FedInvent™ Patent Applications
Application Details for Thursday, February 24, 2022
This page was updated on Friday, February 25, 2022 at 04:11 PM GMT
Department of Health and Human Services (HHS)
| US 20220054001 | Zhu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Quing Zhu (St. Louis, Missouri); Shihab Uddin (St. Louis, Missouri); William Chapman (St. Louis, Missouri); Xiandong Leng (St. Louis, Missouri); Matthew Mutch (St. Louis, Missouri) |
| ABSTRACT | A system for determining a probability of normal rectal tissue composition within a region of interest of an ultrasound or photoacoustic image of the rectal tissue is disclosed. The system includes a computing device with at least one processor configured to receive at least one of a photoacoustic image and an ultrasound image; select a region of interest within the at least one of a photoacoustic image and an ultrasound image; transform the region of interest into the probability of normal rectal tissue composition using a CNN model; and display the probability of normal rectal tissue composition to an operator of the system. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408371 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/31 (20130101) Original (OR) Class A61B 5/0004 (20130101) A61B 5/742 (20130101) A61B 5/7275 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Image Data Processing or Generation, in General G06T 7/37 (20170101) G06T 2207/10132 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054012 | Hillman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth Marjorie Clare Hillman (New York, New York); Sean A. BURGESS (New York, New York) |
| ABSTRACT | Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM). |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462824 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0064 (20130101) Original (OR) Class A61B 5/0066 (20130101) A61B 5/0071 (20130101) A61B 5/0073 (20130101) A61B 5/0075 (20130101) A61B 5/0088 (20130101) A61B 5/444 (20130101) A61B 5/445 (20130101) A61B 2562/0238 (20130101) A61B 2562/0242 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) G01J 3/457 (20130101) G01J 3/2889 (20130101) Optical Elements, Systems, or Apparatus G02B 23/2476 (20130101) G02B 26/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054013 | Tearney et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
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| INVENTOR(S) | Guillermo J. Tearney (Cambridge, Massachusetts); Jiheun Ryu (Cambridge, Massachusetts) |
| ABSTRACT | A method of correcting distortion of an image, including: analyzing, by a processor, an image segment of the image to identify a speckle artifact, the image segment being obtained from a scanning imaging device; determining, by the processor, an aspect ratio of a shape of the speckle artifact; determining, by the processor, a correction factor for the shape of the speckle artifact based on the aspect ratio; and adjusting, by the processor, a dimension of the image segment based on the correction factor. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 17/310263 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Original (OR) Class A61B 5/7207 (20130101) A61B 5/7275 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4788 (20130101) G01N 2021/479 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054109 | Bhuyan et al. |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
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| INVENTOR(S) | Anshuman Bhuyan (Milpitas, California); Jung Woo Choe (Sunnyvale, California); Amin Nikoozadeh (Palo Alto, California); Butrus T. Khuri-Yakub (Palo Alto, California) |
| ABSTRACT | Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410364 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) Original (OR) Class A61B 8/4483 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) A61N 7/02 (20130101) A61N 2007/0021 (20130101) A61N 2007/0052 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0292 (20130101) B06B 2201/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054318 | Schwenk et al. |
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| APPLICANT(S) | Giner Life Sciences, Inc. (Newton, Massachusetts) |
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| INVENTOR(S) | Melissa N. Schwenk (Somerville, Massachusetts); Ernesto Victor Ruiz (Wharton, New Jersey); Simon G. Stone (Arlington, Massachusetts); Linda A. Tempelman (Lincoln, Massachusetts) |
| ABSTRACT | System and method for modification of fluid environment of an ear. In one embodiment, the system includes an earpiece mountable within an ear canal. The earpiece includes a fluid delivery path for fluid to be delivered to the ear and a fluid removal path for fluid to be removed from the ear. The system also includes an electronics housing. The electronics housing may be directly mounted on the earpiece or positioned outside the ear. The system further includes an electrochemical gas generating device positioned within the electronics housing. In use, oxygen or the like is generated by the electrochemical gas generating device and is conveyed through the fluid delivery path of the earpiece, emerging from the earpiece distal end. The gas released from the earpiece causes fluid in the ear to be swept into the fluid removal path of the earpiece and eventually expelled to the outside of the ear. |
| FILED | Saturday, August 21, 2021 |
| APPL NO | 17/408396 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 11/006 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 13/003 (20130101) A61M 31/00 (20130101) A61M 2202/0208 (20130101) A61M 2205/502 (20130101) A61M 2205/8206 (20130101) A61M 2210/0662 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054364 | STEWART et al. |
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| APPLICANT(S) | MESOSIL INC. (TORONTO, Canada) |
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| INVENTOR(S) | Cameron Alexander STEWART (Springwater, Canada); Benjamin David HATTON (Toronto, Canada); Yoav FINER (Toronto, Canada) |
| ABSTRACT | A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/464211 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/08 (20130101) A01N 43/40 (20130101) A01N 47/44 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 6/20 (20200101) A61K 6/35 (20200101) A61K 6/40 (20200101) A61K 6/54 (20200101) A61K 6/71 (20200101) A61K 6/74 (20200101) A61K 6/76 (20200101) A61K 6/80 (20200101) A61K 6/84 (20200101) Original (OR) Class A61K 6/86 (20200101) A61K 6/802 (20200101) A61K 6/849 (20200101) A61K 6/853 (20200101) A61K 6/864 (20200101) A61K 6/871 (20200101) A61K 9/0024 (20130101) A61K 9/0063 (20130101) A61K 9/143 (20130101) A61K 9/5115 (20130101) A61K 31/20 (20130101) A61K 31/155 (20130101) A61K 31/444 (20130101) A61K 31/785 (20130101) A61K 31/4425 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/10 (20130101) A61L 27/12 (20130101) A61L 27/025 (20130101) A61L 27/32 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/105 (20130101) A61L 27/306 (20130101) A61L 27/425 (20130101) A61L 27/427 (20130101) A61L 27/446 (20130101) A61L 2300/206 (20130101) A61L 2300/208 (20130101) A61L 2300/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 31/02 (20180101) A61P 31/04 (20180101) Acyclic or Carbocyclic Compounds C07C 279/14 (20130101) C07C 279/26 (20130101) Heterocyclic Compounds C07D 213/20 (20130101) C07D 213/74 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 3/32 (20130101) C08K 2003/325 (20130101) C08K 2003/2227 (20130101) C08K 2003/2237 (20130101) C08K 2003/2296 (20130101) Compositions of Macromolecular Compounds C08L 33/12 (20130101) C08L 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054416 | FOX et al. |
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| FUNDED BY |
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| APPLICANT(S) | Infectious Disease Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. FOX (Seattle, Washington); Amit Praful KHANDHAR (Issaquah, Washington); Neal VAN HOEVEN (Seattle, Washington); Jesse H. ERASMUS (Port Orchard, Washington); Susan S. LIN (Kirkland, Washington) |
| ABSTRACT | Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054419 | Graham et al. |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Barney S. Graham (Rockville, Maryland); Masaru Kanekiyo (Chevy Chase, Maryland); Hadi M. Yassine (Boyds, Maryland) |
| ABSTRACT | Novel, nanoparticle-based vaccines are provided that elicit an immune response to a broad range of infectious agents, such as influenza viruses. The nanoparticles comprise a heterogeneous population of fusion proteins, each comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to one or more immunogenic portions of a protein from an infectious agent, such as influenza virus. The fusion proteins self-assemble to form nanoparticles that display a heterogeneous population of immunogenic portions on their surface. When administered to an individual, such nanoparticles elicit an immune response to different strains, types, subtypes and species with in the same taxonomic family. Thus, such nanoparticles can be used to vaccinate an individual against infection by different Types, subtypes and/or strains of infectious agents. Also provided are specific fusion proteins, nucleic acid molecules encoding such fusion proteins and methods of using nanoparticles of the invention to vaccinate individuals. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519142 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/167 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 2039/6068 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054423 | Dahlman et al. |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
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| INVENTOR(S) | James Dahlman (Atlanta, Georgia); Kalina Paunovska (Atlanta, Georgia) |
| ABSTRACT | Lipid nanoparticles and compositions thereof are disclosed herein. An exemplary nanoparticle composition includes an ionizable lipid, a phospholipid, a PEG-lipid, and a cholesterol modified with a hydroxyl group near the D-sterol ring. The disclosed nanoparticle compositions can target liver Kupffer cells and endothelial cells more preferentially than hepatocytes which should be beneficial in treating liver diseases in which dysfunctional Kupffer cells and endothelial cells are involved in disease pathogenesis. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465034 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5146 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054462 | Knox et al. |
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| APPLICANT(S) | Eben ALSBERG (Chicago, Illinois); Oju JEON (Broadview Heights, Ohio); The Regents of the University of California (Oakland, California); Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Knox (San Francisco, California); Chelsea S. Bahney (Edwards, Colorado); Eben Alsberg (Chicago, Illinois); Oju Jeon (Broadview Heights, Ohio) |
| ABSTRACT | A method is provided for promoting salivary gland regeneration in a subject in need thereof comprising administering to acinar progenitor cells of the salivary gland at least one of a cholinergic agonist or muscarinic agonist to promote acinar cell generation. In particular, formulations comprising a muscarinic agonist such as cevimeline encapsulated in an alginate hydrogel can be formulated for local administration to a salivary gland and used in treatment of xerostomia. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/312196 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/006 (20130101) A61K 9/06 (20130101) A61K 31/27 (20130101) A61K 31/439 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 47/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054479 | JENKINS |
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| APPLICANT(S) | Elysium Therapeutics, Inc. (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. JENKINS (Half Moon Bay, California) |
| ABSTRACT | The invention provides pharmaceutical compositions comprising macromolecular gastrointestinal enzyme-labile opioid prodrugs, co-formulated with small-molecule and/or macromolecular gastrointestinal enzyme inhibitors. The macromolecular constructs are minimally absorbed from the GI tract, and can produce non-linear pharmacokinetic profiles of the delivered opioid agonist following oral ingestion. An optional macromolecular opioid antagonist may also be present in compositions of the invention to discourage tampering by potential abusers. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/475224 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/55 (20170801) A61K 47/61 (20170801) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054489 | Meyerowitz et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Justin Gabriel Meyerowitz (San Francisco, California); William Clay Gustafson (San Francisco, California); William A. Weiss (San Francisco, California); Nicholas T. Hertz (San Francisco, California); Kevan M. Shokat (San Francisco, California) |
| ABSTRACT | Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461616 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class Heterocyclic Compounds C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054494 | Jackson et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Vanderbilt University (Nashville, Tennessee); The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Vanderbilt University (Nashville, Tennessee); The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Edwin Kerry Jackson (Pittsburgh, Pennsylvania); Lori Ann Birder (Pittsburgh, Pennsylvania); Amanda Sue Wolf-Johnston (Pittsburgh, Pennsylvania); Roger Dmochowski (Nashville, Tennessee); Alan J. Wein (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods of treating bladder or urethra dysfunction or disease in a subject and methods of increasing bladder smooth muscle contractility or increasing bladder wall volume in a subject are disclosed. In some examples, a purine nucleoside phosphorylase (PNPase) inhibitor or purine nucleoside substrate is administered, such as 8-aminoguanine or forodesine. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/434894 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 31/522 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054499 | Rubin et al. |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lee L. Rubin (Wellesley, Massachusetts); Amy J. Wagers (Cambridge, Massachusetts); Amanda K. W. Gee (Alexandria, Virginia); Feodor D. Price (Somerville, Massachusetts) |
| ABSTRACT | The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/341343 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/403 (20130101) A61K 31/496 (20130101) A61K 31/553 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054500 | Bellacosa et al. |
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| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania); Institut Curie (Paris, France); Institut de Genetique et de Biologie Moleculaire et Cellulaire (Illkrich, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfonso Bellacosa (Philadelphia, Pennsylvania); Rossella Tricarico (Philadelphia, Pennsylvania); Tim Yen (Philadelphia, Pennsylvania); Vikram Bhattacharjee (Philadelphia, Pennsylvania); Pietro Mancuso (Philadelphia, Pennsylvania); Lionel Larue (Paris, France); Irwin Davidson (Ilkrich, France) |
| ABSTRACT | The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/277 (20130101) A61K 31/353 (20130101) A61K 31/404 (20130101) A61K 31/473 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/546 (20130101) A61K 31/609 (20130101) A61K 31/5575 (20130101) Original (OR) Class A61K 33/24 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054505 | Ren |
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| FUNDED BY |
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| APPLICANT(S) | Virginia Commonwealth University (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shunlin Ren (Richmond, Virginia) |
| ABSTRACT | Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383059 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Original (OR) Class A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054513 | HAMRICK et al. |
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| FUNDED BY |
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| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jodie HAMRICK (New Holland, Pennsylvania); Christopher J. BURNS (Malvern, Pennsylvania); Daniel C. PEVEAR (Downingtown, Pennsylvania); Luigi XERRI (Wayne, Pennsylvania); Timothy HENKEL (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland) |
| ABSTRACT | Described herein are combination compositions comprising a beta-lactamase inhibitor. In certain embodiments, the combination compositions described herein are useful in the treatment of bacterial infections. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/275405 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/546 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054546 | ZHOU |
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| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang ZHOU (Martinez, Georgia) |
| ABSTRACT | Disclosed herein are engineered polyfunctional CD4+ T cells/CAR T cells and methods of their use for the treatment of cancers. One embodiment provides a method of producing polyfunctional CD4+ T cells by constitutively activating STAT5A in the cells to induce a polyfunctional phenotype. Also provided is a method of reversing exhaustion in tumor-specific CD4+ T cells by engineering the cells to express Fos, Jun, Nr4a1, or combinations thereof but not express Tox, Pdcd1, Ctla4, Haver2, Lag3, Tigit, Slam6, Nrf4a2, and administering the engineered cells to a subject. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395184 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054547 | DITTEL |
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| FUNDED BY |
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| APPLICANT(S) | VERSITI BLOOD RESEARCH INSTITUTE FOUNDATION, INC. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BONNIE N. DITTEL (Milwaukee, Wisconsin) |
| ABSTRACT | GITRL+ IgDlow/− B cells as well as methods of making and using said cells are described herein. Also described are methods for treating an autoimmune disease or an inflammatory condition in a subject in need there of using said B cells. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/413456 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054549 | Wagner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital (dba Seattle Children's Research Institute) (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thor Wagner (Seattle, Washington); Jaya Sahni (Seattle, Washington) |
| ABSTRACT | Some aspects of the methods and compositions provided herein relate to the disruption of at least one CD4 gene in a cell, such as a CD4+ T cell. In some embodiments, the disruption comprises use of a CRISPR guide polynucleotide. Some embodiments also include the preparation and use of a cell having at least one disrupted CD4 gene and a chimeric antigen receptor (CAR). Some aspects of the methods and compositions provided herein relate to CARs, such as an anti-CD4 CAR or an anti-CD19 CAR, and use to treat disorders including HIV, acute myeloid leukemia (AML), and acute lymphocytic leukemia (ALL). |
| FILED | Tuesday, March 17, 2020 |
| APPL NO | 17/435535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/70514 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054554 | PROCKOP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darwin J. PROCKOP (Philadelphia, Pennsylvania); Dong-ki KIM (College Station, Texas); Hidetaka NISHIDA (College Station, Texas); Askok K. SHETTY (Austin, Texas) |
| ABSTRACT | Preparations comprising an enriched population of extracellular vesicles (nEVs) having a negatively charged surface, and that are CD81+ and CD9−, are provided. Improved processes and methods for producing an enriched population of nEVs from non-murine cells, especially human origin cells and/or tissues, are disclosed. Therapeutic methods for using the preparations, including for reducing brain inflammation and treatment of various pathologies associated with brain inflammation, such as by intravenous or intranasal administration, are also described. Methods and preparations for reducing brain inflammation associated with traumatic brain injury (TBI) are also disclosed. A method for treating a patient having suffered a mild traumatic injury (mTMI), or concussion, such as a sports-related head injury, is also disclosed. The nEVs are also demonstrated to reduce the expression level of IL-Iβ in brain tissue of an animal having had traumatic brain injury. Methods for improving cognitive function and performance in animals after a traumatic brain injury is also demonstrated using the preparations of nEVs disclosed herein. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354801 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/12 (20130101) A61K 35/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 43/00 (20180101) Peptides C07K 5/06034 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) C12N 2500/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054561 | Ting et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jenny P.-Y. Ting (Chapel Hill, North Carolina); Hao Guo (Hillsborough, North Carolina); Liang Chen (Worcester, Massachusetts); Jason W. Tam (Chapel Hill, North Carolina); Vincent B. Young (Ann Arbor, Michigan); Mark Koenigsknecht (Cary, North Carolina) |
| ABSTRACT | Disclosed herein are data indicating that specific gut commensal bacteria, and metabolites thereof, can mitigate the outcome of high dose total body irradiation. Based on this, provided herein are methods of mitigating and/or preventing side effects from radiation therapy using short chain fatty acid producing bacterium or metabolites thereof. Cancer and tumor treatments and adjuvant therapies are also provided. Methods of treating and/or mitigating damage to a hematopoietic and/or gastrointestinal system in a subject are also provided using the disclosed adjuvant therapeutic compositions. |
| FILED | Monday, December 16, 2019 |
| APPL NO | 17/413861 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054564 | MILES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linde MILES (New York, New York); John POIRIER (New York, New York); Charles RUDIN (New York, New York) |
| ABSTRACT | A method for selecting cancer patient for treatment with Seneca Valley Virus (SVV) by determining expression of ANTXR1 in a cancerous tissue in a cancer patient; and designating the cancer patient as a candidate for treatment with SVV if normal levels or elevated levels of ANTXR1 expression is detected in the cancerous tissue. Also a method for treating a cancer patient with SVV is disclosed. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32033 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054589 | Urish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Urish (Sewickley, Pennsylvania); Jonathan Brendan Mandell (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of treating or preventing a microbial infection in a patient is provided, along with a wound irrigation system and a composition in the form of an irrigation liquid for reducing microbial load or preventing microbial infection in a wound. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/546 (20130101) A61K 38/10 (20130101) A61K 38/1729 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054591 | Garrett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Garrett (Brookline, Massachusetts); Michael Howitt (Jamaica Plain, Massachusetts) |
| ABSTRACT | Described herein are methods for the induction of a TH2 immune response and for the treatment and/or prevention of diseases associated with pathological immune responses and parasitic infection. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390176 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 38/20 (20130101) Original (OR) Class A61K 39/02 (20130101) A61K 39/39 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 33/00 (20180101) Peptides C07K 14/473 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054607 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Ka Wang WANG (Gainesville, Florida); Zhihui YANG (Gainesville, Florida); Tian ZHU (Gainesville, Florida) |
| ABSTRACT | Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Active immunization with GFAP protein or GFAP peptide or passive immunization with anti-GFAP antibodies or treatment with a GFAP-binding aptamer can be used to reduce the post-TBI induced expression of GFAP, Tau and p-Tau in brain cortex tissues to attenuate the increased serum levels of GFAP after brain injury, and reduce the serum levels of pNF-H, Tau and p-Tau TBI. In addition, GFAP immunization can alleviate anxiety behavior and improve cognitive performance post-injury. Thus, active or passive GFAP immunization or administration of GFAP-binding aptamer(s) provides a treatment with therapeutic value in suppressing astroglial activation/astrogliosis, and in treating neural injuries such as traumatic brain injury, stroke, spinal cord injury, cerebral hemorrhage, or neurodegenerative diseases such as chronic traumatic encephalopathy, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, and other dementias. |
| FILED | Friday, December 13, 2019 |
| APPL NO | 17/413835 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 39/0007 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054608 | SCOTT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. SCOTT (Bethesda, Maryland); Yongchan KIM (Rockville, Maryland); Aihong ZHANG (Ellicott City, Maryland) |
| ABSTRACT | Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or bi-specific antibodies. The agents and methods can be used to reduce undesirable immune responses. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 21/04 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0638 (20130101) C12N 2502/1107 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054610 | Deleyrolle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loic Pierre Deleyrolle (Gainesville, Florida); Elias Sayour (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides compositions comprising a liposome comprising a cationic lipid and nucleic acid molecules comprising a sequence of a nucleic acid molecule expressed by slow-cycling cells (SCCs). The present disclosure also provides methods of preparing an anti-tumor liposome composition. In exemplary embodiments, the method comprises (a) isolating SCCs from a mixed tumor cell population in accordance with any one of the presently disclosed in vitro method of isolating SCCs from a mixed tumor cell population, (b) extracting nucleic acid molecules from the isolated SCCs, and (c) mixing the nucleic acid molecules with a cationic lipid to make an anti-tumor liposome composition. The method of preparing an anti-tumor liposome composition in alternative embodiments comprises mixing at least one SCC transcriptome nucleic acid molecule as described herein with a cationic lipid to make an anti-tumor liposome composition. Tumor treatment methods are furthermore provided by the present disclosure. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/275399 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/80 (20180801) A61K 2039/55555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054617 | David et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); KANPRO RESEARCH, INC. (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil A. David (Minneapolis, Minnesota); Michael J.H. Brush (Minneapolis, Minnesota); Fei Philip Gao (Lawrence, Kansas) |
| ABSTRACT | This disclosure describes a subunit vaccine for a flavivirus, methods of making the vaccine, and methods of using the vaccine. The flavivirus may include, is a mosquito-borne flavivirus, for example, Zika virus (ZIKV), dengue virus (DENV), Yellow Fever (YF) virus, and West Nile Virus (WNV). The subunit vaccine may be administered with an adjuvant. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/312534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/55511 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054630 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian G. Pierce (College Park, Maryland); Thomas R. Fuerst (College Park, Maryland); Roy A. Mariuzza (College Park, Maryland); Steven K.H. Foung (College Park, Maryland); Zhen-Yong Keck (College Park, Maryland) |
| ABSTRACT | Disclosed are modified HCV E2 glycoproteins. Disclosed are modified HCV E2 glycoproteins comprising an antigenic domain D, wherein the modified HCV E2 glycoproteins comprise one or more amino acid alterations in the antigenic domain D, wherein at least one amino acid alteration is a proline substitution. In some aspects, the proline substitution occurs at position 445 based on the amino acid numbering of HCV strain H77. Disclosed are modified HCV E2 glycoproteins comprising an antigenic domain A, wherein the antigenic domain A comprises an N-glycan sequon substitution. In some aspects, the N-glycan sequon substitution results in an Asn-Xaa-Ser or Asn-Xaa-Thr substitution, wherein Xaa is any amino acid except proline. Also disclosed are methods of using the disclosed modified HCV E2 glycoproteins, such as methods of inducing an immune response in a subject, methods of treating a subject, and methods of increasing antigenicity of HCV E2 glycoprotein. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405884 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/29 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/1833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220054639 — In-situ stable injectable collagen-based hydrogels for cell and growth factor delivery
| US 20220054639 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yunzhi Yang (Stanford, California); Seyedsina Moeinzadeh (Mountain View, California) |
| ABSTRACT | A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 47/02 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054642 | Webber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew J. Webber (Cambridge, Massachusetts); Eric Andrew Appel (Palo Alto, California); Robert S. Langer (Newton, Massachusetts); Daniel Griffith Anderson (Framingham, Massachusetts) |
| ABSTRACT | The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/26 (20130101) A61K 38/28 (20130101) A61K 47/34 (20130101) A61K 47/60 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/6889 (20170801) Heterocyclic Compounds C07D 519/00 (20130101) Peptides C07K 14/62 (20130101) C07K 14/605 (20130101) C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054659 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Wojciech G. Lesniak (Baltimore, Maryland); Srikanth Boinapally (Baltimore, Maryland); Sangeeta Banerjee Ray (Baltimore, Maryland); Catherine A. Foss (Baltimore, Maryland) |
| ABSTRACT | Prostate-specific membrane antigen (PSMA)-targeted PAMAM dendrimers (G4-PSMA) and their use for imaging or treating PSMA-expressing tumors or cells are disclosed. |
| FILED | Friday, December 13, 2019 |
| APPL NO | 17/312548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/0041 (20130101) A61K 49/0054 (20130101) Original (OR) Class A61K 51/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054661 | DHARMAKUMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Rohan DHARMAKUMAR (Moorpark, California); Debiao LI (San Marino, California); Sotirios A. TSAFTARIS (Lucca, Italy) |
| ABSTRACT | There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/463073 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7076 (20130101) A61K 33/00 (20130101) A61K 49/08 (20130101) Original (OR) Class A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054662 | Pease et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonard F. Pease (Salt Lake City, Utah); Hedieh Saffari (Salt Lake City, Utah); Gerald J. Gleich (Salt Lake City, Utah); Kristin M. Leiferman (Salt Lake City, Utah); Kathryn A. Peterson (Salt Lake City, Utah); Russell Morris Condie (Salt Lake City, Utah) |
| ABSTRACT | Also disclosed are methods |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379402 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/08 (20130101) A61K 51/0491 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054704 | Kaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Ung-Jin Kim (Daejeon, South Korea); Jaehyung Park (Decatur, Georgia); Hyoung-Joon Jin (Seoul, South Korea) |
| ABSTRACT | The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466239 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) A61L 2430/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/003 (20130101) B29C 39/203 (20130101) B29C 55/005 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 7/01 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/00 (20130101) Peptides C07K 14/43536 (20130101) C07K 14/43586 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/07 (20130101) C08J 3/075 (20130101) C08J 5/18 (20130101) C08J 9/26 (20130101) C08J 9/28 (20130101) C08J 9/0061 (20130101) C08J 2201/0444 (20130101) C08J 2201/0504 (20130101) C08J 2205/022 (20130101) C08J 2389/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249921 (20150401) Y10T 442/10 (20150401) Y10T 442/60 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054708 | Murphy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Murphy (Waunakee, Wisconsin); Gianluca Fontana (Madison, Wisconsin); Joshua Gershlak (Worcester, Massachusetts); Glenn Gaudette (Worcester, Massachusetts); Pam Weathers (Worcester, Massachusetts); Tanja Dominko (Worcester, Massachusetts); Marsha Rolle (Worchester, Massachusetts); Sarah Hernandez (San Juan Capistrano, California); Carol Cramer (State University, Arkansas); Fabricio Medina-Bolivar (State University, Arkansas) |
| ABSTRACT | Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388652 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) A61L 27/3637 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 2300/25 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/04 (20130101) C12N 5/0068 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054746 | Patel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Irvine, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Himanshu Patel (Rancho Santa Margarita, California); Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts); Michael J. Rosinko (Las Vegas, Nevada) |
| ABSTRACT | Systems and methods presented herein relate to a method of sharing therapy data of an ambulatory medical device with a computing system of a networked computing environment. The computing system may be identified using an authorized system list that includes an address of approved computing systems. Using an address of an approved computing system, a direct end-to-end data connection may be established via a wireless wide area network. A public key of the computing system may be received permitting the ambulatory medical device to encrypt data to be transmitted to the computing system. The ambulatory medical device can transmit the encrypted therapy data to the computing system over the direct end-to-end data connection. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362363 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2205/18 (20130101) A61M 2205/52 (20130101) A61M 2205/3553 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054748 | DASSAU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Eyal DASSAU (Cambridge, Massachusetts); Dawei SHI (Cambridge, Massachusetts); Francis J. DOYLE III (Cambridge, Massachusetts) |
| ABSTRACT | A multivariate parameter adaptation approach is disclosed for long-term use of an artificial pancreas using a dual-layer control scheme. The adaptation problem, which can be treated as an optimization problem with an unknown objective function and constraints, may be solved by the proposed BO-assisted multivariate optimization approach. Results showed that the algorithm was able to identify the improperly tuned parameters and smoothly adjust them for improved glucose regulation, despite lifestyle disturbances. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/283859 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2005/1726 (20130101) A61M 2205/52 (20130101) A61M 2230/201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054844 | Asp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anders J. Asp (Rochester, Minnesota); Jose Luis L. Lujan (Byron, Minnesota) |
| ABSTRACT | In an example method for increasing synaptic gain in a region of a brain of a subject, a first electromagnetic pulse is applied to a first neural element of a first neuron of the subject using a first electrode. The first neural element includes a first synapse coupled to a second neuron of the subject. Subsequent to applying the first electromagnetic pulse to the first neural element, a second electromagnetic pulse is applied to a second neural element of the second neuron using a second electrode. |
| FILED | Wednesday, August 04, 2021 |
| APPL NO | 17/394366 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0529 (20130101) A61N 1/36125 (20130101) A61N 1/36167 (20130101) A61N 1/36192 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055035 | BROUZES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Eric BROUZES (Port Jefferson, New York); Martin SAUZADE (Setauket, New York) |
| ABSTRACT | This disclosure provides devices and methods for the isolation of single cells or particles of interest from a solution comprising a plurality of cells or a solution composed of a homogenous population of particles. Specifically, the present disclosure is directed to microfluidic devices and methods for analyzing cells in a sample. More specifically, the present disclosure provides droplet microfluidic devices and methods for using the same to obtain (trap), encapsulate, and retrieve (isolate) single cells or particles from a sample with improved efficiency. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518684 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0668 (20130101) B01L 2300/0816 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055040 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CIRCULOMICS INC. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelvin Jeng-Fang Liu (Baltimore, Maryland); Jeffrey Michael Burke (Baltimore, Maryland) |
| ABSTRACT | Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the magnetic silica nanomembranes can be used for solid phase extraction of nucleic acids. The magnetic silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of nucleic acid recovery yield and integrity. In addition, the magnetic silica nanomembranes may have high nucleic acid capacity due to significantly enlarged specific surface area of silica. Methods of use and devices comprising the magnetic silica nanomembranes are also provided herein. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518183 |
| CURRENT CPC | Separation B01D 15/424 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) B03C 1/30 (20130101) Original (OR) Class B03C 1/286 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/12 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/06 (20130101) C08J 2323/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1013 (20130101) C12N 15/1017 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 35/0098 (20130101) G01N 35/0099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055979 | RAINES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. RAINES (Madison, Wisconsin); Nicholas McGRATH (Fairmont, Minnesota) |
| ABSTRACT | A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R1 and R2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370829 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/18 (20130101) Original (OR) Class C07C 245/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055991 | Ravert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hayden T. Ravert (Bel Air, Maryland); Daniel P. Holt (Severna Park, Maryland); Ying Chen (Lutherville-Timonium, Maryland); Ronnie C. Mease (Fairfax, Virginia); Hong Fan (Timonium, Maryland); Martin G. Pomper (Baltimore, Maryland); Robert F. Dannals (Sparks, Maryland) |
| ABSTRACT | Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/195895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0455 (20130101) A61K 51/0497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) Heterocyclic Compounds C07D 213/42 (20130101) Original (OR) Class C07D 213/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055998 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts); Mingfeng Hao (Hefei, China PRC) |
| ABSTRACT | The present invention provides novel compounds of Formulae (I′), (I), (II′), and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., CDK7, CDK12, or CDK13), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378622 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 277/46 (20130101) Original (OR) Class C07D 417/04 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056002 | Soper et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | The University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Steven Allan Soper (Baton Rouge, Louisiana); Blake R. Peterson (Columbus, Ohio); Richard S. Givens (Lawrence, Kansas) |
| ABSTRACT | A photocleavable heterobifunctional linker can include a structure of Formula (A) wherein coumarin is any coumarin or coumarin derivative; R, R9, and R10 are each independently a chemical moiety; R1 is a hydrogen, protecting group, leaving group, substrate, or capture entity; R2 is a hydrogen, hydroxyl, halide, alkoxy, anhydride, amino, protecting group, leaving group, substrate, or capture entity; L1 is a sub-linker; and L2 is a sub-linker. A capture device can include the photocleavable bifunctional linker having a structure of Formula (A) as provide herein, wherein R1 is a substrate. A method of capturing a target substance can include: providing the capture device having the photocleavable bifunctional linker with the structure of Formula (A) and contacting a target substance to the capture moiety such that the target substance is captured. Irradiating the linker with light can cleave the linker, thereby releasing the target substance from the substrate. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 17/416172 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/16 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/547 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056100 | SPUDICH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | John L. SPUDICH (Houston, Texas); Oleg A. SINESHCHEKOV (Houston, Texas); Elena G. GOVORUNOVA (Houston, Texas) |
| ABSTRACT | Methods and compositions used to identify and characterize novel rhodopsin domains, which are anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned, optimized and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406670 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056116 | Frigault et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Frigault (Philadelphia, Pennsylvania); Yangbing Zhao (Lumberton, New Jersey); John Scholler (Narberth, Pennsylvania); Carl H. June (Merion Station, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318316 |
| CURRENT CPC | Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/30 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) C12N 2510/00 (20130101) C12N 2740/15041 (20130101) C12N 2840/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056128 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SHOOL OF MEDICINE AT MOUNT SINAI (New York, New York); THE METHODIST HOSPITAL (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shu-Hsia Chen (Houston, Texas); Ping-Ying Pan (Houston, Texas) |
| ABSTRACT | Antibodies and antibody fragments that specifically bind to LILRB2 are disclosed. Also provided herein are compositions comprising antibodies and antibody fragments that specifically bind to LILRB2 and methods of use thereof. Also provided are related chimeric antigen receptors (CARs) and cells comprising same (e.g., T cells, natural killer cells, or macrophages), and uses of the CARs and cells in targeting tumors and killing them, asthma treatment, or in targeting and removing infected cells (e.g., to treat infections or infectious diseases), or in suppressing immune system cells, as involved in autoimmune disease or transplant rejection. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 17/276324 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056129 | Diaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Diaz (Ellicot City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookville, Maryland) |
| ABSTRACT | Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056152 | GARCIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AQUALUNG THERAPEUTICS (TUCSON, Arizona) |
| ASSIGNEE(S) | AQUALUNG THERAPEUTICS (TUCSON, Arizona) |
| INVENTOR(S) | JOE G.N. GARCIA (TUCSON, Arizona); DARRAGH MACCANN (CO. DERRY, Ireland) |
| ABSTRACT | Anti-nicotinamide phosphoribosyltransferase (NAMPT) antibodies, or antigen binding fragments thereof, are described, as well as methods for treating a subject having a (NAMPT)-associated local and/or systemic inflammatory disorder. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056409 | SENTMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles L. SENTMAN (Grantham, New Hampshire) |
| ABSTRACT | The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/463605 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056420 | Wells et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Macormack Wells (Cincinnati, Ohio); Kyle William McCracken (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed gastric cells, gastric tissues, and/or gastric organoids derived from precursor cells. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/305196 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/16 (20130101) C12N 2501/113 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/155 (20130101) C12N 2501/385 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056429 | Landau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel R. Landau (New York, New York); Takuya Tada (New York, New York) |
| ABSTRACT | Provided are polypeptides comprising an enzymatically inactive angiotensin-converting enzyme 2 (ACE2) ectodomain, a segment of an immunoglobulin Fc and optionally a purification tag. A cDNA or an expression vector encoding the polypeptide along with a method of culturing cells comprising the expression vector is also provided. The disclosure also provides a method for prophylaxis or therapy for a Coronavirus infection by administering the polypeptide to an individual in need thereof. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4813 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 2319/21 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Original (OR) Class Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056453 | MILSOM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Michael MILSOM (Dossenheim, Germany); David A. WILLIAMS (Dover, Massachusetts); Richard GREGORY (Brookline, Massachusetts) |
| ABSTRACT | Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404576 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/113 (20130101) C12N 15/1135 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2740/10032 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056475 | DENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liang DENG (New York, New York); Jedd WOLCHOK (New York, New York); Stewart SHUMAN (New York, New York); Taha MERGHOUB (New York, New York); Ning YANG (New York, New York); Yi WANG (New York, New York); Gregory MAZO (New York, New York); Peihong DAI (New York, New York); Weiyi WANG (New York, New York) |
| ABSTRACT | Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of genetically engineered or recombinant poxviruses, including a modified vaccinia Ankara (MVA) virus comprising a deletion of E3L (MVAΔE3L) engineered to express OX40L (MVAΔE3L-OX40L), an MVA virus comprising a deletion of C7L (MVAΔC7L) engineered to express OX40L (MVAΔC7L-OX40L), a MVAΔC7L engineered to express OX40L and human Fms-like tyrosine kinase 3 ligand (hFlt3L) (MVAΔC7L-hFlt3L-OX40L), an MVA comprising a deletion of E5R (MVAΔE5R), a vaccinia virus comprising a deletion of C7L (VACVΔC7L) engineered to express OX40L (VACVΔC7L-OX40L), a VACVΔC7L engineered to express both OX40L and hFlt3L (VACVΔC7L-hFlt3L-OX40L), a VACV comprising a deletion of E5R (VACVΔE5R), a myxoma virus (MYXV) comprising a deletion of M31R (MYXVΔM31R), or combinations thereof, alone or in combination with other agents, as an oncolytic and immunotherapeutic composition. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 17/275974 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/137 (20130101) A61K 39/39 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/04 (20180101) Peptides C07K 14/54 (20130101) C07K 14/55 (20130101) C07K 14/71 (20130101) C07K 14/5434 (20130101) C07K 14/5443 (20130101) C07K 14/70575 (20130101) C07K 16/2818 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2710/24134 (20130101) C12N 2710/24143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056477 | van der Loo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johannes C.M. van der Loo (Newtown Square, Pennsylvania); David William Russell (Seattle, Washington); Punam Malik (Cincinnati, Ohio); Md Nasimuzzaman (Cincinnati, Ohio) |
| ABSTRACT | Disclosed are methods of preparing FV vector particles. In some aspects, the disclosed methods may include the steps of transfecting a population of eukaryotic cells by contacting said population of eukaryotic cells with one or more transfection reagents to form a transfection mixture, and incubating the transfection mixture to form a transfected cell population; harvesting the FV vector particles from said transfected cell population; purifying the FV vector particles; and concentrating the FV vector particles. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345127 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2740/17043 (20130101) C12N 2740/17051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056498 | KISHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits and methods for synthesis of nucleic acids. Also provided herein are compositions and methods for synthesizing strands of nucleic acid across different nucleic acid back-bones hybridized together using a strand displacing polymerase. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/415326 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056503 | Seelig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521263 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056527 | Murphy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barbara Murphy (Pelham Manor, New York); John Cijiang He (Forest Hills, New York) |
| ABSTRACT | A method for identifying the risk of developing Chronic Allograft Nephropathy (CAN) in a patient that received a kidney transplant from a donor which comprises identifying the race of the donor; determining the levels of SHROOM 3 expression in a kidney biopsy specimen obtained from the patient at a predetermined time after transplant; comparing the level of SHROOM 3 expression in the biopsy specimen with the levels of SHROOM 3 expression in a control; determining if the level of SHROOM 3 expression in the allograft is significantly higher than in the control, and diagnosing the patient as being at risk for CAN if the level of SHROOM 3 expression in the specimen is significantly higher than in the control. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409200 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/10 (20130101) G01N 2800/50 (20130101) G01N 2800/245 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057266 | Simpson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Garth Jason Simpson (West Lafayette, Indiana); Chen Li (West Lafayette, Indiana); Changqin Li (West Lafayette, Indiana) |
| ABSTRACT | A method for phase contrasting-correlation spectroscopy: converting an incident linearly polarized light into two polarized components (polarized divergent and convergent components, wherein the polarized divergent component is orthogonal to the polarized convergent component), focusing each of the polarized divergent component and the polarized convergent component into a focal plane, thereby producing two focus planes constituting a reference focus (RF) plane and a sample focus (SF) plane; placing a sample at the SF plane and ambient conditions of the sample at the RF plane, resulting in a phase shift between the two polarized components; reconstituting the two phase-shifted polarized components into a phase-shifted linearly polarized light; detecting the phase-shifted linearly polarized light; calculating phase and intensity of the sample from the phase-shifted linearly polarized light; establishing an autocorrelation of phase and intensity of the phase-shifted linearly polarized light; and generating correlograms of intensity and phase of the phase-shifted linearly polarized light. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518761 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) G01J 3/447 (20130101) Original (OR) Class G01J 2003/1291 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057328 | Paulsen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire); UNIVERSITY HEALTH NETWORK (Toronto, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith D. Paulsen (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire); Dennis Wirth (Hanover, New Hampshire); Brian C. Wilson (Toronto, Canada); Mira Sibai (Toronto, Canada) |
| ABSTRACT | A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516490 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4795 (20130101) G01N 21/6456 (20130101) Original (OR) Class G01N 33/4833 (20130101) G01N 2201/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057356 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongchao Zhang (Ellicott City, Maryland); Aeshah Alshehri (Tanomah, Saudi Arabia) |
| ABSTRACT | An electrochemical biosensor includes a working electrode modified with a redox polymer and amine-terminated capture aptamer specific for a particular detection target. The binding sequence of the capture aptamer is also complementary to part of a second ssDNA which is labeled with HRP (horseradish peroxidase). The capture aptamer will form dsDNA with the HRP-labeled ssDNA and bring HRP into electrical contact with the redox polymer and the electrode. Prior to capturing the detection target, addition of H2O2 will lead to the highest reduction current due to the redox polymer-mediated, enzyme-amplified electroreduction of H2O2. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243107 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3276 (20130101) G01N 27/3277 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057360 | Furtaw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LI-COR, Inc. (Lincoln, Nebraska) |
| ASSIGNEE(S) | LI-COR, Inc. (Lincoln, Nebraska) |
| INVENTOR(S) | Michael D. Furtaw (Lincoln, Nebraska); Donald T. Lamb (Lincolin, Nebraska) |
| ABSTRACT | A flat bar piezoelectric actuator affixed to a pressure chamber with one or more separation capillary tubes exiting near respective nozzle orifices is disclosed. The flat actuator against a flat wall of the pump chamber causes a relatively planar pressure wave to pass by the end of each capillary, transporting a precise amount of separated analyte from the capillary out of the nozzle orifice. The nozzle may or may not be tapered. Multiple nozzles can form an inkjet print head that ejects precise droplets of analyte and sheath fluid. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518430 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44739 (20130101) Original (OR) Class G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057371 | Wempe et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael F. Wempe (Aurora, Colorado); Johan L. Van Hove (Castle Rock, Colorado); Curtis Coughlin, II (Denver, Colorado) |
| ABSTRACT | Methods for determining the presence or amount of oxopiperidine in a biological sample using mass spectrometry. These methods may be used to efficiently and non-invasively diagnose pyridoxine dependent epilepsy (PDE) due to deficient a-aminoadipic-δ-semialdehyde (α-AASA) dehydrogenase activity due to mutations in ALDH7A1, resulting in the accumulation of Δ1-P6C, P6CH, and 6-Oxo-PIP in biological samples. |
| FILED | Tuesday, February 19, 2019 |
| APPL NO | 16/971103 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/7233 (20130101) Original (OR) Class G01N 2030/027 (20130101) G01N 2560/00 (20130101) G01N 2800/2857 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057388 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Rong Fan (Cheshire, Connecticut); Yao Lu (New Haven, Connecticut); Jonathan Chen (San Jose, California) |
| ABSTRACT | The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204279 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) G01N 33/54366 (20130101) Original (OR) Class G01N 33/54386 (20130101) G01N 2570/00 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057398 | Sarvetnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Nora E. Sarvetnick (Omaha, Nebraska); Robert Z. Harms (Omaha, Nebraska) |
| ABSTRACT | In various embodiments methods are provided for evaluating the likelihood of a subject progressing to type 1 diabetes. In certain embodiments the methods involve determining the level of CD57+, CD28−, CD127−, CD27−, CD8+ T cells (SLEC CD8 T cells) and the other populations shown in FIG. 10 and/or CCR7dim, CD45RA+, CD8+ T cells derived from a subject where an elevated level of the first populations above, and/or a reduced level of the CCR7dim, CD45RA+, CD8+ T cells as compared to the level(s) in a normal healthy control is an indicator that subject has a significant elevated risk for progression to type I diabetes. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/250844 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057400 | Lee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter P. Lee (San Marino, California) |
| ABSTRACT | The disclosure provides, inter alia, methods of detecting IL-6 signaling activity in T cells in breast cancer patients, such as breast cancer patients in remission. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511327 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 33/57415 (20130101) Original (OR) Class G01N 2333/4703 (20130101) G01N 2333/5412 (20130101) G01N 2333/7155 (20130101) G01N 2800/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057402 | da Silva et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seagen Inc. (Bothell, Washington) |
| ASSIGNEE(S) | Seagen Inc. (Bothell, Washington) |
| INVENTOR(S) | Ana Paula Galvao da Silva (San Diego, California); Darius Ghaderi (Laupheim, Germany); Mai Zhang (Carlsbad, California); Kristan Meetze (Lexington, Massachusetts); Julie DeSander (Arlington, Massachusetts); Jeffrey Behrens (Newton, Massachusetts); David A. Eavarone (Newton, Massachusetts); Jillian M. Prendergast (Maynard, Massachusetts) |
| ABSTRACT | The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331290 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6817 (20170801) A61K 47/6851 (20170801) Peptides C07K 16/005 (20130101) C07K 16/44 (20130101) C07K 16/3076 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2317/732 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057464 | YU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yihua (Bruce) YU (Ellicott City, Maryland); Marc B. TARABAN (North Potomac, Maryland) |
| ABSTRACT | Provided herein are methods for using water proton transverse relaxation rate R2(T) to monitor in real time the sedimentation process of multiphase mixtures such as drug products and drug substances. Using wNMR (water proton nuclear magnetic resonance), valuable information can be obtained regarding sedimentation rate, dynamics of supernatant and sediment buildup, and sedimentation volume ratio (SVR) reflecting the compactness of formed sediment in such mixtures. The results described herein demonstrate the practical applicability of wNMR as an analytical tool to study and provide higher quality and more efficient multiphase mixtures. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401709 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/04 (20130101) G01N 24/082 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) Original (OR) Class G01R 33/34092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057902 | KWIECIEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas William KWIECIEN (Madison, Wisconsin); Michael Scott WESTPHALL (Fitchburg, Wisconsin); Joshua Jacques COON (Middleton, Wisconsin) |
| ABSTRACT | The present invention provides a platform that enables codeless generation of online mass spectrometry data exploration portals. The platform facilitates upload of generic spreadsheets containing processed mass spectrometry results (e.g., peak tables) and enables on-the-fly hierarchical organization of data. Following data upload, platform users can select individual visualizations to add to their custom web portal from a menu of options. Based on these selections, a complete webpage is constructed with all associated functionality embedded. These custom web portals can then be shared with collaborators and other researchers at the discretion of the creator via a developed user permissions sharing scheme. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360806 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0482 (20130101) Original (OR) Class G06F 16/95 (20190101) G06F 16/958 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/101 (20130101) Image Data Processing or Generation, in General G06T 11/206 (20130101) G06T 2200/24 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/10 (20130101) H04L 63/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058052 | Birnbaum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Leica Microsystems CMS GmbH (Wetzlar, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Birnbaum (Issaquah, Washington); Shih-Jong James Lee (Bellevue, Washington); Tuan Phan (Lynnwood, Washington) |
| ABSTRACT | A computerized efficient data processing management method for imaging applications first performs a data flow graph generation by computing means using at least one image data and at least one requested task to generate a data flow graph. The method then applies a task execution scheduling using the data flow graph generated, a caching system configuration, the at least one image data and at least one requested task to schedule execution of the at least one requested task to generate task execution output. In addition, an adaptive data processing method performs caching system update and an optimal data processing method further performs data flow graph update. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/000174 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3005 (20130101) G06F 9/4881 (20130101) Original (OR) Class G06F 9/5061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058369 | Alahmari et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); STEREOLOGY RESOURCE CENTER, INC. (Saint Petersburg, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeed S. Alahmari (Tampa, Florida); Dmitry Goldgof (Tampa, Florida); Lawrence O. Hall (Tampa, Florida); Peter R. Mouton (Tampa, Florida) |
| ABSTRACT | Systems and methods for automated stereology are provided. In some embodiments, an active deep learning approach may be utilized to allow for a faster and more efficient training of a deep learning model for stereology analysis. In other embodiments, existing deep learning models for stereology analysis may be re-tuned to develop greater accuracy for a given data set of interest, either with or without an active deep learning approach. A method can include: capturing a data set including a stack of images of a three-dimensional (3D) object; determining whether an existing deep learning model is appropriate for use on the stack of images (or for re-tuning); performing pre-processing on the data set; performing a training of a deep learning model; applying the deep learning model to obtain a confidence score for each label of the data set; reviewing, by a user, at least some labels in the active set to verify whether the label displays sufficient agreement with an expected result, and moving only those that display sufficient agreement to a training set; and performing a stereology analysis using the trained deep learning model. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397891 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/367 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/40 (20130101) G06K 9/00134 (20130101) Original (OR) Class G06K 9/00201 (20130101) G06K 9/342 (20130101) G06K 9/6227 (20130101) G06K 9/6256 (20130101) G06K 9/6263 (20130101) G06K 2209/05 (20130101) G06K 2209/27 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058809 | FUCHS et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Thomas FUCHS (New York, New York); David Joon HO (New York, New York) |
| ABSTRACT | Described herein are systems and methods of training models to segment images. A device may identify a training dataset. The training dataset may include images each having a region of interest. The training dataset may include first annotations. The device may train, using the training dataset, an image segmentation model having parameters to generate a corresponding first segmented images. The device may provide the first segmented images for presentation on a user interface to obtain feedback. The device may receive, via the user interface, a feedback dataset including second annotations for at least a subset of the first segmented images. Each of the second annotations may label at least a second portion of the region of interest in a corresponding image of the subset. The device may retrain, using the feedback dataset received via the user interface, the image segmentation model. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516255 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6202 (20130101) G06K 9/6267 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/187 (20170101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30024 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058839 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | Young Hwan Chang (Portland, Oregon); Erik Burlingame (Portland, Oregon); Geoffrey Schau (Portland, Oregon); Joe W. Gray (Lake Oswego, Oregon) |
| ABSTRACT | Techniques and systems for translating images of biological samples stained according to a first staining technique into images representing the biological samples stained according to a second staining technique. In various implementations, the first staining technique can include a histopathological staining technique and the second staining technique can include an immunofluorescence staining technique or an immunohistochemistry staining technique. |
| FILED | Monday, December 30, 2019 |
| APPL NO | 17/419693 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) G06N 3/0472 (20130101) Image Data Processing or Generation, in General G06T 7/32 (20170101) G06T 11/00 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220054067 | SHAH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adhvait SHAH (Chelmsford, Massachusetts); Jan BERKOW (Chelmsford, Massachusetts); Asimina KIOURTI (Columbus, Ohio); Keren ZHU (Columbus, Ohio) |
| ABSTRACT | An electromagnetic bio-signal detector to monitor very weak evoked action potentials associated with neurotransmissions is described. The small induction-coil array detector and integrated circuit design enables the device to have a small and possibly portable form factor while minimizing cost. Advanced signal processing methods enables the device to detect very weak electromagnetic signals without the need for shielding to reduce electromagnetic background emissions. The combination of cost, size, and sensitivity affords the electromagnetic bio-signal detector broad utility both inside and outside hospital settings and for numerous diagnostic and treatment feedback applications. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407862 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/30 (20210101) Original (OR) Class A61B 5/248 (20210101) A61B 5/7203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054608 | SCOTT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. SCOTT (Bethesda, Maryland); Yongchan KIM (Rockville, Maryland); Aihong ZHANG (Ellicott City, Maryland) |
| ABSTRACT | Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or bi-specific antibodies. The agents and methods can be used to reduce undesirable immune responses. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 21/04 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 5/0638 (20130101) C12N 2502/1107 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054610 | Deleyrolle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loic Pierre Deleyrolle (Gainesville, Florida); Elias Sayour (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides compositions comprising a liposome comprising a cationic lipid and nucleic acid molecules comprising a sequence of a nucleic acid molecule expressed by slow-cycling cells (SCCs). The present disclosure also provides methods of preparing an anti-tumor liposome composition. In exemplary embodiments, the method comprises (a) isolating SCCs from a mixed tumor cell population in accordance with any one of the presently disclosed in vitro method of isolating SCCs from a mixed tumor cell population, (b) extracting nucleic acid molecules from the isolated SCCs, and (c) mixing the nucleic acid molecules with a cationic lipid to make an anti-tumor liposome composition. The method of preparing an anti-tumor liposome composition in alternative embodiments comprises mixing at least one SCC transcriptome nucleic acid molecule as described herein with a cationic lipid to make an anti-tumor liposome composition. Tumor treatment methods are furthermore provided by the present disclosure. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/275399 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/80 (20180801) A61K 2039/55555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054704 | Kaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Ung-Jin Kim (Daejeon, South Korea); Jaehyung Park (Decatur, Georgia); Hyoung-Joon Jin (Seoul, South Korea) |
| ABSTRACT | The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466239 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) A61L 2430/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/003 (20130101) B29C 39/203 (20130101) B29C 55/005 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 7/01 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/00 (20130101) Peptides C07K 14/43536 (20130101) C07K 14/43586 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/07 (20130101) C08J 3/075 (20130101) C08J 5/18 (20130101) C08J 9/26 (20130101) C08J 9/28 (20130101) C08J 9/0061 (20130101) C08J 2201/0444 (20130101) C08J 2201/0504 (20130101) C08J 2205/022 (20130101) C08J 2389/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249921 (20150401) Y10T 442/10 (20150401) Y10T 442/60 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054985 | Pozzo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Lilo D. Pozzo (Seattle, Washington); Anthony William Moretti (Seattle, Washington); Gregory M. Newbloom (Seattle, Washington); Aaron West (Seattle, Washington); Eden Rivers (Seattle, Washington) |
| ABSTRACT | Disclosed herein are ceramic selective membranes and methods of forming the ceramic selective membranes by forming a selective silica ceramic on a porous membrane substrate. |
| FILED | Monday, December 21, 2020 |
| APPL NO | 17/129528 |
| CURRENT CPC | Separation B01D 39/2068 (20130101) B01D 61/025 (20130101) B01D 67/0048 (20130101) Original (OR) Class B01D 67/0076 (20130101) B01D 67/0079 (20130101) B01D 67/0088 (20130101) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 69/105 (20130101) B01D 69/148 (20130101) B01D 71/02 (20130101) B01D 71/26 (20130101) B01D 71/027 (20130101) B01D 71/28 (20130101) B01D 71/76 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/106 (20130101) H01M 8/188 (20130101) H01M 8/0236 (20130101) H01M 8/0239 (20130101) H01M 8/0245 (20130101) H01M 8/1016 (20130101) H01M 8/1053 (20130101) H01M 8/1062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055008 | Jones |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan P. Jones (Hanover, Maryland) |
| ABSTRACT | A reactor includes a first outer tube configured to contain a working fluid, and a first inner tube disposed in the first outer tube. The first inner tube is configured to contain a source of heat to transfer or absorb heat to or from the working fluid. The reactor further includes a second inner tube in the first outer tube. The second inner tube is wound around the first inner tube in a helical fashion, and the second inner tube is configured absorbs heat from and/or dissipates heat to the working fluid, and/or facilitate a reaction in a reactant contained in the second inner tube. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336489 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0013 (20130101) Original (OR) Class B01J 19/123 (20130101) B01J 19/125 (20130101) B01J 19/126 (20130101) B01J 19/128 (20130101) B01J 19/2415 (20130101) B01J 2219/00054 (20130101) B01J 2219/00087 (20130101) B01J 2219/00141 (20130101) B01J 2219/00146 (20130101) B01J 2219/2416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055013 | Leventis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| ASSIGNEE(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| INVENTOR(S) | Nicholas Leventis (Worcester, None); Chariklia Sotiriou-Leventis (Rolla, None); Malik Adnan Saeed (Rolla, None) |
| ABSTRACT | The present invention discloses novel porous polymeric compositions comprising random copolymers of amides, imides, ureas, and carbamic-anhydrides, useful for the synthesis of monolithic bimodal microporous/macroporous carbon aerogels. It also discloses methods for producing said microporous/macroporous carbon aerogels by the reaction of a polyisocyanate compound and a polycarboxylic acid compound, followed by pyrolytic carbonization, and by reactive etching with CO2 at elevated temperatures. Also disclosed are methods for using the microporous/macroporous carbon aerogels in the selective capture and sequestration of carbon dioxide. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493306 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/102 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) B01J 13/0091 (20130101) B01J 20/20 (20130101) Original (OR) Class B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/28042 (20130101) B01J 20/28047 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/00 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/346 (20130101) C08G 18/7664 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/36 (20130101) C08J 9/286 (20130101) C08J 2201/0543 (20130101) C08J 2205/05 (20130101) C08J 2205/026 (20130101) C08J 2205/044 (20130101) C08J 2205/048 (20130101) C08J 2375/02 (20130101) C08J 2375/04 (20130101) C08J 2379/08 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/104 (20130101) C10L 2290/542 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 20/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055033 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BioFire Diagnostics, LLC. (Salt Lake City, Utah); BioFire Defense, LLC. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle K. Johnson (Eagle Mountain, Utah); Owen D. Brimhall (South Jordan, Utah); Jonathan J. Politis (Riverton, Utah) |
| ABSTRACT | Instruments and methods for amplifying nucleic acids in a sample provided in a flexible, self-contained, substantially closed sample container. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/372082 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 7/525 (20130101) B01L 2200/14 (20130101) B01L 2200/027 (20130101) B01L 2200/0621 (20130101) B01L 2200/0647 (20130101) B01L 2300/044 (20130101) B01L 2300/0627 (20130101) B01L 2300/0861 (20130101) B01L 2300/1822 (20130101) B01L 2300/1827 (20130101) B01L 2400/0481 (20130101) B01L 2400/0683 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/066 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055470 | Avenatti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Matthew Avenatti (Bloomington, Indiana); Tyler Allen Mullis (Bloomfield, Indiana); Braden Matthew Yake (Bloomington, Indiana); Jason Everett Miller (Jasonville, Indiana); Ryan Wynne (Olympia Fields, Illinois); Lucas Allison (Madison, Alabama); Joseph Patrick Bailey (Bloomington, Indiana); Al Bodey (Carmel, Indiana) |
| ABSTRACT | The present invention relates to electric drivetrain kits for converting all-terrain vehicles into hybrid or electric vehicles. In exemplary embodiments, a conversion kit replaces an existing standard single motor and transmission drive system with a dual set-up including a motor for each rear wheel and a split transmission that houses two sets of gear reduction components in a single housing or an all-wheel configuration with two transmission sets (front and rear). Dual output shafts in each transmission set drive the wheels independently to provide the torque needed as required and demanded by each wheel. System electronics send signals to the motors and other components to manage the system and independently control each wheel. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402945 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 1/02 (20130101) B60K 6/40 (20130101) Original (OR) Class B60K 6/52 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/16 (20190201) B60L 2200/46 (20130101) Servicing, Cleaning, Repairing, Supporting, Lifting, or Manoeuvring of Vehicles, Not Otherwise Provided for B60S 11/00 (20130101) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055891 | Knick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cory R. Knick (Alexandria, Virginia); Christopher J. Morris (Silver Spring, Maryland); Gabriel L. Smith (Ellicott City, Maryland) |
| ABSTRACT | A microelectromechanical system (MEMS) actuator device includes a substrate; a shape memory alloy over the substrate; and a reflective coating on the shape memory alloy. The shape memory alloy and the reflective coating form a bi-layer cantilever beam having a first end anchored to the substrate, and a second end released from the substrate. The second end of the cantilever beam articulates between a deflection configuration away from the substrate and a non-deflection configuration towards the substrate based on a thermal phase change in the shape memory alloy. |
| FILED | Thursday, August 20, 2020 |
| APPL NO | 16/998458 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0081 (20130101) Original (OR) Class B81B 3/0083 (20130101) B81B 7/04 (20130101) B81B 2203/0118 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055904 | Tour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (Beer-Sheva, Israel); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (Beer-Sheva, Israel); WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | James Mitchell Tour (Bellaire, Texas); Duy X. Luong (Houston, Texas); Kaichun Yang (Houston, Texas); Christopher John Arnusch (Midreshet Ben-Gurion, Israel); Swatantra Pratap Singh (Midreshet Ben-Gurion, Israel); Amit Kumar Thakur (Beer-Sheva, Israel); Michael G. Stanford (Houston, Texas); John T. Li (Houston, Texas); Steven E. Presutti (Houston, Texas) |
| ABSTRACT | Resistive memory devices having laser-induced graphene (LIG) composites, and methods of making resistive memory devices having LIG composites. |
| FILED | Monday, December 30, 2019 |
| APPL NO | 17/419231 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) C01B 32/194 (20170801) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/24 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/587 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056075 | ZADINA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); DEPARTMENT OF VETERANS AFFAIRS (US) (Washington, District of Columbia) |
| ASSIGNEE(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); DEPARTMENT OF VETERANS AFFAIRS (US) (Washington, District of Columbia) |
| INVENTOR(S) | James E. ZADINA (Metaire, Louisiana) |
| ABSTRACT | A method for treating opioid use disorder comprises administering to a subject a pharmaceutical composition comprising a cyclic peptide of Formula I or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier; wherein the peptide of formula X1-c[X2-X3-Phe-X4]-X5 is administered in place of, and as a substitute for an opioid to which the subject is addicted. X1 is Tyr or 2,6-Dmt; X2 is an acidic or basic D-amino acid; X3 is Trp or Phe; there is an amide bond between the sidechains of X2 and X4; X5 is NHR (R=H or alkyl) or an amino acid amide. When X2 is an acidic D-amino acid, X4 is a basic amino acid, X3 is Phe, and X5 is NHR; and when X2 is a basic D-amino acid, X4 is an acidic amino acid, and X3 is Trp. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056161 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Levi Michael Joseph Moore (Lancaster, California); Jacob C. Marcischak (Tehachapi, California); Timothy S. Haddad (Lancaster, California); Kamran B. Ghiassi (Palmdale, California); Gregory R. Yandek (Tehachapi, California) |
| ABSTRACT | The present invention relates to articles comprising crosslinked polymer network comprising thioether crosslinks and process of making and using same. Such thiol-ene crosslinking reactions not only make the isocyanate crosslinking reaction unnecessary, but they also improve the article's strength due to chemical crosslinking between the article's resin layers, and reduce or eliminate post curing. Thus resulting in a sufficiently cured article in a much shorter time. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395327 |
| CURRENT CPC | Treatment or Chemical Modification of Rubbers C08C 19/20 (20130101) C08C 19/28 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 9/06 (20130101) C08L 11/00 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056218 | Hancock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| ASSIGNEE(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| INVENTOR(S) | Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts) |
| ABSTRACT | Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/997837 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056220 | Mirkin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Janet R. McMillan (Evanston, Illinois); Oliver G. Hayes (Evanston, Illinois) |
| ABSTRACT | The present disclosure is generally directed to methods for making protein polymers. The methods comprise utilizing oligonucleotides for controlling the association pathway of oligonucleotide-functionalized proteins into oligomeric/polymeric materials. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275896 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/00 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 89/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056281 | FREITAG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas W. FREITAG (Brookeville, Maryland); Arthur J. GAVRIN (Manchester, New Hampshire) |
| ABSTRACT | Devices and methods are provided to apply thin layers of antimicrobial coatings onto a wide variety of substrates and articles. The methods can be performed at moderate temperatures and pressures, allowing for the coating of sensitive substrates and articles. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336921 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/03 (20130101) B05B 5/0533 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/62 (20130101) B05D 3/142 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) Original (OR) Class C09D 7/20 (20180101) C09D 7/61 (20180101) C09D 7/63 (20180101) C09D 7/65 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056450 | YAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao YAN (Chandler, Arizona); Yung CHANG (Tempe, Arizona); Xiaowei LIU (Tempe, Arizona); Fei ZHANG (Chandler, Arizona); Xiaodong QI (Tempe, Arizona) |
| ABSTRACT | Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory). |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520113 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/117 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056498 | KISHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits and methods for synthesis of nucleic acids. Also provided herein are compositions and methods for synthesizing strands of nucleic acid across different nucleic acid back-bones hybridized together using a strand displacing polymerase. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/415326 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057159 | Hoffman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Brian R. Hoffman (Bloomington, Indiana); Caleb W. McGee (Bloomington, Indiana); John David Lawrence (Bloomington, Indiana); Calvin Tyler Lawson (Springville, Indiana) |
| ABSTRACT | Provided is a firearm cartridge chamber with a relief feature that traps a portion of a cartridge case within the cartridge chamber when fired. The relief feature causes the cartridge case to deform within the chamber, wherein it optionally separates into a forward section and a rearward section. The deformed case remains trapped after firing, preventing extraction of the fired case and the chambering or firing of any subsequent cartridges, thereby causing a firearm malfunction. The cartridge chamber can distinguish between higher and lower pressure cartridges by allowing for normal firing and function with blank training ammunition while also facilitating localized deformation of the cartridge case when firing standard ammunition that includes one or more projectiles. The inventive chamber prevents more than one higher pressure round from firing while allowing lower pressure or training rounds to fire without limitation, which aids in enhanced safety during training exercises. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375072 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 17/34 (20130101) Original (OR) Class F41A 21/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057357 | Quevy et al. |
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| FUNDED BY |
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| APPLICANT(S) | ProbiusDx, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanuel Philippe Quevy (El Cerrito, California); Chaitanya Gupta (Redwood City, California); Jeremy Hui (San Francisco, California) |
| ABSTRACT | An all-electronic high-throughput detection system can perform multiple detections of one or more analyte in parallel. The detection system is modular, and can be easily integrated with existing microtiter plate technologies, automated test equipments and lab workflows (e.g., sample handling/distribution systems). The detection system includes multiple sensing modules that can perform separate analyte detection. A sensing module includes a platform configured to couple to a sample well. The sensing module also includes a sensor coupled to the platform. The sensing module further includes a first electrode coupled to the platform. The first electrode is configured to electrically connect with the sensor via a feedback circuit. The feedback circuit is configured to provide a feedback signal via the first electrode to a sample received in the sample well, the feedback signal based on a potential of the received sample detected via a second electrode. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358909 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3273 (20130101) G01N 27/4045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057378 | Hasty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Hasty (Encinitas, California); Leo Alexander Baumgart (San Diego, California); Scott Cookson (Encinitas, California); Michael Ferry (San Diego, California); Garrett Graham (San Diego, California); Ramon Huerta (San Diego, California); Ryan Johnson (San Diego, California); Lev Tsimring (San Diego, California) |
| ABSTRACT | Provided are a microfluidic biosensors that are suitable for continuously monitoring toxin levels in water supplies. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465090 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 2300/023 (20130101) B01L 2300/0654 (20130101) B01L 2400/0481 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 41/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) C12Q 1/6897 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/1813 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057387 | Glavin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas R. Glavin (Springboro, Ohio); Christopher Muratore (Kettering, Ohio); Melani K. Muratore (Kettering, Ohio) |
| ABSTRACT | The present invention relates to sensor arrays that are more accurate, more sensitive, and more specific with respect to the material that is detected and capable of detecting one or more materials over a wide range. Such sensor arrays can comprises sensors comprising pattern illumination-based annealed coated substrate and one or more functional molecules and process of using same. The method of designing and process of making the sensors for such sensor array yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film and to which one or more functional molecules can be attached to yield a sensor. Such processes when coupled with the design methods provided herein, allow for the rapid, efficient device prototyping, design change and evolution in the lab and on the production side. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523705 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0623 (20130101) C23C 14/5813 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) G01N 33/5438 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057389 | Kidwell |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kidwell (Alexandria, Virginia) |
| ABSTRACT | The present invention provides for a release system for delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related method of delaying application of chemical reagents in a lateral-flow immunoassay. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407154 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/29 (20130101) G01N 21/78 (20130101) G01N 33/525 (20130101) G01N 33/54388 (20210801) Original (OR) Class G01N 2201/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057400 | Lee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter P. Lee (San Marino, California) |
| ABSTRACT | The disclosure provides, inter alia, methods of detecting IL-6 signaling activity in T cells in breast cancer patients, such as breast cancer patients in remission. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511327 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 33/57415 (20130101) Original (OR) Class G01N 2333/4703 (20130101) G01N 2333/5412 (20130101) G01N 2333/7155 (20130101) G01N 2800/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057573 | Lopez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Josue Lopez (South Gate, California); Samuel Kim (Cambridge, Massachusetts); Jamison Sloan (Somerville, Massachusetts); Boris KHARAS (Needham, Massachusetts); Jeffrey Scott HERD (Rowley, Massachusetts); Marin SOLJACIC (Belmont, Massachusetts); Cheryl Marie SORACE-AGASKAR (Bedford, Massachusetts); Suraj Deepak BRAMHAVAR (Arlington, Massachusetts); Steven Glenn JOHNSON (Arlington, Massachusetts); George BARBASTATHIS (Boston, Massachusetts) |
| ABSTRACT | An integrated optical beam steering device includes a planar Luneburg lens that collimates beams from different inputs in different directions within the lens plane. It also includes a curved (e.g., semi-circular or arced) grating coupler that diffracts the collimated beams out of the lens plane. The beams can be steered in the plane by controlling the direction along which the lens is illuminated and out of the plane by varying the beam wavelength. Unlike other beam steering devices, this device can operate over an extremely wide field of view—up to 180°—without any aberrations off boresight. In other words, the beam quality is uniform in all directions, unlike with aplanatic lenses, thanks to the circular symmetry of the planar Luneburg lens, which may be composed of subwavelength features. The lens is also robust to misalignment and fabrication imperfections and can be made using standard CMOS processes. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496817 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/124 (20130101) Original (OR) Class G02B 6/125 (20130101) G02B 6/12004 (20130101) G02B 2006/12102 (20130101) G02B 2006/12107 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/2955 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057800 | Perkins et al. |
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| FUNDED BY |
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| APPLICANT(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Alexander Douglas Perkins (Arlington, Massachusetts); Kevin Blankespoor (Arlington, Massachusetts) |
| ABSTRACT | An example implementation includes (i) receiving sensor data that indicates topographical features of an environment in which a robotic device is operating, (ii) processing the sensor data into a topographical map that includes a two-dimensional matrix of discrete cells, the discrete cells indicating sample heights of respective portions of the environment, (iii) determining, for a first foot of the robotic device, a first step path extending from a first lift-off location to a first touch-down location, (iv) identifying, within the topographical map, a first scan patch of cells that encompass the first step path, (v) determining a first high point among the first scan patch of cells; and (vi) during the first step, directing the robotic device to lift the first foot to a first swing height that is higher than the determined first high point. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/453270 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) Motor Vehicles; Trailers B62D 57/032 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/021 (20130101) Original (OR) Class G05D 1/0212 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058298 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Siemens Industry Software Inc. (Plano, Texas); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashish Gupta (Marietta, Georgia); Kelsey Kurzeja (Atlanta, Georgia); Jaroslaw Rossignac (Atlanta, Georgia); Suraj Ravi Musuvathy (Princeton Junction, New Jersey); George Allen (Okinawa, Japan); Mark R. Burhop (Ewing, New Jersey); Livio Dalloro (Plainsboro, New Jersey) |
| ABSTRACT | Methods and systems are disclosed for a computer aided design system for designing multilevel lattice structures. A coarse lattice module defines a coarse lattice of balls connected by beams within a first boundary. A fine lattice module defines a fine lattice of balls connected by beams within a second boundary. The coarse lattice and the fine lattice have intersecting regions. A trimming module constructs a multilevel lattice structure according to a trimming operation based on the intersecting regions. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/274461 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/10 (20200101) Original (OR) Class G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058468 | Gadfort et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Gadfort (Washington, District of Columbia); Oluseyi Ayorinde (Marina Del Rey, California) |
| ABSTRACT | A field programmable neural array is an integrated circuit designed for artificial intelligence applications at the tactical computing edge. This platform combines a domain specific accelerator for AI with a reconfigurable interconnect to permit a deep neural network to be mapped into the field programmable neural array. The field programmable neural array includes domain specific accelerators that perform inference tasks with higher computing efficiency than central processing units and graphics processing units, approaching that of application-specific integrated circuits designed specifically for AI applications, and a reconfigurable interconnect providing the flexibility and connectivity of a field programmable gate array with lower power consumption. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 16/999257 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class G06N 3/0445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059352 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); James C. Gallagher (Alexandria, Virginia); Marko J. Tadjer (Vienna, Virginia); Alan G. Jacobs (Arlington, Virginia); Boris N. Feigelson (Springfield, Virginia) |
| ABSTRACT | A method for activating implanted dopants and repairing damage to dopant-implanted GaN to form n-type or p-type GaN. A GaN substrate is implanted with n- or p-type ions and is subjected to a high-temperature anneal to activate the implanted dopants and to produce planar n- or p-type doped areas within the GaN having an activated dopant concentration of about 1018-1022 cm−3. An initial annealing at a temperature at which the GaN is stable at a predetermined process temperature for a predetermined time can be conducted before the high-temperature anneal. A thermally stable cap can be applied to the GaN substrate to suppress nitrogen evolution from the GaN surface during the high-temperature annealing step. The high-temperature annealing can be conducted under N2 pressure to increase the stability of the GaN. The annealing can be conducted using laser annealing or rapid thermal annealing (RTA). |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/520821 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/266 (20130101) H01L 21/3245 (20130101) H01L 21/26546 (20130101) Original (OR) Class H01L 21/28575 (20130101) H01L 29/36 (20130101) H01L 29/207 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059353 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); James C. Gallagher (Alexandria, Virginia); Marko J. Tadjer (Vienna, Virginia); Alan G. Jacobs (Arlington, Virginia); Boris N. Feigelson (Springfield, Virginia) |
| ABSTRACT | A method for activating implanted dopants and repairing damage to dopant-implanted GaN to form n-type or p-type GaN. A GaN substrate is implanted with n- or p-type ions and is subjected to a high-temperature anneal to activate the implanted dopants and to produce planar n- or p-type doped areas within the GaN having an activated dopant concentration of about 1018-1022 cm−3. An initial annealing at a temperature at which the GaN is stable at a predetermined process temperature for a predetermined time can be conducted before the high-temperature anneal. A thermally stable cap can be applied to the GaN substrate to suppress nitrogen evolution from the GaN surface during the high-temperature annealing step. The high-temperature annealing can be conducted under N2 pressure to increase the stability of the GaN. The annealing can be conducted using laser annealing or rapid thermal annealing (RTA). |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/520830 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/266 (20130101) H01L 21/3245 (20130101) H01L 21/26546 (20130101) Original (OR) Class H01L 21/28575 (20130101) H01L 29/36 (20130101) H01L 29/207 (20130101) H01L 29/452 (20130101) H01L 29/2003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059878 | McCoy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CAMX Power LLC (Lexington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher H. McCoy (Sherborn, Massachusetts) |
| ABSTRACT | A process and system for measuring internal faults in an electrochemical cell is provided. The process for detecting an internal fault in an electrochemical cell includes measuring a voltage difference or a rate of change in voltage difference between a common terminal of a first electrochemical cell and a second electrochemical cell. The first electrochemical cell or second electrochemical cell is accepted based on the measuring, or first electrochemical cell or second electrochemical cell is rejected based on the measure of the internal fault of the electrochemical cell. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518030 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/3835 (20190101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/482 (20130101) H01M 10/4285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220060668 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of HarvardCollege (Cambridge, Massachusetts); Massachusetts Institute ofTechnology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donggyu Kim (Cambridge, Massachusetts); Alexander Keesling Contreras (Boston, Massachusetts); Ahmed Omran (Somervill, Massachusetts); Harry Jay Levine (Cambridge, Massachusetts); Hannes Bernien (Somerville, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Dirk R. Englund (Cambridge, Massachusetts) |
| ABSTRACT | A method of generating uniform large-scale optical focus arrays (LOT As) with a phase spatial light modulator includes identifying and removing undesired phase rotation in the iterative Fourier transform algorithm (IFTA), thereby producing computer-generated holograms of highly uniform LOT As using a reduced number of iterations as compared to a weighted Gerch-berg-Saxton algorithm. The method also enables a faster compensation of optical system-induced LOT A intensity inhomogeneity than the conventional IFTA. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432723 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 9/317 (20130101) H04N 9/3102 (20130101) H04N 9/3138 (20130101) Original (OR) Class H04N 9/3197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220054111 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dian-Ru Li (Ann Arbor, Michigan); Jeffrey Stephen Plott (Algonac, Michigan); Jeffrey Montgomery (Ann Arbor, Michigan); Albert J. Shih (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure relates to devices, systems, and methods for performing needle biopsies. In particular, provided herein is a biopsy device comprising an asymmetric stylet tip with multiple bevels and uses thereof. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/312501 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0241 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054255 | Detamore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Kansas (Lawrence, Kansas); The Children's Mercy Hospital (Kansas City, Missouri) |
| ASSIGNEE(S) | The University of Kansas (Lawrence, Kansas); The Children's Mercy Hospital (Kansas City, Missouri) |
| INVENTOR(S) | Michael Detamore (Lawrence, Kansas); Lindsey Ott (Lawrence, Kansas); Robert Weatherly (Overland Park, Kansas) |
| ABSTRACT | An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517027 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) A61F 2/20 (20130101) Original (OR) Class A61F 2002/046 (20130101) A61F 2210/0076 (20130101) A61F 2250/0018 (20130101) A61F 2250/0028 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/10 (20130101) A61L 27/14 (20130101) A61L 27/18 (20130101) A61L 27/34 (20130101) A61L 2300/414 (20130101) A61L 2420/04 (20130101) A61L 2420/08 (20130101) A61L 2430/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054662 | Pease et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonard F. Pease (Salt Lake City, Utah); Hedieh Saffari (Salt Lake City, Utah); Gerald J. Gleich (Salt Lake City, Utah); Kristin M. Leiferman (Salt Lake City, Utah); Kathryn A. Peterson (Salt Lake City, Utah); Russell Morris Condie (Salt Lake City, Utah) |
| ABSTRACT | Also disclosed are methods |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379402 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/08 (20130101) A61K 51/0491 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054704 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Ung-Jin Kim (Daejeon, South Korea); Jaehyung Park (Decatur, Georgia); Hyoung-Joon Jin (Seoul, South Korea) |
| ABSTRACT | The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466239 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/52 (20130101) A61L 27/56 (20130101) A61L 27/227 (20130101) Original (OR) Class A61L 27/3604 (20130101) A61L 2430/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 39/003 (20130101) B29C 39/203 (20130101) B29C 55/005 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 7/01 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/00 (20130101) Peptides C07K 14/43536 (20130101) C07K 14/43586 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/07 (20130101) C08J 3/075 (20130101) C08J 5/18 (20130101) C08J 9/26 (20130101) C08J 9/28 (20130101) C08J 9/0061 (20130101) C08J 2201/0444 (20130101) C08J 2201/0504 (20130101) C08J 2205/022 (20130101) C08J 2389/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249921 (20150401) Y10T 442/10 (20150401) Y10T 442/60 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054708 | Murphy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Murphy (Waunakee, Wisconsin); Gianluca Fontana (Madison, Wisconsin); Joshua Gershlak (Worcester, Massachusetts); Glenn Gaudette (Worcester, Massachusetts); Pam Weathers (Worcester, Massachusetts); Tanja Dominko (Worcester, Massachusetts); Marsha Rolle (Worchester, Massachusetts); Sarah Hernandez (San Juan Capistrano, California); Carol Cramer (State University, Arkansas); Fabricio Medina-Bolivar (State University, Arkansas) |
| ABSTRACT | Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388652 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) A61L 27/3637 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 2300/25 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/04 (20130101) C12N 5/0068 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055112 | Torabi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3DEO, Inc. (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Payman Torabi (Los Angeles, California); Matthew Petros (Los Angeles, California); Mahmood SHIROOYEH (Los Angeles, California) |
| ABSTRACT | The present disclosure provides systems and methods for the formation of three-dimensional objects. A method for forming a three-dimensional object may comprise alternately and sequentially applying a stream comprising a binding substance to an area of a layer of powder material in a powder bed, and generating at least one perimeter of the three-dimensional object in the area. The stream may be applied in accordance with a model design of the three-dimensional object. The at least one perimeter may generated in accordance with the model design. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234374 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/14 (20210101) Original (OR) Class Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055287 | Fernandez-Nieves et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alberto Fernandez-Nieves (Suwanee, Georgia); Thomas Eltor Angelini (Gainesville, Florida); Ya-Wen Chang (Alpharetta, Georgia); Samantha M. Marquez (New Haven, Connecticut) |
| ABSTRACT | A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519752 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/40 (20170801) B29C 64/106 (20170801) Original (OR) Class B29C 64/153 (20170801) B29C 64/209 (20170801) B29C 64/259 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2023/06 (20130101) B29K 2033/08 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055292 | GUIMBRETIERE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francois GUIMBRETIERE (Ithaca, New York); Huaishu PENG (Ithaca, New York); Stephen Robert MARSCHNER (Ithaca, New York); Rundong WU (Ithaca, New York) |
| ABSTRACT | Systems and methods are provided for incremental 3D printing, wherein wireframes are generated and printed (scheduled for print) during the design process. In another aspect, systems and methods are provided for printing arbitrary meshes. A 3D printer system is described having, for example, five degree-of-freedom (5DOF). The 5DOF printer may be used to perform any of the methods described herein and combinations of the methods. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516154 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/141 (20170801) Original (OR) Class B29C 64/314 (20170801) B29C 64/321 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Electric Digital Data Processing G06F 30/17 (20200101) Image Data Processing or Generation, in General G06T 17/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055947 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jialai Wang (Tuscaloosa, Alabama) |
| ABSTRACT | Cementitious compositions comprising a hydraulic cementitious material, a compound selected from the group consisting of a polyhydroxy aromatic compound, a polycarboxylic acid-containing compound or a salt thereof, ascorbic acid or a salt thereof, or a combination thereof, and a particulate material or a water soluble silicate-containing material that interacts with the compound are described herein. The polyhydroxy aromatic compound can be a water soluble compound having from two to thirty hydroxyl groups. The particulate material can exhibit a particle size distribution, wherein at least about 90% by weight of the particles have a diameter of less than 2 mm. Suitable particulate materials include nanoparticles and microparticles. The cementitious compositions can be used to form building materials. The cementitious compositions are especially suited for inhibiting corrosion of reinforcing steel bars embedded in concrete mixtures. Methods of making and using the cementitious composition are also disclosed. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390184 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/005 (20130101) C04B 24/02 (20130101) C04B 24/06 (20130101) Original (OR) Class C04B 28/04 (20130101) C04B 28/24 (20130101) C04B 28/26 (20130101) C04B 28/188 (20130101) C04B 40/0046 (20130101) C04B 2111/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056167 | Veige |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam S. Veige (Gainesville, Florida) |
| ABSTRACT | The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516191 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056200 | Niu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Niu (Lexington, Massachusetts); Hanchu Huang (Newton, Massachusetts); Wenqi Wang (Brighton, Massachusetts) |
| ABSTRACT | Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512055 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/12 (20130101) Original (OR) Class C08G 2261/11 (20130101) C08G 2261/122 (20130101) C08G 2261/126 (20130101) C08G 2261/164 (20130101) C08G 2261/418 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056290 | Youngblood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Paul Youngblood (Crawfordsville, Indiana); Reaz Chowdhury (West Lafayette, None); Md Nuruddin (West Lafayette, Indiana) |
| ABSTRACT | A method of large-scale continuous roll-to-roll fabrication of cellulose nanocrystal (CNC) coatings with controlled anisotropy, and CNC-coated flexible substrates prepared thereby. An order parameter of 0.78 is observed in CNC-poly(vinyl alcohol) (CNC-PVA) coating systems at 70% CNC loadings. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517354 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/14 (20130101) Original (OR) Class C09D 11/106 (20130101) C09D 101/02 (20130101) C09D 129/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056335 | Delcamp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Mississippi (University, Mississippi); Mississippi State University (Mississippi State, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared Delcamp (Oxford, Mississippi); Nathan Hammer (Oxford, Mississippi); Colleen Scott (Starkville, Mississippi) |
| ABSTRACT | In one aspect, the disclosure relates to fluorescent dyes that absorb and emit in the near infrared II (NIR II) range of the electromagnetic spectrum, methods of making same, compositions comprising same and methods of using the compositions to perform imaging on biological samples, and optoelectronic devices using the dyes. The dyes are small organic molecules that are inexpensive and facile to produce, can be water-soluble, have tunable properties, and are biocompatible and/or possess low toxicity. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407838 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 57/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056492 | Chu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Kung-Hui Chu (College Station, Texas); Ry Young (College Station, Texas); Jason Gill (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to an oleaginous bacterium. In some embodiments, the oleaginous bacterium includes lipids and at least one exogenous and inducible gene. In some embodiments, the exogenous and inducible gene encodes at least one protein capable of inducing lysis in the oleaginous bacterium to release the lipids. In an addition embodiment, the present disclosure pertains to a method of releasing lipids into an environment. In general, the method includes one or more of the following steps of: (1) introducing at least one oleaginous bacterium of the present disclosure to the environment; and (2) inducing expression of at least one exogenous gene in the oleaginous bacterium to thereby induce the expression of at least one protein. In some embodiments, the protein facilitates the lysis of the oleaginous bacterium and release of the lipids into the environment. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407939 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6463 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/365 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056495 | Siddiqui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Shareef Siddiqui (San Mateo, California); Christina D. Smolke (Menlo Park, California) |
| ABSTRACT | Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAs) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The host cells may have one or more engineered modifications selected from: a feedback inhibition alleviating mutation in a enzyme gene; a transcriptional modulation modification of a biosynthetic enzyme gene, an inactivating mutation in an enzyme; and a heterologous coding sequence. Also provided are methods of producing a BIA of interest or a precursor thereof using the host cells and compositions, e.g., kits, systems etc., that find use in methods of the invention. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386204 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0071 (20130101) C12N 9/90 (20130101) C12N 9/1085 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) C12P 13/001 (20130101) C12P 13/225 (20130101) C12P 17/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056498 | KISHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jocelyn KISHI (Boston, Massachusetts); Ninning LIU (Boston, Massachusetts); Sinem SAKA (Allston, Massachusetts); Peng YIN (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compositions, kits and methods for synthesis of nucleic acids. Also provided herein are compositions and methods for synthesizing strands of nucleic acid across different nucleic acid back-bones hybridized together using a strand displacing polymerase. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/415326 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056503 | Seelig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Georg Seelig (Seattle, Washington); Richard Muscat (London, United Kingdom); Alexander B. Rosenberg (Seattle, Washington) |
| ABSTRACT | Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521263 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056934 | Staack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Staack (College Station, Texas); Xin Tang (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a cavitation generation device that includes a dactyl plunger rotatable about an axis between an open position and a closed position and a propus socket having a channel. The propus socket is rigidly mounted below the dactyl plunger, and the dactyl plunger is received into the propus socket when the dactyl plunger is in the closed position. The cavitation generation device can also include a torsion spring that biases the dactyl plunger into contact with the propus socket. In another embodiment, the present disclosure pertains to a method of inducing a cavitation including biasing a dactyl plunger via a torsion spring, and rotating the dactyl plunger, by action of the torsion spring, into a propus socket. The propus socket includes a nozzle-shaped channel. The method further includes ejecting a socket cavity volume through the nozzle-shaped channel thereby inducing a cavitation event. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517996 |
| CURRENT CPC | Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057260 | DUMONT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emmanuel DUMONT (New York, New York); Peter KAPLAN (Montclair, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanuel DUMONT (New York, New York); Peter KAPLAN (Montclair, New Jersey) |
| ABSTRACT | Methods of accurately estimating erythemaly-weighted UV exposure, such as the UV Index, and sensors adapted for the same. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327361 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/16 (20130101) G01J 1/44 (20130101) G01J 1/429 (20130101) Original (OR) Class G01J 1/0488 (20130101) G01J 2001/444 (20130101) G01J 2001/1657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058077 | Stolfo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore J. Stolfo (Ridgewood, New Jersey); Angelos D. Keromytis (New York, New York); Stylianos Sidiroglou (Astoria, New York) |
| ABSTRACT | Methods, media, and systems for detecting anomalous program executions are provided. In some embodiments, methods for detecting anomalous program executions are provided, comprising: executing at least a part of a program in an emulator; comparing a function call made in the emulator to a model of function calls for the at least a part of the program; and identifying the function call as anomalous based on the comparison. In some embodiments, methods for detecting anomalous program executions are provided, comprising: modifying a program to include indicators of program-level function calls being made during execution of the program; comparing at least one of the indicators of program-level function calls made in the emulator to a model of function calls for the at least a part of the program; and identifying a function call corresponding to the at least one of the indicators as anomalous based on the comparison. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/202569 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) G06F 11/0718 (20130101) G06F 11/0751 (20130101) G06F 11/0772 (20130101) Original (OR) Class G06F 11/3652 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058315 | Yavari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Niger) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Yavari (Lincoln, Nebraska); Prahalada Krishna Rao (Lincoln, Nebraska); Kevin Cole (Lincoln, Nebraska) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for simulating heat transfer in additive manufacturing. Implementations disclosed herein convert a model of an object into a node representation of the object, and generate an adjacency matrix of the object based on the node representation. For each layer of nodes in the node representation, implementations apply a simulated heat to the layer of nodes, and estimating a diffusion of heat to other nodes based on the adjacency matrix. Implementations generate a representation of an estimated heat distribution within the object. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275735 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/23 (20200101) Original (OR) Class G06F 2113/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058369 | Alahmari et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida); STEREOLOGY RESOURCE CENTER, INC. (Saint Petersburg, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saeed S. Alahmari (Tampa, Florida); Dmitry Goldgof (Tampa, Florida); Lawrence O. Hall (Tampa, Florida); Peter R. Mouton (Tampa, Florida) |
| ABSTRACT | Systems and methods for automated stereology are provided. In some embodiments, an active deep learning approach may be utilized to allow for a faster and more efficient training of a deep learning model for stereology analysis. In other embodiments, existing deep learning models for stereology analysis may be re-tuned to develop greater accuracy for a given data set of interest, either with or without an active deep learning approach. A method can include: capturing a data set including a stack of images of a three-dimensional (3D) object; determining whether an existing deep learning model is appropriate for use on the stack of images (or for re-tuning); performing pre-processing on the data set; performing a training of a deep learning model; applying the deep learning model to obtain a confidence score for each label of the data set; reviewing, by a user, at least some labels in the active set to verify whether the label displays sufficient agreement with an expected result, and moving only those that display sufficient agreement to a training set; and performing a stereology analysis using the trained deep learning model. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397891 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/367 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/40 (20130101) G06K 9/00134 (20130101) Original (OR) Class G06K 9/00201 (20130101) G06K 9/342 (20130101) G06K 9/6227 (20130101) G06K 9/6256 (20130101) G06K 9/6263 (20130101) G06K 2209/05 (20130101) G06K 2209/27 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220058842 | KOTANI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Atsunobu KOTANI (Tokyo, Japan); Stefanie TELLEX (Providence, Rhode Island); James TOMPKIN (Cambridge, Massachusetts) |
| ABSTRACT | A method of representing a space of handwriting stroke styles includes representing writer-, character- and writer-character-level style variations within a recurrent neural network (RNN) model using decoupled style descriptors (DSD) that model the style variations such that character style variations depend on writer style. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409347 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 11/203 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059189 | Rosing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tajana Simunic Rosing (San Diego, California); Mohsen Imani (San Diego, California); Yeseong Kim (San Diego, California); Behnam Khaleghi (La Jolla, California); Alexander Niema Moshiri (San Diego, California); Saransh Gupta (La Jolla, California); Venkatesh Kumar (Sunnyvale, California) |
| ABSTRACT | A method of searching for a query sequence of nucleotide characters within a chromosomal or genomic nucleic acid reference sequence can include receiving a query sequence representing nucleotide characters to be searched for within a reference sequence of characters represented by a reference hypervector generated by combining respective base hypervectors for each nucleotide character included in the reference sequence of characters appearing in all sub-strings of characters having a length between a specified lower length and a specified upper length within the reference sequence, combining respective near orthogonal base hypervectors for each of the nucleotide characters included in the query sequence to generate a query hypervector, and generating a dot product of the query hypervector and the reference hypervector to determine a decision score indicating a degree to which the query sequence is included in the reference sequence. Other aspects and embodiments according to the invention are also disclosed herein. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376096 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9032 (20190101) G06F 16/90335 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 40/30 (20190201) Original (OR) Class G16B 50/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059332 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Evan R. Williams (Oakland, California); Conner C. Harper (Albany, California); Andrew G. Elliott (Berkeley, California) |
| ABSTRACT | Systems and multiplexing methods for measuring the mass of multiple large molecules simultaneously using multiple ion trapping with charge detection mass spectrometry (CDMS) are described. The methods trap ions with a broad range of energies that decouple ion frequency and m/z measurements allowing energy measurements of each ion throughout the acquisition. The ion energy may be obtained from the ratio of the intensity of the fundamental to the second harmonic frequencies of the periodic trapping oscillation making it possible to measure both the m/z and charge of each ion. Because ions with the exact same m/z but different energies appear at different frequencies, the probability of ion-ion interference is significantly reduced. By maximizing the decoupling of ion m/z from frequency, the rate of signal overlap is significantly reduced making it possible to trap more ions and substantially reduce analysis time. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465045 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) Original (OR) Class H01J 49/0031 (20130101) H01J 49/0036 (20130101) H01J 49/4245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059724 | RAJAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siddharth RAJAN (Columbus, Ohio); Yuewei ZHANG (Columbus, Ohio); Zane JAMAL-EDDINE (Columbus, Ohio); Fatih AKYOL (Corum/ Merkez, Turkey) |
| ABSTRACT | An example tunnel junction ultraviolet (UV) light emitting diode (LED) is described herein. The UV LED can include a mesa structure having at least one of: an n-doped bottom contact region, a p-doped region, and a tunnel junction arranged in contact with the p-doped region. Additionally, a geometry of the mesa structure can be configured to increase respective efficiencies of extracting transverse-electric (TE) polarized light and transverse-magnetic (TM) polarized light from the tunnel junction UV LED. The mesa structure can be configured such that an emitted photon travels less than 10 μm before reaching the inclined sidewall. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/516796 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) H01L 33/20 (20130101) Original (OR) Class H01L 33/32 (20130101) H01L 33/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059780 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALLIANCE FOR SUSTAINABLE ENERGY, LLC (Golden, Colorado); BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (DeKalb, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Jinhui TONG (Lakewood, Colorado); Tao XU (Naperville, Illinois); Xun LI (DeKalb, Illinois) |
| ABSTRACT | The present disclosure relates to a composition that includes a material of at least one of a perovskite structure, a perovskite-like structure, and/or a perovskitoid structure, where the material includes an isotope of an element, the isotope has more neutrons than protons, and the isotope is incorporated into the perovskite structure, the perovskite-like structure, and/or the perovskitoid structure. In some embodiments of the present disclosure, the isotope may make up between greater than 0% and 100% of the element. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406275 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0077 (20130101) Original (OR) Class H01L 51/4253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220060150 | Zorlutuna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana); University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pinar Zorlutuna (South Bend, Indiana); Suman Datta (South Bend, Indiana); Jorge Gomez Mir (Bouth Bend, Indiana); Xiang Ren (South Bend, Indiana); Nikhil Shrikant Shukla (Charlottesville, Virginia); Jiaying Ji (South Bend, Indiana); Mohammad Khairul Bashar (Charlottesville, Virginia) |
| ABSTRACT | A coupled bio-oscillating material is disclosed. The coupled bio-oscillating material comprises at least two cardiac muscle (CM) cell clusters and at least one cardiac fibroblast (CF) cell bridge on a substrate. The at least one CF cell bridge provides electrical conduction between the at least two CM cell clusters. The at least two CM cell clusters oscillate and synchronize at a unique phase ordering between the at least two CM cell clusters. The coupled bio-oscillating material can be used. The coupled bio-oscillating material can be used to create coupled bio-oscillator networks. A method of creating a coupled bio-oscillator network. The coupled bio-oscillator networks can be used for collective computing. A re-programmable bio-oscillatory network is also disclosed. The re-programmable bio-oscillatory network comprises a patterning layer, an enzyme channeling layer, and a pneumatic controlling layer. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407604 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/002 (20130101) Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 28/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220060668 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of HarvardCollege (Cambridge, Massachusetts); Massachusetts Institute ofTechnology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donggyu Kim (Cambridge, Massachusetts); Alexander Keesling Contreras (Boston, Massachusetts); Ahmed Omran (Somervill, Massachusetts); Harry Jay Levine (Cambridge, Massachusetts); Hannes Bernien (Somerville, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts); Dirk R. Englund (Cambridge, Massachusetts) |
| ABSTRACT | A method of generating uniform large-scale optical focus arrays (LOT As) with a phase spatial light modulator includes identifying and removing undesired phase rotation in the iterative Fourier transform algorithm (IFTA), thereby producing computer-generated holograms of highly uniform LOT As using a reduced number of iterations as compared to a weighted Gerch-berg-Saxton algorithm. The method also enables a faster compensation of optical system-induced LOT A intensity inhomogeneity than the conventional IFTA. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432723 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 9/317 (20130101) H04N 9/3102 (20130101) H04N 9/3138 (20130101) Original (OR) Class H04N 9/3197 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220055133 | Nicholas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan); DELPHI TECHNOLOGIES, LLC (Troy, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Dale Nicholas (Okemos, Michigan); Quan Zhou (Farmington Hills, Michigan); Thomas Rector Bieler (East Lansing, Michigan); Rick Daniel Kerr (Fenton, Michigan) |
| ABSTRACT | The disclosure relates to a brazing method for joining substrates, in particular where one of the substrates is difficult to wet with molten braze material. The method includes formation of a porous metal layer on a first substrate to assist wetting of the first substrate with a molten braze metal, which in turn permits joining of the first substrate with a second substrate via a braze metal later in an assembled brazed joint. Ceramic substrates can be particularly difficult to wet with molten braze metals, and the disclosed method can be used to join a ceramic substrate to another substrate. The brazed joint can be incorporated into a solid-oxide fuel cell, for example as a stack component thereof, in particular when the first substrate is a ceramic substrate and the joined substrate is a metallic substrate. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518734 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/008 (20130101) B23K 1/0016 (20130101) Original (OR) Class B23K 1/19 (20130101) B23K 1/20 (20130101) B23K 2101/36 (20180801) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0232 (20130101) H01M 8/0236 (20130101) H01M 8/0245 (20130101) H01M 8/0282 (20130101) H01M 8/1246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055188 | Anderson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Kris A. Anderson (Lockport, Illinois) |
| ABSTRACT | A centerline clamp assembly sized to insert into an end aperture of a pipe structure, characterized by two or more symmetrically-formed linkages interoperably connected in series, with each of these linkages comprising respective opposing toggle joints pivotally joined at their inner ends to a shared common linkage assembly and at their outer ends by a respective first linkage assembly and a second linkage assembly, with each linkage assembly defining a respective bore configured to concurrently receive an actuating shaft in position along a common geometric centerline axis of the pipe. Multiple alternative configurations may be used in which the number of linkages and linkage assemblies may be increased to achieve clamping action at multiple locations in a pipe structure, thus varying the clamping force according to the properties of the pipe. The configuration and number of linkage assemblies may serve as mounting platforms for instruments, tools, and/or accessories. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390231 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 5/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055303 | CRATON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Michael Thomas CRATON (Lansing, Michigan); Ioannis PAPAPOLYMEROU (Okemos, Michigan); Premjeet CHAHAL (Okemos, Michigan); John D. ALBRECHT (Okemos, Michigan) |
| ABSTRACT | Material mixing for an additive manufacturing apparatus is provided. A further aspect employs multiple material inlets for simultaneously feeding a polymer and/or nanocomposite material in at least a first inlet, and ceramic or other particles in at least a second inlet, to a single additive manufacturing outlet nozzle. In another aspect, a three dimensional printing machine varies a chemical or compounding characteristic, such as a loading percentage, of printing material during printing. In another aspect, in situ mixing of a polymer and/or nanocomposite with variable amounts of ceramic, magnetic or other particles therein in an additive manufacturing apparatus, such as a multi-material aerosol jet printing machine. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388418 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 64/314 (20170801) Original (OR) Class B29C 64/393 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2509/02 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055308 | Schroeder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Haier US Appliance Solutions, Inc. (Wilmington, Delaware); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Goodman Schroeder (Louisville, Kentucky); Amelia McDow Elliott (Knoxville, Tennessee); Ayyoub Mehdizadeh Momen (Knoxville, Tennessee) |
| ABSTRACT | A method for additively manufacturing a microstructure from a caloric material includes providing a geometry of the microstructure to a processor of an additive manufacturing device, the geometry defining a plurality of microfeatures of the microstructure. The method also includes generating, via the processor, a three-dimensional (3D) model representative of the geometry of the microstructure, wherein one or more of the plurality of microfeatures are represented in the 3D model by a non-arcuate profile. Further, the method includes printing, via the additive manufacturing device, the microstructure from the caloric material according to the 3D model. As such, the non-arcuate profile reduces a file size of the 3D model as compared to an arcuate profile. |
| FILED | Tuesday, August 18, 2020 |
| APPL NO | 16/996273 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055356 | Stadermann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Stadermann (Pleasanton, California); Patrick Campbell (Oakland, California); Philip E. Miller (Livermore, California); Chantel Aracne-Ruddle (Livermore, California); Sung Ho Kim (Livermore, California); Francisco J. Espinosa-Loza (Bellevue, Washington) |
| ABSTRACT | A process includes layering a graphene layer onto a polymer layer to form a composite film. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518410 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/005 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/007 (20130101) B32B 18/00 (20130101) B32B 27/06 (20130101) Original (OR) Class B32B 37/14 (20130101) B32B 2309/105 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) C01B 32/194 (20170801) Technical Subjects Covered by Former US Classification Y10T 428/30 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056082 | GRUVER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PIONEER HI-BRED INTERNATIONAL, INC. (JOHNSTON, Iowa) |
| ASSIGNEE(S) | PIONEER HI-BRED INTERNATIONAL, INC. (JOHNSTON, Iowa) |
| INVENTOR(S) | STEVEN D GRUVER (PACIFICA, California); HEATHER KOZY (WALNUT CREEK, California); JESSICA O'REAR (REDWOOD CITY, California); BARBARA ROSEN (MOUNTAIN VIEW, California); UTE SCHELLENBERGER (PALO ALTO, California); JUN-ZHI WEI (JOHNSTON, Iowa); WEIPING XIE (EAST PALO ALTO, California); XIAOHONG ZHONG (SAN LEANDRO, California); GENHAI ZHU (SAN JOSE, California) |
| ABSTRACT | Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/453439 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/46 (20130101) A01N 63/50 (20200101) Peptides C07K 14/21 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8286 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056215 | Rios et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Orlando Rios (Knoxville, Tennessee); William G. Carter (Knoxville, Tennessee); Michael R. Kessler (Fargo, North Dakota); Yuzhan Li (Knoxville, Tennessee); Monojoy Goswami (Knoxville, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (, None); North Dakota State University (, None) |
| INVENTOR(S) | Orlando Rios (Knoxville, Tennessee); William G. Carter (Knoxville, Tennessee); Michael R. Kessler (Fargo, North Dakota); Yuzhan Li (Knoxville, Tennessee); Monojoy Goswami (Knoxville, Tennessee) |
| ABSTRACT | Disclosed herein are embodiments of a composition that can be used to make liquid crystalline networks using thiol-ene-based polymerization. In particular embodiments, the liquid crystalline networks can be formed by using the composition embodiments in additive manufacturing methods. The composition comprises a monomer, chain extender compound, and a crosslinker compound and each of these components can be selected so as to influence the thermomechanical and shape memory properties of the liquid crystalline networks and/or objects formed therewith. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076693 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) B29C 64/336 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2025/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 75/045 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/3804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056305 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | C. Garrett Campbell (Albuquerque, New Mexico); Mathias C. Celina (Albuquerque, New Mexico) |
| ABSTRACT | The invention is directed to a method of controlled conversion of thermosetting resins and additive manufacturing thereof by selective laser sintering. Partial curing of a thermosetting formulation can be used to increase the Tg of the resin and minimize the additional cure needed to cross-link a printed object. After printing, the partially cured material is finally cured via a slow temperature ramp maintained just below the material's evolving Tg. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400417 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/223 (20130101) C08G 59/245 (20130101) C08G 59/504 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 163/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056333 | CANNAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARBO CERAMICS INC. (Houston, Texas); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad CANNAN (Lancaster, New York); Lewis BARTEL (Albuquerque, New Mexico); Terrence PALISCH (Richardson, Texas); David ALDRIDGE (Albuquerque, New Mexico) |
| ABSTRACT | Electrically conductive proppants and methods for detecting, locating, and characterizing same are provided. The electrically conductive proppant can include a substantially uniform coating of an electrically conductive material having a thickness of at least 500 nm. The method can include injecting a hydraulic fluid into a wellbore extending into a subterranean formation at a rate and pressure sufficient to open a fracture therein, injecting into the fracture a fluid containing the electrically conductive proppant, electrically energizing the earth at or near the fracture, and measuring three dimensional (x, y, and z) components of electric and magnetic field responses at a surface of the earth or in an adjacent wellbore. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517503 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/805 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/06 (20130101) C23C 14/35 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/25 (20130101) E21B 43/26 (20130101) E21B 43/267 (20130101) E21B 47/00 (20130101) E21B 47/092 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056596 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meng Li (Ammon, Idaho); Bin Hua (Ammon, Idaho); Dong Ding (Idaho Falls, Idaho) |
| ABSTRACT | A method of hydrogenating carbon dioxide comprises forming a tunable catalyst comprising at least one metal comprising a size within a range of from a single atom to about 999 nanometers and formulated to produce one or more carbon-containing compound. An electrochemical cell comprising a positive electrode, a negative electrode comprising the tunable catalyst, and an electrolyte between the positive electrode and the negative electrode is formed. Carbon dioxide is introduced to the negative electrode of the electrochemical cell and a potential difference is applied between the positive electrode and the negative electrode to selectively hydrogenate the carbon dioxide. The hydrogen ions are diffused through the electrochemical cell. The carbon dioxide at the negative electrode is hydrogenated to selectively form carbon monoxide, methane, or a desired ratio of carbon monoxide and methane. An electrochemical cell and a carbon dioxide hydrogenation system are also disclosed. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/445685 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 1/50 (20210101) C25B 3/03 (20210101) C25B 3/26 (20210101) Original (OR) Class C25B 9/17 (20210101) C25B 11/052 (20210101) C25B 11/069 (20210101) C25B 11/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056601 | Gregoire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M Gregoire (Sierra Madre, California); Lan Zhou (Pasadena, California); Santosh K. Suram (Pasadena, California); Aniketa A. Shinde (Duarte, California); Joel A. Haber (Pasadena, California); Dan W. Guevarra (Norwalk, California) |
| ABSTRACT | An oxygen evolution reaction catalyst is a ternary metal oxide that includes Mn and is represented by MnuSbvOw in the rutile crystal phase and MxMnyOz where M is selected from the group consisting of Ca, Ni, Sr, Zn, Mg, Ni, Ba, Co and where u/(u+v) is greater than 33%. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328422 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4672 (20130101) C02F 1/46109 (20130101) C02F 2001/46142 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/55 (20210101) C25B 11/077 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056854 | ROBEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Wade James ROBEL (Dunlap, Illinois); Spencer Landon HUHN (Chillicothe, Illinois); Kevin WEISS (Peoria, Illinois); John Robert McDONALD (Peoria, Illinois); Jason Kenneth BLOMS (Edwards, Illinois) |
| ABSTRACT | A controller may identify an indication to initiate an engine braking procedure associated with an engine of a machine. The controller may obtain, based on identifying the indication to initiate the engine braking procedure, information relating to a requested amount of engine braking power of the engine. The controller may cause one or more components of a variable geometry turbocharger (VGT) of the engine to adjust, and a throttle valve of the engine to adjust, based on the information relating to the requested amount of engine braking power of the engine. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/947826 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 37/24 (20130101) Controlling Combustion Engines F02D 9/02 (20130101) Original (OR) Class F02D 41/0005 (20130101) F02D 41/0007 (20130101) F02D 41/1446 (20130101) F02D 2009/0222 (20130101) F02D 2009/0242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057119 | Holladay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battlelle Memorial Institute (Richland, Washington); Emerald Energy NW, LLC (Bothell, Washington) |
| ASSIGNEE(S) | Battlelle Memorial Institute (Richland, Washington); Emerald Energy NW, LLC (Bothell, Washington) |
| INVENTOR(S) | Jamie D. Holladay (Richland, Washington); Kerry D. Meinhardt (Kennewick, Washington); Evgueni Polikarpov (Richland, Washington); Edwin C. Thomsen (Richland, Washington); John Barclay (Richland, Washington) |
| ABSTRACT | A process for liquefying a process gas that includes introducing a heat transfer fluid into an active magnetic regenerative refrigerator apparatus that comprises a single stage comprising dual multilayer regenerators located axially opposite to each other. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517150 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/00 (20130101) Original (OR) Class F25B 2321/0021 (20130101) F25B 2321/0022 (20130101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 11/02 (20130101) Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 1/001 (20130101) F25J 2270/908 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/0275 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/012 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 37/04 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057202 | Kreitinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bridger Photonics, Inc. (Bozeman, Montana) |
| ASSIGNEE(S) | Bridger Photonics, Inc. (Bozeman, Montana) |
| INVENTOR(S) | Aaron Thomas Kreitinger (Bozeman, Montana); Michael James Thorpe (Bozeman, Montana) |
| ABSTRACT | Measurement apparatuses and methods are disclosed for generating high-precision and—accuracy gas concentration maps that can be overlaid with 3D topographic images by rapidly scanning one or several modulated laser beams with a spatially-encoded transmitter over a scene to build-up imagery. Independent measurements of the topographic target distance and path-integrated gas concentration are combined to yield a map of the path-averaged concentration between the sensor and each point in the image. This type of image is particularly useful for finding localized regions of elevated (or anomalous) gas concentration making it ideal for large-area leak detection and quantification applications including: oil and gas pipeline monitoring, chemical processing facility monitoring, and environmental monitoring. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399106 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/20 (20130101) Original (OR) Class Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 15/00 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/28 (20130101) G01M 3/38 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/53 (20130101) G01N 2021/1793 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057368 | REMILLIEUX et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chevron U.S.A. Inc. (San Ramon, California); Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcel REMILLIEUX (Los Alamos, New Mexico); Esteban ROUGIER (Los Alamos, New Mexico); Zhou LEI (Los Alamos, New Mexico); Timothy James ULRICH (Los Alamos, New Mexico); Harvey Edwin GOODMAN (San Ramon, California) |
| ABSTRACT | Structure information for a substance within a volume may be obtained. The structure information may characterize structural non-linearity of the substance within the volume. A structure model for the substance within the volume may be generated based on the structure information and/or other information. The structure model may simulate one or more characteristics of the substance within the volume. Presentation of information on the characteristic(s) of the substance within the volume may be effectuated based on the structure model and/or other information. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 17/602242 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/12 (20130101) Original (OR) Class G01N 29/4472 (20130101) G01N 2291/0232 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057551 | Hiszpanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna M. Hiszpanski (Livermore, California); Joshua D. Kuntz (Livermore, California); Eric Meshot (Livermore, California); Kerry G. Krauter (Livermore, California); Elaine Lee (Livermore, California); Andrew J. Pascall (Livermore, California); Marcus A. Worsley (Livermore, California) |
| ABSTRACT | Directionally dependent optical effects are produced from faceted micrometer-scale substructures. The directionally dependent optical effects can appear as one specific color when viewed from one direction and another specific color when flipped and viewed from the opposing direction. The directionally dependent optical effects may appear reflective or transmissive from one direction and antireflective or opaque when flipped around. |
| FILED | Friday, December 14, 2018 |
| APPL NO | 17/413443 |
| CURRENT CPC | Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/324 (20141001) B42D 25/351 (20141001) B42D 25/373 (20141001) Optical Elements, Systems, or Apparatus G02B 5/09 (20130101) G02B 5/136 (20130101) G02B 5/1861 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059246 | Crawford |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony L. Crawford (Rigby, Idaho) |
| ABSTRACT | A control drum assembly may include a control drum and a control assembly coupled to the control drum through a drive shaft. The control drum assembly may also include a cage assembly. The cage assembly may include one or more structural supports and one or more modular platforms coupled to the one or more structural supports. The one or more modular platforms may be configured to support one or more components of the control assembly. The cage assembly may also include a base configured to be coupled to a surface of a core and to locate the cage assembly relative to the core. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399894 |
| CURRENT CPC | Nuclear Reactors G21C 7/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059247 | Crawford |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony L. Crawford (Rigby, Idaho) |
| ABSTRACT | A control rod drive system includes a drive assembly and a cage assembly operably coupled to the drive assembly. The cage assembly includes a plurality of drive rods operably engaged with a drive platform, a plurality of guide rods extending through the drive platform, and a control platform releasably coupled to the drive platform via quick release assembly, the control platform configured to have a control rod mounted thereto. A method of control operation of a nuclear reactor includes receiving instructions to adjust operation of the nuclear reactor, moving a control rod relative to a core of the nuclear reactor via rotating one or more drive rods engaged with a drive platform, and releasing a control platform coupled to the control rod from the drive platform. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399910 |
| CURRENT CPC | Nuclear Reactors G21C 7/14 (20130101) Original (OR) Class G21C 7/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059272 | Ramabhadran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GE AVIATION SYSTEMS LLC (Grand Rapids, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramanujam Ramabhadran (Jericho, New York); Ruxi Wang (Cohoes, New York); Juan Manuel Rivas Davila (Palo Alto, California); Jiale Xu (Sunnyvale, California) |
| ABSTRACT | A component includes a magnetic core having a body formed of a first material, defining a first opening and a second opening thereon. A duct formed of a second material extends at least partially through the body between the first opening and the second opening. The first opening and the second opening are in fluid communication by way of the duct. |
| FILED | Monday, August 24, 2020 |
| APPL NO | 17/001171 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 2101/42 (20180801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/08 (20130101) Original (OR) Class H01F 27/245 (20130101) H01F 41/0233 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/181 (20130101) H05K 3/341 (20130101) H05K 2201/1003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059780 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALLIANCE FOR SUSTAINABLE ENERGY, LLC (Golden, Colorado); BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (DeKalb, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Jinhui TONG (Lakewood, Colorado); Tao XU (Naperville, Illinois); Xun LI (DeKalb, Illinois) |
| ABSTRACT | The present disclosure relates to a composition that includes a material of at least one of a perovskite structure, a perovskite-like structure, and/or a perovskitoid structure, where the material includes an isotope of an element, the isotope has more neutrons than protons, and the isotope is incorporated into the perovskite structure, the perovskite-like structure, and/or the perovskitoid structure. In some embodiments of the present disclosure, the isotope may make up between greater than 0% and 100% of the element. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406275 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0003 (20130101) H01L 51/0077 (20130101) Original (OR) Class H01L 51/4253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059819 | Wong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation For The State University (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanislaus Wong (Upton, New York); Lei Wang (Port Jefferson, New York); Coray McBean (Malverne, New York); Amy C. Marschilok (Stony Brook, New York); Kenneth Takeuchi (Stony Brook, New York); Esther S. Takeuchi (Stony Brook, New York) |
| ABSTRACT | A method of fabricating nanocomposite anode material embodying a lithium titanate (LTO)-multi-walled carbon nanotube (MWNT) composite intended for use in a lithium-ion battery includes providing multi-walled carbon nanotube (MWNTs), including nanotube surfaces, onto which functional oxygenated carboxylic acid moieties are arranged, generating 3D flower-like, lithium titanate (LTO) microspheres, including thin nanosheets and anchoring the acid-functionalized MWNTs onto surfaces of the 3D LTO microspheres by π-π interaction strategy to realize the nanocomposite anode material. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/368252 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/364 (20130101) Original (OR) Class H01M 4/366 (20130101) H01M 4/485 (20130101) H01M 4/523 (20130101) H01M 4/587 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059842 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengcheng Zhang (Naperville, Illinois); Sisi Jiang (Willowbrook, Illinois) |
| ABSTRACT | A composition includes a silicon nanoparticle having surface-attached groups, and the silicon nanoparticle is represented by the formula: [Si]-[linker]-[terminal group]. In the formula [Si] represents the surface of the silicon nanoparticle; [terminal group] is a moiety that is configured for further reaction or is compatible with the electrolyte; and [linker] is a group linking the surface of the silicon nanoparticle to the [terminal group]. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 16/847952 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/137 (20130101) H01M 4/604 (20130101) Original (OR) Class H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059860 | Sankarasubramanian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shrihari Sankarasubramanian (St. Louis, Missouri); Vijay K. Ramani (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein is a redox flow battery (RFB). The battery generally includes: a positive electrolyte that is a first metal ion, a negative electrolyte that is a second metal ion, an ion exchange membrane positioned between the positive electrolyte and the negative electrolyte. The membrane is configured to restrict and/or prevent the passage of the first metal ion and/or the second metal ion therethrough, and is configured to maintain ionic conductivity between the positive electrolyte and the negative electrolyte. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/521046 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/083 (20130101) H01M 8/188 (20130101) Original (OR) Class H01M 8/0482 (20130101) H01M 8/1004 (20130101) H01M 2300/0011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220059861 | Fujimoto et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cy Fujimoto (Albuquerque, New Mexico); Ehren Baca (Albuquerque, New Mexico) |
| ABSTRACT | A fluoro sulfonated poly(phenylene) was rationally designed with an external hydrophobic shell and internal hydrophilic core in order to improve the durability and ion selectivity of a hydrocarbon membrane for vanadium redox flow batteries (VRFBs). The polymer was designed to prevent hydrophilic polymer chain aggregation by attaching acid moieties onto the polymer backbone, while functionalizing the external polymer shell with hydrophobic side chains to prevent excessive vanadium crossover associated with cation exchange membranes. As an example, the hydrophobic shell can be provided by pentafluorobenzoyl group functionalization of the pendent aryl groups on a Diels Alder poly(phenylene) backbone, while the internal polymer chain can contain sulfonic acid moieties to impart hydrophilic character. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391508 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) Original (OR) Class H01M 8/1004 (20130101) H01M 2300/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220060102 | Mazumder et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sudip K. Mazumder (Chicago, Illinois); Moien Mohamadi (Sanandaj, Iran); Nikhil Kumar (New Delhi, India) |
| ABSTRACT | A system for charging a battery includes three sub-modules, each receiving a respective phase of a three-phase alternating current (AC) signal. The three sub-modules cooperate to transform the respective phases of the three-phase AC signal to a direct current (DC) signal by passing the respective phases of the three-phase AC signal through a respective semiconductor device configured to discontinuously modulate the respective phase of the three-phase AC signal to convert it to a DC signal provided to the battery to charge the battery. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/264110 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/32 (20130101) Original (OR) Class H02M 3/005 (20130101) H02M 3/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220061145 | Timpson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Erik Joseph Timpson (Olathe, Kansas); Joseph Ambrose Wolf (Olathe, Kansas) |
| ABSTRACT | A system for creating a plasma field Faraday cage around a structure, the system comprising a plurality of lasers spaced apart from each other, each laser being configured to transmit an electromagnetic energy beam to a focal point of an atmosphere region, each electromagnetic energy beam having an amount of energy less than an amount of energy required to ionize air, the electromagnetic energy beams intersecting at the focal point such that the electromagnetic energy beams cooperatively ionize the air at the focal point to block electromagnetic radiation from passing through the focal point. |
| FILED | Monday, August 24, 2020 |
| APPL NO | 17/001112 |
| CURRENT CPC | X-ray Technique H05G 2/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220054318 | Schwenk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Giner Life Sciences, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa N. Schwenk (Somerville, Massachusetts); Ernesto Victor Ruiz (Wharton, New Jersey); Simon G. Stone (Arlington, Massachusetts); Linda A. Tempelman (Lincoln, Massachusetts) |
| ABSTRACT | System and method for modification of fluid environment of an ear. In one embodiment, the system includes an earpiece mountable within an ear canal. The earpiece includes a fluid delivery path for fluid to be delivered to the ear and a fluid removal path for fluid to be removed from the ear. The system also includes an electronics housing. The electronics housing may be directly mounted on the earpiece or positioned outside the ear. The system further includes an electrochemical gas generating device positioned within the electronics housing. In use, oxygen or the like is generated by the electrochemical gas generating device and is conveyed through the fluid delivery path of the earpiece, emerging from the earpiece distal end. The gas released from the earpiece causes fluid in the ear to be swept into the fluid removal path of the earpiece and eventually expelled to the outside of the ear. |
| FILED | Saturday, August 21, 2021 |
| APPL NO | 17/408396 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 11/006 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 13/003 (20130101) A61M 31/00 (20130101) A61M 2202/0208 (20130101) A61M 2205/502 (20130101) A61M 2205/8206 (20130101) A61M 2210/0662 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220054479 | JENKINS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elysium Therapeutics, Inc. (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. JENKINS (Half Moon Bay, California) |
| ABSTRACT | The invention provides pharmaceutical compositions comprising macromolecular gastrointestinal enzyme-labile opioid prodrugs, co-formulated with small-molecule and/or macromolecular gastrointestinal enzyme inhibitors. The macromolecular constructs are minimally absorbed from the GI tract, and can produce non-linear pharmacokinetic profiles of the delivered opioid agonist following oral ingestion. An optional macromolecular opioid antagonist may also be present in compositions of the invention to discourage tampering by potential abusers. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/475224 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/55 (20170801) A61K 47/61 (20170801) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055159 | Takata et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. Takata (Denver, Colorado); Loren Daniel Bridgers (Golden, Colorado); Eric D. Smith (Denver, Colorado); Eric Rubio (Denver, Colorado) |
| ABSTRACT | Devices, systems, and methods are directed to automated techniques for fitting flanges to tubular sections used to form tubular structures, such as large-scale structures used in industrial applications (e.g., wind towers and pipelines). As compared to manual techniques for fitting flanges to tubular sections, the devices, systems, and methods of the present disclosure facilitate faster attachment of flanges, which may be useful for achieving cost-effective throughput. By way of further comparison to manual techniques, the devices, systems, and methods of the present disclosure may, further or instead, facilitate achieving tighter dimensional tolerances. In turn, such tighter dimensional tolerances may be useful for forming thinner-walled, lighter, and lower cost tubular structures. Still further or in the alternative, automated techniques for fitting flanges to tubular sections may facilitate attachment of multipiece flanges or other non-traditional flange geometries. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517819 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/02 (20130101) B23K 37/003 (20130101) B23K 37/04 (20130101) Original (OR) Class B23K 37/047 (20130101) B23K 37/0536 (20130101) B23K 37/0538 (20130101) B23K 2101/06 (20180801) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 23/12 (20130101) F16L 23/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056152 | GARCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AQUALUNG THERAPEUTICS (TUCSON, Arizona) |
| ASSIGNEE(S) | AQUALUNG THERAPEUTICS (TUCSON, Arizona) |
| INVENTOR(S) | JOE G.N. GARCIA (TUCSON, Arizona); DARRAGH MACCANN (CO. DERRY, Ireland) |
| ABSTRACT | Anti-nicotinamide phosphoribosyltransferase (NAMPT) antibodies, or antigen binding fragments thereof, are described, as well as methods for treating a subject having a (NAMPT)-associated local and/or systemic inflammatory disorder. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 31/14 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056218 | Hancock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| ASSIGNEE(S) | Akita Innovations LLC (Billerica, Massachusetts) |
| INVENTOR(S) | Lawrence F. Hancock (North Andover, Massachusetts); Richard A. Minns (Arlington, Massachusetts) |
| ABSTRACT | Articles and methods related to the manufacture of polymers containing labile crosslinking moieties are generally described. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/997837 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220053738 | Abban et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel K. Abban (Laurel, Maryland); Irving Smith (Glenleg, Maryland); Francisco Posada-Florez (Laurel, Maryland) |
| ABSTRACT | The bee washing system washes worker bees and filters out varroa mites so that a beekeeper/operator can estimate the number of infected bees in a hive. The system includes a bee containment section with a coarse mesh filter, and a wash material section with a fine mesh filter. The system is structured so that when the bee containment section is loaded with bees, and the wash material section is loaded with wash material, an operator washes the bees by shaking the system. When the wash is complete, the operator detaches the wash material section from the system and counts the mites present on the fine mesh filter. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 16/999161 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 13/001 (20130101) A01K 51/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220053773 | GUPTA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Innate Immunity LLC (Santa Fe, New Mexico); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | Innate Immunity LLC (Santa Fe, New Mexico); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| INVENTOR(S) | Goutam GUPTA (Santa Fe, New Mexico); Eddie W. STOVER (Fort Pierce, Florida) |
| ABSTRACT | Disclosed herein are engineered antimicrobial peptides (e.g, HTH peptide or AAPs) and methods of using such peptides to treat pathogenic infections, such as HLB disease and X. fastidiosa, in plants, such as citrus plants and grape plants. The engineered antimicrobial peptides may be derived from amphipathic helical peptides. The engineered antimicrobial peptides disclosed herein may be formed by coupling two or more amphipathic helical peptides. An engineered antimicrobial peptide may include a first amphipathic helical peptide coupled with a second amphipathic helical peptide by a linker domain forming a helix-turn-helix scaffold formation. Such amphipathic helical peptides may be endogenous to a target host, such as a plant (e.g., a citrus plant or grape plant). |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281884 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Original (OR) Class Peptides C07K 14/415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055159 | Takata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. Takata (Denver, Colorado); Loren Daniel Bridgers (Golden, Colorado); Eric D. Smith (Denver, Colorado); Eric Rubio (Denver, Colorado) |
| ABSTRACT | Devices, systems, and methods are directed to automated techniques for fitting flanges to tubular sections used to form tubular structures, such as large-scale structures used in industrial applications (e.g., wind towers and pipelines). As compared to manual techniques for fitting flanges to tubular sections, the devices, systems, and methods of the present disclosure facilitate faster attachment of flanges, which may be useful for achieving cost-effective throughput. By way of further comparison to manual techniques, the devices, systems, and methods of the present disclosure may, further or instead, facilitate achieving tighter dimensional tolerances. In turn, such tighter dimensional tolerances may be useful for forming thinner-walled, lighter, and lower cost tubular structures. Still further or in the alternative, automated techniques for fitting flanges to tubular sections may facilitate attachment of multipiece flanges or other non-traditional flange geometries. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517819 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 31/02 (20130101) B23K 37/003 (20130101) B23K 37/04 (20130101) Original (OR) Class B23K 37/047 (20130101) B23K 37/0536 (20130101) B23K 37/0538 (20130101) B23K 2101/06 (20180801) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 23/12 (20130101) F16L 23/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220054622 | Puckette |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Puckette (Waterford, Connecticut) |
| ABSTRACT | A method of producing purified FMDV VLPs, comprising contacting cells containing FMDV VLPs with a lysis buffer and allowing the cells to lyse, the lysis buffer comprising 10-20 mM Tris-HCl, 150-200 mM NaCl, 3 mM MgCl2, and 1% Triton X-100, wherein the lysis buffer does not contain EDTA; centrifuging a solution; and removing a supernatant from the solution, the supernatant containing the purified FMDV VLPs. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519318 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/135 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/32123 (20130101) C12N 2770/32134 (20130101) C12N 2770/32151 (20130101) C12N 2770/32171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220055165 | Midyette et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Midyette (Elizabeth City, North Carolina); Craig Deen (Elizabeth City, North Carolina); Harlon Parchment (Elizabeth City, North Carolina) |
| ABSTRACT | In one example, an on-wing method for in-situ cutting on a wing-to-fuselage attachment includes attaching a first mount plate having a first linear bearing to provide movement in a first linear direction relative to the first mount plate, attaching a second mount plate having a second linear bearing to provide movement in a second linear direction relative to the second mount plate, attaching a tool mounting member to the second linear bearing to move with the second linear bearing, attaching a cutter to the tool mounting member to be adjustable relative to the second linear bearing, adjusting a depth position of a cut to be made on the wing-to-fuselage attachment, adjusting a width position of the cut, and moving the tool along a length direction of the cut to make the cut on the wing-to-fuselage attachment along the length direction at the adjusted depth position and the adjusted width position. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323100 |
| CURRENT CPC | Milling B23C 3/10 (20130101) B23C 3/36 (20130101) B23C 2215/04 (20130101) Details, Components, or Accessories for Machine Tools, e.g Arrangements for Copying or Controlling; Machine Tools in General Characterised by the Construction of Particular Details or Components; Combinations or Associations of Metal-working Machines, Not Directed to a Particular Result B23Q 9/0007 (20130101) Original (OR) Class B23Q 9/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057299 | DiCicco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Joseph DiCicco (Cape May Court House, New Jersey); Paul Flanigan (Marlton, New Jersey); Joshua Stroker (Somers Point, New Jersey); James Deline (Egg Harbor City, New Jersey) |
| ABSTRACT | An alignment tool has a body with a top cavity. The top cavity is open on a top side and configured to receive the dispenser housing of a dispenser or a sampling medium head of a sampling medium on which to place the dispenser housing. The sampling medium head has a sample collection area. The body has a bottom cavity configured to receive a hammer arm. The body has one or more sampling media cavities disposed between the top cavity and the bottom cavity, each configured to receive another sampling medium having a respective sample collection area. A barrier is disposed between the bottom cavity and other cavities including the top cavity and the one or more sampling media cavities. The top cavity and the one or more sampling media cavities are in communication with each other via a common slot extending from the top cavity to the barrier. The top cavity and the one or more sampling media cavities are configured to receive a plurality of different sampling media and to align the dispenser housing with the sample collection area of each of the different sampling media. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370746 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) Original (OR) Class G01N 2001/022 (20130101) G01N 2001/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220055114 | Hofmann et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Douglas C. Hofmann (Altadena, California); Andre M. Pate (Pasadena, California) |
| ABSTRACT | Methods for the fabrication of metal strain wave gear flexsplines using a specialized metal additive manufacturing technique are provided. The method allows the entire flexspline to be metal printed, including all the components: the output surface with mating features, the thin wall of the cup, and the teeth integral to the flexspline. The flexspline may be used directly upon removal from the building tray. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/453819 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 5/08 (20130101) B22F 10/20 (20210101) Original (OR) Class Making Gears or Toothed Racks B23F 5/163 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/04 (20130101) B23K 15/0086 (20130101) B23K 26/34 (20130101) B23K 26/354 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Gearing F16H 49/001 (20130101) F16H 55/06 (20130101) F16H 2049/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056211 | Wohl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Wohl (Chesapeake, Virginia); Bryce L. Horvath (Virginia Beach, Virginia); Sidney Eichelberger (Dallas, Texas); Nasef A. Junaid (Madison, Alabama) |
| ABSTRACT | Described herein are copoly(carbonate urethanes) with tunable properties. The copoly(carbonate urethanes) are produced from the reaction between an aryl diamine and an oligomer. By varying the molecular weight of the oligomer, the mechanical and thermal properties of the copoly(carbonate urethanes) can be modified (i.e., tuned). The copoly(carbonate urethanes) can be used to produce filaments for 3D printing applications that could have tunable properties for a variety of applications. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405611 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 71/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220057018 | Alexeenko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Alina Alexeenko (West Lafayette, Indiana); Anthony George Cofer (Lafayette, Indiana); Stephen Douglas Heister (West Lafayette, Indiana) |
| ABSTRACT | A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306811 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) B64G 1/50 (20130101) B64G 1/401 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0017 (20130101) Original (OR) Class F16K 99/0036 (20130101) F16K 2099/0092 (20130101) F16K 2099/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220054311 | Ohlinger |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terri Ohlinger (Fairfield, Ohio) |
| ABSTRACT | An apparatus for dispensing eye drops can comprise a housing that defines a receptacle. The receptacle can be configured to receive a cartridge having a solution therein. An actuator can be movable between a first position and a second position. The actuator can be positioned with respect to the receptacle so that, when the cartridge is received in the receptacle and the actuator is moved from the first position to the second position, the actuator deforms the cartridge by a select amount to dispense a predetermined quantity of solution from the cartridge. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399623 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0026 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220056075 | ZADINA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); DEPARTMENT OF VETERANS AFFAIRS (US) (Washington, District of Columbia) |
| ASSIGNEE(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); DEPARTMENT OF VETERANS AFFAIRS (US) (Washington, District of Columbia) |
| INVENTOR(S) | James E. ZADINA (Metaire, Louisiana) |
| ABSTRACT | A method for treating opioid use disorder comprises administering to a subject a pharmaceutical composition comprising a cyclic peptide of Formula I or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier; wherein the peptide of formula X1-c[X2-X3-Phe-X4]-X5 is administered in place of, and as a substitute for an opioid to which the subject is addicted. X1 is Tyr or 2,6-Dmt; X2 is an acidic or basic D-amino acid; X3 is Trp or Phe; there is an amide bond between the sidechains of X2 and X4; X5 is NHR (R=H or alkyl) or an amino acid amide. When X2 is an acidic D-amino acid, X4 is a basic amino acid, X3 is Phe, and X5 is NHR; and when X2 is a basic D-amino acid, X4 is an acidic amino acid, and X3 is Trp. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220060683 | Rzhanov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of New Hampshire (Durham, New Hampshire) |
| ASSIGNEE(S) | University of New Hampshire (Durham, New Hampshire) |
| INVENTOR(S) | Yuri Rzhanov (Durham, New Hampshire) |
| ABSTRACT | A system and method for colorimetric calibration is described herein. A system for performing color calibration is described, comprising at least one broad spectrum light emitting diode, at least one light diffuser plate, at least one interference filter, and a camera, the camera comprising at least one sensor for detection of colors, wherein a spectral response within 5% error of a ground truth method can be achieved. A method for performing color calibration is described, comprising transmitting light from at least one broad spectrum light emitting diode, scattering light with at least one light diffuser plate, filtering light with at least one interference filter, detecting light at a camera sensor, mapping an intensity value for each pixel of the camera sensor, and creating a quantum efficiency curve for each of red, green, and blue channels. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518105 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 9/0451 (20180801) H04N 17/002 (20130101) H04N 17/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220055478 | Hök et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Automotive Coalition for Traffic Safety, Inc. (Sterling, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertil Hök (Västerås, Sweden); Raimo Gester (Västerås, Sweden); Jonas Ljungblad (Stockholm, Sweden); Håkan Pettersson (Floda, Sweden) |
| ABSTRACT | Methods and apparatus allow for passive determination of a driver's Breath Alcohol Concentration (BrAC). Alcohol concentrations can be determined from exhaled breath, however inconvenience to a driver is often a barrier for incorporation of BrAC sensors into vehicles. The methods and apparatus allow for passive determination of a driver's BrAC, while detecting and accounting for a wide range of environmental conditions that may reduce the accuracy of a passive BrAC reading. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462318 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 28/06 (20130101) Original (OR) Class B60K 28/063 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0067 (20130101) G01N 33/4972 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220054708 | Murphy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Murphy (Waunakee, Wisconsin); Gianluca Fontana (Madison, Wisconsin); Joshua Gershlak (Worcester, Massachusetts); Glenn Gaudette (Worcester, Massachusetts); Pam Weathers (Worcester, Massachusetts); Tanja Dominko (Worcester, Massachusetts); Marsha Rolle (Worchester, Massachusetts); Sarah Hernandez (San Juan Capistrano, California); Carol Cramer (State University, Arkansas); Fabricio Medina-Bolivar (State University, Arkansas) |
| ABSTRACT | Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388652 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/54 (20130101) A61L 27/227 (20130101) A61L 27/3637 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 2300/25 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/04 (20130101) C12N 5/0068 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220054012 | Hillman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth Marjorie Clare Hillman (New York, New York); Sean A. BURGESS (New York, New York) |
| ABSTRACT | Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM). |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462824 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0064 (20130101) Original (OR) Class A61B 5/0066 (20130101) A61B 5/0071 (20130101) A61B 5/0073 (20130101) A61B 5/0075 (20130101) A61B 5/0088 (20130101) A61B 5/444 (20130101) A61B 5/445 (20130101) A61B 2562/0238 (20130101) A61B 2562/0242 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) G01J 3/457 (20130101) G01J 3/2889 (20130101) Optical Elements, Systems, or Apparatus G02B 23/2476 (20130101) G02B 26/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220055427 | Shiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leung Man Shiu (Gaithersburg, Maryland); Edward F. Houston (Bristow, Virginia); Anthony B. Taylor (Stafford, Virginia); Scott R. Bombaugh (Burke, Virginia) |
| ABSTRACT | This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519005 |
| CURRENT CPC | Vehicle Connections B60D 1/54 (20130101) B60D 1/141 (20130101) Original (OR) Class B60D 1/1675 (20130101) B60D 2001/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220054624 | Marasco |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts) |
| ABSTRACT | The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405748 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 24, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/details-applications-20220224.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page