FedInvent™ Patent Applications

Application Details for Thursday, March 31, 2022 

This page was updated on Tuesday, April 05, 2022 at 05:15 AM GMT

Department of Health and Human Services (HHS) 

US 20220095597 Piedrahita
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S) North Carolina State University (Raleigh, North Carolina)
INVENTOR(S) Jorge A. Piedrahita (Raleigh, North Carolina)
ABSTRACT The present disclosure provides compositions and methods related to the generation and use of transgenic animal models having stem cell reporter systems. In particular, the present disclosure provides a novel transgenic animal model that expresses a nuclear-localized fluorescent reporter in cells endogenously expressing a leucine-rich repeat-containing G-protein coupled receptor (LGR) gene (e.g., LGR5gene). Given the role of LGR genes in stem cell and cancer biology, the transgenic animal models provided herein are useful for a wide range of therapeutic and diagnostic purposes.
FILED Friday, January 24, 2020
APPL NO 17/425626
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0278 (20130101) Original (OR) Class
A01K 2227/105 (20130101)
A01K 2227/108 (20130101)
A01K 2267/01 (20130101)
A01K 2267/0331 (20130101)
A01K 2267/0393 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0628 (20130101)
C12N 5/0678 (20130101)
C12N 15/8509 (20130101)
C12N 2015/8572 (20130101)
C12N 2510/04 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5073 (20130101)
G01N 2800/20 (20130101)
G01N 2800/7028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220095607 Uygun et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mustafa Korkut Uygun (Newton, Massachusetts);  Laura Burlage (Amsterdam, Netherlands);  Shannon N. Tessier (Framingham, Massachusetts);  Curtis L. Cetrulo (Cohasset, Massachusetts);  Alexandre G. Lellouch (Harrison, New York);  Reinier Johan De Vries (Boston, Massachusetts);  Mehmet Toner (Charlestown, Massachusetts)
ABSTRACT This disclosure relates to subnormothermic machine perfusion formulations for ex vivo preservation of allografts, and methods of use thereof.
FILED Wednesday, February 05, 2020
APPL NO 17/428593
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
A01N 1/0226 (20130101)
A01N 1/0247 (20130101)
A01N 1/0284 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220095614 Ausubel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts);  Temple University-of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania);  Rhode Island Hospital, A Lifespan-Partner (Providence, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Frederick M. Ausubel (Newton, Massachusetts);  Wooseong Kim (Providence, Rhode Island);  Eleftherios Mylonakis (Providence, Rhode Island);  William M. Wuest (Atlanta, Georgia)
ABSTRACT The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
FILED Tuesday, November 23, 2021
APPL NO 17/456244
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 31/08 (20130101) Original (OR) Class

Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Acyclic or Carbocyclic Compounds
C07C 39/17 (20130101)
C07C 65/11 (20130101)
C07C 65/17 (20130101)
C07C 235/66 (20130101)
C07C 2603/74 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220095615 Chalasani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California);  CORNELL UNIVERSITY (Ithaca, New York);  BOYCE THOMPSON INSTITUTE (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Sreekanth H. Chalasani (San Diego, California);  Zheng Liu (San Diego, California);  Frank Schroeder (Ithaca, New York);  Maro Kariya (Brooklyn, New York)
ABSTRACT The present disclosure provides compositions comprising a nematode deterrent comprising a compound of Formula I. Also provided are related articles of manufacture, uses and methods.
FILED Tuesday, October 12, 2021
APPL NO 17/499691
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/04 (20130101)
A01N 31/02 (20130101)
A01N 37/02 (20130101) Original (OR) Class
A01N 37/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220095944 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Xin Zhang (Medford, Massachusetts);  Stephan Anderson (Cambridge, Massachusetts);  Xiaoguang Zhao (Charlestown, Massachusetts);  Guangwu Duan (Cupertino, California)
ABSTRACT A passive MRI enhancing embodiment includes a plurality of resonators and increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the magnetic field component of radiofrequency energy during signal transmission from the MRI machine to the specimen, and/or reception of signals from the specimen to the MRI machine. Use of the apparatus improves the images generated by the MRI machine, and/or reduces the time necessary for the MRI machine to capture the image. An isolator embodiment has a nonlinear resonator controllably configurable alternately into an isolation configuration and a transmission configuration, and a second resonator. The nonlinear resonator is coupled to a communications port and is substantially communicatively isolated from the second resonator when the nonlinear resonator is in the isolation configuration, and is communicatively coupled to the second resonator when the nonlinear resonator is in the transmission configuration.
FILED Wednesday, December 08, 2021
APPL NO 17/545538
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/055 (20130101) Original (OR) Class

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/12 (20130101)
G01R 33/3415 (20130101)
G01R 33/34038 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220095961 White et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S) University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S) Ryan J. White (Cincinnati, Ohio);  Sierra Mize (Hamilton, Ohio);  Robert Lazenby (Cincinnati, Ohio);  Tatiana Ilina (Cincinnati, Ohio)
ABSTRACT Methods and system of using a target-binding aptasensor to determine a concentration of a target in a media may include dispensing target in the media, applying an intermittent pulse amperometry (“IPA”) waveform to the target-binding aptasensor in the media to sense the target, determining a reference point of the target-binding aptasensor to set a baseline level corresponding to the reference point, and determining the concentration of the target in the media based on the baseline level of the reference point.
FILED Tuesday, February 04, 2020
APPL NO 17/426365
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/1468 (20130101) Original (OR) Class
A61B 5/1486 (20130101)
A61B 5/14546 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096030 Yeh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Benjamin M. Yeh (Hillsborough, California);  Yanjun Fu (San Francisc, California)
ABSTRACT The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation. The invention also provides methods for imaging of the abdomen by dual energy CT or spectral CT contemporaneously with the delivery of the encapsulated gas or partial vacuum particle contrast material into the bowel lumen with or without the deliver of a second complementary contrast material into the blood vessels or other body compartments. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues to generate multiple resultant CT images with the contrast medium of the invention subtracted or highlighted.
FILED Monday, September 13, 2021
APPL NO 17/473590
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/03 (20130101)
A61B 6/032 (20130101)
A61B 6/481 (20130101) Original (OR) Class
A61B 6/482 (20130101)
A61B 6/484 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/10 (20130101)
A61K 9/50 (20130101)
A61K 49/0419 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096056 Alizad et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Azra Alizad (Rochester, Minnesota);  Mahdi Bayat (Cleveland, Ohio);  Mostafa Fatemi (Rochester, Minnesota)
ABSTRACT Methods and systems for producing a visually-perceived representation of a sub-millimeter-sized blood vessel located at a depth of many centimeters in the biological tissue, in which the background clutter is suppressed (by at least 30 dB using SVT and additional 23 dB using a combination of morphology filtering and vessel enhancement filtering) as compared to an image obtained with the use of a B-mode ultrasound imaging, while at the same time maintaining the morphology of the blood vessel.
FILED Monday, November 29, 2021
APPL NO 17/536625
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 8/06 (20130101)
A61B 8/14 (20130101)
A61B 8/463 (20130101)
A61B 8/488 (20130101)
A61B 8/0891 (20130101)
A61B 8/4444 (20130101)
A61B 8/5223 (20130101) Original (OR) Class
A61B 8/5246 (20130101)
A61B 8/5276 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096060 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Cleveland, Ohio);  Amitabh Chak (Cleveland, Ohio);  Joseph Willis (Cleveland, Ohio);  Jeffrey Silver Taggart (Cleveland, Ohio);  Rebecca Blice (Cleveland, Ohio);  Dean Secrest (Cleveland, Ohio);  Dennis Siedlak (Cleveland, Ohio)
ABSTRACT A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
FILED Wednesday, December 08, 2021
APPL NO 17/643299
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101) Original (OR) Class
A61B 2010/0216 (20130101)
A61B 2010/0225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096061 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Cleveland, Ohio);  Amitabh Chak (Cleveland, Ohio);  Joseph Willis (Cleveland, Ohio);  Jeffrey Silver Taggart (Cleveland, Ohio);  Rebecca Blice (Cleveland, Ohio);  Dean Secrest (Cleveland, Ohio);  Dennis Siedlak (Cleveland, Ohio)
ABSTRACT A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
FILED Wednesday, December 08, 2021
APPL NO 17/643320
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101) Original (OR) Class
A61B 2010/0216 (20130101)
A61B 2010/0225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096062 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Cleveland, Ohio);  Amitabh Chak (Cleveland, Ohio);  Joseph Willis (Cleveland, Ohio);  Jeffrey Silver Taggart (Cleveland, Ohio);  Rebecca Blice (Cleveland, Ohio);  Dean Secrest (Cleveland, Ohio);  Dennis Siedlak (Cleveland, Ohio)
ABSTRACT A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
FILED Wednesday, December 08, 2021
APPL NO 17/643329
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101) Original (OR) Class
A61B 2010/0216 (20130101)
A61B 2010/0225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096063 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Cleveland, Ohio);  Amitabh Chak (Cleveland, Ohio);  Joseph Willis (Cleveland, Ohio);  Jeffrey Silver Taggart (Cleveland, Ohio);  Rebecca Blice (Cleveland, Ohio);  Dean Secrest (Cleveland, Ohio);  Dennis Siedlak (Cleveland, Ohio)
ABSTRACT A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
FILED Wednesday, December 08, 2021
APPL NO 17/643335
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101) Original (OR) Class
A61B 2010/0216 (20130101)
A61B 2010/0225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096064 Markowitz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sanford Markowitz (Cleveland, Ohio);  Amitabh Chak (Cleveland, Ohio);  Joseph Willis (Cleveland, Ohio);  Jeffrey Silver Taggart (Cleveland, Ohio);  Rebecca Blice (Cleveland, Ohio);  Dean Secrest (Cleveland, Ohio);  Dennis Siedlak (Cleveland, Ohio)
ABSTRACT A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
FILED Wednesday, December 08, 2021
APPL NO 17/643341
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101) Original (OR) Class
A61B 2010/0216 (20130101)
A61B 2010/0225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096368 CROYLE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S) Maria A. CROYLE (Austin, Texas);  Jin Huk CHOI (Austin, Texas);  Stephen Clay Schafer (Austin, Texas)
ABSTRACT Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.
FILED Friday, October 15, 2021
APPL NO 17/502785
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/006 (20130101) Original (OR) Class
A61K 39/12 (20130101)
A61K 47/26 (20130101)
A61K 2039/5256 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/04 (20130101)
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096391 CHOU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) James CHOU (Cambridge, Massachusetts);  Wen CHEN (Cambridge, Massachusetts)
ABSTRACT Presentation of membrane proteins to host immune systems has been a challenging problem due to complexity arising from the poor in vivo stability of the membrane-mimetic media often used for solubilizing the membrane proteins. The Inventors report the use of functionalized, biocompatible nanoparticles as substrates to guide the formation of proteoliposomes that can present many copies of membrane proteins in a unidirectional manner. The approach was demonstrated to present the membrane-proximal region of the HIV-1 envelope glycoprotein. These nanoparticle-supported liposomes are broadly applicable as membrane antigen vehicles for inducing host immune responses. In some instances, the technology supports generation of antibodies that do not generate an immunogenic response in comparison to conventional protein presentation (i.e., liposome).
FILED Thursday, December 26, 2019
APPL NO 17/419160
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/1271 (20130101)
A61K 9/5115 (20130101) Original (OR) Class
A61K 39/21 (20130101)
A61K 2039/55555 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2740/16234 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/54346 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096401 Montemurro et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Luigi Taranto Montemurro (Brookline, Massachusetts);  D. Andrew Wellman (Wayland, Massachusetts)
ABSTRACT Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of (i) a norepinephrine reuptake inhibitor (NRI) and (ii) a non myorelaxing hypnotic and/or 5-HT2A inverse agonist or antagonist.
FILED Friday, February 07, 2020
APPL NO 17/428596
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/138 (20130101) Original (OR) Class
A61K 31/437 (20130101)
A61K 31/497 (20130101)
A61K 31/4468 (20130101)
A61K 31/5375 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096441 Boykin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia);  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia);  UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
ASSIGNEE(S) GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia);  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia);  UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
INVENTOR(S) David W. Boykin (Atlanta, Georgia);  Dennis E. Kyle (Athens, Georgia);  Christopher A. Rice (Athens, Georgia);  Abdelbasset A. Farahat (Atlanta, Georgia)
ABSTRACT Compounds, compositions, and methods for the treatment of infections caused by Acanthamoeba or Balamuthia mandrillaris trophozoites and/or cysts and for the disinfection of solids and/or liquids, such as medical and personal care items, for example contact lenses, that may harbor Acanthamoeba trophozoites and/or cysts are provided.
FILED Thursday, October 17, 2019
APPL NO 17/286058
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/52 (20130101)
A01N 43/54 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/155 (20130101)
A61K 31/496 (20130101)
A61K 31/506 (20130101)
A61K 31/661 (20130101)
A61K 31/785 (20130101)
A61K 31/4174 (20130101)
A61K 31/4184 (20130101) Original (OR) Class
A61K 31/4196 (20130101)
A61K 31/7036 (20130101)
A61K 38/12 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/04 (20180101)

Heterocyclic Compounds
C07D 235/18 (20130101)
C07D 235/20 (20130101)
C07D 403/04 (20130101)
C07D 403/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096446 SHARP et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Zelton Dave SHARP (San Antonio, Texas);  Randy STRONG (San Antonio, Texas);  Paul HASTY (San Antonio, Texas);  Carolina LIVI (San Antonio, Texas);  Arlan RICHARDSON (San Antonio, Texas)
ABSTRACT Disclosed are methods and compositions for the treatment or prevention of intestinal polyps or prevention of cancer in a patient who has been identified as being at risk for developing intestinal polyps or intestinal cancer. The disclosed methods and compositions include rapamycin, a rapamycin analog, or another such inhibitor of the target of rapamycin (TOR).
FILED Thursday, December 02, 2021
APPL NO 17/540827
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5138 (20130101)
A61K 31/192 (20130101)
A61K 31/415 (20130101)
A61K 31/436 (20130101) Original (OR) Class
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096450 JORNS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) DREXEL UNIVERSITY (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Marilyn S. JORNS (Philadelphia, Pennsylvania);  Michael R. JACKSON (Crossville, Tennessee);  Kristie D. COX (Charleston, South Carolina);  Patrick Y. S. LAM (Philadelphia, Pennsylvania);  Simon D. P. BAUGH (Ringoes, New Jersey)
ABSTRACT The present invention relates to the discovery of compounds that can be used to treat and/or prevent heart failure in a subject. In certain embodiments, the compounds of the invention are sulfide:quinone oxidoreductase (SQOR) inhibitors. In other embodiments, the compounds of the invention increase physiological levels of H2S in the subject. In yet other embodiments, administration of the compounds of the invention treats, ameliorates, and/or prevents hypertension, and/or atherosclerosis, and/or pathological cardiac remodeling that leads to heart failure in the subject.
FILED Thursday, January 09, 2020
APPL NO 17/421821
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/444 (20130101) Original (OR) Class
A61K 31/496 (20130101)
A61K 31/505 (20130101)
A61K 31/4418 (20130101)
A61K 31/5377 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/04 (20180101)

Heterocyclic Compounds
C07D 213/64 (20130101)
C07D 239/34 (20130101)
C07D 401/04 (20130101)
C07D 401/14 (20130101)
C07D 405/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096459 Xu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S) Xiaowei Xu (Monmouth Drive, New Jersey);  Shujing Liu (Philadelphia, Pennsylvania);  Alain Rook (Wynnewood, Pennsylvania);  Pankaj Karande (Troy, New York)
ABSTRACT Compositions and methods for treatment of viral skin disease, precancerous and cancerous skin disease, and other neoplasms are disclosed.
FILED Tuesday, October 12, 2021
APPL NO 17/499248
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 9/0019 (20130101)
A61K 31/444 (20130101)
A61K 31/4745 (20130101) Original (OR) Class
A61K 38/217 (20130101)
A61K 39/00 (20130101)
A61K 39/39558 (20130101)
A61K 41/0057 (20130101)
A61K 45/06 (20130101)
A61K 47/12 (20130101)
A61K 47/14 (20130101)
A61K 47/20 (20130101)
A61K 2300/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/12 (20180101)
A61P 35/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096466 Chinta et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Buck Institute for Research and Aging (Novato, California);  Unity Biotechnology, Inc. (South San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Shankar J. Chinta (Novato, California);  Judith Campisi (Berkeley, California);  Julie K. Andersen (Novato, California);  Remi-Martin Laberge (San Francisco, California);  Nathaniel David (San Francisco, California)
ABSTRACT This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.
FILED Friday, December 10, 2021
APPL NO 17/548004
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 9/0073 (20130101)
A61K 31/404 (20130101)
A61K 31/428 (20130101)
A61K 31/495 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 31/728 (20130101)
A61K 31/4178 (20130101)
A61K 31/4375 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
A61K 47/36 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
A61P 11/00 (20180101)
A61P 25/16 (20180101)
A61P 27/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0081 (20130101)
C12N 2503/02 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/485 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096480 Eoff et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Aging (NIA)
APPLICANT(S) BioVentures, LLC (Little Rock, Arkansas)
ASSIGNEE(S)
INVENTOR(S) Robert Eoff (Little Rock, Arkansas);  Narsimha Penthala (Little Rock, Arkansas);  Peter Crooks (Little Rock, Arkansas)
ABSTRACT The present disclosure provides compositions and methods for the inhibition of DNA polymerases. The methods and compositions as described herein are useful in the treatment of cancer. In particular, the present disclosure provides compositions comprising one or more of indole-derived compounds useful in treatment of cancers including those which are resistant to genotoxic therapies.
FILED Tuesday, January 14, 2020
APPL NO 17/423060
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/513 (20130101)
A61K 31/515 (20130101) Original (OR) Class
A61K 31/565 (20130101)
A61K 31/4045 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 209/14 (20130101)
C07D 403/06 (20130101)
C07D 471/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096484 Gabrilovich et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Wistar Institute of Anatomy and Biology (Phitadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Dmitry I. Gabrilovich (Villanova, Pennsylvania);  Filippo Veglia (Philadelphia, Pennsylvania)
ABSTRACT A method of treating cancer in a subject in need thereof is provided. The method includes administering an agent that inhibits, decreases, deletes or downregulates FATP2. In one embodiment, the method includes administering a checkpoint inhibitor. Also provided are methods of decreasing MDSCs and MDSC immune-suppressive activity in a subject in need thereof.
FILED Friday, February 21, 2020
APPL NO 17/429718
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/433 (20130101)
A61K 31/519 (20130101) Original (OR) Class
A61K 39/3955 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/2818 (20130101)
C07K 16/2866 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096492 KIMBALL et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey)
ASSIGNEE(S) RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey)
INVENTOR(S) Spencer David KIMBALL (New Brunswick, New Jersey);  Darren R. CARPIZO (New Brunswick, New Jersey);  John A. GILLERAN (New Brunswick, New Jersey)
ABSTRACT The invention provides a complex comprising Zn2+ and a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.
FILED Wednesday, April 22, 2020
APPL NO 17/605750
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/282 (20130101)
A61K 31/337 (20130101)
A61K 31/437 (20130101)
A61K 31/475 (20130101)
A61K 31/506 (20130101)
A61K 31/555 (20130101) Original (OR) Class
A61K 31/704 (20130101)
A61K 31/4745 (20130101)
A61K 31/5545 (20170801)
A61K 31/7068 (20130101)
A61K 38/14 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 3/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096503 Ho et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Rodney J.Y. Ho (Seattle, Washington);  Jesse Yu (Seattle, Washington);  Lisa McConnachie (Seattle, Washington)
ABSTRACT Described herein are combination pharmaceutical compositions including a combination of hydrophilic and hydrophobic therapeutic agents (i.e., drugs) that are assembled together with excipients under specific conditions, forming a homogeneous pharmaceutical powder with unified repetitive multi-drug motif (MDM) structure. Unlike currently available drug combination powders, which are amorphous, the combination pharmaceutical compositions (e.g., combination therapeutic agent powders) of the present disclosure have long range order, in the form of repetitive multi-drug and unified motifs
FILED Friday, January 10, 2020
APPL NO 17/422074
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/1694 (20130101)
A61K 31/427 (20130101)
A61K 31/505 (20130101)
A61K 31/506 (20130101)
A61K 31/513 (20130101)
A61K 31/675 (20130101) Original (OR) Class
A61K 31/5365 (20130101)
A61K 47/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096513 CORSELLO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts)
INVENTOR(S) STEVEN M. CORSELLO (BOSTON, Massachusetts);  TODD R. GOLUB (CAMBRIDGE, Massachusetts);  ERIC STEFAN (CAMBRIDGE, Massachusetts);  ROBERT HILGRAF (CAMBRIDGE, Massachusetts)
ABSTRACT The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.
FILED Friday, March 30, 2018
APPL NO 16/498897
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/498 (20130101)
A61K 31/4439 (20130101)
A61K 31/7064 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096515 Vasudevan
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Huntington Medical Research Institutes (Pasadena, California)
ASSIGNEE(S) Huntington Medical Research Institutes (Pasadena, California)
INVENTOR(S) Anju Vasudevan (Pasadena, California)
ABSTRACT Methods of treatment and pharmaceutical formulations configured to prevent psychiatric diseases and/or disorders in offspring are provided. The methods and treatments use a regulator of angiogenesis pathways. The regulator can restore GABA secretion and neuronal migration. The regulator may be administered during pregnancy of an individual, thus allowing proper development of a fetal brain.
FILED Tuesday, September 28, 2021
APPL NO 17/488061
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 31/7084 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096526 HAMRAH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Tufts Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Pedram HAMRAH (Wellesley, Massachusetts);  Arsia JAMALI (Boston, Massachusetts)
ABSTRACT The invention relates to methods and compositions for use in the treatment and prevention of ocular diseases and conditions.
FILED Wednesday, January 22, 2020
APPL NO 17/425058
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 31/7125 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096539 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia);  The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Jin Xie (Athens, Georgia);  Wen Jiang (Athens, Georgia);  Trever Todd (Fountain Valley, California);  Zibo Li (Chapel Hill, North Carolina)
ABSTRACT Particles formed from an alkai metal or alkaline earth metal and halide, for example, sodium and chloride, are provided. The particles can have a hydrophilic coating or external layer, formed of, for example, a polyether-lipid conjugate. In preferred embodiments, the lipid is a phospholipid such as a phosphoethanolamine, and the polyether is a polyethylene glycol such as a PEG amine. Methods making the particles by, for example, a microemulsion reaction, are also provided. Pharmaceutical compositions including a plurality of particles and a pharmaceutically acceptable carrier are also disclosed. Typically the compositions include an effective amount of particles to treat a disease or condition, particularly cancer, in a subject in need thereof. The particles are typically nanoparticles, for example, between about 10 nm and 250 nm and can be monodisperse.
FILED Friday, January 17, 2020
APPL NO 17/424109
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5015 (20130101)
A61K 33/14 (20130101) Original (OR) Class
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)
A61K 2039/5152 (20130101)
A61K 2039/55505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096543 LI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) VIRGINA TECH INTELLECTUAL PROPERTIES, INC. (BLACKSBURG, Virginia)
ASSIGNEE(S)
INVENTOR(S) Liwu LI (Blacksburg, Virginia);  Yao ZHANG (Blacksburg, Virginia);  Christina LEE (Blacksburg, Virginia)
ABSTRACT Described herein are modified cells and compositions thereof, wherein the cells can have reduced or eliminated Tollip gene and/or protein expression. In some embodiments, the modified cells can be neutrophils. Also described herein are methods of making and using the modified cells and compositions thereof. In some embodiments, the modified cells having reduced or eliminated Tollip gene and/or protein expression can be administered to a subject in need thereof.
FILED Monday, December 23, 2019
APPL NO 17/418037
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)
A61K 35/15 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/907 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096553 CROOKS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Gay M. CROOKS (Sherman Oaks, California);  Amélie MONTEL-HAGEN (Los Angeles, California);  Christopher SEET (Santa Monica, California)
ABSTRACT Methods and composition for production of T cells are provided. Also provided are therapeutic methods using engineered T cells. For example, in certain aspects methods include preparing three dimensional cell culture compositions comprising stroma cells and hematopoietic stem or progenitor cells in a serum-free medium for producing T cells.
FILED Friday, September 17, 2021
APPL NO 17/478875
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/705 (20130101)
C07K 2317/622 (20130101)
C07K 2319/03 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/00 (20130101)
C12N 5/0037 (20130101)
C12N 5/0062 (20130101)
C12N 5/0606 (20130101)
C12N 5/0636 (20130101)
C12N 5/0663 (20130101)
C12N 5/0669 (20130101)
C12N 5/0696 (20130101)
C12N 2500/22 (20130101)
C12N 2500/24 (20130101)
C12N 2500/32 (20130101)
C12N 2500/38 (20130101)
C12N 2500/90 (20130101)
C12N 2501/15 (20130101)
C12N 2501/25 (20130101)
C12N 2501/125 (20130101)
C12N 2501/145 (20130101)
C12N 2501/2302 (20130101)
C12N 2501/2304 (20130101)
C12N 2501/2306 (20130101)
C12N 2501/2307 (20130101)
C12N 2501/2315 (20130101)
C12N 2501/2321 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096560 Mitsialis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S) Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S) S. Alexander Mitsialis (Newton, Massachusetts);  Changjin Lee (Boston, Massachusetts);  Stella Kourembanas (Newton, Massachusetts)
ABSTRACT The invention provides compositions comprising mesenchymal stem cell (MSC) derived exosomes, and methods of their use in subjects having certain lung diseases including inflammatory lung disease.
FILED Friday, October 01, 2021
APPL NO 17/492276
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0078 (20130101)
A61K 35/28 (20130101) Original (OR) Class
A61K 35/42 (20130101)
A61K 38/1709 (20130101)
A61K 45/06 (20130101)
A61K 47/10 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0663 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096566 BRY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts);  THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S) THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S) Lynn BRY (Jamaica Plain, Massachusetts);  Talal A. CHATILA (Belmont, Massachusetts);  Georg GERBER (Newton, Massachusetts);  Azza ABDEL-GADIR (Cambridge, Massachusetts);  Rima RACHID (Belmont, Massachusetts)
ABSTRACT Disclosed are methods and compositions for the prevention and treatment of dysbiosis and associated conditions. In particular, described herein are compositions of microbial consortia, including minimal microbial consortia, that can prevent and/or cure dysbiosis and associated conditions. In certain embodiments, the microbial consortia comprise certain members of the taxa Clostridiales, Bacteroidetes, Prevotella, and/or Parabacteroides.
FILED Friday, November 08, 2019
APPL NO 17/292482
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/741 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/14 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096567 Pamer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Memorial Sloan Kettering Cancer Center (New York, New York)
ASSIGNEE(S) Memorial Sloan Kettering Cancer Center (New York, New York)
INVENTOR(S) Eric Pamer (Montclair, New Jersey);  Peter McKenney (New York, New York);  Silvia Caballero (Cambridge, Massachusetts)
ABSTRACT The present invention relates to methods and compositions for reducing the risk and severity of vancomycin-resistant Enterococci infection or colonization. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacteria Clostridium scindens and/or the bacteria Blautia producta contribute substantially to resistance against vancomycin-resistant Enterococci infection or colonization. Without being bound by any particular theory, it is believed that this is achieved through the biosynthesis of secondary bile acids in the case of Clostridium scindens.
FILED Monday, December 13, 2021
APPL NO 17/549811
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0031 (20130101)
A61K 9/0043 (20130101)
A61K 9/0053 (20130101)
A61K 35/74 (20130101)
A61K 35/741 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)

Enzymes
C12Y 101/00 (20130101)
C12Y 101/01201 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096575 Needham et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
APPLICANT(S) California Institute of Technology (Pasadena, California);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Brittany D. Needham (Pasadena, California);  Sarkis K. Mazmanian (Pasadena, California);  Gil Sharon (Pasadena, California);  Masanori Funabashi (San Francisco, California);  Michael A. Fischbach (San Francisco, California);  Elaine Y. Hsiao (Pasadena, California);  Paul H. Patterson (Pasadena, California)
ABSTRACT Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
FILED Friday, July 23, 2021
APPL NO 17/443273
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 33/135 (20160801)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0031 (20130101)
A61K 9/0053 (20130101)
A61K 35/747 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096577 O'Shea et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Salk Institute for Biological Studies (La Jolla, California)
ASSIGNEE(S) Salk Institute for Biological Studies (La Jolla, California)
INVENTOR(S) Clodagh O'Shea (San Diego, California);  Shigeki Miyake-Stoner (La Jolla, California)
ABSTRACT An adenovirus comprising an E1A polypeptide comprising one or more modifications and comprising an E4orf6/7 polypeptide comprising one or more modifications is described. Compositions and kits comprising the modified adenoviruses are also described. Further described is a method of treating a proliferative disorder in a subject comprising administering to the subject an adenovirus comprising the E1A polypeptide comprising one or more modifications and comprising the E4orf6/7 polypeptide comprising one or more modifications.
FILED Friday, July 09, 2021
APPL NO 17/371546
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/761 (20130101) Original (OR) Class
A61K 35/768 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101)
C12N 2710/10021 (20130101)
C12N 2710/10032 (20130101)
C12N 2710/10043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096594 MILLWARD et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Steven MILLWARD (Houston, Texas);  Joshua GRAY (Houston, Texas)
ABSTRACT Provided herein are cyclic peptide inhibitors of autophagy that bind to LC3. These cyclic peptides may be used to treat diseases or disorders associated with autophagy, such as, for example, cancer, diabetes, cardiovascular disease, and neurological disorders. These cyclic peptides may also be used to sensitize cancers to front-line chemotherapy, immunotherapy, and/or radiation therapy.
FILED Thursday, January 30, 2020
APPL NO 17/425546
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/282 (20130101)
A61K 33/243 (20190101)
A61K 38/12 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 49/0056 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096600 Park et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)
INVENTOR(S) Dongsu Park (Houston, Texas);  Laura Ortinau (Manvel, Texas)
ABSTRACT Embodiments of the disclosure encompass methods and compositions for bone repair and bone injury healing. In some embodiments, the bone repair and bone injury healing utilizes the enhancement of migration of certain types of bone cells upon stimulation by a particular cytokine. In specific embodiments, migration of periosteal skeletal stem cells upon delivery of CCL5 and/or TNFα is enhanced and fosters bone repair and healing.
FILED Friday, February 07, 2020
APPL NO 17/310119
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/18 (20130101)
A61K 38/19 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/36 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 19/08 (20180101)

Peptides
C07K 14/51 (20130101)
C07K 14/52 (20130101)
C07K 16/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096601 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Chensu Wang (Allston, Massachusetts);  Karl Dane Wittrup (Boston, Massachusetts);  Darrell J. Irvine (Arlington, Massachusetts)
ABSTRACT The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.
FILED Thursday, December 02, 2021
APPL NO 17/540477
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/2013 (20130101) Original (OR) Class
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/3955 (20130101)
A61K 39/39558 (20130101)
A61K 2039/507 (20130101)
A61K 2039/545 (20130101)
A61K 2039/55561 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096602 HU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Rutgers, the State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Wenwei HU (Belle Mead, New Jersey);  Zhaohui FENG (Belle Mead, New Jersey);  Huaying WANG (Ningbo, Zhejiang, China PRC);  Jianming WANG (Edison, New Jersey)
ABSTRACT Disclosed herein are new therapeutic methods and compositions for maintaining and regenerating intestinal epithelial cells in a mammal. In a specific embodiment, the methods involve administering an amount LIF that induces intestinal epithelial cell regeneration. The methods and compositions are useful for preventing or treating gastrointestinal radiation injury or GVHD.
FILED Thursday, February 27, 2020
APPL NO 17/432177
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 38/2093 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/00 (20180101)
A61P 37/06 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0679 (20130101)
C12N 2501/235 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096618 Hazlett et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) ALBANY MEDICAL COLLEGE (Albany, New York)
ASSIGNEE(S) ALBANY MEDICAL COLLEGE (Albany, New York)
INVENTOR(S) Karsten Hazlett (East Berne, New York);  Kristen M. Tummillo (Union, New Jersey);  Edmund J. Gosselin (Glenmont, New York)
ABSTRACT An approach for modifying multiple types of bacteria to produce surface modifications that enhance the immunologic response when used as a vaccine. A series of plasmids (pYF, pYFC, pYFP, pSF, pSPF, and pSCF) may be used to transform bacteria which then produce surface-exposed ligands that bind to complement receptors on antigen presenting cells. When modified bacteria are used as a vaccine, the vaccine recipients produce significantly higher titers of specific antibodies and are better protected against challenges from the disease-causing bacteria.
FILED Tuesday, September 29, 2020
APPL NO 17/036526
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/164 (20130101)
A61K 38/1725 (20130101)
A61K 39/02 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/87 (20130101)
C12N 2310/3517 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096622 BAROUCH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Janssen Vaccines and Prevention B.V. (Leiden, Netherlands);  Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Dan BAROUCH (Newton, Massachusetts);  Johanna SCHUITEMAKER (Amstelveen, Netherlands);  Maria Grazia PAU (Leiden, Netherlands);  Danielle VAN MANEN (Leiden, Netherlands);  Frank TOMAKA (Titusville, New Jersey);  Jennifer Anne HENDRIKS (Poeldijk, Netherlands)
ABSTRACT Compositions, vaccines and methods for inducing an immunity, including a protective immunity, against Human Immunodeficiency Virus (HIV) infection are described. Heterologous vaccine combinations of one or more adenovirus 26 vectors using for priming immunization and an isolated HIV antigenic polypeptide in combination with one or more MVA vectors for boosting immunization induced strong protective immunity against infections by one or multiple clades of HIV.
FILED Monday, December 06, 2021
APPL NO 17/457705
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/21 (20130101) Original (OR) Class
A61K 2039/55505 (20130101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101)
C12N 2710/10043 (20130101)
C12N 2710/24143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096627 DICKEY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) PULMOTECT, INC. (Houston, Texas);  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas);  BAYLOR COLLEGE OF MEDICINE (Houston, Texas)
ASSIGNEE(S)
INVENTOR(S) BURTON DICKEY (HOUSTON, Texas);  SCOTT EVANS (BELLAIRE, Texas);  BRIAN GILBERT (HOUSTON, Texas);  DIANE MARKESICH (HOUSTON, Texas);  MICHAEL TUVIM (HOUSTON, Texas)
ABSTRACT Embodiments are directed to compositions and methods for treating viral infections.
FILED Wednesday, August 11, 2021
APPL NO 17/399821
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0078 (20130101)
A61K 31/24 (20130101)
A61K 31/215 (20130101)
A61K 31/7056 (20130101)
A61K 38/05 (20130101)
A61K 38/06 (20130101)
A61K 38/07 (20130101)
A61K 38/08 (20130101)
A61K 39/39 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 2039/55561 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096628 Yantasee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
APPLICANT(S) Oregon Health and Science University (Portland, Oregon);  PDX Pharmaceuticals, Inc. (Portland, Oregon)
ASSIGNEE(S) Oregon Health and Science University (Portland, Oregon);  PDX Pharmaceuticals, Inc. (Portland, Oregon)
INVENTOR(S) Wassana Yantasee (Lake Oswego, Oregon);  Amanda Lund (Portland, Oregon);  Worapol Ngamcherdtrakul (Portland, Oregon);  Moataz Reda (Portland, Oregon)
ABSTRACT Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals.
FILED Monday, December 13, 2021
APPL NO 17/549817
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 9/0021 (20130101)
A61K 9/1676 (20130101)
A61K 31/519 (20130101)
A61K 31/7105 (20130101)
A61K 39/39 (20130101) Original (OR) Class
A61K 2039/55561 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 15/1135 (20130101)
C12N 2310/141 (20130101)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096632 HAYNES et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Duke University (Durham, North Carolina);  University of Maryland (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Barton F. HAYNES (Durham, North Carolina);  Hua-Xin LIAO (Durham, North Carolina);  M. Anthony MOODY (Durham, North Carolina);  LaTonya WILLIAMS (Durham, North Carolina);  Kevin J. WIEHE (Durham, North Carolina);  Gilad Adi OFEK (College Park, Maryland)
ABSTRACT The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
FILED Thursday, June 24, 2021
APPL NO 17/357725
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/42 (20130101) Original (OR) Class
A61K 39/44 (20130101)
A61K 2039/507 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Peptides
C07K 16/1045 (20130101)
C07K 2299/00 (20130101)
C07K 2317/24 (20130101)
C07K 2317/54 (20130101)
C07K 2317/55 (20130101)
C07K 2317/56 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096636 Khan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Atif J. Khan (Monroe, New Jersey);  Suzie Chen (Highland Park, New Jersey);  James S. Goydos (East Brunswick, New Jersey);  Bruce G. Haffty (Somerset, New Jersey)
ABSTRACT Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.
FILED Wednesday, December 08, 2021
APPL NO 17/545559
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 41/0038 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096642 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Creighton University (Omaha, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Santanu Hati (Omaha, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska);  Robert Hazlitt (Boulder, Colorado);  Jaeki Min (Memphis, Tennessee)
ABSTRACT Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.
FILED Tuesday, September 28, 2021
APPL NO 17/488080
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/55 (20170801) Original (OR) Class
A61K 47/545 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096645 CAMACHO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Kathryn M. CAMACHO (Los Angeles, California);  Stefano MENEGATTI (Raleigh, North Carolina);  Sunny KUMAR (Aliso Viejo, California);  Douglas VOGUS (Goleta, California);  Samir MITRAGOTRI (Lexington, Massachusetts)
ABSTRACT Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker.
FILED Thursday, December 09, 2021
APPL NO 17/546480
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/704 (20130101)
A61K 31/4745 (20130101)
A61K 31/7068 (20130101)
A61K 47/61 (20170801) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096656 Henkin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Jack Henkin (Highland Park, Illinois);  Ignacio Melgar-Asensio (Chicago, Illinois)
ABSTRACT Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. The nanocarriers may comprise a drug and may be administered for localized and sustained delivery of the drug.
FILED Tuesday, December 14, 2021
APPL NO 17/550833
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 9/0051 (20130101)
A61K 38/00 (20130101)
A61K 47/61 (20170801)
A61K 47/542 (20170801)
A61K 47/6903 (20170801)
A61K 47/6921 (20170801)
A61K 47/6935 (20170801)
A61K 47/6939 (20170801) Original (OR) Class

Peptides
C07K 7/06 (20130101)
C07K 14/47 (20130101)
C07K 14/75 (20130101)
C07K 14/78 (20130101)
C07K 14/811 (20130101)
C07K 14/8121 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096658 Chien et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Wade W. Chien (Bethesda, Maryland);  Jean Bennett (Philadelphia, Pennsylvania)
ASSIGNEE(S) The United States of America, As Represented by The Secretary, Department of Health and Human Svcs. (Rockville, Maryland)
INVENTOR(S) Wade W. Chien (Bethesda, Maryland);  Jean Bennett (Philadelphia, Pennsylvania)
ABSTRACT Provided herein are adeno-associated viruses and methods for using same to treat or prevent disorders that affect the inner ear of a subject.
FILED Friday, December 20, 2019
APPL NO 17/416311
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/0075 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 2750/14122 (20130101)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096659 Laoharawee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota);  REGENXBIO Inc. (Rockville, Maryland)
ASSIGNEE(S)
INVENTOR(S) Kanut Laoharawee (Minneapolis, Minnesota);  Kelly M. Podetz-Pedersen (Chaska, Minnesota);  Karen Kozarsky (Bala Cynwyd, Pennsylvania);  R. Scott McIvor (St. Louis Park, Minnesota);  Lalitha R. Belur (St. Paul, Minnesota)
ABSTRACT A method to prevent, inhibit or treat one or more neurological symptoms associated with a central nervous system disorder, e.g. MPSI or MPSII by, for example, intrathecally, intracerebroventricularly or intravenously administering a rAAV encoding a gene product associated with the disease, e.g., administering to an adult mammal in which the gene product is absent, defective or present at a reduced level relative to a mammal without the disease.
FILED Friday, October 22, 2021
APPL NO 17/508714
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0085 (20130101)
A61K 38/47 (20130101)
A61K 38/465 (20130101)
A61K 45/06 (20130101)
A61K 48/0075 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2320/32 (20130101)
C12N 2750/14143 (20130101)

Enzymes
C12Y 301/06013 (20130101)
C12Y 302/01076 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096663 Basilion et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio)
ASSIGNEE(S)
INVENTOR(S) James Basilion (Cleveland, Ohio);  Clemens Burda (Cleveland, Ohio);  Dong Luo (Cleveland, Ohio);  Xinning Wang (Cleveland, Ohio)
ABSTRACT Prostate-specific membrane antigen (PSMA) targeted compounds having formula (I), nanoclusters formed thereof, pharmaceutical compositions comprising a plurality of these compounds, and methods for treating and detecting cancers in a subject are described herein.
FILED Tuesday, January 21, 2020
APPL NO 17/424084
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/14 (20130101)
A61K 33/242 (20190101)
A61K 41/0038 (20130101)
A61K 47/542 (20170801)
A61K 49/0423 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096706 XIE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Jingwei XIE (Omaha, Nebraska);  Guangshun WANG (Omaha, Nebraska)
ABSTRACT Nanofiber structures are provided as well as methods of use thereof and methods of making.
FILED Tuesday, January 28, 2020
APPL NO 17/425057
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 15/26 (20130101)
A61L 15/32 (20130101)
A61L 15/44 (20130101) Original (OR) Class
A61L 15/225 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/0023 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 8/14 (20130101)
D01F 8/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096714 Usas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Arvydas Usas (Pittsburgh, Pennsylvania);  Karin Payne (Pittsburgh, Pennsylvania);  Thomas Payne (Pittsburgh, Pennsylvania);  Ronald Jankowski (Pittsburgh, Pennsylvania);  Johnny Huard (Wexford, Pennsylvania)
ABSTRACT The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
FILED Tuesday, May 11, 2021
APPL NO 17/316854
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/12 (20130101)
A61K 35/38 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/54 (20130101)
A61L 27/58 (20130101)
A61L 27/365 (20130101)
A61L 27/3629 (20130101)
A61L 27/3826 (20130101)
A61L 27/3847 (20130101)
A61L 27/3895 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0652 (20130101)
C12N 5/0658 (20130101)
C12N 5/0659 (20130101)
C12N 11/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096748 El-Khatib et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Beta Bionics, Inc. (Irvine, California)
ASSIGNEE(S)
INVENTOR(S) Firas H. El-Khatib (Allston, Massachusetts);  Edward R. Damiano (Acton, Massachusetts);  Edward B. Raskin (Irvine, California);  David Chi-Wai Lim (Irvine, California);  Michael J. Rosinko (Las Vegas, Nevada);  John R. Costik (Livonia, New York)
ABSTRACT An automated blood glucose control system can provide automatic delivery of glucose control therapy to a subject and receive information about manual glucose control therapy provided to the subject. The automated blood glucose control system can indicate an amount of a bolus of medicament via a control algorithm configured to control blood glucose level in the subject. The automated blood glucose control system can indicate an amount of a manual bolus of medicament, which can be used to model a diminishment of the medicament in the subject over time based at least in part on the manual bolus of medicament.
FILED Friday, October 01, 2021
APPL NO 17/492007
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/142 (20130101)
A61M 5/172 (20130101) Original (OR) Class
A61M 5/1723 (20130101)
A61M 5/14244 (20130101)
A61M 5/14248 (20130101)
A61M 5/16831 (20130101)
A61M 2205/18 (20130101)
A61M 2205/52 (20130101)
A61M 2205/3553 (20130101)
A61M 2230/201 (20130101)

Electric Digital Data Processing
G06F 3/04847 (20130101)
G06F 3/04883 (20130101)
G06F 8/61 (20130101)
G06F 8/65 (20130101)
G06F 8/656 (20180201)
G06F 21/31 (20130101)
G06F 21/84 (20130101)
G06F 21/305 (20130101)
G06F 21/6245 (20130101)

Signalling or Calling Systems; Order Telegraphs; Alarm Systems
G08B 21/18 (20130101)
G08B 21/0453 (20130101)
G08B 25/00 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
G16H 20/17 (20180101)
G16H 40/40 (20180101)
G16H 40/60 (20180101)
G16H 40/67 (20180101)
G16H 50/30 (20180101)
G16H 80/00 (20180101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/30 (20130101)
H04L 9/088 (20130101)
H04L 63/101 (20130101)
H04L 67/34 (20130101)

Wireless Communication Networks
H04W 76/10 (20180201)
H04W 76/14 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096834 WANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Qi WANG (New York, New York);  Charles RODENKIRCH (New York, New York)
ABSTRACT Methods and devices for modifying sensory processing in a subject are provided. Aspects are directed to applying tonic vagus nerve stimulation to a subject for transient sensory processing modification. Devices for applying tonic vagus nerve stimulation when a subject is in need of sensory modification or on demand are also provided. The devices can be coupled with a prosthetic device for application to regions of the body in need of vagus nerve stimulation.
FILED Friday, December 10, 2021
APPL NO 17/547436
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36025 (20130101) Original (OR) Class
A61N 1/36031 (20170801)
A61N 1/36034 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096860 Chamanzar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Maysamreza Chamanzar (Pittsburgh, Pennsylvania);  Jay W. Reddy (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is a fully flexible photonic platform based on a high density, flexible array of ultra-compact optical waveguides composed of biocompatible polymers Parylene C and PDMS. The photonic platform features unique embedded input/output micro-mirrors that redirect light from the waveguides perpendicularly to the surface of the array for localized, patterned illumination in tissue. This architecture enables the design of a fully flexible, compact integrated photonic system to realize an implantable, wearable or on-chip photonic platform for application such as in vivo chronic optogenetic stimulation of brain activity.
FILED Monday, September 27, 2021
APPL NO 17/486351
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/067 (20210801)
A61N 5/0601 (20130101) Original (OR) Class
A61N 5/0622 (20130101)
A61N 2005/063 (20130101)
A61N 2005/0643 (20130101)
A61N 2005/0666 (20130101)

Optical Elements, Systems, or Apparatus
G02B 6/4214 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/0005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097043 Chiu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S) University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S) Daniel T. Chiu (Seattle, Washington);  Thomas Schneider (Vancouver, Canada);  Jason E. Kreutz (Marysville, Washington)
ABSTRACT Devices, systems and apparatuses for the discretization and manipulation of sample volumes are provided. Related methods are also provided.
FILED Tuesday, November 23, 2021
APPL NO 17/456208
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5027 (20130101)
B01L 3/50273 (20130101) Original (OR) Class
B01L 3/50851 (20130101)
B01L 7/52 (20130101)
B01L 2200/0605 (20130101)
B01L 2200/0642 (20130101)
B01L 2200/0673 (20130101)
B01L 2300/0803 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/0406 (20130101)
B01L 2400/0409 (20130101)
B01L 2400/0487 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/44791 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098196 YU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Regents of the University of Texas System (Austin, Texas)
ASSIGNEE(S) The Board of Regents of the University of Texas System (Austin, Texas)
INVENTOR(S) Yonghao YU (Dallas, Texas);  Chuo CHEN (Dallas, Texas);  Shuai WANG (Dallas, Texas);  Lei HAN (Dallas, Texas);  Lin YOU (Dallas, Texas)
ABSTRACT The disclosure provides PARP PROTAC molecules comprising a PARP inhibitor linked to an E3 ligase binder, and their use in treating diseases caused by aberrant PARP activation. Such PROTAC molecules produce selective degradation of one or a specific set of PARP proteins with limited effects on the protein level of other PARPs.
FILED Friday, January 31, 2020
APPL NO 17/428605
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)
A61K 47/55 (20170801)

Heterocyclic Compounds
C07D 401/14 (20130101)
C07D 417/14 (20130101)
C07D 471/06 (20130101) Original (OR) Class
C07D 487/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098210 Hurley et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Laurence Hurley (Tucson, Arizona);  Biswanath De (Tucson, Arizona);  Venkateshwar R. Chappeta (Tucson, Arizona);  Tracy A. Brooks (Tucson, Arizona);  Vijay Gokhale (Tucson, Arizona);  Cynthia Miranti (Tucson, Arizona);  Elsa Reyes Reyes (Tucson, Arizona)
ABSTRACT This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quindoline (or similar) structure which function as stabilizers of G-quadruplex (G4) formation, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer), and other conditions mediated by G4 stabilization.
FILED Wednesday, January 29, 2020
APPL NO 17/426932
CURRENT CPC
Heterocyclic Compounds
C07D 487/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098214 BENNETT et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Anton BENNETT (Wilton, Connecticut);  Gurulingappa HALLUR (Bangalore, India);  Chandregowda VENKATESHAPPA (Bangalore, India);  Athisayamani Jeyaraj DURAISWAMY (Bangalore, India);  Rama Kishore V.P. PUTTA (Bangalore, India)
ABSTRACT The present invention provides compounds and methods for treating MKP5 modulated disease. In certain embodiments, the MKP5 modulated disease is a fibrotic disease.
FILED Thursday, January 30, 2020
APPL NO 17/426762
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/519 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)

Heterocyclic Compounds
C07D 495/06 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5061 (20130101)
G01N 2333/912 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098234 SUSIN PIRES et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Ivan SUSIN PIRES (Piracicaba, Sao Paulo, Brazil);  Andre PALMER (Bexley, Ohio);  Donald BELCHER (Columbus, Ohio)
ABSTRACT Provided herein are methods for purifying proteins from mixtures of proteins using ultrafiltration, such as tangential-flow filtration (TFF). Provided herein are methods for isolating an apoprotein from a protein solution comprising a conjugated protein, wherein the conjugated protein comprises the apoprotein and a hydrophobic ligand associated with the apoprotein.
FILED Friday, January 31, 2020
APPL NO 17/427547
CURRENT CPC
Peptides
C07K 1/34 (20130101) Original (OR) Class
C07K 1/36 (20130101)
C07K 14/775 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098242 ZHU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Xiaoping ZHU (Clarksville, Maryland);  Weizhong LI (College Park, Maryland);  Tao WANG (Ellicott City, Maryland)
ABSTRACT Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-CoV-2 or at risk of being exposed to SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein.
FILED Friday, February 26, 2021
APPL NO 17/187214
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098243 Deverman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
NIH Office of the Director (NIHOD)
National Institute of Mental Health (NIMH)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Benjamin E. Deverman (Pasadena, California);  Paul H. Patterson (Altadena, California);  Viviana Gradinaru (La Cañada Flintridge, California)
ABSTRACT Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
FILED Friday, August 13, 2021
APPL NO 17/402317
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 38/47 (20130101)
A61K 38/50 (20130101)
A61K 38/1709 (20130101)
A61K 38/2093 (20130101)
A61K 38/4813 (20130101)
A61K 39/3955 (20130101)
A61K 48/005 (20130101)
A61K 48/0058 (20130101)

Peptides
C07K 7/06 (20130101)
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101)
C12N 15/1068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098244 Kong et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Leopold Kong (Bethesda, Maryland);  Ian A. Wilson (La Jolla, California);  Natalia De Val (San Diego, California);  Andrew B. Ward (San Diego, California);  Dennis Burton (La Jolla, California);  Linling He (San Diego, California);  Jiang Zhu (San Diego, California)
ABSTRACT The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
FILED Thursday, December 16, 2021
APPL NO 17/553070
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/21 (20130101)
A61K 47/6929 (20170801)

Peptides
C07K 14/005 (20130101)
C07K 14/162 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2740/16122 (20130101)
C12N 2740/16134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098248 Chilkoti et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ashutosh Chilkoti (Durham, North Carolina);  Nicholas Tang (Durham, North Carolina);  Garrett Kelly (Durham, North Carolina)
ABSTRACT Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein.
FILED Thursday, September 16, 2021
APPL NO 17/477192
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/65 (20170801)

Peptides
C07K 14/31 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098250 CHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Zibo CHEN (Seattle, Washington);  Scott BOYKEN (Seattle, Washington);  Sherry BERMEO (Seattle, Washington);  Robert A. LANGAN (Seattle, Washington);  David BAKER (Seattle, Washington)
ABSTRACT Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.
FILED Friday, October 15, 2021
APPL NO 17/502485
CURRENT CPC
Peptides
C07K 14/435 (20130101) Original (OR) Class
C07K 2319/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/53 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098251 Fischer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts);  THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts);  THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
INVENTOR(S) Eric Fischer (Newton, Massachusetts);  Benjamin L. Ebert (Brookline, Massachusetts);  Max Jan (Somerville, Massachusetts);  Radoslaw Nowak (Boston, Massachusetts)
ABSTRACT Described herein are compositions and methods for modulating protein abundance in a target-specific manner via degron tags.
FILED Wednesday, December 18, 2019
APPL NO 17/413859
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4439 (20130101)
A61K 35/17 (20130101)
A61K 38/08 (20130101)
A61K 38/10 (20130101)
A61K 38/1709 (20130101)
A61K 39/3955 (20130101)
A61K 48/00 (20130101)

Peptides
C07K 7/06 (20130101)
C07K 7/08 (20130101)
C07K 14/47 (20130101) Original (OR) Class
C07K 16/2803 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
C07K 2319/30 (20130101)
C07K 2319/33 (20130101)
C07K 2319/95 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098258 Hudalla et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S) Gregory Allan Hudalla (Gainesville, Florida);  Margaret Mary Fettis (Northborough, Massachusetts)
ABSTRACT Described herein are Galectin-1/Galectin-3 multivalent protein complexes and uses thereof. In some aspects, Galectin-1/1 Galectin-3 multivalent protein complexes are useful to treat inflammatory conditions in a subject.
FILED Friday, February 28, 2020
APPL NO 17/434616
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)

Peptides
C07K 14/4726 (20130101) Original (OR) Class
C07K 2319/73 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098260 Walensky et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Loren D. Walensky (Newton, Massachusetts);  Michelle L. Stewart (Cambridge, Massachusetts);  Lauren Barclay (Brookline, Massachusetts)
ABSTRACT Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating BAX protein, and/or its close homologues BAK and BOK, and/or other physiological BH4 targets. Also provided are compositions containing these polypeptides and methods of treating cytotoxic diseases that include administering to a subject one of the polypeptides.
FILED Friday, April 16, 2021
APPL NO 17/232678
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/08 (20130101)
A61K 9/0019 (20130101)
A61K 38/00 (20130101)
A61K 38/1761 (20130101)
A61K 45/06 (20130101)
A61K 49/0008 (20130101)

Peptides
C07K 14/4747 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098261 LEE et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Jungmin LEE (BOSTON, Massachusetts);  Jeffrey Charles WAY (Cambridge, Massachusetts)
ABSTRACT The technology described herein is directed to engineered polypeptides comprising an anti-GYPA antibody reagent and an EPO polypeptide. Further provided herein are methods of treating anemia by administering said polypeptides.
FILED Thursday, December 19, 2019
APPL NO 17/312523
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/06 (20180101)

Peptides
C07K 14/505 (20130101) Original (OR) Class
C07K 16/2896 (20130101)
C07K 2319/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098268 RHODE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) ALTOR BIOSCIENCE, LLC (Miramar, Florida);  The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Peter RHODE (Miami, Florida);  Mark CONNORS (Bethesda, Maryland);  Stephen MIGUELES (Washington, District of Columbia)
ABSTRACT Engineered TCR molecules specific to retroviral peptide/HLA complexes guide direct killing and/or enable robust immune responses against HIV infected cells. In a first aspect, a TCR fusion polypeptide comprises a TCR variable alpha (Vα) domain, a TCR variable beta domain (Vβ) and a TCR constant region domain (C), wherein the TCR fusion polypeptide is specific for HIV peptides.
FILED Wednesday, January 15, 2020
APPL NO 17/422523
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Peptides
C07K 14/7051 (20130101) Original (OR) Class
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098284 Bu et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USUHS)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Wei Bu (Potomac, Maryland);  Masaru Kanekiyo (Chevy Chase, Maryland);  Michael Gordon Joyce (Washington, District of Columbia);  Jeffrey I. Cohen (Silver Spring, Maryland)
ABSTRACT Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus infection in mammals, and methods of using those compositions of matter for the same are disclosed. Also disclosed are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
FILED Thursday, December 16, 2021
APPL NO 17/553139
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/05 (20130101)
C07K 16/085 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098286 Kwong et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Peter Kwong (Washington, District of Columbia);  Young Do Kwon (Kensington, Maryland);  Ivelin Georgiev (Nashville, Tennessee);  Gilad Ofek (Gaithersburg, Maryland);  Baoshan Zhang (Bethesda, Maryland);  Krisha McKee (Columbia, Maryland);  John Mascola (Rockville, Maryland);  Mark Connors (Bethesda, Maryland);  Gwo-Yu Chuang (Rockville, Maryland);  Sijy O'Dell (Silver Spring, Maryland);  Robert Bailer (Adamstown, Maryland);  Mark Louder (Mt. Airy, Maryland);  Mangaiarkarasi Asokan (Rockville, Maryland);  Richard Schwartz (Bethesda, Maryland);  Jonathan Cooper (Arlington, Virginia);  Kevin Carlton (Gaithersburg, Maryland);  Michael Bender (Washington, District of Columbia);  Amarendra Pegu (Potomac, Maryland);  Lawrence Shapiro (New York, New York);  Tatyana Gindin (New York, New York);  Lisa Kueltzo (Gaithersburg, Maryland)
ABSTRACT Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
FILED Tuesday, December 14, 2021
APPL NO 17/551066
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)

Peptides
C07K 16/1063 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/31 (20130101)
C07K 2317/33 (20130101)
C07K 2317/52 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/94 (20130101)
C07K 2317/565 (20130101)
C07K 2317/567 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098293 Muir et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Tom W. Muir (Princeton, New Jersey);  Miquel Vila-Perello (Princeton, New Jersey);  Zhihua Liu (Plainsborough, New Jersey);  Neel H. Shah (Princeton, New Jersey)
ABSTRACT Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
FILED Friday, October 01, 2021
APPL NO 17/491729
CURRENT CPC
Peptides
C07K 14/195 (20130101)
C07K 16/18 (20130101) Original (OR) Class
C07K 2319/50 (20130101)
C07K 2319/92 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/93 (20130101)
C12N 15/62 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/02 (20130101)
C12P 21/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098294 Daugherty et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  CytomX Therapeutics, Inc. (South San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Patrick Sean Daugherty (Santa Barbara, California);  Nancy Stagliano (Santa Barbara, California);  Jerry Thomas (Goleta, California);  Kathryn Kamath (Santa Barbara, California);  James W. West (Santa Barbara, California);  Sanjay Khare (Newbury Park, California);  Jason Sagert (Santa Barbara, California)
ABSTRACT The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
FILED Friday, April 30, 2021
APPL NO 17/245713
CURRENT CPC
Peptides
C07K 16/22 (20130101) Original (OR) Class
C07K 16/24 (20130101)
C07K 16/42 (20130101)
C07K 16/2818 (20130101)
C07K 16/2836 (20130101)
C07K 2317/34 (20130101)
C07K 2317/622 (20130101)
C07K 2319/00 (20130101)
C07K 2319/30 (20130101)
C07K 2319/50 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1034 (20130101)
C12N 15/1044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098322 Weiskopf et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of trustees of the Leland Stanford Junior University (Stanford, California);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Kipp Andrew Weiskopf (Brookline, Massachusetts);  Kim J. Hasenkrug (Victor, Montana);  Cheryl A. Stoddart (Pacifica, California);  Joseph McCrary McCune (San Francisco, California);  Irving L. Weissman (Stanford, California)
ABSTRACT Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRPα on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.
FILED Tuesday, December 14, 2021
APPL NO 17/550881
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1774 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/2803 (20130101)
C07K 16/2896 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098323 Ho et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America,As Represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as Represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Mitchell Ho (Urbana, Maryland);  Nan Li (Laurel, Maryland);  Jiajia Pan (Rockville, Maryland)
ABSTRACT Monoclonal antibodies that specifically bind glypican-1 (GPC1) are described. Chimeric antigen receptor (CAR) T cells, immunotoxins and other antibody conjugates based on the GPC1-specific antibodies are also described. The disclosed CAR T cells, immunotoxins, GPC1-specific antibodies and conjugates thereof can be used, for example, in the diagnosis or treatment of GPC1-positive pancreatic cancer and other cancers.
FILED Wednesday, January 15, 2020
APPL NO 17/422609
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6829 (20170801)
A61K 47/6929 (20170801)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/04 (20180101)

Peptides
C07K 14/4725 (20130101)
C07K 16/303 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098540 Huang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Po-Hsun Huang (Quincy, Massachusetts);  Cullen Richard Buie (Cambridge, Massachusetts);  Sijie Chen (Cambridge, Massachusetts)
ABSTRACT An electroporation assembly for interfacing with a liquid handling system includes at least two electrically conductive layer components and a channel layer component. The channel layer component is configured to be removably disposed between the electrically conductive layer components. The electrically conductive layer components and the channel layer component define a plurality of parallel electroporation flow paths in an assembled state. An electroporation system includes an electroporation assembly and a cell collection unit. The electroporation assembly is configured to direct a flow of a cell sample to the cell collection unit.
FILED Friday, July 30, 2021
APPL NO 17/390435
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 35/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098548 Yarmush et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Martin Yarmush (Newton, Massachusetts);  Basak E. Uygun (Cambridge, Massachusetts);  Korkut Uygun (Boston, Massachusetts);  Maria-Louisa Izamis (Boston, Massachusetts);  Alejandro Soto-Gutierrez (Boston, Massachusetts);  Herman Tolboom (Zurich, Switzerland);  Hiroshi Yagi (Brookline, Massachusetts);  Carley Shulman (Sudbury, Massachusetts);  Jack Milwid (Denver, Colorado)
ABSTRACT One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
FILED Friday, October 01, 2021
APPL NO 17/449762
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/021 (20130101)
A01N 1/0247 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/407 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 1/14 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/067 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098561 Gersbach et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Charles A. Gersbach (Chapel Hill, North Carolina);  Isaac Hilton (Houston, Texas)
ABSTRACT Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
FILED Friday, September 10, 2021
APPL NO 17/471935
CURRENT CPC
Peptides
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 9/1029 (20130101)
C12N 15/11 (20130101)
C12N 15/63 (20130101)
C12N 15/85 (20130101)
C12N 2310/20 (20170501)

Enzymes
C12Y 203/01048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098599 JOHNSTON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Christopher JOHNSTON (Seattle, Washington);  Sean COTTON (Cambridge, Massachusetts)
ABSTRACT Embodiments include engineered minicircle-producing bacterium with differential methylation capability, as well as kits and compositions comprising the bacterium. Further described are methods of using of the bacterium for producing differentially methylated minicircle DNA, and for improving transformation efficiency of exogenous DNA in intractable bacteria.
FILED Thursday, February 06, 2020
APPL NO 17/428585
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/205 (20210501)
C12N 9/1007 (20130101)
C12N 15/70 (20130101) Original (OR) Class
C12N 15/74 (20130101)

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/19 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098613 Kiem et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
INVENTOR(S) Hans-Peter Kiem (Seattle, Washington);  Olivier Humbert (Seattle, Washington);  Roland B. Walter (Seattle, Washington)
ABSTRACT Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells and targeting non-therapeutic cells with an anti-CD33 therapy. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject.
FILED Thursday, September 12, 2019
APPL NO 17/276105
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)
A61K 35/28 (20130101)
A61K 39/3955 (20130101)
A61K 47/6849 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/04 (20180101)

Peptides
C07K 16/2803 (20130101)
C07K 2317/31 (20130101)
C07K 2317/565 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
C07K 2319/30 (20130101)
C07K 2319/33 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 15/1138 (20130101)
C12N 2310/14 (20130101)
C12N 2310/122 (20130101)
C12N 2310/531 (20130101)
C12N 2320/31 (20130101)
C12N 2740/15043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098620 CHOUDHARY et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amit CHOUDHARY (Boston, Massachusetts);  Donghyun LIM (Cambridge, Massachusetts);  Praveen KOKKONDA (Boston, Massachusetts);  Sophia LAI (Boston, Massachusetts)
ABSTRACT The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.
FILED Friday, July 09, 2021
APPL NO 17/372406
CURRENT CPC
Heterocyclic Compounds
C07D 239/46 (20130101)
C07D 409/10 (20130101)
C07D 487/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/85 (20130101)
C12N 15/115 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098635 Lindsay et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S) Stuart Lindsay (Phoenix, Arizona);  Bintian Zhang (Tempe, Arizona);  Hanqing Deng (Tempe, Arizona)
ABSTRACT A universal connection system for assembling and electrically connecting proteins to make bioelectronic detectors and logic circuits, exploiting the electronic properties of ligand-receptor interactions and the quasi metallic properties of protein interiors.
FILED Thursday, January 30, 2020
APPL NO 17/426893
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/004 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098640 Scharfe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, None)
INVENTOR(S) Curt Scharfe (North Haven, Connecticut);  Peidong Shen (Union City, California);  Ronald W. Davis (Palo Alto, California)
ABSTRACT Systems and methods of performing multiplex PCR on low and ultra-low quantities of starting template using custom primer sequences having a homotag. In some embodiments, these primers are capable of amplifying over 100 targets simultaneously and/or are capable of amplifying targets from low quantities of starting template. Along with these primers, sequencing methods are provided capable of sequencing the targets from numerous individuals, simultaneously. Additionally, methods for analyzing the sequencing results to advance treating an individual are provided.
FILED Wednesday, September 11, 2019
APPL NO 17/275566
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098642 ZHANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) William Marsh Rice University (Houston, Texas)
ASSIGNEE(S) William Marsh Rice University (Houston, Texas)
INVENTOR(S) David ZHANG (Houston, Texas);  Peng DAI (Houston, Texas);  Ruojia WU (Houston, Texas)
ABSTRACT Provided herein are methods of quantitative amplicon sequencing, for labeling each strand of targeted genomic loci in a DNA sample with an oligonucleotide barcode sequence by polymerase chain reaction, and amplifying the genomic region(s) for high-throughput sequencing. The methods can be used for the simultaneous detection of copy number variation (CNV) in a set of genes of interest, by quantifying the frequency of extra copies of each gene. In addition, these methods provide for the quantitation of the allele ratio of different genetic identities for targeted genomic loci using multiplexed PCR. In addition, these methods provide for the detection of mutations and quantitation of the variant allele frequency.
FILED Thursday, January 02, 2020
APPL NO 17/420476
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class
C12Q 1/6851 (20130101)
C12Q 1/6853 (20130101)
C12Q 1/6858 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098643 Krusemark et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Casey J. Krusemark (West Lafayette, Indiana);  Bo Cai (Lafayette, Indiana)
ABSTRACT The present application relates to an assay method using affinity crosslinking of DNA-linked ligands to proteins to enable small molecule screening and determination of apparent affinity constants of ligands to the proteins. This method has been applied to determine 96 compounds' dissociation constants to a protein target simultaneously, and directly determine a compound's IC50 against five protein targets concurrently in crude cell lysates. Additionally, this approach was used to screen a Library of Pharmacologically Active Compounds (LOPAC) library against dihydrofolate reductase (eDHFR), enabling the discovery of a novel eDHFR inhibitor (IC50=7.9 μM). An assay kit and the method of uses are within the scope of this disclosure.
FILED Monday, September 13, 2021
APPL NO 17/472756
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/485 (20130101)
C12Q 1/686 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098648 McNamara et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
ASSIGNEE(S) UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa)
INVENTOR(S) James O. McNamara (Iowa City, Iowa);  Katie R. Flenker (Iowa City, Iowa);  Hyeon Kim (Iowa City, Iowa);  Alexander R. Howswill (Iowa City, Iowa);  Frank J. Hernandez (Iowa City, Iowa);  Mark Behlke (Coralville, Iowa);  Lingyan Huang (Coralville, Iowa);  Richard Owczarzy (Coralville, Iowa);  Elliott Burghardt (Iowa City, Iowa);  Karen Clark (Iowa City, Iowa)
ABSTRACT The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
FILED Tuesday, October 05, 2021
APPL NO 17/494626
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0054 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/02 (20130101)
C07H 21/04 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101) Original (OR) Class
C12Q 1/701 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 33/581 (20130101)
G01N 2021/6432 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098660 Rank et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) Pacific Biosciences of California, Inc. (Menlo Park, California)
ASSIGNEE(S)
INVENTOR(S) David R. Rank (Pacific Grove, California);  Jeffery Wegener (Cupertino, California);  Jonas Korlach (Camas, Washington);  Daniel Roitman (Menlo Park, California);  Yue Xu (Fremont, California);  John Lyle (Fremont, California);  Stephen Turner (Eugene, Oregon);  Paul Peluso (Newark, California);  Geoff Otto (Brookline, Massachusetts);  Ron L. Cicero (Palo Alto, California)
ABSTRACT Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
FILED Monday, October 18, 2021
APPL NO 17/504115
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/0046 (20130101)
B01J 2219/0045 (20130101)
B01J 2219/0061 (20130101)
B01J 2219/00427 (20130101)
B01J 2219/00605 (20130101)
B01J 2219/00612 (20130101)
B01J 2219/00617 (20130101)
B01J 2219/00626 (20130101)
B01J 2219/00635 (20130101)
B01J 2219/00637 (20130101)
B01J 2219/00639 (20130101)
B01J 2219/00659 (20130101)
B01J 2219/00711 (20130101)
B01J 2219/00722 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)
B82Y 30/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6837 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class

Technical Subjects Covered by Former US Classification
Y10T 29/49002 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098663 Tan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S) University of South Carolina (Columbia, South Carolina)
INVENTOR(S) Wenbin Tan (Columbia, South Carolina);  Elaine G. Taine (Columbia, South Carolina)
ABSTRACT Described herein are biomarkers that have shown significantly increased expression levels in malformed blood vessels as compared to normal vessels, as well as methods of use employing the novel biomarkers to provide early diagnosis of congenital vascular malformations as well as treatment for same.
FILED Wednesday, July 28, 2021
APPL NO 17/386733
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101) Original (OR) Class
C12Q 2600/112 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098683 Higginson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Daniel Smith Higginson (Tenafly, New Jersey);  Rama Rao Damerla (Manipal, India)
ABSTRACT The present invention provides methods and compositions for the detection of HPV DNA in patient samples with high sensitivity and specificity. Such methods are useful in screening for HPV-associated malignancies. In some embodiments the present invention provides methods and compositions for the detection of HPV16, HPV33 and/or HP VI 8 DNA. In some embodiments the present invention provides methods and compositions for the detection of HPV DNA from squamous cell carcinomas, such as oropharyngeal squamous cell carcinomas and anal squamous cell carcinomas.
FILED Tuesday, September 10, 2019
APPL NO 17/196631
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/708 (20130101) Original (OR) Class
C12Q 1/6886 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/118 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099675 CHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Xiahui CHEN (Mesa, Arizona);  Shoukai KANG (Seattle, Washington);  Md Ashif IKBAL (Tempe, Arizona);  Zhi ZHAO (Mesa, Arizona);  Liangcai GU (Seattle, Washington);  Chao WANG (Chandler, Arizona)
ABSTRACT Provided herein are methods of detecting Ebola virus in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first or second epitopes of glycoproteins, such as secreted glycoproteins (sGPs) from the Ebola virus under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first or second epitopes of the glycoproteins from the Ebola virus in the sample to produce bound glycoproteins. The methods also include detecting the glycoproteins from the Ebola virus when aggregations of the bound glycoproteins form with one another. Related reaction mixtures, devices, kits, and systems are also provided.
FILED Wednesday, September 29, 2021
APPL NO 17/489273
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/78 (20130101)
G01N 33/54326 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101) Original (OR) Class
G01N 2333/08 (20130101)
G01N 2469/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099676 Fong et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Lawrence H. Fong (Palo Alto, California);  Serena Kwek MacPhee (Oakland, California)
ABSTRACT The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides diagnostic assays involving detecting the presence and/or level in biological sample of an antibody specific for a disease-associated antigen.
FILED Monday, May 24, 2021
APPL NO 17/328364
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101)
A61K 39/001193 (20180801)
A61K 39/39558 (20130101)

Peptides
C07K 14/705 (20130101)
C07K 14/4748 (20130101)
C07K 16/30 (20130101)
C07K 2317/24 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/564 (20130101)
G01N 33/57434 (20130101) Original (OR) Class
G01N 2800/042 (20130101)
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
G01N 2800/104 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099683 Steyaert et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) VIB VZW (Gent, Belgium);  Vrije Universiteit Brussel (Brussels, Belgium);  The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) Jan Steyaert (Beersel, Belgium);  Els Pardon (Wezemaal, Belgium);  Soren G.F. Rasmussen (Frederiksberg, Denmark);  Juan Jose Fung (San Jose, California);  Brian Kobilka (Palo Alto, California);  Toon Laeremans (Dworp, Belgium)
ABSTRACT The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
FILED Thursday, October 21, 2021
APPL NO 17/507492
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/705 (20130101)
C07K 14/723 (20130101)
C07K 16/28 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/20 (20130101)
G01N 33/68 (20130101)
G01N 33/566 (20130101)
G01N 33/6857 (20130101)
G01N 33/6872 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101530 TRAYANOVA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Natalia TRAYANOVA (Baltimore, Maryland);  Rheeda ALI (Baltimore, Maryland);  Julie SHADE (Baltimore, Maryland)
ABSTRACT A device may receive images of a patient, and may perform segmentation of surfaces on the images to create a 3D model. The device may identify normal tissue regions and atrial fibrosis (AF) regions in the 3D model, and may divide the 3D model into the normal tissue regions and the AF regions. The device may assign first cell and tissue properties to the normal tissue regions, and may assign second cell and tissue properties to the AF regions. The device may perform simulations on the normal tissue regions and the AD regions, based on the first and second cell and tissue properties, to generate simulation results, and may extract first features from the simulation results. The device may extract second features from the images, and may process the first and second features, with a model, to select a feature that is predictive of atrial fibrillation recurrence.
FILED Friday, January 24, 2020
APPL NO 17/425540
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101) Original (OR) Class
G06T 2207/10088 (20130101)
G06T 2207/20021 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30048 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/20 (20180101)
G16H 30/40 (20180101)
G16H 50/20 (20180101)
G16H 50/50 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101572 DEJONGH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) ProtonVDA LLC (Naperville, Illinois)
ASSIGNEE(S)
INVENTOR(S) Don Frederic DEJONGH (Batavia, Illinois);  Ethan Alan DEJONGH (Aurora, Illinois)
ABSTRACT Described herein is a system for 3D proton imaging encompassing both proton radiography (pRad) and proton CT (pCT). The disclosed system can reduce range uncertainties, while providing a fast and efficient check of patient set up and integrated range along a beam's eye view just before treatment. The disclosed system provides a complete solution to the range inaccuracy problem in proton therapy, substantially reducing the uncertainties of treatment planning by directly measuring relative stopping power without being affected by image artifacts and with much lower dose to the patient than comparable x-ray images. Also described herein is a proton imaging algorithm for prompt iterative 3D pCT image reconstruction, where each iteration is fast and efficient, and the number of iterations is minimized. The method offers a unique solution that optimally fits different protons and does not depend on the starting point for the first iteration.
FILED Monday, September 27, 2021
APPL NO 17/486734
CURRENT CPC
Image Data Processing or Generation, in General
G06T 11/005 (20130101) Original (OR) Class
G06T 2210/41 (20130101)
G06T 2211/424 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20220095607 Uygun et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mustafa Korkut Uygun (Newton, Massachusetts);  Laura Burlage (Amsterdam, Netherlands);  Shannon N. Tessier (Framingham, Massachusetts);  Curtis L. Cetrulo (Cohasset, Massachusetts);  Alexandre G. Lellouch (Harrison, New York);  Reinier Johan De Vries (Boston, Massachusetts);  Mehmet Toner (Charlestown, Massachusetts)
ABSTRACT This disclosure relates to subnormothermic machine perfusion formulations for ex vivo preservation of allografts, and methods of use thereof.
FILED Wednesday, February 05, 2020
APPL NO 17/428593
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
A01N 1/0226 (20130101)
A01N 1/0247 (20130101)
A01N 1/0284 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096058 Harshman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sean Harshman (Fairborn, Ohio);  Kraig Strayer (Fairborn, Ohio);  Rhonda Pitsch (Springfield, Ohio)
ABSTRACT A system and method for collecting sweat for analytical evaluation over a period of time is disclosed. The system is configured so that discrete samples of sweat obtained during certain time intervals during the period of time can be segregated for analysis. The system includes a sweat collecting device that has a main body and a length of sweat collecting tubing that extends outward from a bore in the main body. A receptacle for collecting sweat, which may be in the form of a microfuge tube having a lid, is removably joined to the free end of the sweat collector tubing. The method includes attaching the sweat collection device over an area of a person's skin and collecting sweat from the person's skin using the sweat collection device. The sweat travels into the sweat collector tubing and then into the receptacle. During the period of time, when the desired sample has been collected, the receptacle can be removed and replaced with additional receptacles for collecting additional samples.
FILED Tuesday, May 25, 2021
APPL NO 17/329239
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/6824 (20130101)
A61B 5/6831 (20130101)
A61B 5/14517 (20130101)
A61B 10/0064 (20130101) Original (OR) Class
A61B 2560/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096059 Harshman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Sean Harshman (Fairborn, Ohio);  Anthony Qualley (Washington TWP, Ohio);  Amanda Bowman (Miamisburg, Ohio);  Kraig Strayer (Fairborn, Ohio);  Rhonda Pitsch (Springfield, Ohio);  Michael Brothers (Lebanon, Ohio)
ABSTRACT Systems and methods for continuous real-time sweat sampling and analysis are disclosed. In one case, a sweat collection device and method of using the same are provided. The sweat collecting device has a main body with a sweat-collecting surface that is placed adjacent the person's skin. A sweat collecting tube is provided. The first end of the sweat collecting tube is joined to a bore in the main body of the device and the second end extends outward therefrom. In another case, a sweat collection article and method of collecting sweat from a person's skin using the sweat collection article are provided. The sweat collection article includes: a sweat collecting tube placed adjacent to the person's skin, and at least one piece of flexible material that has an adhesive that adheres the article to the person's skin and is positioned to overlie one end of the tube. In both cases, the second end of the sweat collecting tube is in fluid communication with an instrument such as a mass spectrometer that analyzes the sweat on a real-time basis. The systems and methods may further include a device for removing salt from the sweat that is arranged so that the sweat is transported to the device prior to being transported to the instrument for analyzing the sweat.
FILED Tuesday, May 25, 2021
APPL NO 17/329252
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/443 (20130101)
A61B 5/4266 (20130101)
A61B 5/6824 (20130101)
A61B 5/6831 (20130101)
A61B 10/0064 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096169 Kabuye et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Ernest Kabuye (Pittsburgh, Pennsylvania);  Philip LeDuc (Wexford, Pennsylvania);  Jonathan Cagan (Pittsburgh, Pennsylvania);  Carmel Majidi (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is system, including a hand-held tool, for example, a surgical scalpel, integrated with a 9 degree-of-freedom inertial measurement unit and a method for tracking the location of the hand-held instrument during manual or robotically-assisted procedures. The system and method has application in the surgical field, wherein instrumented surgical instruments may be precisely tracked throughout a surgical procedure.
FILED Monday, September 27, 2021
APPL NO 17/486419
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/3211 (20130101)
A61B 34/10 (20160201)
A61B 34/20 (20160201) Original (OR) Class
A61B 34/30 (20160201)
A61B 2017/00526 (20130101)
A61B 2034/2074 (20160201)
A61B 2562/12 (20130101)
A61B 2562/028 (20130101)
A61B 2562/166 (20130101)
A61B 2562/0219 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096373 Yee et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Albert Fan Yee (Irvine, California);  Xin Fu (Oakland, California);  Sara Elizabeth Heedy (San Clemente, California)
ABSTRACT A drug-loaded, flexible and transparent composite material for use in bandages and bandage contact lenses to topically administer a medication in a sustained and effective way is described, as well as methods of fabrication and use thereof. The composite material comprises drug carrying porous nanoparticles embedded within a transparent, flexible polymeric matrix and, when applied as a bandage, provides topical drug delivery to a tissue, while protecting it from the environment, yet allowing facile examination due to transparency.
FILED Monday, August 16, 2021
APPL NO 17/403709
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0051 (20130101) Original (OR) Class
A61K 9/5115 (20130101)
A61K 9/5161 (20130101)
A61K 31/506 (20130101)
A61K 31/7048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096411 Bening et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Sarah Bening (Cambridge, Massachusetts);  Meagan Hamblin (Cambridge, Massachusetts);  Ian Andrews (Cambridge, Massachusetts);  Allison Lopatkin (Cambridge, Massachusetts);  James Collins (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides compositions and methods capable of potentiating the effects of antibiotics against bacterial infections that either have developed, or that possess the potential to develop, antibiotic tolerance. Methods of sensitizing antibiotic tolerant bacteria to antibiotics, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at antibiotic tolerant bacteria are also provided.
FILED Thursday, January 23, 2020
APPL NO 17/425438
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/46 (20130101)
A61K 31/198 (20130101) Original (OR) Class
A61K 31/407 (20130101)
A61K 31/424 (20130101)
A61K 31/431 (20130101)
A61K 31/546 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096576 Regeimbal et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of the Navy (DON)
APPLICANT(S) James M Regeimbal (Washington's Crossing, Pennsylvania);  Stuart D. Tyner (Great Falls, Virginia)
ASSIGNEE(S) United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland);  United States of America as Represented by the Secretary of the Army (Silver Spring, Maryland)
INVENTOR(S) James M Regeimbal (Washington's Crossing, Pennsylvania);  Stuart D. Tyner (Great Falls, Virginia)
ABSTRACT The subject matter of the instant invention relates to methods of enhancing harvesting of phages against a targeted host bacteria, as well as methods of identifying phages likely to have an enhanced propensity to infect and kill an infectious pathogenic bacteria in vivo, from samples comprising phages. The invention also relates to phage libraries, pharmaceutical compositions, methods of treatment, and phage-based diagnostic methods and methods of detecting bacteria related thereto.
FILED Tuesday, December 07, 2021
APPL NO 17/544733
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/76 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2795/00032 (20130101)
C12N 2795/00051 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096618 Hazlett et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) ALBANY MEDICAL COLLEGE (Albany, New York)
ASSIGNEE(S) ALBANY MEDICAL COLLEGE (Albany, New York)
INVENTOR(S) Karsten Hazlett (East Berne, New York);  Kristen M. Tummillo (Union, New Jersey);  Edmund J. Gosselin (Glenmont, New York)
ABSTRACT An approach for modifying multiple types of bacteria to produce surface modifications that enhance the immunologic response when used as a vaccine. A series of plasmids (pYF, pYFC, pYFP, pSF, pSPF, and pSCF) may be used to transform bacteria which then produce surface-exposed ligands that bind to complement receptors on antigen presenting cells. When modified bacteria are used as a vaccine, the vaccine recipients produce significantly higher titers of specific antibodies and are better protected against challenges from the disease-causing bacteria.
FILED Tuesday, September 29, 2020
APPL NO 17/036526
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/164 (20130101)
A61K 38/1725 (20130101)
A61K 39/02 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/87 (20130101)
C12N 2310/3517 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096642 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Creighton University (Omaha, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Santanu Hati (Omaha, Nebraska);  Marisa Laura Zallocchi (Omaha, Nebraska);  Robert Hazlitt (Boulder, Colorado);  Jaeki Min (Memphis, Tennessee)
ABSTRACT Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.
FILED Tuesday, September 28, 2021
APPL NO 17/488080
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/55 (20170801) Original (OR) Class
A61K 47/545 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097042 Landers et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) James P. Landers (Charlottesville, Virginia);  Jacquelyn A. DuVall (Raleigh, North Carolina);  Delphine Le Roux (Barboursville, Virginia);  Brian Root (Barboursville, Virginia);  Daniel Mills (Charlottesville, Virginia);  Daniel A. Nelson (Charlottesville, Virginia);  An-chi Tsuei (Charlottesville, Virginia);  Brandon L. Thompson (Charlottesville, Virginia);  Jingyi Li (Charlottesville, Virginia);  Christopher Birch (Charlottescille, Virginia)
ABSTRACT A method to extract, amplify and separate nucleic acid in a microfluidic device having a plurality of chambers and channels can include a) introducing cells having nucleic acid to a first chamber of the microfluidic device and subjecting the cells in the first chamber to conditions that lyse the cells. The method can further include b) subjecting the first chamber to centrifugal force, thereby allowing the lysate or a portion thereof having nucleic acid to be distributed to a second chamber through a first channel in the microfluidic device. The method can also include c) combining the lysate or the portion thereof and reagents for amplification of the nucleic acid, thereby providing a second mixture. The method can also include d) subjecting the second chamber to centrifugal force, thereby allowing gas to be expelled from the second mixture.
FILED Tuesday, September 07, 2021
APPL NO 17/447015
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101) Original (OR) Class
B01L 3/502753 (20130101)
B01L 7/52 (20130101)
B01L 2200/10 (20130101)
B01L 2200/12 (20130101)
B01L 2200/16 (20130101)
B01L 2200/0621 (20130101)
B01L 2200/0647 (20130101)
B01L 2200/0684 (20130101)
B01L 2300/0803 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0887 (20130101)
B01L 2300/1822 (20130101)
B01L 2300/1844 (20130101)
B01L 2400/0409 (20130101)
B01L 2400/0421 (20130101)
B01L 2400/0424 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/00 (20130101)
G01N 21/07 (20130101)
G01N 27/447 (20130101)
G01N 27/44791 (20130101)
G01N 2201/064 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097066 Han et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
APPLICANT(S) THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
ASSIGNEE(S)
INVENTOR(S) Arum Han (College Station, Texas);  Adrian Guzman (College Station, Texas);  Han Zhang (College Station, Texas);  Jose Wippold (College Station, Texas);  Jing Dai (College Station, Texas)
ABSTRACT A combination micro/macro-fluidic analysis system with one or more of a droplet transition unit, a droplet cleaving unit, a droplet synchronization, and a merging unit to enable highly efficient complex droplet microfluidic assays.
FILED Friday, April 23, 2021
APPL NO 17/239456
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502784 (20130101) Original (OR) Class
B01L 2200/12 (20130101)
B01L 2200/16 (20130101)
B01L 2200/027 (20130101)
B01L 2200/0647 (20130101)
B01L 2400/086 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097072 GLEZER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Meso Scale Technologies, LLC. (Rockville, Maryland)
ASSIGNEE(S)
INVENTOR(S) Eli N. GLEZER (Del Mar, California);  Bandele JEFFREY-COKER (Darnestown, Maryland);  Kenneth PAGE (Germantown, Maryland);  Sandor KOVACS (Middletown, Delaware);  Sudeep KUMAR (Gaithersburg, Maryland);  Kristian ROTH (Germantown, Maryland)
ABSTRACT Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
FILED Friday, October 01, 2021
APPL NO 17/492207
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502 (20130101)
B01L 3/567 (20130101) Original (OR) Class
B01L 3/5085 (20130101)
B01L 3/502738 (20130101)
B01L 2300/0681 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0867 (20130101)
B01L 2300/0874 (20130101)
B01L 2400/0487 (20130101)
B01L 2400/0622 (20130101)
B01L 2400/0644 (20130101)

Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating
F16K 11/0743 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 436/2575 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097910 ElDib et al.
FUNDED BY
Department of Defense (DOD)
Assistant Secretary of Defense for Special Operations/Low-Intensity Conflict (ASD SOLIC)
Combating Terrorism Technical Support Office (CTTSO)
APPLICANT(S) ASU RESEARCH ENTERPRISE (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Claudia ElDib (Scottsdale, Arizona);  Christian Michael Fortunato (Gilbert, Arizona)
ABSTRACT A collapsible container that includes a collapsible plate assembly formed by four plates joined by hinge pins along edges thereof, and includes a top lid and a bottom lid that may be joined to the collapsible plate assembly and latched into place. Each lid may be affixed to the collapsible plate assembly along one edge thereof with hinge pin segments configured to cooperate with hinge pin receiver segments, and along an opposing edge thereof with a clasp configured to engage a clasp receiver. A liner may be received within a plate assembly cavity formed by the collapsible plate assembly, with opposing end faces of the liner being configured to be depressed against the top and bottom lid to form a water-tight cavity. Methods for fabricating a collapsible container are also provided.
FILED Tuesday, September 29, 2020
APPL NO 17/036788
CURRENT CPC
Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages
B65D 21/086 (20130101) Original (OR) Class
B65D 43/167 (20130101)
B65D 51/242 (20130101)

Explosive Charges, e.g for Blasting, Fireworks, Ammunition
F42B 39/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097956 Blackmon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by The Secreatary of The Army (Alexandria, Virginia)
ASSIGNEE(S)
INVENTOR(S) Mickey D Blackmon (Vicksburg, Mississippi);  David M Rogillio (Vicksburg, Mississippi);  Christopher M Ables (Vicksburg, Mississippi);  Timothy P Hynum (Vicksburg, Mississippi);  Jeremy N Sellers (Vicksburg, Mississippi)
ABSTRACT In one embodiment, a roller jack includes: caster wheel attached to jack lift attached to an angle member having an angle member opening, and a locking mechanism to releasably lock the angle member to a corner block of a container through an elongated opening of the corner block. The locking mechanism includes: a locking mechanism baseplate having a baseplate protrusion, a swivel locking plate to be inserted through the angle member opening and the elongated opening of the corner block to the interior of the corner block, and a locking bolt for moving the swivel locking plate to an engaged position, where the swivel locking plate is prevented from passing through the angle member opening and the elongated opening of the corner block, and for threadingly moving the swivel locking plate toward the locking mechanism baseplate to press the angle member and the external wall of the corner block together.
FILED Friday, September 25, 2020
APPL NO 17/033314
CURRENT CPC
Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages
B65D 90/18 (20130101) Original (OR) Class

Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load
B66F 5/02 (20130101)
B66F 9/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098261 LEE et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Jungmin LEE (BOSTON, Massachusetts);  Jeffrey Charles WAY (Cambridge, Massachusetts)
ABSTRACT The technology described herein is directed to engineered polypeptides comprising an anti-GYPA antibody reagent and an EPO polypeptide. Further provided herein are methods of treating anemia by administering said polypeptides.
FILED Thursday, December 19, 2019
APPL NO 17/312523
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/06 (20180101)

Peptides
C07K 14/505 (20130101) Original (OR) Class
C07K 16/2896 (20130101)
C07K 2319/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098284 Bu et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USUHS)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
Department of Health and Human Services (HHS)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S) Wei Bu (Potomac, Maryland);  Masaru Kanekiyo (Chevy Chase, Maryland);  Michael Gordon Joyce (Washington, District of Columbia);  Jeffrey I. Cohen (Silver Spring, Maryland)
ABSTRACT Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus infection in mammals, and methods of using those compositions of matter for the same are disclosed. Also disclosed are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
FILED Thursday, December 16, 2021
APPL NO 17/553139
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/05 (20130101)
C07K 16/085 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098461 Majidi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) Carmel Majidi (Pittsburgh, Pennsylvania);  Michael Ford (Pittsburgh, Pennsylvania)
ABSTRACT A polymer composite having shape-morphing capabilities where the composite comprises a liquid crystal elastomer and liquid metal inclusions to improve thermal and/or electrical conductivity. The liquid metal inclusions are metals such as Gallium, alloys of Gallium, eutectic alloys, and other metals that have low melting points. The composite is soft and stretchable, while still retaining the shape-morphing characteristics of the liquid crystal elastomer. The composite is an electrical insulator, yet conductivity can be induced through mechanical pressure.
FILED Monday, September 27, 2021
APPL NO 17/486713
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/28 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 9/02 (20130101)
C08K 2201/001 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 5/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098573 ISMAGILOV et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Rustem ISMAGILOV (Altadena, California);  Erik JUE (Pasadena, California);  Daan WITTERS (San Diego, California)
ABSTRACT A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.
FILED Monday, September 13, 2021
APPL NO 17/473832
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/508 (20130101)
B01L 3/50851 (20130101)
B01L 3/502753 (20130101)
B01L 7/52 (20130101)
B01L 2200/0631 (20130101)
B01L 2200/0689 (20130101)
B01L 2300/04 (20130101)
B01L 2300/18 (20130101)
B01L 2300/069 (20130101)
B01L 2300/0672 (20130101)
B01L 2400/0605 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1003 (20130101) Original (OR) Class
C12N 15/1006 (20130101)
C12N 15/1013 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 21/6456 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098620 CHOUDHARY et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amit CHOUDHARY (Boston, Massachusetts);  Donghyun LIM (Cambridge, Massachusetts);  Praveen KOKKONDA (Boston, Massachusetts);  Sophia LAI (Boston, Massachusetts)
ABSTRACT The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.
FILED Friday, July 09, 2021
APPL NO 17/372406
CURRENT CPC
Heterocyclic Compounds
C07D 239/46 (20130101)
C07D 409/10 (20130101)
C07D 487/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/85 (20130101)
C12N 15/115 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098869 Esquilin-Mangual et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S)
INVENTOR(S) Omar Esquilin-Mangual (Vicksburg, Mississippi);  Catherine S. Stephens (Clinton, Mississippi);  Omar G. Flores (Vicksburg, Mississippi);  Andrew B. Edwards (Toney, Alabama);  Nicholas R. Boone (Vicksburg, Mississippi)
ABSTRACT In one embodiment, a frame and stair system for engaging a wall includes multiple pad assemblies, a distal frame assembly, a lower proximal frame assembly, an upper proximal frame assembly, multiple stair assemblies, and multiple upper panel stair adapter brackets. A lower stair assembly is coupled with a left stair pad assembly, a right stair pad assembly, a left distal leveling pad, and a right distal leveling pad. A middle stair assembly is coupled with the distal frame assembly and the upper proximal frame assembly. An upper stair assembly is coupled with the upper proximal frame assembly. The upper proximal frame assembly is coupled with the lower proximal frame assembly. A left upper panel stair adapter bracket and a right upper panel stair adapter bracket are coupled with the upper stair assembly and are configured to engage an upper edge of the wall.
FILED Monday, September 28, 2020
APPL NO 17/035332
CURRENT CPC
Finishing Work on Buildings, e.g Stairs, Floors
E04F 11/18 (20130101)
E04F 11/022 (20130101) Original (OR) Class

Scaffolding; Forms; Shuttering; Building Implements or Aids, or Their Use; Handling Building Materials on the Site; Repairing, Breaking-up or Other Work on Existing Buildings
E04G 13/062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099412 Esquilin-Mangual et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S)
INVENTOR(S) Omar Esquilin-Mangual (Vicksburg, Mississippi);  Catherine S. Stephens (Clinton, Mississippi);  Omar G. Flores (Vicksburg, Mississippi);  Andrew B. Edwards (Toney, Alabama);  Erik M. Chappell (Vicksburg, Mississippi)
ABSTRACT Ready armor modular protective systems that can be rapidly deployed in an urban environment. Exemplary armor systems include a container, and a wall assembly that fits inside of the container when in a collapsed configuration. The wall assembly includes a first end section, a second end section, a constraint mechanism, and first and second locking mechanisms. The first end section has a first space frame unit, and the second end section has second and third space frame units. A locking mechanism prevent relative vertical displacement from occurring between adjacent second and third space frame units. The constraint mechanism keeps the first and third space frame units at a fixed distance from one another. The constraint mechanism, when coupled with the first and third space frame units, keeps the locking mechanism from being removed from the second end section.
FILED Tuesday, September 29, 2020
APPL NO 17/037480
CURRENT CPC
General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings
E04B 1/3445 (20130101)

Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 5/013 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099491 Lucente et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of the Navy (DON)
United States Marine Corps (USMC)
Marine Corps Systems Command (MARCORSYSCOM)
APPLICANT(S) Nanohmics, Inc. (Austin, Texas)
ASSIGNEE(S) Nanohmics, Inc. (Austin, Texas)
INVENTOR(S) Mark E. Lucente (Austin, Texas);  Chris W. Mann (Austin, Texas)
ABSTRACT Methods use a tunable notch filter for constructing a spectral map of electromagnetic radiation in a selected spectral band that is incident on a notch filter for a plurality of time periods. Electromagnetic radiation is passed by an electronically tuned notch filter to a detector array for the plurality of selected time periods, and the detector response is determined. For at least a first selected time period the notch filter is tuned to selectively attenuate the passing of one or more selected sub-bands of electromagnetic radiation in the selected spectral band. Information about the selectively attenuated radiation is determined and used along with information about the radiation passed to the detector array for each time period to construct a spectral map. Electronically tunable notch filters may be made with metamaterials such as patterned graphene.
FILED Wednesday, March 24, 2021
APPL NO 17/210913
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/0227 (20130101)
G01J 3/2823 (20130101) Original (OR) Class
G01J 2003/1247 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099558 Lever et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by the Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S)
INVENTOR(S) James H. Lever (Lebanon, New Hampshire);  Susan Taylor (Lebanon, New Hampshire);  Garrett R. Hoch (Lebanon, New Hampshire);  Emily Asenath-Smith (Norwich, Vermont)
ABSTRACT In one embodiment, a tribometer comprises: an infrared (IR) transparent and optically transparent disk coupled to a platform, the disk having an observation side disk surface on an observation side of the disk and a contact side disk surface on a contact side of the disk; a motor coupled to the disk to rotate the disk around a rotational axis of the disk; a pivot support coupled to the platform; a pivoting member connected to the pivot support to pivot along a pivot plane; a sample holder configured to hold a sample and be coupled with the pivoting member to place the sample in contact with the contact side disk surface of the disk; and an IR camera and an optical microscope disposed on the observation side of the disk to observe the sample in sliding contact with the contact side disk surface of the disk driven in rotation.
FILED Wednesday, September 30, 2020
APPL NO 17/037703
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 19/02 (20130101) Original (OR) Class
G01N 19/08 (20130101)
G01N 21/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099678 Walt et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) David R. Walt (Boston, Massachusetts);  David M. Rissin (Lexington, Massachusetts)
ABSTRACT Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.
FILED Friday, October 08, 2021
APPL NO 17/496926
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6837 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/543 (20130101)
G01N 33/581 (20130101) Original (OR) Class
G01N 33/54346 (20130101)
G01N 33/54366 (20130101)
G01N 33/54386 (20130101)
G01N 2333/938 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099699 Waite et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) James W. Waite (Eastsound, Washington);  David Raymond Dall'Osto (Seattle, Washington);  Peter Hans Dahl (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) James W. Waite (Eastsound, Washington);  David Raymond Dall'Osto (Seattle, Washington);  Peter Hans Dahl (Seattle, Washington)
ABSTRACT An airborne acoustic vector sensor for simultaneously measuring triaxial particle acceleration in three dimensions and pressure includes a triaxial MEMS accelerometer sensitive to an Earth gravitational field. The airborne acoustic vector sensor includes one or multiple MEMS microphones sensitive to sound pressure and overlapping the accelerometer in frequency. The airborne acoustic vector sensor includes a solid body having a density approximating a density of air. The accelerometer is mounted in or upon the solid body. The airborne acoustic vector sensor includes a suspension system supporting the accelerometer and solid body within a framework.
FILED Thursday, May 27, 2021
APPL NO 17/332390
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 2201/0235 (20130101)
B81B 2201/0257 (20130101)

Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement
G01P 15/18 (20130101) Original (OR) Class

Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for
G10K 11/004 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 29/005 (20130101)
H04R 2201/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099711 Grayson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Matthew Grayson (Evanston, Illinois);  Chulin Wang (Evanston, Illinois);  Juncen Li (Evanston, Illinois);  William H. Reinhardt (Iowa City, Iowa)
ABSTRACT Systems and methods include an electrical switch that establishes a first electrical conducting path between terminals of an electrical measurement apparatus through one or more electrical leads and an electrically-conductive sample in a first state, and a second electrical conducting path between the terminals through the one or more electrical leads while bypassing the sample in a second state. A voltage VS+L is measured across all of the sample and the one or more electrical leads in the first state, while a voltage VL is measured across the one or more electrical leads while bypassing the sample in the second state. Calculations according to the equation VS=VS+L−VL are performed to determine a precision DC voltage measurement of a voltage across the sample VS in the absence of Seebeck voltage offsets contributed by the one or more electrical leads.
FILED Friday, September 24, 2021
APPL NO 17/484939
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 19/0084 (20130101) Original (OR) Class
G01R 33/072 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 35/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099830 MITCHELL et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Jason E. MITCHELL (Nashville, Tennessee);  Brett C. BYRAM (Nashville, Tennessee);  Joseph HOWARD (Nashville, Tennessee);  Christopher KHAN (Nashville, Tennessee);  Don TRUEX (Nashville, Tennessee)
ABSTRACT Visibility of a surface in turbid water can be provided using a sonar array, a plurality of acoustic mirrors, and a computing device. The sonar array can be configured to form an ultrasonic beam with a lateral dimension of a point spread function and an elevational dimension of the point spread function. The plurality of acoustic mirrors can be configured to shape and steer the point spread function. The computing device can include a non-transitory memory storing instructions and a processor configured to access the non-transitory memory and execute the instructions to sweep the ultrasound beam in the lateral dimension and the elevational dimension by moving at least one of the plurality of acoustic mirrors. Sweeping the ultrasound beam allows the processor to acquire a three dimensional data set that is used to create a projection-style reconstruction of a location in the water.
FILED Friday, April 23, 2021
APPL NO 17/239436
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 15/8915 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099848 Hunt et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) Corvid Technologies LLC (Mooresville, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Sean Matthew Hunt (Cary, North Carolina);  Stephen Michael Daigle (Davidson, North Carolina);  Kristopher Reidar Vorren (Mooresville, North Carolina)
ABSTRACT Described herein are scintillation detectors such as alpha- and beta-particle scintillation detectors along with methods of preparing and using such detectors. The scintillation detector comprises a protective layer including light-blocking nanoparticles.
FILED Thursday, September 23, 2021
APPL NO 17/482736
CURRENT CPC
Measurement of Nuclear or X-radiation
G01T 1/20188 (20200501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099893 Paudel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
The Aerospace Corporation (AEROSPACE)
Federally Funded Research and Development Center (FFRDC)
Operated by The Aerospace Corporation (AEROSPACE) at El Segundo, CA
APPLICANT(S) The Aerospace Corporation (El Segundo, California)
ASSIGNEE(S) The Aerospace Corporation (El Segundo, California)
INVENTOR(S) Uttam Paudel (La Palma, California);  George C. Valley (Los Angeles, California);  Marta Luengo-Kovac (La Palma, California);  Thomas Justin Shaw (Reston, Virginia);  Matthew N. Ashner (Redondo Beach, California)
ABSTRACT A method for performing an operation on an input signal includes receiving, by a multi-mode waveguide, the input signal imposed on laser light. The received input signal imposed on the laser light is propagated through the waveguide a plurality of times in a plurality of modes, the modes interfering each time they propagate through the waveguide to generate an interference pattern of the plurality of modes. Portions of the interference pattern of the plurality of modes are nonlinearly activated each time those modes propagate through the multi-mode waveguide. Portions of the activated interference pattern of the plurality of modes are output to an optical detector array in parallel with one another each time those modes propagate through the multi-mode waveguide.
FILED Tuesday, September 29, 2020
APPL NO 17/037486
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/12 (20130101)
G02B 6/14 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 17/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100009 Frantz et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Jesse Frantz (Washington, District of Columbia);  Jason Myers (Alexandria, Virginia);  Vinh Q. Nguyen (Fairfax, Virginia);  Jasbinder Sanghera (Ashburn, Virginia);  Robel Bekele (Washington, District of Columbia);  Anthony Romano Clabeau (Alexandria, Virginia)
ABSTRACT Tunable devices and methods for fine tuning the optical responses of thin film devices post fabrication are described. This approach modifies the refractive indices of the chalcogenide glass thin films incorporated into the devices, and using this change in the refractive indices to fine tune the optical responses of the devices. Thermal annealing may be used to modify the refractive index. Thermal annealing provides good uniformity in large-area devices and may be applied to multi-layer structures.
FILED Wednesday, September 29, 2021
APPL NO 17/449349
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/0147 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/324 (20130101)
H01L 21/02568 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100508 Pawlowski et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Intel Corporation (Santa Clara, California)
ASSIGNEE(S) Intel Corporation (Santa Clara, California)
INVENTOR(S) Robert Pawlowski (Beaverton, Oregon);  Ankit More (San Mateo, California);  Vincent Cave (Hillsboro, Oregon);  Sriram Aananthakrishnan (Portland, Oregon);  Jason M. Howard (Portland, Oregon);  Joshua B. Fryman (Corvallis, Oregon)
ABSTRACT Embodiments of apparatuses and methods for copying and operating on matrix elements are described. In embodiments, an apparatus includes a hardware instruction decoder to decode a single instruction and execution circuitry, coupled to hardware instruction decoder, to perform one or more operations corresponding to the single instruction. The single instruction has a first operand to reference a base address of a first representation of a source matrix and a second operand to reference a base address of second representation of a destination matrix. The one or more operations include copying elements of the source matrix to corresponding locations in the destination matrix and filling empty elements of the destination matrix with a single value.
FILED Friday, December 25, 2020
APPL NO 17/134251
CURRENT CPC
Electric Digital Data Processing
G06F 9/3001 (20130101)
G06F 9/3818 (20130101)
G06F 9/30032 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100919 Chakrabarti et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Defense Contract Management Agency (DCMA)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Schenectady, New York)
INVENTOR(S) Suryarghya Chakrabarti (Evendale, Ohio);  Kevin Turner (Evendale, Ohio);  Yoon Seok Choi (Evendale, Ohio);  Douglas L. Washburn (Evendale, Ohio);  Liping Wang (Niskayuna, New York);  Andrew J. Blair (Evendale, Ohio)
ABSTRACT A method of analyzing a blended airfoil that includes generating a plurality of simulated blended airfoil designs each including one of a plurality of blend geometries, training surrogate models representing the plurality of simulated blended airfoil designs based on natural frequency, modal force, and Goodman scale factors, determining a likelihood of operational failure of each of the plurality of blended airfoil designs in response to one or more vibratory modes, determining which of the plurality of simulated blended airfoil designs violate at least one aeromechanical constraint and generating, a blend design space visualization including a blend design space, where the blend design space includes one or more restricted regions indicating blended airfoil designs where at least one aeromechanical constraint is violates and one or more permitted regions indicating blended airfoil designs where no aeromechanical constraints are violated.
FILED Friday, April 16, 2021
APPL NO 17/232540
CURRENT CPC
Electric Digital Data Processing
G06F 30/17 (20200101) Original (OR) Class
G06F 30/27 (20200101)
G06F 2111/08 (20200101)

Computer Systems Based on Specific Computational Models
G06N 7/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101046 Lin et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Robert Bosch GmbH (Stuttgart, Germany)
ASSIGNEE(S)
INVENTOR(S) Wan-Yi Lin (Wexford, Pennsylvania);  Mohammad Sadegh Norouzzadeh (Pittsburgh, Pennsylvania);  Jeremy Zieg Kolter (Pittsburgh, Pennsylvania);  Jinghao Shi (Pittsburgh, Pennsylvania)
ABSTRACT A system and method relate to providing machine learning predictions with defenses against patch attacks. The system and method include obtaining a digital image and generating a set of location data via a random process. The set of location data include randomly selected locations on the digital image that provide feasible bases for creating regions for cropping. A set of random crops is generated based on the set of location data. Each crop includes a different region of the digital image as defined in relation to its corresponding location data. The machine learning system is configured to provide a prediction for each crop of the set of random crops and output a set of predictions. The set of predictions is evaluated collectively to determine a majority prediction from among the set of predictions. An output label is generated for the digital image based on the majority prediction. The output label includes the majority prediction as an identifier for the digital image.
FILED Monday, September 28, 2020
APPL NO 17/034479
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/628 (20130101)
G06K 9/6256 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
G06N 3/084 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/20132 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101175 Lee et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Wei-Han Lee (White Plains, New York);  Changchang Liu (White Plains, New York);  Shiqiang Wang (White Plains, New York);  Bong Jun Ko (Harrington Park, New Jersey);  Yuang Jiang (New Haven, Connecticut)
ABSTRACT A computer-implemented method, a computer program product, and a computer system for incremental and decentralized pruning of a machine learning model in federated learning. A federated learning system determines a serial sequence of participating in model pruning by agents in the federated learning system. A server in the federated learning system sends, to a first agent in the serial sequence, an initial model to trigger a federated pruning process for the machine learning model. The each of agents in the serial sequence prunes the machine learning model. The each of agents in the serial sequence generates an intermediately pruned model for an immediately next agent to prune. A final agent in the serial sequence prunes the machine learning model and generates a finally pruned model. The final agent sends the finally pruned model to the server.
FILED Friday, September 25, 2020
APPL NO 17/031930
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/082 (20130101)
G06N 20/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101215 McAllister
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Life Cycle Management Center (AFLCMC)
APPLICANT(S) Branford John McAllister (Niceville, Florida)
ASSIGNEE(S)
INVENTOR(S) Branford John McAllister (Niceville, Florida)
ABSTRACT Program managers are responsible for assessing computer-based models used in their programs. No mechanism exists to evaluate models so current or potential users can assess their utility. The Model Maturity Level (MML) assessment process and tool is an objective method to assess the state of development of any model at a point in time. The process assigns an overall MML from 1 to 9—the lowest score among objective criteria based on attributes that users require in models. The assessment relies upon objective evidence (artifacts) showing that model attributes have been developed and proven through rigorous, industry-standard processes. The assessment includes a description of the model, the assessment rubric, and a summary of results. The MML concept and tool are based on previous work at NASA and DOE, plus other work in the scholarly literature. MMLs are analogous to the DoD's technology readiness levels (TRLs) for ease of translation.
FILED Wednesday, September 02, 2020
APPL NO 16/948093
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/067 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101490 Bruder et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S)
INVENTOR(S) Gerd Bruder (Orlando, Florida);  Gregory Welch (Orlando, Florida);  Kangsoo Kim (Orlando, Florida);  Zubin Choudhary (Orlando, Florida)
ABSTRACT One or more cameras capture objects at a higher resolution than the human eye can perceive. Objects are segmented from the background of the image and scaled to human perceptible size. The scaled-up objects are superimposed over the unscaled background. This is presented to a user via an augmented reality display whereby the process selectively amplifies the size of the objects' spatially registered retinal projection while maintaining a natural (unmodified) view in the remainder of the visual field.
FILED Wednesday, May 26, 2021
APPL NO 17/330679
CURRENT CPC
Image Data Processing or Generation, in General
G06T 3/40 (20130101) Original (OR) Class
G06T 7/194 (20170101)

Image or Video Recognition or Understanding
G06V 10/764 (20220101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101627 Pappas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) George J. Pappas (Philadelphia, Pennsylvania);  Hamed Hassani (Philadelphia, Pennsylvania);  Alexander Robey (Philadelphia, Pennsylvania)
ABSTRACT Methods, systems, and computer readable media for model-based robust deep learning. In some examples, a method includes obtaining a model of natural variation for a machine learning task. The model of natural variation includes a mapping that specifies how an input datum can be naturally varied by a nuisance parameter. The method includes training, using the model of natural variation and training data for the machine learning task, a neural network to complete the machine learning task such that the neural network is robust to natural variation specified by the model of natural variation.
FILED Thursday, June 03, 2021
APPL NO 17/337972
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)

Image or Video Recognition or Understanding
G06V 10/72 (20220101)
G06V 10/7747 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101742 Del Sesto et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
APPLICANT(S) UI LABS (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Antonio Del Sesto (Chicago, Illinois);  Rodrigo Santos Quintella Freire (Chicago, Illinois);  Alejandro Velez (Park Ridge, Illinois)
ABSTRACT An industrial operations network is disclosed herein. More particularly the disclosure may pertain to an industrial operations network designed for facilitating the training of security concepts for industrial operations. In one embodiment, an apparatus for training industrial security concepts is disclosed. The apparatus may comprise a portable industrial operations network comprising: at least one router; at least one firewall; at least one programmable logic controller; and at least one display connected to the portable industrial operations network, said at least one display adapted to display, at different times, normal operating conditions of said portable industrial operations network and security fault conditions in said portable industrial operations network.
FILED Wednesday, September 30, 2020
APPL NO 17/039540
CURRENT CPC
Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 5/06 (20130101) Original (OR) Class
G09B 9/00 (20130101)
G09B 19/0053 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101754 Sharp et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S)
INVENTOR(S) Jeremy A. Sharp (Vicksburg, Mississippi);  Zachary S. Smith (Vicksburg, Mississippi);  Duncan Bryant (Vicksburg, Mississippi)
ABSTRACT In one embodiment, a bathymetry system includes a base slab, multiple spacer assemblies, a decking layer, multiple computer numerical control routed blocks, a waterproof coating, and multiple floor joints. The spacer assemblies are coupled with a top surface of the base slab, the decking layer is disposed on top surfaces of the spacer assemblies, the blocks are disposed on a top surface of the decking layer, floor joints are disposed between blocks and the decking layer, and the waterproof coating is disposed on top surfaces of the blocks. The top surfaces of the routed blocks are shaped so that the blocks collectively provide a bathymetry profile, such as a bottom contour of a riverbed.
FILED Wednesday, September 30, 2020
APPL NO 17/039777
CURRENT CPC
Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 23/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102293 POON et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) XILINX, INC. (San Jose, California)
ASSIGNEE(S)
INVENTOR(S) Chi Fung POON (Sunnyvale, California);  Asma LARABA (San Jose, California);  Parag UPADHYAYA (Los Gatos, California)
ABSTRACT Examples described herein generally relate to communication between integrated circuit (IC) dies in a wafer-level fan-out package. In an example, an electronic device includes a wafer-level fan-out package. The wafer-level fan-out package includes a first integrated circuit (IC) die, a second IC die, and a redistribution structure. The first IC die includes a transmitter circuit. The second IC die includes a receiver circuit. The redistribution structure includes physical channels electrically connected to and between the transmitter circuit and the receiver circuit. The transmitter circuit is configured to transmit multiple single-ended data signals and a differential clock signal through the physical channels to the receiver circuit. The receiver circuit is configured to capture data from the multiple single-ended data signals using a first single-ended clock signal based on the differential clock signal.
FILED Tuesday, September 29, 2020
APPL NO 17/037363
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/66 (20130101) Original (OR) Class
H01L 23/5386 (20130101)
H01L 25/16 (20130101)
H01L 2224/02379 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102608 Venkatasubramanian et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USUHS)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Rama Venkatasubramanian (Cary, North Carolina);  Luke E. Osborn (Baltimore, Maryland);  Robert S. Armiger (Catonsville, Maryland);  Meiyong Himmtann (Laurel, Maryland);  Jonathan M. Pierce (North Eldersburg, Maryland)
ABSTRACT A fast-rate thermoelectric device control system includes a fast-rate thermoelectric device, a sensor, and a controller. The fast-rate thermoelectric device includes a thermoelectric actuator array disposed on a wafer, and the thermoelectric actuator array includes a thin-film thermoelectric (TFTE) actuator that generates a heating and/or a cooling effect in response to an electrical current. The sensor is configured to measure a temperature associated with the heating or cooling effect and output a feedback signal indicative of the measured temperature. The controller is in communication with the fast-rate thermoelectric device and the sensor, and is configured to control the electrical current based on the feedback signal.
FILED Tuesday, December 07, 2021
APPL NO 17/544391
CURRENT CPC
Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 21/02 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/16 (20130101)
H01L 35/16 (20130101)
H01L 35/30 (20130101) Original (OR) Class
H01L 35/325 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102751 Gerasopoulos et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Konstantinos Gerasopoulos (Odenton, Maryland);  Bing Tan (Ann Arbor, Michigan);  Priestly T. Shuler (Baltimore, Maryland);  Matthew W. Logan (Columbia, Maryland);  Sarah K. Adams (Olney, Maryland);  Matthew A. Hagedon (Columbia, Maryland)
ABSTRACT A method of manufacturing a three-dimensional electrochemical lithium battery includes forming a first electrode on an underlying layer comprising aerosolizing a first ink formulation comprising a slurry including nanoparticles or microparticles of a first active material and a binder, and depositing the slurry onto the underlying layer to form a first electrode layer. A permeable separator layer is formed on the first electrode by aerosolizing a polymer precursor solution, exposing the aerosolized polymer precursor solution to a first activating radiation source to form partially cured polymer spheres in the aerosolized stream, focusing and directing the aerosolized stream onto a substrate to form the permeable separator layer of the partially cured polymer spheres, and exposing the partially cured polymer spheres on the substrate to a second activating radiation source to fully cure the partially cured polymer spheres. A second electrode is formed on the permeable separator layer by aerosolizing a second ink formulation comprising a slurry including nanoparticles or microparticles of a second active material and a binder, and depositing the slurry onto the permeable separator layer.
FILED Tuesday, July 20, 2021
APPL NO 17/380527
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/112 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 80/00 (20141201)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/661 (20130101)
H01M 10/058 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102942 Yu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
ASSIGNEE(S)
INVENTOR(S) Shui-Qing Yu (Fayetteville, Arkansas);  Yiyin Zhou (Fayetteville, Arkansas);  Wei Du (Dallas, Pennsylvania)
ABSTRACT A laser diode including a double heterostructure comprising a top layer, a buffer layer formed on a substrate, and an intrinsic active layer formed between the top layer and the buffer layer. The top layer and the buffer layer have opposite types of conductivity. The active layer has a bandgap smaller than that of the buffer layer or the top layer. The double heterostructure includes Ge, SiGe, GeSn, and/or SiGeSn materials.
FILED Tuesday, September 28, 2021
APPL NO 17/487140
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 5/3054 (20130101)
H01S 5/3077 (20130101)
H01S 5/3407 (20130101)
H01S 5/3426 (20130101) Original (OR) Class
H01S 5/04256 (20190801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220103172 Mundhada et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
APPLICANT(S) Yale University (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Shantanu Mundhada (New Haven, Connecticut);  Nicholas Frattini (New Haven, Connecticut);  Shruti Puri (New Flaven, Connecticut);  Shyam Shankar (New Haven, Connecticut);  Steven M. Girvin (Hamden, Connecticut);  Michel Devoret (New Haven, Connecticut)
ABSTRACT Parametrically pumped four-wave mixing is a key building block for many developments in the field of superconducting quantum information processing. However, undesired frequency shifts such as Kerr, cross-Ken and Stark shifts inherent with four-wave mixing, lead to difficulties in tuning up the desired parametric processes and, for certain applications, severely limit the fidelities of the resulting operations. Some embodiments include a Josephson four-wave mixing device consisting of a SQUID transmon coupled to a half-flux biased SNAIL transmon, a.k.a. capacitively shunted flux qubit. When the two transmon have matching frequencies, an interference effect cancels the negative Kerr of the SQUID transmon with the positive Kerr of the SNAIL transmon while preserving parametric four-wave mixing capabilities.
FILED Wednesday, January 15, 2020
APPL NO 17/423631
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/18 (20130101)
H01L 39/025 (20130101)

Pulse Technique
H03K 17/92 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220103572 Strayer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Raytheon BBN Technologies Corp. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) William Timothy Strayer (West Newton, Massachusetts);  Brandon Doherty Kalashian (Waltham, Massachusetts);  Michael Hassan Atighetchi (Framingham, Massachusetts);  Stephane Yannick Blais (Framingham, Massachusetts);  Samuel Cunningham Nelson (Sudbury, Massachusetts)
ABSTRACT Techniques for enforcing trust policies for payload data transmitted through a data provisioning layer include: receiving, by a node in the data provisioning layer, payload data to be delivered to a recipient; obtaining, by the node, a trust policy indicating multiple attributes used to determine trustworthiness of payloads; determining, by the node, a set of values of the attributes associated with the payload data; generating, by the node, a trustworthiness opinion based at least on the trust policy and the set of values of the attributes; transmitting, by the node, the payload data and the trustworthiness opinion via the data provisioning layer toward the recipient; computing, by the recipient, a trustworthiness metric associated with the payload data based at least on the trustworthiness opinion; and determining, by the recipient, an action to take with respect to the payload data based at least on the trustworthiness metric.
FILED Friday, December 10, 2021
APPL NO 17/548068
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/123 (20130101)
H04L 63/126 (20130101) Original (OR) Class
H04L 63/1408 (20130101)
H04L 67/2804 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220104204 Kong et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Justin S. Kong (Clarksville, Maryland);  Fikadu T. Dagefu (Silver Spring, Maryland);  Brian M. Sadler (Laurel, Maryland)
ABSTRACT A system and method for distributed wireless communications comprising a first group of agents selected and configured to wirelessly transmit a communication signal to a client, wherein the first group of agents is capable of forming a radiation beam carrying the communication signal vectored substantially toward the client, and a second group of agents selected and configured to wirelessly broadcast communication signal interference, wherein the second group of agents is capable of forming a radiation beam not vectored substantially toward the client. Consequently, the first group of agents securely communicates with the client and the second group of agents suppresses the ability of an unauthorized, eavesdropping receiver from intercepting the communications signal.
FILED Thursday, March 18, 2021
APPL NO 17/205355
CURRENT CPC
Wireless Communication Networks
H04W 16/28 (20130101)
H04W 72/08 (20130101) Original (OR) Class
H04W 72/046 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20220096402 Koppisch et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Office of Advanced Cyberinfrastructure (OAC)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Phoenix, Arizona);  DIXIE STATE UNIVERSITY (St. George, Utah);  TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico);  COLLEGE OF NEW JERSEY (Ewing, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Andrew T. Koppisch (Flagstaff, Arizona);  Gerrick E. Lindberg (Flagstaff, Arizona);  David T. Fox (Los Alamos, New Mexico);  Joseph Baker (Ewing, New Jersey);  Alexanndra J. Heyert (Flagstaff, Arizona);  Rico Del Sesto (St. George, Utah);  Joshua R. Greene (Flagstaff, Arizona)
ABSTRACT Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.
FILED Wednesday, December 01, 2021
APPL NO 17/457176
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 27/00 (20130101)
A01N 37/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/01 (20130101)
A61K 31/11 (20130101)
A61K 31/14 (20130101) Original (OR) Class
A61K 31/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096975 Zhang et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Yuepeng Zhang (Naperville, Illinois);  Devon J. Powers (Lemont, Illinois);  Krzysztof Pupek (Plainfield, Illinois);  John R. Hryn (Hawthorn Woods, Illinois);  Gregory K. Krumdick (Homer Glen, Illinois);  Santanu Chaudhuri (Countryside, Illinois)
ABSTRACT Reusable filters for personal protective equipment (PPE) may prevent shortages of PPE and save fabrication time, resources, and money. Disclosed is a method and system for fabrication of nanofiber filter media for PPE. The method includes positioning a substrate to receive nanofibers thereon, providing a voltage gradient in a region of the substrate, and electrospinning nanofibers onto the substrate. The methods and associated systems allow autoclaving of the filter medium at temperatures of up to 300 degrees for sanitizing the filter medium. Additionally, the methods and associated system allow for the inclusion of an anti-pathogen agent in the nanofiber filter media.
FILED Wednesday, September 30, 2020
APPL NO 17/039188
CURRENT CPC
Devices, Apparatus or Methods for Life-saving
A62B 17/00 (20130101)
A62B 23/02 (20130101)

Separation
B01D 39/083 (20130101) Original (OR) Class
B01D 46/0028 (20130101)
B01D 2239/10 (20130101)
B01D 2239/025 (20130101)
B01D 2239/065 (20130101)
B01D 2239/0442 (20130101)
B01D 2239/0631 (20130101)
B01D 2239/1233 (20130101)
B01D 2279/65 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097016 Aytug et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Tolga Aytug (Knoxville, Tennessee);  Kai Li (Farragut, Tennessee);  Meghan E. Lamm (Oak Ridge, Tennessee);  Diana Hun (Lenoir City, Tennessee);  Kaushik Biswas (Davis, California)
ABSTRACT A fluid storage media includes a plurality of microspheres. Each microsphere includes a porous core with a porous core material and having an exterior surface. A stored fluid is within the porous core. A coating layer covers all of the exterior surface of the porous core. The coating layer includes a coating material which transitions from a first state to a second state, wherein in the first state the coating material is permeable to the stored fluid, and in the second state the material is impermeable to the stored fluid. The coating material in the second state is configured to encapsulate and maintain the stored fluid inside the porous core. A method of making a fluid storage media, a method of delivering a fluid and a method of delivering a biologically active fluid medication to a patient are also disclosed.
FILED Monday, October 25, 2021
APPL NO 17/509869
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0004 (20130101)
A61K 9/5073 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 13/22 (20130101)
B01J 13/203 (20130101) Original (OR) Class

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 27/10 (20130101)
B32B 27/20 (20130101)
B32B 2264/303 (20200801)
B32B 2307/304 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 20/0032 (20130101)
C04B 20/1029 (20130101)
C04B 2111/00612 (20130101)
C04B 2201/30 (20130101)

Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for
D21H 17/74 (20130101)

General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings
E04B 1/806 (20130101)

Structural Elements; Building Materials
E04C 2/288 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097020 Matteo et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Edward N. Matteo (Albuquerque, New Mexico);  Clay Payne (Albuquerque, New Mexico);  Amanda Sanchez (Albuquerque, New Mexico);  Nelson S. Bell (Albuquerque, New Mexico);  Yifeng Wang (Albuquerque, New Mexico);  Jessica N. Kruichak (Albuquerque, New Mexico);  Melissa Marie Mills (Albuquerque, New Mexico)
ABSTRACT An anionic sorption agent, method for forming the anionic sorption agent and a barrier system are disclosed. The anionic sorption agent including a modified pseudo or glycol-boehmite base comprising a structure having cationic metal ion sites. The method for forming the anionic sorption agent includes providing a pseudo or glycol-boehmite base and contacting the pseudo or glycol-boehmite base a modifying composition comprising a metallic ion to form the modified pseudo or glycol-boehmite base comprising a structure having cationic metal ion sites. The barrier system includes the anionic sorption agent comprising a first barrier component comprising a modified pseudo or glycol-boehmite base comprising a structure having cationic metal ion sites and a second barrier component comprising a cationic sorption agent.
FILED Thursday, December 09, 2021
APPL NO 17/546190
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/08 (20130101)
B01J 20/223 (20130101) Original (OR) Class
B01J 20/28061 (20130101)
B01J 20/28064 (20130101)
B01J 20/28066 (20130101)
B01J 41/09 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097027 Chong
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Lina Chong (Westmont, Illinois)
ABSTRACT Methods for producing a carbon-free, PGM-free support for PGM catalyst. The catalytic material comprises PGM metals disposed on a carbon-free support which is catalytic but free of PGM.
FILED Wednesday, September 30, 2020
APPL NO 17/039747
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/185 (20130101)
B01J 23/75 (20130101)
B01J 23/462 (20130101)
B01J 23/468 (20130101) Original (OR) Class
B01J 23/8871 (20130101)
B01J 31/1691 (20130101)
B01J 35/06 (20130101)
B01J 35/0033 (20130101)
B01J 37/08 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097255 Lind et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Randall F. Lind (Loudon, Tennessee);  Brian K. Post (Knoxville, Tennessee);  Phillip Chesser (Knoxville, Tennessee);  Celeste Atkins (Clinton, Tennessee)
ABSTRACT A print head for additive manufacturing with a material includes an accumulator comprising an elongated body with an open interior and an inside diameter. A slide tube is slidably mounted within the open interior of the elongated body. The slide tube has a sealing piston head hermetically sealing the open end within the elongated body to define a variable gas containment space. A pressurized gas is supplied to the gas containment space. A rotatable shaping nozzle with an opening for discharging material is provided. A positive displacement extruder delivers material from the accumulator to the nozzle assembly. The nozzle assembly can include a nozzle rotation drive for rotating the shaping nozzle about an axis of rotation. The nozzle opening can be aligned with the axis of rotation, and defines a discharge axis that can be perpendicular to the axis of rotation. A method of additive manufacturing is also disclosed.
FILED Wednesday, September 30, 2020
APPL NO 17/039292
CURRENT CPC
Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 1/001 (20130101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/209 (20170801)
B29C 64/241 (20170801)
B29C 64/321 (20170801)
B29C 64/393 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 50/02 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097327 Jiang et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Zhang Jiang (Naperville, Illinois);  Miaoqi Chu (Willowbrook, Illinois);  Jin Wang (Hinsdale, Illinois);  Michael J. Pellin (Naperville, Illinois);  Prabhjot Mehta Menon (Palatine, Illinois)
ABSTRACT A method of fabricating a refractive optical element on a substrate may provide less expensive and more compact optics for an X-ray system. The method includes coating the substrate with a resin and providing radiation to a portion of the resin to cause two photon polymerization of the resin. The method further includes forming, by two photon polymerization, a first surface of a polymer refractive optical element from the resin. The first surface is disposed along an optical axis of the refractive optical element and the first surface has a roughness of less than 100 nanometers. Further, the method includes forming, by two photon polymerization, a second surface of the polymer refractive optical element. The second surface is disposed along the optical axis of the refractive optical element and the second surface has a roughness of less than 100 nanometers.
FILED Wednesday, September 30, 2020
APPL NO 17/039624
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00365 (20130101) Original (OR) Class
B29D 11/00403 (20130101)

Optical Elements, Systems, or Apparatus
G02B 3/0012 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/001 (20130101)

Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes
G21K 1/065 (20130101)
G21K 2201/067 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097721 AGGOUNE et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) DELPHI TECHNOLOGIES IP LIMITED (St. Michael, Barbados)
ASSIGNEE(S)
INVENTOR(S) Karim AGGOUNE (Auburn Hills, Michigan);  Frans M. THEUNISSEN (Rochester Hills, Michigan)
ABSTRACT A method for assignment of vehicle control includes receiving route data indicating a route between a starting location of a vehicle and a destination location, and determining an optimal vehicle configuration for the route based on a target vehicle speed and a hybrid torque split. The method further includes receiving a driver requested torque value and determining a passive pedal torque value based on the route data and vehicle powertrain data. The method further includes selectively assigning control of the vehicle to a vehicle system or to a driver of the vehicle based on the driver requested torque value and the passive pedal torque value.
FILED Tuesday, September 29, 2020
APPL NO 17/035904
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 10/04 (20130101)
B60W 10/10 (20130101)
B60W 50/10 (20130101)
B60W 50/087 (20130101) Original (OR) Class
B60W 2510/0604 (20130101)
B60W 2520/30 (20130101)
B60W 2556/50 (20200201)
B60W 2710/105 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098244 Kong et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Leopold Kong (Bethesda, Maryland);  Ian A. Wilson (La Jolla, California);  Natalia De Val (San Diego, California);  Andrew B. Ward (San Diego, California);  Dennis Burton (La Jolla, California);  Linling He (San Diego, California);  Jiang Zhu (San Diego, California)
ABSTRACT The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
FILED Thursday, December 16, 2021
APPL NO 17/553070
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/21 (20130101)
A61K 47/6929 (20170801)

Peptides
C07K 14/005 (20130101)
C07K 14/162 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2740/16122 (20130101)
C12N 2740/16134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098622 Cruz-Morales et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Pablo Cruz-Morales (Berkeley, California);  Kevin Yin (Berkeley, California);  Robert Bertrand (Oakland, California);  Ethan Oksen (Berkeley, California);  Aidan Cowan (Berkeley, California);  Yuzhong Liu (Berkeley, California);  Eric Sundstrom (San Mateo, California);  Jay D. Keasling (Berkeley, California)
ABSTRACT The present invention provides for a cyclopropane compound having the following chemical formula: wherein α is —H or —COOR, wherein R is —H or an alkyl group, such as —CH3, —CH2CH3, —(CH2)2—CH3, —(CH2)3—CH3, or —C(CH3)3; β is each independently wherein at least one β is and, n is an integer from 3 to 11. A fuel composition comprising the cyclopropane compound thereof and a fuel additive. The present invention also provides for a system or genetically modified host cell capable of producing the cyclopropane compound, and a method for producing the cyclopropane compound.
FILED Tuesday, September 28, 2021
APPL NO 17/449218
CURRENT CPC
Peptides
C07K 14/36 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/16 (20130101)
C12N 1/20 (20130101)
C12N 9/1029 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/002 (20130101) Original (OR) Class
C12P 17/16 (20130101)

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/465 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098631 Shasky et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Novozymes, Inc. (Davis, California)
ASSIGNEE(S) Novozymes, Inc. (Davis, California)
INVENTOR(S) Jeffrey Shasky (Davis, California);  Amanda Fischer (Davis, California);  Suchindra Maiyuran (Gold River, California)
ABSTRACT The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions.
FILED Friday, December 10, 2021
APPL NO 17/547836
CURRENT CPC
Peptides
C07K 14/38 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/2437 (20130101)
C12N 9/2445 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/02 (20130101)
C12P 19/14 (20130101) Original (OR) Class

Enzymes
C12Y 302/01004 (20130101)
C12Y 302/01008 (20130101)
C12Y 302/01021 (20130101)
C12Y 302/01037 (20130101)
C12Y 302/01091 (20130101)
C12Y 302/01176 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 50/10 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 20/52 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098706 Luo et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Alan Luo (Columbus, Ohio);  Emre Cinkilic (Columbus, Ohio);  Michael Moodispaw (Columbus, Ohio)
ABSTRACT Disclosed are aluminum alloys with high iron content and methods of making and using.
FILED Wednesday, September 29, 2021
APPL NO 17/489038
CURRENT CPC
Alloys
C22C 1/026 (20130101)
C22C 21/02 (20130101) Original (OR) Class

Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys
C22F 1/043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098730 Mane et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Anil U. Mane (Naperville, Illinois);  Jeffrey W. Elam (Elmhurst, Illinois);  Seth B. Darling (Chicago, Illinois);  Nestor J. Zaluzec (Bolingbrook, Illinois);  Alex B. Martinson (Naperville, Illinois)
ABSTRACT The sequential infiltration synthesis (SIS) and Atomic Layer Deposition (ALD) of metal and/or metal oxides on personal medical equipment (PPE). The deposited metal and/or metal oxides imbues antimicrobial properties to the PPE.
FILED Wednesday, September 30, 2020
APPL NO 17/039969
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/10 (20130101)
A01N 59/16 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 2/18 (20130101)
A61L 2101/30 (20200801)

Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/40 (20130101)
C23C 16/0272 (20130101)
C23C 16/45527 (20130101) Original (OR) Class
C23C 16/45555 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098734 Elam et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Jeffrey W. Elam (Elmhurst, Illinois);  Anil U. Mane (Naperville, Illinois)
ABSTRACT A secondary electron emissive coating. The coating is formed by atomic layer deposition of CaF2 on a substrate by ALD half cycle exposure of an alkaline metal amidinate and ALD half cycle exposure of a fluorinated compound, where the deposition occurs at a reaction temperature greater than a highest sublimation temperature of the first metal precursor and the second metal precursor and less than 50° C. above the highest sublimation temperature.
FILED Wednesday, September 30, 2020
APPL NO 17/038944
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/22 (20130101)
C23C 16/45553 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098736 Mane et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Anil U. Mane (Naperville, Illinois);  Devika Choudhury (Naperville, Illinois);  Jeffrey W. Elam (Elmhurst, Illinois)
ABSTRACT A lithium boron coating and a method of producing the same. Atomic layer deposition deposits lithium and boron to form a lithium borate layer. The lithium borate maybe deposited as a solid electrolyte.
FILED Wednesday, September 30, 2020
APPL NO 17/039822
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/38 (20130101)
C23C 16/4408 (20130101)
C23C 16/45534 (20130101)
C23C 16/45553 (20130101)
C23C 16/45555 (20130101) Original (OR) Class

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0562 (20130101)
H01M 2300/0068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098741 LI et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  Drexel University (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Yawei LI (Taiyuan, China PRC);  Kenneth Charles NEYERLIN (Arvada, Colorado);  Joshua David Snyder (Sparks, Maryland)
ABSTRACT The present disclosure relates to a composition that includes a solid, a first layer of an ionic liquid including an anion and a cation, a second layer including an ionically conductive ionomer, and a catalyst including a metal positioned on the solid, where the ionic liquid forms a first layer on the solid, the first layer is positioned between the second layer and the solid, and the catalyst is positioned between the solid and the first layer.
FILED Tuesday, September 28, 2021
APPL NO 17/487108
CURRENT CPC
Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 11/053 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098743 Rondinone et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Adam J. Rondinone (Knoxville, Tennessee);  Dale K. Hensley (Kingston, Tennessee);  Seonah Jin (Santa Cruz, California)
ABSTRACT An electrocatalyst comprising (i) carbon nanospikes and (ii) copper alloy nanoparticles containing copper and at least one noble metal and residing on and/or between the carbon nanospikes. Also disclosed herein is a method of producing the electrocatalyst. Also described herein is a method for converting carbon dioxide into hydrocarbons by use of the above-described electrocatalyst. The method for producing hydrocarbons more specifically involves contacting the electrocatalyst with an aqueous solution of a bicarbonate salt while the aqueous solution is in contact with a source of carbon dioxide, and electrically powering the electrocatalyst as a cathode at negative potential condition while the cathode is in electrical communication with a counter electrode electrically powered as an anode, to convert the carbon dioxide into hydrocarbons containing at least four carbon atoms and composed of only carbon and hydrogen.
FILED Wednesday, September 29, 2021
APPL NO 17/488884
CURRENT CPC
Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/03 (20210101)
C25B 3/26 (20210101)
C25B 11/054 (20210101)
C25B 11/065 (20210101)
C25B 11/089 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098985 Chakrabarti et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
National Energy Technology Laboratory (NETL)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Suryarghya Chakrabarti (Mason, Ohio);  Bugra Han Ertas (Niskayuna, New York)
ABSTRACT A vibrational dampening element is attached to a component and configured to adjust the amplitude of oscillations of the component. The vibrational dampening element includes a mass. The mass includes a main body and a member extending from the main body. A casing that encapsulates the mass. A fluidic chamber defined between the mass and the casing. A first fluidic portion is disposed between a first side of the mass and the casing. The first fluidic portion includes a first accumulator portion directly neighboring the member. A second fluidic portion is disposed between a second side of the mass and the casing. The second fluidic portion includes a second accumulator portion directly neighboring the member. The first accumulator portion is in fluid communication with the second accumulator portion. The vibrational dampening element further includes a primary passage that extends between the first fluidic portion and the second fluidic portion.
FILED Wednesday, September 30, 2020
APPL NO 17/038540
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/16 (20130101) Original (OR) Class

Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 3/04 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/30 (20130101)
F05D 2240/35 (20130101)
F05D 2260/96 (20130101)

Springs; Shock-absorbers; Means for Damping Vibration
F16F 15/173 (20130101)
F16F 2222/08 (20130101)
F16F 2232/02 (20130101)
F16F 2234/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098989 Chakrabarti et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
National Energy Technology Laboratory (NETL)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Suryarghya Chakrabarti (Mason, Ohio);  Jing Li (Niskayuna, New York);  John McConnell Delvaux (Fountain Inn, South Carolina)
ABSTRACT A rotor blade assembly includes a first rotor blade and a second rotor blade positioned adjacent to one another. The first rotor blade and the second rotor blade each include a platform and an airfoil extending radially outward from a root coupled to the platform to a tip. The airfoil includes a part-span shroud. The part-span shroud extends from the airfoil and is disposed between the root and the tip. The part-span shroud includes a pressure side portion extending from the pressure side surface and a suction side portion extending from the suction side surface. A damper is in contact with both the part span shroud of the first rotor blade and the part span shroud of the second rotor blade at an interference joint. The damper is movable relative to the part span shroud of both the first rotor blade and the second rotor blade.
FILED Wednesday, September 30, 2020
APPL NO 17/038601
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/225 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/80 (20130101)
F05D 2240/305 (20130101)
F05D 2240/306 (20130101)
F05D 2260/96 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099186 Erdemir et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Ali Erdemir (Naperville, Illinois);  Vanessa DaSilva (Countryside, Illinois);  Osman Levent Eryilmaz (Plainfield, Illinois)
ABSTRACT Systems and processes for forming seals. The seals have graphene embedded in the seal. The graphene-embedded seals exhibit improved wear resistance over seals without graphene.
FILED Tuesday, September 29, 2020
APPL NO 17/036984
CURRENT CPC
Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics
B29B 7/945 (20130101)

Pistons; Cylinders; Sealings
F16J 15/162 (20130101) Original (OR) Class
F16J 15/328 (20130101)
F16J 15/3284 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099244 Preissner et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Curt Alfred Preissner (Chicago, Illinois);  Sunil Jeffrey Bean (Bolingbrook, Illinois);  Volker Rose (Downers Grove, Illinois)
ABSTRACT A method and apparatus are provided for implementing an ultra-high stability stage with combined degrees of freedom for multiple axes of motion. The ultra-high stability stage includes a base, a driving wedge supported by the base and a following wedge supported by the driving wedge. The base and each wedge are formed of a selected stable material having predefined rigidity and low thermal expansion coefficient. Integrated air bearings, respective driving mechanics associated with each of the wedges and guiding components having selected degrees of freedom enable movement about multiple axes of motion, such as X, Y, Z translation axes, and rotation X and rotation Y axes. Another ultra-high stability stage with combined degrees of freedom for multiple axes of motion includes an intermediate wedge between the driving wedge and the following wedge to enable additional movement about a rotation X axis.
FILED Monday, September 28, 2020
APPL NO 17/034133
CURRENT CPC
Frames, Casings or Beds of Engines, Machines or Apparatus, Not Specific to Engines, Machines or Apparatus Provided for Elsewhere; Stands; Supports
F16M 11/24 (20130101) Original (OR) Class
F16M 11/205 (20130101)
F16M 11/2028 (20130101)
F16M 11/2071 (20130101)
F16M 11/2085 (20130101)
F16M 11/2092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099314 Bahar et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Xergy Inc. (Harrington, Delaware)
ASSIGNEE(S)
INVENTOR(S) Bamdad Bahar (Georgetown, Delaware);  William Parmelee (Orleans, Massachusetts);  Omar Abdelaziz (Oak Ridge, Tennessee);  Qu Ming (Oak Ridge, Tennessee)
ABSTRACT A cooling system utilizes an organic ionic salt composition for dehumidification of an airflow. The organic ionic salt composition absorbs moisture from an inlet airflow to produce an outlet airflow with a reduce moisture from that of the inlet airflow. The organic ionic salt composition may be regenerated, wherein the absorbed moisture is expelled by heating with a heating device. The heating device may be an electrochemical heating device, such as a fuel cell, an electrochemical metal hydride heating device, an electrochemical heat pump or compressor, or a condenser of a refrigerant cycle, which may utilize an electrochemical pump or compressor. The efficiency of the cooling system may be increased by utilization of the waste heat the cooling system. The organic ionic salt composition may circulate back and forth or in a loop between a conditioner, where it absorbs moisture, to a regenerator, where moisture is desorbed by heating.
FILED Monday, October 18, 2021
APPL NO 17/503678
CURRENT CPC
Separation
B01D 1/14 (20130101)
B01D 5/0003 (20130101)
B01D 5/009 (20130101)
B01D 5/0027 (20130101)
B01D 5/0039 (20130101)
B01D 5/0087 (20130101)
B01D 53/263 (20130101)
B01D 53/268 (20130101)

Heterocyclic Compounds
C07D 233/58 (20130101)

Compositions of Macromolecular Compounds
C08L 27/12 (20130101)

Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening
F24F 3/001 (20130101)
F24F 3/1417 (20130101) Original (OR) Class
F24F 2003/1458 (20130101)

Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 17/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099342 MOMEN et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) AYYOUB MEHDIZADEH MOMEN (Knoxville, Tennessee);  AHMED ABUHEIBA (Knoxville, Tennessee);  SAIID KASSAEE (Knoxville, Tennessee)
ABSTRACT A gas compressor system includes a compression liquid holding tank in fluid communication with a combustion tank. A combustible fluid is directed to the combustion tank. An ignition system is provided for igniting the combustible fluid. A compression liquid flows between the liquid holding tank, the combustion tank, and a compression tank. A compressible gas is provided in the compression tank. The ignition of the combustible fluid drives the compression liquid from the combustion tank to the compression tank, compressing the compressible liquid. An HVAC&R system and a method of compressing gas are also disclosed.
FILED Monday, August 09, 2021
APPL NO 17/396968
CURRENT CPC
Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 3/04 (20130101)
F02C 6/00 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/70 (20130101)

Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 31/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099366 Holladay et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S) Battelle Memorial Institute (Richland, Washington);  Emerald Energy NW, LLC (Bothell, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington);  Emerald Energy NW, LLC (Bothell, Washington)
INVENTOR(S) Jamie D. Holladay (Richland, Washington);  John Barclay (Richland, Washington)
ABSTRACT A system including: an active magnetic regenerative refrigerator apparatus that includes a high magnetic field section in which a hydrogen heat transfer fluid can flow from a cold side to a hot side through at least one magnetized bed of at least one magnetic refrigerant, and a low magnetic field or demagnetized section in which the hydrogen heat transfer fluid can flow from a hot side to a cold side through the demagnetized bed; a first conduit fluidly coupled between the cold side of the low magnetic field or demagnetized section and the cold side of the high magnetic field section; and a second conduit fluid coupled to the first conduit, an expander and at least one liquefied hydrogen storage module.
FILED Friday, December 10, 2021
APPL NO 17/548267
CURRENT CPC
Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 21/00 (20130101)
F25B 2321/0021 (20130101)

Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment
F25J 1/001 (20130101)
F25J 1/0225 (20130101) Original (OR) Class
F25J 2270/908 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/015 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099377 Sabau et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Adrian S. Sabau (Knoxville, Tennessee);  James W. Klett (Knoxville, Tennessee);  Yarom Polsky (Knoxville, Tennessee)
ABSTRACT A shell and tube heat exchanger has elongated shell having first and second opposing ends and an open interior. A core divides the open interior of the shell into first and second enclosed portions. The shell has first and second tube fluid openings at opposing ends. End plates divide the first and second enclosed portions into manifold portions and enclosed shell chamber portions. Tubes extend from the end plates, through the enclosed shell chambers to the core. Shell fluid openings are at sides of the elongated shell, a first fluid opening communicating with the first shell chamber, and a second fluid opening communicating with the second shell chamber. The shell has a long axis, and the end plates are angled relative to the long axis. The tubes are polygonal with rounded corners and straight sides. The heat exchanger can be used for both evaporation and condensation processes.
FILED Tuesday, September 29, 2020
APPL NO 17/036392
CURRENT CPC
Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact
F28D 7/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099483 Gostein et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Michael Gostein (Austin, Texas);  William Stueve (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Michael Gostein (Austin, Texas);  William Stueve (Austin, Texas)
ABSTRACT In one respect, disclosed is a device or system for solar irradiance measurement comprising at least two irradiance sensors deployed outdoors at substantially different angles, such that, by analysis of readings from said irradiance sensors, a direct irradiance, a diffuse irradiance, a global irradiance, and/or a ground-reflected irradiance are determined. In some embodiments the disclosed device or system is stationary and has no moving parts.
FILED Friday, December 10, 2021
APPL NO 17/547293
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 1/42 (20130101) Original (OR) Class
G01J 2001/428 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099536 Kertesz et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Vilmos Kertesz (Oak Ridge, Tennessee);  Bernadeta R. Srijanto (Knoxville, Tennessee);  Charles P. Collier (Knoxville, Tennessee);  John F. Cahill (Knoxville, Tennessee)
ABSTRACT A method and system for sampling a solid sample material can include the step of mounting the sample material on a support. A sample surface is coated with a surface treatment composition in a dry deposition process. A solvent supply conduit for supplying solvent to the sample surface and a solvent exhaust conduit for withdrawing solvent from the sample surface can be provided. Solvent is flowed from the solvent supply conduit to the surface treatment composition and the sample surface such that the solvent contacts the surface treatment composition. A laser beam is directed from a laser source to the sample and the surface treatment composition. The laser beam will ablate the sample and the surface treatment composition in portions intersected by the laser beam. Ablated sample material enters the solvent liquid and will be transported with the solvent away from the sample surface through the solvent exhaust conduit.
FILED Friday, October 29, 2021
APPL NO 17/514304
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/04 (20130101) Original (OR) Class
G01N 1/38 (20130101)
G01N 2001/045 (20130101)
G01N 2001/383 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/164 (20130101)
H01J 49/0463 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099720 Halligan et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Matthew Halligan (O'Fallon, Missouri);  Tyler Bowman (Albuquerque, New Mexico)
ABSTRACT A series tee splitter comprises a primary electromagnetic transmission line and a secondary electromagnetic transmission line that is placed in a series path with the primary electromagnetic transmission line, wherein a load is attached to the end of the secondary electromagnetic transmission line and a network analyzer is connected to opposite ends of the primary electromagnetic transmission line to measure a load impedance. This configuration increases the high impedance measurement limit of the network analyzer normally seen for reflection measurements. The series tee splitter can be electrically small to provide broadband impedance information.
FILED Monday, September 20, 2021
APPL NO 17/479265
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 27/16 (20130101) Original (OR) Class

Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 9/05 (20130101)
H01R 2201/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100047 Gowda et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Apurva Shantharaj Gowda (Mountain View, California);  Jacky Chak-Kee Chan (Livermore, California);  Peter Thomas Setsuda DeVore (Livermore, California);  David Simon Perlmutter (Oakland, California);  Jason Thomas Chou (Walnut Creek, California)
ABSTRACT Devices, methods and systems for generating wideband, high-fidelity arbitrary radio frequency (RF) passband signals are described. A voltage tunable optical filter for arbitrary RF passband signal generation includes a first input configured to receive a broadband optical pulse train, a second input configured to receive a first control voltage representative of an amplitude signal, an electrooptic modulator to receive the broadband optical pulse train and the first control voltage, to modulate the broadband optical pulse train in accordance with the amplitude signal, and to produce two complementary optical outputs that form two arms of an interferometer, an optical delay component to impart an optical path difference into one of the complementary outputs of the electrooptic modulator, and a combiner or a splitter to receive two complementary optical outputs of the electrooptic modulator after impartation of the optical path difference and to produce an output interference pattern of fringes.
FILED Friday, December 10, 2021
APPL NO 17/548394
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/20 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/21 (20130101) Original (OR) Class
G02F 1/0123 (20130101)
G02F 1/212 (20210101)

Multiplex Communication
H04J 14/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100257 Bharadwaj et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S) Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S) Vedula Venkata Srikant Bharadwaj (Bellevue, Washington);  Shomit N. Das (Austin, Texas);  Anthony T. Gutierrez (Bellevue, Washington);  Vignesh Adhinarayanan (Austin, Texas)
ABSTRACT Systems, methods, devices, and computer-implemented instructions for processor power management implemented in a compiler. In some implementations, a characteristic of code is determined. An instruction based on the determined characteristic is inserted into the code. The code and inserted instruction are compiled to generate compiled code. The compiled code is output.
FILED Friday, September 25, 2020
APPL NO 17/033000
CURRENT CPC
Electric Digital Data Processing
G06F 1/324 (20130101)
G06F 1/3287 (20130101) Original (OR) Class
G06F 1/3296 (20130101)
G06F 9/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100501 Boyer et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Michael W. Boyer (Redmond, Washington);  John Kalamatianos (Acton, Massachusetts);  Pritam Majumder (College Station, Texas)
ABSTRACT An electronic device includes a processor having a micro-operation queue, multiple scheduler entries, and scheduler compression logic. When a pair of micro-operations in the micro-operation queue is compressible in accordance with one or more compressibility rules, the scheduler compression logic acquires the pair of micro-operations from the micro-operation queue and stores information from both micro-operations of the pair of micro-operations into different portions in a single scheduler entry. In this way, the scheduler compression logic compresses the pair of micro-operations into the single scheduler entry.
FILED Sunday, September 27, 2020
APPL NO 17/033883
CURRENT CPC
Electric Digital Data Processing
G06F 9/223 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100506 Kulkarni et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Milind Kulkarni (West Lafayette, Indiana);  Jad Hbeika (Santa Clara, California)
ABSTRACT A graphics processing unit and methods for comping and executing instructions with opportunistic inter-path reconvergence are provided. A graphics processing unit may access computer executable instructions mapped to code blocks of a control flow for a warp. The code blocks may include an immediate dominator block and an intermediate post dominator block. The graphics processing unit may store a first thread mask associated with the first code block. The first thread mask may include a plurality of bits indicative of the active or non-active status for the threads of the warp, respectively. The graphics processing unit may a second thread mask corresponding to an intermediate code block between the immediate dominator block and intermediate post dominator block. The graphics processing unit may execute, with threads indicated as active by the first thread mask, instructions of the intermediate code block with a first operand or a second operand depending on the second thread mask.
FILED Thursday, September 30, 2021
APPL NO 17/491057
CURRENT CPC
Electric Digital Data Processing
G06F 9/3887 (20130101)
G06F 9/30018 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100665 Kotra et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Jagadish Kotra (Austin, Texas);  John Kalamatianos (Arlington, Massachusetts)
ABSTRACT An electronic device includes a processor having a cache memory, a plurality of physical registers, and a promotion logic functional block. The promotion logic functional block promotes prefetched data from a portion of a cache block in the cache memory into a given physical register, the promoting including storing the prefetched data in the given physical register. Upon encountering a load micro-operation that loads data from the portion of the cache block into a destination physical register, the promotion logic functional block sets the processor so that the prefetched data stored in the given physical register is provided to micro-operations that depend on the load micro-operation.
FILED Monday, December 28, 2020
APPL NO 17/135832
CURRENT CPC
Electric Digital Data Processing
G06F 12/0862 (20130101) Original (OR) Class
G06F 2212/602 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100690 CHEN et al.
FUNDED BY
Department of Energy (DOE)
Brookhaven Science Associates, LLC (BSA)
Office of Science (DOE-SC)
Brookhaven National Laboratory (BNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Brookhaven Science Associates, LLC (BSA) at Upton, NY
APPLICANT(S) Brookhaven Science Associates, LLC (Upton, New York)
ASSIGNEE(S)
INVENTOR(S) Kai CHEN (Ridge, New York);  Michael BEGEL (South Setauket, New York);  Hucheng CHEN (Wading River, New York);  Francesco LANNI (Segny, France)
ABSTRACT A reconfigurable data acquisition card including at least one field programmable gate array (FPGA) and a configurable bus switch coupled with the FPGA. The bus switch forms at least first and second ports used by the FPGA, the bus switch being adaptable for insertion into a connection having a number of lanes at least equal to a combined number of lanes in the first and second ports. The data acquisition card further includes multiple optical transmitters and optical receivers. Each optical transmitter and optical receiver is coupled with a corresponding transceiver in the FPGA via at least one optical fiber having multiple communication links. Timing circuitry in the data acquisition card is coupled with clock generation and distribution circuitry in the FPGA and is configured to distribute clock and timing signals to detector front-ends with fixed latency and to synchronize input/output links with a system clock generated by the FPGA.
FILED Monday, September 23, 2019
APPL NO 17/428810
CURRENT CPC
Electric Digital Data Processing
G06F 13/4022 (20130101) Original (OR) Class

Pulse Technique
H03K 19/14 (20130101)

Transmission
H04B 10/40 (20130101)

Multiplex Communication
H04J 3/0685 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101945 Garvin et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Michael R. Garvin (Oak Ridge, Tennessee);  Daniel A. Jacobson (Oak Ridge, Tennessee);  David Kainer (Oak Ridge, Tennessee);  Erica Teixeira Prates (Oak Ridge, Tennessee)
ABSTRACT The present disclosure is directed to methods of identifying structural variants (SVs) from single nucleotide polymorphisms (SNPs) that demonstrate non-Mendelian inheritance pattern (NMI) and finding the biological relevance of the SVs through machine learning. Also disclosed are processors programmed to identify biologically-relevant SVs and computer-readable storage devices comprising instructions to identify biologically-relevant SVs.
FILED Tuesday, September 28, 2021
APPL NO 17/487188
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201) Original (OR) Class
G16B 30/00 (20190201)
G16B 40/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102040 Hahn et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
National High Magnetic Field Laboratory (NHMFL)
APPLICANT(S) Seungyong Hahn (Tallahassee, Florida);  David Larbalestier (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Seungyong Hahn (Tallahassee, Florida);  David Larbalestier (Tallahassee, Florida)
ABSTRACT An active feedback controller for a power supply current of a no-insulation (NI) high-temperature superconductor (HTS) magnet to reduce or eliminate the charging delay of the NI HTS magnet and to linearize the magnet constant.
FILED Tuesday, July 27, 2021
APPL NO 17/386517
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/3815 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/006 (20130101)
H01F 6/06 (20130101)
H01F 6/008 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102096 Li et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Eaton Intelligent Power Limited (Dublin 4, Ireland)
ASSIGNEE(S)
INVENTOR(S) Wangpei Li (Horseheads, New York);  Xin Zhou (Wexford, Pennsylvania)
ABSTRACT A vacuum interrupter having a structure to trap running cathode tracks is disclosed. The interrupter includes a first electrode assembly and a second electrode assembly, at least one of which is moveable. The interrupter also includes a sidewall having a longitudinal axis. One or more trench structures are formed in at least one of the electrode assemblies. Each trench structure has an opening that faces the other electrode assembly in a direction that is parallel to the longitudinal axis, to trap the running cathode tracks to prevent them from getting close to the sidewall.
FILED Wednesday, September 30, 2020
APPL NO 17/038387
CURRENT CPC
Electric Switches; Relays; Selectors; Emergency Protective Devices
H01H 33/664 (20130101)
H01H 33/66207 (20130101) Original (OR) Class
H01H 33/66238 (20130101)
H01H 33/66261 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102127 Kertesz et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Vilmos Kertesz (Oak Ridge, Tennessee);  John F. Cahill (Knoxville, Tennessee)
ABSTRACT A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.
FILED Monday, September 20, 2021
APPL NO 17/480094
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/0031 (20130101)
H01J 49/165 (20130101)
H01J 49/0445 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102578 STEINER
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Myles Aaron STEINER (Denver, Colorado)
ABSTRACT The present disclosure relates to a method that includes depositing a spalling layer onto a surface that includes a substrate, depositing a device comprising a III-V material onto the spalling layer, resulting in the forming of a stack, and dividing the stack substantially at a plane positioned within the spalling layer to form a first portion that includes the substrate and a second portion that includes the PV device, where the spalling layer includes a first layer configured to provide a compressive stress and a second layer configured to provide a tensile stress, the first layer and the second layer form an interface, the dividing occurs as result of the interface, and the compressive stress and the tensile stress are strain-balanced so that a total strain within the spalling layer is approximately zero.
FILED Friday, September 24, 2021
APPL NO 17/484578
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/0392 (20130101)
H01L 31/0735 (20130101)
H01L 31/1844 (20130101)
H01L 31/1892 (20130101) Original (OR) Class
H01L 31/03046 (20130101)
H01L 33/12 (20130101)
H01L 33/30 (20130101)
H01L 33/0062 (20130101)
H01L 33/0093 (20200501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102580 Reilly et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Caroline E. Reilly (Goleta, California);  Umesh K. Mishra (Montecito, California);  Stacia Keller (Santa Barbara, California);  Steven P. DenBaars (Goleta, California)
ABSTRACT A method for fabricating a device, as well as the device itself, which includes growing a bonding layer on a first wafer or substrate, wherein the bonding layer includes at least partially relaxed features; and then bonding a second wafer or substrate to the features in on the first wafer or substrate, to cap and contact the features with separately grown material.
FILED Thursday, January 16, 2020
APPL NO 17/422867
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/1848 (20130101)
H01L 31/1892 (20130101)
H01L 33/025 (20130101)
H01L 33/0093 (20200501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102726 Jun et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  Lawrence Berkeley National Laboratory (Berkeley, California)
INVENTOR(S) KyuJung Jun (Albany, California);  Gerbrand Ceder (Orinda, California);  Yingzhi Sun (Albany, California);  Yan Wang (Brookline, Massachusetts);  Lincoln Miara (Lincoln, Massachusetts);  Yan Zeng (Albany, California);  Yihan Xiao (Berkeley, California)
ABSTRACT A solid-state ion conductor including a compound of Formula 1:
Li(3+2y1)B(P1-y1A1y1O4)2   Formula 1 wherein, in Formula 1, A1 is an element of Groups 4, 14, or a combination thereof, and has an oxidation state of +4, and 0<y1<1.
FILED Monday, May 17, 2021
APPL NO 17/321714
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/5825 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102744 ANDO et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) TOYOTA JIDOSHA KABUSHIKI KAISHA (Toyota-shi, Japan);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Masaki ANDO (Gotemba-shi, Japan);  Toshihiko YOSHIDA (Fujimi-shi, Japan);  Adam Z. WEBER (Berkeley, California)
ABSTRACT A fuel cell system comprising: a fuel cell, a fuel gas supplier configured to supply fuel gas to an anode of the fuel cell, an oxidant gas supplier configured to supply oxidant gas to a cathode of the fuel cell, a humidity adjuster configured to adjust a relative humidity of the fuel gas and a relative humidity of the oxidant gas, and a controller, wherein the controller detects the relative humidity of the fuel gas at an anode inlet of the fuel cell, and the controller detects the relative humidity of the oxidant gas at a cathode outlet of the fuel cell, and wherein, based on detection results, the controller controls the humidity adjuster so that the relative humidity of the fuel gas at the anode inlet is higher than the relative humidity of the oxidant gas at the cathode outlet.
FILED Wednesday, September 29, 2021
APPL NO 17/488408
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/045 (20130101)
H01M 8/04119 (20130101)
H01M 8/04507 (20130101)
H01M 8/04835 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220103191 Ganapathy et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Shrikanth Ganapathy (Santa Clara, California);  John Kalamatianos (Boxborough, Massachusetts)
ABSTRACT Systems, apparatuses, and methods for implementing masked fault detection for reliable low voltage cache operation are disclosed. A processor includes a cache that can operate at a relatively low voltage level to conserve power. However, at low voltage levels, the cache is more likely to suffer from bit errors. To mitigate the bit errors occurring in cache lines at low voltage levels, the cache employs a strategy to uncover masked faults during runtime accesses to data by actual software applications. For example, on the first read of a given cache line, the data of the given cache line is inverted and written back to the same data array entry. Also, the error correction bits are regenerated for the inverted data. On a second read of the given cache line, if the fault population of the given cache line changes, then the given cache line's error protection level is updated.
FILED Thursday, December 17, 2020
APPL NO 17/125145
CURRENT CPC
Electric Digital Data Processing
G06F 11/1064 (20130101)
G06F 12/0895 (20130101)
G06F 2212/1032 (20130101)

Coding; Decoding; Code Conversion in General
H03M 13/353 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220104338 Ebrahimi
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Princeton Plasma Physics Laboratory (PPPL)
Federally Funded Research and Development Center (FFRDC)
Operated by Princeton University (PRINCETON) at Princeton, NJ
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Fatima Arezu Ebrahimi (Princeton, New Jersey)
ABSTRACT According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap. A total Lorentz force causes oppositely directed magnetic field lines to be expanded around a region of the gas injector to further create an azimuthal current in the form of an axially elongated current sheet that is unstable such that the axially elongated current sheet reconnects and breaks into plasmoids.
FILED Wednesday, September 29, 2021
APPL NO 17/488986
CURRENT CPC
Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/06 (20130101)

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/54 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20220095962 SRIDHARAN et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Arizona Board of Regents on behalf of Arizona Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Arati SRIDHARAN (Chandler, Arizona);  Jitendran MUTHUSWAMY (Chandler, Arizona)
ABSTRACT A soft conductive composite composition can include a soft matrix containing a conductive member that is associated with a bioactive component. The soft matrix can be formed from a silicone composition. The conductive member can be carbon nanotubes in the silicone composition. The carbon nanotubes can have at least two walls and be conductive. Also, the carbon nanotubes can be a mixture of functionalized carbon nanotubes and non-functionalized carbon nanotubes, which mixture can have a ratio of 1:2 to 1:20 w/w of functionalized to non-functionalized carbon nanotubes per gram of the silicone composition. The bioactive component (e.g., enzyme) can be associated with at least a first portion of the carbon nanotubes. A second portion of the carbon nanotubes can be devoid of the bioactive component.
FILED Friday, January 31, 2020
APPL NO 17/426497
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0537 (20130101)
A61B 5/0538 (20130101)
A61B 5/1473 (20130101) Original (OR) Class
A61B 5/6868 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096402 Koppisch et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Office of Advanced Cyberinfrastructure (OAC)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Phoenix, Arizona);  DIXIE STATE UNIVERSITY (St. George, Utah);  TRIAD NATIONAL SECURITY, LLC (Los Alamos, New Mexico);  COLLEGE OF NEW JERSEY (Ewing, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Andrew T. Koppisch (Flagstaff, Arizona);  Gerrick E. Lindberg (Flagstaff, Arizona);  David T. Fox (Los Alamos, New Mexico);  Joseph Baker (Ewing, New Jersey);  Alexanndra J. Heyert (Flagstaff, Arizona);  Rico Del Sesto (St. George, Utah);  Joshua R. Greene (Flagstaff, Arizona)
ABSTRACT Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.
FILED Wednesday, December 01, 2021
APPL NO 17/457176
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 27/00 (20130101)
A01N 37/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/01 (20130101)
A61K 31/11 (20130101)
A61K 31/14 (20130101) Original (OR) Class
A61K 31/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096411 Bening et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Sarah Bening (Cambridge, Massachusetts);  Meagan Hamblin (Cambridge, Massachusetts);  Ian Andrews (Cambridge, Massachusetts);  Allison Lopatkin (Cambridge, Massachusetts);  James Collins (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides compositions and methods capable of potentiating the effects of antibiotics against bacterial infections that either have developed, or that possess the potential to develop, antibiotic tolerance. Methods of sensitizing antibiotic tolerant bacteria to antibiotics, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at antibiotic tolerant bacteria are also provided.
FILED Thursday, January 23, 2020
APPL NO 17/425438
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/46 (20130101)
A61K 31/198 (20130101) Original (OR) Class
A61K 31/407 (20130101)
A61K 31/424 (20130101)
A61K 31/431 (20130101)
A61K 31/546 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096539 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia);  The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Jin Xie (Athens, Georgia);  Wen Jiang (Athens, Georgia);  Trever Todd (Fountain Valley, California);  Zibo Li (Chapel Hill, North Carolina)
ABSTRACT Particles formed from an alkai metal or alkaline earth metal and halide, for example, sodium and chloride, are provided. The particles can have a hydrophilic coating or external layer, formed of, for example, a polyether-lipid conjugate. In preferred embodiments, the lipid is a phospholipid such as a phosphoethanolamine, and the polyether is a polyethylene glycol such as a PEG amine. Methods making the particles by, for example, a microemulsion reaction, are also provided. Pharmaceutical compositions including a plurality of particles and a pharmaceutically acceptable carrier are also disclosed. Typically the compositions include an effective amount of particles to treat a disease or condition, particularly cancer, in a subject in need thereof. The particles are typically nanoparticles, for example, between about 10 nm and 250 nm and can be monodisperse.
FILED Friday, January 17, 2020
APPL NO 17/424109
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5015 (20130101)
A61K 33/14 (20130101) Original (OR) Class
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)
A61K 2039/5152 (20130101)
A61K 2039/55505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096645 CAMACHO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Kathryn M. CAMACHO (Los Angeles, California);  Stefano MENEGATTI (Raleigh, North Carolina);  Sunny KUMAR (Aliso Viejo, California);  Douglas VOGUS (Goleta, California);  Samir MITRAGOTRI (Lexington, Massachusetts)
ABSTRACT Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker.
FILED Thursday, December 09, 2021
APPL NO 17/546480
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/704 (20130101)
A61K 31/4745 (20130101)
A61K 31/7068 (20130101)
A61K 47/61 (20170801) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096709 Rabbani et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) New York University (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Piul Rabbani (Brooklyn, New York);  Joseph Kuhn (Brooklyn, New York);  Jin Kim Montclare (New York, New York);  Priya Katyal (Mineola, New York);  Michael Meleties (Whitestone, New York);  Juan Francisco Cortes Troncoso (Santiago, Chile)
ABSTRACT Provided are hydrogel-based compositions and materials for wound healing and methods of using same. The hydrogel comprises nanofibers formed from protein Q, which is a variant of the cartilage oligomeric matrix protein coiled coil (COMPcc) protein, or a protein having at least 85% homology with protein Q. The hydrogel has one or more wound healing agents distributed therein and associated with the Q fibers. The wound healing agent may be exosomes, which may be exosomes produced by cells, such as exosomes produced by multipotent stromal cells and/or one or more triterpenoids. The hydrogels may be used in treatment of wounds, such as chronic wounds.
FILED Thursday, September 30, 2021
APPL NO 17/490156
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4164 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 26/008 (20130101)
A61L 26/0047 (20130101) Original (OR) Class
A61L 26/0066 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0669 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096834 WANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Qi WANG (New York, New York);  Charles RODENKIRCH (New York, New York)
ABSTRACT Methods and devices for modifying sensory processing in a subject are provided. Aspects are directed to applying tonic vagus nerve stimulation to a subject for transient sensory processing modification. Devices for applying tonic vagus nerve stimulation when a subject is in need of sensory modification or on demand are also provided. The devices can be coupled with a prosthetic device for application to regions of the body in need of vagus nerve stimulation.
FILED Friday, December 10, 2021
APPL NO 17/547436
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36025 (20130101) Original (OR) Class
A61N 1/36031 (20170801)
A61N 1/36034 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220096860 Chamanzar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Maysamreza Chamanzar (Pittsburgh, Pennsylvania);  Jay W. Reddy (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is a fully flexible photonic platform based on a high density, flexible array of ultra-compact optical waveguides composed of biocompatible polymers Parylene C and PDMS. The photonic platform features unique embedded input/output micro-mirrors that redirect light from the waveguides perpendicularly to the surface of the array for localized, patterned illumination in tissue. This architecture enables the design of a fully flexible, compact integrated photonic system to realize an implantable, wearable or on-chip photonic platform for application such as in vivo chronic optogenetic stimulation of brain activity.
FILED Monday, September 27, 2021
APPL NO 17/486351
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/067 (20210801)
A61N 5/0601 (20130101) Original (OR) Class
A61N 5/0622 (20130101)
A61N 2005/063 (20130101)
A61N 2005/0643 (20130101)
A61N 2005/0666 (20130101)

Optical Elements, Systems, or Apparatus
G02B 6/4214 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/0005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097067 Weitz et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) David A. Weitz (Cambridge, Massachusetts);  Darren Roy Link (Cambridge, Massachusetts);  Manuel Marquez-Sanchez (Cambridge, Massachusetts);  Zhengdong Cheng (Cambridge, Massachusetts)
ABSTRACT This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
FILED Thursday, September 09, 2021
APPL NO 17/470927
CURRENT CPC
Mixing, e.g Dissolving, Emulsifying, Dispersing
B01F 5/0682 (20130101)
B01F 13/0062 (20130101)
B01F 13/0071 (20130101)
B01F 13/0076 (20130101)
B01F 2215/0431 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 2/04 (20130101)

Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101)
B01L 3/502715 (20130101)
B01L 3/502784 (20130101) Original (OR) Class
B01L 2200/0673 (20130101)
B01L 2300/0867 (20130101)
B01L 2400/02 (20130101)
B01L 2400/0415 (20130101)
B01L 2400/0424 (20130101)

Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 5/03 (20130101)
B05B 7/061 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097240 Jiang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Hanqing Jiang (Chandler, Arizona);  Zirui Zhai (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Hanqing Jiang (Chandler, Arizona);  Zirui Zhai (Tempe, Arizona)
ABSTRACT A curved origami-based metamaterial includes a panel of material having a plurality of curved creases each disposed within a plane of the panel. The panel is configured to be folded along one of the plurality of creases, and the panel is also configured to be bent about an axis disposed outside the plane of the panel. Stiffness manipulation is configured to be achieved in situ by activating a different one of the plurality of curved creases
FILED Wednesday, September 29, 2021
APPL NO 17/449351
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 15/0033 (20130101) Original (OR) Class

Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 5/00 (20130101)
B63B 35/00 (20130101)
B63B 2231/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097292 HOELZLE et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) David J. HOELZLE (Columbus, Ohio);  Desmond M. D'SOUZA (Columbus, Ohio);  Andrej SIMEUNOVIC (Columbus, Ohio);  Ali Asghari ADIB (Columbus, Ohio)
ABSTRACT The present disclosure provides methods for freeform extrusion-based additive manufacturing via a robotic arm. In specific aspects, methods are particularly provided for minimally invasive, intracorporeal three-dimensional printing of biocompatible materials. An end effector of a robotic arm includes a sharp member and a reservoir filled with a printing material. The provided method may include piercing a substrate with the sharp member. A bulb or microbolus of material may be extruded beneath the substrate surface to act as an anchor. The end effector may be manipulated to extrude biomaterial along a printing path. Periodically along the printing path, the sharp member is used to pierce the substrate surface create additional respective anchors. In some instances, the method may terminate after extruding material to form a single layer construct. In other instances, the method includes forming one or more layers on top of the initial base layer anchored to the substrate.
FILED Friday, April 03, 2020
APPL NO 17/600950
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801) Original (OR) Class

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2105/0061 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098037 Groves et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S) John T. Groves (Princeton, New Jersey);  Roy Xiao (Princeton, New Jersey)
ABSTRACT Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2 to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
FILED Tuesday, December 14, 2021
APPL NO 17/550448
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 2/18 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/26 (20130101)
B01J 31/2295 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 11/024 (20130101) Original (OR) Class

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/76 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/025 (20130101)

Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor
D21C 9/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098548 Yarmush et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Martin Yarmush (Newton, Massachusetts);  Basak E. Uygun (Cambridge, Massachusetts);  Korkut Uygun (Boston, Massachusetts);  Maria-Louisa Izamis (Boston, Massachusetts);  Alejandro Soto-Gutierrez (Boston, Massachusetts);  Herman Tolboom (Zurich, Switzerland);  Hiroshi Yagi (Brookline, Massachusetts);  Carley Shulman (Sudbury, Massachusetts);  Jack Milwid (Denver, Colorado)
ABSTRACT One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
FILED Friday, October 01, 2021
APPL NO 17/449762
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/021 (20130101)
A01N 1/0247 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/407 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 1/14 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/067 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098706 Luo et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Alan Luo (Columbus, Ohio);  Emre Cinkilic (Columbus, Ohio);  Michael Moodispaw (Columbus, Ohio)
ABSTRACT Disclosed are aluminum alloys with high iron content and methods of making and using.
FILED Wednesday, September 29, 2021
APPL NO 17/489038
CURRENT CPC
Alloys
C22C 1/026 (20130101)
C22C 21/02 (20130101) Original (OR) Class

Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys
C22F 1/043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099574 Simpson et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
ASSIGNEE(S) PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S) Garth Jason Simpson (West Lafayette, Indiana);  Andreas C. Geiger (Columbia City, Indiana)
ABSTRACT Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.
FILED Tuesday, September 28, 2021
APPL NO 17/487981
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6402 (20130101)
G01N 21/6408 (20130101) Original (OR) Class
G01N 21/6428 (20130101)
G01N 21/6458 (20130101)
G01N 2201/06113 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/16 (20130101)
G02B 21/365 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099581 WEI et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Wei David WEI (Gainesville, Florida);  Jingjing QIU (Daly City, California)
ABSTRACT Embodiments of the present disclosure provide plasmonic structures, methods of making plasmonic structures, and the like.
FILED Tuesday, December 14, 2021
APPL NO 17/550291
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/127 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/553 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099649 Caldona et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Mississippi State University (Starkville, Mississippi)
ASSIGNEE(S)
INVENTOR(S) Eugene B. Caldona (Knoxville, Tennessee);  David O. Wipf (Starkville, Mississippi);  Dennis W. Smith, JR. (Starkville, Mississippi);  Summer L. Nash (Brandon, Mississippi)
ABSTRACT A sensing device is provided. The sensing device includes a base material comprising metal, metalized polymer, or a combination thereof; a first coating layer over the base material, the first coating layer comprising polystyrene; and a second coating layer over the first coating layer, the second coating layer comprising a fluorinated silane-modified polystyrene. Also provided are a method of making the sensing device and a method of electrochemical detection of an analyte in a liquid using the sensing device.
FILED Thursday, September 30, 2021
APPL NO 17/491003
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/026 (20130101)
G01N 27/38 (20130101)
G01N 33/1833 (20130101) Original (OR) Class
G01N 33/1886 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099675 CHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Xiahui CHEN (Mesa, Arizona);  Shoukai KANG (Seattle, Washington);  Md Ashif IKBAL (Tempe, Arizona);  Zhi ZHAO (Mesa, Arizona);  Liangcai GU (Seattle, Washington);  Chao WANG (Chandler, Arizona)
ABSTRACT Provided herein are methods of detecting Ebola virus in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first or second epitopes of glycoproteins, such as secreted glycoproteins (sGPs) from the Ebola virus under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first or second epitopes of the glycoproteins from the Ebola virus in the sample to produce bound glycoproteins. The methods also include detecting the glycoproteins from the Ebola virus when aggregations of the bound glycoproteins form with one another. Related reaction mixtures, devices, kits, and systems are also provided.
FILED Wednesday, September 29, 2021
APPL NO 17/489273
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/78 (20130101)
G01N 33/54326 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101) Original (OR) Class
G01N 2333/08 (20130101)
G01N 2469/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101173 ALEXANDER et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) UNM Rainforest Innovations (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Rafael ALEXANDER (Albuquerque, New Mexico);  Nick MENICUCCI (Melbourne, Australia);  Ben BARAGIOLA (Melbourne, Australia);  Giacomo PANTALEONI (Melbourne, Australia);  Angela KARANJAI (Sydney, Australia)
ABSTRACT Applying Gottesman-Kitaev-Preskill (GKP) error correction to Gaussian input states, such as vacuum, produces distillable magic states, achieving universality without additional non-Gaussian elements. Gaussian operations are sufficient for fault-tolerant, universal quantum computing given a supply of GKP-encoded Pauli eigenstates.
FILED Friday, February 21, 2020
APPL NO 17/426466
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/60 (20220101)
G06N 10/70 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101627 Pappas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) George J. Pappas (Philadelphia, Pennsylvania);  Hamed Hassani (Philadelphia, Pennsylvania);  Alexander Robey (Philadelphia, Pennsylvania)
ABSTRACT Methods, systems, and computer readable media for model-based robust deep learning. In some examples, a method includes obtaining a model of natural variation for a machine learning task. The model of natural variation includes a mapping that specifies how an input datum can be naturally varied by a nuisance parameter. The method includes training, using the model of natural variation and training data for the machine learning task, a neural network to complete the machine learning task such that the neural network is robust to natural variation specified by the model of natural variation.
FILED Thursday, June 03, 2021
APPL NO 17/337972
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)

Image or Video Recognition or Understanding
G06V 10/72 (20220101)
G06V 10/7747 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102639 Perkins et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Cory K. Perkins (Corvallis, Oregon);  Douglas A. Keszler (Corvallis, Oregon)
ABSTRACT Reagents and aqueous solutions thereof are described that are useful for aqueous processing to form thin films comprising metal oxides. A film, or layered film, may be incorporated into working devices where the thin film provides useful optical properties, electrical properties, or both.
FILED Thursday, December 09, 2021
APPL NO 17/546729
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0021 (20130101) Original (OR) Class
H01L 51/56 (20130101)
H01L 51/5206 (20130101)
H01L 2251/306 (20130101)
H01L 2251/308 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220102759 Wu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S) OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
INVENTOR(S) Yiying Wu (Columbus, Ohio);  William McCulloch (Columbus, Ohio)
ABSTRACT The present technology is directed to fluorinated alkylsulfonamide electrolyte salts with high solubility, conductivity, and electrochemical stability as well as batteries incorporating fluorinated alkylsulfonamide salts. In any aspect and/or embodiment herein of the present technology, the battery may include a separator disposed between the cathode and the anode. The separator may be a porous paper, porous ceramic, or porous polymer separator.
FILED Monday, January 06, 2020
APPL NO 17/418644
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/48 (20130101)
H01M 4/583 (20130101)
H01M 4/621 (20130101)
H01M 10/0568 (20130101) Original (OR) Class
H01M 2004/021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220103172 Mundhada et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
APPLICANT(S) Yale University (New Haven, Connecticut)
ASSIGNEE(S) Yale University (New Haven, Connecticut)
INVENTOR(S) Shantanu Mundhada (New Haven, Connecticut);  Nicholas Frattini (New Haven, Connecticut);  Shruti Puri (New Flaven, Connecticut);  Shyam Shankar (New Haven, Connecticut);  Steven M. Girvin (Hamden, Connecticut);  Michel Devoret (New Haven, Connecticut)
ABSTRACT Parametrically pumped four-wave mixing is a key building block for many developments in the field of superconducting quantum information processing. However, undesired frequency shifts such as Kerr, cross-Ken and Stark shifts inherent with four-wave mixing, lead to difficulties in tuning up the desired parametric processes and, for certain applications, severely limit the fidelities of the resulting operations. Some embodiments include a Josephson four-wave mixing device consisting of a SQUID transmon coupled to a half-flux biased SNAIL transmon, a.k.a. capacitively shunted flux qubit. When the two transmon have matching frequencies, an interference effect cancels the negative Kerr of the SQUID transmon with the positive Kerr of the SNAIL transmon while preserving parametric four-wave mixing capabilities.
FILED Wednesday, January 15, 2020
APPL NO 17/423631
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/18 (20130101)
H01L 39/025 (20130101)

Pulse Technique
H03K 17/92 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220103264 Babakhani et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Aydin Babakhani (Los Angeles, California);  Babak Jamali (Los Angeles, California)
ABSTRACT Systems and methods in accordance with embodiments of the invention implement electronic frequency-comb detector systems. One embodiment includes an electronic frequency-comb detector, where the electronic frequency-comb detector includes: a frequency-comb generator configured to generate a frequency comb reference signal, and a heterodyne mixer. In addition, the heterodyne mixer is configured to use the frequency comb reference signal to downconvert received millimeter wave (mm-wave) and terahertz (THZ) frequency tones into an intermediate frequency (IF) signal. In a further embodiment, the electronic frequency-comb detector includes an IF amplifier, where the IF amplifier is configured to feed a spectrum analyzer configured to detect a signature of a material under test (MUT).
FILED Tuesday, January 28, 2020
APPL NO 17/426528
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 2203/56 (20130101)

Transmission
H04B 10/61 (20130101)
H04B 10/90 (20130101) Original (OR) Class
H04B 10/501 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20220097021 VAUGHN et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) STEVEN F VAUGHN (PEORIA, Illinois);  MARK A BERHOW (PEORIA, Illinois);  SEAN X LIU (DUNLAP, Illinois);  JILL K MOSER (MORTON, Illinois);  GORDON W SELLING (DUNLAP, Illinois);  WILLIAM T HAY (DUNLAP, Illinois);  CHRISTOPHER D SKORY (WASHINGTON, Illinois);  STEVEN C PETERSON (WASHINGTON, Illinois)
ABSTRACT The invention relates to absorbent compositions comprising soybean hulls and soybean hull biochar, methods of preparing such absorbent compositions, and methods of using such compositions in the preparation of articles of manufacture.
FILED Thursday, September 23, 2021
APPL NO 17/483489
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 1/0155 (20130101)

Household or Table Equipment
A47G 9/10 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/20 (20130101)
B01J 20/24 (20130101) Original (OR) Class
B01J 20/0237 (20130101)
B01J 20/0266 (20130101)
B01J 20/2803 (20130101)
B01J 20/3042 (20130101)
B01J 20/28016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098146 HART-COOPER et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia);  Method Products, PBC (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) WILLIAM M. HART-COOPER (RICHMOND, California);  WILLIAM J. ORTS (BURLINGAME, California);  AUBRI J. THOMPSON (OAKLAND, California);  KAJ A. JOHNSON (SAUSALITO, California)
ABSTRACT Disclosed are compositions containing a UV-inhibitor, optionally a carrier, and optionally anions; wherein the UV-inhibitor is at least one compound of formula (I) wherein R1 is an aryl derivative, N-acyl, guanidine or aminoguanidine group, and R2 and R3 are independently an aryl group substituted with a straight or branched chain alkyl or an electron donating or withdrawing group. Also disclosed are methods for protecting a product from UV light, involving applying to said product, in an amount sufficient to protect said product from UV light, the composition. Furthermore, there is disclosed methods for providing a reversible dye to a product, involving applying to said product, in an amount sufficient to provide a visible color to said product, the composition.
FILED Monday, September 27, 2021
APPL NO 17/485744
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 281/18 (20130101) Original (OR) Class

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 67/0071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098242 ZHU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Xiaoping ZHU (Clarksville, Maryland);  Weizhong LI (College Park, Maryland);  Tao WANG (Ellicott City, Maryland)
ABSTRACT Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-CoV-2 or at risk of being exposed to SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein.
FILED Friday, February 26, 2021
APPL NO 17/187214
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098543 Gonzalez et al.
FUNDED BY
Department of Agriculture (USDA)
Animal and Plant Health Inspection Service (APHIS)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)
INVENTOR(S) Carlos F. Gonzalez (College Station, Texas);  Stephen J. Ahem (College Station, Texas);  Mayukh Das (College Station, Texas);  Ryland F. Young, III (College Station, Texas);  Tushar Suvra Bhowmick (College Station, Texas)
ABSTRACT Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
FILED Friday, October 08, 2021
APPL NO 17/497582
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 63/40 (20200101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/00 (20130101) Original (OR) Class
C12N 7/00 (20130101)
C12N 15/8281 (20130101)
C12N 2795/10121 (20130101)
C12N 2795/10131 (20130101)
C12N 2795/10221 (20130101)
C12N 2795/10231 (20130101)
C12N 2795/10321 (20130101)
C12N 2795/10331 (20130101)

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/91 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098558 BRIGGS et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) ROBERT E BRIGGS (BOONE, Iowa);  FRED M TATUM (NEVADA, Iowa)
ABSTRACT The present invention provides novel attenuated Pasteurella multocida strains that may be used, in live or killed form, to formulate vaccines that are highly protective against P. multocida infection in bovines, other mammals, and in birds. The present invention also identifies the combination of nanP and hyaC gene mutations as key to the provision of such vaccines. When appropriately formulated, antigenic material of numerous other bovine pathogens may be combined with the live attenuated Pasteurella multocida strains, to make effective combination vaccines.
FILED Friday, September 17, 2021
APPL NO 17/478023
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/102 (20130101)
A61K 2039/552 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0006 (20130101) Original (OR) Class
C12N 9/16 (20130101)

Enzymes
C12Y 101/01022 (20130101)
C12Y 301/03029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20220097067 Weitz et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) David A. Weitz (Cambridge, Massachusetts);  Darren Roy Link (Cambridge, Massachusetts);  Manuel Marquez-Sanchez (Cambridge, Massachusetts);  Zhengdong Cheng (Cambridge, Massachusetts)
ABSTRACT This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
FILED Thursday, September 09, 2021
APPL NO 17/470927
CURRENT CPC
Mixing, e.g Dissolving, Emulsifying, Dispersing
B01F 5/0682 (20130101)
B01F 13/0062 (20130101)
B01F 13/0071 (20130101)
B01F 13/0076 (20130101)
B01F 2215/0431 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 2/04 (20130101)

Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101)
B01L 3/502715 (20130101)
B01L 3/502784 (20130101) Original (OR) Class
B01L 2200/0673 (20130101)
B01L 2300/0867 (20130101)
B01L 2400/02 (20130101)
B01L 2400/0415 (20130101)
B01L 2400/0424 (20130101)

Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 5/03 (20130101)
B05B 7/061 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220097873 Cheng et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Maxar Space LLC (Palo Alto, California)
ASSIGNEE(S) Maxar Space LLC (Palo Alto, California)
INVENTOR(S) Haifei Cheng (Mountain View, California);  Timothy Lofquist (Sunnyvale, California)
ABSTRACT A satellite includes a plurality of thrusters disposed about the satellite, each of the plurality of thrusters having a minimum thruster firing time, and a control circuit connected to the plurality of thrusters. The control circuit is configured to identify violations of the minimum thruster firing time in a non-compliant thruster firing pattern selected to achieve a specified movement, generate a plurality of compliant thruster firing patterns by replacing each of the violations of the non-compliant thruster firing pattern by zero and a minimum time in different combinations, select a compliant thruster firing pattern from the plurality of compliant thruster firing patterns to produce a satellite movement that is within a predetermined range of the specified movement, and cause the plurality of thrusters to fire according to the compliant thruster firing pattern.
FILED Wednesday, September 30, 2020
APPL NO 17/038213
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/10 (20130101)
B64G 1/26 (20130101) Original (OR) Class
B64G 1/40 (20130101)
B64G 2001/247 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220098861 FERNANDEZ
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Juan M. FERNANDEZ (Norfolk, Virginia)
ABSTRACT Various embodiments provide for bistable collapsible tubular mast (Bi-CTM) booms. Various embodiments provide CTM booms that may be bistable in nature, thereby achieving intrinsic benefits bistability may bring. Bistability may be achieved in various embodiments through specific combinations of the thin-shell cross-section geometry and the composite laminate selected for each thin-shell segment. Additionally, in various embodiments, the thin-shell geometry of each boom half may be different. Various embodiments may include combinations of circular, ellipsoidal, or parabolic segments that form each shell.
FILED Monday, December 13, 2021
APPL NO 17/549153
CURRENT CPC
Structural Elements; Building Materials
E04C 2/296 (20130101)
E04C 3/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220099429 Bathel et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Brett F. Bathel (Yorktown, Virginia);  Joshua M. Weisberger (Newport News, Virginia)
ABSTRACT An adjustable beam directing optical system for a focused laser differential interferometer (FLDI) instrument according to various aspects of the present technology may include an optical half waveplate to achieve an incident linear polarization orientation with equal components of laser intensity aligned to the vertical and horizontal axis of the optical system, and an optical prism for splitting these components of an incident laser beam into two orthogonally-polarized beams equally about an optical axis of the FLDI instrument. A series of beam realignment devices positioned downstream of the optical prism are configured to selectively direct each beam to a predetermined location.
FILED Friday, September 25, 2020
APPL NO 17/032341
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02001 (20130101)
G01B 9/02015 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 5/3083 (20130101)
G02B 7/003 (20130101)
G02B 7/1805 (20130101)
G02B 27/285 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100930 DOGGETT et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) William R. DOGGETT (POQUOSON, Virginia);  BRACE W/ WHITE (POQUOSON, Virginia);  JOHN T. DORSEY (YORK TOWN, Virginia);  JULIA E. CLINE (YORKTOWN, Virginia);  DAVID KANG (MCLEAN, Virginia);  KYONGCHAN SONG (POQUOSON, Virginia);  JOHN E TETER, JR. (WILLIAMSBURG, Virginia);  DAVID A. PADDOCK (TOANO, Virginia);  I.O.K. M. WONG (HAMPTON, Virginia);  ROUNAK MIKHOPADHYAY (BRIDGEWATER, New Jersey);  ROBERT F. MARTIN (HAMPTON, Virginia);  PATRICK A. COSGROVE (HAMPTON, Virginia);  DAMON E. SHEAFFER (HAMPTON, Virginia);  B.DANETTE ALLEN (NORFOLK, Virginia);  WALTER J. WALTZ (WILLIAMSBURG, Virginia);  RALPH A. WILLIAMS (HAMPTON, Virginia);  SHERIF A. SHAZLY (HAMPTON, Virginia);  JOHN R. COOPER (YORKTOWN, Virginia);  MATTHEW P. VAUGHAN (HAMPTON, Virginia);  JAMES V. PLANT (NORFOLK, Virginia)
ABSTRACT The present disclosure describes systems and methods for mapping a planar surface to a curved surface. One such method comprises providing a planar lattice pattern having identical regular polygon shapes which can be truss support modules for supporting a curved surface structure. Method further include determining respective positions of the nodal points of the identical polygon shapes by placing a starting nodal point on an axis of symmetry of the planar lattice pattern and iteratively positioning each nodal point in relation to already placed neighboring nodes to make a distance between a currently positioned nodal point optimally close with a set value of the planar lattice pattern. Method still further comprises forming a curved lattice pattern of the truss support module based on the positions of the nodal points of the identical polygon shapes.
FILED Tuesday, September 28, 2021
APPL NO 17/487598
CURRENT CPC
Electric Digital Data Processing
G06F 30/13 (20200101)
G06F 30/23 (20200101) Original (OR) Class
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United States Postal Service (USPS) 

US 20220095822 Tartal et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) William Albert Tartal (Baltimore, Maryland);  Joram Shenhar (Fairfax, Virginia);  Joel Locknauth Dewnandan (Bladensburg, Maryland)
ABSTRACT A lockout device for an opening of a collection box, such as a postal collection box. The lockout device can include a cover sized to block the opening to prevent access to the contents of the collection box through the opening. In one example, the cover can be assembled over the opening and a locking pin can be inserted through apertures in the lateral sides of the opening walls and lateral sides of the cover. The locking pin can be lock in place using a lock and lock guard. In another example, the cover includes an internal extension assembly with clamping mechanisms that can engage with the lateral sides of the opening.
FILED Wednesday, September 29, 2021
APPL NO 17/449422
CURRENT CPC
Household or Table Equipment
A47G 29/126 (20130101) Original (OR) Class
A47G 29/1207 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220100980 Simpson
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan J. Simpson (Vienna, Virginia)
ABSTRACT The present disclosure relates to a system and method for extracting a region of interest from a captured image of an item. The system may include a reader configured to capture an image of an item having a computer readable code positioned thereon. The system may also include a processor in data communication with the reader and configured to generate captured image data, the captured data comprising binary image data and identify a first pixel region representing the computer readable code from the binarized image data. The processor may be further configured to remove a second pixel region other than the first pixel region from the binarized image data and store or process only first binarized image data representing the first pixel region.
FILED Monday, September 27, 2021
APPL NO 17/449039
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 7/1413 (20130101) Original (OR) Class
G06K 7/1417 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/13 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220101259 Simpson
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan J. Simpson (Vienna, Virginia)
ABSTRACT The present disclosure relates to a system and method for improving scan rates of an item in a distribution network. The system may include an item scan database storing item scan datasets containing barcodes, item datasets and optical character recognition (OCR) labels datasets and a processor in data communication with the item scan database. The processor may detect an item barcode with an item orien