FedInvent™ Patent Applications
Application Details for Thursday, July 07, 2022
This page was updated on Thursday, July 07, 2022 at 01:57 PM GMT
Department of Health and Human Services (HHS)
| US 20220211017 | Newman et al. |
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| FUNDED BY |
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| APPLICANT(S) | VERSITI BLOOD RESEARCH INSTITUTE FOUNDATION, INC. (MILWAUKEE, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter J. Newman (Bayside, Wisconsin); Huiying Zhi (Brookfield, Wisconsin) |
| ABSTRACT | A transgenic mouse comprising T30A, S32P, Q33L, N39D, and M470Q mutations in GPIIIa, as well as methods for making the transgenic mouse and methods for using the transgenic mouse to screen test compounds are described. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668086 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2217/07 (20130101) A01K 2227/105 (20130101) A01K 2267/0387 (20130101) Peptides C07K 14/70546 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/89 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/5047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211312 | Brinkmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Benjamin H. Brinkmann (Byron, Minnesota); Squire Matthew Stead (Bozeman, Montana); Gregory Worrell (Rochester, Minnesota) |
| ABSTRACT | Multiscale brain electrodes can be used for spatiotemporal mapping, probing, and therapeutic modulation of the human brain. The applications for such functional mapping and electrical stimulation modulation span, for example, neurological and psychiatric diseases, and brain rehabilitation. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544782 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/055 (20130101) A61B 5/291 (20210101) Original (OR) Class A61B 5/4064 (20130101) A61B 5/4094 (20130101) A61B 5/6868 (20130101) A61B 5/7264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211334 | Furenlid et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lars Furenlid (Tucson, Arizona); Xin Li (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Lars Furenlid (Tucson, Arizona); Xin Li (Tucson, Arizona) |
| ABSTRACT | A scintillation-crystal based gamma-ray detector with photon sensors disposed on edge surface(s) of the crystal to take advantage of total internal reflection of scintillation photons within the thin-slab detector substrate to improve spatial resolution of determination of a scintillation event (including depth-of-interaction resolution) while preserving energy resolution and detection efficiency. The proposed structure benefits from the reduced—as compared with related art—total number of readout channels elimination of need in complicated and repetitive cutting and polishing operations to form pixelated crystal arrays used in conventional PET detector modules. Detectors systems utilizing stacks of such detectors, and methods of operation of same. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700442 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Original (OR) Class A61B 6/4258 (20130101) Measurement of Nuclear or X-radiation G01T 1/202 (20130101) G01T 1/20181 (20200501) G01T 1/20185 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211350 | Pinton et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gianmarco Francesco Pinton (Chapel Hill, North Carolina); Thomas Montgomery Keirski (Durham, North Carolina); David Antonio Espindola Rojas (Chapel Hill, North Carolina); Paul Alexander Dayton (Carrboro, North Carolina); Isabel Grace Newsome (Chapel Hill, North Carolina) |
| ABSTRACT | A method for producing an image of at least one vessel with ultrasound includes administering a contrast agent particle into the at least one vessel, and delivering an ultrasound pulse having a first frequency range to the at least one vessel. The method further includes detecting ultrasound energy scattered from the contrast agent particle at a second frequency range that is different from the first frequency range, converting the scattered ultrasound energy into an electronic radio frequency signal, and using an algorithm to determine a spatial location of the contrast agent particle based on extraction of a specific feature of the radio frequency signal. The method further includes generating an image by displaying a marker of the spatial location of the contrast agent particle with a resolution that is finer than a pulse length of the ultrasound pulse and repeating the detecting, converting, using, and generating for a plurality of contrast agent particles until sufficient markers have been accumulated to reconstruct a pattern of the at least one vessel; wherein the pattern is an image of the at least one vessel. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/606986 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/0891 (20130101) A61B 8/5207 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211351 | Torres et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | William M. Torres (Philadelphia, Pennsylvania); Francis G. Spinale (Blythewood, South Carolina); Tarek M. Shazly (Columbia, South Carolina) |
| ABSTRACT | Methods and systems for utilizing myocardial strain imaging in an inverse framework to identify mechanical properties of the heart and to determine structural and functional milestones for the development and progression to heart failure. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702067 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/485 (20130101) A61B 8/0883 (20130101) A61B 8/5223 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 17/20 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211543 | Mikula et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Mikula (Rancho Santa Margarita, California); James V. Jester (Irvine, California); Tibor Juhasz (Corona del Mar, California); Samantha Bradford (Irvine, California) |
| ABSTRACT | A system for creating micro-channels through superficial corneal epithelium, the system including: a femtosecond laser having a pulse energy range of 1 to 20 microjoules (μJ) and a capability of generating a laser beam having a wavelength of 700-1100 nanometers (nm) and a repetition rate of 1 kilohertz to 1 megahertz, a laser delivery system comprising a beam expander, a scanning lens having a numerical aperture (NA) of 0.05 to 0.5 and a focusing objective, and control software that controls the delivery system such that the laser beam is scanned in a pattern. The system is used to noninvasively increase corneal epithelial permeability to therapeutic agents through micron-scale channels created through the corneal epithelium by the system or to induce wound healing in a cornea in a subject following creation of micron-scale channels in the cornea. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/603830 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2018/00702 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0008 (20130101) A61F 9/0084 (20130101) Original (OR) Class A61F 2009/00872 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211622 | Thaxton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | C. Shad Thaxton (Chicago, Illinois); Chad A. Mirkin (Wilmette, Illinois); Kaylin M. McMahon (Chicago, Illinois); Sushant Tripathy (Evanston, Illinois); Raja Kannan Mutharasan (Chicago, Illinois); David M. Leander (St. Louis, Missouri); Andrea Luthi (Evanston, Illinois) |
| ABSTRACT | Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703824 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 9/1271 (20130101) A61K 9/5115 (20130101) A61K 9/5123 (20130101) A61K 31/7088 (20130101) A61K 47/544 (20170801) A61K 47/554 (20170801) A61K 47/6917 (20170801) A61K 47/6923 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) C12N 15/111 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211633 | Thaxton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | C. Shad Thaxton (Chicago, Illinois); Robert M. Lavker (Evanston, Illinois); Kaylin M. McMahon (Chicago, Illinois); Han Peng (Evanston, Illinois); Andrea E. Calvert (Chicago, Illinois); Nihal Kaplan (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are nanostructures, compositions, and methods for treating ocular disorders, injuries, and infections using RNA complexed nanoparticles (e.g., RNA-templated lipoprotein particles, miRNA-high density lipoprotein particles). These nanostructures are contemplated in topical therapies. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1617 (20130101) A61K 9/5115 (20130101) A61K 9/5123 (20130101) Original (OR) Class A61K 31/713 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211634 | Labhasetwar |
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| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinod Labhasetwar (Solon, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and/or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 38/446 (20130101) A61K 38/482 (20130101) Enzymes C12Y 108/01007 (20130101) C12Y 111/01006 (20130101) C12Y 111/01009 (20130101) C12Y 115/01001 (20130101) C12Y 304/21068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211652 | Sanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | Io Therapeutics, Inc (Spring, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin E. Sanders (Spring, Texas); Powel H. Brown (Houston, Texas) |
| ABSTRACT | The present specification provides combinations of active agents for the improved treatment of Her2+ cancers and associated methods of treatments. The combinations comprise and RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/553612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/185 (20130101) A61K 31/216 (20130101) Original (OR) Class A61K 31/517 (20130101) A61K 31/4709 (20130101) A61K 38/24 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211658 | Fu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Zhanyan Fu (Cambridge, Massachusetts); Jennifer Q. Pan (Cambridge, Massachusetts); Ayan Ghoshal (Cambridge, Massachusetts); Guoping Feng (Cambridge, Massachusetts); Edward Scolnick (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods for treating a disorder associated with a sleep spindle deficit using a group II metabotropic glutamate receptor modulator. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/610130 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) Original (OR) Class A61K 31/381 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211663 | Huang et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leaf Huang (Chapel Hill, North Carolina); Jing Zhang (Chapel Hill, North Carolina); Limei Shen (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed are micellar formulations comprising a synergistic combination of quercetin and alantolactone and their use for treating a cancer, including microsatellite-stable colorectal cancer (CRC), which otherwise is resistant to immunotherapy. The combination of quercetin and alantolactone was found to induce synergistic immunogenic cell death (ICD) at synergistic ratiometric micellar loadings. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/22 (20130101) A61K 47/24 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211669 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Jianjun Chen (Cincinnati, Ohio); Xi Jiang (Cincinnati, Ohio) |
| ABSTRACT | A method of treating a subject suffering from a condition characterized by over-expression of Ten-eleven translocation 1 (TET1) is provided, the method including administering to the subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the Formula I: wherein: R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, hydroxyl, alkyl, alkoxy, amine, halo, and trifluoromethyl, and wherein any two adjacent moieties of R1, R2, R3, R4, and R5 may come together to form a heterocyclic ring; R6 is H or hydroxyl; and R7 is selected from H, wherein R8 is C or O. Also provided are methods for selectively suppressing transcription of TET1 and/or reducing a level of 5-hydroxymethylcytosine in a subject by administering an effective amount of a Formula I compound and pharmaceutical compositions comprising Formula I compounds. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/365 (20130101) A61K 31/4025 (20130101) Original (OR) Class A61K 31/4525 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211683 | WU et al. |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Xiaoyang WU (Chicago, Illinois); Jian ZHANG (Chicago, Illinois) |
| ABSTRACT | Methods and compositions for preventing or inhibiting the formation of scars are disclosed. The methods and compositions include a TGF-β inhibitor provided in a delayed release composition. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/595098 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/5031 (20130101) A61K 31/4439 (20130101) Original (OR) Class A61K 41/00 (20130101) A61K 47/10 (20130101) A61K 47/32 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/54 (20130101) A61L 27/60 (20130101) A61L 2300/414 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211690 | Parsons et al. |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
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| INVENTOR(S) | Ramon Parsons (Manhasset, New York); Deepti Mathur (Colombus, Ohio); Ilias Stratikopoulos (New York, New York) |
| ABSTRACT | Methods for assessing the efficacy of dihydroorotate dehydrogenase inhibitors in the treatment of cancer and methods of using such inhibitors to treat PTEN-mutant cancer are provided. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/476353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/47 (20130101) Original (OR) Class A61K 31/277 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 2800/52 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211695 | XING et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HAO XING (Atlanta, Georgia); CHUN JIANG (Atlanta, Georgia); NATHAN N. SABATE (Atlanta, Georgia); CHRISTOPHER M. JOHNSON (Atlanta, Georgia) |
| ABSTRACT | Disclosed is a method for reducing opioid-induced breathing, phrenic and rVRG abnormal activities. The disclosed methods can maintain the desired effects of an opioid while reducing any unwanted breathing problems. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/612152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) Original (OR) Class A61K 31/4453 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211700 | Niculescu |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Bloomington, Indiana); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211702 | Miller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan D. Miller (Rochester, Minnesota); Maurice E. Enriquez-Sarano (Rochester, Minnesota); Bin Zhang (Rochester, Minnesota); Carolyn Marie Roos (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 31/635 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) A61P 9/10 (20180101) A61P 9/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211706 | Habib |
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| FUNDED BY |
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| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/277 (20130101) A61K 31/416 (20130101) A61K 31/454 (20130101) A61K 31/498 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 31/713 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/4985 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/241 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211710 | Radu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caius Gabriel Radu (Los Angeles, California); Evan Robert Abt (Santa Monica, California); Thuc Minh Le (Los Angeles, California) |
| ABSTRACT | The present invention relates to methods of selecting a subject with cancer for treatment, screening a test molecule for use as a cancer therapeutic, and treating a subject with cancer, as well as compositions for treating cancer. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 17/631299 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 31/708 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211714 | Gendelman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard E. Gendelman (Omaha, Nebraska); Xin-Ming Liu (Omaha, Nebraska); Benson Edagwa (Omaha, Nebraska) |
| ABSTRACT | The present invention provides compositions and methods for the delivery of antivirals to a cell or subject. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/655112 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5146 (20130101) A61K 31/52 (20130101) Original (OR) Class A61K 31/513 (20130101) A61K 47/64 (20170801) A61K 47/542 (20170801) A61K 47/551 (20170801) A61K 47/6901 (20170801) A61K 47/6907 (20170801) A61K 47/6921 (20170801) A61K 47/6929 (20170801) Heterocyclic Compounds C07D 411/04 (20130101) C07D 473/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211716 | Gendelman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard Gendelman (Omaha, Nebraska); Benson Edagwa (Omaha, Nebraska) |
| ABSTRACT | The present invention provides prodrugs and methods of use thereof. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655483 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1641 (20130101) A61K 31/519 (20130101) A61K 31/5365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211738 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Jill P. Smith (Washington, District of Columbia); Stephan Stern (Frederick, Maryland); Abdullah Mahmud (Frederick, Maryland) |
| ABSTRACT | A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/555285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 9/1075 (20130101) A61K 9/5146 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 47/10 (20130101) A61K 47/60 (20170801) A61K 47/183 (20130101) A61K 47/6455 (20170801) A61K 47/6935 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/115 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2310/351 (20130101) C12N 2320/30 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211742 | Ro |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEVADA RESEARCH and INNOVATION CORPORATION (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seungil Ro (Reno, Nevada) |
| ABSTRACT | The present invention relates to methods and compositions comprising a miR-10a-5p or miR-10b-5p mimic for treatment of gastrointestinal motility disorders, obesity and diabetes. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/605958 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 31/7105 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211755 | Freytes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald O. Freytes (Summit, New Jersey); Gordana Vunjak-Novakovic (New York, New York); John O'Neill (New York, New York) |
| ABSTRACT | Region-specific extracellular matrix (ECM) biomaterials are provided. Such materials include acellular scaffolds, sponges, solutions, and hydrogels suitable for stem cell culture. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696321 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Original (OR) Class A61K 35/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 5/0686 (20130101) C12N 5/0687 (20130101) C12N 2533/52 (20130101) C12N 2533/54 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211759 | WHERRY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | E. John WHERRY (Havertown, Pennsylvania); Omar KHAN (San Francisco, California); Josephine GILES (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides methods of preventing, reducing or reversing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell, and uses thereof. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607612 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211785 | DENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Liang DENG (New York, New York); Jedd WOLCHOK (New York, New York); Taha MERGHOUB (New York, New York); Stewart SHUMAN (New York, New York); Peihong DAI (New York, New York); Weiyi WANG (New York, New York) |
| ABSTRACT | The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAΔE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575462 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 39/12 (20130101) A61K 39/3955 (20130101) A61K 2039/54 (20130101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211796 | KUMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishna KUMAR (Medford, Massachusetts); Emel ADALIGIL (Medford, Massachusetts) |
| ABSTRACT | The invention features peptide antibiotic compositions and methods of using such compositions for the treatment of bacterial infections (e.g., vancomycin resistant infections). |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611720 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211811 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | T.C. Wu (Stevenson, Maryland); Chien-Fu Hung (Timonium, Maryland); Brandon Lam (Baltimore, Maryland) |
| ABSTRACT | The present invention provides a novel fusion protein of Flt3L and albumin and its use to increase the Flt3L half-life in vivo and to deliver Flt3L to immune cells in a subject to enhance alternative dendritic cell populations. Use of the fusion protein in combination with other chemotherapeutic, radiotherapeutic and immunotherapeutic methods are also provided. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) A61K 38/19 (20130101) A61K 38/38 (20130101) A61K 38/1793 (20130101) Original (OR) Class A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/475 (20130101) C07K 14/765 (20130101) C07K 16/2827 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211814 | GUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Zong Sheng GUO (Wexford, Pennsylvania); Binfeng LU (Pittsburgh, Pennsylvania); David L. BARTLETT (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure provides interleukin-36 (IL-36) cytokine (e.g., IL-36γ) expressing oncolytic viruses, and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/696978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/17 (20130101) A61K 35/742 (20130101) A61K 35/768 (20130101) A61K 38/20 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211820 | Pearlman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Pearlman (Cleveland, Ohio); Sixto M. Leal, JR. (Cleveland, Ohio) |
| ABSTRACT | A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/583498 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0014 (20130101) A61K 9/0048 (20130101) A61K 31/16 (20130101) A61K 31/22 (20130101) A61K 31/40 (20130101) A61K 31/69 (20130101) A61K 31/198 (20130101) A61K 31/366 (20130101) A61K 31/426 (20130101) A61K 31/4196 (20130101) A61K 31/4412 (20130101) A61K 38/16 (20130101) A61K 38/40 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211822 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Xiaoyang WU (Chicago, Illinois); Jian ZHANG (Chicago, Illinois) |
| ABSTRACT | Compositions and methods are provided concerning a lactate-responsive drug release system. In some embodiments, there are methods and compositions for treating cancer that take advantage of the tumor environment to deliver therapeutic agents to the tumor while reducing problems associated with circulating drugs in the patients body. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/595326 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 38/47 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 47/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211824 | ANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | David K. ANN (Arcadia, California); Yun-Ru CHEN (Duarte, California); Fuming QIU (Duarte, California) |
| ABSTRACT | Autophagy is the principal catabolic response to nutrient starvation. However, excessive autophagy can be cytotoxic or cytostatic, and contribute to cell death, but its mechanism of induction remains elusive. Here, it was demonstrated that prolonged arginine starvation by ADI-PEG20 induced an autophagy-dependent death of argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Consequently, arginine depleting agents such as ADI-PEG20 may be used in methods for killing one or more argininosuccinate synthetase 1 (ASS1)-deficient breast cancer cells. Further, abundance of ASS1 was either low or absent in more than 60% of 149 random breast cancer biosam pies, which could be exploited as candidates for arginine starvation therapy. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/580241 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 38/50 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/60 (20170801) Enzymes C12Y 305/03006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211828 | Hunt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| INVENTOR(S) | Donald F. Hunt (Charlottesville, Virginia); Jeffrey Shabanowitz (Charlottesville, Virginia); Jennifer G. Abelin (Boston, Massachusetts); William H. Hildebrand (Edmond, Oklahoma); Andrea M. Patterson (Indianapolis, Indiana) |
| ABSTRACT | A set of target peptides are presented by HLA A*0201 on the surface of ovarian cancer cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., ovarian cancer, (b) function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/00111 (20180801) A61K 39/00119 (20180801) A61K 39/001106 (20180801) A61K 39/001118 (20180801) A61K 39/001132 (20180801) A61K 39/001151 (20180801) A61K 39/001156 (20180801) A61K 39/001157 (20180801) A61K 39/001162 (20180801) A61K 39/001164 (20180801) A61K 39/001166 (20180801) A61K 39/001181 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001189 (20180801) A61K 39/001192 (20180801) A61K 39/001193 (20180801) A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 39/001197 (20180801) A61K 45/06 (20130101) A61K 47/6849 (20170801) A61K 2039/515 (20130101) A61K 2039/572 (20130101) A61K 2039/5154 (20130101) A61K 2039/5158 (20130101) Peptides C07K 9/001 (20130101) C07K 16/2833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211848 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth C. Anderson (Wellesley, Massachusetts); Annamaria Gullà (Boston, Massachusetts) |
| ABSTRACT | The present invention relates, in part, to methods of inducing immunogenic cell death to treat a cancer in a subject comprising administering to the subject a therapeutically effective amount of an agent that increases one or more biomarkers listed in Table 1 in combination with an inducer of immunogenic cell death (ICD). |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211858 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Honggang Cui (Lutherville, Maryland); Hao Su (Baltimore, Maryland); Feihu Wang (Baltimore, Maryland) |
| ABSTRACT | The present invention provides the design of a class of prodrugs for self-assembly into therapeutic tubular supramolecular polymers and their use in a wide variety of applications. The therapeutic tubular supramolecular polymers can be used to formulate drugs and imaging agents for in vitro and in vivo uses. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/604661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/4745 (20130101) A61K 47/60 (20170801) A61K 47/645 (20170801) Original (OR) Class A61K 47/6903 (20170801) A61K 47/6907 (20170801) A61K 47/6949 (20170801) A61K 49/0021 (20130101) A61K 49/0039 (20130101) A61K 49/0095 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211875 | McIvor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); HealthPartners Institute f/k/a HealthPartners Research Foundation (Bloomington, Minnesota); Regenxbio Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Scott McIvor (St. Louis Park, Minnesota); Lalitha R. Belur (St. Paul, Minnesota); Karen Kozarsky (Bala Cynwyd, Pennsylvania); William H. Frey, II (White Bear Lake, Minnesota) |
| ABSTRACT | A method to prevent, inhibit or treat one or more symptoms associated with disease of the central nervous system by intranasally, intrathecally, intracerebrovascularly or intravenously administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease, in an amount effective, e.g., to provide for cross-correction. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/675 (20130101) A61K 38/47 (20130101) A61K 45/06 (20130101) A61K 48/0075 (20130101) Original (OR) Class A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) Enzymes C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211878 | Yantasee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Jingga Morry (Portland, Oregon); David Castro (Portland, Oregon); Joe William Gray (Lake Oswego, Oregon) |
| ABSTRACT | Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/16 (20130101) A61K 47/59 (20170801) A61K 47/60 (20170801) A61K 47/551 (20170801) A61K 47/6849 (20170801) A61K 47/6855 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) A61K 49/0093 (20130101) Original (OR) Class A61K 49/186 (20130101) A61K 49/1857 (20130101) A61K 49/1875 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211880 | Jasanoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Alan Pradip Jasanoff (Cambridge, Massachusetts); Jacob Simon (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides imaging and contrast agents, and methods of using the agents. According to some embodiments of the disclosure, agents and methods for magnetic resonance imaging and related technologies are provided. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/24 (20130101) A61K 47/28 (20130101) A61K 49/108 (20130101) A61K 49/1812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211881 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Michael Bruckman (Cleveland, Ohio); Lauren Randolph (State College, Pennsylvania) |
| ABSTRACT | An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/108 (20130101) A61K 49/1896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211967 | Hall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Gregory W. Hall (Belmont, Massachusetts); Kevin Cedrone (Boxborough, Massachusetts); Philip E. Silkoff (Boulder, Colorado); Wolfgang Scholz (Beverly, Massachusetts) |
| ABSTRACT | Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/04 (20130101) A61M 16/12 (20130101) Original (OR) Class A61M 16/022 (20170801) A61M 16/024 (20170801) A61M 16/0057 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/107 (20140204) A61M 16/202 (20140204) A61M 16/0666 (20130101) A61M 2202/0275 (20130101) A61M 2202/0283 (20130101) A61M 2205/05 (20130101) A61M 2205/054 (20130101) A61M 2205/80 (20130101) A61M 2205/125 (20130101) A61M 2205/502 (20130101) A61M 2205/3584 (20130101) A61M 2205/8206 (20130101) A61M 2209/088 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212036 | Naqa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Issam El Naqa (Ann Arbor, Michigan); Xueding Wang (Ann Arbor, Michigan); Paul Carson (Ann Arbor, Michigan); Kyle Cuneo (Ann Arbor, Michigan); Jean Moran (Ann Arbor, Michigan); Wei Zhang (Ann Arbor, Michigan); Ibrahim Oraiqat (Ann Arbor, Michigan) |
| ABSTRACT | A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/600564 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/485 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1038 (20130101) A61N 5/1039 (20130101) A61N 5/1049 (20130101) A61N 5/1067 (20130101) Original (OR) Class A61N 5/1071 (20130101) A61N 2005/1054 (20130101) A61N 2005/1058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212188 | Chaput et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| INVENTOR(S) | John Chaput (Irvine, California); Derek Vallejo (Los Angeles, California); Brian Paegel (Irvine, California) |
| ABSTRACT | Systems and method for sorting droplets includes a microfluidic chip or substrate having a droplet sorting channel coupled at an upstream location to a droplet inlet channel, the droplet sorting channel coupled at a downstream location to a waste channel and a collection channel. The device includes an optical interrogation device configured to illuminate the droplets passing through the sorting channel with excitation light from an excitation light source and capturing emitted fluorescent light and generating an output signal correlated to the fluorescence of the droplets. An actuator (electrode) is disposed in the microfluidic chip or substrate and coupled to a signal driver (e.g., a high voltage amplifier). The device or system uses a programmable controller configured to receive the output signals from the optical interrogation device and trigger the signal driver to actuate the actuator to direct the droplets into the collection channel. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607008 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502753 (20130101) B01L 3/502784 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1459 (20130101) G01N 15/1484 (20130101) G01N 2015/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213036 | BATCHELOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NovaTarg, Inc. (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth BATCHELOR (Wilmington, North Carolina); Jeffery E. COBB (Chapel Hill, North Carolina); Kristjan S. GUDMUNDSSON (Raleigh, North Carolina); Brad R. HENKE (Cary, North Carolina); Francis X. Tavares (Durham, North Carolina) |
| ABSTRACT | The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5′ adenosine monophosphate-activated protein kinase (AMPK). |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/578050 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Heterocyclic Compounds C07D 209/20 (20130101) Original (OR) Class C07D 209/32 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213052 | Aube et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Jeff Aube (Chapel Hill, North Carolina); Sudeshna Roy (Lawrence, Kansas); Liang XU (Lawrence, Kansas); Xiaoqing WU (Lawrence, Kansas); Lan LAN (Lawrence, Kansas) |
| ABSTRACT | The present technology is directed to compounds that inhibit of the interaction of RNA-binding proteins with RNA, intermediates thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I). |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607003 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/42 (20130101) C07D 333/60 (20130101) Original (OR) Class C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213054 | WHITEHEAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mekanistic Therapeutics LLC (Ann Arbor, Michigan) |
| ASSIGNEE(S) | Mekanistic Therapeutics LLC (Ann Arbor, Michigan) |
| INVENTOR(S) | Christopher E. WHITEHEAD (Ann Arbor, Michigan); Judith S. LEOPOLD (Ann Arbor, Michigan) |
| ABSTRACT | This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof, wherein the variables Ring A, X, R1a, R1b, R2, R3, R4, m, n, and p are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The disclosure further relates to the use of the compounds described herein as therapeutics for the treatment of diseases and conditions mediated by EGFR proteins and/or PI3K proteins, such as cancer and other diseases. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558399 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213068 | Haskell-Luevano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (Port St. Lucie, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Haskell-Luevano (Minneapolis, Minnesota); Skye Ross Doering (Minneapolis, Minnesota); Marcello A. Giulianotti (Port St. Lucie, Florida); Clemencia Pinilla (Port St. Lucie, Florida); Radleigh G. Santos (Port St. Lucie, Florida); Richard A. Houghten (Port St. Lucie, Florida) |
| ABSTRACT | The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567201 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/485 (20130101) A61K 9/2013 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4858 (20130101) A61K 9/4866 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Heterocyclic Compounds C07D 403/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213081 | Stoltz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian M. Stoltz (San Marino, California); Alexander W. Sun (Irvine, California); Stephan N. Hess (Pasadena, California); Carina I. Jette (Pasadena, California); Irina Geibel (Bad Zwischenahn, Germany); Shoshana Bachman (Las Vegas, Nevada); Masaki Hayashi (Kanagawa, Japan); Hideki Shimizu (Hyogo, Japan); Jeremy B. Morgan (Wilmington, North Carolina); Shunya Sakurai (Kyoto, Japan); Zachary P. Sercel (Pasadena, California) |
| ABSTRACT | Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee). |
| FILED | Friday, December 31, 2021 |
| APPL NO | 17/566915 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/26 (20130101) C07D 239/06 (20130101) C07D 241/08 (20130101) C07D 243/08 (20130101) C07D 413/14 (20130101) Original (OR) Class C07D 507/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213087 | Ye |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| INVENTOR(S) | Keqiang Ye (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to asparagine endopeptidase inhibitors and compositions and uses related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are useful for improving memory, treating or preventing cancer, neurodegenerative diseases, and cognitive disorders. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613225 |
| CURRENT CPC | Heterocyclic Compounds C07D 271/12 (20130101) C07D 417/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213094 | STARCZYNOWSKI et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel T. STARCZYNOWSKI (Cincinnati, Ohio); Craig J. THOMAS (Gaithersburg, Maryland); Garrett RHYASEN (Burlington, Massachusetts); Katelyn MELGAR (Cincinnati, Ohio); Morgan MacKenzie WALKER (New Haven, Connecticut); Jian-Kang JIANG (Columbia, Maryland) |
| ABSTRACT | Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)). Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer or blood disorders). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568023 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213146 | Walensky et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Brookline, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loren D. Walensky (Newton, Massachusetts); Gregory H. Bird (Pelham, New Hampshire) |
| ABSTRACT | Provided herein is a platform technology for designing stabilized peptides that covalently bind their target protein and thereby inhibit the activity of the target protein. Also provided are exemplary stabilized peptides that can be used for covalent modification of their target proteins. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389761 |
| CURRENT CPC | Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/001 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/6803 (20130101) G01N 33/6845 (20130101) G01N 2030/8831 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213153 | HSIA et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang HSIA (Seattle, Washington); Rubul MOUT (Seattle, Washington); Natasha EDMAN (Seattle, Washington); Ivan VULOVIC (Seattle, Washington); Una NATTERMANN (Seattle, Washington); William H. SHEFFLER (Seattle, Washington); TJ BRUNETTE (Seattle, Washington); Young-Jun PARK (Seattle, Washington); Asim BERA (Seattle, Washington); Matthew BICK (Seattle, Washington); Rachel REDLER (Seattle, Washington); Damian EKIERT (Seattle, Washington); Gira BHABHA (Seattle, Washington); David VEESLER (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213165 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Chun LI (Houston, Texas); Chiyi XIONG (Houston, Texas); Yunfei WEN (Houston, Texas); Anil SOOD (Houston, Texas) |
| ABSTRACT | Provided herein are therapeutic peptides. In some aspects, therapeutic peptides are provided that can alter EphB4/EFNB2 signaling and can be used to treat a cancer. In some embodiments, the peptides are comprised in nanoparticles, such as core-cross-linked polymeric micelles (CCPM). |
| FILED | Friday, May 08, 2020 |
| APPL NO | 17/609536 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 47/6415 (20170801) A61K 47/6425 (20170801) A61K 47/6909 (20170801) A61K 49/0082 (20130101) A61K 51/1227 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213193 | ELIAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack A. ELIAS (Providence, Rhode Island); Chun Geun LEE (Providence, Connecticut); Suchitra KAMLE (Providence, Rhode Island) |
| ABSTRACT | Described herein are bispecific antibodies simultaneously targeting both CHI3L1 and the immune checkpoint molecule PD-1. These antibodies manifest enhanced synergistic cytotoxic effects compared to the effects of individual CHI3L1 and PD-1 antibodies, alone or in combination. Methods of treating a cancer by administering the bispecific antibodies described herein are also provided. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/609309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213214 | VERMEER |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paola VERMEER (Sioux Falls, South Dakota) |
| ABSTRACT | Disclosed herein are isolated anti-human ephrin B1 antibodies, or fragments thereof, and methods for their use in treating tumors. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/606847 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213219 | CONKLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas S. CONKLIN (Niskayuna, New York); Cheryl EIFERT (Roslindale, Massachusetts); Antonis KOURTIPIS (Jacksonville, Florida); Leila KOKABEE (Albany, New York); Xiauhui WANG (Albany, New York) |
| ABSTRACT | Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over 5 half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 10 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) C07K 16/40 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 207/10001 (20130101) C12Y 207/10002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/57415 (20130101) G01N 2333/9121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213252 | Langer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Biocant-Center of Innovation and Biotechnology (Cantanhede, Portugal) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Jeffrey M. Karp (Chestnut Hill, Massachusetts); Maria Jose Maio Nunes-Pereira (Lisbon, Portugal); Ben Ouyang (Toronto, Canada); Lino da Silva Ferreira (Coimbra, Portugal); Debanjan Sarkar (Williamsville, New York) |
| ABSTRACT | Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/703 (20130101) A61K 9/7084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/14 (20130101) C08G 18/4236 (20130101) Original (OR) Class C08G 18/4238 (20130101) C08G 18/4283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213433 | BAACK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SANFORD HEALTH (Sioux Falls, South Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle BAACK (Sioux Falls, South Dakota); Pilar DE LA PUENTE (Sioux Falls, South Dakota); Tyler GANDY (Sioux Falls, South Dakota) |
| ABSTRACT | The disclosure provides three-dimensional cross-linked scaffolds generated from cord blood plasma, and methods for making and using such scaffolds. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 17/612147 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0068 (20130101) Original (OR) Class C12N 5/0605 (20130101) C12N 2500/14 (20130101) C12N 2500/33 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) C12N 2535/00 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213440 | DECKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William K. DECKER (Houston, Texas); Matthew HALPERT (Houston, Texas) |
| ABSTRACT | Methods of providing a targeted immune response in a subject comprising administration of a dendritic cell population are provided. In some aspects, dendritic cells are administered in conjunction with a Type I interferon (INF), a TLR-7 agonist, a TLR-9 agonist, AIMp1, a TLR-3 agonist, a retinoic acid inducible gene-1 (RIG-1)-like receptor ligand or a cytosolic DNA (CDS) receptor ligand and/or are administered to a tissue site proximal to diseased tissue. Therapeutic dendritic cell compositions are likewise provided. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/708 (20130101) A61K 31/713 (20130101) A61K 31/4745 (20130101) A61K 35/17 (20130101) A61K 38/21 (20130101) A61K 38/212 (20130101) A61K 38/1709 (20130101) A61K 39/0011 (20130101) A61K 45/06 (20130101) A61K 2039/5154 (20130101) A61K 2039/55522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213452 | Taunton et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John W. Taunton (San Francisco, California); Wendell A. Lim (San Francisco, California); Chia-Yung Wu (San Francisco, California) |
| ABSTRACT | The present disclosure provides conditionally active, heterodimeric polypeptides. The conditionally active, heterodimeric polypeptides are active in the presence of a dimerizing agent that induces dimerization of the polypeptides of the heterodimer. A conditionally active, heterodimeric polypeptide of the present disclosure is useful in a variety of research and treatment methods, which are also provided. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/412047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 1/36 (20130101) C07K 2/00 (20130101) C07K 14/72 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213459 | Rajan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rakhi Rajan (Norman, Oklahoma) |
| ABSTRACT | Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704317 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/74 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213460 | Griswold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karl E. Griswold (Lyme, New Hampshire); Hongliang Zhao (Hanover, New Hampshire) |
| ABSTRACT | Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480166 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class Enzymes C12Y 304/24075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213462 | Bouhassira et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Eric Bouhassira (Hastings On Hudson, New York); Khulan Batbayar (Pelham, New York); Karl Roberts (Brooklyn, New York) |
| ABSTRACT | This disclosure provides methods and compositions for treating TTP based on transfusion of a relatively small number of genetically modified red blood cells. The genetically modified red blood cells express a fusion protein including a fragment of ADAMTS13 that is enzymatically active against von Willebrand factor (VWF). The fragments of ADAMTS13 can be resistant to the inhibitors, e.g., the auto-immune antibodies, which are responsible for the acquired form of TTP. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/605864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/18 (20130101) A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Peptides C07K 14/745 (20130101) C07K 2319/035 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) C12N 9/6489 (20130101) Original (OR) Class C12N 2506/45 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 304/24087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213468 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Qianru LI (Evanston, Illinois); Haiwang YANG (Evanston, Illinois); Zhe JI (Evanston, Illinois) |
| ABSTRACT | A low-input RNase footprinting approach is described for the rapid quantification of ribosome-protected fragments with 1,000-100,000 cells. The assay uses a simplified procedure for capturing ribosome-RNA complexes based on optimized RNase digestion. It simultaneously maps cytosolic and mitochondrial translation with single-nucleotide resolution. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543476 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 15/1096 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 301/27008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213469 | Blainey et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Blainey (Cambridge, Massachusetts); Jacob Borrajo (Cambridge, Massachusetts) |
| ABSTRACT | Method of generating a barcoded library, comprising delivering a polynucleotide into a cell, each polynucleotide comprising: (i) a sequence encoding a barcoding construct operably linked to a first promoter that is an antisense promoter, wherein the barcoding construct comprises a trans-splicing element and a barcode sequence; and a sequence encoding a perturbation element operably linked to a second promoter; generating RNA transcripts of the polynucleotide delivered into the cell, wherein the RNA transcripts comprise the barcoding construct and the perturbation element; and splicing the barcoding sequence onto endogenous RNA molecules in the cell, thereby generating a barcoded library, each member of the barcoded library comprising the barcode sequence and the endogenous RNA molecule attached with the barcode sequence. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/607615 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/1241 (20130101) C12N 2740/15043 (20130101) C12N 2830/008 (20130101) C12N 2830/36 (20130101) C12N 2840/445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213480 | PLACE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692630 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213481 | PLACE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213487 | Wyss-Coray et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT AFFAIRS OFFICE OF THE GENERAL COUNSEL (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); Thomas A. Rando (Stanford, California); Markus Britschgi (Allscwil, Switzerland); Kaspar Rufibach (Basel, Switzerland); Saul A. Villeda (Lancaster, California) |
| ABSTRACT | Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/7088 (20130101) A61K 38/19 (20130101) A61K 38/45 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/24 (20130101) C07K 16/28 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Enzymes C12Y 207/10001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213502 | Zheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tongji University (Shanghai, China PRC); Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | Tongji University (Shanghai, China PRC); Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| INVENTOR(S) | Jialin Zheng (Shanghai, China PRC); Changhai Tian (Omaha, Nebraska) |
| ABSTRACT | The present invention provides in general methods for transdifferentiation of a somatic cell, e.g., a fibroblast, to a dopaminergic precursor. Specifically, the present invention relates to methods for making iDP cells, and methods for using them in, e.g., treating neurodegenerative diseases such as Parkinson's disease. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/578059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213507 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Jonathan Ma Levy (Cambridge, Massachusetts); Wei Hsi Yeh (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods of delivering “split” Cas9 protein or nucleobase editors into a cell, e.g., via a recombinant adeno-associated virus (rAAV), to form a complete and functional Cas9 protein or nucleobase editor. The Cas9 protein or the nucleobase editor is split into two sections, each fused with one part of an intein system (e.g., intein-N and intein-C encoded by dnaEn and dnaEc, respectively). Upon co-expression, the two sections of the Cas9 protein or nucleobase editor are ligated together via intein-mediated protein splicing. Recombinant AAV vectors and particles for the delivery of the split Cas9 protein or nucleobase editor, and methods of using such AAV vectors and particles are also provided. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692925 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 2319/09 (20130101) C07K 2319/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) C12N 15/63 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2830/36 (20130101) C12N 2830/48 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2521/539 (20130101) Enzymes C12Y 305/04001 (20130101) C12Y 305/04004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213508 | Glorioso, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Joseph C. Glorioso, III (Pittsburgh, Pennsylvania); Justus Cohen (Allison Park, Pennsylvania); Yoshitaka Miyagawa (Pittsburgh, Pennsylvania); David Krisky (Sewickley, Pennsylvania); James Wechuck (Glenshaw, Pennsylvania); Darren Wolfe (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed is a method for administering a transgene into a fibroblast in a subject comprising: a) providing a herpes simplex virus (HSV) comprising a recombinant herpes simplex virus genome, wherein said recombinant herpes simplex virus genome comprises one or more transgenes encoding a polypeptide to be expressed in said fibroblast; and b) providing a pharmaceutically acceptable carrier; wherein said HSV has reduced cytotoxicity as compared to a wild-type herpes simplex virus. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2710/16621 (20130101) C12N 2710/16643 (20130101) C12N 2710/16671 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213534 | CUNNINGHAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian T. CUNNINGHAM (Champaign, Illinois); Taylor D. CANADY (Champaign, Illinois); Nantao LI (Champaign, Illinois); Andrew M. SMITH (Savoy, Illinois); Yi LU (Champaign, Illinois); Hanyuan ZHANG (Champaign, Illinois) |
| ABSTRACT | Assays using nanoparticle probes can be used to detect a target oligonucleotide with digital resolution by measuring the peak wavelengths and/or peak intensities of resonantly reflected light from locations on the surface of a photonic crystal (PC). The PC is functionalized with a capture oligonucleotide that binds to a nanoparticle probe that has bound to the target analyte. The binding of the nanoparticle probe to the PC shifts the peak wavelength and reduces the peak intensity of the resonantly reflected light at the binding location. An example nanoparticle probe includes a metallic nanoparticle conjugated to a probe oligonucleotide bound to a protector oligonucleotide. The probe oligonucleotide includes a first portion complementary to the target oligonucleotide and a second portion complementary to the capture oligonucleotide. The target oligonucleotide can bind to the probe oligonucleotide and displace the protector oligonucleotide, which exposes the second portion and enables binding to the capture oligonucleotide. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 17/606567 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6837 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213558 | Levin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Convergent Genomics, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Gilpin Levin (South San Francisco, California); Kevin Gregory Phillips (South San Francisco, California); Mahdi Goudarzi (South San Francisco, California) |
| ABSTRACT | The present disclosure provides methods and systems directed to urine-based detection of urologic conditions. A method for identifying or monitoring a urologic condition of a subject may comprise processing a cell-free biological sample obtained or derived from the subject to generate a dataset indicative of a presence, absence, or relative assessment of the urologic condition; using a trained algorithm to process the dataset to determine a quantitative measure indicative of the presence, absence, or relative assessment of the urologic condition; based at least in part on the quantitative measure, identifying or providing an indication of the urologic condition with (i) a sensitivity of at least about 90%, (ii) a specificity of at least about 90%, (iii) a positive predictive value of at least about 90%, or (iv) a negative predictive value of at least about 90%; and electronically outputting a report that provides an indication of the urologic condition. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/612150 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213563 | Perou et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Washington University (St. Louis, Missouri); University of Utah Research Foundation (Salt Lake City, Utah); British Columbia Cancer Agency Branch (Vancouver, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles M. Perou (Carrboro, North Carolina); Joel S. Parker (Apex, North Carolina); James Stephen Marron (Durham, North Carolina); Andrew Nobel (Chapel Hill, North Carolina); Philip S. Bernard (Salt Lake City, Utah); Matthew J. Ellis (St. Louis, Missouri); Elaine Mardis (Troy, Illinois); Torsten O. Nielson (North Vancouver, Canada); Maggie Chon U. Cheang (Vancouver, Canada) |
| ABSTRACT | Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702567 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 40/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214292 | AUGUSTINE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. AUGUSTINE (Oakland, California); John MADSEN (Oakland, California); Johnny PHAN (Oakland, California); Joseph POURTABIB (Oakland, California); Sophia Noelle FRICKE (Oakland, California); Shahab CHIZARI (Oakland, California); Nam K. TRAN (Oakland, California) |
| ABSTRACT | Methods and instrumentation for determining the water content of a body fluid such as blood plasma by portable nuclear magnetic resonance (NMR) relaxometry are provided. |
| FILED | Monday, April 06, 2020 |
| APPL NO | 17/600901 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/082 (20130101) Original (OR) Class G01N 33/49 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214332 | Lewinsohn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); ViTi Incorporated (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deborah Lewinsohn (Portland, Oregon); Melissa Nyendak (Portland, Oregon); Gwendolyn Swarbrick (Portland, Oregon); Jeffery Mooney (Portland, Oregon) |
| ABSTRACT | Methods for detecting an immune response to Mycobacterium tuberculosis are provided. Aspects of the methods include contacting a biological sample comprising T cells from a subject with at least one M. tuberculosis peptide and determining the presence of T cells in the biological sample that specifically recognize the amino acid sequence of the at least one peptide, wherein the presence of T cells that specifically recognize the amino acid sequence of the at least one peptide indicates the subject has an immune response to M. tuberculosis. In certain aspects, the methods of the present disclosure may include treating a subject identified as having an immune response to M. tuberculosis. Also provided are a skin test and immunoassay kits for practicing the disclosed methods. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/614271 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/41 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/133 (20130101) A61K 31/496 (20130101) A61K 31/4409 (20130101) A61K 31/4965 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) Original (OR) Class G01N 33/6863 (20130101) G01N 33/54306 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214333 | HERING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (MINNEAPOLIS, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (MINNEAPOLIS, Minnesota) |
| INVENTOR(S) | Bernhard J. HERING (Minneapolis, Minnesota); Sabarinathan RAMACHANDRAN (Minneapolis, Minnesota); Amar SINGH (Minneapolis, Minnesota) |
| ABSTRACT | In certain embodiments, the present invention provides methods of identifying and treating a transplant recipient patient having transplantation tolerance induced by apoptotic donor leukocytes infused under cover of transient immunotherapy. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604314 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5094 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214337 | TSOURKAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Andrew TSOURKAS (Bryn Mawr, Pennsylvania); James Z. HUI (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention relates to to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508742 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) A61K 47/65 (20170801) A61K 47/6855 (20170801) A61K 49/1875 (20130101) Peptides C07K 14/31 (20130101) C07K 17/00 (20130101) C07K 17/06 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/54353 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214350 | GUNDERSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Kevin L. GUNDERSON (San Diego, California); Norihito MURANAKA (San Diego, California) |
| ABSTRACT | The present disclosure relates to methods and kits for forming a stable complex comprising a binding agent and a target (e.g., a macromolecule). In some embodiments, the target comprises a peptide, a polypeptide, or a protein to be analyzed. In some embodiments, the present disclosure relates to formation of a stable complex comprising a binding agent and a target (e.g., a macromolecule) to be analyzed in a method which employs barcoding and nucleic acid encoding of molecular recognition events, and/or detectable labels. Provided herein is also a programmable system for information transfer comprising one or more adaptor molecules. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505557 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214355 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Ku-Lung Hsu (Charlottesville, Virginia); Heung Sik Hahm (Atlanta, Georgia); Emmanuel K. Toroitich (Charlottesville, Virginia); Jeffrey W. Brulet (Glen Allen, Virginia); Adam L. Borne (Charlottesville, Virginia); Adam Herman Libby (Charlottesville, Virginia); Kun Yuan (Charlottesville, Virginia) |
| ABSTRACT | Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441544 |
| CURRENT CPC | Heterocyclic Compounds C07D 249/04 (20130101) C07D 249/08 (20130101) Peptides C07K 2/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 2500/32 (20130101) C12N 2501/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214365 | CABRERA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert M. CABRERA (Houston, Texas); Richard H. FINNELL (Austin, Texas) |
| ABSTRACT | The invention relates to devices and methods for detecting the presence of antibodies to folic acid in a sample. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699706 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Peptides C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/82 (20130101) Original (OR) Class G01N 33/6854 (20130101) G01N 33/54366 (20130101) G01N 2800/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214413 | Kuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Braden Kuo (Newton, Massachusetts); Christopher Nguyen (Cambridge, Massachusetts); Roberta Sclocco (Cambridge, Massachusetts); Vitaly Napadow (Winchester, Massachusetts) |
| ABSTRACT | A method for evaluating gastric and upper small intestine motility and emptying in a gastrointestinal tract of a subject using magnetic resonance imaging includes administering a contrast agent to the subject; acquiring, using an MRI system, a set of MR data from the subject using a three-dimensional volumetric pulse sequence. The volumetric pulse sequence has a temporal resolution and a spatial resolution configured to facilitate measurement of volumetric and motility parameters. The method further includes reconstructing a set of images using the set of MR data, segmenting each image in the set of images to isolate a region of interest in the gastrointestinal tract of the subject, determining at least one volumetric and motility parameter based on the set of segmented images, and generating a report indicating the at least one volumetric or motility parameter. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/609667 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0013 (20130101) A61B 5/055 (20130101) A61B 5/4238 (20130101) A61B 5/7285 (20130101) A61B 2576/02 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4822 (20130101) Original (OR) Class G01R 33/5601 (20130101) G01R 33/5608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214414 | Emir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uzay Emir (West Lafayette, Indiana); Mark Chiew (West Lafayette, Indiana) |
| ABSTRACT | A method of performing magnetic resonance spectroscopic imaging (MRSI) measures neurochemical profiles over larger regions non-invasively. The method includes transmitting a multi-slice excitation pulse through tissue, the multi-slice excitation pulse configured to generate multi-slice MRSI signals. The method also includes performing density weighted concentric ring acquisition on the multi-slice MRSI signals. The method further includes receiving the generated multi-slice MRSI signals in a plurality of sensors disposed in various locations around the tissue. Imaging data is reconstructed based on the acquired imaging signals. A representation of the data is displayed. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/607774 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) G01R 33/4824 (20130101) G01R 33/4828 (20130101) G01R 33/4835 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214415 | Brender et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented, by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey R. Brender (Washington, District of Columbia); James B. Mitchell (Damascus, Maryland); Kazutoshi Yamamoto (North Bethesda, Maryland); Shun Kishimoto (Rockville, Maryland); Jeeva P. Munasinghe (Rockville, Maryland); Hellmut Merkle (Bethesda, Maryland); Murali K. Cherukuri (Potomac, Maryland) |
| ABSTRACT | Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576283 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) G01R 33/5608 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 2207/10088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215584 | Mendlow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Translational Imaging Innovations, Inc. (Hickory, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Micaela R. Mendlow (Jersey City, New Jersey); Eric L. Buckland (Hickory, North Carolina) |
| ABSTRACT | A model eye for calibrating a retinal imaging system is provided including a backplane having a negative radius of curvature R centered on the optical axis and a clear aperture diameter D2; a distance h along the optical axis from the nodal point to the backplane; an unobstructed field of view 2θ; a closed fluid fillable housing; a mechanical system for mounting, aligning, and preserving spacings of the elements of the model eye; and a pattern applied to the backplane, the pattern having a rotational symmetry and a radial repeating unit, extending substantially across the clear aperture, that spatially modulates intensity of light reflected from, or transmitted through, a surface of the backplane. D2/D1 is greater than 2, an absolute value of R/h is greater than 0.5, and 2θ is greater than zero (0) degrees. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568306 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/0025 (20130101) Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/0012 (20130101) G06T 7/60 (20130101) G06T 7/80 (20170101) Original (OR) Class G06T 2207/30041 (20130101) G06T 2207/30204 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215625 | XIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Jiong XIA (Houston, Texas); Jaime GATENO (Bellaire, Texas); Dinggang SHEN (Chapel Hill, North Carolina) |
| ABSTRACT | Systems and methods for estimating a patient-specific reference bone shape model for a patient with craniomaxillofacial (CMF) defects are described herein. An example method includes receiving a twodimensional (“2D”) pre-trauma image of a subject, and generating a three-dimensional (“3D”) facial surface model for the subject from the 2D pre-trauma image. The method also includes providing a correlation model between 3D facial and bone surfaces, and estimating a reference bone model for the subject using the 3D facial surface model and the correlation model. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 17/600909 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/501 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) Image Data Processing or Generation, in General G06T 7/344 (20170101) G06T 17/20 (20130101) Original (OR) Class G06T 19/20 (20130101) G06T 2207/10081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30008 (20130101) G06T 2207/30201 (20130101) G06T 2210/41 (20130101) G06T 2219/2004 (20130101) G06T 2219/2021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215935 | Chennubhotla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Srinivas C. Chennubhotla (Pittsburgh, Pennsylvania); Filippo Pullara (Pittsburgh, Pennsylvania); Samantha A. Furman (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of characterizing cellular phenotypes includes receiving multi-parameter cellular and sub-cellular imaging data for a number of tissue samples from a number of patients or a number of multicellular in vitro models, performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data to create segmented multi-parameter cellular and sub-cellular imaging data, and performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes. The recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/605423 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6218 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215963 | Constantine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory M. Constantine (Baden, Pennsylvania); Timothy Billiar (Presto, Pennsylvania); Qi Mi (Pittsburgh, Pennsylvania); Rami Namas (Bethel Park, Pennsylvania); Lukas Schimunek (Rimbach, Germany); Yoram Vodovotz (Sewickley, Pennsylvania) |
| ABSTRACT | Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473726 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 40/00 (20190201) G16B 40/30 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) Original (OR) Class G16H 50/70 (20180101) G16H 70/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216047 | CLEMMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. CLEMMER (Bloomington, Indiana); Martin F. JARROLD (Bloomington, Indiana); Tarick J. EL-BABA (Bloomington, Indiana); Corinne A. LUTOMSKI (Bloomington, Indiana) |
| ABSTRACT | A method for analyzing charged particles may include generating, in or into an ion source region, charged particles from a sample of particles, causing the charged particles to enter a mass spectrometer from the ion source region at each of a plurality of differing physical and/or chemical conditions in a range of physical and/or chemical conditions in which the sample particles undergo structural changes, controlling the mass spectrometer to measure at least the charge magnitudes of the generated charged particles at each of the plurality of differing physical and/or chemical conditions, determining, with a processor, an average charge magnitude of the generated charged particles at each of the plurality of differing physical and/or chemical conditions based on the measured charge magnitudes, and determining, with the processor, an average charge magnitude profile over the range of physical and/or chemical conditions based on the determined average charge magnitudes. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/602000 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0031 (20130101) H01J 49/165 (20130101) Original (OR) Class H01J 49/0468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220211059 | Omenetto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tufts University (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fiorenzo Omenetto (Lexington, Massachusetts); David Kaplan (Concord, Massachusetts); Benedetto Marelli (Somerville, Massachusetts); Mark Brenckle (Acton, Massachusetts) |
| ABSTRACT | Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/444293 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 7/16 (20130101) Original (OR) Class A23B 7/154 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/3463 (20130101) A23L 3/3526 (20130101) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Peptides C07K 14/43586 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211534 | Tomblin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wichita State University (Wichita, Kansas); Commercial Chemistries, LLC (Cottonwood Heights, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Tomblin (Wichita, Kansas); Thomas Aldag (Wichita, Kansas); William T. McCarvill (Cottonwood Heights, Utah); Kimberly M. Reuter (Wichita, Kansas); Joel D. White (Wichita, Kansas); Andrea C. Meyer (Bel Aire, Kansas) |
| ABSTRACT | Methods of using fiber-reinforced composite articles useful in supporting or immobilizing an injured body part is disclosed. The composite is a multi-layer, flexible precursor including fiber reinforcement plies, which can be rapidly cured into a rigid body using a thermosetting resin. Methods of making and using the same are also disclosed, along with kits containing such composite articles. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698398 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/01 (20130101) A61F 5/0585 (20130101) A61F 5/05825 (20130101) Original (OR) Class A61F 5/05841 (20130101) A61F 13/04 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/08 (20130101) A61L 15/12 (20130101) A61L 15/14 (20130101) A61L 15/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211959 | Montgomery et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wolf Technical Services, Inc. (Fishers, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa Montgomery (Alexandria, Virginia); Aaron James Tolly (Fishers, Indiana); Jarrett Waters (Camby, Indiana) |
| ABSTRACT | An incision and dilation apparatus performs an incision in and dilates select tissue of a mammal. The apparatus includes a blade member, a dilator, and a frame. The blade member includes a blade having a cutting edge. The dilator is configured to dilate the select tissue. The frame includes a blade guide, and is adapted to position the blade guide over the select tissue. The blade guide retains the blade member in first and second perpendicular directions and allows substantially linear movement of the blade member in a third direction. The frame also supports the dilator and allows movement of the dilator in the third direction. The dilator includes a second blade guide that retains the blade member in first and second perpendicular directions and allow substantially linear movement of the blade member relative to the dilator in a third direction. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 17/610645 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3211 (20130101) A61B 2017/320052 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) Original (OR) Class A61M 29/02 (20130101) A61M 2029/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212002 | Broderick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Inovio Pharmaceuticals, Inc. (Plymouth Meeting, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kate Broderick (San Diego, California); Jay McCoy (Temecula, California); Stephen V. Kemmerrer (San Diego, California) |
| ABSTRACT | The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698135 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/53 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) Original (OR) Class A61N 1/0412 (20130101) A61N 1/0424 (20130101) A61N 1/0476 (20130101) Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220212047 — ZWITTERIONIC AND GLUCOSIDE SURFACTANT FORMULATIONS FOR FIRE-FIGHTING FOAM APPLICATIONS
| US 20220212047 | Ananth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ramagopal Ananth (Bryn Mawr, Pennsylvania); Arthur W. Snow (Alexandria, Virginia); Spencer L. Giles (Lorton, Virginia); Matthew Davis (Ridgecrest, California); Katherine Hinnant (Washington, District of Columbia) |
| ABSTRACT | A composition having water and first and second surfactants having the formulas below. The values m and y are non-negative integers, and n and x are positive integers. R is a zwitterionic group. R′ is a siloxane group. A foam of the composition may be used to extinguish a fire. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569931 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 1/0042 (20130101) Original (OR) Class A62D 1/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212256 | Nassar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abdalla R. Nassar (State College, Pennsylvania); Alexander J. Dunbar (Waltham, Massachusetts); Edward W. Reutzel (State College, Pennsylvania) |
| ABSTRACT | Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655636 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0208 (20130101) G01J 3/443 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212406 | Lentz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Sec'y of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Lentz (Niceville, Florida) |
| ABSTRACT | A resin curing system provided by stereolithography (SLA) three-dimensional (3D) printer includes a pair of Risley prism for optical steering of laser energy to achieve improved resolution. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/567932 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/34 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) B29C 64/268 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212783 | Goodwin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Douglas Andrew Goodwin (Fort Worth, Texas); David Andrew Prater (Hurst, Texas); Eric Stephen Olson (Fort Worth, Texas); David Bryan Roberts (Bedford, Texas); Chia-Wei Su (Lewisville, Texas); Michael David Trantham (Arlington, Texas); Charles Eric Covington (Colleyville, Texas) |
| ABSTRACT | A multimode clutch assembly is positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling unit having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly shifts the bypass assembly between engaged and disengaged positions. An engagement status sensor is configured to determine the engagement status of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit is enabled such that the clutch assembly is configured for unidirectional torque transfer. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516093 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/08 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 41/04 (20130101) F16D 2041/0603 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212908 | Frizzell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew James Frizzell (Ballwin, Missouri); Joseph Edward Flach (St. Charles, Missouri); Richard Kurt Wagner (St. Louis, Missouri); Larry Paul Boyer (Warrenton, Missouri) |
| ABSTRACT | Engine installation systems and related methods. An engine installation system includes an adapter cradle and a transport dolly. The adapter cradle is configured to support the engine, and the transport dolly is configured to be selectively and operatively coupled to the adapter cradle to support the adapter cradle to facilitate transporting the adapter cradle and the engine across a ground surface. The adapter cradle is configured to be selectively coupled to each of the transport dolly and the vehicle. The adapter cradle is configured to pivot relative to the transport dolly or relative to the vehicle to transition between a transport configuration and an upright configuration. In examples, methods of installing an engine within an engine bay of a vehicle include positioning the engine beneath the engine bay, pivoting the engine relative to the vehicle, and lifting the engine into the engine bay. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505500 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/10 (20170101) B64F 5/50 (20170101) Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212947 | Vernon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan P. Vernon (Beavercreek, Ohio); Peter R. Stevenson (Dayton, Ohio); William J. Kennedy (Dayton, Ohio) |
| ABSTRACT | A method for controlling the optical properties of a material comprises the steps of (1) applying a dopant to an undoped TMD film by solution dip-coating the TMD, wherein the solution is a dopant solution consisting of one of NADH (nicotinamide adenine dinucleotide) and TCNQ (7,7,8,8-tetracyanoquinodimethane), wherein the doped TMD film exhibits an altered refractive index (n) and extinction coefficient (k) in comparison to the undoped TMD film. The dopant solution is a 0.1M solution of NADH in anhydrous acetonitrile or a 0.1M solution of TCNQ in anhydrous methanol. Rinsing the doped TMD film with a solvent consisting of one of anhydrous acetonitrile and anhydrous methanol to create an undoped TMD film exhibiting a refractive index (n) and extinction coefficient (k) substantially similar to the original undoped TMD film. The TMD is selected from the group consisting of MoS2, MoSe2, WS2, WSe2, and TiS2. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/644574 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/60 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/02 (20130101) C23C 16/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212959 | Ganjigunte Ramaswamy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Swathi Iyer Ganjigunte Ramaswamy (Alexandria, Virginia); Manoj K. Kolel-Veetil (Annandale, Virginia) |
| ABSTRACT | A method of: forming an aerosol of an aqueous liquid, and directing the aerosol into a plasma. The method can be used to degrade a polyfluoroalkyl substance. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/570367 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) Original (OR) Class C02F 1/4608 (20130101) C02F 2101/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213052 | Aube et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Jeff Aube (Chapel Hill, North Carolina); Sudeshna Roy (Lawrence, Kansas); Liang XU (Lawrence, Kansas); Xiaoqing WU (Lawrence, Kansas); Lan LAN (Lawrence, Kansas) |
| ABSTRACT | The present technology is directed to compounds that inhibit of the interaction of RNA-binding proteins with RNA, intermediates thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I). |
| FILED | Friday, May 01, 2020 |
| APPL NO | 17/607003 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 209/42 (20130101) C07D 333/60 (20130101) Original (OR) Class C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213219 | CONKLIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas S. CONKLIN (Niskayuna, New York); Cheryl EIFERT (Roslindale, Massachusetts); Antonis KOURTIPIS (Jacksonville, Florida); Leila KOKABEE (Albany, New York); Xiauhui WANG (Albany, New York) |
| ABSTRACT | Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over 5 half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 10 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) C07K 16/40 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) Enzymes C12Y 207/10001 (20130101) C12Y 207/10002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/57415 (20130101) G01N 2333/9121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213261 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett D. Martin (Washington, District of Columbia); Jawad Naciri (Arlington, Virginia); Banahalli R. Ratna (Alexandria, Virginia) |
| ABSTRACT | An interpenetrating network (IPN) polymer membrane material includes a soft polyurethane interspersed with a crosslinked conducting polymer. The material can be reversibly “switched” between its oxidized and reduced states by the application of a small voltage, ˜1 to 4 volts, thus modulating its diffusivity. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703693 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 81/00 (20130101) C08G 2261/70 (20130101) C08G 2261/122 (20130101) C08G 2261/126 (20130101) C08G 2261/514 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/127 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213262 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett D. Martin (Washington, District of Columbia); Jawad Naciri (Arlington, Virginia); Banahalli R. Ratna (Alexandria, Virginia) |
| ABSTRACT | An interpenetrating network (IPN) polymer membrane material includes a soft polyurethane interspersed with a crosslinked conducting polymer. The material can be reversibly “switched” between its oxidized and reduced states by the application of a small voltage, ˜1 to 4 volts, thus modulating its diffusivity. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/703729 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) Original (OR) Class C08G 81/00 (20130101) C08G 2261/70 (20130101) C08G 2261/122 (20130101) C08G 2261/126 (20130101) C08G 2261/514 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/127 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213677 | Swope et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Lawson Swope (San Diego, California); Leonard David Sinfield (Rail Road Flat, California); Patrick John Earley (San Diego, California); Alexander Gregory Stevens-Bracy (Chula Vista, California) |
| ABSTRACT | A filter for filtering storm water in an outfall pipe comprising: a line comprising an anchor attachment point at a proximal end of the line; and a plurality of individual treatment units (ITUs) securely connected in series to the line with a gap between adjacent ITUs, wherein each ITU has a size and shape capable of fitting inside the outfall pipe, and wherein each ITU comprises a mesh cage configured to filter contaminants out of the storm water. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140982 |
| CURRENT CPC | Separation B01D 29/25 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 2103/001 (20130101) Sewers; Cesspools E03F 5/0404 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213796 | Rudrapatna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Nagaraja Rudrapatna (Chandler, Arizona); Thomas Bronson (Mesa, Arizona); David Chou (Phoenix, Arizona); Christopher Zollars (Tempe, Arizona) |
| ABSTRACT | A low-leakage seal assembly for a turbomachine's combustor-turbine interface. A turbomachine includes a combustion chamber that receives compressed air for combustion from a compressor. The combustion chamber is defined by a combustion liner terminating in a seal ring where the seal ring has an enlarged head that is thicker than the remainder of the seal ring. A transition liner directs combustion gases from the combustion chamber to the turbine and has three walls forming a cavity with an open end. The seal ring extends through the open end and the head nests in the cavity. The transition liner and the seal ring are parts of a low-leakage seal assembly that is exposed on one side to the compressed air and that is exposed on another side to the combustion gases. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142460 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/023 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/35 (20130101) F05D 2240/55 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/54 (20130101) F23R 3/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213797 | Rudrapatna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Nagaraja Rudrapatna (Chandler, Arizona); Thomas Bronson (Mesa, Arizona); Christopher Zollars (Tempe, Arizona) |
| ABSTRACT | A low-leakage seal assembly for a turbomachine's combustor-turbine interface. A turbomachine includes a combustion chamber that receives compressed air for combustion from a compressor. The combustion chamber is defined by a combustion liner terminating in a seal ring where the seal ring has an enlarged head that is thicker than the remainder of the seal ring. A transition liner directs combustion gases from the combustion chamber to the turbine and has three walls forming a cavity with an open end. The seal ring extends through the open end and the head nests in the cavity. The transition liner and the seal ring are parts of a low-leakage seal assembly that is exposed on one side to the compressed air and that is exposed on another side to the combustion gases. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/453525 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/023 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/35 (20130101) F05D 2240/55 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/54 (20130101) F23R 3/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214028 | Lentz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Sec'y of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Lentz (Niceville, Florida) |
| ABSTRACT | A cycloidal diffractive waveplate based star simulator generates a star field with very high precision star locations and accurate brightness. The present disclosure provides a star simulator that allows for a large FOV, modular, multi-star simulator capable of very high precision dynamic star locations for testing of high accuracy, large FOV star trackers. The system is composed of a light source, a polarization grating-based image [1], and an opto-mechanical system for steering the light. The light is projected onto a diffuse screen where the light is scattered, creating a functional point source at the screen. A star tracker or other device under test views the screen which has a multitude of projected spots (each with its own light source and beam steering device) positioned in a star field distribution appropriate for the simulated viewing direction. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567578 |
| CURRENT CPC | Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 5/02 (20130101) F21V 9/14 (20130101) F21V 9/40 (20180201) F21V 14/06 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to Uses or Applications of Lighting Devices or Systems F21W 2121/008 (20130101) Optical Elements, Systems, or Apparatus G02B 5/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214144 | Indelicato et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Indelicato (Crestview, Florida); Melvin White (Centerville, Ohio); David Feibus (Dayton, Ohio); Meghan Berlingo (Washington, District of Columbia); David Beargie (Crestview, Florida); Nicholas Martin (Dayton, Ohio) |
| ABSTRACT | An integrated airspace defense system for identifying and locating a suspicious unmanned aerial vehicle. The system including at least one detection device to monitor the air space and provide a detection information; a computer to process the detection information and identifying the presence of suspicious unmanned aerial vehicles (UAVs) using a sequence of detection algorithms. The integrated airspace defense system identifies and locates the suspicious UAV. In at least one embodiment the integrated airspace defense system is capable of capturing or destroying the suspicious UAV. |
| FILED | Tuesday, February 09, 2021 |
| APPL NO | 17/171340 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/02 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/04 (20200101) G01S 17/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214219 | FARAON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei FARAON (Pasadena, California); Seyedeh Mahsa KAMALI (Pasadena, California); Amir ARBABI (Sunderland, Massachusetts); Ehsan ARBABI (Pasadena, California) |
| ABSTRACT | Metasurfaces for polarimetric imaging are disclosed. The described devices are built to split and focus light to various pixels on an image sensor for different polarization bases. This allows for complete characterization of polarization by measuring the four Stokes parameters over the area of each superpixel, which corresponds to the area of the pixels on the image sensor. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 16/777491 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0224 (20130101) G01J 3/0229 (20130101) G01J 4/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214244 | HARRIGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SIKORSKY AIRCRAFT CORPORATION (Stratford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew HARRIGAN (Horseheads, New York); Theodore MEYER (Pavilion, New York); Darryl M. TONI (Clinton, Connecticut); Avinash SARLASHKAR (Pittsford, New York) |
| ABSTRACT | A method of determining structural health of an assembly includes determining a Margin of Safety (MSH) value for at least one of a plurality of components in the assembly when the assembly is healthy. The method includes determining if damage to the assembly has occurred. If damage to the assembly has occurred, the method includes determining a Margin of Safety (MSD) value for at least one of the plurality of components in the assembly when the assembly is damaged. The method includes determining a Structural Health Index (SHI) of the assembly based on the MSD value for the at least one undamaged component. |
| FILED | Wednesday, October 18, 2017 |
| APPL NO | 16/757212 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) B64D 2045/0085 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0033 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214256 | Spowart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan E. Spowart (Beavercreek, Ohio); Colin Rowbottom (Englewood, Florida); Carly S. Hauser (Ripley, Ohio); Eric A. Lindgren (Beavercreek, Ohio) |
| ABSTRACT | The present invention relates to devices for measuring property changes via in-situ micro-viscometry and methods of using same. The aforementioned device is inexpensive and can be used to quickly and accurately measure numerous physical and chemical property changes, including but not limited to the rate of chemical cure, change in tack, and rate of mass loss, for example, rate of moisture, solvent and/or plasticizer change. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702220 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/00 (20130101) Original (OR) Class G01N 2011/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214304 | ROSENSTEIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob K. ROSENSTEIN (Providence, Rhode Island); Kangping HU (Providence, Rhode Island) |
| ABSTRACT | A complementary metal-oxide-semiconductor sensor array includes an active sensing area of pixels arranged in an array with a pitch, each pixel including an exposed surface electrode alongside switches and logic gates, and non-overlapping clocks configured to rapidly charge and discharge the exposed surface electrode, wherein control signals steer a switched output current between shared column outputs. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497603 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4148 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 27/2605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214355 | Hsu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Ku-Lung Hsu (Charlottesville, Virginia); Heung Sik Hahm (Atlanta, Georgia); Emmanuel K. Toroitich (Charlottesville, Virginia); Jeffrey W. Brulet (Glen Allen, Virginia); Adam L. Borne (Charlottesville, Virginia); Adam Herman Libby (Charlottesville, Virginia); Kun Yuan (Charlottesville, Virginia) |
| ABSTRACT | Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441544 |
| CURRENT CPC | Heterocyclic Compounds C07D 249/04 (20130101) C07D 249/08 (20130101) Peptides C07K 2/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 2500/32 (20130101) C12N 2501/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/6845 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214479 | Sell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Sell (Palo Alto, California); Jonathan A. Fan (Los Altos, California); Thaibao Phan (Redwood City, California); Jianji Yang (Menlo Park, California) |
| ABSTRACT | Certain examples are directed to optical elements or devices that pass or process the light based on a set of connectable metasurface elements having been topology optimized. The connectable metasurface elements are independently optimized or designed to have each section having its own metasurface phase profile corresponding to a desired phase profile. In this way, such devices need not be designed or manufactured by importing a large number of results into simulation efforts, thereby realizing significant saving in terms of optimization time and computational power. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/606729 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/188 (20130101) Original (OR) Class G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214669 | Crawford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Lara S. Crawford (Belmont, California); Morad Behandish (Foster City, California) |
| ABSTRACT | One embodiment of the present disclosure provides a system and method for facilitating a search for a hybrid-manufacturing process plan for manufacturing an object. During operation, the system can obtain a set of partial order constraints constraining the order in which a set of at least two manufacturing actions, corresponding to addition or removal of predefined regions of space, appear in a process plan. The system can constrain, based on the set of partial order constraints, a search space. The search space can correspond to a tree in which the nodes represent the object's state and the edges represent available actions at each node. The system can then determine a set of optimized process plans represented by orderings of the actions, corresponding to paths on the search tree, that produce the desired final state in a cost-effective manner. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140915 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4183 (20130101) G05B 19/4188 (20130101) G05B 19/41865 (20130101) Original (OR) Class G05B 19/41885 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215069 | GUHA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SAIKAT GUHA (TUCSON, Arizona); CHRISTOS GAGATSOS (TUCSON, Arizona) |
| ABSTRACT | A method for cluster-state quantum computing method includes transforming a Gaussian graph state into a non-Gaussian percolated graph state by probabilistically subtracting one photon from each of a plurality of modes forming the Gaussian graph state. The method also includes determining cat-basis qubits of the non-Gaussian percolated graph state for which one photon was successfully subtracted from a corresponding one of the modes, and identifying in the non-Gaussian percolated graph state a renormalized graph of logical qubits connected by percolation highways. The logical qubits and percolation highways are formed from the cat-basis qubits. The renormalized graph and the non-Gaussian percolated graph state are outputted to a one-way quantum computer to implementing a quantum computing algorithm. |
| FILED | Saturday, May 02, 2020 |
| APPL NO | 17/594874 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/14 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215233 | Buehler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Markus J. Buehler (Boxford, Massachusetts); Chi Hua Yu (New Taipei City, Taiwan); Zhenze Yang (Cambridge, Massachusetts) |
| ABSTRACT | Materials-by-design is a new paradigm to develop novel high-performance materials. However, finding materials with superior properties is often computationally or experimentally intractable because of the astronomical number of combinations in design spaces. The disclosure is a novel AI-based approach, implemented in a game-theory based generative adversarial neural network (GAN), to bridge the gap between the physical performance and design space. A end-to-end deep learning model predicts physical fields like stress or strain directly from the material geometry and microstructure. The model reaches an astonishing accuracy not only for predicted field data but also for secondary predictions, such as average residual stress at R2˜0.96). Furthermore, the proposed approach offers extensibility by predicting complex materials behavior regardless of shapes, boundary conditions and geometrical hierarchy. The deep learning model demonstrates not only the robustness of predicting multi-physical fields, scalability, and extensibility. The disclosure may alter physical modeling and simulations by incorporating material geometry and boundary conditions into a graphical representation, and vastly improves the efficiency of evaluating physical properties of hierarchical materials directly from the geometry of its structural makeup. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/646505 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) Electric Digital Data Processing G06F 30/20 (20200101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215480 | Barash et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Graphika Technologies Inc. (Beaverton, Oregon); The Johns Hopkins University (Baltimore, Maryland); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Barash (New York, New York); Christopher J. Cameron (Ithaca, New York); Michael W. Macy (Ithaca, New York); Clayton R. Fink (Silver Spring, Maryland); Aurora C. Schmidt (Fulton, Maryland); John W. Kelly (New York, New York) |
| ABSTRACT | A method for determining social contagion while monitoring social media may be executable via operation of configured processing circuitry. The method may include receiving data indicative of social media activity of a plurality of users, selecting features of interest from the data, building a relationship network indicative of connections between the users and local networks to which various ones of the users belong, analyzing the features of interest to determine candidate features for classification as social contagion, determining a complex social contagion score for the candidate features, and providing an indication regarding the classification as social contagion based on the complex social contagion score. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503711 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/285 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215955 | Sajda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Paul Sajda (New York, New York); Xueqing Liu (New York, New York) |
| ABSTRACT | The present subject matter relates to techniques for hierarchical deep transcoding. The disclosed system can include a processor that can be configured to receive a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and reconstruct a latent source space from the fMRI data and/or the EEG data by decoding the EEG data and/or the fMRI data to a latent source space. The fMRI data and the EEG data can be simultaneously acquired. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494562 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216109 | Snure et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Govemment of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael R. Snure (Oakwood, Ohio); Eric W. Blanton (Dayton, Ohio); Jeff L. Brown (Fairborn, Ohio); Albert M. Hilton (Centerville, Ohio) |
| ABSTRACT | A method for making a selective-area lift-off thin film comprises depositing a van der Waals (vdW) buffer on a substrate; depositing a thin film material (or device structure) on the van der Waals buffer; depositing an adhesion layer on the thin film material; forming a stressor layer on top of the thin film layer; and bonding a handle layer to the stressor layer. Force may be applied to the layered structure by one or more of rolling, bending, and shearing. The area selected for lift-off may be defined by one of laser cutting and mechanical scribing. The vdW buffer includes one or more of hBN, graphite, and graphene. The handle layer is a one of a polyimide tape, thermal release tape, UV release tape, water- or solvent-soluble tape, Kapton tape, and Scotch tape. The stressor layer is a metal film, e.g. Ni, Cr, Ti. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/142068 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/6836 (20130101) H01L 21/7806 (20130101) Original (OR) Class H01L 2221/68368 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216505 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bioenno Tech LLC (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Santa Ana, California); Chunhu Tan (Santa Ana, California); Tianyu Meng (Santa Ana, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140690 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216554 | Lopotko et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xentris Wireless LLC (Addison, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Lopotko (Lisle, Illinois); Michael Joseph Culen (Glen Ellyn, Illinois); Norikiyo I. Honda (Elk Grove, Illinois); Cameron Eckert (Markle, Indiana) |
| ABSTRACT | A battery with a generally cuboid body with a top face. A cylindrical terminal extending from a center of the top face, a top of the cylindrical terminal provided with electrical contacts. A left tab and a right tab provided extending from the top face proximate a left end and a right end of the top face, respectively. A peripheral portion of each of the left and the right tabs forming a retaining groove extending from the top face; and an inward facing portion of the peripheral portion of each of the left and the right tabs facing the cylindrical terminal provided with an arc radius centered upon the center of the top face. The battery interconnectable with a range of electronic devices via a range of vectors and/or mechanics. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141285 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/103 (20210101) H01M 50/184 (20210101) H01M 50/209 (20210101) Original (OR) Class H01M 50/247 (20210101) H01M 50/267 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216664 | Wu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Jianfeng Wu (Tucson, Arizona); Karl D. Nelson (Plymouth, Minnesota); Matthew Wade Puckett (Phoenix, Arizona) |
| ABSTRACT | An optical resonator device, which can be implemented in a Brillouin laser, comprises a first waveguide ring resonator having a first diameter, and one or more second waveguide ring resonators adjacent to the first waveguide ring resonator. The one or more second waveguide ring resonators each have a second diameter that is less than the first diameter. The one or more second waveguide ring resonators optically communicate with the first waveguide ring resonator, such that an optical signal in the first waveguide ring resonator optically couples into the one or more second waveguide ring resonators. The one or more second waveguide ring resonators is configured such that when the optical signal resonates within the first waveguide ring resonator and the one or more second waveguide ring resonators, the optical signal within the first waveguide ring resonator is suppressed. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142929 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/30 (20130101) H01S 3/063 (20130101) H01S 3/08018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216667 | KUZNIA et al. |
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| FUNDED BY |
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| APPLICANT(S) | ULTRA COMMUNICATIONS, INC. (Vista, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles B. KUZNIA (Encinitas, California); Vernon Eugene SHRAUGER (Cambridge, Massachusetts); Joseph Farzin AHADIAN (San Marcos, California) |
| ABSTRACT | Methods and systems for an ASIC with a laser with the laser's back-facet illumination being monitored by a photodetector situated such that the substrate of the ASIC acts as a waveguide for the back-facet illumination between the laser and the photodetector (monitor). In an embodiment, the laser and monitor are situated on the same side of the ASIC and the back-facet illumination is reflected off the far end of the ASIC substrate before reaching the monitor. |
| FILED | Saturday, August 29, 2020 |
| APPL NO | 17/006817 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/0014 (20130101) Original (OR) Class H01S 5/021 (20130101) H01S 5/02325 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216784 | Choi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Seungdeog Choi (Starkville, Mississippi); Ashik Amin (Starkville, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seungdeog Choi (Starkville, Mississippi); Ashik Amin (Starkville, Mississippi) |
| ABSTRACT | A mechanism for mitigating electromagnetic interference (EMI) in a network of power converters is disclosed. A controller sends a first control signal to instruct a first power converter to generate a first EMI signal at a first phase. The controller sends a second control signal to instruct a second power converter to generate a second EMI signal at a second phase selected to destructively interfere with the first EMI signal at the first phase. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495585 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/44 (20130101) Original (OR) Class H02M 1/123 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216808 | Kedzierski |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jakub T. Kedzierski (Nashua, New Hampshire) |
| ABSTRACT | An actuator with a stack of thin layers operates by electrowetting droplets between the layers. The actuator includes a first layer structure and a second layer structure positioned adjacent to the first layer structure. One or more liquid droplets are pinned to one of the layers and are positioned between the layers. The other layer includes electrodes. When the electrodes are energized, they electrostatically attract the liquid droplets to create relative motion between the two layers. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/647107 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216936 | Lazzaro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Lazzaro (Churchville, Maryland); William Toth (Ocean, New Jersey) |
| ABSTRACT | Various embodiments are described that relate to random noise addition to a communication. A first secure network can employ a first encryption scheme and a second secure network can employ a second encryption scheme. In order to communicate between the first secure network and the second secure network such that the schemes are not decipherable, random noise can be added to a communication designated to transfer from the first secure network to the second secure network. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/499923 |
| CURRENT CPC | Secret Communication; Jamming of Communication H04K 1/00 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 2209/80 (20130101) Wireless Communication Networks H04W 12/03 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217003 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F Cambou (Flagstaff, Arizona); Fatemeh Afghah (Flagstaff, Arizona); Sareh Assiri (Flagstaff, Arizona); Ashwija Korenda (Flagstaff, Arizona) |
| ABSTRACT | Systems and methods of correcting errors in encrypted communication between a server and client devices using keyless encryption schemes are disclosed. Client devices with arrays of physical-unclonable-function devices respond to challenges from a server. Characteristics of the arrays are stored by the server during a secure enrollment process. To send an encrypted message, the server generates a message digest, extracts data from the stored arrays on the basis of the message digest, applies error correction codes to the message, encrypts the message with the extracted data, and sends the message to a client. The server may receive a handshake containing all or part of the message digest, measures its PUF, and decrypts and decodes the message. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542118 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) H04L 9/3242 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217035 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts) |
| ABSTRACT | A polymorphic platform for wireless communication systems is provided that employs trained classification techniques to determine physical layer parameters from a transmitter at a receiver. The system includes a learning module to determine transmitted physical layer parameters of the signal using a trained classification module, such as a deep learning neural network. The trained classification module receives I/Q input samples from receiver circuitry and processes the I/Q input samples to determine transmitted physical layer parameters from the transmitter. The system includes a polymorphic processing unit that demodulates data from the signal based on the determined transmitted parameters. |
| FILED | Monday, February 24, 2020 |
| APPL NO | 17/604476 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/063 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/34 (20130101) Original (OR) Class H04L 27/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217619 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua W. Robinson (Durham, North Carolina); Joseph M. Carmack (Milford, New Hampshire); Scott A. Kuzdeba (Hollis, New Hampshire); James M. Stankowicz, JR. (Boston, Massachusetts) |
| ABSTRACT | A system whereby individual RF emitter devices are distinguished in real-world environments through deep-learning comprising an RF receiver for receiving RF signals from a plurality of individual devices; a preprocessor configured to produce complex-valued In-phase (I) and Quadrature (Q) IQ signal sample representations; a two-stage Augmented Dilated Causal Convolution (ADCC) network comprising a stack of dilated causal convolution layers and traditional convolutional layers configured to process I and Q components of the complex IQ samples; transfer learning comprising a classifier and a cluster embedding dense layer; unsupervised clustering whereby the RF signals are grouped according to a device that transmitted the RF signal; and an output identifying the individual RF emitter device whereby the individual RF emitter device is distinguished in the real-world environment. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/142800 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Wireless Communication Networks H04W 48/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220211449 | Rentschler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Mark E. Rentschler (Boulder, Colorado); Gregory Formosa (Boulder, Colorado); Joseph M. Prendergast (Boulder, Colorado); Mitchell J. Fulton (Boulder, Colorado) |
| ABSTRACT | Implementations include herein are visual navigation strategies and systems for lumen center tracking comprising a high-level state machine for gross (i.e., left/right/center) region prediction and curvature estimation and multiple state-dependent controllers for center tracking, wall-avoidance and curve following. This structure allows a navigation system to navigate even under the presence of significant occlusion that occurs during turn navigation and to robustly recover from mistakes and disturbances that may occur while attempting to track the lumen center. This system comprises a high-level state machine for gross region prediction, a turn estimator for anticipating sharp turns, and several lower level controllers for heading adjustment. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567665 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/04 (20130101) A61B 1/00006 (20130101) A61B 1/31 (20130101) A61B 5/062 (20130101) A61B 10/04 (20130101) A61B 10/06 (20130101) A61B 34/30 (20160201) Original (OR) Class A61B 2034/301 (20160201) A61B 2034/2065 (20160201) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/66 (20170101) G06T 7/70 (20170101) G06T 2207/10016 (20130101) G06T 2207/10068 (20130101) G06T 2207/20104 (20130101) G06T 2207/20212 (20130101) G06T 2207/30032 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 30/40 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211628 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Jonathan Pokorski (San Diego, California) |
| ABSTRACT | A construct includes a melt processed blend of a biodegradable polymer and viral nanoparticles. The viral nanoparticles are encapsulated within a biodegradable polymer matrix of the biodegradable polymer. The viral nanoparticles include a plurality of immunogenic peptides conjugated to the viral nanoparticles. The construct upon administration to a subject providing sustained release of the viral nanoparticles and conjugated immunogenic peptides from the matrix to the subject. The released viral nanoparticles and conjugated immunogenic peptides eliciting an immunogenic response in the subject. |
| FILED | Friday, February 18, 2022 |
| APPL NO | 17/675605 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) Original (OR) Class A61K 38/00 (20130101) A61K 39/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 11/00 (20130101) C08K 2201/011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211637 | Pagels et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Robert F. Pagels (Princeton, New Jersey); Chester E. Markwalter (Princeton, New Jersey); Justin Gourary (New York, New York); Robert K. Prud'homme (Lawrenceville, New Jersey) |
| ABSTRACT | Disclosed is a process to make nanoparticles highly loaded with water soluble actives, including biologics such as proteins and peptides, which are stabilized by random copolymers. The random copolymers used have all been approved by the FDA for oral formulations. The nanoparticles have a hydrophilic core and a hydrophobic corona and can be further processed through a number of different routes. The process to make these particles is highly scalable and could be used industrially. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 17/609887 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) A61K 9/5192 (20130101) Original (OR) Class A61K 31/711 (20130101) A61K 31/7036 (20130101) A61K 31/7105 (20130101) A61K 38/12 (20130101) A61K 38/14 (20130101) A61K 38/47 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211858 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Honggang Cui (Lutherville, Maryland); Hao Su (Baltimore, Maryland); Feihu Wang (Baltimore, Maryland) |
| ABSTRACT | The present invention provides the design of a class of prodrugs for self-assembly into therapeutic tubular supramolecular polymers and their use in a wide variety of applications. The therapeutic tubular supramolecular polymers can be used to formulate drugs and imaging agents for in vitro and in vivo uses. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/604661 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/4745 (20130101) A61K 47/60 (20170801) A61K 47/645 (20170801) Original (OR) Class A61K 47/6903 (20170801) A61K 47/6907 (20170801) A61K 47/6949 (20170801) A61K 49/0021 (20130101) A61K 49/0039 (20130101) A61K 49/0095 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211881 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Michael Bruckman (Cleveland, Ohio); Lauren Randolph (State College, Pennsylvania) |
| ABSTRACT | An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/108 (20130101) A61K 49/1896 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212194 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Universität Augsburg (Augsburg, Germany) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Universität Augsburg (Augsburg, Germany) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Thomas Franke (Augsburg, Germany); Achim Wixforth (Munich, Germany); Lothar Schmid (Augsburg, Germany); Jeremy Agresti (Cambridge, Massachusetts); Adam R. Abate (Cambridge, Massachusetts) |
| ABSTRACT | Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated front the microfluidic substrate except at or proximate the location where the droplets arc sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550612 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502776 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2300/0816 (20130101) B01L 2400/0421 (20130101) B01L 2400/0436 (20130101) B01L 2400/0487 (20130101) B01L 2400/0496 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 47/04 (20130101) Pipe-line Systems; Pipe-lines F17D 3/01 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2015/1081 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0391 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212918 | HAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alison HAKE (Ann Arbor, Michigan); Karl GROSH (Ann Arbor, Michigan) |
| ABSTRACT | A sensor, such as a piezoelectric MEMS vibration sensor, includes a frame, a beam array comprising a plurality of beams, and a plurality of masses. Each beam of the plurality of beams has an anchored end and an unanchored end, with each beam being coupled to the frame at the anchored end. The unanchored end of each beam is coupled to a respective mass of the plurality of masses. Each beam of the plurality of beams can be configured to minimize a variation in a voltage output for a limited frequency range. In some implementations, the resonant frequency of each beam corresponds to a sensitivity peak in a limited frequency range. |
| FILED | Thursday, May 14, 2020 |
| APPL NO | 17/611541 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) Original (OR) Class B81B 2201/0285 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/0472 (20130101) H01L 41/1132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213153 | HSIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang HSIA (Seattle, Washington); Rubul MOUT (Seattle, Washington); Natasha EDMAN (Seattle, Washington); Ivan VULOVIC (Seattle, Washington); Una NATTERMANN (Seattle, Washington); William H. SHEFFLER (Seattle, Washington); TJ BRUNETTE (Seattle, Washington); Young-Jun PARK (Seattle, Washington); Asim BERA (Seattle, Washington); Matthew BICK (Seattle, Washington); Rachel REDLER (Seattle, Washington); Damian EKIERT (Seattle, Washington); Gira BHABHA (Seattle, Washington); David VEESLER (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213228 | Wei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Alexander Wei (West Lafayette, Indiana); Tae Hoo Chang (West Lafayette, Indiana); Miran Mavlan (Northridge, California) |
| ABSTRACT | The present disclosure generally relates to a process for manufacturing a processable dried cellulose nanomaterial using a co-solvent of tert-butyl alcohol (TBA), of which unique physical/chemical properties enable facile modification/derivatization. This present disclosure also relates to materials and process of generating of superhydrophobic surface coating using hydrophobic carboxylic acid modified cellulose nanofibers. Both the processes and the products thereof are within the scope of this disclosure. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/610584 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Polysaccharides; Derivatives Thereof C08B 1/003 (20130101) Original (OR) Class C08B 3/10 (20130101) C08B 15/005 (20130101) C08B 15/08 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213252 | Langer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Biocant-Center of Innovation and Biotechnology (Cantanhede, Portugal) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Jeffrey M. Karp (Chestnut Hill, Massachusetts); Maria Jose Maio Nunes-Pereira (Lisbon, Portugal); Ben Ouyang (Toronto, Canada); Lino da Silva Ferreira (Coimbra, Portugal); Debanjan Sarkar (Williamsville, New York) |
| ABSTRACT | Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/703 (20130101) A61K 9/7084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/14 (20130101) C08G 18/4236 (20130101) Original (OR) Class C08G 18/4238 (20130101) C08G 18/4283 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213281 | Kingsbury et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Kingsbury (Carrboro, North Carolina); Orlando Coronell (Cary, North Carolina); Maruti Hedge (Carrboro, North Carolina); Jingbo Wang (Los Angeles, California); Wei You (Chapel Hill, North Carolina); Theo Dingemans (Chapel Hill, North Carolina) |
| ABSTRACT | The presently disclosed subject matter generally relates to polymer networks having covalent crosslinks, non-covalent crosslinks, and ionic side groups, and methods of making and using same. Specifically, the disclosed polymer networks can be incorporated into membranes, which can be useful in, for example, electrodialysis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605807 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/18 (20130101) C08F 220/58 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) Original (OR) Class C08J 2333/04 (20130101) C08J 2333/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213459 | Rajan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rakhi Rajan (Norman, Oklahoma) |
| ABSTRACT | Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704317 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/74 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213521 | LUO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan LUO (Ithaca, New York); Shogo HAMADA (Ithaca, New York); Kenneth Gene VANCEY (Ithaca, New York) |
| ABSTRACT | This disclosure relates to generation of dynamic materials having an ordered structure and artificial metabolism. The approach disclosed herein allows autonomous and dynamic generation of materials with structural hierarchy by simultaneously coupling both irreversible synthesis (and optionally decomposition) and dissipative assembly processes, but in an artificial fashion. As an exemplary embodiment, DNA-based Assembly and Synthesis of Hierarchical (or “DASH”) materials have been generated. Systems, devices, reagents and methods for generating the materials, as well as additional applications of the present methodology, are disclosed. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/601561 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2200/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214199 | Dasgupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purnendu K. Dasgupta (Arlington, Ohio); Chuchu Qin (Arlington, Texas) |
| ABSTRACT | A flow meter comprises a capillary, a first and second fluid flow marker, and one or more sensors. The capillary has a longitudinally extending fluid receiving space, with a first end and a second end. The first and second fluid flow markers are immiscible and are positioned in the fluid receiving space. The one or more sensors are positioned along the capillary. A method for measuring flow rates comprises the steps of introducing a first liquid into a flow meter. That first liquid flows into the fluid receiving space at the first end of the capillary thereby displacing the first fluid flow marker and the second fluid flow marker towards the second end of the capillary. The interface between the first fluid flow marker and the second fluid flow marker is measured with one or more sensors to determine the flow rate of the first liquid. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 16/932283 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/7086 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214249 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel, Bldg (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sindy K. Y. Tang (Stanford, California); Nicolas Castaño (Stanford, California); Saisneha Koppaka (Stanford, California); Seth Xordts (Stanford, California) |
| ABSTRACT | A microscale biological tissue cutting device is made of a horizontal array of identically shaped polygonal through holes between vertically-oriented blades which form the sides of the polygonal through holes. Each of the through holes has a width less than 1 mm. The blades are joined at vertices of the polygonal through holes and have vertical peaks at the vertices. The vertical peaks have heights in the range 1-200 μm above a lowest height of a cutting edge of the blades. The blades may be made of a material such as silicon, glass, plastic, resin, or metal. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569775 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/286 (20130101) Original (OR) Class G01N 2001/2873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214274 | Pastrana-Rios |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PROTEIN DYNAMIC SOLUTIONS, INC. (Wakefield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Belinda Pastrana-Rios (Wakefield, Massachusetts) |
| ABSTRACT | The disclosure relates to methods and systems for the analysis of compounds in a crystalline state and/or undergoing crystallization. Two-dimensional correlation (2DCOS) and co-distribution analysis (2DCDS) analysis plots can be generated and analyzed. Asynchronous plots can aid in establishing a sequential order of events. Positive cross peaks that correlate with auto peaks associated with aggregation can be identified. The auto peaks can be referenced to quickly discern the regions of the molecule most perturbed, which would indicate a driver for the crystallization state of the molecule. One can define which functional group types (e.g., region) are most perturbed (positive, intense auto peak) and observe how the different auto peaks begin to have greatest intensity change. These changes in auto peaks in the synchronous plots for the different stages of crystallization can provide information as to the dynamics of the process from amorphous to crystalline state. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553323 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/17 (20130101) G01N 21/35 (20130101) G01N 21/272 (20130101) G01N 21/552 (20130101) G01N 21/3554 (20130101) Original (OR) Class G01N 2021/3595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214304 | ROSENSTEIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob K. ROSENSTEIN (Providence, Rhode Island); Kangping HU (Providence, Rhode Island) |
| ABSTRACT | A complementary metal-oxide-semiconductor sensor array includes an active sensing area of pixels arranged in an array with a pitch, each pixel including an exposed surface electrode alongside switches and logic gates, and non-overlapping clocks configured to rapidly charge and discharge the exposed surface electrode, wherein control signals steer a switched output current between shared column outputs. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497603 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) G01N 27/4148 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 27/2605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214568 | Srinivasan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Srinivasan (Minneapolis, Minnesota); Bethanie Joyce Hills Stadler (Shoreview, Minnesota) |
| ABSTRACT | A method of fabricating a gyrotropic device (e.g., an optical isolator) includes: providing a substrate comprising a waveguide layer and forming an optical isolator active layer on the waveguide layer of the substrate. Forming the optical isolator active layer includes, for a specified composition of the optical isolator active layer, deriving at least one sputtering process parameter, performing sputtering of a plurality of targets according to the at least one sputtering process parameter to deposit the optical isolator active layer on the waveguide layer of the substrate, measuring an initial value of a bias voltage at a first target of the plurality of targets; and throughout deposition of the optical isolator active layer, maintaining the bias voltage at the initial value to within a predetermined threshold of the initial value. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 17/605202 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/1225 (20130101) G02B 6/4208 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0955 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214825 | Ganguly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | Debashis Ganguly (Pittsburgh, Pennsylvania); Rami G. Melhem (Pittsburgh, Pennsylvania); Ziyu Zhang (Pittsburgh, Pennsylvania); Jun Yang (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of managing data during execution of an application for use in a system that includes a host memory, a near memory, and a near device associated with the near memory. The application uses a working set of data that is distributed between the far memory and the near memory. The method includes counting a number of times that the near device accesses a unit of the working set of data from the far memory, determining whether the number of times exceeds a dynamically changing access counter threshold, wherein the dynamically changing access counter threshold is calculated dynamically based on a static threshold that is set for the system, and responsive to determining that the number of times exceeds the dynamically changing access counter threshold, migrating the unit of data from the far memory to the near memory. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/604975 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/061 (20130101) G06F 3/0647 (20130101) G06F 3/0653 (20130101) Original (OR) Class G06F 3/0673 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215068 | Kittur et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aniket Kittur (Pittsburgh, Pennsylvania); Nathan Patrick Hahn (Pittsburgh, Pennsylvania); Joseph Chee Chang (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods of providing a search-ecosystem user interface that assist a user with searching information stored within a computer system and with managing results of the searching. In some embodiments, the methods include providing search-results items in an interactive workspace in which a user can manipulate the search-result items to make review more efficient. In some embodiments, the interactive workspace tracks user interactions with search-result items and visualizes such interaction to the user. In some embodiments, the methods include organizing search results using one or more task cards. In some embodiments, a user can add one or more additional sets of search results to a task card. In some embodiments, a user can share one or more task cards, interactive workspaces, and/or search-results items with one or more other users and allow such other user(s) to interact therewith. Other methods are disclosed, as is software for implementing the methods. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/701936 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/00 (20130101) G06F 16/951 (20190101) G06F 16/9535 (20190101) G06F 16/9537 (20190101) G06F 16/9538 (20190101) G06F 16/9577 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215104 | Mireshghallah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemehsadat Mireshghallah (La Jolla, California); Hadi Esmaeilzadeh (La Jolla, California) |
| ABSTRACT | Methods and systems that provide data privacy for implementing a neural network-based inference are described. A method includes injecting stochasticity into the data to produce perturbed data, wherein the injected stochasticity satisfies an ε-differential privacy criterion and transmitting the perturbed data to a neural network or to a partition of the neural network for inference. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/656409 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/60 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 9/6298 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215115 | Moataz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MongoDB, Inc. (New York, New York) |
| ASSIGNEE(S) | MongoDB, Inc. (New York, New York) |
| INVENTOR(S) | Tarik Moataz (North Providence, Rhode Island) |
| ABSTRACT | Methods and system implement solutions for integrating encryption and emulation into native database formats and/or architectures. “Native” database is used to describe a database that has not been designed for end to end encryption, an off the shelf database deployment, and/or a commercially available database. According to some embodiments, various encryption systems and methods employ emulation operations to enable a native database and native database functions to leverage full encryption primitives. Various aspects integrate emulation operations into standard database implementations, where the emulation enables native database functions to operate on entirely encrypted data. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570730 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/213 (20190101) G06F 21/6227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215284 | JAMIESON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kyle JAMIESON (Princeton, New Jersey); Sai Srikar KASI (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle JAMIESON (Princeton, New Jersey); Sai Srikar KASI (Princeton, New Jersey) |
| ABSTRACT | Systems and methods herein provide for error correction via Low Density Parity Check (LDPC) coding. In one embodiment, a system includes a data buffer operable to receive a block of Low Density Parity Check (LDPC) encoded data. The system also includes a processor operable to reduce a belief propagation algorithm used to encode the LDPC encoded data into a quadratic polynomial, to embed the quadratic polynomial onto a plurality of quantum bits (qubits), and to decode the block of LDPC encoded data via the qubits. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/606962 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/70 (20220101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 13/1154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215969 | LEVIS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IMPACTIVO, LLC (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria LEVIS (San Juan, Puerto Rico) |
| ABSTRACT | Methods and systems for providing health professionals with continued education are based on performance gaps identified from patient data available in transactional systems of record. The methods can include creating a repository of educational material, measuring patient and team level performance gaps, associating the identified performance gaps with appropriate educational material, alerting the person about the appropriate educational material, capturing a user's interaction with the educational materials, and issuing credits or rewards for substantial consumption of the educational materials. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655515 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 70/20 (20180101) Original (OR) Class G16H 80/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216118 | BASOL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Active Layer Parametrics, Inc. (Scotts Valley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bulent Mehmet BASOL (Manhattan Beach, California); Jalal ASHJAEE (Cupertino, California); Abhijeet JOSHI (San Jose, California) |
| ABSTRACT | A method for electrically characterizing a layer disposed on a substrate and electrically insulated from the substrate is disclosed. The method can include forming a test pattern, contacting the test pattern with electrical contact elements at contact regions, and measuring an electrical parameter of the layer by passing a first set of test currents between contact regions. The test pattern can be formed by pushing a pattern forming head against a top surface of the layer, introducing a first fluid into the cavity, and converting the sacrificial portion of the layer into an insulator using the first fluid and forming the test pattern under the test-pattern-shaped inner seal. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/656556 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2644 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/326 (20130101) H01L 21/02318 (20130101) H01L 21/6715 (20130101) H01L 22/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216359 | Chava et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Venkata Surya N. Chava (Columbia, South Carolina); MVS Chandrashekhar (Columbia, South Carolina); Anusha Balachandran (Columbia, South Carolina) |
| ABSTRACT | A voltage tunable solar-blind UV detector using a EG/SiC heterojunction based Schottky emitter bipolar phototransistor with EG grown on p-SiC epi-layer using a chemically accelerated selective etching process of Si using TFS precursor. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/700983 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/109 (20130101) H01L 31/1105 (20130101) Original (OR) Class H01L 31/1816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217003 | Cambou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bertrand F Cambou (Flagstaff, Arizona); Fatemeh Afghah (Flagstaff, Arizona); Sareh Assiri (Flagstaff, Arizona); Ashwija Korenda (Flagstaff, Arizona) |
| ABSTRACT | Systems and methods of correcting errors in encrypted communication between a server and client devices using keyless encryption schemes are disclosed. Client devices with arrays of physical-unclonable-function devices respond to challenges from a server. Characteristics of the arrays are stored by the server during a secure enrollment process. To send an encrypted message, the server generates a message digest, extracts data from the stored arrays on the basis of the message digest, applies error correction codes to the message, encrypts the message with the extracted data, and sends the message to a client. The server may receive a handshake containing all or part of the message digest, measures its PUF, and decrypts and decodes the message. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542118 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) H04L 9/3242 (20130101) H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220211866 | COLEMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew A. COLEMAN (OAKLAND, California); Nicholas O. FISCHER (LIVERMORE, California); Amy RASLEY (LIVERMORE, California); Craig D. BLANCHETTE (SAN LEANDRO, California); Todd PETERSON (CORONADO, California) |
| ABSTRACT | A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561625 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) A61K 39/39 (20130101) A61K 39/0208 (20130101) A61K 47/6915 (20170801) Original (OR) Class A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212158 | Tran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MAAT Energy Company (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim-Chinh Tran (Cambridge, Massachusetts); Leslie Bromberg (Sharon, Massachusetts); Jorj Ian Owen (Dulles, Virginia); Jonathan Whitlow (Melbourne Beach, Florida) |
| ABSTRACT | Chemical production systems which allow for an optimized carbon footprint are presented. Plasma-based reforming systems may provide a viable alternative to standard chemical production techniques, such systems can reduce the carbon footprint of the chemicals produced. Example systems include the production of synthesis gas (syngas), hydrogen, synthetic hydrocarbon fuels, ammonia, and urea. Reducing the carbon footprint of chemicals such as these is of vital importance to reducing the environmental impact of industries such as transportation and agriculture. In many of the embodiments a secondary product is produced, the sale of this secondary product may make the primary low-carbon footprint chemical more economical. In many cases the secondary product is carbon, methods of sequestering this carbon via reverse mining and enhanced oil and gas recovery are presented. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/609063 |
| CURRENT CPC | Separation B01D 53/18 (20130101) B01D 2252/204 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/2445 (20130101) Original (OR) Class B01J 19/2465 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/342 (20130101) C01B 2203/04 (20130101) C01B 2203/062 (20130101) C01B 2203/068 (20130101) C01B 2203/141 (20130101) C01B 2203/148 (20130101) C01B 2203/0233 (20130101) C01B 2203/0283 (20130101) C01B 2203/0861 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/0494 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212363 | Terrani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kurt A. Terrani (Knoxville, Tennessee); Michael P. Trammell (Knoxville, Tennessee); Brian C. Jolly (Knoxville, Tennessee) |
| ABSTRACT | A method for the manufacture of a three-dimensional object using a refractory matrix material is provided. The method includes the additive manufacture of a green body from a powder-based refractory matrix material followed by densification via chemical vapor infiltration (CVI). The refractory matrix material can be a refractory ceramic (e.g., silicon carbide, zirconium carbide, or graphite) or a refractory metal (e.g., molybdenum or tungsten). In one embodiment, the matrix material is deposited according to a binder-jet printing process to produce a green body having a complex geometry. The CVI process increases its density, provides a hermetic seal, and yields an object with mechanical integrity. The residual binder content dissociates and is removed from the green body prior to the start of the CVI process as temperatures increase in the CVI reactor. The CVI process selective deposits a fully dense coating on all internal and external surfaces of the finished object. |
| FILED | Thursday, March 24, 2022 |
| APPL NO | 17/702929 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1007 (20130101) B22F 3/1021 (20130101) B22F 7/02 (20130101) B22F 2301/20 (20130101) B22F 2302/105 (20130101) B22F 2998/10 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/52 (20130101) C04B 35/573 (20130101) C04B 35/5622 (20130101) C04B 2235/77 (20130101) C04B 2235/614 (20130101) Nuclear Reactors G21C 3/324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212414 | KELLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett KELLY (Berkeley, California); Robert Matthew PANAS (Dublin, California); Maxim SHUSTEFF (Piedmont, California); Christopher SPADACCINI (Oakland, California); Hayden TAYLOR (Berkeley, California); Indrasen BHATTACHARYA (Berkeley, California) |
| ABSTRACT | In one aspect the present disclosure relates to a system for forming a three dimensional (3D) object from a volume of photo-responsive material contained within a material container. A plurality of optical projection subsystems are adapted to be arranged at least partially circumferentially around a material container containing the volume of photo-responsive material, and are controlled by a controller. The optical projection subsystems direct optical projections at a plurality of angles θ through the volume of photo-responsive material. The optical projections are further directed about a z axis extending through the volume of photo-responsive material. The plurality of optical subsystems are further controlled by the controller to provide each of the optical projections with a calculated three-dimensional intensity distribution acting over a fixed temporal exposure period, which is sufficient to at least one of cure or remove selected portions of the volume of photo-responsive material, and leave other portions unmodified, to form a desired 3D part. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704072 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) B29C 64/232 (20170801) B29C 64/241 (20170801) B29C 64/245 (20170801) B29C 64/264 (20170801) B29C 64/277 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220212957 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Aaron D. Wilson (Idaho Falls, Idaho); John Lienhard (Lexington, Massachusetts); Akshay Deshmukh (Cambridge, Massachusetts); Zi Hao Foo (Cambridge, Massachusetts) |
| ABSTRACT | A saline feed stream flows into a liquid-liquid extraction system; and a volatile organic solvent flows through a main compressor. The compressed volatile organic solvent then flows through a solvent regenerator, which can be a heat exchanger or a combination of a vaporization device and a condenser, to cool the volatile organic solvent. The cooled volatile organic solvent in liquid phase then flows into the liquid-liquid extraction system, where the saline feed stream contacts the volatile organic solvent to selectively extract water from the saline feed stream into the volatile organic solvent, producing a concentrated brine and an organic-rich mixture of water and the volatile organic solvent. The organic-rich mixture flows from the liquid-liquid extraction system into the solvent regenerator, where the organic-rich mixture is heated to produce an organic-rich vapor and desalinated water; and the organic-rich vapor is recycled as volatile organic solvent back into the liquid-liquid extraction system. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567809 |
| CURRENT CPC | Separation B01D 1/284 (20130101) B01D 5/0003 (20130101) B01D 5/006 (20130101) B01D 11/0488 (20130101) B01D 11/0492 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/04 (20130101) C02F 1/265 (20130101) Original (OR) Class C02F 2101/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213007 | SADOW et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron David SADOW (Ames, Iowa); Uddhav KANBUR (Ames, Iowa) |
| ABSTRACT | Disclosed herein is a process for the conversion of polymers, oligomers, or mixtures thereof into shorter alkanes, carboxylic acids, alcohols, alkyl halides or aldehydes. This process includes contacting the polymers, oligomers, or mixtures thereof with the compound of formula (I): Al(R1)3 (I) where R1 is independently selected at each occurrence thereof from the group consisting of H, aryl, C1-C8 alkyl, and C1-C8 alkoxy, as a reaction mixture, in the presence of a catalyst selected from the group consisting of a transition metal catalyst, a lanthanide series metal catalyst, or combinations thereof. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554666 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/12 (20130101) B01J 31/143 (20130101) B01J 31/1616 (20130101) Acyclic or Carbocyclic Compounds C07C 4/06 (20130101) Original (OR) Class C07C 17/06 (20130101) C07C 29/50 (20130101) C07C 41/01 (20130101) C07C 45/455 (20130101) C07C 51/15 (20130101) C07C 67/24 (20130101) C07C 231/02 (20130101) C07C 2521/12 (20130101) C07C 2531/16 (20130101) C07C 2531/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213153 | HSIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang HSIA (Seattle, Washington); Rubul MOUT (Seattle, Washington); Natasha EDMAN (Seattle, Washington); Ivan VULOVIC (Seattle, Washington); Una NATTERMANN (Seattle, Washington); William H. SHEFFLER (Seattle, Washington); TJ BRUNETTE (Seattle, Washington); Young-Jun PARK (Seattle, Washington); Asim BERA (Seattle, Washington); Matthew BICK (Seattle, Washington); Rachel REDLER (Seattle, Washington); Damian EKIERT (Seattle, Washington); Gira BHABHA (Seattle, Washington); David VEESLER (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/62 (20170801) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213490 | Tuskan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Gerald A. Tuskan (Oak Ridge, Tennessee); Xiaohan Yang (Knoxville, Tennessee); Henrique Cestari De Paoli (Oak Ridge, Tennessee) |
| ABSTRACT | Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid fragments of interest. The cloning system includes two families of destination vectors which can be used in alternating form to systematically combine nucleic acid fragments of interest. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138369 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/64 (20130101) Original (OR) Class C12N 15/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213849 | Wickman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Darin Wickman (Madison, Wisconsin); Sage Lucas Kokjohn (Oregon, Wisconsin) |
| ABSTRACT | A compression ignition engine system allows use of hydrous fuels, in particular hydrous biofuels, with high water content (e.g., 20-85% water). The hydrous fuel is pressurized, and also preferably heated via the engine's exhaust gas, to increase its enthalpy, and is then directly injected into the engine cylinder(s) near top dead center. The system provides brake thermal efficiency increases of 20% or more versus a comparable system using conventional diesel fuel, while allowing the use of inexpensive undistilled or lightly distilled biofuels. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569873 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 7/02 (20130101) F02B 2201/064 (20130101) Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 21/06 (20130101) F02M 21/0206 (20130101) Original (OR) Class F02M 21/0245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214399 | Liaw et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boryann Liaw (Idaho Falls, Idaho); Yulun Zhang (Idaho Falls, Idaho); Qiang Wang (Idaho Falls, Idaho) |
| ABSTRACT | Energy storage cell qualification and related systems, methods, and devices are disclosed. A method of qualifying rechargeable battery cells includes taking measurements on the rechargeable battery cells, determining specific capacity distributions of the rechargeable battery cells as a function of a number of discharge cycles based on the measurements, determining one or more specific capacity thresholds to separate the specific capacity distributions of the rechargeable battery cells into two or more classifications, and qualifying the rechargeable battery cells into the two or more classifications based, at least in part, on the specific capacity distributions and the one or more specific capacity thresholds. A method of implementing rechargeable battery cells into product manufacturing and qualifying the rechargeable battery cells, and deploying those of the rechargeable battery cells qualified into a first classification of the two or more classifications into the product. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149046 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/367 (20190101) Original (OR) Class G01R 31/387 (20190101) G01R 31/3865 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216046 | Cooks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zane Baird (West Lafayette, Indiana); Wen-Ping Peng (Shoufeng, Taiwan) |
| ABSTRACT | The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/148737 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/06 (20130101) H01J 49/10 (20130101) H01J 49/26 (20130101) H01J 49/067 (20130101) Original (OR) Class H01J 49/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216321 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Chen (Naperville, Illinois); Matthew Tirrell (Chicago, Illinois); Hua Zhou (Naperville, Illinois); Le Zhang (Darien, Illinois); Hui Cao (Darien, Illinois); Changjiang Liu (Woodridge, Illinois) |
| ABSTRACT | Redox gating, intrinsically apart from conventional electrolyte gating, combines reversible redox functionalities with common ionic electrolyte moieties to engineer charge transport for power efficient phase control. A colossal sheet carrier density modulation beyond 1016/cm2 as well as up to thousand durable cycling can be reached at the subvolt regime in archetypical functional oxide thin films without unbridled perturbations from ionic defects, which include either cation/anion vacancy or ionic intercalated species like proton. Besides, the redox gating represents a simply and practical way to decouple the electrical and structural phase transitions, improving the device longevity and operation response time. The redox gating works for a wide variety of materials regardless of its crystallinity or crystallographic orientation, including all other functional heterostructures and low-dimensional quantum materials composed of sustainable elements. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/248001 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/51 (20130101) Original (OR) Class H01L 29/7869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216988 | Qi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing Qi (Knoxville, Tennessee); Philip G. Evans (Knoxville, Tennessee); Warren P. Grice (Oak Ridge, Tennessee) |
| ABSTRACT | A passive continuous variable quantum key distribution scheme, where Alice splits the output of a thermal source into two beams, measures one locally and transmits the other mode to Bob after applying attenuation. A secure key can be established based on measurements of the two beams without the use of a random number generator or an optical modulator. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 17/676484 |
| CURRENT CPC | Transmission H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0852 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217071 | ZHENG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gengbin ZHENG (Austin, Texas); Maria GARZARAN (Champaign, Illinois) |
| ABSTRACT | Methods and apparatus for efficient topology-aware tree search algorithm for a broadcast operation. A broadcast tree for a broadcast operation in a network having a hierarchical structure including nodes logically partitioned at group and switch levels. Lists of visited nodes (vnodes) and unvisited nodes (unodes) are initialized. Beginning at a root node, search iterations are performed in a progressive manner to build the tree, wherein a given search iteration finds a unode that can be reached earliest from a vnode, moves the unode that is found from the unode list to the vnode list and adds new unodes to the unode list based on the location of the unode. Beginning with the switch the root node is connected to, the algorithm progressively adds nodes from other switches in the root group and then from other groups and switches within those other groups and continues until all nodes have been visited. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702652 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/18 (20130101) H04L 45/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220217073 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Robert L. Alverson (Seattle, Washington); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods of routing a data communication across a network having a plurality switches are provided by monitoring the operation of the plurality of global links to determine which of the plurality of global links provide working paths. A routing table indicative of a status for the plurality of links is maintained, where the routing table provides weighting for each of the working paths. When routing, a link using a weighted pseudo-random selection from the choices available in the routing table is selected. Routing along one of the working paths commensurate with the selected link is performed, and the weighting is updated based upon the operation of the plurality of links. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594682 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/028 (20130101) Original (OR) Class H04L 45/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220212158 | Tran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MAAT Energy Company (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim-Chinh Tran (Cambridge, Massachusetts); Leslie Bromberg (Sharon, Massachusetts); Jorj Ian Owen (Dulles, Virginia); Jonathan Whitlow (Melbourne Beach, Florida) |
| ABSTRACT | Chemical production systems which allow for an optimized carbon footprint are presented. Plasma-based reforming systems may provide a viable alternative to standard chemical production techniques, such systems can reduce the carbon footprint of the chemicals produced. Example systems include the production of synthesis gas (syngas), hydrogen, synthetic hydrocarbon fuels, ammonia, and urea. Reducing the carbon footprint of chemicals such as these is of vital importance to reducing the environmental impact of industries such as transportation and agriculture. In many of the embodiments a secondary product is produced, the sale of this secondary product may make the primary low-carbon footprint chemical more economical. In many cases the secondary product is carbon, methods of sequestering this carbon via reverse mining and enhanced oil and gas recovery are presented. |
| FILED | Wednesday, May 13, 2020 |
| APPL NO | 17/609063 |
| CURRENT CPC | Separation B01D 53/18 (20130101) B01D 2252/204 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/2445 (20130101) Original (OR) Class B01J 19/2465 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/342 (20130101) C01B 2203/04 (20130101) C01B 2203/062 (20130101) C01B 2203/068 (20130101) C01B 2203/141 (20130101) C01B 2203/148 (20130101) C01B 2203/0233 (20130101) C01B 2203/0283 (20130101) C01B 2203/0861 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/0494 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213480 | PLACE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692630 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213481 | PLACE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | miRecule, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PLACE (Gaithersburg, Maryland); Anthony SALEH (Gaithersburg, Maryland); Tishan WILLIAMS (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/692644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215969 | LEVIS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IMPACTIVO, LLC (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria LEVIS (San Juan, Puerto Rico) |
| ABSTRACT | Methods and systems for providing health professionals with continued education are based on performance gaps identified from patient data available in transactional systems of record. The methods can include creating a repository of educational material, measuring patient and team level performance gaps, associating the identified performance gaps with appropriate educational material, alerting the person about the appropriate educational material, capturing a user's interaction with the educational materials, and issuing credits or rewards for substantial consumption of the educational materials. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655515 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 70/20 (20180101) Original (OR) Class G16H 80/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220216505 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bioenno Tech LLC (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhigang Lin (Santa Ana, California); Chunhu Tan (Santa Ana, California); Tianyu Meng (Santa Ana, California) |
| ABSTRACT | Electrolyte-infiltrated composite electrode includes an electrolyte component consisting of a polymer matrix with ceramic nanoparticles embedded in the matrix to form a networking structure of electrolyte. Suitable ceramic nanoparticles have the basic formula Li7La3Zr2O12 (LLZO) and its derivatives such as AlxLi7-xLa3Zr2-y-zTayNbzO12 where x ranges from 0 to 0.85, y ranges from 0 to 0.50 and z ranges from 0 to 0.75, wherein at least one of x, y and z is not equal to 0. The networking structure of the electrolyte establishes an effective lithium-ion transport pathway in the electrode and strengthens the contact between electrode layer and solid-state electrolyte resulting in higher lithium-ion electrochemical cell's cycling stability and longer battery life. Sold-state electrolytes incorporating the ceramic particles demonstrate improved performance. Large dimensional electrolyte-infiltrated composite electrode sheets can be used in all solid-state lithium electrochemical pouch cells which can be assembled into battery packs. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140690 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/622 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220211351 | Torres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | William M. Torres (Philadelphia, Pennsylvania); Francis G. Spinale (Blythewood, South Carolina); Tarek M. Shazly (Columbia, South Carolina) |
| ABSTRACT | Methods and systems for utilizing myocardial strain imaging in an inverse framework to identify mechanical properties of the heart and to determine structural and functional milestones for the development and progression to heart failure. |
| FILED | Wednesday, March 23, 2022 |
| APPL NO | 17/702067 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/485 (20130101) A61B 8/0883 (20130101) A61B 8/5223 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 17/20 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211700 | Niculescu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Bloomington, Indiana); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Bogdan Niculescu (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/613000 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/202 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220211706 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/277 (20130101) A61K 31/416 (20130101) A61K 31/454 (20130101) A61K 31/498 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 31/713 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/4985 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/241 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220211706 | Habib |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amyn Habib (Dallas, Texas) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/277 (20130101) A61K 31/416 (20130101) A61K 31/454 (20130101) A61K 31/498 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 31/713 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/4985 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/241 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214199 | Dasgupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purnendu K. Dasgupta (Arlington, Ohio); Chuchu Qin (Arlington, Texas) |
| ABSTRACT | A flow meter comprises a capillary, a first and second fluid flow marker, and one or more sensors. The capillary has a longitudinally extending fluid receiving space, with a first end and a second end. The first and second fluid flow markers are immiscible and are positioned in the fluid receiving space. The one or more sensors are positioned along the capillary. A method for measuring flow rates comprises the steps of introducing a first liquid into a flow meter. That first liquid flows into the fluid receiving space at the first end of the capillary thereby displacing the first fluid flow marker and the second fluid flow marker towards the second end of the capillary. The interface between the first fluid flow marker and the second fluid flow marker is measured with one or more sensors to determine the flow rate of the first liquid. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 16/932283 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/7086 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214260 | Bencic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Timothy J. Bencic (Highland Heights, Ohio); David P. Rohler (Shaker Heights, Ohio); Amy F. Fagan (Fairview Park, Ohio); Steven H. Izen (Shaker Heights, Ohio); Arjun K. Maniyedath (Beachwood, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Bencic (Highland Heights, Ohio); David P. Rohler (Shaker Heights, Ohio); Amy F. Fagan (Fairview Park, Ohio); Steven H. Izen (Shaker Heights, Ohio); Arjun K. Maniyedath (Beachwood, Ohio) |
| ABSTRACT | A tomography duct for wind tunnels includes a plurality of light sources and sensors displaced around a support structure. The light sources are cycled and sensor measurements are made from sensors opposite the light sources. Tomographic algorithms are used to determine an extinction map from the sensor measurements. The extinction map provides details about particles in a cross-section of the air flow through the tomography duct. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/693998 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 33/0009 (20130101) G01N 33/0031 (20130101) G01N 33/0036 (20130101) G01N 2015/0046 (20130101) G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220212852 | Lee, SR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Edward Lee, SR. (St. Leonard, Maryland); Ryan M. Luckay (Vienna, Virginia); Robert E. Dixon, JR. (Haymarket, Virginia) |
| ABSTRACT | A device, system, and method for maintaining temperature control of a distribution item, or of the contents of a distribution item, as the distribution item moves through the distribution network. A container housing an item can include a cooling unit, a heating unit, or both, and control circuitry including a temperature sensor. The control circuitry activates the cooling unit or heating unit as required to maintain the item at a desired temperature or within a desired temperature range. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/655970 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 81/18 (20130101) Original (OR) Class B65D 81/3816 (20130101) B65D 81/3823 (20130101) Collection, Production or Use of Heat Not Otherwise Provided for F24V 30/00 (20180501) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 3/06 (20130101) F25D 31/005 (20130101) F25D 2303/082 (20130101) F25D 2303/0843 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220215331 | Klausner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Klausner (Scottsdale, Arizona); Robert E. Dixon, JR. (Haymarket, Virginia) |
| ABSTRACT | Systems described herein for controlling, requesting, and coordinating the creation and generation of labels can be a label broker, providing a centralized location for storing label information created by various entities, and managing the requests for generation of physical labels coming from various sources and entities. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/646194 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) Original (OR) Class G06Q 50/28 (20130101) Ticket-issuing Apparatus; Fare-registering Apparatus; Franking Apparatus G07B 17/00016 (20130101) G07B 17/00314 (20130101) G07B 17/00508 (20130101) G07B 2017/00064 (20130101) G07B 2017/00161 (20130101) G07B 2017/00258 (20130101) G07B 2017/00588 (20130101) Coin-freed or Like Apparatus G07F 17/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220211681 | Mason et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel Mason (Boston, Massachusetts); Xian Wu (Boston, Massachusetts); Jimmy W. Crott (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for preventing and/or reducing the risk of inflammatory disease in subject. In particular, provided herein are methods for preventing colorectal cancer in a subject by administering to the subject one or more curcuminoids and vitamin B6. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/122 (20130101) A61K 31/4415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220214254 | Chun |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Richard K. Chun (Alhambra, California) |
| ABSTRACT | A thermal desorber assembly includes a housing and a desorption heater element mounted in the housing with a sample cavity defined between the desorption heater element and an inner wall of the housing. An outlet port is defined in the housing. A flow channel connects the sample cavity in fluid communication with the outlet port for conveying analytes from the sample cavity to the outlet port for introducing the analytes to a spectrometer. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698229 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) Original (OR) Class G01N 1/2214 (20130101) G01N 1/4022 (20130101) G01N 27/622 (20130101) G01N 2030/008 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/02 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220213464 | CORGIE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Stephane C. CORGIE (Ithaca, New York); Xiaonan DUAN (Ithaca, New York); Emmanuel GIANNELIS (Ithaca, New York); Daniel ANESHANSLEY (Ithaca, New York); Larry P. WALKER (Ithaca, New York) |
| ABSTRACT | A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin, remediation of water contaminated with aromatic substances, polymerizing monomers by a free-radical mechanism, epoxidation of alkenes, halogenation of phenols, inhibiting growth and function of microorganisms in a solution, and carbon dioxide conversion to methanol. Further described are methods for increasing the space time yield and/or total turnover number of a liquid-phase chemical reaction that includes magnetic particles to facilitate the chemical reaction, the method comprising subjecting the chemical reaction to a plurality of magnetic fields of selected magnetic strength, relative position in the chemical reaction, and relative motion. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587006 |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/00 (20130101) B01J 19/12 (20130101) B01J 31/02 (20130101) B01J 31/003 (20130101) B01J 35/04 (20130101) B01J 35/0033 (20130101) B01J 35/1061 (20130101) B01J 37/02 (20130101) B01J 2219/0854 (20130101) B01J 2219/0862 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/484 (20130101) C02F 3/00 (20130101) C02F 3/342 (20130101) C02F 2209/006 (20130101) C02F 2303/04 (20130101) C02F 2305/08 (20130101) Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Heterocyclic Compounds C07D 301/22 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 14/00 (20130101) C08F 18/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 9/0006 (20130101) C12N 9/0061 (20130101) C12N 9/0065 (20130101) C12N 11/04 (20130101) Original (OR) Class C12N 11/08 (20130101) C12N 11/14 (20130101) C12N 11/091 (20200101) C12N 11/098 (20200101) C12N 13/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) C12P 7/22 (20130101) C12P 17/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220217073 | Roweth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Duncan Roweth (Bristol Avon, United Kingdom); Robert L. Alverson (Seattle, Washington); Edwin L. Froese (Burnaby British Columbia, Canada) |
| ABSTRACT | Systems and methods of routing a data communication across a network having a plurality switches are provided by monitoring the operation of the plurality of global links to determine which of the plurality of global links provide working paths. A routing table indicative of a status for the plurality of links is maintained, where the routing table provides weighting for each of the working paths. When routing, a link using a weighted pseudo-random selection from the choices available in the routing table is selected. Routing along one of the working paths commensurate with the selected link is performed, and the weighting is updated based upon the operation of the plurality of links. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594682 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/028 (20130101) Original (OR) Class H04L 45/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220212400 | STROM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Harris Corporation (Melbourne, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BRIAN C. STROM (Melbourne Beach, Florida); CHRISTOPHER A. COREY (Palm Bay, Florida); TIMOTHY F. MCLELLAN (Parrish, Florida); CASEY L. FENDER (Palm Bay, Florida); MURRAY T. HANN (Malabar, Florida) |
| ABSTRACT | A method for making a metal isolator body to be positioned between a heat sensitive component and a heat source includes obtaining at least a thermal conductivity specification and a load specification for the metal isolator body, and generating a metal isolator body design including solid regions and lattice regions to meet at least the thermal conductivity specification and the load specification. Three dimensional (3D) metal printing is used to form the metal isolator body based upon the metal isolator body design. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/656675 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/20 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4882 (20130101) H01L 23/34 (20130101) H01L 23/367 (20130101) H01L 23/3675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220213463 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | KOREA INSTITUTE OF OCEAN SCIENCE and TECHNOLOGY (Busan, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung-Hyun LEE (Busan, South Korea); Jae Kyu LIM (Busan, South Korea); Hyun Sook LEE (Busan, South Korea); Sung Gyun KANG (Busan, South Korea); Kae Kyoung KWON (Busan, South Korea); Yun Jae KIM (Busan, South Korea); Ji-in YANG (Busan, South Korea) |
| ABSTRACT | The present invention relates to an Fe—S fusion protein acting as an electron transport chain, a novel carbon monoxide:formate oxidoreductase (CFOR) including the Fe—S fusion protein, novel Thermococcus strain BCF12 transformed with CFOR, and the use thereof. According to the present invention, two different enzymes may be physically linked directly to each other through the Fe—S fusion protein of the present invention, and thus electrons generated from any one enzyme may be transported directly to another enzyme through the Fe—S cluster of the Fe—S fusion protein. Accordingly, a reaction that produces a target substance with high efficiency by directly supplying electrons necessary for the production of the target substance is possible without leakage of electrons generated in any one enzyme. In addition, the present invention has an advantage in that the overall enzyme reaction rate and yield can be dramatically improved using a new electron transport reaction. Furthermore, it is possible to ensure the stability of each enzyme by allowing the enzymes to exist in a physically fixed state in cells. |
| FILED | Wednesday, November 28, 2018 |
| APPL NO | 17/292967 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0008 (20130101) C12N 9/96 (20130101) Original (OR) Class C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/40 (20130101) Enzymes C12Y 102/01002 (20130101) C12Y 102/02001 (20130101) C12Y 102/07004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220214951 | Fleming et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Patrick Fleming (El Segundo, California); Mustafa Amin (El Segundo, California); James Bynes, III (El Segundo, California); Patrick Llorens (El Segundo, California); Dale D. Kachuche (El Segundo, California); Brian Clebowicz (El Segundo, California); William Rowe (El Segundo, California); Alfredo Lara (El Segundo, California); Neal Pollack (El Segundo, California) |
| ABSTRACT | Fault injection testing for field programmable gate array (FPGA) devices including: interfacing with a FPGA device under test (DUT); imaging a configuration RAM (CRAM) of the FPGA DUT with a first configuration image to define a first operational function of the FPGA DUT where the CRAM includes a plurality of CRAM bits, injecting a plurality of single event upsets into a portion of the plurality of the CRAM bits while the FPGA DUT is operating; concurrently monitoring operations of the FPGA DUT and a reference FPGA device; comparing outputs of the FPGA DUT with outputs of the reference FPGA device during concurrent operations, and if there is a mismatch between the outputs of the FPGA DUT and the reference FPGA, determining that error events have occurred within the FPGA DUT; and storing the error events and CRAM location data associated with corresponding single event upsets in an error log. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141872 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/273 (20130101) Original (OR) Class G06F 11/2268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, July 07, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220707.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page