FedInvent™ Patent Applications
Application Details for Thursday, September 30, 2021
This page was updated on Friday, October 01, 2021 at 07:06 PM GMT
Department of Health and Human Services (HHS)
| US 20210298593 | Alonso et al. |
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| FUNDED BY |
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| APPLICANT(S) | Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | José-Manuel Alonso (New York, New York); Mitchell Dul (Cold Spring, New York); Hamed Rahimi Nasrabadi (Brooklyn, New York) |
| ABSTRACT | Systems for performing ON-OFF perimetry visual field tests. The systems may include a display apparatus including at least one display, and at least one computing device in electronic communication with the display apparatus. The computing device(s) may be configured to perform the ON-OFF perimetry test on a patient by performing processes including directing the patient to visual focus on an eye fixation region depicted in a visual field. The visual field may be divided into a right side and a left side. The processes performed by the computing device(s) may also include generating a plurality of stimuli in the visual field to be detected by the patient, directing the patient to indicate when the patient detects each stimulus depicted within the visual field, and analyzing the patient's indications to diagnosis a retinal disease, a visual cortex disease, and/or a deficit condition of an eye of the patient. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217553 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/024 (20130101) Original (OR) Class A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/113 (20130101) A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298606 | Kocaturk et al. |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
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| INVENTOR(S) | Ozgur Kocaturk (Rockville, Illinois); Fahrettin Levent Degertekin (Atlanta, Georgia); Yusuf S. Yaras (Atlanta, Georgia) |
| ABSTRACT | Methods are disclosed herein for measuring local E-fields, B-fields, and/or temperature effects of an MRI scan utilizing an acousto-optical sensor. A method includes positioning the acousto-optical sensor at a location of a body or phantom; receiving, with an antenna of the acousto-optical sensor, MRI RF energy localized at the first location; interrogating, with a light source, and via an optical fiber, an acousto-optical sensor region of the acousto-optical sensor; detecting, with a photodetector, interrogation light reflected from the acousto-optical sensor region; and outputting one or more signals corresponding to the detected interrogation light reflected from the acousto-optical sensor region. The one or more signals can correspond to an E-field, a B-field, and/or a temperature of the received MRI RF energy at the first location. Additional methods can include mapping results of multiple measurements around an implant. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259033 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/0097 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3206 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) G01R 33/288 (20130101) G01R 33/3692 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298618 | MUKKAMALA et al. |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); University of Maryland (College Park, Maryland) |
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| INVENTOR(S) | Ramakrishna MUKKAMALA (East Lansing, Michigan); Anand CHANDRASEKHAR (East Lansing, Michigan); Jin-Oh HAHN (Rockville, Maryland) |
| ABSTRACT | A system and method is presented for cuff-less blood pressure measurement in a mobile device. A key aspect of this disclosure is the discovery of a new location for blood pressure measurement at the fingertip of a subject and that reflectance-mode photoplethysmography can be used to help make this measurement. Through experiments in human subjects, it was discovered that it is indeed possible to measure systemic blood pressure by having a subject press the fingertip against a reflectance-mode photo-plethysmography-force sensor unit under visual guidance and then compute blood pressure from the resulting variable-amplitude blood volume oscillations and applied pressure via an oscillometric algorithm. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336739 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0261 (20130101) A61B 5/0295 (20130101) A61B 5/706 (20130101) A61B 5/743 (20130101) A61B 5/02055 (20130101) A61B 5/02141 (20130101) Original (OR) Class A61B 5/02225 (20130101) A61B 5/02416 (20130101) A61B 5/6898 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298659 | Grover et al. |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Pulkit Grover (Pittsburgh, Pennsylvania); Alireza Chamanzar (Pittsburgh, Pennsylvania); Marlene Behrmann Cohen (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel method for using the widely-used electroencephalography (EEG) systems to detect and localize silences in the brain is disclosed. The method detects the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. This method can also be used for reduced activity localization, activity level mapping throughout the brain, as well as mapping activity levels in different frequency bands. By accounting for the contributions of different sources to the power of the recorded signals, and using a hemispheric baseline approach and a convex spectral clustering framework, the method permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183545 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/372 (20210101) Original (OR) Class A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298662 | GHARAGOUZLOO et al. |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
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| INVENTOR(S) | Codi Amir GHARAGOUZLOO (Medford, Massachusetts); Craig FERRIS (Holden, Massachusetts) |
| ABSTRACT | A method of diagnosing a likelihood of onset or progression of Alzheimer's disease and related dementias (ADRD) in a subject is provided. The method requires determining vascularization changes in different regions of the brain on the basis of a quantitative cerebral blood volume (qCBV) map of the subject's brain. The qCBV is obtained from one or more quantitative ultrashort time-to-echo contrast-enhanced (QUTE-CE) MRI images of the brain. A method of treating a subject for ADRD is provided. Diagnostic markers for onset and progression of Alzheimer's disease are also provided. |
| FILED | Monday, July 29, 2019 |
| APPL NO | 17/262459 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/489 (20130101) A61B 5/4088 (20130101) Original (OR) Class A61B 5/4842 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/13 (20130101) A61K 31/27 (20130101) A61K 31/55 (20130101) A61K 31/135 (20130101) A61K 31/138 (20130101) A61K 31/343 (20130101) A61K 31/445 (20130101) A61K 31/496 (20130101) A61K 31/554 (20130101) A61K 31/5513 (20130101) A61K 49/1863 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4816 (20130101) G01R 33/5601 (20130101) G01R 33/56366 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/60 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/50 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298769 | Pak et al. |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Nikita Pak (Allston, Massachusetts); Justin P. Kinney (Quincy, Massachusetts); Edward S. Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatice control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/088494 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1695 (20130101) Original (OR) Class A61B 34/30 (20160201) A61B 34/32 (20160201) A61B 90/10 (20160201) A61B 2017/00026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298936 | Peisner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Myomo, Inc. (Cambridge, Massachusetts) |
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| INVENTOR(S) | Jeffrey Peisner (Durham, North Carolina); Andrew Harlan (Somerville, Massachusetts); Samuel Kesner (Arlington, Massachusetts); Gene Tacy (Windham, New Hampshire); Christopher Long (Willoughby, Ohio); Justin LaRue (Somerville, Massachusetts) |
| ABSTRACT | A compact, powered, orthotic device for pediatric use enables the user to control relative motion of the upper arm and the forearm about the elbow and grasping motions of the thumb and fingers. The device is powered by a set of battery-driven, backdrivable linear actuators that are positioned remotely from an arm of the subject. Control of motion of the device by the subject occurs by means of electromyographic signals from a sensor array in contact with skin on the arm of the subject. The sensors in the sensor array may be held in place on the forearm, on the upper arm, or at any other convenient location on the arm. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157154 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/013 (20130101) Original (OR) Class A61F 2005/0144 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298945 | Juhasz et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Tibor Juhasz (Oakland, California); James Jester (Oakland, California); Eric Mikula (Oakland, California) |
| ABSTRACT | A glaucoma treatment apparatus including an imaging device capable of imaging the anterior segment of the eye, a treatment laser, an algorithm programmed to determine a location and a cross sectional area of a treatment based on a customized anatomy of the anterior segment of the eye including the trabecular meshwork (TM), the Schlemm's Canal (SC) and collector channels (CCS), obtained from pre-operative images of the anterior segment of the eye, a pre-operative intraocular pressure (IOP) level and a target IOP reduction as an inputs, and a processor configured to actuate the apparatus to create an outflow channel with a cross-sectional area and location or multiple outflow channels with multiple cross-sectional areas and locations from the anterior chamber (AC) to the SC across the TM, as determined by the algorithm to achieve the target intraocular pressure (IOP) reduction. Also disclosed is a method of reducing intraocular pressure in an eye. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260367 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2017/0019 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/008 (20130101) Original (OR) Class A61F 2009/00868 (20130101) A61F 2009/00878 (20130101) A61F 2009/00891 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298984 | Bulea et al. |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept of Health and Human Services (Bethesda, Maryland) |
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| INVENTOR(S) | Thomas Bulea (Silver Spring, Maryland); Zachary Lerner (Bethesda, Maryland); Diane Damiano (Bethesda, Maryland); Andrew Gravunder (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed are powered gait assistance systems that include a controller, sensors, and a motor coupled to a patient's thigh and lower leg and operable to apply assistive torque to the patient's knee joint to assist the patient's volitional knee pivoting muscle output during selected stages of the patient's gait cycle, such that the assistive torque applied by the motor improves the patient's leg posture, muscle output, range of motion, and/or other parameters over the gait cycle. The sensors can include a torque sensor that measures torque applied by the motor, a knee angle sensor, a foot sensor that measures ground contact of the patient's foot, and/or other sensors. The controller can determine what stage of the patient's gait cycle the patient's leg is in based on sensor signals and cause the motor to apply corresponding assistive torque to the knee based on the gait cycle stage, sensor inputs, and known patient characteristics. |
| FILED | Monday, July 31, 2017 |
| APPL NO | 16/321565 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/024 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/1642 (20130101) A61H 2201/5012 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2201/5097 (20130101) A61H 2230/605 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/212 (20140902) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299060 | Farokhzad et al. |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
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| INVENTOR(S) | Omid Farokhzad (Waban, Massachusetts); Xiaoding Xu (Malden, Massachusetts); Jinjun Shi (Newton, Massachusetts) |
| ABSTRACT | Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 16/923938 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Original (OR) Class A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) A61K 47/62 (20170801) A61K 47/6935 (20170801) A61K 48/0041 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2310/351 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) Enzymes C12Y 301/03048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299078 | Naqvi et al. |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
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| INVENTOR(S) | Nawazish Naqvi (Lilburn, Georgia); Ahsan Husain (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of treating or preventing heart malformations or cardiovascular diseases comprising administering an effective amount of thyroid hormone in combination with i) an agent that decreases DUSPS and/or DUSP6 expression and/or ii) a beta-adrenergic blocking agent to a subject in need thereof. In certain embodiments, this disclosure relates to in vivo and in vitro methods of inducing proliferation of cardiomyocytes using agents or combinations of agents disclosed herein. |
| FILED | Wednesday, August 14, 2019 |
| APPL NO | 17/268590 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/403 (20130101) A61K 31/713 (20130101) A61K 38/30 (20130101) A61K 38/179 (20130101) A61K 38/1883 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299094 | LIN et al. |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
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| INVENTOR(S) | Hening LIN (Ithaca, New York); Lu ZHANG (Ithaca, New York) |
| ABSTRACT | The present disclosure is directed to a method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a TiPARP agonist, wherein the TiPARP agonist may be, for example, a tamoxifen compound (e.g., tamoxifen or derivative thereof), flavone or derivative thereof, isoflavone or derivative thereof, diindolylmethane compound, or chlorinated dibenzo-p-dioxin (CDBD) compound or derivative thereof. The cancer may be associated with elevated expression of HIF-1α and may be selected from, for example, breast cancer, colon cancer, lung cancer, skin cancer, brain cancer, blood cancer, cervical cancer, liver cancer, prostate carcinoma, pancreas carcinoma, gastric carcinoma, ovarian carcinoma, renal cell carcinoma, mesothelioma, and melanoma. The cancer may, in some embodiments, exclude breast cancer. |
| FILED | Wednesday, July 24, 2019 |
| APPL NO | 17/260124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/138 (20130101) A61K 31/352 (20130101) A61K 31/357 (20130101) A61K 31/404 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299095 | Dealwis |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | Chris Dealwis (Highland Heights, Ohio) |
| ABSTRACT | A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a hydrazone or hydrazine ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth. |
| FILED | Thursday, July 18, 2019 |
| APPL NO | 17/260998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/52 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 31/426 (20130101) A61K 31/4406 (20130101) A61K 31/4412 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299105 | PATEL et al. |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
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| INVENTOR(S) | Preeyam S. PATEL (New York, New York); Robert J. SCHNEIDER (New York, New York) |
| ABSTRACT | Disclosed herein is a method of inhibiting T Follicular Helper (TFH) cell-mediated differentiation and/or activation in a subject. This method involves administering to a subject in need of treatment for an autoimmune disorder a eukaryotic translation initiation factor 4E (eIF4E) inhibitor to inhibit TFH cell-mediated differentiation and/or activation in the subject. Also disclosed is a method of inhibiting T Follicular Helper (THF) cell differentiation or TFH cell activity. |
| FILED | Wednesday, December 02, 2020 |
| APPL NO | 17/110023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299107 | Stockwell et al. |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. Stockwell (New York, New York); Arie Zask (New York, New York); Hui Tan (New York, New York); Jacob Daniels (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/330386 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/166 (20130101) A61K 31/245 (20130101) A61K 31/421 (20130101) A61K 31/4245 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) A61P 39/06 (20180101) Acyclic or Carbocyclic Compounds C07C 229/60 (20130101) C07C 233/65 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 213/80 (20130101) C07D 263/32 (20130101) C07D 271/10 (20130101) C07D 295/13 (20130101) C07D 413/04 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299114 | Nagaraj et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ram H. Nagaraj (Aurora, Colorado); Rooban B. Nahomi (Aurora, Colorado); Mi-hyun Nam (Aurora, Colorado) |
| ABSTRACT | Methods of treating, reducing the risk of, preventing, or alleviating at least one symptom of a retinal disease, injury, or condition in a subject involve administering a pharmaceutically effective amount of kynurenic acid to the subject. The kynurenic acid may be administered intravenously or intravitreally. Systems for treating retinal diseases, injuries, or conditions are also disclosed and may include an administration device. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/199896 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 27/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299118 | Smallwood et al. |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather Smallwood (Memphis, Tennessee); Marie Morfouace (Cambridge, United Kingdom); Martine F. Roussel (Memphis, Tennessee); Paul G. Thomas (Memphis, Tennessee) |
| ABSTRACT | The invention generally relates to methods of treating viral infections using known drugs and pharmaceutical compositions comprising same. More specifically, the disclosed methods are useful for the treatment of viral infections that are enveloped viruses. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315136 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/34 (20130101) A61K 31/277 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/415 (20130101) A61K 31/416 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/454 (20130101) A61K 31/505 (20130101) A61K 31/519 (20130101) A61K 31/555 (20130101) A61K 31/4164 (20130101) A61K 31/4174 (20130101) A61K 31/4439 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 31/7004 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299123 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ting Zhang (Carmel, Indiana); Jing-Yuan Liu (Indianapolis, Indiana); Mingji Dai (West Lafayette, Indiana) |
| ABSTRACT | Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299130 | Strum et al. |
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| FUNDED BY |
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| APPLICANT(S) | G1 Therapeutics, Inc. (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | G1 Therapeutics, Inc. (Research Triangle Park, North Carolina) |
| INVENTOR(S) | Jay Copeland Strum (Hillsborough, North Carolina); John Emerson Bisi (Chapel Hill, North Carolina); Patrick Joseph Roberts (Durham, North Carolina); Francis Xavier Tavares (Durham, North Carolina) |
| ABSTRACT | This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, improved protection of healthy cells is disclosed using disclosed compounds that act as highly selective and short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222873 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/519 (20130101) A61K 31/527 (20130101) Original (OR) Class A61K 31/555 (20130101) A61K 31/5377 (20130101) A61K 31/7048 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Heterocyclic Compounds C07D 487/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299131 | Grimaldi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maurizio Grimaldi (Birmingham, Alabama); Judith Varady Hobrath (Pinson, Alabama); Subramaniam Ananthan (Birmingham, Alabama); Joseph A. Maddry (Birmingham, Alabama) |
| ABSTRACT | Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193945 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/136 (20130101) A61K 31/426 (20130101) A61K 31/427 (20130101) A61K 31/444 (20130101) A61K 31/675 (20130101) A61K 31/5377 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299138 | Edge et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Edge (Brookline, Massachusetts); Hideyuki Okano (Tokyo, Japan); Masato Fujioka (Tokyo, Japan); Kunio Mizutari (Tokyo, Japan) |
| ABSTRACT | This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults. |
| FILED | Thursday, December 10, 2020 |
| APPL NO | 17/118111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/55 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299144 | Kleene et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio); Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio); Children's Hospital Medical Center (Cincinnati, Ohio) |
| INVENTOR(S) | Steven J Kleene (Cincinnati, Ohio); Nancy K Kleene (Cincinnati, Ohio); Bradley P Dixon (Centennial, Colorado); Brian J Siroky (Edgewood, Kentucky) |
| ABSTRACT | A method for the treatment or the prevention of a kidney disorder is disclosed. The method involves administering an effective concentration of pregnenolone sulfate to a subject to increase cytoplasmic Ca2+ in kidney cells. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 17/265096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/57 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299158 | Ameer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Guillermo A. Ameer (Chicago, Illinois); Jason A. Wertheim (Chicago, Illinois); Bin Jiang (Evanston, Illinois) |
| ABSTRACT | Disclosed are heparin conjugates comprising heparin conjugated to a peptide that binds to a protein of the extracellular matrix (ECM) of cellular tissue, such as a collagen-binding peptide that binds to collagen of the ECM. The disclosed heparin conjugates may be utilized in methods that include treating ECM material to incorporate the heparin conjugates and impart anticoagulant activity to the ECM. The disclosed heparin conjugates also may be formulated as pharmaceutical compositions for treating and/or preventing vascular injuries and conditions. |
| FILED | Thursday, October 11, 2018 |
| APPL NO | 16/755494 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 47/547 (20170801) A61K 47/6425 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299186 | Wucherpfennig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai W. Wucherpfennig (Brookline, Massachusetts); Soumya Badrinath (Boston, Massachusetts) |
| ABSTRACT | The present invention provides compositions and methods for treating cancer in a subject by eliciting an immune response against a MIC alpha 3-domain polypeptide. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180183 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/105 (20130101) A61K 2039/645 (20130101) A61K 2039/6068 (20130101) A61K 2039/55522 (20130101) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Peptides C07K 16/121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299212 | PANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongbo PANG (Vadnais Heights, Minnesota) |
| ABSTRACT | Provided herein are binding molecules to tumor associated macrophages and associated methods for the treatment and detection of cancer. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 17/267175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 49/0043 (20130101) A61K 49/0056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2857 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/5055 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299224 | OH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | SangKon OH (Baltimore, Maryland); Sandra ZURAWSKI (Midlothian, Texas); Hyemee JOO (Dallas, Texas); Gerard ZURAWSKI (Midlothian, Texas) |
| ABSTRACT | Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/301123 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/2066 (20130101) Original (OR) Class A61K 39/0008 (20130101) A61K 2039/54 (20130101) A61K 2039/57 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/5428 (20130101) C07K 16/2851 (20130101) C07K 16/2878 (20130101) C07K 2317/24 (20130101) C07K 2317/40 (20130101) C07K 2317/52 (20130101) C07K 2317/53 (20130101) C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/75 (20130101) C07K 2317/565 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299233 | GUTIERREZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Alejandro GUTIERREZ (Boston, Massachusetts); Laura HINZE (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject having cancer an asparaginase and an agent that inhibits GSK3f. Another aspect of the invention relates to administering an asparaginase to a subject having cancer that comprises an inactivating mutation in GSK3f. |
| FILED | Wednesday, June 12, 2019 |
| APPL NO | 17/258693 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/407 (20130101) A61K 31/426 (20130101) A61K 31/433 (20130101) A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/4375 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 31/5517 (20130101) A61K 38/50 (20130101) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299237 | CHAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | ADJUVANCE TECHNOLOGIES, INC. (New York, New York) |
| ASSIGNEE(S) | ADJUVANCE TECHNOLOGIES, INC. (New York, New York) |
| INVENTOR(S) | Amanda CHAN (Hopewell Junction, New York); Jeffrey GARDNER (New York, New York); Lars NORDSTROEM (New York, New York); William WALKOWICZ (Brooklyn, New York); J Tyler MARTIN (Roca, Nebraska); Weidong Zhang (Albany, New York) |
| ABSTRACT | The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases. |
| FILED | Friday, April 13, 2018 |
| APPL NO | 16/604867 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/05 (20130101) A61K 39/08 (20130101) A61K 39/0018 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/092 (20130101) A61K 39/099 (20130101) A61K 39/292 (20130101) A61K 2039/6037 (20130101) A61K 2039/55577 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/20 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/08 (20130101) C07H 15/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299238 | Garcea et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); JOHNS HOPKINS UNIVERSITY (Baltimroe, Maryland); MEDICAL UNIVERSITY OF VIENNA (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert L. Garcea (Boulder, Colorado); Theodore Randolph (Niwot, Colorado); Richard Roden (Severna Park, Maryland); Reinhard Kirnbauer (Sooss, Austria) |
| ABSTRACT | Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable broad spectrum human papilloma virus (HPV) vaccine or immunogenic formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines and other immunogenic agents to increase stability or reduce degradation of HPV peptides to prolong storage, delivery and use. In yet other embodiments, a single immunogenic formulation can include a thermally stable composition of a broad-spectrum HPV immunogenic composition against multiple HPV types. In some embodiments, a stabilizing formulation can include RG1 HPV16VLP antigens in a hypertonic mixture of a disaccharide and a volatile buffer. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55505 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299242 | Graham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Barney Graham (Rockville, Maryland); Rebecca Loomis (Bethesda, Maryland); Guillaume Stewart-Jones (Cambridge, Massachusetts); John Mascola (Rockville, Maryland); Jason McLellan (Austin, Texas) |
| ABSTRACT | Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject. |
| FILED | Monday, August 05, 2019 |
| APPL NO | 17/261828 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Original (OR) Class A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18222 (20130101) C12N 2760/18223 (20130101) C12N 2760/18234 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299243 | Hartigan-O'Connor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Dennis Hartigan-O'Connor (Davis, California) |
| ABSTRACT | Provided herein are methods for inducing an immune response against an antigen in a subject. In some embodiments, the methods comprise administering a therapeutically effective amount of a vaccine and an interleukin 10 (IL-10) inhibitor to the subject. In some embodiments, the vaccine is an IL-10-deficient vaccine. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/173118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 38/1793 (20130101) A61K 38/2066 (20130101) A61K 39/0011 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/55 (20130101) A61K 2039/505 (20130101) A61K 2039/5256 (20130101) Peptides C07K 16/244 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/10034 (20130101) C12N 2710/16134 (20130101) C12N 2740/15034 (20130101) C12N 2740/16034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299250 | Levy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Ofer Levy (Cambridge, Massachusetts); David J. Dowling (Brighton, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); Carlo Pietrasanta (Boston, Massachusetts) |
| ABSTRACT | Provided herein are Stimulator of Interferon Genes (STING) ligand for use in enhancing immune response and/or as adjuvants in vaccines. In some embodiments, STING ligand is used alone or in combination with Alum in an adjuventation system for early life immunization. |
| FILED | Tuesday, November 27, 2018 |
| APPL NO | 16/766902 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299272 | Muzykantov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Muzykantov (Bryn Athyn, Pennsylvania); Jacob S. Brenner (Princeton Junction, New Jersey); Carlos H. Villa (Philadelphia, Pennsylvania); Laura Ferguson (Philadelphia, Pennsylvania); Elizabeth Hood (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions comprising a dual-targeted nanoparticle having a first targeting moiety and a second targeting moiety, wherein said first targeting moiety is a red blood cell (RBC)-targeting moiety are provided. In certain embodiment, the nanoparticles are bound to RBCs ex vivo. Also provided are methods of delivering selected drugs to target organs using these compositions for treatment of disease or for diagnostic imaging. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219295 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/6929 (20170801) Original (OR) Class Peptides C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299277 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric A. Pierce (Belmont, Massachusetts); Luk H. Vandenberghe (Weston, Massachusetts); Scott Greenwald (Boston, Massachusetts); Emily Brown (Boston, Massachusetts) |
| ABSTRACT | Methods and compositions for gene therapy of retinal degeneration related to mutations in nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1). |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199115 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/45 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Enzymes C12Y 207/07001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299352 | El-Khatib et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BETA BIONICS, INC. (Concord, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Firas H. El-Khatib (Allston, Massachusetts); Edward R. Damiano (Acton, Massachusetts) |
| ABSTRACT | A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213929 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 5/14244 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/16 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/3553 (20130101) A61M 2205/3561 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 20/17 (20180101) G16H 20/60 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300754 | OSTROVSKA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lyubov OSTROVSKA (Reisterstown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyubov OSTROVSKA (Reisterstown, Maryland) |
| ABSTRACT | The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. Due to the fact that circulating stem cells home to tumors and metastasis, and participate in neovascularization of growing tumors, the NLSC of the present invention allows tracking of the tissue distribution of infused stem cells and selective heating of targeted tissues with AMF. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions. The heating of diseased tissue either results in direct cell killing or makes the tumor more susceptible to radio- and/or chemotherapy. The targeted hyperthermia provided by the present invention has clinical potential because it is associated with fewer side effects, and can also be used in combination with conventional treatment modalities, significantly enhancing their effectiveness. The NLSC of the present invention can be used for MR image-guided hyperthermia in oncology, in stem cell research for cell tracking and heating, and for elimination of mis-injected stem cells. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231221 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0052 (20130101) A61K 49/1863 (20130101) A61K 49/1896 (20130101) A61K 2035/124 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 2529/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300872 | Blagg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian S.J. Blagg (Niles, Michigan); Vincent Matthew Crowley (Lawrence, Kansas) |
| ABSTRACT | The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/341047 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/78 (20130101) C07C 219/34 (20130101) Heterocyclic Compounds C07D 213/643 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300882 | Kelly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (La Jolla, California) |
| INVENTOR(S) | Daniel Kelly (Philadelphia, Pennsylvania); Richard Vega (Orlando, Florida); Hampton Sessions (Orlando, Florida); Teresa Leone (Philadelphia, Pennsylvania); Byungyong Ahn (Wallingford, Pennsylvania); Satyamaheshwar Peddibhotla (Orlando, Florida) |
| ABSTRACT | Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject. Also disclosed are method for treating one or more Myc-driven cancers, including neuroblastoma, lung squamous cell carcinoma/lung adenocarcinoma, liver hepatocellular carcinoma, colon adenocarcinoma, acute myeloid leukemia, and breast invasive carcinoma. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342187 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/428 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/541 (20130101) A61K 31/4439 (20130101) A61K 31/5375 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) Heterocyclic Compounds C07D 277/46 (20130101) Original (OR) Class C07D 277/82 (20130101) C07D 295/185 (20130101) C07D 417/04 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300911 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186651 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/444 (20130101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 403/06 (20130101) C07D 417/04 (20130101) C07D 417/06 (20130101) Original (OR) Class C07D 471/04 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300937 | Makriyannis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alexandros Makriyannis (Watertown, Massachusetts); Spyridon P. Nikas (Newton, Massachusetts); Christos Iliopoulos Tsoutsouvas (Allston, Massachusetts); Shashank Kulkarni (Billerica, Massachusetts); Lipin Ji (Malden, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandros Makriyannis (Watertown, Massachusetts); Spyridon P. Nikas (Newton, Massachusetts); Christos Iliopoulos Tsoutsouvas (Allston, Massachusetts); Shashank Kulkarni (Billerica, Massachusetts); Lipin Ji (Malden, Massachusetts) |
| ABSTRACT | Novel cannabinoid ligands represented by the general formulas I, II, and III and methods for preparation and use within which one or more of a fluorescent ligand, nitroxide spin label, metal chelate, biotin moiety, or group with enhanced polarity may be incorporated. The compounds can bind to and modulate the cannabinoid CB1 and CB2 receptors and thereby considered specific ligands for these receptors. Some of the disclosed compounds that bind to cannabinoid CB1 and CB2 receptors can exhibit tight or irreversible binding characteristics for these receptors. Due to the presence of the imaging/diagnostic and/or therapeutic functional groups including fluorescent groups, nitroxide spin labels, metal chelates, biotin moieties, and groups with enhanced polarity, the disclosed compounds may be useful as imaging/diagnostic tools and/or therapeutic agents. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205300 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/78 (20130101) C07D 405/06 (20130101) C07D 405/14 (20130101) C07D 407/12 (20130101) C07D 413/14 (20130101) C07D 491/16 (20130101) Original (OR) Class C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300941 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Eric Fischer (Chestnut Hill, Massachusetts); Alyssa Verano (Allston, Massachusetts); Zhixiang He (Brookline, Massachusetts); Guangyan Du (Jamaica Plain, Massachusetts); Katherine Donovan (Boston, Massachusetts); Radoslaw Nowak (Boston, Massachusetts); Jing Ting Christine Yuan (Brookline, Massachusetts) |
| ABSTRACT | Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/255772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 495/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300973 | LIGHTFOOT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YAIMA L. LIGHTFOOT (WASHINGTON, District of Columbia); BIKASH SAHAY (GAINESVILLE, Florida); MANSOUR MOHAMADZADEH (GAINESVILLE, Florida) |
| ABSTRACT | The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant L. acidophilus cells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinant L. acidophilus cells or SlpA isolated from L. acidophilus can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/747 (20130101) A61K 38/13 (20130101) A61K 38/164 (20130101) Peptides C07K 14/335 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/746 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300978 | Ildefonso et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Cristhian J. Ildefonso (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Qiuhong Li (Gainesville, Florida) |
| ABSTRACT | The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/1709 (20130101) A61K 48/0075 (20130101) Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/10 (20130101) C07K 2319/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300981 | Hughes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, None) |
| INVENTOR(S) | Molly A. Hughes (Charlottesville, None); Matthew Crawford (Charlottesville, Virginia); Rachel Letteri (Charlottesville, None) |
| ABSTRACT | Provided are peptides, modified peptides, fragments thereof, conjugates thereof, and polymers thereof that have antibacterial activity against bacterial that include but are not limited to multidrug-resistant bacteria. In some embodiments, the presently disclosed subject matter relates to peptides that include the amino acid sequences RTVRCTCI (SEQ ID NO: 2), LSRTVRCTCISI (SEQ ID NO: 3) or VPLSRTVRCTCISI (SEQ ID NO: 4), PESK AIKNLLK AV SKERSKRSP (SEQ ID NO: 11), or KNLLK AV SKERSKRSP (SEQ ID NO: 12), modified peptides thereof, fragments thereof, and conjugates thereof, and any combination thereof. The peptides, modified peptides, fragments thereof, and conjugates thereof can be polymer-functionalized, encapsulated in a particle, embedded in and/or on a solid support, optionally wherein the peptide is formulated for release from the solid support, impregnated in a dressing, optionally wherein the peptide is formulated for release from the dressing, and/or is formulated for use in a nebulizer, for topical administration, and/or for systemic administration. Also provided are medical devices having a support layer with an antibacterial agent embedded therein or associated therewith, methods for inhibiting the growth of and/or killing bacteria, for recruiting immune cells to site of infection, for treating or preventing community and/or nosocomial infections, for inducing a subjects immune system against a pathogen, for treating bacterial infections present in wounds, for treating pulmonary infections, for treating or preventing systemic bacterial infections, and for combination therapies with conventional antibiotics. |
| FILED | Wednesday, July 24, 2019 |
| APPL NO | 17/262667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/522 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300982 | Murphy Topp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth M. Murphy Topp (Lafayette, Indiana); Hamed Tabatabaei Ghomi (San Diego, California); Markus Lill (West Lafayette, Indiana); Shenbaga Moorthy Balakrishnan (Virudhunagar District, India) |
| ABSTRACT | The invention generally relates to modified glucagon molecules. In certain embodiments, the invention provides a glucagon molecule that includes one or more modified amino acids to result in the glucagon molecule being soluble at a substantially neutral pH and resistant to fibrillation. Modifications may include, for example, phosphorylation or sulfation. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177799 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/26 (20130101) A61K 47/52 (20170801) Peptides C07K 14/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300988 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Rockville, Maryland); Anna Pasetto (Stockholm, Sweden); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Zhili Zheng (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345390 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300989 | JENKINS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Marc Kevin JENKINS (Minneapolis, Minnesota); Thamotharampillai DILEEPAN (Minneapolis, Minnesota); Deepali MALHOTRA (Minneapolis, Minnesota) |
| ABSTRACT | The present disclosure provides variant major histocompatibility complex class II (MHCII) beta chains, as well as heterodimers and multimers including MHCII alpha chains and the variant MHCII beta chains. Also provided by the present disclosure are nucleic acids, expression cassettes, and expression vectors encoding the MHCII beta chains. The heterodimers and multimers of the present disclosure have a higher affinity for CD4 co-receptors than comparable reagents including wild type MHCII beta chains, and therefore are advantageous for use in methods of phenotyping or activating CD4+ T cells. |
| FILED | Thursday, August 01, 2019 |
| APPL NO | 17/264707 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) Original (OR) Class C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/582 (20130101) G01N 33/54366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300998 | SHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | Yanhong SHI (Arcadia, California); Guoqiang SUN (Diamond Bar, California); Xianwei CHEN (Arcadia, California) |
| ABSTRACT | Disclosed are methods of producing human iPSC-derived brain organoids and uses thereof to detect and develop treatment for HCMV-induced brain deformation in developing fetus. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208300 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Peptides C07K 16/088 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300999 | CROWE, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | James E. CROWE, JR. (Nashville, Tennessee); Seth ZOST (Nashville, Tennessee); Robert CARNAHAN (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301002 | Bennett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biogen MA Inc. (Cambridge, Massachusetts); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | Biogen MA Inc. (Cambridge, Massachusetts); The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Jeffrey L. Bennett (Denver, Colorado); Richard M. Ransohoff (Boston, Massachusetts); Fumitaka Shimizu (Yamaguchi, Japan); Kristin L. Schaller (Denver, Colorado) |
| ABSTRACT | This disclosure provides anti-HSPA5 antibodies. Also featured is a method for delivering an agent into the brain, spinal cord, or other component of the central nervous system. In addition, methods of identifying a human subject at risk of relapse of neuromyelitis optica (NMO) or neuropsychiatric systemic lupus erythematosus (NP-SLE) are disclosed, as are methods of determining the severity of an attack of NMO or NP-SLE, and methods of diagnosing NP-SLE. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182426 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 45/06 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301254 | Karp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Michael Karp (Chestnut Hill, Massachusetts); Xiaolei Yin (Quincy, Massachusetts); Marc David Succi (Boston, Massachusetts); Robert Samuel Langer (Newton, Massachusetts) |
| ABSTRACT | Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/506 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/068 (20130101) Original (OR) Class C12N 5/0679 (20130101) C12N 2501/11 (20130101) C12N 2501/42 (20130101) C12N 2501/065 (20130101) C12N 2501/73 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301261 | TAYLOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | D. Lansing TAYLOR (Pittsburgh, Pennsylvania); Albert GOUGH (Glenshaw, Pennsylvania); Larry VERNETTI (Wexford, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | D. Lansing TAYLOR (Pittsburgh, Pennsylvania); Albert GOUGH (Glenshaw, Pennsylvania); Larry VERNETTI (Wexford, Pennsylvania) |
| ABSTRACT | Microfluidic devices for modeling three-dimensional tissue structures and methods for making and using the same are described herein. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343411 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 2300/0636 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2502/11 (20130101) C12N 2502/14 (20130101) C12N 2502/28 (20130101) C12N 2510/00 (20130101) C12N 2513/00 (20130101) C12N 2533/50 (20130101) C12N 2533/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5067 (20130101) G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301263 | MCFADDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Grant MCFADDEN (Tempe, Arizona); Mohammed Masmudur RAHMAN (Chandler, Arizona) |
| ABSTRACT | A method of producing poxviruses at an increased growth rate and/or progeny virus titer in cells, the method including: contacting a host cell with an effective amount of nucleocytoplasmic transport inhibitor; contacting the host cell with a poxvirus of interest under conditions that permit the poxvirus of interest to adsorb to the surface of the host cell; and culturing the host cell to produce progeny poxvirus of interest. |
| FILED | Wednesday, August 07, 2019 |
| APPL NO | 17/266499 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2710/24051 (20130101) C12N 2710/24151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301269 | Sanjana et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Zharko Daniloski (New York, New York); Mateusz Legut (Jersey City, New Jersey) |
| ABSTRACT | Provided herein is a recombinant or engineered Cas9 protein. The Cas9 protein has an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO: 2. The Cas9 protein has at least one mutation in an amino acid residue selected from 262, 324, 409, 480, 543, 694, of the amino acid sequence provided in SEQ ID NO: 2 or the corresponding residue of an aligned sequence, and at least one mutation in an amino acid residue selected from 1111, 1135, 1218, 1219, 1322, 1335, and 1337, of the amino acid sequence provided in SEQ ID NO: 2 or the corresponding residue of an aligned sequence. The amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154826 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/1082 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301272 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Xu (Troy, Michigan); Jifeng Zhang (Ann Arbor, Michigan); Yuqing Eugene Chen (Superior Township, Michigan); Dongshan Yang (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to molecular biological manipulation of genes and genomes and particularly, but not exclusively, to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) methods, compositions, systems, and kits for improved genetic editing. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/258776 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2207/05 (20130101) A01K 2217/072 (20130101) Peptides C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301278 | Kohli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Rahul Kohli (Penn Valley, Pennsylvania); Emily Schutsky (Philadelphia, Pennsylvania); Monica Yun Liu (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes mutant AID, APOBEC, and Tet enzymes with improved functions. In one aspect the invention provides APOBEC fusion proteins comprising hyperactive deamination activity. In another aspect, the invention provides AID mutant proteins comprising hyperactive deamination activity. In yet another aspect, the invention provides mutant Tet proteins capable of stalling oxidation at a 5-hydroxymethylcytosine (hmC). |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207101 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) C12N 9/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301286 | Bradner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | James Bradner (Weston, Massachusetts); Justin Roberts (Cambridge, Massachusetts); Behnam Nabet (Boston, Massachusetts); Georg Winter (Vienna, Austria); Andrew J. Phillips (Arlington, Massachusetts); Timothy Heffernan (Sugar Land, Texas); Dennis Buckley (Jamaica Plain, Massachusetts) |
| ABSTRACT | This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 31/575 (20130101) A61K 31/4525 (20130101) A61K 31/4545 (20130101) A61K 31/4985 (20130101) A61K 31/5513 (20130101) A61K 35/17 (20130101) A61K 2035/122 (20130101) Peptides C07K 14/47 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/00 (20130101) C07K 16/2863 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/20 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301287 | Arany et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zoltan Arany (Merion Station, Pennsylvania); Bridget Gosis (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided herein are compositions for preventing or treating nonalcoholic fatty liver disease or nonalcoholic steatohepatitis in a subject comprising an inhibitor of folliculin, methods for preventing or treating nonalcoholic fatty liver disease or nonalcoholic steatohepatitis in a subject comprising administering to the liver of the subject an inhibitor of folliculin, and methods for preventing or treating nonalcoholic fatty liver disease or nonalcoholic steatohepatitis in a subject comprising silencing or down-regulating FLCN in hepatocytes of the subject. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/156348 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1135 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/3535 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301298 | BOURDEAU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond W. BOURDEAU (Watertown, Massachusetts); Anupama LAKSHMANAN (Pasadena, California); Arash FARHADI (Pasadena, California); Mikhail G. SHAPIRO (Los Angeles, California); Audrey LEE-GOSSELIN (Pasadena, California) |
| ABSTRACT | Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site. |
| FILED | Monday, May 31, 2021 |
| APPL NO | 17/334953 |
| CURRENT CPC | Peptides C07K 14/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/75 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301316 | LEWIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim LEWIS (Newton, Massachusetts); Anthony D'ONOFRIO (Northborough, Massachusetts); Thomas CURTIS (Boston, Massachusetts); Charlotte BERKES (Melrose, Massachusetts) |
| ABSTRACT | Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated. |
| FILED | Friday, May 24, 2019 |
| APPL NO | 17/262031 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301321 | Ellington et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Yu Sherry Jiang (Austin, Texas); Sanchita Bhadra (Austin, Texas); Bingling Li (Austin, Texas); Randy Allen Hughes (Austin, Texas); Yan Du (Austin, Texas); Jimmy Gollihar (Hewitt, Texas) |
| ABSTRACT | Disclosed are methods for isothermal nucleic acid amplification and detection. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209600 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301326 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Nathan G. SCHOEPP (Burlingame, California); Emily S. SAVELA (Pasadena, California); Eric J. LIAW (Pasadena, California); Alexander WINNETT (Pasadena, California); Matthew M. COOPER (Pasadena, California) |
| ABSTRACT | Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/164674 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301346 | Johnson |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bankole A. Johnson (Charlottesville, Virginia) |
| ABSTRACT | The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/301660 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/942 (20130101) G01N 33/6872 (20130101) G01N 2800/50 (20130101) G01N 2800/307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301349 | PANDOLFI |
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| FUNDED BY |
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| APPLICANT(S) | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (BOSTON, Massachusetts) |
| INVENTOR(S) | PIER PAOLO PANDOLFI (BOSTON, Massachusetts) |
| ABSTRACT | As described below, the present invention features compositions and methods of treating cancers characterized by the loss of Pten, Zbtb7a/Pokemon, p53, Pml and other tumor suppressors by inhibiting the expression or activity of CXCL5; and methods for identifying therapeutics using a murine platform. |
| FILED | Tuesday, August 29, 2017 |
| APPL NO | 16/328623 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) A01K 2207/12 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Peptides C07K 16/24 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301352 | Velculescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of Torino (Torino, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor E. Velculescu (Dayton, Maryland); Eniko Papp (Baltimore, Maryland); Vilmos Adleff (Baltimore, Maryland); Andrea Bertotti (Torino, Italy); Livio Trusolino (Torino, Italy) |
| ABSTRACT | Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade. Amplifications and sequence changes in the tyrosine kinase receptor adaptor gene IRS2 were identified in tumors with increased sensitivity to anti-EGFR therapy. Therapeutic resistance to EGFR blockade could be overcome in tumorgraft models through combinatorial therapies targeting actionable genes. These analyses provide a systematic approach to evaluate response to targeted therapies in human cancer, highlight additional mechanisms of responsiveness to anti-EGFR therapies, and provide additional avenues for intervention in the management of colorectal cancer. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301356 | de Vlaminck et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iwijn de Vlaminck (Stanford, California); Michael Kertesz (Menlo Park, California); Kiran Kaur Khush (Stanford, California); Mark Alec Kowarsky (Kowarsky, Australia); Lance Martin (Half Moon Bay, California); Stephen R. Quake (Stanford, California); Hannah Valantine (Stanford, California) |
| ABSTRACT | Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347247 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/705 (20130101) Original (OR) Class C12Q 1/6883 (20130101) C12Q 1/6895 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302287 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siyang Zheng (State College, Pennsylvania); Mauricio Terrones (State College, Pennsylvania); Yin-Ting Yeh (State College, Pennsylvania); Yi Tang (State College, Pennsylvania); Huaguang Lu (State College, Pennsylvania); Nestor Perea Lopez (State College, Pennsylvania); Yiqiu Xia (State College, Pennsylvania) |
| ABSTRACT | The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236814 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class G01N 1/4077 (20130101) G01N 33/552 (20130101) G01N 33/54346 (20130101) G01N 33/56983 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302334 | ROS et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra ROS (Phoenix, Arizona); Daihyun KIM (Mesa, Arizona); Austin ECHELMEIER (Tempe, Arizona); Jorvani CRUZ VILLARREAL (Tempe, Arizona); Ana EGATZ-GOMEZ (Phoenix, Arizona); Sebastian QUINTANA (Phoenix, Arizona) |
| ABSTRACT | Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220357 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0241 (20130101) B01L 3/50273 (20130101) B01L 2300/0867 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20025 (20130101) Original (OR) Class G01N 2223/602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302410 | WADUGE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradeep WADUGE (East Boston, Massachusetts); Joseph LARKIN (Dorchester, Massachusetts); Moneesh UPMANYU (Belmont, Massachusetts); Swastik KAR (Belmont, Massachusetts); Meni WANUNU (Needham, Massachusetts) |
| ABSTRACT | Described herein are devices containing freestanding, ultrathin (<10 nm thick) membranes and methods of making such devices. Also described are methods of using devices containing freestanding ultrathin membranes for determining the sequence of a polynucleotide and for desalination of aqueous solutions. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344035 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/186 (20170801) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/56 (20130101) C23C 16/0281 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4473 (20130101) G01N 27/44704 (20130101) G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302413 | Fu et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dax Fu (Short Hills, New Jersey); Chengfeng Merriman (Essex, Maryland) |
| ABSTRACT | The present invention relates to the fields of immunology and diabetes. More specifically, the present invention provides methods and compositions directed to the use of antibodies to quantify cellular pancreatic zinc transporter 8. In certain embodiment, the present invention provides methods and compositions directed to the use of antibodies to screen for modulators of the pancreatic zinc transporter, ZnT8. In one embodiment, a method comprises the steps of (a) permeabilizing human beta cells present in a substrate; (b) contacting the cells with a test agent; and (c) measuring the amount of zinc transporter 8 (ZnT8) using at least one anti-ZnT8 antibody or antigen-binding fragment thereof. |
| FILED | Tuesday, December 01, 2020 |
| APPL NO | 17/108441 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) C07K 2317/55 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/507 (20130101) Original (OR) Class G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302422 | SETLIFF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marion Francis SETLIFF (Nashville, Tennessee); Ivelin Stefanov GEORGIEV (Brentwood, Tennessee); Andrea SHIAKOLAS (Nashville, Tennessee) |
| ABSTRACT | The present disclosure relates to a system for simultaneous detection of antigens and antigen specific antibodies, and methods of use thereof. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/266169 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) Original (OR) Class G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302435 | Hahn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Sihoun Hahn (Clyde Hill, Washington); Christopher Collins (Seattle, Washington); Remwilyn Dayuha (Lynnwood, Washington); Fan Yi (Shoreline, Washington) |
| ABSTRACT | Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219776 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6854 (20130101) Original (OR) Class G01N 2800/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302437 | HARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua M. HARE (Miami Beach, Florida); Bettina HEIDECKER (Miami, Florida) |
| ABSTRACT | Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/092468 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302438 | CAI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Hua CAI (LOS ANGELES, California) |
| ABSTRACT | A method for detecting thoracic aortic aneurysm (TAA) or predisposition to TAA in a subject comprises measuring the amount of tetrahydrobiopterin (H4B) present in the test sample; and comparing a measured amount of HUB to a standard amount of H4B. A decreased amount of H4B present in the test sample compared to the standard is indicative of TAA or predisposition to TAA. The method can further comprise identifying a candidate for further testing or monitoring for TAA, such as by ultrasound or by repeated testing for H4B after one or more designated intervals. The method can also further comprise prescribing treatment for TAA to the subject, such as with folic acid therapy, and/or DHFR therapy, including gene therapy, and other therapies effective for recoupling eNOS and/or therapies targeting uncoupled eNOS. Methods are also described for monitoring the efficacy of treatment of TAA, and for evaluating the severity of TAA or risk of TAA. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/329 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302439 | Ziady et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Assem Ziady (Newport, Kentucky); Rhonda Szczesniak (Burlington, Kentucky); Emrah Gecili (Cincinnati, Ohio); Zackary Cleveland (Cincinnati, Ohio) |
| ABSTRACT | Disclosed herein are methods for detecting protein expression in an individual diagnosed with cystic fibrosis. The methods, in certain aspects, include the steps of obtaining a sample from said individual and detecting expression in said sample of each protein of a protein set. The method may further include the step of determining expression level of one or more proteins of the protein set. The disclosed methods may be used to predict one or more clinical parameters in an individual having cystic fibrosis. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333058 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/914 (20130101) G01N 2800/50 (20130101) G01N 2800/56 (20130101) G01N 2800/382 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210303818 | Randolph et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body Corporate (Denver, Colorado); Ursa Analytics, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore W. Randolph (Niwot, Colorado); Austin Lewis Daniels (Littleton, Colorado); Christopher P. Calderon (Denver, Colorado) |
| ABSTRACT | The current invention describes systems, methods and apparatus for the combination of high-throughput flow imaging microscopy coupled with convolutional neural networks to analyze particles, such as aggregated biomolecules, and cells for use in in a variety of diagnostic, therapeutic and industrial applications. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/264690 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1475 (20130101) G01N 2015/1006 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) Original (OR) Class G06K 9/00147 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304848 | Buhler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Daniel Buhler (St. Louis, Missouri); Roger Dean Chamberlain (St. Louis, Missouri); Mark Allen Franklin (St. Louis, Missouri); Kwame Gyang (St. Louis, Missouri); Arpith Chacko Jacob (St. Louis, Missouri); Praveen Krishnamurthy (St. Louis, Missouri); Joseph Marion Lancaster (St. Louis, Missouri) |
| ABSTRACT | Apparatuses and methods are disclosed for comparing a first biosequence string with a second biosequence string to assess similarity between those biosequence strings. For example, a field programmable gate array (FPGA) can be used to (1) detect substrings of the second biosequence string that are matches to substrings of the first biosequence string, and (2) map the detected substrings of the second biosequence string to corresponding positions in the first biosequence string where the detected substrings are located based on a data structure that links substrings of the first biosequence string to positions in the first biosequence string where the substrings of the first biosequence string are located. These operations can be used to seed an alignment between the first and second biosequence strings that permits comparisons to be performed over longer substrings of the first and second biosequence strings so that similarities between those longer substrings can be quantified. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209464 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2255 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 50/00 (20190201) G16B 50/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304899 | Springer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Charles Springer (Portland, Oregon); Gregory Wilson (Seattle, Washington); Jeffrey Maki (Seattle, Washington); Thomas Barbara (Portland, Oregon); Xin Li (Portland, Oregon); William Rooney (Portland, Oregon); Wei Huang (Portland, Oregon); Brendan Moloney (Portland, Oregon); Eric Baker (Portland, Oregon) |
| ABSTRACT | Methods, computer-readable storage media and systems are described for constructing a three-dimensional electronic library of simulated decays of the diffusion-weighted 1H2O MR signal in b-space. Methods, computer-readable media, and systems are described for preparing a parametric tissue map for tissue in a subject. Computer readable media, having an electronic library of simulated decays of the diffusion-weighted 1H2O signal in b-space and method of using such a library. |
| FILED | Friday, April 06, 2018 |
| APPL NO | 16/497513 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/56341 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306777 | Rucker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Earlens Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Rucker (San Francisco, California); Sunil Puria (Boston, Massachusetts); Jonathan Fay (Dexter, Michigan); Micha Rosen (Tzur Hadassah, Israel) |
| ABSTRACT | A device to transmit an audio signal to a user may comprise a mass, a piezoelectric transducer, and a support to support the mass and the piezoelectric transducer with the eardrum. The piezoelectric transducer can be configured to drive the support and the eardrum with a first force and the mass with a second force opposite the first force. The device may comprise circuitry configured to receive wireless power and wireless transmission of an audio signal, and the circuitry can be supported with the eardrum to drive the transducer in response to the audio signal, such that vibration between the circuitry and the transducer can be decreased. The transducer can be positioned away from the umbo of the ear to drive the eardrum, for example on the lateral process of the malleus. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/232070 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 11/02 (20130101) H04R 17/00 (20130101) H04R 23/008 (20130101) H04R 25/02 (20130101) H04R 25/65 (20130101) H04R 25/554 (20130101) H04R 25/606 (20130101) Original (OR) Class H04R 25/652 (20130101) H04R 2225/025 (20130101) H04R 2460/09 (20130101) H04R 2460/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210299106 | Dobi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert L. Dobi (Rockville, Maryland); Clifton L. Dalgard (Chevy Chase, Maryland); Shiv K. Srivastava (Potomac, Maryland) |
| ABSTRACT | Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II) wherein X, X1, X2, X3, X4 and X5, R1 through R4 and R9 are as described. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158930 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/426 (20130101) Original (OR) Class A61K 31/4402 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 245/00 (20130101) C07C 245/02 (20130101) C07C 245/04 (20130101) Heterocyclic Compounds C07D 277/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299123 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ting Zhang (Carmel, Indiana); Jing-Yuan Liu (Indianapolis, Indiana); Mingji Dai (West Lafayette, Indiana) |
| ABSTRACT | Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) A61K 31/4985 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299219 | Chauhan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil Chauhan (Cambridge, Massachusetts); Reza Dana (Newton, Massachusetts) |
| ABSTRACT | This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/1833 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/00 (20130101) C07K 14/4753 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299504 | Mahendra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); PCT Systems, Inc. (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaily Mahendra (Santa Monica, California); Shashank Singh Kalra (Los Angeles, California); Sharyl Maraviov (San Jose, California) |
| ABSTRACT | The present disclosure includes systems, devices, and methods for a reactor, such as a sonication reactor, for destruction of Per- and polyfluoroalkyl substances (PFASs). In one aspect of the disclosure, the reactor includes a housing having a base and one or more walls that cooperate to define a chamber and a transducer disposed the chamber. The transducer is configured to generate a plurality of sound waves such that when PFAS solution is disposed within the chamber, the sound waves propagate through the liquid and at least some of the one or more PFAS compounds are pyrolyzed or otherwise degraded. Other aspects and features are also claimed and described. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196981 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/13 (20130101) Original (OR) Class A62D 2101/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299666 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zhenwei Wei (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183691 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/02 (20130101) B01L 7/52 (20130101) Original (OR) Class B01L 2300/087 (20130101) B01L 2300/1894 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299676 | KANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Joo Hun KANG (Boston, Massachusetts); Donald E. INGBER (Boston, Massachusetts); Michael SUPER (Lexington, Massachusetts) |
| ABSTRACT | Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin). |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344540 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) B03C 1/002 (20130101) Original (OR) Class B03C 1/025 (20130101) B03C 1/286 (20130101) B03C 1/288 (20130101) B03C 1/0332 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299686 | Johnson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Scooter Johnson (Hyattsville, Maryland) |
| ABSTRACT | Disclosed is a closable container of a mesh material having openings. When the container is closed, the openings are the only gaps in the container. The openings are no more than 150 microns in diameter. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344486 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 7/24 (20130101) Original (OR) Class Processes for Applying Fluent Materials to Surfaces, in General B05D 1/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210299781 — PROCESS OF MAKING COMPONENTS FOR ELECTRONIC AND OPTICAL DEVICES USING LASER PROCESSING
| US 20210299781 | Glavin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Philip R. Buskohl (Beavercreek, Ohio); Kimberly A. Gliebe (Mentor, Ohio); Christopher Muratore (Kettering, Ohio); Drake Austin (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to processes of making components for electronic and optical devices using laser processing and devices comprising such components. Such process uses a laser to introduce chemical and/or structural changes in substrates and films that are the raw materials from which components for electronic and optical devices are made. Such process yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film. In addition, such process does not require large-scale clean rooms and is easily configurable. Thus, rapid device prototyping, design change and evolution in the lab and on the production side is realized. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/216729 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299789 | Glavin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Christopher Muratore (Kettering, Ohio) |
| ABSTRACT | The present invention relates to processes of making components for electronic and optical devices using laser processing and devices comprising such components. Such process uses a laser to introduce chemical and/or structural changes in substrates and films that are the raw materials from which components for electronic and optical devices are made. Such process yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film. In addition, such process does not require large-scale clean rooms and is easily configurable. Thus, rapid device prototyping, design change and evolution in the lab and on the production side is realized. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336894 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/40 (20130101) B23K 26/362 (20130101) Original (OR) Class B23K 2101/40 (20180801) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299962 | Qian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping Qian (Madison, Wisconsin); Cunfu Wang (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for controlling support structures and build orientation are provided. In some embodiments, a method for additive manufacturing a part using a three dimensional (3D) printing system, the 3D printing system including a print head and a build plate is provided, the method comprising: receiving a plurality of physical constraints associated with the part; optimizing a build orientation of the part to identify an optimized build orientation b* for the part with respect to a design domain defined by the physical constraints based on the plurality of physical constraints, and a plurality of design constraints using at least one variable associated with build orientation as an optimization variable, the plurality of design constraints comprising: an initial build orientation b0; and a critical surface slope angle and generating a part model based on the optimized build orientation b*. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 16/832244 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/40932 (20130101) G05B 2219/35012 (20130101) G05B 2219/35261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300433 | Vorobeychik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yevgeniy Vorobeychik (St. Louis, Missouri); Tong Wu (St. Louis, Missouri); Liang Tong (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Yevgeniy Vorobeychik (St. Louis, Missouri); Tong Wu (St. Louis, Missouri); Liang Tong (St. Louis, Missouri) |
| ABSTRACT | An image classification system defends against physically realizable attacks. A training dataset of input images is retrieved and an adversarial image is generated based on one of the input images that is selected. The adversarial image is created by occluding a portion of the selected image by superimposing a predetermined shape (e.g., a rectangle) containing noise on the selected image. A defense against occlusion attacks (DOA) classifier is trained using the training dataset and the adversarial image. The DOA classifier is utilized to classify captured images of items (e.g., street signs) that may have been attacked (e.g., sticker placement, vandalism). |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214071 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 60/00188 (20200201) Original (OR) Class B60W 2420/403 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6202 (20130101) G06K 9/6232 (20130101) G06K 9/6256 (20130101) G06K 9/6267 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300583 | Hinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Kimberly A. Hinson (Seattle, Washington); Jung Soon Jang (Bellevue, Washington); Blain A. Lawson (Tukwila, Washington); Christopher M. Jacobus (Saint Louis, Missouri) |
| ABSTRACT | Described are systems and methods for deploying and stowing a refueling boom. In certain examples, deploying the refueling boom includes lowering a refueling boom structure with a hoist while a boom aerodynamic control surface of the refueling is deactivated, determining that first transition conditions have been met, switching the hoist actuator state mode, and activating the boom aerodynamic control surface. In other examples, stowing the refueling boom includes flying the refueling boom towards a fuselage, determining that second transition conditions have been met, switching the hoist actuator state mode, and raising a refueling boom structure of the refueling boom with the hoist. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 16/835962 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 39/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300973 | LIGHTFOOT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YAIMA L. LIGHTFOOT (WASHINGTON, District of Columbia); BIKASH SAHAY (GAINESVILLE, Florida); MANSOUR MOHAMADZADEH (GAINESVILLE, Florida) |
| ABSTRACT | The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant L. acidophilus cells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinant L. acidophilus cells or SlpA isolated from L. acidophilus can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/747 (20130101) A61K 38/13 (20130101) A61K 38/164 (20130101) Peptides C07K 14/335 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/746 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300999 | CROWE, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | James E. CROWE, JR. (Nashville, Tennessee); Seth ZOST (Nashville, Tennessee); Robert CARNAHAN (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301078 | RUSH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Anthony M. RUSH (San Diego, California); Nathan GIANNESCHI (San Diego, California); Carrie JAMES (San Diego, California) |
| ABSTRACT | Provided herein are compositions and methods of making high density nucleic acid polymers. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172793 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Peptides C07K 14/003 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) Original (OR) Class C08G 2261/128 (20130101) C08G 2261/143 (20130101) C08G 2261/418 (20130101) C08G 2261/3324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301269 | Sanjana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York); New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neville E. Sanjana (New York, New York); Zharko Daniloski (New York, New York); Mateusz Legut (Jersey City, New Jersey) |
| ABSTRACT | Provided herein is a recombinant or engineered Cas9 protein. The Cas9 protein has an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO: 2. The Cas9 protein has at least one mutation in an amino acid residue selected from 262, 324, 409, 480, 543, 694, of the amino acid sequence provided in SEQ ID NO: 2 or the corresponding residue of an aligned sequence, and at least one mutation in an amino acid residue selected from 1111, 1135, 1218, 1219, 1322, 1335, and 1337, of the amino acid sequence provided in SEQ ID NO: 2 or the corresponding residue of an aligned sequence. The amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154826 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/1082 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301321 | Ellington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Yu Sherry Jiang (Austin, Texas); Sanchita Bhadra (Austin, Texas); Bingling Li (Austin, Texas); Randy Allen Hughes (Austin, Texas); Yan Du (Austin, Texas); Jimmy Gollihar (Hewitt, Texas) |
| ABSTRACT | Disclosed are methods for isothermal nucleic acid amplification and detection. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209600 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301326 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem F. ISMAGILOV (Altadena, California); Nathan G. SCHOEPP (Burlingame, California); Emily S. SAVELA (Pasadena, California); Eric J. LIAW (Pasadena, California); Alexander WINNETT (Pasadena, California); Matthew M. COOPER (Pasadena, California) |
| ABSTRACT | Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/164674 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301381 | Glavin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Philip R. Buskohl (Beavercreek, Ohio); Kimberly A. Gliebe (Mentor, Ohio); Christopher Muratore (Kettering, Ohio); Drake Austin (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to processes of making components for electronic and optical devices using laser processing and devices comprising such components. Such process uses a laser to introduce chemical and/or structural changes in substrates and films that are the raw materials from which components for electronic and optical devices are made. Such process yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film. In addition, such process does not require large-scale clean rooms and is easily configurable. Thus, rapid device prototyping, design change and evolution in the lab and on the production side is realized. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336855 |
| CURRENT CPC | Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/00 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/428 (20130101) H01L 21/463 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301734 | Hart et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Leo Hart (Loveland, Ohio); Adam Joseph Reese (Cincinnati, Ohio); Jeffrey Scott Gilton (Lebanon, Ohio) |
| ABSTRACT | A method for handling a simultaneous failure of all channels of a multi-channel engine controller configured to control operation of a gas turbine engine is provided. The method includes obtaining, by a first processor associated with a first channel of the engine controller, data indicative of the simultaneous failure of all channels of the engine controller. The method further includes providing, by the first processor, one or more control signals associated with resetting at least a second processor associated with a second channel of the multi-channel engine controller based, at least in part, on the data. Furthermore, the method includes controlling, by the first processor, operation of the gas turbine engine while at least the second processor is resetting. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 16/833870 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/00 (20130101) F02C 9/263 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2270/09 (20130101) F05D 2270/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302104 | Goodwin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Goodwin (Washington, District of Columbia); Evan Hyde (Washington, District of Columbia); Jesse Maxwell (Washington, District of Columbia); Kwok Cheung (Washington, District of Columbia); Robert Baldauff (Washington, District of Columbia); Triem Hoang (Laurel, Maryland) |
| ABSTRACT | A hybrid capillary and mechanically pumped loop heat pipe (HLHP) includes a fluid loop having, an evaporator thermally coupled to a heat load, a condenser thermally coupled to a heat sink, a reservoir, and one or more magnetically levitating pumps configured to pump fluid through the loop thereby improving heat transport capacity and system stability without compromising maintenance-free, long life operation of a conventional loop heat pipe. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210407 |
| CURRENT CPC | Non-positive-displacement Pumps F04D 29/058 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/025 (20130101) Original (OR) Class F28D 15/043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302116 | Shipley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Systems Corporation (Hunt Valley, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Andrew Shipley (Millers, Maryland); Cameron Mehdi Brand (Towson, Maryland); Kevin Michael Ayotte (Baltimore, Maryland); Joshua Stephen Ruck (Baltimore, Maryland); Benjamin Tyler Cole (Baltimore, Maryland); William Henry Engel, IV (Cockeysville, Maryland) |
| ABSTRACT | A firearm for firing cased telescoped (CT) ammunition cartridges that includes a split chamber configured to fully support a CT cartridge when it is fired, and that includes i) a dynamic rear chamber portion defining a pocket in a face of a bolt, and ii) a static front chamber portion that is integral to the barrel and separate from the bolt. A cartridge extraction mechanism engages the CT cartridge prior to the CT cartridge being fired, and holds the CT cartridge in the pocket in the bolt face as the bolt moves rearward to pull the CT cartridge out of the static front chamber portion and into an ejection position. An ejector is operable to eject the CT cartridge from the pocket in the face of the bolt when the CT cartridge reaches the ejection position. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229261 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 3/26 (20130101) F41A 15/14 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 5/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302134 | Galloway et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Galloway (Nashville, Tennessee); Kelsay E. Neely (Nashville, Tennessee); Aimee J. Valles (Nashville, Tennessee); Robert J. Clark (Nashville, Tennessee); Jesse L. Frederick (Nashville, Tennessee) |
| ABSTRACT | Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 16/987933 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 1/028 (20130101) Original (OR) Class F42B 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302226 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136933 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302231 | Mann |
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| FUNDED BY |
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| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Chris W. Mann (Austin, Texas) |
| ABSTRACT | A tunable notch filter for operation in reflection mode comprises an antenna layer positioned on a transmissive substrate and a mirror layer positioned on a support substrate. The antenna layer and the mirror layer are positioned on opposite sides of a gap and facing each other, the gap having a gap distance. The notch filter is tuned by adjusting the gap distance between the antenna layer and the mirror layer. Tuning the notch filter to a selected state can cause the filter to selectively attenuate the reflection of at least some electromagnetic radiation that is incident on the transmissive substrate and enters the notch filter. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210993 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/12 (20130101) G01J 3/44 (20130101) G01J 3/0227 (20130101) Original (OR) Class G01J 2003/1247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302287 | Zheng et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siyang Zheng (State College, Pennsylvania); Mauricio Terrones (State College, Pennsylvania); Yin-Ting Yeh (State College, Pennsylvania); Yi Tang (State College, Pennsylvania); Huaguang Lu (State College, Pennsylvania); Nestor Perea Lopez (State College, Pennsylvania); Yiqiu Xia (State College, Pennsylvania) |
| ABSTRACT | The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236814 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class G01N 1/4077 (20130101) G01N 33/552 (20130101) G01N 33/54346 (20130101) G01N 33/56983 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302297 | Mieras et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan S. Mieras (Wilmington, North Carolina); Jack A. Puleo (Newark, Delaware); Charles Key (Diamondhead, Mississippi); Edward F. Braithwaite (Covington, Louisiana); Joseph Calantoni (Diamondhead, Mississippi) |
| ABSTRACT | Systems and methods are provided for developing a self-contained conductivity concentration profiler (CCP) system for standalone coastal and ocean deployment. A self-contained CCP system in accordance with an embodiment of the present disclosure can measure sediment concentration profiles and track instantaneous bed levels in sandy environments to enable better understanding of small-scale sediment transport processes in the coastal and nearshore marine environment. A self-contained CCP system in accordance with an embodiment of the present disclosure can support unmanned and standalone deployment configuration, allowing for operation in previously unattainable areas of interest in which small-scale sediment transport processes are important but poorly understood. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211529 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0656 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302340 | Neill et al. |
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| FUNDED BY |
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| APPLICANT(S) | Justin L. NEILL (Charlottesville, Virginia); Matt MUCKLE (Earlysville, Virginia); Roger REYNOLDS (Charlottesville, Virginia); BrightSpec, Inc. (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin L. Neill (Charlottesville, Virginia); Matt Muckle (Earlysville, Virginia); Roger Reynolds (Charlottesville, Virginia) |
| ABSTRACT | Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 17/266260 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/085 (20130101) Original (OR) Class G01N 24/087 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302601 | INGLIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Silverside Detectors Inc (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew INGLIS (Brookline, Massachusetts); Alison Forsyth (Somerville, Massachusetts); Zachary S. Hartwig (Roslindale, Massachusetts); Philip C. Taber (Arlington, Massachusetts); Timothy Teal (Brighton, Massachusetts); Hidefumi Tomita (Pittsburgh, Pennsylvania) |
| ABSTRACT | A fissile neutron detection system includes an ionizing thermal neutron detector arrangement including an inner peripheral shape that at least substantially surrounds a moderator region for detecting thermal neutrons that exit the moderator region but is at least generally transparent to the incident fissile neutrons. A moderator is disposed within the moderator region having lateral extents such that any given dimension that bisects the lateral extents includes a length that is greater than any thickness of the moderator arrangement transverse to the lateral extents. The moderator can include major widthwise and major lengthwise lateral extents such that any given dimension across the lengthwise and widthwise lateral extents includes a length that is greater than any thickness of the moderator arrangement transverse to the lateral extents. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346894 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 3/00 (20130101) Original (OR) Class G01T 3/008 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/00 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 47/1233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302710 | Kolle et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mathias Kolle (Hull, Massachusetts); Cecile Chazot (Cambridge, Massachusetts) |
| ABSTRACT | Articles and systems for dark microscopy and related methods are generally described. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133159 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 5/08 (20130101) G02B 21/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302763 | Yao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Yu Yao (Chandler, Arizona); Ali Basiri (Tempe, Arizona) |
| ABSTRACT | An optical device is disclosed. The optical device includes a silicon substrate, an aluminum oxide layer, an aluminum layer between the silicon substrate and the aluminum oxide layer, and a metasurface nanostructure. The metasurface nanostructure may include a graphene monolayer on the aluminum oxide layer and an electrically conductive nanoantenna array in direct contact with the graphene monolayer, where each nanoantenna in the nanoantenna array may include multiple segments, each segment having one or more parameters selected to achieve simultaneous resonance in the mid-infrared and the near infrared spectral regions when the graphene monolayer is irradiated with a near infrared pump pulse and a continuous mid-infrared probe. The optical device generates mid-infrared pulses via ultrafast modulation of hot carriers in the monolayer graphene. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219607 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0147 (20130101) Original (OR) Class G02F 2202/30 (20130101) G02F 2203/10 (20130101) G02F 2203/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302767 | FARAON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei FARAON (Pasadena, California); Jake ROCHMAN (Pasadena, California); Tian XIE (Pasadena, California); John G. BARTHOLOMEW (Camperdown, Australia) |
| ABSTRACT | Systems and methods for providing a microwave-to-optical (M2O) transducer using magneto-optical field interactions with spin states of an ensemble of ions doped into a crystal structure is presented. According to one aspect, the crystal structure is a (171Yb3+:YVO) doped crystal structure that provides a substrate for an on-chip implementation of the transducer. According to one aspect, coupling of microwave and optical signals to the ions is based on respective microwave and optical waveguides fabricated in or on the doped crystal structure. According to another aspect, coupling of microwave and optical signals to the ions is based on respective microwave and optical resonant cavities fabricated in or on the doped crystal structure. Transduction can be based on either a three-level system with near-zero applied external magnetic field or on a four-level system with zero applied external magnetic field. The transducer can operate reversibly as an optical-to-microwave (O2M) transducer. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116131 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0036 (20130101) G02F 1/095 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210303306 | BUYUKTOSUNOGLU et al. |
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| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Alper BUYUKTOSUNOGLU (White Plains, New York); David TRILLA RODRIGUEZ (Barcelona, Spain); John-David WELLMAN (Hopewell Junction, New York); Pradip BOSE (Yorktown Heights, New York) |
| ABSTRACT | Embodiments for implementing optimized accelerators in a computing environment are provided. Selected instruction sequence code blocks derived from one or more application workloads may be consolidated together to activate one or more accelerators subject to one or more constraints and projections. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 16/836794 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/321 (20130101) G06F 9/30181 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304040 | Sides et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Sides (Leonardtown, Maryland); Guy Berry (East Aurora, New York) |
| ABSTRACT | A FOD mitigation method which includes the steps of: identifying an airfield that has an engine FOD problem; identifying physical parameters on the airfield that have an impact on engine FOD; setting sensors in and around the airfield to accurately collect data, wherein the sensors are capable of accurately measuring physical parameters that define the airfield and able to detect a FOD event; routing data from the sensors to a central location, sanitizing the data and fusing the data using time as an independent variable; predicting FOD events using the data such that FOD event predictions are made; evaluating the predictions to determine their accuracy and confidence, utilizing the predictions to characterize the risk of a FOD event on the airfield; and informing an airfield operator of relative risks and predictions. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/184750 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/045 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305315 | Solgun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Firat Solgun (Ossining, New York); Dongbing Shao (Briarcliff Manor, New York); Markus Brink (White Plains, New York) |
| ABSTRACT | A system includes a first quantum circuit plane that includes a first qubit, a second qubit and a third qubit. A coupled-line bus is coupled between the first qubit and the second qubit. A second circuit plane is connected to the first quantum circuit plane, comprising a control line coupled to the third qubit. The control line and the coupled-line bus are on different planes and crossing over each other, and configured to mitigate cross-talk caused by the crossing during signal transmission. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 16/833479 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305491 | Spanier et al. |
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| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); Bar-Ilan University (Ramat Gan, Israel); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan E. Spanier (Bala Cynwyd, Pennsylvania); Zongquan Gu (Chalfont, Pennsylvania); Ilya Grinberg (Bet Shemesh, Israel); Atanu Samanta (Ramat Gan, Israel); Haim Barak (Ramat Gan, Israel); Cedric J.G. Meyers (Oakland, California); Robert A. York (Oakland, California) |
| ABSTRACT | An article comprising a ferroelectric material in its ferroelectric phase, wherein the article is configured to enable low-loss propagation of signals with ultra-low dielectric loss at one or more select frequencies. |
| FILED | Thursday, August 01, 2019 |
| APPL NO | 17/264726 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/1871 (20130101) H01L 41/1876 (20130101) Original (OR) Class H01L 41/1878 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306075 | MORTON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Morton Photonics (West Friendship, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul A. MORTON (West Friendship, Maryland); Jacob KHURGIN (Pikesville, Maryland) |
| ABSTRACT | High-performance ultra-wideband Phased Array Antennas (PAA) are disclosed, having unique capabilities, enabled through photonic integrated circuits and novel optical architectures. Unique capabilities for PAA systems are enabled by photonic integration and ultra-low-loss waveguides. Novel aspects include optical multiplexing combining wavelength division multiplexing and/or a novel extension to array photodetectors, providing the capability to combine many RF photonic signals with very low loss. Architectures include tunable optical up-conversion and down-conversion systems, moving a chosen frequency band between baseband and a high RF frequency band with high dynamic range. Simultaneous multi-channel RF beamforming is achieved through power combining/splitting of optical signals. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224580 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/00 (20130101) Antennas, i.e Radio Aerials H01Q 3/2676 (20130101) Transmission H04B 10/40 (20130101) H04B 10/25759 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306227 | Atighetchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Hassan Atighetchi (Framingham, Massachusetts); Stephane Yannick Blais (Framingham, Massachusetts); Samuel Cunningham Nelson (Sudbury, Massachusetts) |
| ABSTRACT | Techniques for metadata-based information provenance are disclosed. A node in a data provisioning layer receives encrypted payload data to be delivered to a recipient. The node generates provenance metadata that describes at least one action taken by the node with respect to the encrypted payload data. The node transmits the encrypted payload data and the provenance metadata via the data provisioning layer toward the recipient. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 16/832039 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/907 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/28 (20130101) Original (OR) Class H04L 63/107 (20130101) H04L 63/205 (20130101) H04L 67/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306564 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juejun Hu (Newton, Massachusetts); Tian GU (Fairfax, Virginia); Mikhail Shalaginov (Somerville, Massachusetts) |
| ABSTRACT | Wide-angle optical functionality is beneficial for imaging and image projection devices. Conventionally, wide-angle operation is attained by a complicated assembly of optical elements. Recent advances have led to meta-surface lenses or meta-lenses, which are ultra-thin planar lenses with nanoantennas that control the phase, amplitude, and/or polarization of light. Here, we present a meta-lens capable of diffraction-limited focusing and imaging over an unprecedented >170° angular field of view (FOV). The lens is integrated on a one-piece flat substrate and includes an aperture on one side and a single meta-surface on the other side. The meta-surface corrects third-order Seidel aberrations, including coma, astigmatism, and field curvature. The meta-lens has a planar focal plane, which enables considerably simplified system architectures for imaging and projection. The meta-lens design is generic and can be readily adapted to different meta-atom geometries and wavelength ranges to meet diverse application demands. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209496 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 13/06 (20130101) Pictorial Communication, e.g Television H04N 5/23238 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210298610 | Hocking et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle M. Hocking (Nashville, Tennessee); Colleen M. Brophy (Nashville, Tennessee); Susan S. Eagle (Nashville, Tennessee); Grant Hocking (Nashville, Tennessee) |
| ABSTRACT | A method embodiment includes generating, via a sensor of a computing device, a signal representing vibrations originating from a blood vessel of a subject and decomposing the signal into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes. The one or more first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the one or more second intrinsic oscillatory modes. The method includes obtaining an intensity spectrum of the one or more first intrinsic oscillatory modes over a range of frequencies and using the obtained intensity spectrum to determine a blood volume status of the subject. Another method embodiment includes using the one or more second intrinsic oscillatory modes to determine one or more mechanical properties of the blood vessel or tissue adjacent to the blood vessel. |
| FILED | Friday, May 10, 2019 |
| APPL NO | 17/054101 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0295 (20130101) A61B 5/681 (20130101) A61B 5/742 (20130101) A61B 5/02007 (20130101) Original (OR) Class A61B 5/02014 (20130101) A61B 5/7275 (20130101) A61B 2562/0247 (20130101) A61B 2562/0261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298659 | Grover et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pulkit Grover (Pittsburgh, Pennsylvania); Alireza Chamanzar (Pittsburgh, Pennsylvania); Marlene Behrmann Cohen (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel method for using the widely-used electroencephalography (EEG) systems to detect and localize silences in the brain is disclosed. The method detects the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. This method can also be used for reduced activity localization, activity level mapping throughout the brain, as well as mapping activity levels in different frequency bands. By accounting for the contributions of different sources to the power of the recorded signals, and using a hemispheric baseline approach and a convex spectral clustering framework, the method permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183545 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/372 (20210101) Original (OR) Class A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298769 | Pak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Nikita Pak (Allston, Massachusetts); Justin P. Kinney (Quincy, Massachusetts); Edward S. Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatice control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/088494 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1695 (20130101) Original (OR) Class A61B 34/30 (20160201) A61B 34/32 (20160201) A61B 90/10 (20160201) A61B 2017/00026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298780 | Ateshian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerard Agop Ateshian (New York, New York); Brandon Kendrick Zimmerman (Narvon, Pennsylvania); Courtney Adair Shaeffer (Holladay, Utah); Melvin P. Rosenwasser (Palisades, New York) |
| ABSTRACT | A Surgical forceps device comprising a pair of shanks and a clamping jaw portion, the clamping jaw surfaces set at an angle that produces a desired angular position for grasping a bendable osteochondral allograft. |
| FILED | Tuesday, April 20, 2021 |
| APPL NO | 17/235899 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/2909 (20130101) Original (OR) Class A61B 2017/2808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298983 | Deshpande et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashish Warren Deshpande (Austin, Texas); Bongsu Kim (Austin, Texas) |
| ABSTRACT | A robotic exoskeleton comprising a back portion providing at least two degrees of freedom, two shoulder portions, each shoulder portion providing at least five degrees of freedom, two elbow portions, each elbow portion providing at least one degree of freedom, and two forearm portions, each forearm portion providing at least one degree of freedom. Associated robotic forearm joints and robotic shoulder joints are also addressed. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346392 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/54 (20130101) A61F 2/76 (20130101) A61F 2/78 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/02 (20130101) Original (OR) Class A61H 1/0274 (20130101) A61H 1/0277 (20130101) A61H 1/0281 (20130101) A61H 2201/165 (20130101) A61H 2201/1207 (20130101) A61H 2201/1215 (20130101) A61H 2201/1454 (20130101) A61H 2201/1481 (20130101) A61H 2201/1614 (20130101) A61H 2201/1616 (20130101) A61H 2201/1619 (20130101) A61H 2201/1621 (20130101) A61H 2201/1638 (20130101) A61H 2201/1676 (20130101) A61H 2201/5058 (20130101) A61H 2201/5061 (20130101) A61H 2201/5064 (20130101) A61H 2201/5069 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299281 | Yuan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baohong Yuan (Arlington, Texas) |
| ABSTRACT | A method of imaging cancer stem cells comprises disposing a population of first ultrasound-switchable fluorophorms having a first switching threshold in the biological environment, the first ultrasound-switchable fluorophores being functionalized for attachment to a first biomarker expressed by the CSCs; disposing a population of second ultrasound-switchable fluorophorms having a second switching threshold in the biological environment, the second ultrasound-switchable fluorophores being functionalized for attachment to a second biomarker expressed by the CSCs; exposing the biological environment to an ultrasound beam to form an activation region; disposing one or more of the first and/or second ultrasound-switchable fluorophores in the activation region to switch the first and/or second fluorophores from an off state to an on state; exciting the first and second ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation; and detecting light emitted by the first and second ultrasound-switchable fluorophores. |
| FILED | Wednesday, July 17, 2019 |
| APPL NO | 17/260759 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0097 (20130101) A61B 5/489 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) Original (OR) Class A61K 49/0091 (20130101) A61K 49/0093 (20130101) A61K 49/222 (20130101) A61K 49/223 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/542 (20130101) G01N 33/582 (20130101) G01N 33/57492 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299666 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zhenwei Wei (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183691 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/02 (20130101) B01L 7/52 (20130101) Original (OR) Class B01L 2300/087 (20130101) B01L 2300/1894 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299916 | Derbyshire |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HUMMINGBIRD NANO, INC. (Nicholasville, Kentucky) |
| ASSIGNEE(S) | Hummingbird Nano, Inc. (Nicholasville, Kentucky) |
| INVENTOR(S) | Eleanor A. Derbyshire (Lexington, Kentucky) |
| ABSTRACT | A method for molding a part is disclosed wherein a molding material has a minimum viscosity. A substrate that is responsive to a magnetic or electric field is introduced to the molding material. The substrate is moved by a magnetic or electric field to form channels in the molding material. The molding material is cured during or after the channels are formed. |
| FILED | Friday, August 09, 2019 |
| APPL NO | 17/266668 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/0805 (20130101) B29C 39/42 (20130101) Original (OR) Class B29C 2035/0827 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/756 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299962 | Qian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoping Qian (Madison, Wisconsin); Cunfu Wang (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods, and media for controlling support structures and build orientation are provided. In some embodiments, a method for additive manufacturing a part using a three dimensional (3D) printing system, the 3D printing system including a print head and a build plate is provided, the method comprising: receiving a plurality of physical constraints associated with the part; optimizing a build orientation of the part to identify an optimized build orientation b* for the part with respect to a design domain defined by the physical constraints based on the plurality of physical constraints, and a plurality of design constraints using at least one variable associated with build orientation as an optimization variable, the plurality of design constraints comprising: an initial build orientation b0; and a critical surface slope angle and generating a part model based on the optimized build orientation b*. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 16/832244 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/40932 (20130101) G05B 2219/35012 (20130101) G05B 2219/35261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300009 | Wardle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Brian L. Wardle (Lexington, Massachusetts); Anastasios John Hart (Waban, Massachusetts); Enrique J. Garcia (Zaragoza, Spain); Alexander H. Slocum (Bow, New Hampshire) |
| ABSTRACT | The present invention provides methods for uniform growth of nanostructures such as nanotubes (e.g., carbon nanotubes) on the surface of a substrate, wherein the long axes of the nanostructures may be substantially aligned. The nanostructures may be further processed for use in various applications, such as composite materials. For example, a set of aligned nanostructures may be formed and transferred, either in bulk or to another surface, to another material to enhance the properties of the material. In some cases, the nanostructures may enhance the mechanical properties of a material, for example, providing mechanical reinforcement at an interface between two materials or plies. In some cases, the nanostructures may enhance thermal and/or electronic properties of a material. The present invention also provides systems and methods for growth of nanostructures, including batch processes and continuous processes. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/163936 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 37/02 (20130101) Original (OR) Class Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 1/00 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/18 (20170801) C01B 32/162 (20170801) C01B 2202/08 (20130101) C01B 2202/36 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/005 (20130101) C08J 2363/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/127 (20130101) D01F 9/133 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) Technical Subjects Covered by Former US Classification Y10T 156/10 (20150115) Y10T 428/24 (20150115) Y10T 428/269 (20150115) Y10T 428/292 (20150115) Y10T 428/2933 (20150115) Y10T 428/24994 (20150401) Y10T 428/24995 (20150401) Y10T 428/249942 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300433 | Vorobeychik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yevgeniy Vorobeychik (St. Louis, Missouri); Tong Wu (St. Louis, Missouri); Liang Tong (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Yevgeniy Vorobeychik (St. Louis, Missouri); Tong Wu (St. Louis, Missouri); Liang Tong (St. Louis, Missouri) |
| ABSTRACT | An image classification system defends against physically realizable attacks. A training dataset of input images is retrieved and an adversarial image is generated based on one of the input images that is selected. The adversarial image is created by occluding a portion of the selected image by superimposing a predetermined shape (e.g., a rectangle) containing noise on the selected image. A defense against occlusion attacks (DOA) classifier is trained using the training dataset and the adversarial image. The DOA classifier is utilized to classify captured images of items (e.g., street signs) that may have been attacked (e.g., sticker placement, vandalism). |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214071 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 60/00188 (20200201) Original (OR) Class B60W 2420/403 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6202 (20130101) G06K 9/6232 (20130101) G06K 9/6256 (20130101) G06K 9/6267 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301035 | Salas de la Cruz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Rowan University (Glasssboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Salas de la Cruz (Camden, New Jersey); Xiao Hu (Glassboro, New Jersey); Stacy Love (Camden, New Jersey); David Verrill (Camden, New Jersey) |
| ABSTRACT | The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218372 |
| CURRENT CPC | Separation B01D 71/10 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/447 (20130101) Polysaccharides; Derivatives Thereof C08B 15/08 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 3/042 (20170501) C08K 11/00 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) C08L 67/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301108 | Sinclair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Taproot Medical Technologies, LLC (Seattle, Washington) |
| ASSIGNEE(S) | Taproot Medical Technologies, LLC (Seattle, Washington) |
| INVENTOR(S) | Andrew William Sinclair (Seattle, Washington); Timothy James Fujihara (Seattle, Washington) |
| ABSTRACT | Disclosed are hydrogel compositions comprising both polysaccharide-based and polyzwitterionic components, methods of making the compositions, and methods of using the compositions for various clinical and biomedical applications. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/042 (20130101) A61K 8/735 (20130101) A61K 9/06 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) A61L 2430/34 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2305/08 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301249 | Shi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Shi (Lexington, Kentucky); Ryan M. Kalinoski (Oak Forest, Illinois) |
| ABSTRACT | The present disclosure includes a composition and a method for inhibiting bacteria growth. In particular, the present disclosure includes a composition for inhibiting lactic acid bacteria growth in a media contaminated by, or at risk of being contaminated by, one or more species of lactic acid bacteria. The composition comprises a decomposition product, such as a bio-oil, derived from an oxidative depolymerized lignin sample and includes one or more phenolic constituents. The method includes implementing the decomposition product into a media contaminated by, or at risk of being contaminated by, lactic acid bacteria in a concentration to inhibit growth of one or more species of lactic acid bacteria in the media. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219111 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 2500/30 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301411 | Manthiram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Karthish Manthiram (Cambridge, Massachusetts); Nikifar Lazouski (Boston, Massachusetts) |
| ABSTRACT | A system and method for supplying a gas to an electrochemical system is described. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211235 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/27 (20210101) C25B 1/50 (20210101) C25B 9/19 (20210101) C25B 11/032 (20210101) Original (OR) Class C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302226 | ZHOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136933 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302334 | ROS et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra ROS (Phoenix, Arizona); Daihyun KIM (Mesa, Arizona); Austin ECHELMEIER (Tempe, Arizona); Jorvani CRUZ VILLARREAL (Tempe, Arizona); Ana EGATZ-GOMEZ (Phoenix, Arizona); Sebastian QUINTANA (Phoenix, Arizona) |
| ABSTRACT | Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220357 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/0241 (20130101) B01L 3/50273 (20130101) B01L 2300/0867 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20025 (20130101) Original (OR) Class G01N 2223/602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302623 | Guler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Urcan Guler (West Lafayette, Indiana); Alexander V. Kildishev (West Lafayette, Indiana); Krishnakali Chaudhury (West Lafayette, Indiana); Shaimaa Azzam (West Lafayette, Indiana); Esteban E. Marinero-Caceres (West Lafayette, Indiana); Harsha Reddy (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir M. Shalaev (West Lafayette, Indiana) |
| ABSTRACT | An optical sensor system, comprising refractory plasmonic elements that can withstand temperatures exceeding 2500° C. in chemically aggressive and harsh environments that impose stress, strain and vibrations. A plasmonic metamaterial or metasurface, engineered to have a specific spectral and angular response, exhibits optical reflection characteristics that are altered by varying physical environmental conditions including but not limited to temperature, surface chemistry or elastic stress, strain and other types of mechanical load. The metamaterial or metasurface comprises a set of ultra-thin structured layers with a total thickness of less than tens of microns that can be deployed onto surfaces of devices operating in harsh environmental conditions. The top interface of the metamaterial or metasurface is illuminated with a light source, either through free space or via an optical fiber, and the reflected signal is detected employing remote detectors. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 16/835302 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/8422 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302710 | Kolle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mathias Kolle (Hull, Massachusetts); Cecile Chazot (Cambridge, Massachusetts) |
| ABSTRACT | Articles and systems for dark microscopy and related methods are generally described. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133159 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 5/08 (20130101) G02B 21/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210303591 | Fleming et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee Fleming (Orinda, California); Guan-Cheng Li (Albany, California) |
| ABSTRACT | Disclosed are methods and systems that help to visualize large groups of documents in a virtual reality or augmented reality environment comprising a three-dimensional (3D) space. An example method involves a computing device: determining a group of elements based at least in part on the one or more input parameters; determining one or more attributes based at least in part on the one or more parameters, the group of elements, or both; determining, for each element from the group, a respective location in a 3D space, based on one or more of the attributes; displaying a 3D graphical environment representing the 3D space, wherein each element from the group is represented in the 3D graphical environment by a graphic object at its respectively determined location in the 3D space; and enabling user interaction with the graphic objects in the 3D graphical environment. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218819 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/017 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) G06F 3/04815 (20130101) G06F 16/26 (20190101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/206 (20130101) G06T 19/00 (20130101) G06T 19/003 (20130101) G06T 19/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210303760 | Agonafer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Damena Agonafer (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Damena Agonafer (St. Louis, Missouri) |
| ABSTRACT | System and methods for forming a micropillar array for an evaporative heat exchanger include selecting a preliminary shape for a micropillar, determining a droplet shape that is generated by the preliminary shape, and generating at least one curve that defines the droplet shape. The system and methods also include performing an evaporative simulation based on the curve and selecting a final micropillar shape based on the evaporative simulation. The system and methods further include fabricating an array of micropillars including at least one micropillar having the final micropillar shape. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203677 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/23 (20200101) G06F 30/25 (20200101) Original (OR) Class G06F 30/28 (20200101) G06F 2113/08 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304051 | BROWN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth R. BROWN (Durham, North Carolina); Pak Hong LEUNG (Durham, North Carolina); Shilin HUANG (Durham, North Carolina); Bichen ZHANG (Durham, North Carolina) |
| ABSTRACT | A system includes a controller configured to reconstitute a continuous waveform to a discrete analogue version. The system includes a numerical optimizer configured to determine frequencies of a pulse sequence. The numerical optimizer uses radial motional mode frequencies and a desired gate time. The numerical optimizer generates the pulse sequence by closing phase-space trajectories, disentangling spins and motions, and constraining a Rabi frequency for motional sideband transitions. The system also includes a display configured to illustrate a discrete frequency modulation pulse sequence based on the determined frequencies. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212678 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 3/026 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304848 | Buhler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy Daniel Buhler (St. Louis, Missouri); Roger Dean Chamberlain (St. Louis, Missouri); Mark Allen Franklin (St. Louis, Missouri); Kwame Gyang (St. Louis, Missouri); Arpith Chacko Jacob (St. Louis, Missouri); Praveen Krishnamurthy (St. Louis, Missouri); Joseph Marion Lancaster (St. Louis, Missouri) |
| ABSTRACT | Apparatuses and methods are disclosed for comparing a first biosequence string with a second biosequence string to assess similarity between those biosequence strings. For example, a field programmable gate array (FPGA) can be used to (1) detect substrings of the second biosequence string that are matches to substrings of the first biosequence string, and (2) map the detected substrings of the second biosequence string to corresponding positions in the first biosequence string where the detected substrings are located based on a data structure that links substrings of the first biosequence string to positions in the first biosequence string where the substrings of the first biosequence string are located. These operations can be used to seed an alignment between the first and second biosequence strings that permits comparisons to be performed over longer substrings of the first and second biosequence strings so that similarities between those longer substrings can be quantified. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209464 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2255 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 50/00 (20190201) G16B 50/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304949 | SULLIVAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles R. SULLIVAN (West Lebanon, New Hampshire); Aaron L. F. STEIN (West Lebanon, New Hampshire); Phyo Aung KYAW (West Lebanon, New Hampshire) |
| ABSTRACT | A resonant coil with integrated capacitance includes at least one separation dielectric layer and a plurality of conductor layers stacked in an alternating manner. Each of the plurality of conductor layers includes a first conductor sublayer and second conductor sublayer having common orientation and a sublayer dielectric layer separating the first and second conductor sublayers. Adjacent conductor layers of the plurality of conductor layers have different orientations. |
| FILED | Friday, July 21, 2017 |
| APPL NO | 16/319633 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/006 (20130101) H01F 27/24 (20130101) H01F 27/323 (20130101) H01F 27/2804 (20130101) Original (OR) Class H01F 2027/2809 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305862 | Losey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley Losey (Columbus, Ohio); Marcelo Dapino (Columbus, Ohio) |
| ABSTRACT | An exemplary axial cladding magnet magnetically-geared machine is disclosed comprising Halbach array cladding magnets located on the axial ends of the magnetically-geared machine. The Halbach array cladding magnets can be used to increase the magnetic efficiency and torque transmission of the magnetically-geared machine by mitigating end-effect losses. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213671 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/2786 (20130101) Original (OR) Class H02K 3/28 (20130101) H02K 16/02 (20130101) H02K 29/03 (20130101) H02K 2213/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305999 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zhikang Zhang (Mesa, Arizona); Fengbo Ren (Tempe, Arizona); Kai Xu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Zhikang Zhang (Mesa, Arizona); Fengbo Ren (Tempe, Arizona); Kai Xu (Tempe, Arizona) |
| ABSTRACT | A compression ratio (CR) adapter (CRA) for end-to-end data-driven compressive sensing (CS) reconstruction (EDCSR) frameworks is provided. EDCSR frameworks achieve state-of-the-art reconstruction performance in terms of reconstruction speed and accuracy for images and other signals. However, existing EDCSR frameworks cannot adapt to a variable CR. For applications that desire a variable CR, existing EDCSR frameworks must be trained from scratch at each CR, which is computationally costly and time-consuming. Embodiments described herein present a CRA framework that addresses the variable CR problem generally for existing and future EDCSR frameworks with no modification to given reconstruction models nor enormous additional rounds of training needed. The CRA exploits an initial reconstruction network to generate an initial estimate of reconstruction results based on a small portion of acquired image measurements. Subsequently, the CRA approximates full measurements for the main reconstruction network by complementing the sensed measurements with a re-sensed initial estimate. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218738 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) Coding; Decoding; Code Conversion in General H03M 7/6047 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306042 | Bshara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Oday Bshara (Philadelphia, Pennsylvania); Vasil Pano (Philadelphia, Pennsylvania); Md Abu Saleh Tajin (Philadelphia, Pennsylvania); Kapil R. Dandekar (Philadelphia, Pennsylvania) |
| ABSTRACT | Low latency beamforming using phased antenna arrays is the key for practical deployment of envisioned millimeter wave (mmWave) Gbps mobile networks. This work aims towards reducing the overhead of the exhaustive sector-level sweep phase of the analog beamforming adopted in the IEEE 802.11ad standard. This system uses a reconfigurable antenna single RF chain in the sub-6 GHz new radio (NR) band to aid codebook-based beam selection in the mmWave band of the NR. The system exploits the congruence between the spatial propagation signatures of signals at both mmWave and sub-6 GHz frequencies to reduce the beam search space. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213930 |
| CURRENT CPC | Transmission H04B 7/0456 (20130101) H04B 7/0491 (20130101) H04B 7/0617 (20130101) Original (OR) Class H04B 7/0695 (20130101) Wireless Communication Networks H04W 16/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306080 | Abdi |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ali Abdi (Short Hills, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Abdi (Short Hills, New Jersey) |
| ABSTRACT | A method and a system are disclosed for high speed acoustic transmission of data in networks and sequences of solid pieces using various propagation modes. The data is converted to several sets, and then the sets are transmitted via propagation modes such as extensional or flexural or torsional or their combinations, using multiple transmitters. This allows to increase transmission rate or reduce transmission error or both for data communication. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269723 |
| CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101) Transmission H04B 11/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210299633 | Baumann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore F. Baumann (Discovery Bay, California); Joe H. Satcher, Jr. (Patterson, California); Joseph C. Farmer (Tracy, California); Todd Bandhauer (Livermore, California) |
| ABSTRACT | A highly adsorptive structure includes: a substrate; and a metal-organic framework (MOF) comprising a plurality of metal atoms coordinated to a plurality of organic spacer molecules; wherein the MOF is coupled to at least one surface of the substrate, wherein the MOF is configured to adsorb and desorb a refrigerant under predetermined thermodynamic conditions. The refrigerant includes one or more materials selected from the group consisting of: acid halides, alcohols, aldehydes, amines, chlorofluorocarbons, esters, ethers, fluorocarbons, perfluorocarbons, halocarbons, halogenated aldehydes, halogenated amines, halogenated hydrocarbons, halomethanes, hydrocarbons, hydrochlorofluorocarbons, hydrofluoroethers, hydrofluoroolefins, inorganic gases, ketones, nitrocarbon compounds, noble gases, organochlorine compounds, organofluorine compounds, organophosphorous compounds, organosilicon compounds, oxide gases, refrigerant blends and thiols. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199251 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3265 (20130101) B01J 20/28042 (20130101) B01J 20/28066 (20130101) B01J 20/28097 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 15/00 (20130101) F25B 17/083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299649 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sangwoo LEE (Cohoes, New York); Chulsung BAE (Cohoes, New York); Carrie Lynn TRANT (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Sangwoo LEE (Cohoes, New York); Chulsung BAE (Cohoes, New York); Carrie Lynn TRANT (Troy, New York) |
| ABSTRACT | An anion exchange membrane is composed of a copolymer of 1,1-diphenylethylene and one or more styrene monomers, such as 4-tert-butylstyrene. The copolymer includes a backbone substituted with a plurality of ionic groups coupled to phenyl groups on the backbone via hydrocarbyl tethers between about 1 and about 7 carbons in length. High-temperature conditions enabled by these copolymers enhance conductivity performance, making them particularly suitable for use in anion exchange membranes in fuel cells, electrolyzers employing hydrogen, ion separations, etc. The properties of the membranes can be tuned via the degree of functionalization of the phenyl groups and selection of the functional groups, such as quaternary ammonium groups. Several processes can be used to incorporate the desired ionic functional groups into the polymers, such as chloromethylation, radical bromination, Friedel-Crafts acylation and alkylation, sulfonation followed by amination, or combinations thereof. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208364 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/14 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 212/08 (20130101) C08F 212/32 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) C08J 2325/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299650 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Zhongyang Wang (St. Louis, Missouri); Shrihari Sankarasubramanian (St. Louis, Missouri); Vijay K. Ramani (St. Louis, Missouri); Yunzhu Zhang (St. Louis, Missouri); Javier Parrondo (St. Louis, Missouri) |
| ABSTRACT | Anion exchange membranes (AEMs) for separators in electrochemical devices and methods for making same are disclosed herein. AEMs include chloromethylated SEBS triblock copolymer functionalized with TRIS cations and chloromethylated QPEK-C functionalized with TMA cations. Composite AEMs further include metal oxide fillers. Reinforced AEMs and reinforced composite AEMs further include a reinforcement material base. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/264016 |
| CURRENT CPC | Separation B01D 61/44 (20130101) B01D 69/12 (20130101) B01D 71/80 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/07 (20170101) B01J 41/14 (20130101) Original (OR) Class B01J 47/12 (20130101) B01J 47/018 (20170101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2243 (20130101) C08J 2353/00 (20130101) C08J 2427/18 (20130101) Compositions of Macromolecular Compounds C08L 53/005 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/0221 (20130101) H01M 8/0226 (20130101) H01M 2300/0082 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299749 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Liliang Huang (Evanston, Illinois); Haixin Lin (Evanston, Illinois) |
| ABSTRACT | Provided herein are methods of preparing tetrahexahedra nanoparticles and methods of using the tetrahexahedra nanoparticles as an oxidative catalyst. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/263832 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) B22F 1/0044 (20130101) B22F 9/18 (20130101) Original (OR) Class B22F 9/30 (20130101) B22F 2001/0037 (20130101) B22F 2301/25 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/01 (20210101) C25B 1/23 (20210101) C25B 11/089 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300328 | Narula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CUMMINS INC. (Columbus, Indiana) |
| ASSIGNEE(S) | CUMMINS INC. (Columbus, Indiana) |
| INVENTOR(S) | Manik Narula (Columbus, Indiana); Timothy C. Ernst (Columbus, Indiana); Michael J. Ruth (Franklin, Indiana); Jonathan A. Dickson (Columbus, Indiana); J. Steven Kolhouse (Columbus, Indiana); Nimish Bagayatkar (Carmel, Indiana) |
| ABSTRACT | A waste heat recovery (WHR) hybrid power system can be utilized in vehicles to convert heat energy into mechanical energy. The WHR system can include a WHR power unit structured to convert thermal energy into rotation of a WHR drive shaft. A motor/generator having a motor/generator shaft can selectively operate as a motor or a generator. A mechanical linkage can be structured to selectively link a output shaft to one of the WHR drive shaft and the motor/generator drive shaft independently of the other of the WHR drive shaft and the motor/generator drive shaft. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229438 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/26 (20130101) B60K 6/44 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/14 (20160101) Original (OR) Class B60W 30/18127 (20130101) Gas-flow Silencers or Exhaust Apparatus for Machines or Engines in General; Gas-flow Silencers or Exhaust Apparatus for Internal Combustion Engines F01N 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300799 | Lopez-Ruiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Juan A. Lopez-Ruiz (Richland, Washington); Jonathan D. Egbert (Richland, Washington); Charles J. Freeman (West Richland, Washington); Oliver Y. Gutiérrez Tinoco (Richland, Washington); Jamelyn D. Holladay (Kennewick, Washington); Daniel T. Howe (Pasco, Washington); Yang Qiu (Richland, Washington); Ismael A. Rodriguez Perez (Richland, Washington) |
| ABSTRACT | An anode, a flow cell including the anode, and a method for electrocatalytic treatment of bio-oil and/or wastewater are disclosed. The anode comprises RuO2 particles on a titanium support. The method includes flowing a process stream through the flow cell in the absence of added hydrogen, at a temperature of 0° C. to 50° C. and atmospheric pressure, and applying a potential across the flow cell such that the anode is positive with respect to the cathode, thereby electrocatalytically oxidizing compounds in the process stream to produce a treated process stream at the anode and generating hydrogen gas as a byproduct at the cathode. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213810 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/462 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4672 (20130101) Original (OR) Class C02F 1/46114 (20130101) C02F 2001/46142 (20130101) C02F 2101/32 (20130101) C02F 2101/34 (20130101) C02F 2101/38 (20130101) C02F 2101/40 (20130101) C02F 2301/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300876 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rhia M Martin (Arvada, Colorado); Douglas L. Gin (Longmont, Colorado); Richard D Noble (Boulder, Colorado); Vinh The Nguyen (Arvada, Colorado); Brian J Elliott (Superior, Colorado) |
| ABSTRACT | A polymerizable Gemini surfactant based on tail groups with mixed isomer dienes. The Gemini surfactants may be produced having imidazolium head groups and diene tail groups with a near-equal abundance of the “E” and “Z” isomers. These compounds are lyotropic liquid crystals that can form bicontinuous cubic phases by self-assembly. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259467 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/58 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/52 (20130101) C09K 2019/528 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301085 | Bara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason E. Bara (Tuscaloosa, Alabama); Kathryn E. O'Harra (Tuscaloosa, Alabama); Irshad Kammakakam (Tuscaloosa, Alabama) |
| ABSTRACT | Disclosed are compositions derived from 2,2′bisimidazoles building blocks and methods of making the same. The disclosed compositions are capable of withstanding temperatures up to 600° C. and substantially flame resistant. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154451 |
| CURRENT CPC | Heterocyclic Compounds C07D 235/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0616 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 79/04 (20130101) C08L 2205/025 (20130101) C08L 2205/035 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302226 | ZHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin ZHOU (Fremont, California); Alexander K. ZETTL (Kensington, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136933 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 3/12 (20130101) G01H 11/06 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 15/104 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 1/08 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302295 | LINNEEN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | X ENERGY, LLC (Rockville, Maryland) |
| ASSIGNEE(S) | X Energy, LLC (, None) |
| INVENTOR(S) | Nicholas LINNEEN (Knoxville, Tennessee) |
| ABSTRACT | Metal oxide gel particles, may be prepared with a desired particle size, by preparing a low-temperature aqueous metal nitrate solution containing hexamethylene tetramine as a feed solution; and causing the feed solution to flow through a first tube and exit the first tube as a first stream at a first flow rate, so as to contact a high-temperature nonaqueous drive fluid. The drive fluid flows through a second tube at a second flow rate. Shear between the first stream and the drive fluid breaks the first stream into particles of the metal nitrate solution, and decomposition of hexamethylene tetramine converts metal nitrate solution particles into metal oxide gel particles. A metal oxide gel particle size is measured optically, using a sensor device directed at a flow of metal oxide gel particles within the stream of drive fluid. The sensor device measures transmission of light absorbed by either the metal oxide gel particles or the drive fluid, so that transmission of light through the drive fluid changes for a period of time as a metal oxide gel particle passes the optical sensor. If a measured particle size is not about equal to a desired particle size, the particle size may be corrected by adjusting a ratio of the first flow rate to a total flow rate, where the total flow rate is the sum of the first and second flow rates. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215691 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/12 (20130101) G01N 15/0205 (20130101) Original (OR) Class G01N 2011/008 (20130101) G01N 2015/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302452 | Giera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Giera (Oakland, California); Eric B. Duoss (Dublin, California); Du Nguyen (Fremont, California); William Smith (Oakland, California); Sachin Subhash Talathi (Pleasanton, California); Aaron Creighton Wilson (Livermore, California); Congwang Ye (Livermore, California) |
| ABSTRACT | A system is provided to automatically monitor and control the operation of a microfluidic device using machine learning technology. The system receives images of a channel of a microfluidic device collected by a camera during operation of the microfluidic device. Upon receiving an image, the system applies a classifier to the image to classify the operation of the microfluidic device as normal, in which no adjustment to the operation is needed, or as abnormal, in which an adjustment to the operation is needed. When an image is classified as normal, the system may make no adjustment to the microfluidic device. If, however, an image is classified as abnormal, the system may output an indication that the operation is abnormal, output an indication of a needed adjustment, or control the microfluidic device to make the needed adjustment. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344183 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502784 (20130101) B01L 2200/143 (20130101) B01L 2200/0652 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/00 (20130101) G01N 15/1429 (20130101) G01N 15/1475 (20130101) G01N 35/00623 (20130101) G01N 35/00871 (20130101) Original (OR) Class G01N 2015/149 (20130101) G01N 2035/00643 (20130101) G01N 2035/00881 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) G05B 2219/37333 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0635 (20130101) G05D 7/0694 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210304933 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Tang (Ames, Iowa); Gaoyuan Ouyang (Ames, Iowa); Baozhi Cui (Ames, Iowa); Jun Cui (Ames, Iowa) |
| ABSTRACT | A synthesis process is disclosed for fabrication of mass quantities of high-purity α-MnBi magnetic powder and subsequent bulk permanent magnet. An illustrative process includes certain steps that include: multiple annealing, multiple comminuting such as multiple ball milling, forming a non-magnetic phase on and/or in the powder particles at particle grain boundaries before particle consolidation such as pressing, and magnetic annealing of a pressed compact. A reproducible and high productive synthesis process is created by combining these steps with other steps, which makes possible production of mass quantities of MnBi powder and bulk magnets with high performance. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 16/974279 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1028 (20130101) B22F 2304/10 (20130101) Alloys C22C 22/00 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305564 | Manthiram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Arumugam Manthiram (Austin, Texas); Wangda Li (Austin, Texas); Steven Lee (Austin, Texas) |
| ABSTRACT | Described herein are low or no-cobalt materials useful as electrode active materials in a cathode for lithium or lithium-ion batteries. For example, compositions of matter are described herein, such as electrode active materials that can be incorporated into an electrode, such as a cathode. The disclosed electrode active materials exhibit high specific energy and voltage, and can also exhibit high rate capability and/or long operational lifetime. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213975 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/386 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305598 | HAMDAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PLUG POWER INC. (Latham, New York) |
| ASSIGNEE(S) | PLUG POWER INC. (Latham, New York) |
| INVENTOR(S) | Monjid HAMDAN (Worcester, Massachusetts); Cortney MITTELSTEADT (Wayland, Massachusetts); Matthew WEAVER (Cambridge, Massachusetts); Robert STONE (Danvers, Massachusetts) |
| ABSTRACT | Method and system for electrochemically compressing hydrogen. In one embodiment, the system includes a membrane electrode assembly (MEA) that includes a polymer electrolyte membrane (PEM), an anode, and a cathode. First and second gas diffusion media are positioned adjacent the cathode and anode, respectively. A humidifying membrane is positioned next to the second gas diffusion medium on a side opposite the anode. A water supply is connected to the humidifying membrane, and a hydrogen gas supply is connected to the second gas diffusion medium. A hydrogen gas collector including a back pressure regulator is connected to the first gas diffusion medium. Separators, positioned on opposite sides of the MEA, are connected to a power source. In use, hydrogen is electrochemically pumped across the MEA and collected in the hydrogen gas collector. The PEM is kept properly humidified by the humidifying membrane, which releases water into the second gas diffusion medium. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162654 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/248 (20130101) H01M 8/0273 (20130101) H01M 8/1004 (20130101) H01M 8/1044 (20130101) H01M 8/04149 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305628 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengcheng Zhang (Naperville, Illinois); Noah Mark Johnson (Westmont, Illinois) |
| ABSTRACT | An electrochemical device includes an electrolyte having a hydroxamate or N-hydroxyamide compound. |
| FILED | Tuesday, March 24, 2020 |
| APPL NO | 16/828748 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 259/10 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 2300/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305644 | Ernst et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy C. Ernst (Columbus, Indiana); Jonathan A. Dickson (Columbus, Indiana); Manik Narula (Columbus, Indiana) |
| ABSTRACT | A cooling system for an electrified vehicle includes a first cooling loop for circulating coolant for cooling at least one of power electronics and a motor/generator of the vehicle. The first coolant loop includes a heat exchanger for exchanging heat with the coolant in the first cooling loop. A second cooling loop is provided for circulating coolant for cooling a battery of the vehicle. The second cooling loop includes a coolant chiller connected to a refrigeration system of the vehicle for exchanging heat in the coolant received from the battery with the refrigeration system of the vehicle. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224523 |
| CURRENT CPC | Arrangements of Heating, Cooling, Ventilating or Other Air-treating Devices Specially Adapted for Passenger or Goods Spaces of Vehicles B60H 1/00278 (20130101) B60H 1/00392 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 58/26 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/66 (20150401) Original (OR) Class H01M 10/613 (20150401) H01M 10/625 (20150401) H01M 10/635 (20150401) H01M 10/6568 (20150401) H01M 2220/20 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20263 (20130101) H05K 7/20272 (20130101) H05K 7/20927 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210300600 | Moody |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tristan C. Moody (Houston, Texas) |
| ABSTRACT | Segmented shields are disclosed comprising material combinations and rolled configurations to impede and mitigate through-and-through penetration damage of a structure incorporating the segmented shields from the damage resulting from the impact of high-velocity micro-meteoroids and orbital debris particulate. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 16/829298 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210300601 | Moody |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tristan C. Moody (Houston, Texas) |
| ABSTRACT | Segmented shields are disclosed comprising material combinations and rolled configurations to impede and mitigate through-and-through penetration damage of a structure incorporating the segmented shields from the damage resulting from the impact of high-velocity micro-meteoroids and orbital debris particulate. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 16/829369 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302305 | Hosseini |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Seyedeh Sona Hosseini (Pasadena, California) |
| ABSTRACT | Ultra-miniature spatial heterodyne spectrometers (SHSs) are presented. Ultra-miniature SHSs in accordance with the invention, comprise a beam-splitter and gratings configured to generate a fringe pattern for spectroscopic detection. Many embodiments include input optics and a sensor and are configured in a way to omit collimating optics and imaging optics from the SHS. Compared to conventional SHSs known in the art, the present invention enables fewer parts, significantly smaller and lighter SHSs, are more efficient and robust, and require less maintenance. Many embodiments are field-deployable, in that such embodiments can be deployed for hand held use in real-world or remote activities outside of research or diagnostic facilities. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/218130 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/255 (20130101) Original (OR) Class G01N 33/18 (20130101) G01N 33/24 (20130101) G01N 33/49 (20130101) G01N 33/4833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302380 | Haldren et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES OF AMERICAS AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold A. Haldren (Silver Spring, Maryland); Daniel F. Perey (Yorktown, Virginia); William T. Yost (Suffolk, Virginia); K. Elliott Cramer (Yorktown, Virginia); Mool C. Gupta (Keswick, Virginia) |
| ABSTRACT | A method and system for ultrasonic testing of adhesion within a sample, which provides ultrasonic bursts of different frequencies to the sample and maintains a predetermined phase difference between echoes returned from the sample and representative reference signals of the bursts supplied to the sample until a spectrum of the phase differences versus frequency is obtained and from which properties of the adhesion at an interface reflecting the echoes are derivable. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209934 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/12 (20130101) Original (OR) Class G01N 29/44 (20130101) G01N 2291/014 (20130101) G01N 2291/044 (20130101) G01N 2291/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210305577 | Gallant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachuetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Betar Gallant (Cambridge, Massachusetts); Aaron Melemed (Cambridge, Massachusetts) |
| ABSTRACT | Articles and methods related to passivation materials on alkaline earth metals are generally described. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/163036 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/381 (20130101) H01M 4/628 (20130101) Original (OR) Class H01M 10/054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306071 | VELAZCO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose E. VELAZCO (Pasadena, California) |
| ABSTRACT | Optical ground terminals (OGT) allowing high optical rate communications for line of sight and non-line of sight operating conditions are disclosed. The described devices include a multifaceted structure where optical telescopes, phase array antennas, and arrays of optical detectors are disposed. Methods to calculate angle-of-arrival based the contributions from optical detectors are also disclosed. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184446 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/48 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0816 (20130101) G02B 27/30 (20130101) Antennas, i.e Radio Aerials H01Q 3/2676 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/042 (20130101) Transmission H04B 10/25 (20130101) H04B 10/50 (20130101) H04B 10/118 (20130101) Original (OR) Class H04B 10/616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20210298946 | Brockman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brockman-Hastings LLC (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Britt Brockman (Louisville, Kentucky); Jeffrey Todd Hastings (Lexington, Kentucky); Carlos Andres Jarro (Lexington, Kentucky); James L. Russell (Lexington, Kentucky) |
| ABSTRACT | An eye implantation device has a body including a support system adapted to engage at three points with an iridocorneal angle of an anterior chamber of an eye into which the device is implanted. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139205 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/02 (20130101) A61B 3/16 (20130101) A61B 5/6882 (20130101) A61B 5/14503 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210298947 | Brockman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brockman-Hastings LLC (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Britt Brockman (Louisville, Kentucky); Jeffrey Todd Hastings (Lexington, Kentucky); Carlos Andres Jarro (Lexington, Kentucky); James L. Russell (Lexington, Kentucky) |
| ABSTRACT | A method of implanting includes steps of making a corneal incision of the eye, inserting the eye implantation device into the eye through the corneal incision and securing the eye implantation device by engaging the eye implantation device at three points with the iridocorneal angle of the anterior chamber of the eye into which the device is implanted. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141623 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/16 (20130101) A61B 5/6882 (20130101) A61B 5/14546 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0017 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210299281 | Yuan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baohong Yuan (Arlington, Texas) |
| ABSTRACT | A method of imaging cancer stem cells comprises disposing a population of first ultrasound-switchable fluorophorms having a first switching threshold in the biological environment, the first ultrasound-switchable fluorophores being functionalized for attachment to a first biomarker expressed by the CSCs; disposing a population of second ultrasound-switchable fluorophorms having a second switching threshold in the biological environment, the second ultrasound-switchable fluorophores being functionalized for attachment to a second biomarker expressed by the CSCs; exposing the biological environment to an ultrasound beam to form an activation region; disposing one or more of the first and/or second ultrasound-switchable fluorophores in the activation region to switch the first and/or second fluorophores from an off state to an on state; exciting the first and second ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation; and detecting light emitted by the first and second ultrasound-switchable fluorophores. |
| FILED | Wednesday, July 17, 2019 |
| APPL NO | 17/260759 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0097 (20130101) A61B 5/489 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) Original (OR) Class A61K 49/0091 (20130101) A61K 49/0093 (20130101) A61K 49/222 (20130101) A61K 49/223 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/542 (20130101) G01N 33/582 (20130101) G01N 33/57492 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302751 | Brockman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brockman-Hastings LLC (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Britt Brockman (Louisville, Kentucky); Jeffrey Todd Hastings (Lexington, Kentucky); Carlos Andres Jarro (Lexington, Kentucky); James L. Russell (Lexington, Kentucky) |
| ABSTRACT | A reversible earpiece for a head-mounted device includes (a) a first body section, (b) a second body section, (c) a cooperating pivot and a receiver and (d) a cooperating locking ball and a guide track. The receiver is adapted to receive and hold the pivot. The guide track is adapted to receive and hold the locking ball. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154355 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0176 (20130101) Original (OR) Class G02B 2027/0178 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 5/20 (20130101) G02C 5/143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210300876 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rhia M Martin (Arvada, Colorado); Douglas L. Gin (Longmont, Colorado); Richard D Noble (Boulder, Colorado); Vinh The Nguyen (Arvada, Colorado); Brian J Elliott (Superior, Colorado) |
| ABSTRACT | A polymerizable Gemini surfactant based on tail groups with mixed isomer dienes. The Gemini surfactants may be produced having imidazolium head groups and diene tail groups with a near-equal abundance of the “E” and “Z” isomers. These compounds are lyotropic liquid crystals that can form bicontinuous cubic phases by self-assembly. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259467 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/58 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/52 (20130101) C09K 2019/528 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301108 | Sinclair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Taproot Medical Technologies, LLC (Seattle, Washington) |
| ASSIGNEE(S) | Taproot Medical Technologies, LLC (Seattle, Washington) |
| INVENTOR(S) | Andrew William Sinclair (Seattle, Washington); Timothy James Fujihara (Seattle, Washington) |
| ABSTRACT | Disclosed are hydrogel compositions comprising both polysaccharide-based and polyzwitterionic components, methods of making the compositions, and methods of using the compositions for various clinical and biomedical applications. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/042 (20130101) A61K 8/735 (20130101) A61K 9/06 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/52 (20130101) A61L 2430/34 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2305/08 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210306075 | MORTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morton Photonics (West Friendship, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul A. MORTON (West Friendship, Maryland); Jacob KHURGIN (Pikesville, Maryland) |
| ABSTRACT | High-performance ultra-wideband Phased Array Antennas (PAA) are disclosed, having unique capabilities, enabled through photonic integrated circuits and novel optical architectures. Unique capabilities for PAA systems are enabled by photonic integration and ultra-low-loss waveguides. Novel aspects include optical multiplexing combining wavelength division multiplexing and/or a novel extension to array photodetectors, providing the capability to combine many RF photonic signals with very low loss. Architectures include tunable optical up-conversion and down-conversion systems, moving a chosen frequency band between baseband and a high RF frequency band with high dynamic range. Simultaneous multi-channel RF beamforming is achieved through power combining/splitting of optical signals. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224580 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/00 (20130101) Antennas, i.e Radio Aerials H01Q 3/2676 (20130101) Transmission H04B 10/40 (20130101) H04B 10/25759 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210298276 | Lauth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Center for Aquaculture Technologies, Inc. (San Diego, California) |
| ASSIGNEE(S) | Center for Aquaculture Technologies, Inc. (San Diego, California) |
| INVENTOR(S) | Xavier Christophe Lauth (San Diego, California); John Terrell Buschanan (San Diego, California) |
| ABSTRACT | The disclosure provides a method of generating a sterile sex-determined fish, crustacean, or mollusk. The method comprises breeding (i) a fertile homozygous mutated female fish, crustacean, or mollusk having at least a first mutation and a second mutation with (ii) a fertile homozygous mutated male fish, crustacean, or mollusk having at least the first mutation and the second mutation to produce the sterile sex-determined fish, crustacean, or mollusk. The first mutation disrupts one or more genes that specify sexual differentiation, the second mutation disrupts one or more genes that specify gamete function, and the fertility of the fertile homozygous female fish, crustacean, or mollusk and the fertile homozygous mutated male fish, crustacean, or mollusk has been rescued. The disclosure also provides methods of making broodstock for use in producing sterile sex-determined fish, crustacean, or mollusks, as well as the broodstock itself. |
| FILED | Monday, August 12, 2019 |
| APPL NO | 17/264029 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Original (OR) Class A01K 67/033 (20130101) A01K 2227/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210302287 | Zheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siyang Zheng (State College, Pennsylvania); Mauricio Terrones (State College, Pennsylvania); Yin-Ting Yeh (State College, Pennsylvania); Yi Tang (State College, Pennsylvania); Huaguang Lu (State College, Pennsylvania); Nestor Perea Lopez (State College, Pennsylvania); Yiqiu Xia (State College, Pennsylvania) |
| ABSTRACT | The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236814 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class G01N 1/4077 (20130101) G01N 33/552 (20130101) G01N 33/54346 (20130101) G01N 33/56983 (20130101) G01N 2001/4088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210299388 | VANKOEVERING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle VANKOEVERING (Columbus, Ohio); Owen TIEN (Ann Arbor, Michigan); Glenn E GREEN (Gregory, Michigan); David A. ZOPF (Ann Arbor, Michigan) |
| ABSTRACT | A system for providing mechanical ventilation to a plurality of patients using a single ventilator is provided. The system includes a first branched adapter may be coupled to a ventilator, the first branched adapter having a plurality of branches and configured to divide a ventilator gas stream into a plurality of gas streams for delivery to a respective plurality of patients. The system includes a pressure regulator in fluid communication with one branch of the first branched adapter and with one patient, the pressure regulator being configured to reduce the pressure of the gas stream reaching the patient such that it is less pressurized than the ventilator gas stream. The system includes a second branched adapter may be coupled to a ventilator, the second branched adapter having a plurality of branches and configured to unite expired gas streams from the plurality of patients into a single expiratory gas stream. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219248 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) A61M 16/0057 (20130101) A61M 16/208 (20130101) A61M 16/0816 (20130101) Original (OR) Class A61M 16/0875 (20130101) A61M 2205/3331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210301277 | FAGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ammon FAGER (Durham, North Carolina); Maureane HOFFMAN (Durham, North Carolina) |
| ABSTRACT | Provided are chimeric Protein C-Factor VII proteins comprising a Gla domain from Protein C (PC), an EGF-1 domain from PC, an EGF-2 domain from Factor VII (FVII), and a protease domain from FVII. |
| FILED | Saturday, August 03, 2019 |
| APPL NO | 17/265277 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/00 (20130101) C07K 2319/01 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6437 (20130101) Original (OR) Class C12N 9/6464 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
| US 20210300598 | Beck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rocket Lab USA, Inc. (Huntington Beach, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Beck (Auckland, New Zealand); Peter Barlow (Huntington Beach, California); David Yoon (La Crescenta, California); Ben Malcolm (Auckland, New Zealand) |
| ABSTRACT | A satellite dispenser and method of using same are disclosed. In various embodiments, a satellite dispenser as disclosed herein includes a dispenser body defining an interior cavity to accommodate a payload; and a plurality of externally adjustable restraints positioned within the interior cavity and configured to be extended further into the interior cavity by actuation of a manual interface external to the interior cavity. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343614 |
| CURRENT CPC | Cutting; Details Common to Machines for Perforating, Punching, Cutting-out, Stamping-out or Severing B26D 5/12 (20130101) Vehicles Adapted for Load Transportation or to Transport, to Carry, or to Comprise Special Loads or Objects B60P 7/16 (20130101) B60P 7/135 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/22 (20130101) Original (OR) Class B64G 1/645 (20130101) Hinges or Suspension Devices for Doors, Windows or Wings E05D 3/08 (20130101) E05D 7/00 (20130101) Devices for Moving Wings into Open or Closed Position; Checks for Wings; Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05F 1/105 (20130101) E05F 3/20 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 29/005 (20130101) F16C 33/24 (20130101) F16C 2326/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210302300 | Cooksey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Alan Cooksey (Gaithersburg, Maryland); Paul Nathan Patrone (Washington Grove, Maryland); Anthony Jose Kearsley (Hanover, Maryland) |
| ABSTRACT | Embodiments of the present invention described herein provide a device that can measure a single particle in flow several times along a microchannel with integrated waveguides that carry optical signals (e.g. excitation, emission, transmission, and scattered light) to and from measurement regions. Embodiments of the present invention used to perform multiple measurements of particles, such as microspheres or cells, traveling in a sample fluid through a microfluidic channel achieve lower uncertainties, discriminate complex samples, and account for sources of uncertainty that might be related to the shape, deformability, stability, or activity of objects in a liquid sample. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345691 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) Original (OR) Class G01N 15/1436 (20130101) G01N 15/1484 (20130101) G01N 2015/1413 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20210302020 | Graham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen Graham (Niskayuna, New York); Kwanwoo Kim (Montgomery, Ohio); Nicholas Magina (Niskayuna, New York); Sharath Nagaraja (Niskayuna, New York); Fei Han (Niskayuna, New York) |
| ABSTRACT | The systems and methods described herein relate to a dome of a gas turbine assembly configured to suppress pressure pulsations. The systems and methods provide a dome having an aperture configured to surround an injector assembly of a combustor. The dome having a front panel extending radially from the aperture. The systems and methods couple a first cavity to the front panel. The first cavity includes a series of ducts. A first duct of the series of ducts is configured to receive airflow into the first cavity from a compressor and a second set of ducts of the series of ducts and a third duct of the series of ducts are configured to direct airflow to the combustor from the first cavity, wherein the third duct has a larger diameter than the second set of ducts. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138048 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/35 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/04 (20130101) F23R 3/10 (20130101) F23R 3/26 (20130101) Original (OR) Class F23R 3/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210305315 | Solgun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Firat Solgun (Ossining, New York); Dongbing Shao (Briarcliff Manor, New York); Markus Brink (White Plains, New York) |
| ABSTRACT | A system includes a first quantum circuit plane that includes a first qubit, a second qubit and a third qubit. A coupled-line bus is coupled between the first qubit and the second qubit. A second circuit plane is connected to the first quantum circuit plane, comprising a control line coupled to the third qubit. The control line and the coupled-line bus are on different planes and crossing over each other, and configured to mitigate cross-talk caused by the crossing during signal transmission. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 16/833479 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210304116 | Dearing |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia) |
| ABSTRACT | Systems and methods for shipping items using codes existing on packaging of items is described. Systems and methods do not require a shipping label or additional codes to be placed on an item, thus eliminating the box-in-a-box situation that frequently occurs. The systems use the existing codes, such as UPC, SKU, serial numbers, etc., and utilize order information and distribution network information to move and track items through the distribution network to delivery. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212942 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 30, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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