeled radiopharmaceuticals using currently available synthesis modules. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150186 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0433 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/92 (20130101) B01J 27/232 (20130101) B01J 31/0237 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 39/00 (20130101) C07B 59/001 (20130101) C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 67/307 (20130101) C07C 67/317 (20130101) C07C 311/48 (20130101) C07C 315/04 (20130101) C07C 315/06 (20130101) C07C 2602/10 (20170501) Heterocyclic Compounds C07D 401/12 (20130101) C07D 487/06 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236662 | Tanifum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Children's Hospital (Houston, Texas) |
| ASSIGNEE(S) | Texas Children's Hospital (Houston, Texas) |
| INVENTOR(S) | Eric A. Tanifum (Richmond, Texas); Ketankumar B. Ghaghada (Sugar Land, Texas); Ananth V. Annapragada (Manvel, Texas) |
| ABSTRACT | A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162126 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/24 (20130101) A61K 49/108 (20130101) A61K 49/1812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236665 | PEREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesus Manuel PEREZ (Orlando, Florida); Santimukul SANTRA (Orlando, Florida) |
| ABSTRACT | Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 49/0423 (20130101) A61K 51/065 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/6882 (20130101) C08G 83/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236686 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woojin HAN (Atlanta, Georgia); Andres J. GARCIA (Atlanta, Georgia); Young C. JANG (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are hydrogels that can be loaded with myogenic agents, for instance muscle stem cells (MuSCs)/satellite cells, pro-myogenic factors, and combinations thereof. The hydrogels can be contacted with damaged muscle tissue, thereby facilitating muscle growth and repair. Further provided are methods of repairing muscle tissue in a patient in need thereof, said methods comprising contacting the muscle tissue with a composition comprising the hydrogel. Also provided herein are kits comprising the hydrogel composition and a substrate comprising at least one microneedle. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/263021 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/2096 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/008 (20130101) Original (OR) Class A61L 26/0047 (20130101) A61L 2300/412 (20130101) A61L 2430/30 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) A61M 2037/0023 (20130101) A61M 2037/0061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236773 | Dupont et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Pierre E. Dupont (Boston, Massachusetts); Georgios Fagogenis (Athens, Greece); Rosa Benoit (Sarrebourg, France); Margherita Mencattelli (Brooklyn, New York); Zurab Machaidze (Lexington, Massachusetts) |
| ABSTRACT | A robotic system comprising a robotic catheter steerable by a motorized drive system, an imaging device positioned on a distal end of the robotic catheter, and a controller configured to: process one or more images captured by the imaging device to identify an anatomical feature, implanted device, or medical instrument; estimate a location of the imaging device in the body based on the identified anatomical feature, implanted device, or medical instrument; determine, based on the estimated location of the imaging device, a direction in which to steer the robotic catheter for advancement towards an interventional site; and monitor at least one of (i) a stream of images captured by the imaging device and (ii) a force or distance measurement captured by the imaging device or a sensor proximate the imaging device, to adjust the direction in which to steer the robotic catheter during advancement towards the interventional site. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154486 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0116 (20130101) Original (OR) Class A61M 2205/332 (20130101) A61M 2205/583 (20130101) A61M 2205/3327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236824 | Grill |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Warren Grill (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for eliminating the onset response when blocking nerve conduction. The various embodiments disclosed herein include methods for designing waveforms that block nerve conduction without inducing an onset response, and systems for delivering treatment based on these waveforms to subjects with pathological neural activity. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167579 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36153 (20130101) A61N 1/36192 (20130101) Original (OR) Class A61N 1/37252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236845 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi-Ren Ng (Berkeley, California); Austin Roorda (Berkeley, California); Brian Schmidt (Berkeley, California); Utkarsh Singhal (Berkeley, California) |
| ABSTRACT | According to various embodiments of the invention, systems and methods for stimulating the retina are presented, by a combination of some or all of the following: imaging and mapping the retina; determining or assigning parameters on the retinal map, including real and virtual cell types and properties; tracking the head and/or eye; receiving or creating, transforming and/or projecting desired image signal onto the retinal map; combining the desired image with retinal parameter map data in order to determine per-cell or per-retinal-location stimulus values; and delivering the desired stimulus values to the retina. According to various embodiments of the invention, improved or novel color display, vision and perception are achieved: color gamut that encompasses the full human gamut; gamut that goes beyond the full human gamut; providing trichromatic vision functionality and/or color perception to dichromats, monochromats and/or individuals with anomalous color vision; providing perception of N-dimensional color, where N is higher than 3. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235627 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/067 (20130101) A61N 2005/0661 (20130101) A61N 2005/0663 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236992 | FAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhonghui Hugh FAN (Gainesville, Florida); Kangfu CHEN (Gainesville, Florida) |
| ABSTRACT | A lateral filter array microfluidic (LFAM) device for highly efficient immunoaffinity isolation of target cells from a population of cells. The LFAM device may include of one or more serpentine main channels incorporated with lateral filter arrays. Antibodies are immobilized on the channel surface including the lateral filters and are capable of specific binding to one or more biomolecules on the surface of the target cell. The device may include one or more arrays of lateral filters with different sizes. The overall filters sizes are close to the diameter of the target cell, therefore the interaction between biomarkers on the target cells and corresponding antibodies immobilized on the filter surface is largely strengthened due to the direct contact between target cells and lateral filters. Methods include flowing a population of cells through an antibody-coated LFAM device for target cells capture, followed by washing the device to remove non-specific captured cells. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/270167 |
| CURRENT CPC | Separation B01D 61/18 (20130101) B01D 61/147 (20130101) B01D 63/005 (20130101) Original (OR) Class B01D 2313/08 (20130101) B01D 2313/40 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/14 (20130101) C12M 23/16 (20130101) C12M 47/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238069 | Ball |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OXYTEC LLC (Newton, Massachusetts) |
| ASSIGNEE(S) | OXYTEC LLC (Newton, Massachusetts) |
| INVENTOR(S) | Raymond G. Ball (Newton, Massachusetts) |
| ABSTRACT | Disclosed are methods, apparatuses and systems for the remediation of contaminated soils, groundwater, water, and/or waste using a combination of reagents. The disclosed methods may be used to treat various recalcitrant halogenated substances, such as perfluoroalkyls and polyfluoroalkyls. Particular combinations of reagents that may be used in the disclosed methods include but are not limited to: (1) persulfate, oxygen and ozone; (2) persulfate, salt, oxygen and ozone; (3) persulfate, phosphate, and/or oxygen; (4) persulfate, phosphate, oxygen and ozone; (5) persulfate, phosphate, salt and oxygen (6) persulfate, phosphate, salt, oxygen and ozone; (7) oxygen and salt; and (8) air and salt. The disclosed methods may enhance destruction of organic contaminants in the liquid phase and may also control the rate of aerosol or foam formation relative to the rate of chemical oxidation and/or reduction/transfer. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/216089 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/002 (20130101) B09C 1/06 (20130101) B09C 1/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/32 (20130101) C02F 1/70 (20130101) C02F 1/78 (20130101) C02F 1/722 (20130101) Original (OR) Class C02F 1/725 (20130101) C02F 1/727 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238120 | Silverman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. Silverman (Winnetka, Illinois); Sida Shen (Chicago, Illinois) |
| ABSTRACT | Disclosed are cyclopentene compounds for use as inhibitors of aminotransferases such as gamma-aminobutyric acid (GABA) aminotransferase (AT) and/or ornithine aminotransferase (OAT). The disclosed cyclopentene compounds include 3-amino-4-halocyclopente carboxylic acid compounds which may be formulated in pharmaceutical composition for treating diseases and disorders associated with GABA-AT and/or OAT activity, including epilepsy, addiction, hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC). |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155706 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 61/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238125 | Imig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Johann Wolfgang Goethe-Universität Frankfurt (Frankfurt am Main, Germany) |
| ASSIGNEE(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin); Johann Wolfgang Goethe-Universität Frankfurt (Frankfurt am Main, Germany) |
| INVENTOR(S) | John David Imig (Pewaukee, Wisconsin); Md. Abdul Hye Khan (Milwaukee, Wisconsin); Eugen Proschak (Frankfurt am Main, Germany); Rene Blocher (Frankfurt am Main, Germany) |
| ABSTRACT | N-benzylbenzamides that act as dual soluble epoxide hydrolase (sEH)/peroxisome proliferator-activated receptor γ (PPARγ) modulators and are useful as medications in the treatment of Metabolic Syndrome (MetS) cluster diseases, including diabetes. Methods of making and using the same are further provided. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/132310 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/062 (20130101) A61B 18/1492 (20130101) A61B 2034/2051 (20160201) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0012 (20130101) A61M 25/0127 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Acyclic or Carbocyclic Compounds C07C 233/65 (20130101) C07C 233/66 (20130101) Original (OR) Class C07C 233/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238140 | Garkavtsev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Garkavtsev (Cambridge, Massachusetts); Rakesh K. Jain (Wellesley, Massachusetts) |
| ABSTRACT | This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided. |
| FILED | Tuesday, July 18, 2017 |
| APPL NO | 16/318846 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 251/80 (20130101) Heterocyclic Compounds C07D 213/53 (20130101) C07D 213/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238145 | SAWYERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles L. SAWYERS (New York, New York); Michael JUNG (Los Angeles, California); Charlie D. CHEN (Shanghai, China PRC); Samedy OUK (San Diego, California); Derek WELSBIE (Lutherville-Timonium, Maryland); Chris TRAN (New York, New York); John WONGVIPAT (New York, New York); Dongwon YOO (Los Angeles, California) |
| ABSTRACT | The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/088148 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/70 (20130101) C07D 233/74 (20130101) C07D 233/86 (20130101) C07D 235/02 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238147 | LINDSEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina); The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher C. LINDSEY (Wadmalaw Island, South Carolina); Craig C. BEESON (Charleston, South Carolina); Yuri Karl PETERSON (Charleston, South Carolina); Rick G. SCHNELLMANN (Tucson, Arizona) |
| ABSTRACT | Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Heterocyclic Compounds C07D 239/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238164 | HAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Crinetics Pharmaceuticals, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangdon HAN (San Diego, California); Yunfei ZHU (San Diego, California); Sun Hee KIM (San Diego, California); Jian ZHAO (San Diego, California); Shimiao WANG (San Diego, California) |
| ABSTRACT | Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170396 |
| CURRENT CPC | Heterocyclic Compounds C07D 295/04 (20130101) C07D 401/10 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 407/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238187 | NICOLAOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Kyriacos C NICOLAOU (Houston, Texas); Derek RHOADES (Bellwefontaine, Ohio); Yangping WANG (Shandong Province, China PRC) |
| ABSTRACT | In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided. |
| FILED | Wednesday, April 11, 2018 |
| APPL NO | 16/604837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) Heterocyclic Compounds C07D 491/044 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238189 | Canney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania); Praeventix, LLC (Exton, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Kevin M. Blattner (Folsom, Pennsylvania); Douglas A. Pippin (Chester Springs, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. |
| FILED | Wednesday, September 09, 2020 |
| APPL NO | 17/015696 |
| CURRENT CPC | Heterocyclic Compounds C07D 221/00 (20130101) C07D 295/073 (20130101) C07D 309/08 (20130101) C07D 413/10 (20130101) C07D 491/107 (20130101) Original (OR) Class C07D 493/10 (20130101) C07D 513/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238213 | Greenberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc M. Greenberg (Baltimore, Maryland); Haozhe Yang (Baltimore, Maryland) |
| ABSTRACT | A strategy using reverse phosphoramidites for synthesizing oligonucleotides containing Fapy.dG is disclosed. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161272 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) Original (OR) Class C07H 19/06 (20130101) C07H 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238220 | REDDY |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (COLLEGE STATION, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOODIPALA SAMBA REDDY (BRYAN, Texas) |
| ABSTRACT | Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids. |
| FILED | Tuesday, April 23, 2019 |
| APPL NO | 17/049976 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) Steroids C07J 5/0015 (20130101) C07J 41/0088 (20130101) C07J 43/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238225 | GRAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael GRAY (Boston, Massachusetts); Benika PINCH (Brookline, Massachusetts); Sirano DHE-PAGANON (Holliston, Massachusetts); Hyuk-Soo SEO (Cambridge, Massachusetts); Chris BROWNE (Brookline, Massachusetts); Jarrod MARTO (Boston, Massachusetts); Zainab DOCTOR (Boston, Massachusetts); Kun Ping LU (Newton, Massachusetts); Xiao ZHOU (Newton, Massachusetts); Shingo KOZONO (Brookline, Massachusetts); Xiaolan LIAN (Fuzhou, China PRC) |
| ABSTRACT | Disclosed are compounds which inhibit Pin1 activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysregulated Pin1 activity. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251084 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 5/1016 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238250 | VEATCH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua VEATCH (Seattle, Washington); Stanley R. RIDDELL (Sammamish, Washington); Sylvia LEE (Seattle, Washington) |
| ABSTRACT | The present disclosure provides binding proteins, such as TCRs, that specifically bind various tumor associated antigens (including human BRAFV600E epitope), cells expressing such antigen specific binding proteins, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells express BRAFV600E, such as in cancer. |
| FILED | Friday, August 10, 2018 |
| APPL NO | 16/638339 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 7/00 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238254 | Seidel, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald D. Seidel, III (Larchmont, New York); Rodolfo J. Chaparro (Bronx, New York); Brandan S. Hillerich (Ithaca, New York); Scott J. Garforth (Bronx, New York); Steven C. Almo (Pelham, New York) |
| ABSTRACT | Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided. |
| FILED | Tuesday, August 25, 2020 |
| APPL NO | 17/001847 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/70539 (20130101) Original (OR) Class C07K 2319/00 (20130101) C07K 2319/30 (20130101) C07K 2319/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238262 | Krebs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Government of the United States as Represented by the Secretary of the Army (Silver Spring, Maryland) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Government of the United States as Represented by the Secretary of the Army (Silver Spring, Maryland) |
| INVENTOR(S) | Shelly Krebs (Bethesda, Maryland); Gina Donofrio (Rockville, Maryland); Vincent Dussupt (Silver Spring, Maryland); Kayvon Modjarrad (Bethesda, Maryland); Dan Barouch (Boston, Massachusetts); Richard G. Jarman, III (Silver Spring, Maryland); Nelson L. Michael (Silver Spring, Maryland); Gordon Joyce (Silver Spring, Maryland) |
| ABSTRACT | The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus. |
| FILED | Wednesday, April 24, 2019 |
| APPL NO | 17/049800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238266 | Breuer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Breuer (Columbus, Ohio); Narutoshi Hibino (Columbus, Ohio); Vidu Garg (Columbus, Ohio); Cameron Best (Columbus, Ohio) |
| ABSTRACT | Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/098076 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/713 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/54 (20130101) A61L 27/507 (20130101) A61L 29/16 (20130101) A61L 31/16 (20130101) A61L 2300/42 (20130101) A61L 2300/256 (20130101) A61L 2300/258 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238274 | McNally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IKAIKA THERAPEUTICS, LLC (Oak Park, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois); Ahlke Heydemann (Oak Park, Illinois); Ermelinda Ceco (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta binding protein (LTBP4)-induced proteolysis of a TGFβ superfamily protein. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 16/18 (20130101) C07K 16/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238276 | TUCKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTEGRAL MOLECULAR, INC. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David F. TUCKER (Philadelphia, Pennsylvania); Kimberly-Anne MATTIA (Philadelphia, Pennsylvania); Christine R. FISHER (Philadelphia, Pennsylvania); Benjamin J. DORANZ (Philadelphia, Pennsylvania); Joseph B. RUCKER (Philadelphia, Pennsylvania) |
| ABSTRACT | Antibodies and compositions against GLUT4 and uses thereof are provided herein. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/051241 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/705 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238279 | FU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dax FU (Short Hills, New Jersey); Chengfeng Merriman (Essex, Maryland) |
| ABSTRACT | The present invention relates to the fields of immunology and autoimmunity. More specifically, the present invention provides methods and compositions directed to the generation and use of antibodies to the pancreatic zinc transporter, ZnT8. The present invention also provides an isolated antibody or antigen-binding fragment thereof that specifically binds ZnT8 comprising a VH comprising one of the amino acid sequences set forth in SEQ ID NOS:2, 12, 22, 32, 42 and 52. In alternative embodiments an isolated antibody or antigen-binding fragment thereof that specifically binds ZnT8 comprises a VL comprising one of the amino acid sequences as set forth in SEQ ID NOS:7, 17, 27, 37, 47 and 57. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268925 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/33 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238284 | Jaiswal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddhartha Jaiswal (San Francisco, California); Irving L. Weissman (Stanford, California); Ravindra Majeti (Palo Alto, California); Mark P. Chao (Mountain View, California) |
| ABSTRACT | Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, acute leukemia cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 47/6851 (20170801) A61K 47/6861 (20170801) A61K 47/6863 (20170801) A61K 47/6865 (20170801) A61K 47/6867 (20170801) A61K 47/6869 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 16/3038 (20130101) C07K 16/3046 (20130101) C07K 16/3053 (20130101) C07K 16/3061 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238312 | ALT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Frederick W. ALT (Cambridge, Massachusetts); Suvi JAIN (Boston, Massachusetts); Zhaoqing BA (Boston, Massachusetts); Ming TIAN (Boston, Massachusetts) |
| ABSTRACT | Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization. |
| FILED | Monday, June 10, 2019 |
| APPL NO | 16/973125 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2207/15 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) Peptides C07K 16/461 (20130101) Original (OR) Class C07K 2317/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238523 | Thon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan N. Thon (Watertown, Massachusetts); Jorge Valdez (Watertown, Massachusetts); Marcus Lehmann (Watertown, Massachusetts); Douglas G. Sabin (Woburn, Massachusetts); Shawn Murphy (Woburn, Massachusetts); Shweta V. Krishnan (Woburn, Massachusetts) |
| ABSTRACT | The instant disclosure provides a system comprising a plurality of stacked bioreactors, wherein the system is configured to provide a substantially equal flow rate of fluid and pressure drop through each of the plurality of bioreactors. In some embodiments, the flow of the fluid through each of the plurality of bioreactors is configured to generate physiological shear rates to induce a biological source material in the bioreactors to produce target biological products. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/259829 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/10 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238534 | McCully et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. McCully (Marblehead, Massachusetts); Douglas B. Cowan (Brighton, Massachusetts); Pedro J. Del Nido (Lexington, Massachusetts); Thomas Duignan (Jamica Plain, Massachusetts) |
| ABSTRACT | An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/052709 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 33/14 (20130101) C12M 41/14 (20130101) C12M 41/48 (20130101) Original (OR) Class C12M 47/20 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/042 (20130101) G01N 33/5079 (20130101) G01N 2035/00356 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210238556 — Synergistic Genome-Nonintegrating Reprogramming by Micrornas and Transcription Factors
| US 20210238556 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The McLean Hospital Corporation (Belmont, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kwang-Soo Kim (Lexington, Massachusetts); Young Cha (Lexington, Massachusetts) |
| ABSTRACT | Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells, contacting the contacting the somatic or non-embryonic cells with a quantity of one or more programming factors and one or more RNA molecules, and culturing the somatic or non-embryonic cells for a period of time sufficient to generate at least one induced pluripotent stem cell. Various reprogramming factors and RNA molecules for use in the methods are disclosed herein. Also disclosed are cell lines and pharmaceutical compositions generated by use of the methods. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2501/65 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2506/1307 (20130101) C12N 2510/00 (20130101) C12N 2799/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238569 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Bryan Dickinson (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/123632 |
| CURRENT CPC | Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/50 (20130101) Original (OR) Class C12N 9/1247 (20130101) C12N 15/52 (20130101) C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/1037 (20130101) C12N 15/1058 (20130101) C12N 2795/00022 (20130101) Enzymes C12Y 207/07006 (20130101) C12Y 304/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238592 | Yen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laising Yen (Houston, Texas); Sachin Kumar Gupta (Houston, Texas); Jocelyn Duen-Ya Jea (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions in which two inter-chromosomal or intra-chromosomal genomic DNA regions are rearranged upon exposure of the genomic DNA to a chimeric RNA that produces fusion of the two regions. The chimeric RNA hybridizes to the two different parts of the genomic DNA and forms a DNA/RNA hybrid in a sequence-specific manner, thereby facilitating genomic rearrangement. In particular embodiments this mechanism is utilized to produce directed gene fusion in targeted genomic DNA regions. |
| FILED | Tuesday, April 16, 2019 |
| APPL NO | 17/047924 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238593 | REDDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TEXAS TECH UNIVERSITY SYSTEM (Lubbock, Texas) |
| ASSIGNEE(S) | Texas Tech University System (Lubbock, Texas) |
| INVENTOR(S) | P. Hemachandra REDDY (Lubbock, Texas); Murali VIJAYAN (Lubbock, Texas) |
| ABSTRACT | The present invention includes methods for detecting and reducing or inhibiting ischemic stroke in a mammal, the method comprising: (a) selecting microRNAs to downregulate selected from the group consisting of hsa-miR-96-5p, hsa-miR-99a-5p, hsa-miR-122-5p, hsa-miR-186-5p, hsa-miR-211-5p, hsa-mir-760, PC-3p-57664, orPC-5p-12969, (b) selecting microR-NAs to upregulate selected from the group consisting of ggo-miR-139, hsa-miR-30d-5p, hsa-miR-22-3p, hsa-miR-23a-3p, mmu-miR-5124a, mmu-mir-6240-5p, PC-3p-32463, or PC-5p-211, and combinations thereof, and (c) administering an agent that: downregulates that targets in (a), upregulates the targets in (b), or both, to the subject in an amount sufficient to reduce or inhibit ischemic stroke in the mammal. The present invention also includes the detection of the markers for use with stroke patients. |
| FILED | Thursday, April 18, 2019 |
| APPL NO | 17/049041 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238621 | Daniell |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henry Daniell (Media, Pennsylvania) |
| ABSTRACT | Enzyme containing compositions and methods are disclosed which are useful for treating cellulosic materials, such as textiles. Also provided are transgenic plants expressing one or more enzymes and compositions comprising crude extracts obtained therefrom useful for the treatment of foodstuffs which are suitable for human consumption after treatment. |
| FILED | Thursday, August 22, 2019 |
| APPL NO | 17/270382 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/88 (20130101) C12N 9/2437 (20130101) C12N 9/2494 (20130101) C12N 15/8214 (20130101) C12N 15/8246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238643 | Leal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nicole A Leal (Gainesville, Florida); Steven A Benner (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole A Leal (Gainesville, Florida); Steven A Benner (Gainesville, Florida) |
| ABSTRACT | This invention relates to nucleotide analogs and their derivatives (termed non-standard nucleotides) that, when incorporated into DNA and RNA, expand the number of nucleotides beyond the four found in standard DNA and RNA. The invention further relates to enzymatic processes that incorporate those non-standard nucleotide analogs into oligonucleotide products using the corresponding triphosphate derivatives. The RNA polymerases of the instant invention transcribe DNA containing nonstandard nucleotides to give RNA containing nonstandard nucleotides, where certain of those nucleotides have nucleobases that do not present electron density to the minor groove. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188248 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238658 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Hawaii (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lena Diaz (Morrison, Colorado); Daniel McKewn Jenkins (Honolulu, Hawaii) |
| ABSTRACT | The present invention relates to delivering sample preparation technologies to enhance the performance of point-of-care agricultural diagnostics by improving the capacity to detect trace contaminations of pathogenic organisms along the entire food supply chain including pre- and post-harvest processing and distribution. Sample preparation is crucial for adequate test performance of downstream diagnostics like LAMP and supports sensitive detection of bacterial contaminates. This invention increases the speed and scale of routine pathogen surveillance and the efficacy of management response and mitigation of foodborne disease outbreaks. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/259647 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/465 (20130101) C02F 1/5263 (20130101) C02F 1/46109 (20130101) C02F 2001/46133 (20130101) C02F 2001/46171 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238665 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Felice Alessio Bava (Menlo Park, California); Yury Goltsev (Stanford, California); Garry P. Nolan (Redwood City, California) |
| ABSTRACT | SNAIL provides cost-efficient detection of specific nucleic acids in single cells, and may be combined with flow cytometry to simultaneously analyze large numbers of cells for a plurality of nucleic acids, e.g. at least one, to up to 5, up to 10, up to 15, up to 20 or more transcripts can be simultaneously analyzed, at a rate of up to about 50, 100, 250, 500 or more cells/second. The methods require only two primers for amplification, and may further include a detection primer. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230706 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6841 (20130101) Original (OR) Class C12Q 2525/307 (20130101) C12Q 2531/125 (20130101) C12Q 2533/107 (20130101) C12Q 2543/10 (20130101) C12Q 2600/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238670 | CHEE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (Encinitas, California) |
| ABSTRACT | The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237948 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238671 | CHEE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (Encinitas, California) |
| ABSTRACT | The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237962 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238681 | Sarwal et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Minnie Sarwal (Portola Valley, California); Marina Sirota (Belmont, California); Silvia Pineda San Juan (San Francisco, California) |
| ABSTRACT | Disclosed are novel methods of assessing transplant rejection status in a transplant recipient, such as a kidney transplant recipient. The diagnostic method identifies stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes using measurement of TCR subunit repertoire diversity. The proportion of unique TCR alpha and beta subunit sequences to total unique TCR subunit sequences (total sequences for alpha, beta, delta, and gamma subunits) provides a diagnostic measure that can identify stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes. Methods of treatment include administration of a suitable treatment if antibody mediated rejection or cell mediated rejection is detected. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/980369 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238682 | HE et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (DURHAM, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (DURHAM, North Carolina) |
| INVENTOR(S) | YOU-WEN HE (DURHAM, North Carolina); YU WANG (JINZHOU, LIAONING, China PRC); NELSON CHAO (DURHAM, North Carolina) |
| ABSTRACT | Provided are compositions and methods for donor selection and prognosis of acute graft-versus-host disease. Provided is a method, which comprises obtaining a first biological sample from a first subject at risk of GVHD; detecting a level of miR-142-3p in the sample; and determining a risk of, prognosis of, or diagnosis of GVHD in the first subject. Provided also is a method for selecting a stem cell transplant donor, which comprises obtaining a first biological sample from a first subject and a second biological sample from a second subject, detecting a level of miR-142-3p in the first biological sample and the second biological sample; determining a ratio of the level of miR-142-3p in the second biological sample to the level of miR-142-3p in the first biological sample; determining the likelihood of the first subject will develop GVHD based on the ratio; and selecting a transplant donor based on the ratio. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238697 | KASSIS |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an infectious agent-specific signature in an infected individual are provided. Methods and compositions for diagnosing the presence of a disease in an individual are also provided. Methods and compositions for identifying a disease-specific signature in an individual having the disease are also provided. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/233625 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/569 (20130101) G01N 33/5023 (20130101) G01N 33/5047 (20130101) G01N 33/5052 (20130101) G01N 33/5055 (20130101) G01N 33/5091 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) G01N 33/57449 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239109 | Wikswo et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky) |
| ABSTRACT | A peristaltic micropump include a plurality of channels, each channel being flexible, having a middle channel portion, and being operably in fluidic communications with a first port and a second port, and the middle channel portions of the plurality of channels being arranged in one or more concentric circles; and an actuator comprising a bearing assembly driven by a motor, the bearing assembly comprising a plurality of rolling members and a bearing accommodating member for accommodating the plurality of rolling members, the actuator being positioned in relation to the plurality of channels such that when the bearing accommodating member rotates, the plurality of rolling members rolls along the one or more concentric circles of the middle channel portions of the plurality of channels to cause individually fluids to transfer between the first port and the second port of each of the plurality of channels simultaneously at different flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269329 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/12 (20130101) F04B 43/0054 (20130101) F04B 43/0072 (20130101) F04B 43/1253 (20130101) F04B 43/1269 (20130101) Original (OR) Class F04B 43/1292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239450 | HENDON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTINE HENDON (Bronx, New York); RICHARD HA (White Plains, New York); DIANA MOJAHED (New York, New York); HANINA HIBSHOOSH (New York, New York); JAMES MCLEAN (New York, New York) |
| ABSTRACT | An exemplary system for generating an image(s) of a sample(s) can include, for example, an imaging arrangement that can include a superluminescent diode (SLD) configured to generate a radiation(s) to be provided to the sample(s), and a spectrometer configured to (i) sample an A-line sampling rate of at least about 200kHz, (ii) receive a resultant radiation from the sample(s) based on the sampling rate, and (iii) generate information based on the resultant radiation, and a computer hardware arrangement configured to generate the image(s) of the sample(s) based on the information received from the spectrometer. The imaging arrangement can be an interferometric imaging arrangement, which can be an optical coherence tomography imaging (OCT) arrangement. The computer hardware arrangement can be further configured to facilitate a plurality of b-scan acquisitions of the sample(s) and facilitate the b-scan acquisitions in order to generate the image(s). |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162720 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02091 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239591 | Berezin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mikhail Y. Berezin (St. Louis, Missouri); John Mark Meacham (St. Louis, Missouri); Michael Binkley (St. Louis, Missouri) |
| ASSIGNEE(S) | WASHINGTON UNIVERSITY (St. Louis, Missouri) |
| INVENTOR(S) | Mikhail Y. Berezin (St. Louis, Missouri); John Mark Meacham (St. Louis, Missouri); Michael Binkley (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein is are methods for isolating mammalian cells under continuous flow conditions, enriching mammalian cells under continuous flow conditions, and enriching microorganisms under continuous flow conditions. The methods include providing and loading a plurality of mammalian cells or microorganisms into an acoustic separation device. The acoustic separation device includes: an inlet; an outlet; a channel coupled to the inlet and the outlet, wherein the channel defines a flow path between the inlet and the outlet; a standing acoustic wave generating device; and at least one pillar array comprising a plurality of pillars, wherein the at least one pillar array is situated within the flow path defined by the channel, wherein the at least one pillar array includes a first pillar array and a second pillar array, wherein the first pillar array is substantially parallel to the second pillar array, wherein the first pillar array and the second pillar array form an enrichment structure. The methods further include generating an augmented pressure field comprising locally augmenting, by the enrichment structure, a pressure field generated by the standing acoustic wave generating device. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222358 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/0829 (20130101) B01L 2300/0864 (20130101) B01L 2400/086 (20130101) B01L 2400/0436 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) Original (OR) Class G01N 33/54373 (20130101) G01N 2015/142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239602 | Yang et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Darren Yang (Cambridge, Massachusetts); Andrew Ward (Boston, Massachusetts); Wesley Philip Wong (Cambridge, Massachusetts); Kenneth Anders Halvorsen (Glenmont, New York) |
| ABSTRACT | An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167847 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 21/07 (20130101) Original (OR) Class G01N 33/53 (20130101) G01N 33/543 (20130101) G01N 33/557 (20130101) G01N 2015/0038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239617 | Paulsen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); UNIVERSITY HEALTH NETWORK (Toronto, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith D. Paulsen (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire); Dennis Wirth (Hanover, New Hampshire); Brian C. Wilson (Toronto, Canada); Mira Sibai (Toronto, Canada) |
| ABSTRACT | A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/050745 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4795 (20130101) G01N 21/6456 (20130101) Original (OR) Class G01N 33/4833 (20130101) G01N 2201/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239618 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Ji-Xin CHENG (Newton, Massachusetts); Haonan LIN (Allston, Massachusetts) |
| ABSTRACT | Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162455 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 5/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239680 | Koo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sophia Koo (Brookline, Massachusetts); Horatio R. Thomas (Cambridge, Massachusetts); James Constantine Comolli (Boxborough, Massachusetts); Preshious Rearden (Melrose, Massachusetts); Lindsey R. Baden (Brookline, Massachusetts); Francisco M. Marty (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/069641 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) A61K 31/496 (20130101) A61K 31/513 (20130101) A61K 31/7048 (20130101) A61K 38/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) Original (OR) Class G01N 33/56961 (20130101) G01N 2033/4977 (20130101) G01N 2333/38 (20130101) G01N 2500/10 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239686 | Ghosh |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradipta Ghosh (San Diego, California) |
| ABSTRACT | The present invention provides a Fluorescence Resonance Energy Transfer (FRET) biosensor that measures the metastatic potential and/or chemoresistance of single living cancer cells, and/or cells associated with fibrogenesis, diabetes, aging, and/or infertility. |
| FILED | Monday, May 13, 2019 |
| APPL NO | 17/051293 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) Original (OR) Class G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239708 | COON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Joshua COON (Middleton, Wisconsin); Harald MARX (Madison, Wisconsin) |
| ABSTRACT | In shotgun proteomics, generally only a fraction of peptides from a parent protein are actually detected. Because a large portion of the protein sequence is not detected, it is often impossible to determine whether the expressed protein is present in a modified, spliced, or truncated form. Provided herein are methods and systems for analyzing polypeptides which allow for the increase of the mean sequence coverage of a protein concomitant with bioinformatics analysis in order to distinguish putative proteoforms with improved amino acid resolution. Aspects of the invention include (1) a deep sequencing strategy to provide more protein sequence coverage than is typically achieved, and (2) a computational approach to view protein expression across its full length and identify regions of the protein that are potentially subject to such regulation. This technology has global utility in proteomics and will be of particular use for the analysis of biosimilar protein drug therapeutics. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231977 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6824 (20130101) G01N 33/6842 (20130101) G01N 33/6848 (20130101) Original (OR) Class G01N 2570/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 40/00 (20190201) G16B 40/10 (20190201) G16B 40/30 (20190201) Electric Discharge Tubes or Discharge Lamps H01J 49/004 (20130101) H01J 49/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239775 | Gallippi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caterina M. Gallippi (Cary, None); Keita Andrew Yokoyama (Chapel Hill, North Carolina); Md Murad Hossain (Chapel Hill, None) |
| ABSTRACT | A method for quantitatively measuring a physical characteristic of a material includes performing one or more interrogations of a material sample, each interrogation using a push focal configuration. The method further includes taking measurements of displacement over time of a material sample caused by the one or more interrogations. Each measurement uses an interrogation focal configuration. The method further includes determining a physical characteristic of the material sample based on the measurements of displacement over time of the material sample. According to the method, at least one of the following is true: a tracking focal configuration used for one of the measurements is different from a tracking focal configuration used for another of the measurements; and a push focal configuration used for one of the interrogations is different from a push focal configuration used for another of the interrogations. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150612 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/24 (20130101) Original (OR) Class G01R 33/36 (20130101) G01R 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239780 | Fan et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiuyun Fan (Malden, Massachusetts); Susie Yi Huang (Boston, Massachusetts); Qiyuan Tian (Charlestown, Massachusetts); Chanon Ngamsombat (Boston, Massachusetts) |
| ABSTRACT | Diffusion metric maps are generated from a limited input of magnetic resonance data to a suitably trained machine learning algorithm, such as a suitably trained neural network. In general, a downsampling strategy is implemented in the joint k-q space to enable the simultaneous estimation of multiple different diffusion metrics from a more limited set of input diffusion-weighted images. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166734 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4818 (20130101) G01R 33/5608 (20130101) G01R 33/56341 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/008 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239911 | Song et al. |
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| FUNDED BY |
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| APPLICANT(S) | ChiSquare Bioimaging LLC (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loling Song (Chestnut Hill, Massachusetts); Hendrik van Gorsel (Chestnut Hill, Massachusetts) |
| ABSTRACT | An automated fiber optic rotary joint (FORJ) dynamically measures, using an angle encoder, twists in an optical fiber cable caused by movements of a mouse or other animal and automatically unwinds the optical fiber cable(s) by engaging a motor. To optimize its efficiency, the unwinding process is activated automatically only when the angle encoder reaches a predetermined threshold. In some embodiments, the optical fiber is unwound in increments of 360°. Various embodiments allow simultaneous transfer of optical signals through independent channels to and from multiple sites of a freely moving animal through a rotating interface and with minimal mechanical impact on the natural behavior of the animal. The design principle leads to a minimal variation of light transmission over rotation suitable for life science applications. A single channel FORJ device can be readily expanded to a two-, three- or more-channel device. |
| FILED | Sunday, January 24, 2021 |
| APPL NO | 17/156600 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) Diagnosis; Surgery; Identification A61B 5/6868 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0622 (20130101) Optical Elements, Systems, or Apparatus G02B 6/3604 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239955 | DAI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongjie DAI (Cupertino, California); Feifei WANG (Palo Alto, California) |
| ABSTRACT | Provided are methods of near-infrared II light sheet microscopy with excitation and emission up to between about 1320 nm and about 2400 nm, respectively, for optical sectioning through live tissues with improved penetration depth without any invasive surgery. The methods allow for normal and oblique configurations enabled in vivo imaging of live mice through intact tissue, revealing such as abnormal blood flow and T cell motion in tumor microcirculation and mapping out programmed-death ligand 1 and programmed cell death protein 1 (PD-1) in tumors with cellular resolution. 3D imaging through intact mouse heads resolved vascular channels between skull and brain cortex, and monitored recruitment of macrophages/microglia to traumatic brain injury site post injury. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 16/972151 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2333/70553 (20130101) G01N 2333/70596 (20130101) Optical Elements, Systems, or Apparatus G02B 5/208 (20130101) G02B 21/02 (20130101) G02B 21/0032 (20130101) Original (OR) Class G02B 21/0076 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239956 | Waller et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Laura Waller (Berkeley, California); Hillel Adesnik (Kensington, California); Nicolas C. Pégard (Berkeley, California) |
| ABSTRACT | Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153421 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240945 | STRACHAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| INVENTOR(S) | John Paul STRACHAN (Milpitas, California); Dejan S. MILOJICIC (Milpitas, California); Martin FOLTIN (Ft. Collins, Colorado); Sai Rahul CHALAMALASETTI (Milpitas, California); Amit S. SHARMA (Milpitas, California) |
| ABSTRACT | In some examples, a device includes a first processing core comprising a resistive memory array to perform an analog computation, and a digital processing core comprising a digital memory programmable with different values to perform different computations responsive to respective different conditions. The device further includes a controller to selectively apply input data to the first processing core and the digital processing core. |
| FILED | Monday, April 30, 2018 |
| APPL NO | 17/049031 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/4027 (20130101) G06F 15/80 (20130101) G06F 17/16 (20130101) Hybrid Computing Arrangements G06J 1/00 (20130101) Original (OR) Class Static Stores G11C 13/0069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241137 | Jain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vignet Incorporated (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Josh Schilling (Salem, Oregon) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for using machine learning to generate precision predictions of readiness. In some implementations, a database is accessed to obtain status data that indicates activities or attributes of a subject. A set of feature scores is derived from the status data for the subject, the set of feature scores including values indicative of attributes or activities of the subject. The set of feature scores to one or more models that have been configured to predict readiness of subjects to satisfy one or more readiness criteria. The one or models can be models configured using machine learning training. Based on processing performed using the one or more machine learning models and the set of feature scores, a prediction regarding the subject's ability to achieve readiness to satisfy the one or more readiness criteria is generated. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 16/781582 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241139 | Jain et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vignet Incorporated (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Josh Schilling (Salem, Oregon) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for using machine learning to improve processes for achieving readiness. In some implementations, a database is accessed to obtain status data that indicates activities or attributes of a subject. One or more readiness scores indicating a level of capability of the subject to satisfy one or more readiness criteria are generated. Data is accessed indicating multiple candidate actions for improving capability of the subject to satisfy one or more readiness criteria. A subset of the candidate actions for the subject are selected based on the one or more readiness scores generated using the one or more models. Output is provided to cause one or more of the actions in the selected subset to be performed or cause an indication one or more of the actions in the selected subset to be presented on a user interface. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 16/781793 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242415 | Scheuermann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | James Scheuermann (Katonah, New York); Wei Zhao (East Setauket, New York) |
| ABSTRACT | A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155446 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/241 (20130101) G01T 1/247 (20130101) G01T 1/2018 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/307 (20130101) H01L 27/308 (20130101) H01L 51/4213 (20130101) Original (OR) Class H01L 2031/0344 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210236218 | Palmowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Palmowski (Pasadena, California); Shane Farritor (Lincoln, Nebraska) |
| ABSTRACT | Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236489 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/30 (20160201) Original (OR) Class A61B 2034/305 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/102 (20130101) B25J 9/126 (20130101) B25J 17/0258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236306 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher O. Evans (Amherst, New Hampshire); N. Christopher Perry (Manchester, New Hampshire); Dirk A. van der Merwe (Canterbury, New Hampshire); Keith D. Violette (Sandown, New Hampshire); Stewart M. Coulter (Bedford, New Hampshire); Thomas A. Doyon (Manchester, New Hampshire); David Blumberg, JR. (Deerfield, New Hampshire) |
| ABSTRACT | A prosthetic arm apparatus including a plurality of segments that provide a user of the prosthetic arm apparatus with substantially the same movement capability and function as a human arm. The segments are connectable to one another and connectable to a prosthetic support apparatus that may be adorned by the user. Some segments may provide movement about more than one axis using a single actuator. The prosthetic arm apparatus may include a user interface incorporated therein and may include one or more communication systems for communicating with external devices. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155392 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) Original (OR) Class A61F 2/68 (20130101) A61F 2/70 (20130101) A61F 2/78 (20130101) A61F 2/581 (20130101) A61F 2/582 (20130101) A61F 2/585 (20130101) A61F 2/586 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 15/0009 (20130101) B25J 18/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236452 | Ari D'Agostino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Csilla Ari D'Agostino (Tampa, Florida); Dominic Paul D'Agostino (Tampa, Florida) |
| ABSTRACT | Methods of treating anxiety disorders or reducing anxiety-related behaviors. The methods include administering a therapeutically effective amount of ketone supplementation, such as butanediol, ketone esters (e.g., 1,3-butanediol-acetoacetate diester) and/or ketone salts (e.g., beta-hydroxybutyrate-mineral salt), chronically, sub-chronically, or acutely, with or without admixture with a medium chain triglyceride or in combination. It was determined herein that ketone supplementation reduced anxiety in rats on elevated plus maze as measured by less entries to closed arms, more time spent in open arms, more distance travelled in open arms, and delayed latency to entrance to closed arms, when compared to control. Along with reducing anxiety-related behavior, the chronic, sub-chronic, and acute ketone supplements also caused significant elevation of blood βHB levels and changed blood glucose levels. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234382 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/12 (20160801) A23L 33/16 (20160801) A23L 33/30 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/19 (20130101) A61K 31/22 (20130101) Original (OR) Class A61K 31/23 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236651 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Shunzhi Wang (Evanston, Illinois) |
| ABSTRACT | The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same. |
| FILED | Friday, July 13, 2018 |
| APPL NO | 16/629686 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) A61K 47/549 (20170801) A61K 47/6929 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236837 | Lu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/269970 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236982 | Alptekin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TDA Research, Inc. (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gökhan O. Alptekin (Boulder, Colorado); Douwe Bruinsma (Louisville, Colorado); Ambalavanan Jayaraman (Highlands Ranch, Colorado); Brandon Gushlaw (Boulder, Colorado) |
| ABSTRACT | A vacuum assisted pressure swing adsorption device for purifying oxygen from air, comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series. A method for producing medical oxygen using a vacuum assisted pressure swing adsorption device comprising: a first adsorption bed of LiLSX adsorbent and second adsorption bed of AgLiLSX adsorbent, wherein the first adsorption bed and the second adsorption bed are connected to each other in series. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/168147 |
| CURRENT CPC | Separation B01D 53/0407 (20130101) B01D 53/0476 (20130101) Original (OR) Class B01D 2253/304 (20130101) B01D 2256/12 (20130101) B01D 2257/104 (20130101) B01D 2259/402 (20130101) B01D 2259/4533 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237528 | FLORY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (NEW HUDSON, Michigan) |
| ASSIGNEE(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (NEW HUDSON, Michigan) |
| INVENTOR(S) | KENNETH J. FLORY (WEST BLOOMFIELD, Michigan); JESPER SLATTENGREN (ANN ARBOR, Michigan); GUIDO FRANCESCO RITELLI (FARMINTON HILLS, Michigan) |
| ABSTRACT | A hydraulic suspension system for a motor vehicle having at least a pair of road engaging wheels. The suspension system includes, a hydraulic cylinder coupled with the each of the pair of road engaging wheels, the hydraulic cylinder defining a cap end volume and a rod end volume separated by a piston. A hydraulic supply circuit for the hydraulic cylinder includes, a high pressure hydraulic source, a low pressure hydraulic drain, a pair of hydraulic sub circuits each coupled to one of the hydraulic cylinder cap and rod end volumes. Each hydraulic sub circuit includes, a proportional supply flow valve coupled with the high pressure hydraulic source and one of the cylinder volumes, a return flow control proportional valve coupled with the low pressure hydraulic drain and the one cylinder volume, and an accumulator coupled to the associated hydraulic cylinder volume through an accumulator fill control proportional valve. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048874 |
| CURRENT CPC | Vehicle Suspension Arrangements B60G 11/265 (20130101) Original (OR) Class B60G 17/056 (20130101) B60G 2202/154 (20130101) B60G 2202/413 (20130101) B60G 2202/414 (20130101) B60G 2202/416 (20130101) B60G 2300/07 (20130101) B60G 2500/114 (20130101) B60G 2600/182 (20130101) B60G 2800/912 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238129 | Wipf |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Peter Wipf (Pittsburgh, Pennsylvania) |
| ABSTRACT | Selective potassium channel agonists and methods of use thereof are disclosed. A compound, or a pharmaceutically acceptable salt thereof, having a formula I wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted C1-C6 alkyl or optionally-substituted cyclopropyl; R3 and R4 are each independently H or optionally-substituted alkyl; R5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R6 and R7 are each independently H, optionally-substituted alkyl, or R6 and R7 together form a carbocycle; R8 is substituted phenyl or optionally-substituted pyridinyl, provided that if R8 is substituted phenyl, then R2 is optionally-substituted cyclopropyl; and R9, R10 and R11 are each independently H, halo, or optionally-substituted alkyl. |
| FILED | Friday, March 08, 2019 |
| APPL NO | 17/048878 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) A61P 27/16 (20180101) Acyclic or Carbocyclic Compounds C07C 271/26 (20130101) Original (OR) Class C07C 271/38 (20130101) Heterocyclic Compounds C07D 213/38 (20130101) C07D 213/61 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238140 | Garkavtsev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Garkavtsev (Cambridge, Massachusetts); Rakesh K. Jain (Wellesley, Massachusetts) |
| ABSTRACT | This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided. |
| FILED | Tuesday, July 18, 2017 |
| APPL NO | 16/318846 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 251/80 (20130101) Heterocyclic Compounds C07D 213/53 (20130101) C07D 213/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238145 | SAWYERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Charles L. SAWYERS (New York, New York); Michael JUNG (Los Angeles, California); Charlie D. CHEN (Shanghai, China PRC); Samedy OUK (San Diego, California); Derek WELSBIE (Lutherville-Timonium, Maryland); Chris TRAN (New York, New York); John WONGVIPAT (New York, New York); Dongwon YOO (Los Angeles, California) |
| ABSTRACT | The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/088148 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/70 (20130101) C07D 233/74 (20130101) C07D 233/86 (20130101) C07D 235/02 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238262 | Krebs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Government of the United States as Represented by the Secretary of the Army (Silver Spring, Maryland) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Government of the United States as Represented by the Secretary of the Army (Silver Spring, Maryland) |
| INVENTOR(S) | Shelly Krebs (Bethesda, Maryland); Gina Donofrio (Rockville, Maryland); Vincent Dussupt (Silver Spring, Maryland); Kayvon Modjarrad (Bethesda, Maryland); Dan Barouch (Boston, Massachusetts); Richard G. Jarman, III (Silver Spring, Maryland); Nelson L. Michael (Silver Spring, Maryland); Gordon Joyce (Silver Spring, Maryland) |
| ABSTRACT | The invention described herein provides antibodies to Zika virus. The novel polypeptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Zika virus. |
| FILED | Wednesday, April 24, 2019 |
| APPL NO | 17/049800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238330 | MOORE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Jeffrey S. MOORE (Savoy, Illinois); Scott R. WHITE (Champaign, Illinois); Ian D. ROBERTSON (Philadelphia, Pennsylvania); Nancy R. SOTTOS (Champaign, Illinois); Jia E. AW (Champaign, Illinois) |
| ABSTRACT | The present disclosure provides a novel method of 3D printing using frontal polymerization chemistry. This method enables the printing of tough, high quality thermosets in a short time with the option of adding fiber reinforcement. As such, it facilitates fabrication of mechanically robust 3D-printed devices and structures. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149446 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/87 (20190201) B29C 48/911 (20190201) B29C 64/106 (20170801) B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 70/384 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 232/08 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238523 | Thon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Platelet Biogenesis, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan N. Thon (Watertown, Massachusetts); Jorge Valdez (Watertown, Massachusetts); Marcus Lehmann (Watertown, Massachusetts); Douglas G. Sabin (Woburn, Massachusetts); Shawn Murphy (Woburn, Massachusetts); Shweta V. Krishnan (Woburn, Massachusetts) |
| ABSTRACT | The instant disclosure provides a system comprising a plurality of stacked bioreactors, wherein the system is configured to provide a substantially equal flow rate of fluid and pressure drop through each of the plurality of bioreactors. In some embodiments, the flow of the fluid through each of the plurality of bioreactors is configured to generate physiological shear rates to induce a biological source material in the bioreactors to produce target biological products. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/259829 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/10 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238569 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Bryan Dickinson (Cambridge, Massachusetts); Michael S. Packer (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein. |
| FILED | Wednesday, December 16, 2020 |
| APPL NO | 17/123632 |
| CURRENT CPC | Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/50 (20130101) Original (OR) Class C12N 9/1247 (20130101) C12N 15/52 (20130101) C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/1037 (20130101) C12N 15/1058 (20130101) C12N 2795/00022 (20130101) Enzymes C12Y 207/07006 (20130101) C12Y 304/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238570 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaojing Gao (Pasadena, California); Lucy S. Chong (Pasadena, California); Michael Elowitz (Pasadena, California); Mark William Budde (Pasadena, California); Matthew Sun-min Kim (Pasadena, California) |
| ABSTRACT | Some embodiments of the systems, methods and compositions provided herein relate to a compound protease. In some embodiments, the compound protease includes a protease domain and a cut site for another enzyme. In some embodiments, the compound protease includes an association domain. In some embodiments, the compound protease is part of a protein circuit. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157880 |
| CURRENT CPC | Peptides C07K 2319/50 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) C12N 9/96 (20130101) C12N 9/506 (20130101) Original (OR) Class Enzymes C12Y 105/01003 (20130101) C12Y 304/21098 (20130101) C12Y 304/22044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238650 | Medintz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Medintz (Washington, District of Columbia); Joyce A. Breger (Washington, District of Columbia); Kimihiro Susumu (Washington, District of Columbia); Sebastian Diaz (Washington, District of Columbia); Jesper Brask (Lyngby, Denmark) |
| ABSTRACT | Lipase activity can be detected with a biosensor that includes a quantum dot adhered to a construct having a lipase-cleavable ester to attach a fluorophore acceptor configured as a Förster resonance energy transfer (FRET) acceptor to the QD when the construct is bound thereto. Cleavage of the ester by a lipase results in a measurable reduction in FRET. In further embodiments, the cleavable ester can be used to detect esterase activity, or the ester could be replaced with a glycosidic linkage to detect glycoside activity. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/161889 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/565 (20130101) C09K 11/883 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) C12Q 1/44 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238696 | Freedman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina); George Washington University (Washington, District of Columbia) |
| INVENTOR(S) | Jennifer Freedman (Durham, North Carolina); Yanru Wang (Durham, North Carolina); Hongliang Liu (Durham, North Carolina); Qingyi Wei (Durham, North Carolina); Daniel George (Durham, North Carolina); Steven Patierno (Durham, North Carolina); Bi-Dar Wang (Potomac, Maryland); Norman Lee (Dayton, Maryland) |
| ABSTRACT | The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238697 | KASSIS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an infectious agent-specific signature in an infected individual are provided. Methods and compositions for diagnosing the presence of a disease in an individual are also provided. Methods and compositions for identifying a disease-specific signature in an individual having the disease are also provided. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/233625 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/569 (20130101) G01N 33/5023 (20130101) G01N 33/5047 (20130101) G01N 33/5052 (20130101) G01N 33/5055 (20130101) G01N 33/5091 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) G01N 33/57449 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239070 | Perr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ACHATES POWER, INC. (San Diego, California) |
| ASSIGNEE(S) | ACHATES POWER, INC. (San Diego, California) |
| INVENTOR(S) | Andrew P. Perr (Columbus, Indiana); John J. Koszewnik (Colorado Springs, Colorado); Gary A. Vrsek (Howell, Michigan) |
| ABSTRACT | A parent bore cylinder block of an internal combustion, opposed-piston engine includes cooling passages that are formed using a 3-D printed casting core. The casting core can include portions that are ceramic. The parent bore cylinder block can include multiple cylinders, each cylinder with cooling passages and turbulence inducing features in those cooling passages, particularly surrounding the central portions of the cylinders. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/213008 |
| CURRENT CPC | Foundry Moulding B22C 9/10 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 29/002 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Cooling of Machines or Engines in General; Cooling of Internal-combustion Engines F01P 3/02 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 75/28 (20130101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/10 (20130101) Original (OR) Class F02F 1/14 (20130101) F02F 2200/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239071 | Perr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ACHATES POWER, INC. (San Diego, California) |
| ASSIGNEE(S) | ACHATES POWER, INC. (San Diego, California) |
| INVENTOR(S) | Andrew P. Perr (Columbus, Indiana); John J. Koszewnik (Colorado Springs, Colorado); Gary A. Vrsek (Howell, Michigan) |
| ABSTRACT | A parent bore cylinder block of an internal combustion, opposed-piston engine includes cooling passages that are formed using a 3-D printed casting core. The casting core can include portions that are ceramic. The parent bore cylinder block can include multiple cylinders, each cylinder with cooling passages and turbulence inducing features in those cooling passages, particularly surrounding the central portions of the cylinders. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/213039 |
| CURRENT CPC | Foundry Moulding B22C 9/10 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 29/002 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Cooling of Machines or Engines in General; Cooling of Internal-combustion Engines F01P 3/02 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 75/28 (20130101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/10 (20130101) Original (OR) Class F02F 1/14 (20130101) F02F 2200/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239109 | Wikswo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky) |
| ABSTRACT | A peristaltic micropump include a plurality of channels, each channel being flexible, having a middle channel portion, and being operably in fluidic communications with a first port and a second port, and the middle channel portions of the plurality of channels being arranged in one or more concentric circles; and an actuator comprising a bearing assembly driven by a motor, the bearing assembly comprising a plurality of rolling members and a bearing accommodating member for accommodating the plurality of rolling members, the actuator being positioned in relation to the plurality of channels such that when the bearing accommodating member rotates, the plurality of rolling members rolls along the one or more concentric circles of the middle channel portions of the plurality of channels to cause individually fluids to transfer between the first port and the second port of each of the plurality of channels simultaneously at different flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269329 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/12 (20130101) F04B 43/0054 (20130101) F04B 43/0072 (20130101) F04B 43/1253 (20130101) F04B 43/1269 (20130101) Original (OR) Class F04B 43/1292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239132 | DiPietro, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Louis DiPietro, JR. (Mainesville, Ohio); Andrew Breeze-Stringfellow (Montgomery, Ohio); Gregory John Kajfasz (Morrow, Ohio) |
| ABSTRACT | A variable-cycle compressor includes: an axial-flow compressor, a flowpath downstream of the compressor, and at least one variable-cycle device operable to vary a choked flow capacity of the downstream flowpath. The compressor includes: a rotor having at least one rotor stage including a rotatable disk defining a rotor flowpath surface and an array of axial-flow rotor airfoils extending outward from the flowpath surface; at least one stator stage including a wall defining a stator flowpath surface, and an array of axial-flow stator airfoils extending away from the stator flowpath surface. At least one stage includes splitter airfoils alternating with the rotor or stator airfoils of the corresponding stage. At least one of a chord dimension of the splitter airfoils and a span dimension of the splitter airfoils is less than the corresponding dimension of the airfoils of the at least one stage. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227529 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/34 (20130101) F01D 5/146 (20130101) F01D 9/041 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 25/045 (20130101) F04D 29/324 (20130101) F04D 29/544 (20130101) F04D 29/563 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2220/36 (20130101) F05D 2240/12 (20130101) F05D 2240/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239776 | WALTER, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NOKOMIS, INC. (Charleroi, Pennsylvania) |
| ASSIGNEE(S) | NOKOMIS, INC. (CHARLEROI, Pennsylvania) |
| INVENTOR(S) | WALTER, III (BRIGEVILLE, Pennsylvania); ADAM TAYLOR BRANT (EIGHTY FOUR, Pennsylvania); ANDREW RICHARD PORTUNE (OAKDALE, Pennsylvania); JAMES ROBERT UPLINGER, II (CRANBERRY TWP, Pennsylvania); TODD ERIC CHORNENKY (CARMICHAELS, Pennsylvania) |
| ABSTRACT | A device to extract digital and unintended analog signals from a data bus with a non-contact common mode probe and a differential mode probe, each with a low noise amplifier. The analog and digital signals can be monitored contemporaneously. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 16/797803 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/341 (20130101) G01R 33/34007 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 41/005 (20130101) H01F 41/079 (20160101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239880 | Zuraski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the secrectary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven M. Zuraski (Beavercreek, Ohio); Elizabeth A. Beecher (Beavercreek, Ohio); Steven T. Fiorino (Beavercreek, Ohio); Jason D. Schmidt (Waynesville, Ohio); Jack E. McCrae, JR. (Bellbrook, Ohio); Nathan Figlewski (Valrico, Florida) |
| ABSTRACT | Systems, methods and apparatus to profile atmospheric turbulence. The apparatus includes a telescope having a telescope optical axis and a laser to generate a plurality of pulses at a pulse repetition rate. A laser beam mechanism, coupled to the laser, has a laser optical axis substantially coincident with the telescope optical axis, such that the plurality of pulses forms a collimated laser beam propagating along the telescope optical axis. The apparatus also includes at least one shutter coupled to the telescope and one or more wavefront sensors, coupled to the shutter, which acts as a range gate for the wavefront sensor. A controller is coupled to the laser and the shutter to coordinate operation of the shutter with a pulse of the plurality of pulses. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 16/778424 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 9/00 (20130101) G01J 2009/002 (20130101) Meteorology G01W 1/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239942 | Hall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Fort Belvoir, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M. Hall (Stafford, Virginia); Andrew J. Dotson (Washington, District of Columbia); Brian D. Kellermeyer (Fort Belvoir, Virginia) |
| ABSTRACT | The current invention describes a compact objective lens with enhanced distortion for near-infrared imaging, comprising a positively powered, aspheric, and meniscus first lens element; a negatively powered, aspheric, and meniscus second lens element; a positively powered, aspheric, and biconvex third lens element; a negatively powered, aspheric, and meniscus fourth lens element; a negatively powered, aspheric, and meniscus field corrector element; and a detector assembly comprising a window and a detector plane where the light rays come to focus. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 16/781341 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 9/60 (20130101) G02B 13/008 (20130101) Original (OR) Class G02B 13/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240159 | Taber et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intact Solutions, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | Intact Solutions, Inc. (Madison, Wisconsin) |
| INVENTOR(S) | Andrew Taber (Madison, Wisconsin); Goldy Kumar (Madison, Wisconsin); Michael Freytag (Madison, Wisconsin); Vadim Shapiro (Madison, Wisconsin) |
| ABSTRACT | Methods and system for computing integrals over geometric domains using moment-base representations for interoperability are disclosed. A first computing device may receive data for geometric and field representations of an object, the geometric representation specifying a geometric domain of the object, and the field representation specifying a spatially varying physical quantity. The first computing device may integrate a predetermined set of basis functions over the geometric domain multiplied by a field to derive a moment-vector for the object, the moment-vector encapsulating an analytic formulation of the geometric domain that is independent of the geometric and field representations. The first computing device may computationally generate quadrature rules for integrating an arbitrary function by applying moment-fitting to the moment-vector. The quadrature rules may be provided to a second computing device, which may integrate the arbitrary function over the geometric domain by applying the quadrature rules, independently of the geometric and field representations. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204006 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) Original (OR) Class G05B 2219/35107 (20130101) G05B 2219/35134 (20130101) G05B 2219/35151 (20130101) Electric Digital Data Processing G06F 17/11 (20130101) G06F 17/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240891 | Karimoddini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina Agricultural and Technical State University (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Karimoddini (Greensboro, North Carolina); Solomon Grebreyohannes (Greensboro, North Carolina); Abdollah Homaifar (Greensboro, North Carolina) |
| ABSTRACT | Methods and systems for virtually testing an autonomous vehicle. In some examples, a method includes receiving status reports from a simulated system of the autonomous vehicle for each of a number of simulated scenes. The method uses a fuzzy approximate reasoning to take system and environmental conditions into consideration to evaluate if mismatches with truth data are reasonable or not. The method includes outputting test results for the system of the autonomous vehicle by, for each of the simulated scenes, performing operations comprising: fuzzifying status parameters from the status report for the simulated scene into fuzzy input parameters; mapping the fuzzy input parameters through a set of rules for the system of the autonomous vehicle into fuzzy output parameters; and mapping the fuzzy output parameters into one or more crisp test result outputs. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/148909 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 50/045 (20130101) Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) G06K 9/6262 (20130101) G06K 2209/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241059 | Church |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates to methods of storing data using one or more nucleic acids. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235196 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/00 (20130101) G06K 19/022 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241100 | Hopkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jonathan Hopkins (Los Angeles, California); Ali Hatamizadeh (Los Angeles, California); Yuanping Song (Los Angeles, California) |
| ABSTRACT | A boundary learning optimization tool for training neural networks with accurate models of parameterized flexure using a minimal number of numerically generated performance solutions generated from different design instantiations of those topologies. Performance boundaries are output by the neural network in optimization steps, with geometric parameters varied from smallest allowable feature sizes to largest geometrically compatible feature sizes for given constituent materials. The plotted performance boundaries define the design spaces of flexure systems toward allowing designers to visually identify which geometric versions of their synthesized topologies best achieve desired combinations of performance capabilities. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139800 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241401 | McCollum et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (, None) |
| INVENTOR(S) | Duane J. McCollum (Seattle, Washington); Michael A. Snow (Williamsburg, Virginia) |
| ABSTRACT | A method includes accessing, by a processor of a computing device, metadata of a data file associated with a mixed-IP rights project. The method also includes performing, by the processor, a comparison of values of metadata field(s) of the metadata to a rights criterion. The method further includes, based on whether the comparison indicates that values of the one or more metadata fields satisfy the rights criterion, storing data indicating assignment of an IP rights label of a set of candidate IP rights labels to the data file. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 16/778044 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/15 (20200101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) G06Q 10/0875 (20130101) G06Q 50/184 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241947 | Jonker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Berend T. Jonker (Waldorf, Maryland) |
| ABSTRACT | The invention relates to heterostructures including a layer of a two-dimensional material placed on a multiferroic layer. An ordered array of differing polarization domains in the multiferroic layer produces corresponding domains having differing properties in the two-dimensional material. When the multiferroic layer is ferroelectric, the ferroelectric polarization domains in the layer produce local electric fields that penetrate the two-dimensional material. The local electric fields can influence properties of the two-dimensional material, including carrier density, transport properties, optical properties, surface chemistry, piezoelectric-induced strain, magnetic properties, and interlayer spacing. Methods for producing the heterostructures are provided. Devices incorporating the heterostructures are also provided, including tunable sensors, optical emitters, and programmable logic gates. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208756 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/414 (20130101) G01N 27/4146 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/009 (20130101) Original (OR) Class H01F 10/1933 (20130101) H01F 10/3222 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/778 (20130101) H01L 29/1606 (20130101) H01L 29/66984 (20130101) H01L 29/78391 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242108 | Jensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Ralph W. Jensen (Tumwater, Washington); Michael Thomas Crocker (Portland, Oregon); Wesley B. Morgan (Lake Oswego, Oregon) |
| ABSTRACT | Techniques for liquid cooling systems are disclosed. In one embodiment, jet holes in a water block create jets of liquid coolant to be applied to a surface to be cooled, such as a surface of an integrated circuit component. The jets of liquid coolant may disrupt surface boundary layers through turbulence and/or microcavitation, increasing the cooling effect of the liquid coolant. In the illustrative embodiment, negative pressure is applied to a coolant loop of the liquid coolant, which provides several advantages such as being resistant to leaks. In another embodiments, jet holes in a water block create jets of liquid coolant that are directed toward other jets of liquid coolant, which also increases the cooling effect of the liquid coolant. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213347 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/4336 (20130101) Original (OR) Class H01L 25/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242394 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Jeehwan Kim (Cambridge, Massachusetts); Hyunseong Kum (Cambridge, Massachusetts); Chang-beom Eom (Madison, Wisconsin); Hyungwoo Lee (Suwon-si, South Korea); Shane Lindemann (Madison, Wisconsin) |
| ABSTRACT | Magnetoelectric heterostructures, and related articles, systems, and methods, are generally described. |
| FILED | Friday, December 04, 2020 |
| APPL NO | 17/111623 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/12 (20130101) Original (OR) Class H01L 41/47 (20130101) H01L 41/083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242552 | Nagulu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Nagulu (New York, New York); Harish Krishnaswamy (New York, New York) |
| ABSTRACT | A circulator, comprising: a gyrator having a first side (1S) and a second side (2S) connected to a third port; a first transmission line section (TLS) having a 1 S connected to the 1 S of the gyrator and a 2S connected to a first port; a second TLS having a 1S connected to the first port and having a 2S connected to a second port; a third TLS having a 1S connected to the second port and having a 2S connected to the third port; a first cancellation path (CP) that is connected between the first port and the third port and introduces a current that is 90 degrees out of phase with a first voltage at the first port; and a second CP that is connected between the second port and the third port and introduces a current that is orthogonal to the current introduces by the first CP. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 17/255679 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/397 (20130101) Original (OR) Class Demodulation or Transference of Modulation From One Carrier to Another H03D 7/1458 (20130101) H03D 7/1466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242606 | Sepulveda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Abdon E. Sepulveda (Los Angeles, California); Gregory P. Carman (Los Angeles, California); Jinzhao Hu (Los Angeles, California); Joseph Devin Schneider (Los Angeles, California); Elmer Wu (Rowland Heights, California); Zhi Yao (Los Angeles, California); Sidhant Tiwari (Riverside, California); Wenzhong Yan (Los Angeles, California) |
| ABSTRACT | A multiferroic antenna apparatus and method are described which provides increased energy efficiencies and ease of implementation. Magnetoelastic and/or magnetostrictive resonator are coupled to a piezoelectric substrate, along with electrodes coupled to its opposing surfaces. In receive mode the resonators create mechanical waves in response to being excited into magnetic oscillation by receiving electromagnetic radiation, and these mechanical waves coupled to the piezoelectric substrate causing it to generate an electrical output signal at said electrodes. In transmit mode an electrical signal coupled through the electrodes induces mechanical waves in the piezoelectric substrate directed to the resonators which are excited into magnetic oscillation to output electromagnetic waves. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/168048 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/44 (20130101) H01Q 21/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242654 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongxing Tang (Orange, Connecticut); Xianwen Liu (New Haven, Connecticut); Joshua Surya (New Haven, Connecticut) |
| ABSTRACT | The present invention provides octave-spanning optical frequency combs. The octave-spanning optical frequency combs employ microresonators having improved stability using a smaller form factor. In some embodiments, the octave-spanning optical frequency combs are fabricated using aluminum nitride (AlN). AlN is a more robust Kerr material for generating octave-spanning soliton comb (e.g., 1.5 octaves or more). |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166411 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) G02F 2203/17 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1608 (20130101) H01S 3/06716 (20130101) H01S 3/06754 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210243146 | Leveille et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jamie Blaine Leveille (Kennebunk, Maine); Thomas James Tabb (Portsmouth, New Hampshire) |
| ABSTRACT | The present invention relates to a scanning tool for text transmissions which identifies potentially sensitive text. In exemplary embodiments, a guardian application scans regular email (and calendar appointments) subject, message body, and attachments for key words that identify if a document is potentially sensitive and it notifies the user with specifics if key words are found. If the guardian application cannot scan (either an image or a document with text that cannot be scanned), it notifies the user, requests them to open and review the document, and requires the user to select if they have or have not reviewed the document. It will not send the email if the user selects that they have not reviewed the document. |
| FILED | Monday, October 05, 2020 |
| APPL NO | 17/063202 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/04842 (20130101) G06F 16/383 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 51/12 (20130101) Original (OR) Class H04L 51/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210243212 | BOWMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin BOWMAN (Kensington, Maryland); Craig LAPRADE (Fairfax, Virginia); H. Howie Huang (McLean, Virginia) |
| ABSTRACT | A system includes a log receiving module, an authentication graph module, a sampling module, an embedding module, a training module, a link prediction module, and an anomaly detection module. The log receiving module is configured to receive a first plurality of network-level authentication logs. The authentication graph module is configured to generate an authentication graph. The sampling module is configured to generate a plurality of sequences. The embedding module is configured to tune a plurality of node embeddings according to the plurality of sequences. The training module is configured to train a link predictor according to the plurality of node embeddings and ground-truth edge information from the authentication graph. The link prediction module is configured to apply the link predictor to performs a link prediction. The anomaly detection module is configured to perform anomaly detection according to the link prediction. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 16/915183 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0876 (20130101) H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210243877 | Black et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Adam Black (Annandale, Virginia); Mark Bashkansky (Alexandria, Virginia); Charles Fancher (Fairfax, Virginia); Jonathan Kwolek (Arlington, Virginia) |
| ABSTRACT | Method and apparatus for producing a cooled atom beam suitable for use applications requiring cold atoms. A two-stage cooling process is employed in which the atoms in the atom beam are cooled in two, spatially separated regions of a cooling apparatus, wherein the atoms are first cooled in two dimensions by two counterpropagating laser beams under a magnetic field and then are cooled in three dimensions by means of an optical molasses, where the power, frequency, and magnetic fields are tuned to obtain a continuous beam of three-dimensionally cooled atoms having a controllable velocity distribution, very low decoherence, and low background atomic gas loss. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160564 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/283 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0071 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210236032 | PARK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chung Hyuk PARK (Falls Church, Virginia); Hifza Javed (McLean, Virginia) |
| ABSTRACT | The disclosed system uses facial expressions and upper body movement patterns to detect autism spectrum disorder. Emotionally expressive robots participate in sensory experiences by reacting to stimuli designed to resemble typical everyday experiences, such as uncontrolled sounds and light or tactile contact with different textures. The robot-child interactions elicit social engagement from the children, which is captured by a camera. A convolutional neural network, which has been trained to evaluate multimodal behavioral data collected during those robot-child interactions, identifies children that are at risk for autism spectrum disorder. Because the robot-assisted framework effectively engages the participants and models behaviors in ways that are easily interpreted by the participants, the disclosed system may also be used to teach children with autism spectrum disorder to communicate their feelings about discomforting sensory stimulation (as modeled by the robots) instead of allowing uncomfortable experiences to escalate into extreme negative reactions (e.g., tantrums or meltdowns). |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159691 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/16 (20130101) Original (OR) Class A61B 5/0077 (20130101) A61B 5/1128 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 2021/0016 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236328 | POPIELARSKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thermaquil, Inc. (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Thermaquil, Inc. (Philadelphia, Pennsylvania); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stephen R. POPIELARSKI (Devon, Pennsylvania); Changfeng TAI (Wexford, Pennsylvania); Grant M. CHAPMAN (Indianapolis, Indiana) |
| ABSTRACT | Embodiments disclosed include systems, methods, and apparatuses, directed to administering thermal neural modulation to mammalian tissue to control nerve conduction. Embodiments disclosed include an apparatus comprising a thermal energy source, a first heat exchanger coupled to the thermal energy source and configured to receive thermal energy therefrom, a thermal applicator configured to be disposed and secured to the anatomy of a subject having a nerve therein, in contact with the skin on the anatomy and overlying a treatment portion of the nerve, the thermal applicator configured to transfer thermal energy to the skin to raise the temperature of the treatment portion of the nerve above a physiologic temperature, a second heat exchanger is coupled to the thermal applicator and configured to transfer thermal energy thereto, and a fluid conduit having a first portion coupled to the first heat exchanger and a second portion coupled to the second heat exchanger. The fluid conduit is configured to have fluid circulated therethrough to convey thermal energy from the thermal energy source via the first heat exchanger and to the thermal applicator via the second energy at a temperature. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127431 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/007 (20130101) Original (OR) Class A61F 7/0085 (20130101) A61F 2007/0007 (20130101) A61F 2007/0054 (20130101) A61F 2007/0056 (20130101) A61F 2007/0071 (20130101) A61F 2007/0075 (20130101) A61F 2007/0086 (20130101) A61F 2007/0096 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/403 (20130101) A61N 5/025 (20130101) A61N 5/0622 (20130101) A61N 5/0625 (20130101) A61N 2005/0659 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236386 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Huang (Gainesville, Florida); Yifei Jin (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230527 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 3/07 (20130101) A61J 3/074 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 9/4808 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/3086 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 81/3216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236415 | Marx et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vanessa M. Marx (Pasadena, California); Robert H. Grubbs (South Pasadena, California) |
| ABSTRACT | The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further includes pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/079381 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/12 (20130101) A61K 9/107 (20130101) A61K 9/1075 (20130101) A61K 31/663 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/02 (20130101) A61N 7/02 (20130101) A61N 2007/0004 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 41/12 (20130101) C07B 43/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236651 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Shunzhi Wang (Evanston, Illinois) |
| ABSTRACT | The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same. |
| FILED | Friday, July 13, 2018 |
| APPL NO | 16/629686 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) A61K 47/549 (20170801) A61K 47/6929 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236688 | Wagner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Ri.MED Foundation (Palermo, Italy); University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Wagner (Gibsonia, Pennsylvania); Antonio D'Amore (Pittsburgh, Pennsylvania); Vesselin N. Shanov (Cincinnati, Ohio) |
| ABSTRACT | Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion. |
| FILED | Thursday, April 25, 2019 |
| APPL NO | 17/050538 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2415 (20130101) A61F 2/2418 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/34 (20130101) A61L 27/047 (20130101) Original (OR) Class A61L 27/58 (20130101) A61L 33/0023 (20130101) A61L 33/068 (20130101) Compositions of Macromolecular Compounds C08L 65/04 (20130101) C08L 75/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236697 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Huang (Gainesville, Florida); Kaidong Song (Gainesville, Florida); Ashley M. Compaan (Gainesville, Florida); Wenxuan Chai (Gainesville, Florida) |
| ABSTRACT | Described herein are injectable composite inks composed of a hydrogel continuous phase with a plurality of microgels present within the hydrogel continuous phase. The inks described herein have unique chemical and physical properties that enable them to be printed into a number of different types of articles. The articles produced by the injectable composite inks have numerous medical applications. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150038 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class A61L 27/222 (20130101) A61L 27/3687 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236845 | Ng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi-Ren Ng (Berkeley, California); Austin Roorda (Berkeley, California); Brian Schmidt (Berkeley, California); Utkarsh Singhal (Berkeley, California) |
| ABSTRACT | According to various embodiments of the invention, systems and methods for stimulating the retina are presented, by a combination of some or all of the following: imaging and mapping the retina; determining or assigning parameters on the retinal map, including real and virtual cell types and properties; tracking the head and/or eye; receiving or creating, transforming and/or projecting desired image signal onto the retinal map; combining the desired image with retinal parameter map data in order to determine per-cell or per-retinal-location stimulus values; and delivering the desired stimulus values to the retina. According to various embodiments of the invention, improved or novel color display, vision and perception are achieved: color gamut that encompasses the full human gamut; gamut that goes beyond the full human gamut; providing trichromatic vision functionality and/or color perception to dichromats, monochromats and/or individuals with anomalous color vision; providing perception of N-dimensional color, where N is higher than 3. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235627 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 5/0622 (20130101) Original (OR) Class A61N 2005/067 (20130101) A61N 2005/0661 (20130101) A61N 2005/0663 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236999 | Asatekin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ayse Asatekin (Arlington, Massachusetts); IIIN Sadeghi (Arlington, Massachusetts) |
| ABSTRACT | Disclosed is a nanoporous membrane including a porous support layer and a selective layer. The selective layer, being deposited on a surface of the porous support layer, has an effective pore size smaller than that of the porous support layer and contains an array of polymeric nanoparticles that have on their surfaces a plurality of —C(═O)XR groups. Also disclosed are methods of fabricating a nanoporous membrane described above and using the nanoporous membrane for separating a mixture that contains two solutes. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/050665 |
| CURRENT CPC | Separation B01D 67/0093 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 71/32 (20130101) B01D 71/40 (20130101) B01D 71/82 (20130101) B01D 2323/36 (20130101) B01D 2323/38 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237340 | HUANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong HUANG (Gainesville, Florida); Marc SOLE GRAS (Gainesville, Florida); Bing REN (Gainesville, Florida) |
| ABSTRACT | A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures, without use of a support bath, and the like. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed (e.g., continuously printed using a moving dispensing nozzle) in air without the use of supports (e.g., without the use of a support bath, a concurrently printed support posts, or the like) while a nebulized coagulation agent is dispersed alongside the printed polymer solution to at least partially coagulate the polymer solution and form an intermediate article. The self-supporting intermediate article may then be immersed in a post-printing coagulation solution to remove some or all of the remaining solvent, causing the build material to fully solidify to form a finished article from the intermediate article. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 16/781336 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/112 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237972 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (NEW BRUNSWICK, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guohong Li (Highland Park, New Jersey); Eva Y. Andrei (Highland Park, New Jersey) |
| ABSTRACT | A system for transferring objects into a device inside a controlled environment includes a winch, tool and carousel. The winch includes a drum, and wire arrangement configured to be reversibly wound onto the drum by a first drive. The tool is suspended below a distal end of the wire arrangement and configured to suspend an object. Both the tool and the object are sized to fit inside a device located below the winch. The carousel is connected to a second drive configured to rotate the carousel around a vertical axis, and includes a storage space centered at a first horizontal angle and a pass-through opening at a different second horizontal angle. The pass¬through opening being large enough to pass the tool and the object as the wire arrangement is unwound from the drum thereby lowering the tool and object inside the device. |
| FILED | Wednesday, April 17, 2019 |
| APPL NO | 15/733768 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/045 (20130101) B65G 1/0464 (20130101) Original (OR) Class Cranes; Load-engaging Elements or Devices for Cranes, Capstans, Winches, or Tackles B66C 1/24 (20130101) Capstans; Winches; Tackles, e.g Pulley Blocks; Hoists B66D 1/26 (20130101) Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238001 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon LEE (Wynnewood, Pennsylvania); Kathleen STEBE (Penn Valley, Pennsylvania); Shu YANG (Blue Bell, Pennsylvania); Xu ZHANG (Claymont, Delaware) |
| ABSTRACT | Provided are systems and methods for inducing strain fields to give rise to controllable wrinkle patterns in a variety of substrates. Also provided are articles having persistent wrinkling patterns thereon. |
| FILED | Friday, May 24, 2019 |
| APPL NO | 17/053909 |
| CURRENT CPC | Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 37/02 (20130101) Original (OR) Class B65H 2301/51145 (20130101) B65H 2701/124 (20130101) B65H 2701/172 (20130101) B65H 2801/87 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0236 (20130101) H01L 31/02168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238134 | Toscano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Pasquale Toscano (Baltimore, Maryland); Vinayak S. Khodade (Baltimore, Maryland) |
| ABSTRACT | Alkylamine-substituted perthiocarbamates capable of controllable release of hydropersulfides (RSSH) and carbonyl sulfide (COS) and their use in treating or preventing ischemia-reperfusion injury are described. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166434 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Acyclic or Carbocyclic Compounds C07C 321/14 (20130101) C07C 333/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238202 | Khan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CLARK ATLANTA UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ishrat Khan (Marietta, Georgia); Ahmed Alzharani (Glen Allen, Virginia); Amal Al-abdulrahman (Atlanta, Georgia); Rasha Alshahrani (Abha, Saudi Arabia) |
| ABSTRACT | Disclosed are novel organoborane compositions of Formula (I), (II) or (III), wherein R1, R2, R3, R′, R″, n, n′, n″, m, m′, and m″ are defined hereinabove. Also disclosed is a method of using said compositions for electrolytic media in lithium rechargeable batteries, including lithium-ion or lithium-air rechargeable batteries. Also disclosed are compositions containing said Formula (I), (II) and (III) compounds with lithium salts, useful as electrolytic media or matrices. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238687 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) C07F 5/027 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 12/02 (20130101) H01M 12/08 (20130101) H01M 2220/20 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238352 | Pyun |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong-Chul Pyun (Tucson, Arizona) |
| ABSTRACT | Sulfur copolymers and methods of synthesizing said sulfur copolymers are described herein. Sulfur monomers copolymerize with epoxide or vinylic moieties the epoxy-functionalized styrenic comonomers to form a crosslinked network of the sulfur copolymer. Sulfur copolymers having high sulfur content are used as raw materials in 3D printing. Chalcogenide-based copolymers can utilize selenium to provide for the optical properties. Using an inverse vulcanization method, chalcogenic sulfur copolymers are used to prepare chemically stable polymer plastic materials with tunable optical and thermochemical properties. Optical substrates, such as films, waveguides, and molded (nano-, micro-) objects and lenses, are constructed from sulfur copolymers via 3D printing and are substantially transparent in the visible and infrared spectrum. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156238 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/22 (20200201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238379 | Zawko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (AUSTIN, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Zawko (Austin, Texas); Christine Schmidt (Gainesville, Florida) |
| ABSTRACT | The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231653 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/0023 (20130101) A61L 26/0095 (20130101) A61L 27/52 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) Polysaccharides; Derivatives Thereof C08B 37/003 (20130101) C08B 37/0015 (20130101) C08B 37/0045 (20130101) C08B 37/0072 (20130101) C08B 37/0075 (20130101) C08B 37/0084 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/26 (20130101) C08J 3/28 (20130101) C08J 3/075 (20130101) C08J 3/242 (20130101) C08J 5/10 (20130101) C08J 5/18 (20130101) C08J 9/26 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/21 (20130101) C08K 5/0025 (20130101) C08K 5/0083 (20130101) Compositions of Macromolecular Compounds C08L 5/00 (20130101) C08L 5/04 (20130101) C08L 5/10 (20130101) C08L 5/16 (20130101) C08L 89/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238524 | Balachandran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| INVENTOR(S) | Kartik Balachandran (Fayetteville, Arkansas); Nasya Moriah Sturdivant (Raleigh, North Carolina) |
| ABSTRACT | The present invention provides elastic assemblies used to model tissues or organs of interest. In one embodiment, detailed herein, the assemblies are designed to model the blood brain barrier following a traumatic brain injury. The present invention also provides elastic membranes on which the assemblies are built, kits from which the assemblies may be prepared, and systems that expand upon the assemblies, forming more physiologically relevant models. Methods for making and using the disclosed devices are also provided. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/145030 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/34 (20130101) Original (OR) Class C12M 29/04 (20130101) C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) C12N 5/0697 (20130101) C12N 2502/08 (20130101) C12N 2502/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238541 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Bumsoo Han (West Lafayette, Indiana); George Tsu-Chih Chiu (West Lafayette, Indiana); Cih Cheng (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a novel method for rapid preparation of three dimensional (3D) spheroids/organoids, and the 3D spheroids/organoids prepared by the novel method. |
| FILED | Tuesday, December 01, 2020 |
| APPL NO | 17/108009 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 5/0663 (20130101) C12N 5/0693 (20130101) C12N 5/0697 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238615 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbo Ma (Riverside, California); Tung Kuan (Riverside, California) |
| ABSTRACT | Plants having reduced susceptibility to Phytophthora from modifying or knocking out a native PP2A subunit A. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/777023 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) C12N 15/8218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238622 | EVANS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew EVANS (Stanford, California); Yongxian LU (Palo Alto, California); Samuel HOKIN (Sante Fe, New Mexico); Jerry KERMICLE (Madison, Wisconsin) |
| ABSTRACT | The present disclosure relates to plant reproductive barriers such as those conferred by the Teosinte crossing barrier 1-female (Tcb1-female) gene, the Teosinte crossing barrier 1-male (Tcb1-male) gene, the gametophytic factor2 female (GA2-female) gene, and the gametophytic factor2 male (GA2-male) gene. The disclosure provides compositions that contain nucleic acid(s) comprising Tcb1-female, Tcb1-male, GA2-female, and/or GA2-male nucleic acid sequences, such as expression cassettes, vectors, transformed host cells, and genetically engineered plants and uses of these compositions that include for example, controlling plant pollination and overcoming species pollination barriers, conferring cross-incompatibility and self-incompatibility in plants, and isolating a breeding population of plants, such as a genetically modified plant population. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119133 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239523 | DANTUS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Marcos DANTUS (Okemos, Michigan) |
| ABSTRACT | A system for determining a characteristic of a laser includes a collection housing receiving a laser beam comprising a first pulse, a second pulse and a time period between the first pulse and the second pulse. A photon counting detector receives photons from the laser beam disposed to generate photon signals from the laser beam and generating a start signal. A fast diode generates a stop signal to provide a time reference of counted photons ns. A controller is coupled to the photon counting detector and the fast diode. The controller counts photons from the photon counting detector occurring during the time period between the first and second pulse and generates a first output signal corresponding to a power during the time period between the first pulse and the second pulse. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154461 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/4257 (20130101) Original (OR) Class G01J 2001/4247 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/11 (20130101) H01S 3/06716 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239526 | Kita et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Derek Kita (Cambridge, Massachusetts); Carlos Andres Rios Ocampo (Cambridge, Massachusetts); Juejun Hu (Newton, Massachusetts) |
| ABSTRACT | We disclose an on-chip photonic spectroscopy system capable of dramatically improving the signal-to-noise ratio (SNR), dynamic range, and reconstruction quality of Fourier transform spectrometers. Secondly, we disclose a system of components that makes up a complete on-chip RF spectrum analyzer with low-cost and high-performance. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227440 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/45 (20130101) G01J 3/0205 (20130101) G01J 3/0256 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239548 | Degraff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida); Institut National Des Sciences Appliquees De Lyon (Villeurbanne cedex, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua H. Degraff (Tallahassee, Florida); Pierre-Jean Cottinet (Villeurbanne, France); Zhiyong Liang (Tallahassee, Florida) |
| ABSTRACT | Sensors that include carbon nanotubes, and articles that include the sensors. The sensors may include a buckypaper. The sensors may be flexible. Methods of making sensors, which may include printing an electrode on a substrate. The printing of an electrode may be achieved with an inkjet printer. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 17/053147 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1114 (20130101) A61B 5/6806 (20130101) A61B 2562/125 (20130101) A61B 2562/0261 (20130101) A61B 2562/0285 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/18 (20130101) G01L 1/2262 (20130101) G01L 1/2293 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239602 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Darren Yang (Cambridge, Massachusetts); Andrew Ward (Boston, Massachusetts); Wesley Philip Wong (Cambridge, Massachusetts); Kenneth Anders Halvorsen (Glenmont, New York) |
| ABSTRACT | An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167847 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 21/07 (20130101) Original (OR) Class G01N 33/53 (20130101) G01N 33/543 (20130101) G01N 33/557 (20130101) G01N 2015/0038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239612 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Juan Jose FARIA BRICENO (Albuquerque, New Mexico); Ruichao ZHU (Albuquerque, New Mexico) |
| ABSTRACT | A system for measuring a periodic array of structures on a sample is provided. The system includes an optical source configured to produce an optical beam; an optical system configured to control the polarization of the optical beam and to focus the optical beam with a first NA1 on a sample surface and to sweep the angle of incidence across a range of angles with an approximately fixed focal position on a sample surface with a second NA2 wherein NA2>NA1; additional optical components configured to receive the optical beam reflected from the sample surface and to focus the reflected beam onto a detector; and a recording system to record the reflectivity of the sample surface as a function of the angle of incidence. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/053585 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) Original (OR) Class G01N 2021/4723 (20130101) G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240866 | MISHRA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PRABHAT KUMAR MISHRA (GAINESVILLE, Florida); YANGDI LYU (GAINESVILLE, Florida) |
| ABSTRACT | The present disclosure describes various embodiments of systems, apparatuses, and methods for detecting a Trojan inserted integrated circuit design using delay-based side channel analysis. In one such embodiment, an automated test generation algorithm produces test patterns that are likely to activate trigger conditions and change critical paths of an integrated circuit design. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085213 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/76 (20130101) Original (OR) Class G06F 21/566 (20130101) G06F 30/3308 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240891 | Karimoddini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina Agricultural and Technical State University (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Karimoddini (Greensboro, North Carolina); Solomon Grebreyohannes (Greensboro, North Carolina); Abdollah Homaifar (Greensboro, North Carolina) |
| ABSTRACT | Methods and systems for virtually testing an autonomous vehicle. In some examples, a method includes receiving status reports from a simulated system of the autonomous vehicle for each of a number of simulated scenes. The method uses a fuzzy approximate reasoning to take system and environmental conditions into consideration to evaluate if mismatches with truth data are reasonable or not. The method includes outputting test results for the system of the autonomous vehicle by, for each of the simulated scenes, performing operations comprising: fuzzifying status parameters from the status report for the simulated scene into fuzzy input parameters; mapping the fuzzy input parameters through a set of rules for the system of the autonomous vehicle into fuzzy output parameters; and mapping the fuzzy output parameters into one or more crisp test result outputs. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/148909 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 50/045 (20130101) Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) G06K 9/6262 (20130101) G06K 2209/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241066 | Hill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clinc, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parker Hill (Ann Arbor, Michigan); Jason Mars (Ann Arbor, Michigan); Lingjia Tang (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan); Johann Hauswald (Ann Arbor, Michigan); Yiping Kang (Ann Arbor, Michigan); Yunqi Zhang (Ann Arbor, Michigan) |
| ABSTRACT | A system and method of configuring a graphical control structure for controlling a machine learning-based automated dialogue system includes configuring a root dialogue classification node that performs a dialogue intent classification task for utterance data input; configuring a plurality of distinct dialogue state classification nodes that are arranged downstream of the root dialogue classification node; configuring a graphical edge connection between the root dialogue classification node and the plurality of distinct state dialogue classification nodes that graphically connects each of the plurality of distinct state dialogue classification nodes to the root dialogue classification node, wherein (i) the root dialogue classification node, (ii) the plurality of distinct classification nodes, (iii) and the transition edge connections define a graphical dialogue system control structure that governs an active dialogue between a user and the machine learning-based automated dialogue system. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/149786 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/3329 (20190101) G06F 40/30 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 3/006 (20130101) Original (OR) Class G06N 5/04 (20130101) G06N 20/00 (20190101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/1815 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242355 | Kotru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sushma Kotru (Tuscaloosa, Alabama); Vaishali Batra (Tuscaloosa, Alabama) |
| ABSTRACT | Embodiments disclosed herein facilitates the monitoring of direct ultraviolet B (UVB) radiation exposure by a person via a system having a sensor (such as Lanthanum doped lead zirconate titanate (PLZT) thin-film sensors or other ferroelectric-based sensors) sensitive to UVB radiation. The system beneficially provides current real-time dosage information associated with Vitamin D production by the person as well as real-time indication of safe exposure and/or harmful exposure to current UVB radiation conditions while also, in some embodiments, takes into consideration a person's age, skin type and sensitivity, body surface area exposed. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/151781 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/44 (20130101) G01J 1/0219 (20130101) G01J 1/0238 (20130101) G01J 1/429 (20130101) G01J 5/10 (20130101) G01J 5/34 (20130101) G01J 5/046 (20130101) G01J 2001/0257 (20130101) G01J 2001/446 (20130101) G01J 2001/4266 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/09 (20130101) H01L 31/032 (20130101) Original (OR) Class H01L 31/108 (20130101) H01L 31/109 (20130101) H01L 31/0465 (20141201) H01L 31/022475 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242357 | GAMELIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Daniel R. GAMELIN (Seattle, Washington); Daniel M. KROUPA (Seattle, Washington); Tyler J. MILSTEIN (Seattle, Washington); Sidney E. CREUTZ (Seattle, Washington); Matthew J. CRANE (Seattle, Washington); Joo Yeon ROH (Seattle, Washington) |
| ABSTRACT | Compositions of matter, downconversion layers including the compositions of matter, and devices including the compositions of matter are described. In an embodiment, the compositions of matter are downconversion materials configured to absorb a quantum of energy of a first energy and, in response, emit two or more quanta of energy of a second energy less than the first energy. Methods of making and depositing downconversion materials are also described. Downconversion precursor mixtures suitable for making downconversion materials and methods of making the same are also described. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 15/733769 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7773 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/18 (20130101) H01L 31/055 (20130101) Original (OR) Class H01L 31/02168 (20130101) H01L 33/502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242395 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weigang Wang (Tucson, Arizona); Ty A. Newhouse-Illige (Tucson, Arizona); Shufeng Zhang (Tucson, Arizona); Yihong Cheng (Tucson, Arizona); Meng Xu (Tucson, Arizona); Pravin Khanal (Tucson, Arizona) |
| ABSTRACT | Advanced magnetic tunneling junctions (MTJs) that dramatically reduce power consumption (switching energy, ESW) while maintaining a reasonably high tunneling magnetoresistance (on/off ratio, TMR) and strong thermal stability at room temperature are described herein. The MTJs include a magnetic insulator, such as an antiferromagnetice material, as the tunnel barrier. A more energy efficient switching in the MTJs is achieved by exchange bias switching (EB) due to the magnetoelectric effect (ME) or by magnon assisted switching. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/051680 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/02 (20130101) Original (OR) Class H01L 43/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242514 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hailong Chen (Atlanta, Georgia); Xuetian Ma (Atlanta, Georgia); Yuanzhi Tang (Atlanta, Georgia); Shan Xiong (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are systems and methods that can present low-temperature recycling of rare metals from spent electrodes. An exemplary method of recycling a battery comprises: mixing, in a solution, at least an electrode material and a first solvent; reducing the electrode material in the solution to create a metallic material; and extracting the metallic material from the solution. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 17/048981 |
| CURRENT CPC | Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 15/08 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 7/006 (20130101) C22B 23/0453 (20130101) C22B 26/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242606 | Sepulveda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Abdon E. Sepulveda (Los Angeles, California); Gregory P. Carman (Los Angeles, California); Jinzhao Hu (Los Angeles, California); Joseph Devin Schneider (Los Angeles, California); Elmer Wu (Rowland Heights, California); Zhi Yao (Los Angeles, California); Sidhant Tiwari (Riverside, California); Wenzhong Yan (Los Angeles, California) |
| ABSTRACT | A multiferroic antenna apparatus and method are described which provides increased energy efficiencies and ease of implementation. Magnetoelastic and/or magnetostrictive resonator are coupled to a piezoelectric substrate, along with electrodes coupled to its opposing surfaces. In receive mode the resonators create mechanical waves in response to being excited into magnetic oscillation by receiving electromagnetic radiation, and these mechanical waves coupled to the piezoelectric substrate causing it to generate an electrical output signal at said electrodes. In transmit mode an electrical signal coupled through the electrodes induces mechanical waves in the piezoelectric substrate directed to the resonators which are excited into magnetic oscillation to output electromagnetic waves. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/168048 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/44 (20130101) H01Q 21/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242680 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei Wang (Knoxville, Tennessee); Leon M. Tolbert (Knoxville, Tennessee); Yiwei Ma (Knoxville, Tennessee); Kevin Louis Tomsovic (Knoxville, Tennessee); Kai Sun (Knoxville, Tennessee); Shuoting Zhang (Knoxville, Tennessee); Jingxin Wang (Knoxville, Tennessee); Bo Liu (Knoxville, Tennessee) |
| ABSTRACT | A system includes a controller that is configured to generate a node control signal and a plurality of switch control signals, a plurality of programmable emulators, each of the plurality of programmable emulators being configurable as one of a plurality of node types responsive to the node control signal, and a plurality of switches that are programmable to couple ones of the plurality of programmable emulators to each other responsive to the plurality of switch control signals. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234230 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/041 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/00 (20130101) Original (OR) Class H02J 3/36 (20130101) H02J 3/38 (20130101) H02J 2203/20 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/537 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210243212 | BOWMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin BOWMAN (Kensington, Maryland); Craig LAPRADE (Fairfax, Virginia); H. Howie Huang (McLean, Virginia) |
| ABSTRACT | A system includes a log receiving module, an authentication graph module, a sampling module, an embedding module, a training module, a link prediction module, and an anomaly detection module. The log receiving module is configured to receive a first plurality of network-level authentication logs. The authentication graph module is configured to generate an authentication graph. The sampling module is configured to generate a plurality of sequences. The embedding module is configured to tune a plurality of node embeddings according to the plurality of sequences. The training module is configured to train a link predictor according to the plurality of node embeddings and ground-truth edge information from the authentication graph. The link prediction module is configured to apply the link predictor to performs a link prediction. The anomaly detection module is configured to perform anomaly detection according to the link prediction. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 16/915183 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/0876 (20130101) H04L 63/1425 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210237025 | TeGrotenhuis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ward E. TeGrotenhuis (Richland, Washington); Paul H. Humble (Richland, Washington); Christopher K. Clayton (Richland, Washington); Timothy G. Veldman (Richland, Washington); Robert S. Wegeng (Richland, Washington); Richard F. Zheng (Richland, Washington) |
| ABSTRACT | Chemical processors are configured to reduce mass, work in conjunction with solar concentrators, and/or house porous inserts in microchannel or mesochannel devices made by additive manufacturing. Methods of making chemical processors containing porous inserts by additive manufacturing are also disclosed. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222947 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0093 (20130101) B01J 19/248 (20130101) Original (OR) Class B01J 19/2415 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 7/08 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237041 | Viswanathan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tito Viswanathan (Little Rock, Arkansas) |
| ABSTRACT | A composite is synthesized by pyrolysis of a mixture of tannin and melamine. The synthesis process comprises dissolving the tannin and the melamine in water to form a homogeneous solution; evaporating the solution to yield a dry solid; and subjecting powders of the dry solid to a heat treatment at a temperature for a duration of time effective to produce the composite. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/152922 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 27/14 (20130101) B01J 27/24 (20130101) Original (OR) Class B01J 35/004 (20130101) B01J 37/084 (20130101) B01J 37/0236 (20130101) B01J 37/346 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/725 (20130101) C02F 2101/30 (20130101) C02F 2305/10 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/55 (20210101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237344 | Worsley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Xiaoyu Zheng (Livermore, California); Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Marcus A. Worsley (Livermore, California); Xiaoyu Zheng (Livermore, California); Patrick G. Campbell (Livermore, California); Eric Duoss (Livermore, California); James Oakdale (Livermore, California); Christopher Spadaccini (Livermore, California); Ryan Hensleigh (Livermore, California) |
| ABSTRACT | Disclosed here is a method for making a three-dimensional micro-architected aerogel, comprising: (a) curing a reaction mixture comprising a co-sol-gel material (e.g., graphene oxide (GO)) and at least one catalyst to obtain a crosslinked co-sol-gel (e.g., GO hydrogel); (b) providing a photoresin comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of the crosslinked co-sol-gel (e.g., GO hydrogel); (c) curing the photoresin using projection microstereolithography layer-by-layer to produce a wet gel having a pre-designed three-dimensional structure; (d) drying the wet gel to produce a dry gel; and (e) pyrolyzing the dry gel to produce a three-dimensional micro-architected aerogel (e.g., graphene aerogel). Also disclosed is a photoresin for projection microstereolithography, comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of a crosslinked co-sol-gel. |
| FILED | Friday, April 05, 2019 |
| APPL NO | 17/049934 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0091 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/124 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0061 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) C01B 32/198 (20170801) C01B 2204/22 (20130101) C01B 2204/26 (20130101) C01B 2204/32 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2006/10 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 283/065 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/286 (20130101) C08J 2205/026 (20130101) C08J 2333/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/042 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238051 | O'Hara |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Matthew J. O'Hara (Richland, Washington) |
| ABSTRACT | Systems and methods for separating Y and Sr are provided. The systems and methods provide combinations of solutions, vessels, and/or media that can provide Y solutions of industrially beneficial concentration. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 16/780397 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 11/005 (20130101) C01F 17/17 (20200101) Original (OR) Class Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/003 (20130101) C01G 49/0009 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 26/20 (20130101) C22B 61/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238212 | Derrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Jeffrey S. Derrick (Oakland, California); Matthias Loipersberger (Berkeley, California); Jeffrey R. Long (Lafayette, California); Martin Head-Gordon (Berkeley, California); Christopher J. Chang (Lafayette, California) |
| ABSTRACT | The electrochemical carbon dioxide reduction reaction (CO2RR) provides opportunities to synthesize value-added products from this greenhouse gas in a sustainable manner. Efficient catalysts for this reaction are provided that selectively drive CO2 reduction over the thermodynamic and kinetically competitive hydrogen evolution reaction (HER) in organic or aqueous electrolytes. The catalysts are metal-polypyridyl coordination complexes of a redox non-innocent terpyridine-based pentapyridine ligand and a first-row transition metal. The metal-ligand cooperativity in [Fe(tpyPY2Me)]2+ drives the electrochemical reduction of CO2 to CO at low overpotentials with high selectivity for CO2RR (>90%). |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/164281 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/26 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238330 | MOORE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Jeffrey S. MOORE (Savoy, Illinois); Scott R. WHITE (Champaign, Illinois); Ian D. ROBERTSON (Philadelphia, Pennsylvania); Nancy R. SOTTOS (Champaign, Illinois); Jia E. AW (Champaign, Illinois) |
| ABSTRACT | The present disclosure provides a novel method of 3D printing using frontal polymerization chemistry. This method enables the printing of tough, high quality thermosets in a short time with the option of adding fiber reinforcement. As such, it facilitates fabrication of mechanically robust 3D-printed devices and structures. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149446 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/87 (20190201) B29C 48/911 (20190201) B29C 64/106 (20170801) B29C 64/118 (20170801) B29C 64/209 (20170801) B29C 70/384 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 232/08 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238529 | Abdullah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zia Abdullah (Bexley, Ohio); Michael L. Dickens (Westerville, Ohio); Micah Paul McCreery (Baltimore, Ohio); Randy L. Jones (Delaware, Ohio); Elvin Ray Beach, III (Columbus, Ohio); Jon-David S. Sears (Columbus, Ohio); Erin Suzanne Schultz (Dublin, Ohio); Stephanie Ann Smith (Columbus, Ohio); Paul E. George, II (Powell, Ohio) |
| ABSTRACT | Scalable biomaterial-based bioreactors are described. In one embodiment, the bioreactor may comprise perforated plates stacked such that the assembled bioreactor has the necessary manifolds and chambers to transport gas and liquids to a biomaterial contained within the bioreactor, and to remove the reaction products. In another embodiment, single use bioreactors are described. Methods of operating the bioreactors are also described. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230387 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/24 (20130101) C12M 23/34 (20130101) C12M 23/40 (20130101) C12M 23/44 (20130101) C12M 29/04 (20130101) Original (OR) Class C12M 41/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238621 | Daniell |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henry Daniell (Media, Pennsylvania) |
| ABSTRACT | Enzyme containing compositions and methods are disclosed which are useful for treating cellulosic materials, such as textiles. Also provided are transgenic plants expressing one or more enzymes and compositions comprising crude extracts obtained therefrom useful for the treatment of foodstuffs which are suitable for human consumption after treatment. |
| FILED | Thursday, August 22, 2019 |
| APPL NO | 17/270382 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/20 (20130101) C12N 9/88 (20130101) C12N 9/2437 (20130101) C12N 9/2494 (20130101) C12N 15/8214 (20130101) C12N 15/8246 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238729 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Qiang Li (Ames, Iowa); Xinghang Zhang (West Lafayette, Indiana); Yifan Zhang (Los Alamos, New Mexico); Sichuang Xue (West Lafayette, Indiana); Haiyan Wang (West Lafayette, Indiana); Nicholas Allen Richter (West Lafayette, Indiana) |
| ABSTRACT | A high-strength aluminum alloy coating on a metal or an alloy. The coating contains an aluminum matrix, 9R phase, fine grains in the size range of 2-100 nm, nanotwins, and at least one solute in the aluminum capable of stabilizing grains of the aluminum matrix. A method of making a high-strength aluminum alloy coating on a substrate. The method includes providing a substrate, providing at least one source for each constituent of an aluminum alloy, and depositing atoms of each constituent of the aluminum alloy from the corresponding at least one source of each constituent of the aluminum alloy on the substrate utilizing a deposition method, wherein the deposited atoms form an aluminum alloy coating containing 9R phase, fine grains, and nanotwins. |
| FILED | Monday, November 30, 2020 |
| APPL NO | 17/106964 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Alloys C22C 21/00 (20130101) C22C 2202/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/16 (20130101) Original (OR) Class C23C 14/5806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238753 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyoung-Shin Choi (Fitchburg, Wisconsin); John James Roylance (Madison, Wisconsin); Stephen R. Kubota (Madison, Wisconsin) |
| ABSTRACT | Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. Using the cells and methods, furfurals can be converted into furan alcohols or linear ketones. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231137 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/55 (20210101) C25B 3/25 (20210101) Original (OR) Class C25B 11/04 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/133 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238769 | Mane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anil U. Mane (Naperville, Illinois); Yuepeng Zhang (Naperville, Illinois); Devika Choudhury (Naperville, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Kaizhong Gao (North Oaks, Minnesota); John N. Hryn (Hawthorn Woods, Illinois) |
| ABSTRACT | Coated nanofibers and methods for forming the same. A magnetic nanofiber is formed and a barrier coating is deposited on the magnetic nanofiber by atomic layer deposition (“ALD”) process. The coated nanofiber may include a reduced magnetic nanostructure and a barrier coating comprising a first oxide coating on the nanofiber, the coating being non-reactive with the magnetic polymer nanofiber, the barrier coating have a thickness of 2 nm to 12 nm. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/776702 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/08 (20130101) C23C 16/403 (20130101) C23C 16/45525 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Original (OR) Class Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239109 | Wikswo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Wikswo (Brentwood, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky) |
| ABSTRACT | A peristaltic micropump include a plurality of channels, each channel being flexible, having a middle channel portion, and being operably in fluidic communications with a first port and a second port, and the middle channel portions of the plurality of channels being arranged in one or more concentric circles; and an actuator comprising a bearing assembly driven by a motor, the bearing assembly comprising a plurality of rolling members and a bearing accommodating member for accommodating the plurality of rolling members, the actuator being positioned in relation to the plurality of channels such that when the bearing accommodating member rotates, the plurality of rolling members rolls along the one or more concentric circles of the middle channel portions of the plurality of channels to cause individually fluids to transfer between the first port and the second port of each of the plurality of channels simultaneously at different flowrates. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269329 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 43/12 (20130101) F04B 43/0054 (20130101) F04B 43/0072 (20130101) F04B 43/1253 (20130101) F04B 43/1269 (20130101) Original (OR) Class F04B 43/1292 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239650 | Hollerbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Adam L. Hollerbach (Richland, Washington); Yehia M. Ibrahim (Richland, Washington); Sandilya V.B. Garimella (Richland, Washington) |
| ABSTRACT | Apparatus comprise an electrode arrangement comprising a plurality of electrodes defining a volume, an ion entrance, and an ion exit, and a voltage source coupled to the plurality of electrodes and configured to apply a nonlinear DC voltage sequence to the electrodes between the ion entrance and the ion exit that directs ions through the volume with the volume at a pressure of at least 1 Torr. Ions can be focused using nonlinear DC voltage sequences, including at atmospheric pressure. Related methods are also disclosed. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 16/783044 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/401 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239675 | Teepe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California); Consolidated Edison Company of New York, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Teepe (Menlo Park, California); Todd Karin (Fairfield, California); Peter Kiesel (Palo Alto, California); Ajay Raghavan (Mountain View, California); Jane Shin (New York, New York); Bradley Kittrell (New York, New York); Serena Lee (New York, New York) |
| ABSTRACT | A corrosion monitoring system includes one or more objects coupled to respective portions of a transformer tank. The one or more objects are configured to corrode before the respective portions of the transformer tank. At least one optical sensor is coupled to each of the objects. The at least one optical sensor has an optical output that changes in response to strain of the object. An analyzer is coupled to the at least one optical sensor. The analyzer is configured to perform one or more of detecting and predicting corrosion of the transformer tank based on the output of the at least one optical sensor. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151377 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/268 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/2045 (20190101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 31/62 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239779 | TURNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The MITRE Corporation (Bedford, Massachusetts); Sandia National Laboratories (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew James TURNER (Cambridge, Massachusetts); Edlyn Victoria LEVINE (Bedford, Massachusetts); Pauli KEHAYIAS (Albuquerque, New Mexico); Daniel T. WALTERS (Bedford, Massachusetts); Ronald L. WALSWORTH (Cambridge, Massachusetts); Marko LONCAR (Cambridge, Massachusetts); Nicholas Ryan LANGELLIER (Cambridge, Massachusetts) |
| ABSTRACT | Devices for determining a state of a magnetic field-generating article are provided. In various embodiments, a device comprises: a single crystal diamond having a plurality of NV centers, the single crystal diamond configured to be disposed adjacent to a magnetic field-generating article, and configured to generate a fluorescent signal in response to being illuminated by a light source; a coherent light source configured to generate a light beam directed at the single crystal diamond; a microwave (MW) radiation source configured to irradiate the single crystal diamond with a MW signal; a magnetic field source configured to apply a bias magnetic field to the single crystal diamond; a photosensor configured to collect the fluorescent signal generated by the single crystal diamond; and a computing node operatively coupled to each of the coherent light source, the MW radiation source, the magnetic field source, and the photosensor. |
| FILED | Sunday, January 31, 2021 |
| APPL NO | 17/163476 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0017 (20130101) G01R 33/389 (20130101) G01R 33/5608 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239864 | Taleyarkhan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rusi P Taleyarkhan (Lafayette, Indiana) |
| ASSIGNEE(S) | Rusi P Taleyarkhan (Lafayette, Indiana) |
| INVENTOR(S) | Rusi P Taleyarkhan (Lafayette, Indiana) |
| ABSTRACT | Systems and methods for neutron detection using tensioned metastable fluid detectors, using multi-atom spectroscopy approach. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/776512 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239893 | Di Nicola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Jean-Michel Di Nicola (Livermore, California); Alvin Erlandson (Livermore, California); Joseph A. Menapace (Livermore, California); Gabriel Mennerat (Gif-sur-Yvette, France) |
| ABSTRACT | Technology is provided to transform spatially variable arbitrary polarization states and wavefront of a high-fluence, large-aperture laser beam to prescribed spatially resolved polarization states and wavefront at a specific position, with minimal losses. Technology is also provided to transform spatially resolved polarization states and wavefront at a specific position to spatially variable arbitrary polarization states and wavefront. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/009029 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210240894 | Kimura et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (, None) |
| INVENTOR(S) | Adam G. Kimura (Westerville, Ohio); Andrew S. Elliott (Columbus, Ohio); Daniel A. Perkins (Lewis Center, Ohio) |
| ABSTRACT | A Register Transfer Level (RTL) representation is recovered from a netlist representing an integrated circuit (IC). The netlist is converted to a graph comprising nodes belonging to a set of node types and edges connecting the nodes. The set of node types includes an instance node type representing an electronic component and a wire node type representing signal transfer between components. The graph is converted to a standardized graph by replacing subgraphs of the graph with standardized subgraphs. An RTL representation of the standardized graph is generated by operations including building signal declarations in a hardware description language (HDL) from the wire nodes of the standardized graph and building signal assignments in the HDL from instance nodes of the standardized graph. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/239977 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/33 (20200101) G06F 30/327 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210241124 | Goldhahn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Alan Goldhahn (Livermore, California); Priyadip Ray (Livermore, California); Braden C. Soper (Livermore, California); Hao Chen (Boise, Idaho); Deepak Rajan (Livermore, California) |
| ABSTRACT | A node having a sensor and a computing device is provided for identifying a location of a source of a physical process. The node collects via the sensor a measurement of the physical process. The node repeatedly recalculates parameters until termination criterion is satisfied. The node receives parameters of a probability distribution and a gradient from other nodes. The node generates parameters based on the parameters and the gradients received from the other nodes. The node samples from a distribution of source locations based on the generated parameters. The node calculates a gradient derived from the sampled source locations, the generated parameters, and a joint probability of the sampled source locations and the measurement. The node sends to a subset of other nodes the generated parameters and the calculated gradient. When the termination criterion is satisfied, the generated parameters represent the probability distribution of the source location. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165714 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/086 (20130101) G06N 3/126 (20130101) Original (OR) Class G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242003 | Yacout et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdellatif M. Yacout (Naperville, Illinois); Sumit Bhattacharya (Darien, Illinois) |
| ABSTRACT | Provided herein are thermionic converters that are capable of operating at lower temperatures and with increased efficiency as compared to conventional thermionic converters. Also provided are methods of using and making the thermionic converters of the disclosure. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 16/783105 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242281 | Fu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kai Fu (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Yuji Zhao (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Fu (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Yuji Zhao (Chandler, Arizona) |
| ABSTRACT | A switching device including a GaN substrate; an unintentionally doped GaN layer on a first surface of the GaN substrate; a regrown unintentionally doped GaN layer on the unintentionally doped GaN layer; a regrowth interface between the unintentionally doped GaN layer and the regrown unintentionally doped GaN layer; a p-GaN layer on the regrown unintentionally doped GaN layer; a first electrode on the p-GaN layer; and a second electrode on a second surface of the GaN substrate. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215282 |
| CURRENT CPC | Static Stores G11C 13/0002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2427 (20130101) Original (OR) Class H01L 29/861 (20130101) H01L 29/2003 (20130101) H01L 29/66204 (20130101) H01L 45/12 (20130101) H01L 45/1608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242482 | PAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Keji PAN (Ellicott City, Maryland); Sean R. BISHOP (Takoma Park, Maryland); Thomas LANGDO (Great Falls, Virginia); Bryan M. BLACKBURN (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keji PAN (Ellicott City, Maryland); Sean R. BISHOP (Takoma Park, Maryland); Thomas LANGDO (Great Falls, Virginia); Bryan M. BLACKBURN (Bethesda, Maryland) |
| ABSTRACT | In various embodiments, techniques for fabricating solid oxide fuel cells utilize setter plates composed of or having outer surfaces composed of materials unreactive with species found in the layers of the cell. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168357 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/126 (20130101) H01M 8/1226 (20130101) H01M 8/1253 (20130101) H01M 8/1286 (20130101) Original (OR) Class H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242487 | TEPAVCEVIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanja TEPAVCEVIC (Chicago, Illinois); Nigel Hajj BECKNELL (Glen Ellyn, Illinois); Pietro Papa LOPES (Woodridge, Illinois); Dusan STRMCNIK (Lemont, Illinois); Vojislav STAMENKOVIC (Naperville, Illinois) |
| ABSTRACT | An alternative grid energy storage system is described herein. In one embodiment, an electrochemical cell comprises a high specific surface area cathode (e.g., a cathode comprising a carbon nanofoam paper, a carbon nanotube mesh, a particulate carbon material, electrolytic manganese dioxide, or a manganese dioxide film), a zinc or lead anode (e.g., Zn or Pb foil), a selective ion-conductive separator that does not conduct zinc ions (e.g., a NAFION sulfonated tetrafluoroethylene based fluoropolymer-copolymer separator) between the anode and the cathode, and an aqueous electrolyte comprising a manganese salt (e.g., aqueous manganese sulfate) contacting the electrodes and the separator. A battery comprising two or more of the electrochemical cells electrically connected together in series, parallel, or both, also is described. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 16/778175 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/162 (20130101) H01M 4/505 (20130101) H01M 4/587 (20130101) H01M 4/622 (20130101) H01M 4/661 (20130101) H01M 4/663 (20130101) H01M 4/669 (20130101) H01M 10/054 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242488 | KUMTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | PRASHANT N. KUMTA (PITTSBURGH, Pennsylvania); PARTHA SAHA (PITTSBURGH, Pennsylvania); MONI KANCHAN DATTA (PITTSBURGH, Pennsylvania); AYYAKKANNU MANIVANNAN (MORGANTOWN, West Virginia) |
| ABSTRACT | The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g., cathodes, for use in electrochemical cells, such as rechargeable batteries. The Chevrel-phase materials have a general formula of Mo6Z8 (Z=sulfur) or Mo6Z18-yZ2y (Z1=sulfur; Z2=selenium), and partially cuprated Cu1Mo6S8 as well as partially de-cuprated Cu1-xMgxMo6S8 and the precursors have a general formula of MxMo6Z8 or MxMo6Z18-yZ2y, M=Cu. The cathode containing the Chevrel-phase material in accordance with the invention can be combined with a magnesium-containing anode and an electrolyte. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085099 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/002 (20130101) C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/006 (20130101) C01G 39/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/581 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242509 | TONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YuYe J. TONG (Gaithersburg, Maryland); Eric G. SORTE (Washington, District of Columbia) |
| ABSTRACT | Provided are batteries and fuel cells incorporating a stripline detector for use in nuclear magnetic resonance (NMR). The stripline batteries and fuel cells can be used for in situ NMR measurement of battery or fuel cell chemistry. Also provided are methods for measuring in situ battery and fuel cell NMR using the stripline batteries and fuel cells of the invention. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/145482 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/088 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/3456 (20130101) G01R 33/3628 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/587 (20130101) H01M 4/661 (20130101) H01M 4/5825 (20130101) H01M 8/04305 (20130101) H01M 10/48 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 50/411 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210243919 | Iyengar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madhusudan K. Iyengar (Woodstock, New York); Pritish R. Parida (Cortlandt, New York); Mark D. Schultz (Ossining, New York) |
| ABSTRACT | A data center cooling system has an indoor portion wherein heat is absorbed from components in the data center, and an outdoor heat exchanger portion wherein outside air is used to cool a first heat transfer fluid (e.g., water) present in at least the outdoor heat exchanger portion of the cooling system during a first mode. When an appropriate time has been reached to switch from the first mode to a second mode, the outdoor heat exchanger portion of the data cooling system is switched to a second heat transfer fluid, which is a relatively low performance heat transfer fluid (compared to the first fluid). It has a second heat transfer fluid freezing point, lower than the first heat transfer fluid freezing point, and sufficiently low to operate without freezing when the outdoor air temperature drops below a first predetermined relationship with the first heat transfer fluid freezing point. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150357 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 47/006 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/00 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/2079 (20130101) H05K 7/20836 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210235706 | Carbone |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ignazio Carbone (Raleigh, North Carolina) |
| ABSTRACT | The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MAT1-2). |
| FILED | Monday, April 29, 2019 |
| APPL NO | 17/050751 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/30 (20200101) A01N 63/34 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236579 | Arvik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SONOMACEUTICALS, LLC (Santa Rosa, California); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torey James Arvik (Santa Rosa, California); Rebecca Susan Lipson (Santa Rosa, California); Wallace H. Yokoyama (Albany, California) |
| ABSTRACT | The present disclosure relates to health benefits of Chardonnay seed products. |
| FILED | Monday, September 14, 2020 |
| APPL NO | 17/020533 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/87 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236581 | Arvik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SONOMACEUTICALS, LLC (Santa Rosa, California); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torey James Arvik (Santa Rosa, California); Hyunsook Kim (Seoul, South Korea); Wallace H. Yokoyama (Albany, California); Scott R. Forsberg (Santa Rosa, California) |
| ABSTRACT | Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 36/28 (20130101) A61K 36/79 (20130101) A61K 36/87 (20130101) Original (OR) Class A61K 36/9066 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236617 | Selvaraj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia); THE OHIO STATE UNIVERSITY (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramesh Kumar Selvaraj (Bogart, Georgia); Gabriel Akerele (Athens, Georgia); Sankar Renu (Wooster, Ohio); Renukaradhya J. Gourapura (Wooster, Ohio) |
| ABSTRACT | The present disclosure relates to nanoparticle compositions for use as vaccines against Clostridium perfringens in poultry which causes necrotic enteritis in poultry. Such compositions include one or more Clostridium perfringens extracellular proteins entrapped in a polyanhydride or chitosan nanoparticle. The one or more Clostridium perfringens extracellular proteins may include one or more Clostridium perfringens toxins, such as, for example, alpha toxin (CPA), beta toxin (CPB), epsilon toxin (ETX), iota toxin (ITX), perfringolysin O (PFO), enterotoxin (CPE), beta2 toxin (CPB2), or NetB toxin. In some aspects, the composition further includes a Salmonella enteritidis flagellar protein. The present invention also includes methods for the oral delivery of one or more Clostridium perfringens extracellular proteins to the mucosal membrane of the intestinal tract of a bird of the order Galliformes. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) Original (OR) Class A61K 2039/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238615 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenbo Ma (Riverside, California); Tung Kuan (Riverside, California) |
| ABSTRACT | Plants having reduced susceptibility to Phytophthora from modifying or knocking out a native PP2A subunit A. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/777023 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) C12N 15/8218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238617 | Tako et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); THE UNIVERSITY OF MELBOURNE (MELBOURNE, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elad Tako (BROOKTONDALE, New York); Jesse T. Beasley (NORTH MELBOURNE, Australia); Alexander Johnson (ABBOTSFORD, Australia) |
| ABSTRACT | A grain crop may have an increased amount of nicotianamine (NA). The increased NA may correlate with an increased bioavailability of iron in the grain and any product, such as ground flour, resulting from processing of the grain. The increase of NA may be achieved through the expression of the OsNAS2 gene. Further, a grain flour produced from a transformed grain plant may have an increased amount of NA, and thus an increased amount of bio-available iron, as compared to a grain flour produced from a non-transformed grain plant of the same species. The grain flour produced from the transformed grain plant (“biofortified flour”) may be used in food production for feed to animals or humans. Such a feed including the biofortified flour may improve the gut health and/or the feed efficiency of the eater as compared to the gut health for an eater of non-biofortified flour. |
| FILED | Thursday, August 06, 2020 |
| APPL NO | 16/986600 |
| CURRENT CPC | Fodder A23K 10/30 (20160501) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8243 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238619 | McMahan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colleen M. McMahan (Sausalito, California); Dante Placido (Oakland, California) |
| ABSTRACT | Altered guayule that produce more rubber than the amount of rubber produced by non-altered guayule are provided. The alterations may include (i) a reduction in amount of functional PaAos produced by the altered guayule, (ii) an increase in amount of a transcription factor produced by the altered guayule, (iii) an increase in amount of salicylic acid within the altered guayule, (iv) exposure of the altered guayule to cold temperature, and (v) a combination thereof. Methods of producing the altered guayule and methods of increasing the amount of rubber produced by a guayule are also provided. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197536 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Compositions of Macromolecular Compounds C08L 7/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/1137 (20130101) C12N 15/8218 (20130101) C12N 15/8243 (20130101) Original (OR) Class C12N 15/8251 (20130101) C12N 15/8261 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 402/01092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238622 | EVANS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Institution of Washington (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew EVANS (Stanford, California); Yongxian LU (Palo Alto, California); Samuel HOKIN (Sante Fe, New Mexico); Jerry KERMICLE (Madison, Wisconsin) |
| ABSTRACT | The present disclosure relates to plant reproductive barriers such as those conferred by the Teosinte crossing barrier 1-female (Tcb1-female) gene, the Teosinte crossing barrier 1-male (Tcb1-male) gene, the gametophytic factor2 female (GA2-female) gene, and the gametophytic factor2 male (GA2-male) gene. The disclosure provides compositions that contain nucleic acid(s) comprising Tcb1-female, Tcb1-male, GA2-female, and/or GA2-male nucleic acid sequences, such as expression cassettes, vectors, transformed host cells, and genetically engineered plants and uses of these compositions that include for example, controlling plant pollination and overcoming species pollination barriers, conferring cross-incompatibility and self-incompatibility in plants, and isolating a breeding population of plants, such as a genetically modified plant population. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119133 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238658 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Hawaii (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lena Diaz (Morrison, Colorado); Daniel McKewn Jenkins (Honolulu, Hawaii) |
| ABSTRACT | The present invention relates to delivering sample preparation technologies to enhance the performance of point-of-care agricultural diagnostics by improving the capacity to detect trace contaminations of pathogenic organisms along the entire food supply chain including pre- and post-harvest processing and distribution. Sample preparation is crucial for adequate test performance of downstream diagnostics like LAMP and supports sensitive detection of bacterial contaminates. This invention increases the speed and scale of routine pathogen surveillance and the efficacy of management response and mitigation of foodborne disease outbreaks. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/259647 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/465 (20130101) C02F 1/5263 (20130101) C02F 1/46109 (20130101) C02F 2001/46133 (20130101) C02F 2001/46171 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210236983 | Junaedi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Precision Combustion, Inc. (North Haven, Connecticut) |
| ASSIGNEE(S) | Precision Combustion, Inc. (, None) |
| INVENTOR(S) | Christian Junaedi (Cheshire, Connecticut); Codruta Maria Zoican-Loebick (North Haven, Connecticut); Kyle Hawley (Woodbury, Connecticut) |
| ABSTRACT | A first process and sorbent for removing ammonia from a gaseous environment, the sorbent comprised of graphene oxide having supported thereon at least one compound selected from metal salts, metal oxides and acids, each of which is capable of adsorbing ammonia. A second process and sorbent system for removing ammonia and a volatile organic compound from a gaseous environment; the sorbent system comprised of two graphene-based materials: (a) the aforementioned graphene oxide, and (b) a nitrogen and oxygen-functionalized graphene. The sorbents are regenerable under a pressure gradient with little or no application of heat. The processes are operable through multiple adsorption-desorption cycles and are applicable to purifying and revitalizing air contaminated with ammonia and organic compounds as may be found in spacesuits, aerospace cabins, underwater vehicles, and other confined-entry environments. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/211946 |
| CURRENT CPC | Separation B01D 53/0476 (20130101) Original (OR) Class B01D 2253/102 (20130101) B01D 2253/306 (20130101) B01D 2253/311 (20130101) B01D 2253/1122 (20130101) B01D 2253/1124 (20130101) B01D 2257/406 (20130101) B01D 2257/708 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) B01J 20/20 (20130101) B01J 20/041 (20130101) B01J 20/046 (20130101) B01J 20/0229 (20130101) B01J 20/0237 (20130101) B01J 20/0244 (20130101) B01J 20/3206 (20130101) B01J 20/3458 (20130101) B01J 20/3491 (20130101) B01J 20/28059 (20130101) B01J 20/28061 (20130101) B01J 20/28064 (20130101) B01J 20/28076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237759 | Wray et al. |
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| FUNDED BY |
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| APPLICANT(S) | Nissan North America, Inc. (Franklin, Tennessee); The University of Massachusetts (Boston, Massachusetts); United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Hollins Wray (Fremont, California); Omar Bentahar (Sunnyvale, California); Astha Vagadia (San Jose, California); Laura Cesafsky (San Francisco, California); Arec Jamgochian (Stanford, California); Stefan Witwicki (San Carlos, California); Najamuddin Mirza Baig (San Jose, California); Julius S. Gyorfi (Vernon Hills, Illinois); Shlomo Zilberstein (Amherst, Massachusetts); Sparsh Sharma (Santa Clara, California) |
| ABSTRACT | A processor is configured to execute instructions stored in a memory to determine, in response to identifying vehicle operational scenarios of a scene, an action for controlling the AV, where the action is from a selected decision component that determined the action based on level of certainty associated with a state factor; generate an explanation as to why the action was selected, such that the explanation includes respective descriptors of the action, the selected decision component, and the state factor; and display the explanation in a graphical view that includes a first graphical indicator of a world object of the selected decision component, a second graphical indicator describing the state factor, and a third graphical indicator describing the action. |
| FILED | Tuesday, March 17, 2020 |
| APPL NO | 16/821115 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 50/16 (20130101) Original (OR) Class B60W 60/0011 (20200201) B60W 2050/146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210237850 | Turner et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis L. Turner (Yorktown, Virginia); Scott E. Brynildsen (Yorktown, Virginia); John W. Mulvaney (Yorktown, Virginia); Albert R. Allen (Yorktown, Virginia); David P. Lockard (Hampton, Virginia); Craig L. Streett (Fairfax, Virginia); Mehdi R. Khorrami (Norfolk, Virginia) |
| ABSTRACT | Methods, systems and devices of the various embodiments may provide slat-cove fillers configured to reduce leading-edge slat noise on aircraft, such as transport aircraft. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222604 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/02 (20130101) B64C 9/08 (20130101) B64C 9/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210238711 | Schuh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Schuh (Wayland, Massachusetts); Christian Oliver (Cambridge, Massachusetts) |
| ABSTRACT | Molybdenum-containing alloys, and associated systems and methods, are generally described. In certain embodiments, secondary and/or tertiary elements can be included, along with molybdenum, to provide beneficial properties during the sintering of the molybdenum-containing alloy. The molybdenum-containing alloys are, according to certain embodiments, nanocrystalline. According to certain embodiments, the molybdenum-containing alloys have high relative densities. The molybdenum-containing alloys can be relatively stable, according to certain embodiments. Inventive methods for making molybdenum-containing alloys are also described herein. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/105152 |
| CURRENT CPC | Alloys C22C 1/045 (20130101) Original (OR) Class C22C 27/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210239606 | Gabrieli et al. |
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| FUNDED BY |
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| APPLICANT(S) | Andrea Gabrieli (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Gabrieli (Honolulu, Hawaii); John N. Porter (Honolulu, Hawaii) |
| ABSTRACT | The present invention relates to a computationally compact and efficient method for determining physical characteristics of remote targets of interest from hyperspectral image scenes. Ground-based as well as space-borne hyperspectral imaging in the 7-14 microns region, also known as Thermal InfraRed (TIR) Hyperspectral imaging, is assuming increasing importance in military and civilian remote sensing. However, converting large hyperspectral imaging datasets into useable data products is complex and often requires long processing times. In-situ, field and on-board TIR hyperspectral imaging data processing is desirable for immediate detection, but currently very limited. Additionally, retrieving physical information of a target, seen against a background of clouds, is currently not possible. The present method creates a way to significantly improve the efficiency of analyzing hyperspectral imaging data to retrieve characteristics of remote targets of interest in the presence of both clear and cloudy sky background conditions. The present method uses a supervised machine learning Partial Least Squares Regression (PLSR) algorithm, which was trained from a library of simulated radiative transfer spectra. The radiative transfer library included a large number of complex conditions, which are difficult to implement in traditional lookup table methods, but become amenable in the present method. This invention is computationally compact and efficient and can be employed for on-board sensor data processing on the ground and in space. Various tests have shown the efficiency and reliability of the present method. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 16/781749 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/108 (20130101) G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/3504 (20130101) Original (OR) Class G01N 2021/1795 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242281 | Fu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kai Fu (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Yuji Zhao (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Fu (Tempe, Arizona); Houqiang Fu (Tempe, Arizona); Yuji Zhao (Chandler, Arizona) |
| ABSTRACT | A switching device including a GaN substrate; an unintentionally doped GaN layer on a first surface of the GaN substrate; a regrown unintentionally doped GaN layer on the unintentionally doped GaN layer; a regrowth interface between the unintentionally doped GaN layer and the regrown unintentionally doped GaN layer; a p-GaN layer on the regrown unintentionally doped GaN layer; a first electrode on the p-GaN layer; and a second electrode on a second surface of the GaN substrate. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215282 |
| CURRENT CPC | Static Stores G11C 13/0002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/2427 (20130101) Original (OR) Class H01L 29/861 (20130101) H01L 29/2003 (20130101) H01L 29/66204 (20130101) H01L 45/12 (20130101) H01L 45/1608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210242810 | Choi et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang H. Choi (Poquoson, Virginia); Dennis M. Bushnell (Hampton, Virginia); Adam J. Duzik (Rockledge, Florida) |
| ABSTRACT | Various aspects include electric generators configured to boost electrical output by leveraging electron avalanche generated by a high energy photon radiation source. In various aspects, an electric generator includes a stator and a rotor positioned within the stator, wherein the stator and rotor are configured to generate electric current when the rotor is rotated, and a high energy photon source (e.g., a gamma ray source) positioned and configured to irradiate at least a portion of conductors in the rotor or stator. In some aspects, the stator generates a magnetic field when the electric generator is operating, and the rotor includes armature windings configured to generate electric current when the rotor is rotated. In some aspects, the high energy photon source includes cobalt-60 and/or cesium-137. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235497 |
| CURRENT CPC | Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/04 (20130101) G21H 1/12 (20130101) Electric Machines Not Otherwise Provided for H02N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210235826 | Friederich et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Challenge America (Basalt, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aidan Richard Wilhelm Friederich (Conifer, Colorado); Christopher Lee Carter (Warren, Ohio); Angela Payton (Mansfield, Ohio); Michael Christopher Tracz (Brecksville, Ohio); Emily Rose Szabo (Strongsville, Ohio); Elle Marcus (Lakewood, Ohio); Michael Fugate (Cleveland, Ohio); Jason Grenfell (Streetsboro, Ohio); Scott Rawlings (North Ridgeville, Ohio) |
| ABSTRACT | A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232320 |
| CURRENT CPC | Walking Sticks; Umbrellas; Ladies\' or Like Fans A45B 5/00 (20130101) Original (OR) Class A45B 9/02 (20130101) A45B 2009/002 (20130101) Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports F16M 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236450 | Guthrie |
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| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | O'Neil W. Guthrie (Flagstaff, Arizona) |
| ABSTRACT | The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229833 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/215 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/365 (20130101) A61K 36/74 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210236523 | SCHINDLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanuelle SCHINDLER (New Haven, Connecticut); Deepak D'SOUZA (Guilford, Connecticut) |
| ABSTRACT | A method of treating headache disorders, by administering an effective amount of a composition of a psychedelic to the individual and treating the headache disorder. A method of treating migraine headache in an individual, by adminis |