FedInvent™ Patent Applications
Application Details for Thursday, September 22, 2022
This page was updated on Saturday, September 24, 2022 at 01:54 PM GMT
Department of Health and Human Services (HHS)
| US 20220295841 | MOORE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian W. MOORE (Worcester, Massachusetts); Fatin ALKHALEDI (Worcester, Massachusetts); Alex S. REBELLO (Worcester, Massachusetts); Daniel SOCHACKI (Worcester, Massachusetts); William L. MURPHY (Madison, Wisconsin); Jordan JONES (Worcester, Massachusetts); Glenn GAUDETTE (Wocester, Massachusetts); GIANLUCA FONTANA (Madison, Wisconsin); Masatoshi SUZUKI (Madison, Wisconsin); Katherine Pearl BARTEAU (Madison, Wisconsin); Sin-Ruow TEY (Madison, Wisconsin) |
| ABSTRACT | Use of decellularized plant tissues as scaffolds for producing edible animal tissue are disclosed herein. Particularly, decellularized plant tissues are used as scaffolds for animal cells to allow growth and differentiation it animal tissue. The edible animal tissue can be dried such as in a beef jerky form for human consumption. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/603695 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 13/00 (20160801) Original (OR) Class Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296102 | Eberlin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Livia Schiavinato Eberlin (Austin, Texas); Thomas Milner (Austin, Texas); Jialing Zhang (Austin, Texas); Noah Giese (Austin, Texas); Nitesh Katta (Austin, Texas) |
| ABSTRACT | Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/453740 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/3132 (20130101) A61B 5/0075 (20130101) Original (OR) Class A61B 10/02 (20130101) A61B 17/34 (20130101) A61B 34/30 (20160201) A61B 2090/395 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0026 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4833 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/165 (20130101) H01J 49/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296118 | Bankiewicz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krystof S. Bankiewicz (Oakland, California); Kathryn H. Rosenbluth (San Francisco, California); Adrian P. Kells (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689275 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/1071 (20130101) A61B 5/1072 (20130101) A61B 5/1127 (20130101) A61B 5/6835 (20130101) A61B 6/03 (20130101) A61B 6/04 (20130101) A61B 34/10 (20160201) A61B 90/11 (20160201) A61B 2017/00911 (20130101) A61B 2034/107 (20160201) A61B 2505/05 (20130101) A61B 2576/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296193 | Grupp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins Uniersity (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins Uniersity (Baltimore, Maryland) |
| INVENTOR(S) | Robert Grupp (Baltimore, Maryland); Russell H. Taylore (Severna Park, Maryland); Mehran Armand (Filton, Maryland) |
| ABSTRACT | A method of representing a relative change in position and/or orientation of a bone portion during a surgical procedure according to some embodiments of the invention includes receiving preoperative x-ray computed tomography (CT) images of a bone that will have a portion separated and moved during the surgical procedure. Multiple x-ray images are received, each a different view of the bone during the surgical procedure prior to separating and moving the portion, where the bone has a fiducial marker fixed relative to that portion and another fiducial marker fixed relative to a stationary portion of the bone. The fiducial markers each have at least three radio-opaque points and remain substantially fixed with respect to each other. The position of the radio-opaque points is determined relative to a three-dimensional representation of the bone from the preoperative CT images. After separating and moving the portion, a single x-ray image is received that includes both fiducial markers. The relative change in position and/or orientation is estimated using the single x-ray image. |
| FILED | Friday, September 04, 2020 |
| APPL NO | 17/639546 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/505 (20130101) Original (OR) Class A61B 6/5235 (20130101) A61B 90/37 (20160201) A61B 90/39 (20160201) A61B 2034/105 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296225 | Hendrick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Virtuoso Surgical, Inc. (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hendrick (Nashville, Tennessee); Evan Blum (Nashville, Tennessee); Neal Dillon (Nashville, Tennessee); Trevor Bruns (Clarksville, Tennessee); Stephanie Amack (Nashville, Tennessee); Lauren Branscombe (Nashville, Tennessee) |
| ABSTRACT | A system for performing minimally invasive surgery includes a holding arm, a holding arm interface, an actuation unit detachably disposed on the holding arm interface, and an endoscopic sheath assembly disposed on the holding arm interface opposite the actuation unit. The actuation unit includes a component bay configured to receive a camera, lens and first and second removable and disposable cartridges. Each cartridge includes a concentric tube array extending therefrom, each array including at least one guide tube and a surgical tool disposed inside the guide tube. Numerous safety and communication features are disposed on the various components of the system to ensure failsafe operation and to prevent damage to equipment or harm to patients. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/655477 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) Original (OR) Class A61B 2017/00336 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296374 | Bachus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph A. LONGO (Paradise Valley, Arizona); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kent N. Bachus (Salt Lake City, Utah); Sujee Jeyapalina (Salt Lake City, Utah); James Peter Beck (Salt Lake City, Utah); Roy Bloebaum (Salt Lake City, Utah); Jayant P. Agarwal (Salt Lake City, Utah); Joseph A. Longo (Paradise Valley, Arizona); Erik Kubiak (Salt Lake City, Utah); Brian Mueller Holt (Topanga, California) |
| ABSTRACT | An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717545 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/78 (20130101) A61F 2/2814 (20130101) Original (OR) Class A61F 2002/30784 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296411 | Maier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin Maier (Darien, Connecticut); Meegan Daigler (Portland, Maine); Ariana Sopher (Portland, Maine); Katie Lim (Brooklyn, New York) |
| ABSTRACT | An applicator for inserting a pessary, the applicator including a barrel and a plunger. The barrel having an upper chalice shaped opening having a first diameter at the top most edge and a second diameter at an intermediate location lower than the top most edge. The first diameter is larger than the second diameter. The plunger is configured to at least partially receive a pessary and is telescopically received in the barrel. The plunger is configured and arranged to eject the pessary from the barrel upon telescopic movement of the plunger within the barrel towards the top most edge. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690735 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/005 (20130101) A61F 2/0022 (20130101) A61F 6/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296522 | Castor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ASSIGNEE(S) | Aphios Corporation (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | Embodiments of the present invention are directed to drug delivery systems, dosage forms and methods for the intranasal administration of Bryostatins for the treatment of neuro-degenerative diseases. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down syndrome and Alzheimer's disease. |
| FILED | Sunday, June 27, 2021 |
| APPL NO | 17/359617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/1647 (20130101) Original (OR) Class A61K 9/1682 (20130101) A61K 31/366 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296553 | Nobile et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clarissa J. Nobile (Merced, California); Megha Gulati (Merced, California) |
| ABSTRACT | The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832040 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/133 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/401 (20130101) A61K 31/405 (20130101) A61K 31/661 (20130101) A61K 31/4172 (20130101) A61K 47/08 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296579 | Gudas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Lorraine J. Gudas (New York, New York); Xiao-Han Tang (Staten Island, New York) |
| ABSTRACT | The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia/reperfusion (I/R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RARβ) agonist. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/542852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/426 (20130101) A61K 31/4436 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296583 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen LU (Pearland, Texas); Robert C. BAST, Jr. (Houston, Texas) |
| ABSTRACT | Provided are methods of treating cancer comprising administering to a patient in need thereof a salt-induced kinase 2 (SIK2) inhibitor and at least a first chemotherapeutic drug. Also provided are methods of increasing or enhancing apoptosis of cancer cells in a patient having cancer, comprising administering to the patient a therapeutically effective amount of a SIK2 inhibitor and at least a first chemotherapeutic drug. Also provided are methods of enhancing sensitivity of ovarian cancer cells to a chemotherapeutic drug or to combinations of chemotherapeutic drugs in a patient having ovarian cancer, comprising contacting the cells with a therapeutically effective amount of a SIK2 inhibitor and at least a first chemotherapeutic drug. A method of increasing or enhancing carboplatin-induced DNA damage in a patient having ovarian cancer, comprising administering to the patient a therapeutically effective amount of a SIK2 inhibitor and at least a first chemotherapeutic drug. |
| FILED | Tuesday, January 25, 2022 |
| APPL NO | 17/584116 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/555 (20130101) A61K 31/4545 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296594 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roby Bhattacharyya (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Jason H. Yang (Cambridge, Massachusetts); James J. Collins (Cambridge, Massachusetts); Miguel A. Alcantar (Cambridge, Massachusetts); Roby Bhattacharyya (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions (e.g., pyrimidines) and methods capable of potentiating the effects of antimicrobial agents and/or antiviral agents against bacterial infections and/or viral infections, respectively. Methods of sensitizing bacteria to antimicrobial agents and/or antiviral agents, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at microbial infections and/or viral infections are also provided. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/608919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 31/397 (20130101) A61K 31/505 (20130101) Original (OR) Class A61K 38/1729 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296652 | Russ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Holger A. Russ (Denver, Colorado); Fiona Docherty (Aberdeen, United Kingdom) |
| ABSTRACT | Disclosed herein are methods, systems, and compositions for enhancing the effectiveness of β-cell (Beta-cell)-based therapies. Also disclosed herein are methods, systems, and compositions related to identifying, sorting and separating heterogeneous populations of stem cell-derived pancreatic β-cells (sBCs) into more useful and functionally homogeneous cell populations. In many embodiments, the most mature and functional of the sBCs are identified and live-sorted using the cell surface protein Ectonucleoside Triphosphate Diphosphohydrolase-3 (ENTP3), which is also referred to as CD39L3. The presently disclosed methods, systems, and compositions are useful for cell therapies, for example replacement therapy. In many embodiments the disclosed systems, methods, and compositions are useful in treatments for diabetes. In some embodiments, the disclosed methods, systems, and compositions may be useful in treating, preventing, and/or curing diabetes, for example type-1 diabetes. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0678 (20130101) C12N 2501/16 (20130101) C12N 2501/36 (20130101) C12N 2501/117 (20130101) C12N 2501/335 (20130101) C12N 2506/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296657 | Taneja |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veena Taneja (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to the treatment of a lung condition, such as chronic obstructive pulmonary disease (COPD), using a composition containing live Prevotella (e.g., P. histicola and/or P. melaninogenica), dead (or killed) Prevotella (e.g., P. histicola and/or P. melaninogenica), components of Prevotella (e.g., P. histicola and/or P. melaninogenica), vesicles (e.g., OMVs) of Prevotella (e.g., P. histicola and/or P. melaninogenica), or a combination thereof. For example, methods and materials for using a composition containing live Prevotella (e.g., P. histicola and/or P. melaninogenica), dead (or killed) Prevotella (e.g., P. histicola and/or P. melaninogenica), components of Prevotella (e.g., P. histicola and/or P. melaninogenica), vesicles (e.g., OMVs) of Prevotella (e.g., P. histicola and/or P. melaninogenica), or a combination thereof to treat a lung condition, such as COPD, are provided. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296660 | McFADDEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Grant McFADDEN (Tempe, Arizona); Mohammed Masmudur RAHMAN (Chandler, Arizona) |
| ABSTRACT | Disclosed herein are methods and compositions of treating cancer, comprising administrating to a subject with cancer a therapeutically effective amount of an oncolytic virus and a nucleocytoplasmic transport inhibitor. Further described herein are methods of converting a nonpermissive cancer cell to a permissive cancer cell and methods of killing a cancer cell by contacting the cancer cell with a therapeutically effective amount of an oncolytic vims and a nucleocytoplasmic transport inhibitor. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/639563 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) A61K 31/497 (20130101) A61K 35/768 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296693 | LI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JUN LI (MIAMI, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | JUN LI (MIAMI, Florida) |
| ABSTRACT | The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between α-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, Anopheles gambiae. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296707 | Pravetoni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); HENNEPIN HEALTHCARE RESEARCH INSTITUTE (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Pravetoni (Minneapolis, Minnesota); Carly Baehr (Minneapolis, Minnesota) |
| ABSTRACT | This disclosure describes opioid-specific monoclonal antibodies (mAb), methods of making those antibodies, and methods of using those antibodies. The methods include, for example, treating a subject with an opioid use disorder or neonatal opioid withdrawal syndrome or preventing and reversing opioid overdose in a subject. Additionally or alternatively, the antibodies may be used to detect opioids including, for example, in a screening, diagnostic, or forensic assay. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/616031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39533 (20130101) Original (OR) Class Peptides C07K 16/44 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296736 | Janowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland); The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Miroslaw Janowski (Towson, Maryland); Wojciech Lesniak (Owemgs Mills, Maryland); Poitr Walczak (Fulton, Maryland); Martin G. Pomper (Baltimore, Maryland); Chengyan Chu (Baltimore, Maryland); Anna Jablonska (Baltimore, Maryland) |
| ABSTRACT | Methods are provided for administering and/or assessing a therapeutic agent intraarterially across disrupted blood-brain barrier, systemically or directly to the brain parenchyma in a subject. In a particular aspect, drug infusion parameters can be adjusted based on feedback from real-time MRI and quantitative assessment of brain uptake of the infused therapeutic molecules based on PET imaging. |
| FILED | Tuesday, September 08, 2020 |
| APPL NO | 17/641417 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1093 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296737 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Carolyn Anderson (Columbia, Missouri); Wilson Edwards (Columbia, Missouri); Gary Kohanbash (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein is a method for identifying cytotoxic T cell activity due to cancer immunotherapy in a subject. In some embodiments, the method comprises administering an effective amount of a tracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) to a subject receiving a cancer immunotherapy, wherein the tracer comprises an antibody or antigen-binding fragment thereof that specifically binds to a luminal domain of a lymphocytic granule-associated molecule (LGAM) labeled with a PET or SPECT detectable moiety, and detecting the signal of the tracer by PET or SPECT imaging to identify the cytotoxic T cell activity due to immune therapy for the cancer in the subject. In several embodiments, the antibody or antigen binding fragment specifically binds to the luminal domain of CD107a. |
| FILED | Thursday, March 03, 2022 |
| APPL NO | 17/686230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0474 (20130101) A61K 51/1045 (20130101) A61K 51/1093 (20130101) Original (OR) Class A61K 2121/00 (20130101) Peptides C07K 2317/515 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296776 | Christman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen Christman (San Diego, California); Marianna Alperin (La Jolla, California); Pamela Duran (San Diego, California) |
| ABSTRACT | Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833658 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/58 (20130101) A61L 27/367 (20130101) A61L 27/3633 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2400/06 (20130101) A61L 2430/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296782 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Jue Zhang (Madison, Wisconsin); John Maufort (Madison, Wisconsin) |
| ABSTRACT | Provided herein are human arterial endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human arterial endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/830051 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/07 (20130101) A61F 2/82 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/56 (20130101) A61L 27/507 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 31/146 (20130101) A61L 31/148 (20130101) A61L 2300/42 (20130101) A61L 2300/252 (20130101) A61L 2300/412 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0692 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296845 | Jackson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Nathaniel G. Jackson (Lexington, Massachusetts); Benjamin J. Apollonio (Lunenburg, Massachusetts); Gregory W. Hall (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure provides systems and methods for nitric oxide (NO) generation and/or delivery. In some aspects, a nitric oxide generation system comprises a plasma chamber configured to ionize a reactant gas including nitrogen and oxygen to form a product gas that includes NO, a scrubber downstream from the plasma chamber and having a volume at least partially containing NO2 scrubbing material, and a flow controller downstream of the scrubber configured to control the flow of product gas from the scrubber to a delivery device. A pump is configured to convey product gas from the plasma chamber into the scrubber and is configured to pressurize the product gas in the scrubber when the flow controller is positioned to restrict the flow of product gas from the scrubber. The pressurized product gas accumulates within the scrubber and is at least partially scrubbed of NO2 prior to passage through the flow controller. |
| FILED | Friday, March 11, 2022 |
| APPL NO | 17/693279 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) A61M 16/12 (20130101) Original (OR) Class A61M 16/208 (20130101) A61M 2016/0027 (20130101) A61M 2202/0275 (20130101) A61M 2205/3327 (20130101) A61M 2205/3334 (20130101) Separation B01D 53/1412 (20130101) B01D 53/1456 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/203 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/463 (20210501) H05H 2245/10 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296889 | Badran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bashar Badran (Charleston, South Carolina); Mark S. George (Sullivans Island, South Carolina) |
| ABSTRACT | A system for neurorehabilitation is disclosed that includes a motion detector configured to generate a motion detection feedback signal, a transcutaneous auricular vagus nerve stimulation module, and a controller configured to receive the motion detection feedback signal and send a stimulation signal to the transcutaneous auricular vagus nerve stimulation module based on the motion detection feedback signal meeting a minimum threshold criteria. A method for neurorehabilitation is disclosed that includes the steps of detecting patient motor activity, determining if the detected patient motor activity meets a minimum threshold criteria, and stimulating a vagus nerve through transcutaneous auricular vagus nerve stimulation if the minimum threshold criteria is met. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 17/619950 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/326 (20130101) Original (OR) Class A61N 1/0456 (20130101) A61N 1/36031 (20170801) A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296949 | Shanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vesselin N. Shanov (Cincinnati, Ohio); Soryong Chae (Cincinnati, Ohio); Yanbo Fang (Cincinnati, Ohio); Hyunsik Kim (Cincinnati, Ohio); Yoontaek Oh (Cincinnati, Ohio); Hung Nguyen (Cincinnati, Ohio) |
| ABSTRACT | The present invention relates to a carbon-based material for use in a piece of personal protective equipment and an air filtration system. The carbon-based material may function as a filter by providing a tortuous path for a pathogen to traverse. The carbon-based material may be used as a carbon-based heater that can reach a pathogen inactivation threshold temperature to enable heat inactivation of one or more pathogens. In embodiments where a piece of personal protective equipment includes a carbon-based heater, an insulating layer may be included to attenuate the temperature generated by the carbon-based heater from the face of a user. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655688 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/00 (20130101) A61L 2209/16 (20130101) A61L 2209/21 (20130101) Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 9/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297114 | Berthier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tasso, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erwin Berthier (Seattle, Washington); Ben Casavant (Seattle, Washington); Emily Welch (Seattle, Washington); Joe Himmelheber (Seattle, Washington) |
| ABSTRACT | The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens. |
| FILED | Tuesday, May 24, 2022 |
| APPL NO | 17/752310 |
| CURRENT CPC | Separation B01D 21/262 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50 (20130101) Original (OR) Class B01L 2200/185 (20130101) B01L 2300/023 (20130101) Centrifuges B04B 5/0414 (20130101) B04B 7/02 (20130101) B04B 13/00 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 59/04 (20130101) B65D 77/0426 (20130101) B65D 77/0453 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297116 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peixuan Guo (Dublin, Ohio); Hongran Yin (Dublin, Ohio); Mario Vieweger (Columbus, Ohio) |
| ABSTRACT | Disclosed herein is a system for detecting the presence of a target molecule, such as a target single stranded nucleic acid or polypeptide, in a fluid sample. The system can involve a lateral flow device that includes a porous lateral flow test strip, a solvent reservoir, and an immobilized oligonucleotide that selectively binds to a first portion of the target molecule affixed to the lateral flow test strip at a detection spot or line. The system can further involve a marker oligonucleotide selectively binds a second portion of the target molecule conjugated to a detection reagent. The system can further involve a control oligonucleotide complementary to a portion of the marker oligonucleotide affixed to the lateral flow test strip at a control spot or line. The system can also involve a solvent configured to drag a sample through the lateral flow test strip by capillary forces. |
| FILED | Wednesday, July 08, 2020 |
| APPL NO | 17/625248 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 2300/0636 (20130101) B01L 2300/0825 (20130101) B01L 2400/0406 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) C12Q 1/6834 (20130101) C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297363 | Stoneberg |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sharklet Technologies, Inc. (Aurora, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Eugene Stoneberg (Aurora, Colorado) |
| ABSTRACT | Disclosed herein is a method of forming a bioadhesion resistant article comprising extruding a material through a die bearing a pattern of protrusions such that the extruded material has a surface having a series of parallel splines above a base surface, and applying pressure with a first patterned template to the surface of the extruded material such that the series of parallel raised splines are formed into discrete raised segments of varying length; where the patterned template comprises grooves that are inclined at an angle α to the splines. The method further comprises applying pressure with a second patterned template to the surface of the extruded material, where the second patterned template contains grooves that are inclined at an angle β to the splines. |
| FILED | Friday, June 19, 2020 |
| APPL NO | 17/619330 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/002 (20190201) B29C 48/06 (20190201) B29C 48/0011 (20190201) Original (OR) Class B29C 59/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298103 | Del Poeta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Maurizio Del Poeta (Mount Sinai, New York); Visesato Mor (Kohima, India) |
| ABSTRACT | The present invention provides a compound having the structure: |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724969 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/28 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) A61K 31/166 (20130101) A61K 31/4196 (20130101) A61K 31/7048 (20130101) A61K 31/7072 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 251/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298111 | Gupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arpana Gupta (Los Angeles, California); Tien Dong (Los Angeles, California); Emeran A. Mayer (Los Angeles, California); Jonathan P. Jacobs (Los Angeles, California) |
| ABSTRACT | The present disclosure relates to compounds, compositions and supplements that are capable of treating obesity. The disclosure further relates to methods of treating obesity in a subject in need thereof. |
| FILED | Monday, August 03, 2020 |
| APPL NO | 17/633811 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) A23L 33/135 (20160801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) Heterocyclic Compounds C07D 209/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298162 | CANDIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dynavax Technologies Corporation (Berkeley, California) |
| ASSIGNEE(S) | Dynavax Technologies Corporation (Berkeley, California) |
| INVENTOR(S) | Albert Frederick CANDIA (San Mateo, California); Richard Thomas BERESIS (San Francisco, California); Robert L. COFFMAN (Portola Valley, California) |
| ABSTRACT | The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/664305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 231/56 (20130101) C07D 235/18 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298230 | Ravetch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Jeffrey V. Ravetch (New York, New York); Stylianos Bournazos (New York, New York) |
| ABSTRACT | The present invention provides antibodies that are capable of activating dendritic cell maturation and/or inducing a protective CDS response. The disclosed antibodies can be used to treat or inhibit viral infections, including prophylaxis and treatment of influenza A infection. The invention also provides nucleic acids that encode and immortalized B cells and cultured plasma cells that produce such antibodies. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 17/617901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/1018 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298238 | High et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin Westlund High (Albuquerque, New Mexico); Ravi Venkata Durvasula (Albuquerque, New Mexico); Adinarayana Kunamneni (Albuquerque, New Mexico) |
| ABSTRACT | A composition for treating pain includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. In some embodiments, the receptor is a P2X family receptor such as, for example, P2X4. In some embodiments, the antibody includes a detectable marker. In some of these embodiments, the detectable marker includes a fluorescent tag. The composition may be used to treat acute or chronic pain in a subject. Generally, the methods includes administering to the subject a composition that includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. The non-opioid pain relief composition can reverse pain related mechanical, cold, anxiety-like, and depression-like behaviors in neuropathic pain and chemotoxic nerve injury models. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/637350 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298255 | Gumbiner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Barry M. Gumbiner (Seattle, Washington) |
| ABSTRACT | Provided herein are several monoclonal antibodies that activate the adhesion activity of human and mouse E-cadherin, including the amino acid sequences for the CDRs that define the binding domains of each monoclonal antibody. Also described are methods of making these antibodies, as well as biologically functional fragments and derivatives thereof; and methods of using them in the treatment, prevention, and/or amelioration of disease and conditions characterized by disruption of normal cell adhesion and/or cell junctions. Specifically contemplated are methods and compositions for the treatment of cancer metastasis as well as inflammatory conditions (such as inflammatory bowel disease and airway inflammation). |
| FILED | Friday, May 29, 2020 |
| APPL NO | 17/608886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298261 | Reed |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Translational Sciences Inc. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guy L. Reed (Memphis, Tennessee) |
| ABSTRACT | Compositions and methods of using SerpinF2-binding molecules for preventing and/or reducing organ damage, functional disability or mortality in a patient at risk due to the activity of SerpinF2 and/or plasminogen activators on tissue injury. Also provided are compositions and methods of using SerpinF2-binding molecules for inhibiting hemorrhage, edema, and apoptosis. Methods for the preparation of medicaments for such methods of treatment and prevention are provided. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590744 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298471 | Alsberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Chicago, Illinois); Oju Jeon (Broadview Heights, Ohio) |
| ABSTRACT | A method of forming a gel particle slurry includes providing a first solution that includes a cross-linkable hydrogel polymer macromer and an optional first crosslinker in a first depot and optionally a second solution in a second depot that is separated from the first depot by a mixing unit that includes a mixing element; and reversibly transferring the first solution and the optional second solution through the mixing unit between the first depot and the second depot such that the first solution and the optional second solution are mixed and agitated to form the gel particle slurry. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698539 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) Original (OR) Class C12N 2513/00 (20130101) C12N 2533/74 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298473 | Gerecht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Baltimore, Maryland); Sravanti Kusuma (Baltimore, Maryland) |
| ABSTRACT | Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (EVC) derivation induces endothelial commitment and maturation of pluripotent stem cells. Inhibition of reactive oxygen species generation during the early stages of differentiation abrogates the endothelial inductive effects of the low oxygen environments. Methods of generating various types of cells from pluripotent stem cells (PSCs) are described, as well as compositions and methods of use thereof. In particular, generation of EVCs, bicellular vascular populations, early endothelial cells (ECs) and pericytes via culture in a low oxygen environment is described. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832511 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2501/15 (20130101) C12N 2501/165 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298475 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Wu (New Rochelle, New York); Zilei Liu (San Diego, California); Jie Li (San Diego, California); John Teijaro (San Diego, California) |
| ABSTRACT | The present disclosure provides compositions and methods for monitoring cell to cell (“cell-cell”) interactions in vitro, ex vivo, and in vivo. In some embodiments, the present disclosure provides for the use of these compositions and methods (i) to identify and enrich for tumor-specific antigen (TSA) reactive T cells from tumor infiltrating lymphocytes (TILs) or circulating T cells; (ii) to identify and enrich for T cells that recognize autoantigens in a particular autoimmune disease, and/or (iii) to identify and enrich for antigen specific regulatory T cells that have the potential to be exploited to treat autoimmune disease. In some embodiments, the present disclosure also provides for methods of treating diseases, e.g., cancer with such TSA reactive T cells isolated via the present methods. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616050 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) Original (OR) Class C12N 9/1051 (20130101) C12N 2502/1114 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 204/01152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298487 | WAMHOFF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HemoShear, LLC (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian R. WAMHOFF (Charlottesville, Virginia); Brett R. BLACKMAN (Charlottesville, Virginia); Robert A. FIGLER (Earlysville, Virginia); Daniel G. GIOELI (Charlottesville, Virginia); Michael B. SIMMERS (Charlottesville, Virginia) |
| ABSTRACT | Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240323 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) C12N 5/0693 (20130101) Original (OR) Class C12N 5/0697 (20130101) C12N 2502/28 (20130101) C12N 2502/30 (20130101) C12N 2502/1323 (20130101) C12N 2503/04 (20130101) C12N 2521/00 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298492 | Wimmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eckard Wimmer (East Setauket, New York); Steve Skiena (Setauket, New York); Steffen Mueller (Kings Point, New York); Bruce Futcher (Setauket, New York); Dimitris Papamichail (Newtown, Pennsylvania); John Robert Coleman (Blauvelt, New York); Jeronimo Cello (Port Jefferson, New York) |
| ABSTRACT | This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/13 (20130101) A61K 39/145 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298501 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Han Altae-Tran (Cambridge, Massachusetts); Soumya Kannan (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638355 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298507 | Greenleaf et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California); University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William J. Greenleaf (Stanford, California); Phillip D. Zamore (Stanford, None); Winston R. Becker (Stanford, California); Benjamin Ober-Reynolds (Stanford, California); Karina Jouravleva (Boston, Massachusetts); Samson M. Jolly (Boston, Massachusetts) |
| ABSTRACT | The disclosure provides inhibitory RNA polynucleotides that have partial complementarity to a target gene. The inhibitory RNA polynucleotides have at least one mismatched nucleotide and can be designed to increase or decrease the cleavage rate when loaded onto the RNA-induced silencing complex (RISC). |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 17/616750 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/344 (20130101) C12N 2310/533 (20130101) C12N 2320/10 (20130101) C12N 2330/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298509 | Weiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Deepak Mishra (Cambridge, Massachusetts); Erez Pery (Cambridge, Massachusetts); Wenlong Xu (Cambridge, Massachusetts); Lei Wang (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are sequestrons for detecting an miRNA profile indicative of a cell state and expressing an output molecule in cells having such an miRNA profile. Also provided are methods of using sequestrons provided herein. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701013 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/3519 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298515 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingxiao WANG (San Diego, California); Shu CHIEN (San Diego, California); Yiqian WU (San Diego, California); Shaoying LU (San Diego, California) |
| ABSTRACT | Provided are compositions, products of manufacture, kits and methods for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as T cells in vivo, for activating, adding functions or changing or adding specificities for immune cells, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. Provided are ultrasound-based stimulations and a heat-sensitive activation of proteins caused by the activation of polypeptides controlled by heat shock protein promoters to control the production of intracellular nucleic acid and gene expression, for example, for the expression of biological-active proteins such as T cell receptors, for example, chimeric antigen receptors (CARs). Thermogenetic systems as provided herein can be based on ultrasound and/or heat, allowing a deep penetration of stimulation and manipulation in vivo at centimeter-level depth with high spatiotemporal precision. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/642186 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) C07K 14/7051 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298537 | Littleton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Littleton (Lexington, Kentucky); Barbara Knutson (Lexington, Kentucky); Luke Bradley (Lexington, Kentucky); Stephen Rankin (Lexington, Kentucky); Jan Smalle (Lexington, Kentucky); Jasmina Kurepa (Lexington, Kentucky) |
| ABSTRACT | A method of recovering a product-of-interest from a plant or algal cell and a kit relating to the same are provided. The method of recovering a product-of-interest from a plant or algal cell includes (a) culturing a plant or algal cell that produces a product-of-interest in a culture medium; (b) adding functionalized nanoparticles to the culture medium, whereby the nanoparticles enter the plant or algal cell, bind the product-of-interest, and are extruded into the culture medium; (c) recovering the extruded nanoparticles from the culture medium; and (d) separating the product-of-interest from the extruded nanoparticles. The kit includes a plant or algal cell that produces a product-of-interest when in culture and a functionalized nanoparticle. Also provided is a method of separating plant or algal cells. |
| FILED | Monday, August 31, 2020 |
| APPL NO | 17/638156 |
| CURRENT CPC | Peptides C07K 16/30 (20130101) C07K 2317/13 (20130101) C07K 2317/14 (20130101) C07K 2317/31 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/06 (20130101) C12P 21/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298542 | Stengel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alida Biosciences Inc. (San Diego, California) |
| ASSIGNEE(S) | Alida Biosciences Inc. (San Diego, California) |
| INVENTOR(S) | Gudrun Stengel (San Diego, California); Byron Purse (San Diego, California); Yu-Hsien Hwang-Fu (San Diego, California); Jerome Santos (San Diego, California) |
| ABSTRACT | Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706470 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298543 | Stengel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alida Biosciences Inc. (San Diego, California) |
| ASSIGNEE(S) | Alida Biosciences Inc. (San Diego, California) |
| INVENTOR(S) | Gudrun Stengel (San Diego, California); Byron Purse (San Diego, California); Yu-Hsien Hwang-Fu (San Diego, California); Jerome Santos (San Diego, California) |
| ABSTRACT | Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706493 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298562 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Guo (Tempe, Arizona); Joshua LaBaer (Chandler, Arizona) |
| ABSTRACT | Provided herein are methods for multiplexed in situ analysis of biomolecules in a tissue. In particular, provided herein are methods for multiplexed single-cell in situ protein and nucleic acid profiling in fixed or fresh tissues, that allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal. |
| FILED | Monday, March 14, 2022 |
| APPL NO | 17/694353 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Original (OR) Class C12Q 2563/131 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/582 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298575 | Robins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Adaptive Biotechnologies Corporation (Seattle, Washington); Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harlan S. Robins (Seattle, Washington); Julie Rubinstein (Seattle, Washington); Ryan O. Emerson (Seattle, Washington); Jianda Yuan (New York, New York) |
| ABSTRACT | Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/455651 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298580 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Catherine Wu (Brookline, Massachusetts); Erin Parry (Westwood, Massachusetts) |
| ABSTRACT | The present invention relates to methods for identifying Richter's transformation patients who benefit from PD-1 blockade. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/634465 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299420 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakiand, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Huang (San Francisco, California); Dan Xie (San Francisco, California) |
| ABSTRACT | The present disclosure describes image cytometry methods and systems. One such system comprises an illumination subsystem configured to generate a thin sheet of light; a scanning subsystem configured to move the sheet of light across a threedimensional suspension medium that contains cells or other objects; and an imaging subsystem configured to receive light reflected and/or emitted by the cells/objects. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638657 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/147 (20130101) Original (OR) Class G01N 2015/1006 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299421 | Lo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu-Hwa Lo (San Diego, California); Yuanyuan Han (Milpitas, California) |
| ABSTRACT | Disclosed are methods, devices, systems and applications for camera-less, high-throughput three-dimensional imaging of particles in motion. In some aspects, a system includes a particle motion device to allow particles to move along a travel path; an optical illumination system to produce an asymmetric illumination area of light in a region of the travel path of a particle that scans over a plurality of sections of the particle at multiple time points while the particle is moving; an optical detection system optically interfaced with the particle motion device to obtain optical signal data associated with different parts of the particle corresponding to the particle's volume during motion in the travel path; and a data processing unit to process the optical signal data obtained by the optical detection system and produce data including information indicative of 3D features of the particle. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/805446 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/147 (20130101) G01N 15/1475 (20130101) Original (OR) Class G01N 2015/1006 (20130101) Pictorial Communication, e.g Television H04N 13/254 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299494 | Kaplan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Qiaobing Xu (Lexington, Massachusetts) |
| ABSTRACT | The present disclosure provides a method for screening drug delivery vehicles for use in delivering cargo via oral delivery. The method includes introducing a drug delivery vehicle comprising an imaging agent into a lumen of an artificial intestine system composed of a scaffold matrix material. The scaffold matrix material includes an interconnected network of pores, intestinal epithelial cells positioned on an inner surface of the lumen, and human-based cells positioned within the pores and surrounding the intestinal epithelial cells. The method includes maintaining the artificial intestine system in physiologically relevant conditions for a predetermined length of time, and detecting a color change induced by the imaging agent within at least a portion of the human-based cells. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/753312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/15 (20130101) Original (OR) Class G01N 33/502 (20130101) G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299511 | Reyes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Miguel Reyes (Boston, Massachusetts); Nir Hacohen (Boston, Massachusetts); Paul C. Blainey (Cambridge, Massachusetts); Michael R. Filbin (Boston, Massachusetts); Marcia B. Goldberg (Boston, Massachusetts); Roby P. Bhattacharyya (Boston, Massachusetts) |
| ABSTRACT | Provided herein, in some embodiments, are methods for analyzing immune cells in a blood sample from a subject having, suspected of having, or being at risk for bacterial sepsis. The present disclosure is based, at least in part, on the finding that certain immune cells are expanded in subjects having sepsis compared to healthy subjects. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619958 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) Original (OR) Class G01N 2333/70596 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299513 | Rock et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth L. Rock (Chestnut Hill, Massachusetts); Barry Alan Kriegsman (Holliston, Massachusetts) |
| ABSTRACT | Methods of identifying and treating subjects with immune checkpoint inhibitors and interferon inducers. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 17/608890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/706 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299514 | Barbero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Simone Barbero (Germantown, Maryland); Eli N. Glezer (Del Mar, California); Anu Mathew (North Potomac, Maryland) |
| ABSTRACT | The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen, The invention also relates to assay methods used in connection with the diagnostic methods described herein. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/667714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5377 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/42 (20130101) C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class G01N 2333/912 (20130101) G01N 2333/916 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299522 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hui Zhang (Ellicott City, Maryland); Weiming Yang (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of protein post-translational modification. More specifically, the present invention provides compositions and methods useful for identifying O-linked glycosylation sites in proteins. In one embodiment, the present invention provides a method for identifying O-linked glycosylation sites of Tn antigen in proteins comprising the steps of (a) digesting proteins present in a sample into peptides; (b) enriching for Tn-glycopeptides; (c) conjugating Tn-glycopeptides to solid phase; (d) labeling Tn using the glycosyltransferse enzyme C1GalT1 and a labeled uridine diphosphate galactose (UDP-Gal) substrate to produce labeled Tn-glycopeptides; (e) releasing the labeled Tn-glycopeptides from the solid-phase using an endopeptidase that cleaves peptides at the N-terminus of O-linked glycans at serine or threonine residues; and (f) mapping O-linked glycosylation sites of Tn antigen using liquid chromatography-mass spectrometry. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/638917 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1051 (20130101) C12N 9/6427 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/18 (20130101) C12P 21/005 (20130101) C12P 21/06 (20130101) Enzymes C12Y 204/01 (20130101) C12Y 304/21004 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299523 | AKIYAMA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kawasaki-shi, Japan); NISSHIN SEIFUN GROUP INC. (Chiyoda-ku, Japan) |
| ASSIGNEE(S) | JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (Kawasaki-shi, Japan); NISSHIN SEIFUN GROUP INC. (Chiyoda-ku, Japan) |
| INVENTOR(S) | Hiroshi AKIYAMA (Setagaya-ku, Japan); Hiroyuki KIKUCHI (Kawasaki-shi, Japan); Yusuke SEKI (Fujimino-shi, Japan); Chisato ARIMOTO (Fujimino-shi, Japan) |
| ABSTRACT | A highly sensitive allergen measurement method is provided. A method for detecting an allergen in a sample, comprising: treating a sample with a protease; and detecting presence or absence of an allergen marker in the enzyme-treated sample by analysis that utilizes chromatographic separation. The allergen comprises buckwheat and wheat. |
| FILED | Thursday, July 09, 2020 |
| APPL NO | 17/639226 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/06 (20130101) G01N 30/7233 (20130101) G01N 33/10 (20130101) G01N 33/6848 (20130101) Original (OR) Class G01N 2030/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299527 | BATEMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RANDALL BATEMAN (St. Louis, Missouri); CHIHIRO SATO (St. Louis, Missouri); KANTA HORIE (St Louis, Missouri); NICOLAS BARTHELEMY (St. Louis, Missouri) |
| ABSTRACT | The methods disclosed herein employ unique combinations of processing steps that transform a blood or CSF sample into a sample suitable for quantifying MTBR tau species, as well as other tau species. The present disclosure also encompasses the use of MTBR tau species in blood or CSF to measure pathological features and/or clinical symptoms of 3R- and 4R-tauopathies in order to diagnose, stage, and/or choose treatments appropriate for a given disease stage, and modify a given treatment regimen. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 17/634843 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299530 | SHAPIRO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CONNECTICUT (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linda H. SHAPIRO (Middlebury, Connecticut); Fernando A. FERRER (Sunny Isles Beach, Florida); Charan DEVARAKONDA (Vernon, Connecticut); James J. GRADY (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein are methods and compositions for prognosing or diagnosing an obstructive renal dysfunction or ureteropelvic junction obstruction (UPJO) in a subject, involving detecting in a urine sample from a subject one or more proteins selected from the group consisting of Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR); Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT); Prostaglandin reductase 1 (PTGR1); Vascular cell adhesion protein 1 (VCAM1); and Ficolin-2 (FCN2), or detectable portions thereof to identify the subject as at risk of or having an obstructive renal dysfunction or UPJO. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695381 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 33/54306 (20130101) G01N 2470/06 (20210801) G01N 2800/50 (20130101) G01N 2800/285 (20130101) G01N 2800/385 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299531 | WANNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Ina-Beate WANNER (TOPANGA, California); Joseph A. LOO (ENCINO, California) |
| ABSTRACT | A method for detection or monitoring status of traumatic brain injury (TBI) and/or spinal cord injury (SCI) in a subject is provided. In one embodiment, the method comprises contacting a specimen of bodily fluid obtained from the subject with reagents for assaying for a marker of TBI selected from aldolase C (ALDOC) and brain lipid binding protein (BLBP/FABP7), or a trauma-specific break down product (BDP) of ALDOC or BLBP/FABP7. The method further comprises measuring the amount of marker present in the specimen as compared to a control sample, and determining the presence of TBI or SCI when an elevated amount of marker is present in the specimen compared to the control sample. Optionally, the method further comprises measuring the amount of glutamine synthetase (GS), astrocytic phosphoprotein PEA-15 (PEA15), αB-crystallin (CRYAB/HSP27), a trauma-specific proteolytic cleavage product of ALDOC, GS, PEA15, or CRYAB, or any combination of two or more thereof. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/647289 |
| CURRENT CPC | Enzymes C12Y 201/01259 (20150701) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/6848 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/40 (20130101) G01N 2800/52 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299532 | KAUFMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randal J. KAUFMAN (San Diego, California); Peter ARVAN (Ann Arbor, Michigan) |
| ABSTRACT | The present disclosure relates to proinsulin misfolding in beta cells as it relates to glucose intolerance associated with type 2 diabetes (T2D). |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 17/618112 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/62 (20130101) G01N 2800/042 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299753 | Jian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Yifan Jian (Portland, Oregon); Acner Camino Benech (Portland, Oregon) |
| ABSTRACT | Disclosed are methods and systems for adaptive optics (AO)-optical coherence tomography (OCT) and OCT angiography (OCTA). Embodiments include techniques to generate one or more volumetric and/or depth-resolved figures of merit to guide optimization of ocular aberrations in sensorless AO-OCT and/or AO-OCTA. The one or more figures of merit may be generated in real-time, e.g., in parallel with the OCT scan and/or aberration optimization process. Other embodiments may be described and claimed. |
| FILED | Tuesday, March 08, 2022 |
| APPL NO | 17/689048 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/102 (20130101) A61B 3/1241 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220300769 | Zhou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zongwei Zhou (Tempe, Arizona); Jae Shin (Chandler, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are systems, methods, and apparatuses for actively and continually fine-tuning convolutional neural networks to reduce annotation requirements, in which the trained networks are then utilized in the context of medical imaging. The success of convolutional neural networks (CNNs) in computer vision is largely attributable to the availability of massive annotated datasets, such as ImageNet and Places. However, it is tedious, laborious, and time consuming to create large annotated datasets, and demands costly, specialty-oriented skills. A novel method to naturally integrate active learning and transfer learning (fine-tuning) into a single framework is presented to dramatically reduce annotation cost, starting with a pre-trained CNN to seek “worthy” samples for annotation and gradually enhances the (fine-tuned) CNN via continual fine-tuning. The described method was evaluated using three distinct medical imaging applications, demonstrating that it can reduce annotation efforts by at least half compared with random selection. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698805 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) G06K 9/6262 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30032 (20130101) G06T 2207/30101 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 2201/032 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301172 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leland S. Hu (Phoenix, Arizona); Kristin R. Swanson (Phoenix, Arizona); J. Ross Mitchell (Tampa, Florida); Nhan L. Tran (Peoria, Arizona); Jing Li (Marietta, Georgia); Teresa Wu (Gilbert, Arizona) |
| ABSTRACT | Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/749775 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301563 | Chang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward F. Chang (Oakland, California); David A. Moses (Oakland, California) |
| ABSTRACT | Provided are methods of contextual decoding and/or speech decoding from the brain of a subject. The methods include decoding neural or optical signals from the cortical region of an individual, extracting context-related features and/or speech-related features from the neural or optical signals, and decoding the context-related features and/or speech-related features from the neural or optical signals. Contextual decoding and speech decoding systems and devices for practicing the subject methods are also provided. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 17/626256 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 4/00 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 13/02 (20130101) G10L 15/22 (20130101) G10L 15/24 (20130101) Original (OR) Class G10L 15/142 (20130101) G10L 25/24 (20130101) G10L 25/63 (20130101) G10L 2015/227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301659 | Tang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haixu Tang (Bloominton, Indiana); Kaiyuan Liu (Bloomington, Indiana); Yuzhen Ye (Bloomington, Indiana) |
| ABSTRACT | Method and system for predicting a complete tandem mass spectrum of a molecule are disclosed. For example, the method includes training a prediction model using a dataset with features that incorporate at least one physiochemical feature derived from one or more peptide sequences and predicting complete tandem mass spectra of a molecule using the prediction model, the complete tandem mass spectra including backbone fragment ions and non-backbone fragment ions. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616072 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 40/10 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302324 | GOLDAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York); NEW YORK UNIVERSITY (New York, New York) |
| INVENTOR(S) | Amirhossein GOLDAN (Stony Brook, New York); Wei ZHAO (East Setauket, New York); Ayaskanta SAHU (Brooklyn, New York) |
| ABSTRACT | A photomultiplier containing a solid-state photoconductive film composed of amorphous selenium (a-Se) is provided. In the a-Se containing photomultiplier, a hole-blocking layer is provided that maximizes gain and maintains low dark conductivity. Also, the hole-blocking layer achieves reliable and repeatable impact ionization without irreversible breakdown. The hole-blocking layer is a non-insulating metal oxide having a dielectric constant (k) of greater than 10. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/642471 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/095 (20130101) H01L 31/107 (20130101) H01L 31/0272 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303929 | CHOWDHURY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushik CHOWDHURY (Needham, Massachusetts); Ufuk MUNCUK (Waltham, Massachusetts); Yousof NADERI (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are methods and apparatus for a self-synchronizing software defined radio apparatus wherein the method includes instructing, by a leader module of an RF clock module of the software defined radio apparatus and via a controller module comprising a central coordinator operative to provide a data bridge, a radio frequency (RF) transceiver to transmit a two-tone frequency signal at f1 and f2 over air, separated by a desired input clock frequency, the RF transceiver operative to receive and transmit RF signals, receiving, at a follower module, a transmitted signal, extracting, by the follower module, an envelope of the received signal, and passing the received signal through a filter to obtain a reference clock without modifying existing physical/link layer protocols. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700331 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0033 (20130101) Wireless Communication Networks H04W 56/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220296374 | Bachus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph A. LONGO (Paradise Valley, Arizona); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kent N. Bachus (Salt Lake City, Utah); Sujee Jeyapalina (Salt Lake City, Utah); James Peter Beck (Salt Lake City, Utah); Roy Bloebaum (Salt Lake City, Utah); Jayant P. Agarwal (Salt Lake City, Utah); Joseph A. Longo (Paradise Valley, Arizona); Erik Kubiak (Salt Lake City, Utah); Brian Mueller Holt (Topanga, California) |
| ABSTRACT | An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/717545 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/78 (20130101) A61F 2/2814 (20130101) Original (OR) Class A61F 2002/30784 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296594 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roby Bhattacharyya (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Jason H. Yang (Cambridge, Massachusetts); James J. Collins (Cambridge, Massachusetts); Miguel A. Alcantar (Cambridge, Massachusetts); Roby Bhattacharyya (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions (e.g., pyrimidines) and methods capable of potentiating the effects of antimicrobial agents and/or antiviral agents against bacterial infections and/or viral infections, respectively. Methods of sensitizing bacteria to antimicrobial agents and/or antiviral agents, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at microbial infections and/or viral infections are also provided. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/608919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 31/397 (20130101) A61K 31/505 (20130101) Original (OR) Class A61K 38/1729 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297083 | RASMUSSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth G. RASMUSSEN (Seattle, Washington); John C. KRAMLICH (Seattle, Washington); Igor V. NOVOSSELOV (Seattle, Washington) |
| ABSTRACT | This disclosure relates generally relates to methods and systems useful for continuous synthesis of materials in super-critical carbon dioxide (sCO2). More particularly, this disclosure relates to methods and systems useful for continuous synthesis of coordination polymers, such as metal-organic frameworks (MOFs) and/or covalent organic frameworks (COFs), in sCO2. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/639248 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/008 (20130101) B01J 20/226 (20130101) Original (OR) Class B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/28004 (20130101) B01J 20/28066 (20130101) B01J 20/28071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297100 | Farha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar K. Farha (Glenview, Illinois); Zhijie Chen (Evanston, Illinois); Penghao Li (Evanston, Illinois); J. Fraser Stoddart (Evanston, Illinois) |
| ABSTRACT | A series of isoreticular metal-organic frameworks composed of metal nodes connected by rigid trigonal prismatic organic linkers and having a 6,12-coordinatled alb network topology are provided. Also provided are methods of synthesizing the metal-organic frameworks and methods of using the metal-organic frameworks to catalyze the hydrolysis of organic molecules, such as nerve agents, having hydrolysable bonds. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 17/626791 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1691 (20130101) Original (OR) Class B01J 2531/38 (20130101) B01J 2531/39 (20130101) B01J 2531/48 (20130101) B01J 2531/49 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297190 | Hildreth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen Hildreth (Lakewood, Colorado); Meredith Heilig (Golden, Colorado); Sanaz Yazdanparast (Golden, Colorado); Subbarao Raikar (Golden, Colorado) |
| ABSTRACT | A method is provided to remove a selective amount of material from a metal component fabricated by additive manufacturing in a self-terminating manner. The method can be used to remove support structures and trapped powder from a metal component as well as to smooth surfaces of a 3D printed metal component. In some embodiments, selected surfaces of the metal component are treated to make the selected surfaces at least one of mechanically and chemically unstable. The unstable portion of the metal support can then be removed chemically, electrochemically, or through vapor-phase etching. The method can be used for processing any fluid or vapor-accessible regions and surfaces of a 3D printed metal component. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697814 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/40 (20210101) B22F 10/62 (20210101) Original (OR) Class B22F 10/68 (20210101) B22F 2301/10 (20130101) B22F 2301/15 (20130101) B22F 2301/052 (20130101) B22F 2301/205 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/12 (20130101) C23F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297350 | BAXTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel Universisty (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Joy Rene BAXTER (Havertown, Pennsylvania); Nicolas Javier ALVAREZ (Drexel Hill, Pennsylvania); Giuseppe Rafaello PALMESE (Hainesport, New Jersey) |
| ABSTRACT | The present invention relates to a method for assembling particles having a long axis, a short axis and an average aspect ratio of 10-10,000. The method includes agitating a combination of a first solution, a second solution and the particles in any order to form a mixture wherein one of the first solution and the second solution is in the form of droplets dispersed in the other of the first solution and the second solution and the long axis of the particles is longer than a diameter of the droplets in the mixture, and continuing the agitation until the particles assemble into aggregates of particles with at least 30% of the particles aligned in parallel along the long axis. Aggregate or aggregate composites form by the method are also described. |
| FILED | Friday, August 28, 2020 |
| APPL NO | 17/638145 |
| CURRENT CPC | Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 7/08 (20130101) B29B 7/90 (20130101) Original (OR) Class B29B 13/023 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/12 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2079/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297390 | MAKEEV |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew MAKEEV (Arlington, Texas) |
| ABSTRACT | Disclosed herein are carbon-fiber reinforced polymeric composite and methods related thereto. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 17/606137 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/08 (20130101) Original (OR) Class B29C 70/025 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/10 (20130101) C08J 5/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297808 | Bass |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jamie Bass (Evansville, Indiana) |
| ABSTRACT | Provided is a maritime overboard locator system for use in locating and rescuing a person or asset that has fallen overboard into a body of water. The system includes a locator attached to a person or asset that is activated manually or automatically upon immersion in water. The apparatus emits light, sound, radio, or any combination thereof. The locator is detected by one or more detectors onboard a boat, ship, vessel, or structure. The detectors detect a unique signal that is assigned to each person/asset. Once detected, the detector sends an overboard alert and deploys an unmanned aerial or underwater drone. The drone can include an inflatable life preserver or life raft and a tether cord that helps the person to remain afloat until rescue can be accomplished. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205325 |
| CURRENT CPC | Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 9/01 (20130101) B63C 9/04 (20130101) B63C 9/0005 (20130101) Original (OR) Class B63C 9/26 (20130101) B63C 9/082 (20130101) B63C 2009/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298238 | High et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin Westlund High (Albuquerque, New Mexico); Ravi Venkata Durvasula (Albuquerque, New Mexico); Adinarayana Kunamneni (Albuquerque, New Mexico) |
| ABSTRACT | A composition for treating pain includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. In some embodiments, the receptor is a P2X family receptor such as, for example, P2X4. In some embodiments, the antibody includes a detectable marker. In some of these embodiments, the detectable marker includes a fluorescent tag. The composition may be used to treat acute or chronic pain in a subject. Generally, the methods includes administering to the subject a composition that includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. The non-opioid pain relief composition can reverse pain related mechanical, cold, anxiety-like, and depression-like behaviors in neuropathic pain and chemotoxic nerve injury models. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/637350 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298319 | Catchmark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. Catchmark (State College, Pennsylvania); Ke Liu (University Park, Pennsylvania); Kai Chi (Cedar Grove, New Jersey); Jingxuan Yang (University Park, Pennsylvania) |
| ABSTRACT | An insoluble foam composite material is formed by a mixture combining an anionic polysaccharide, a cationic polysaccharide, a solvent, and a plasticizer. In particular, the composite material can be prepared by heating, freezing and lyophilizing the mixture to produce, for example, insoluble porous foam-like composites. |
| FILED | Wednesday, July 29, 2020 |
| APPL NO | 17/631255 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0061 (20130101) Original (OR) Class C08J 9/228 (20130101) C08J 2303/02 (20130101) C08J 2405/08 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 103/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298324 | Fairbanks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Andrew Fairbanks (Lafayette, Indiana); Allen L Garner (West Lafayette, Indiana) |
| ABSTRACT | A transmission line is disclosed which includes a first conductor, a second conductor, a composite disposed between the first conductor and the second conductor, the composite includes non-linear inclusions comprising one or more of non-linear dielectric and non-linear magnetic inclusions mixed in a matrix material, wherein the non-linear dielectric inclusions are selected from the group consisting of barium strontium titanate (BST), barium titanate, strontium titanate, barium zirconate titanate, lead zirconate titanate, lead titanate, lithium niobate, potassium niobate, lead scandium tantalate, strontium barium niobate, and combinations thereof, and the non-linear magnetic inclusions are selected from the group consisting of nickel zinc ferrite (NZF), manganese zinc ferrite, cobalt ferrite, manganese ferrite, zinc ferrite, nickel ferrite, and combinations thereof, wherein the non-linear inclusions by volume are about 25% NZF, about 10% BST/15% NZF, and about 15% BST/10% NZF, and wherein the first conductor, the second conductor, and the composite form a capacitor. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698014 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Original (OR) Class C08K 2003/2237 (20130101) C08K 2003/2296 (20130101) C08K 2201/001 (20130101) C08K 2201/01 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298572 | WALLACE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cepheid (Sunnyvale, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stacey WALLACE (Stockholm, Sweden); Rebekah Gonzalez BAIG (San Jose, California); Xixi LU (San Jose, California); Rajesh KALDATE (San Jose, California) |
| ABSTRACT | The present disclosure is directed to methods and kits for discriminating between a bacterial infection and viral infection in a human subject. More specifically, the methods can comprise detecting the expression level of a combination of ABL1, IRF9, ITGAM, LY6E, PSTPIP2 and RUNX1 in biological samples from the human subject and determining whether the human subject has a bacterial or viral infection based on those expression levels. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576307 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298582 | KASSIS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut HIll, Massachusetts) |
| ABSTRACT | This invention provides methods of using cell free bodily fluid and blood cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also relates to methods of using cell free bodily fluid and blood cells to identify markers of diseases or conditions. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716329 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298583 | KASSIS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Amin I. KASSIS (Chestnut HIll, Massachusetts) |
| ABSTRACT | This invention provides methods of using cell free bodily fluid and blood cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also relates to methods of using cell free bodily fluid and blood cells to identify markers of diseases or conditions. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716335 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/57484 (20130101) G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298584 | SAWYER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sara L. SAWYER (Boulder, Colorado); Robin DOWELL (Boulder, Colorado); Qing YANG (Longmont, Colorado); Nicholas R. MEYERSON (Broomfield, Colorado) |
| ABSTRACT | The inventive technology includes novel systems, method and compositions for the identification and classification of host-derived RNA biomarkers produced in response to an infection. |
| FILED | Friday, May 13, 2022 |
| APPL NO | 17/744536 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299047 | Mendez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edgar G Mendez (California City, California) |
| ABSTRACT | Combination linear and rotary actuators are disclosed. The linear and rotary actuators have a housing defining a cylindrical interior space and a pair of pistons located inside the cylindrical interior space. An inner bearing cylinder is provided that has spaced-apart ball bearings arranged in a helical pattern on its surface that engage with a structure having an inner surface with helical grooves therein. The structure at least indirectly engages a linear drive piston that is slidably mounted in the housing, and provides rotational movement thereto. The linear drive piston has an input shaft that has ball bearings on its surface, and is inserted inside the output shaft of a revolution piston that has an inner surface with linear grooves. The actuators use hydrostatically charged integral bearing races that activate during operation to reduce friction. Combination linear and rotary actuators with double actuation output shafts are also provided. |
| FILED | Monday, February 28, 2022 |
| APPL NO | 17/681884 |
| CURRENT CPC | Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/14 (20130101) F15B 15/063 (20130101) Original (OR) Class F15B 15/068 (20130101) F15B 2015/1495 (20130101) Gearing F16H 25/2204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299444 | GARG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aditya GARG (Blacksburg, Virginia); Wei ZHOU (Blacksburg, Virginia) |
| ABSTRACT | Methods are provided for making a membrane or textile having a mechanically robust surface-enhanced Raman spectroscopy (SERS) substrate by in a first step adhesively bonding a micropatch array to a substrate, the micropatch array having a plurality of micron-scale pillars, each of the micron-scale pillars in the plurality of micron-scale pillars containing a plurality of plasmonic nanoparticles dispersed within a polymer matrix; and in a subsequent step etching a portion of the polymer matrix to expose at least a portion of the plasmonic nanoparticles at or near a surface of the micron-scale pillars. Membranes and textiles containing the mechanically robust surface-enhanced Raman spectroscopy (SERS) substrates are also provided. |
| FILED | Tuesday, February 22, 2022 |
| APPL NO | 17/677797 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class G01N 2021/656 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299462 | Gupta |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ProbiusDx, Inc. (El Cerrito, California); The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chaitanya Gupta (San Carlos, California) |
| ABSTRACT | A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte. |
| FILED | Monday, March 07, 2022 |
| APPL NO | 17/688329 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/30 (20130101) Original (OR) Class G01N 27/48 (20130101) G01N 27/416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299531 | WANNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Ina-Beate WANNER (TOPANGA, California); Joseph A. LOO (ENCINO, California) |
| ABSTRACT | A method for detection or monitoring status of traumatic brain injury (TBI) and/or spinal cord injury (SCI) in a subject is provided. In one embodiment, the method comprises contacting a specimen of bodily fluid obtained from the subject with reagents for assaying for a marker of TBI selected from aldolase C (ALDOC) and brain lipid binding protein (BLBP/FABP7), or a trauma-specific break down product (BDP) of ALDOC or BLBP/FABP7. The method further comprises measuring the amount of marker present in the specimen as compared to a control sample, and determining the presence of TBI or SCI when an elevated amount of marker is present in the specimen compared to the control sample. Optionally, the method further comprises measuring the amount of glutamine synthetase (GS), astrocytic phosphoprotein PEA-15 (PEA15), αB-crystallin (CRYAB/HSP27), a trauma-specific proteolytic cleavage product of ALDOC, GS, PEA15, or CRYAB, or any combination of two or more thereof. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/647289 |
| CURRENT CPC | Enzymes C12Y 201/01259 (20150701) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/6848 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/40 (20130101) G01N 2800/52 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299592 | Chiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han-Pang Chiu (West Windsor, New Jersey); Abhinav Rajvanshi (Plainsboro, New Jersey); Alex Krasner (Princeton, New Jersey); Mikhail Sizintsev (Princeton, New Jersey); Glenn A. Murray (Jamison, Pennsylvania); Supun Samarasekera (Skillman, New Jersey) |
| ABSTRACT | A method, apparatus and system for determining change in pose of a mobile device include determining from first ranging information received at a first and a second receiver on the mobile device from a stationary node during a first time instance, a distance from the stationary node to the first receiver and the second receiver, determining from second ranging information received at the first receiver and the second receiver from the stationary node during a second time instance, a distance from the stationary node to the first receiver and second receiver, and determining from the determined distances during the first time instance and the second time instance, how far and in which direction the first receiver and the second receiver moved between the first time instance and the second time instance to determine a change in pose of the mobile device, where a position of the stationary node is unknown. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695784 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0036 (20130101) G01S 5/0268 (20130101) Original (OR) Class G01S 13/426 (20130101) G01S 13/865 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299760 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan A. Fan (Palo Alto, California); David Sell (Stanford, California); Jianji Yang (Menlo Park, California) |
| ABSTRACT | Various embodiments are directed to an apparatus and methods of forming and/or using an apparatus comprising a plurality of device components. An example method includes geometrically optimizing a periodic or aperiodic device comprising a plurality of device components by optimizing a topology, for each device component, from a starting point to have particular optical properties for a particular optical response. Each device component includes a plurality of geometric structures. The optimization includes selecting the starting point for a continuous profile to have the particular optical properties for the particular optical response, iteratively converging the continuous profile to a discrete profile, and, while iteratively converging to the discrete profile, adjusting edges between boundaries of the device components by accounting for fabrication constraints. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 16/937258 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/18 (20130101) G02B 27/0012 (20130101) Original (OR) Class G02B 2005/1804 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220300544 | Potter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael Lynn Potter (Fullerton, California); Natalie Lynn Larson (Laguna Beach, California); Amy Cheng (Irvine, California); Hovanes Keseyan (Sherman Oaks, California); Hanh Servin (Yorba Linda, California) |
| ABSTRACT | Disclosed is a natural language processing pipeline that analyzes and processes a corpus of textual data to automatically create a knowledge graph containing the corpus entities such as subjects and object and their relationships such as predicates or verbs. The pipeline is configured as an end-to-end neural Open Schema Construction pipeline having a coreference resolution module, an open information extraction (OIE) module, and an entity canonicalization module. The processed textual data is input to a graph database to create the knowledge graph displayable through a graphical user interface. In operation, the pipeline modules serve to create a single term for all entity mentions in the corpus that reference the same entity through coreference resolution, extract all subject-predicate-object triplets from the coreference resolved corpus through OIE, and then canonicalize the corpus by clustering each entity mention to a canonical form for mapping to the knowledge graph and display. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587401 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/35 (20190101) G06F 16/313 (20190101) G06F 16/3334 (20190101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220300672 | Baker |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Baker (Kaysville, Utah) |
| ABSTRACT | Methods and systems for analyzing and predicting aeroelastic flutter on configurable aircraft are disclosed herein. The method may include the steps of: a) flying a known aircraft type above ground, wherein the aircraft has a payload in a known configuration; b) acquiring data from at least one sensor on the aircraft while flying above ground; c) repeating steps a) and b) with a different payload configuration; d) training a machine learning predictive model for the aircraft type for aeroelastic flutter using the collected data; and e) using the predictive model to predict when aeroelastic flutter may occur on the aircraft type when the aircraft has a payload in a new configuration for which data from sensors was not previously collected with the aircraft in flight. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555850 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/60 (20170101) Electric Digital Data Processing G06F 30/15 (20200101) Original (OR) Class G06F 30/27 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301624 | Whitesides et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Whitesides (Newton, Massachusetts); Michael Johannes Fink (Cambridge, Massachusetts); Albert S. Y. Wong (Cambridge, Massachusetts) |
| ABSTRACT | A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon. Each addressable location is adapted to be physically associated with a collection of k molecules. k is 0 or an integer that is less than or equal to n. n is an integer. The molecules in each collection are selected from a set of n unambiguously identifiable molecules. Each collection is a k-combination out of the set of n molecules. Each collection is uniquely associated with a numerical value having less than or equal to n digits. The presence of the collection indicates the numerical value. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/704607 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 3/006 (20130101) Static Stores G11C 13/0019 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 50/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301688 | Shanechi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHRN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maryam M. Shanechi (Los Angeles, California); Han-Lin Hsieh (Los Angeles, California) |
| ABSTRACT | A method for nonlinear modeling, decoding, and control of neural dynamics includes identifying, based on neural time-series samples, a type of a manifold as a base for a neural model. The method further includes learning, based on a covering space, a dynamic model that is fit on the manifold to create the neural model. The method further includes creating, using the neural model, a geometric decoder and a geometric controller. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/639564 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301805 | Mohammadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Saeed Mohammadi (Zionsville, Indiana); Shabnam Ghotbi (Lafayette, Indiana) |
| ABSTRACT | A field emitter array (FEA) vacuum transistor is disclosed which includes a substrate and a plurality of nanorods formed of a first polarity dopant on the substrate, wherein the dopant density is between about 1013 cm−3 to about 1015 cm−3. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701298 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 21/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302603 | Chieh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as respresented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia-Chi Samuel Chieh (San Diego, California); Everly Yeo (San Diego, California); Randall B. Olsen (Carlsbad, California); Raif Farkouh (San Diego, California); Maxwell M. Kerber (San Diego, California) |
| ABSTRACT | A phased array antenna comprising: a substrate; a plurality of circular polarized wideband antenna elements disposed on the substrate, wherein each element comprises two orthogonal feeds; wherein the plurality of elements are organized into subarrays and physically oriented such that constituent elements of each subarray are sequentially rotated with respect to each other about respective axes that are perpendicular to a surface of the substrate so as to allow RHCP and LHCP transmission and reception; a phase shifter communicatively coupled to the feeds of all the elements and configured to electronically any dynamically compensate for phase regression or progression introduced by the sequential rotation of the elements without relying on physical transmission lines of different dimensions, and further configured to introduce a progressive phase shift across a beam steering plane to enable beam steering of the phased array antenna. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207305 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 21/0006 (20130101) H01Q 21/245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303009 | BOROSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Don M. BOROSON (Needham, Massachusetts); Bryan S. ROBINSON (Arlington, Massachusetts); Jade WANG (Arlington, Massachusetts); Kathleen M. RIESING (Cambridge, Massachusetts); Jamie W. BURNSIDE (Lexington, Massachusetts); Curt Schieler (Acton, Massachusetts); Bryan C. Bilyeu (Wilmington, Massachusetts); Jessica CHANG (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don M. BOROSON (Needham, Massachusetts); Bryan S. ROBINSON (Arlington, Massachusetts); Jade WANG (Arlington, Massachusetts); Kathleen M. RIESING (Cambridge, Massachusetts); Jamie W. BURNSIDE (Lexington, Massachusetts); Curt Schieler (Acton, Massachusetts); Bryan C. Bilyeu (Wilmington, Massachusetts); Jessica CHANG (Cambridge, Massachusetts) |
| ABSTRACT | Communication systems and methods for high-data-rate, high-efficiency, free-space communications are described. High-speed optical modems and automatic repeat request can be employed to transmit large data files without data errors between remote devices, such as an earth-orbiting satellite and ground station. Data rates over 100 Gb/s can be achieved. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578702 |
| CURRENT CPC | Transmission H04B 10/1127 (20130101) Original (OR) Class H04B 10/1129 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303622 | Fleizach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Knowles Fleizach (San Diego, California); Nicholas T. Johnson (Pensacola, Florida); Mohamed Chergui (San Diego, California); Christopher Lichtenberg (Carlsbad, California); Michael P. Civerolo (San Diego, California) |
| ABSTRACT | An apparatus for passive coherent location includes a forecaster, an evaluator, a receiver, and a correlator. The forecaster generates a prediction of a radio-frequency signal transmitted from an antenna of a broadcasting service. The evaluator generates an effectiveness metric from the prediction of the radio-frequency signal. The receiver receives the radio-frequency signal that an object reflects from the antenna to the receiver. The correlator determines, from the radio-frequency signal reflected from the object as received at the receiver, an ambiguity function having a maximum at a temporal offset and a Doppler shift. The temporal offset and the Doppler shift at the maximum partially determine at least a position of the object. The apparatus optionally includes a selector for tuning the receiver to the radio-frequency signal in response to the effectiveness metric. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207402 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/003 (20130101) G01S 13/58 (20130101) G01S 13/86 (20130101) Pictorial Communication, e.g Television H04N 21/458 (20130101) Original (OR) Class H04N 21/466 (20130101) H04N 21/6125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303929 | CHOWDHURY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushik CHOWDHURY (Needham, Massachusetts); Ufuk MUNCUK (Waltham, Massachusetts); Yousof NADERI (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are methods and apparatus for a self-synchronizing software defined radio apparatus wherein the method includes instructing, by a leader module of an RF clock module of the software defined radio apparatus and via a controller module comprising a central coordinator operative to provide a data bridge, a radio frequency (RF) transceiver to transmit a two-tone frequency signal at f1 and f2 over air, separated by a desired input clock frequency, the RF transceiver operative to receive and transmit RF signals, receiving, at a follower module, a transmitted signal, extracting, by the follower module, an envelope of the received signal, and passing the received signal through a filter to obtain a reference clock without modifying existing physical/link layer protocols. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700331 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0033 (20130101) Wireless Communication Networks H04W 56/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220295841 | MOORE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian W. MOORE (Worcester, Massachusetts); Fatin ALKHALEDI (Worcester, Massachusetts); Alex S. REBELLO (Worcester, Massachusetts); Daniel SOCHACKI (Worcester, Massachusetts); William L. MURPHY (Madison, Wisconsin); Jordan JONES (Worcester, Massachusetts); Glenn GAUDETTE (Wocester, Massachusetts); GIANLUCA FONTANA (Madison, Wisconsin); Masatoshi SUZUKI (Madison, Wisconsin); Katherine Pearl BARTEAU (Madison, Wisconsin); Sin-Ruow TEY (Madison, Wisconsin) |
| ABSTRACT | Use of decellularized plant tissues as scaffolds for producing edible animal tissue are disclosed herein. Particularly, decellularized plant tissues are used as scaffolds for animal cells to allow growth and differentiation it animal tissue. The edible animal tissue can be dried such as in a beef jerky form for human consumption. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/603695 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 13/00 (20160801) Original (OR) Class Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296516 | Ahmad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DNAlite Therapeutics, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mubhij Ahmad (Walnut Creek, California); Timothy Day (Oakland, California); Ismail Hafez (Concord, California); John Merritt (San Mateo, California) |
| ABSTRACT | Provided are delivery vehicles, and methods of making and using same for reaching epithelial cells, such as cells within mucus-containing environments, and delivery vehicles with improved stability in harsh environments, including in the gastrointestinal tract. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 17/619036 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5184 (20130101) A61K 47/24 (20130101) A61K 47/6909 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296594 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roby Bhattacharyya (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Jason H. Yang (Cambridge, Massachusetts); James J. Collins (Cambridge, Massachusetts); Miguel A. Alcantar (Cambridge, Massachusetts); Roby Bhattacharyya (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions (e.g., pyrimidines) and methods capable of potentiating the effects of antimicrobial agents and/or antiviral agents against bacterial infections and/or viral infections, respectively. Methods of sensitizing bacteria to antimicrobial agents and/or antiviral agents, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at microbial infections and/or viral infections are also provided. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 17/608919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 31/397 (20130101) A61K 31/505 (20130101) Original (OR) Class A61K 38/1729 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296693 | LI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JUN LI (MIAMI, Florida) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | JUN LI (MIAMI, Florida) |
| ABSTRACT | The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between α-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, Anopheles gambiae. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826617 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296786 | SUN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SpotLESS Materials Inc. (State College, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nan SUN (State College, Pennsylvania); Birgitt BOSCHITSCH (State College, Pennsylvania); Tak-Sing WONG (State College, Pennsylvania) |
| ABSTRACT | Formulations for preparing repellent coatings on surfaces of substrates, such as medical devices, can include a non-cyclic volatile siloxane solvent such as a linear or a branched volatile alkyl (e.g., methyl) siloxane solvent and mixtures thereof. Such formulations include (i) one or more reactive components that can form a bonded layer on a surface in which the bonded layer comprises an array of compounds having one end bound to a surface and an opposite end extending away from the surface; (ii) an acid catalyst; and (iii) the non-cyclic volatile siloxane solvent. The formulation can also include (iv) a lubricant. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697248 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 28/0034 (20130101) Original (OR) Class A61L 28/0069 (20130101) A61L 2400/10 (20130101) A61L 2420/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/00 (20130101) C09D 7/63 (20180101) C09D 183/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296943 | SETHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEN Nozzles Inc. (Castro Valley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunny SETHI (Castro Valley, California); Nicholas J. MCKIBBEN (Oakland, California); Sagar BHATIA (Union City, California) |
| ABSTRACT | In embodiments, an adjustable nozzle includes a nozzle body having an inlet section with an inlet opening, an outlet section with an outlet opening, and a fluid flow path extending from the inlet opening to the outlet opening; an adjustable spray restrictor segment located in the outlet section; and an actuator that displaces the adjustable spray restrictor segment toward and away from a center of the fluid flow path, thereby varying an effective width of the outlet opening to vary a pattern of fluid flowing from the fluid flow path through the outlet opening. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828093 |
| CURRENT CPC | Fire-fighting A62C 31/03 (20130101) Original (OR) Class Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/06 (20130101) B05B 1/12 (20130101) B05B 1/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220296949 | Shanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vesselin N. Shanov (Cincinnati, Ohio); Soryong Chae (Cincinnati, Ohio); Yanbo Fang (Cincinnati, Ohio); Hyunsik Kim (Cincinnati, Ohio); Yoontaek Oh (Cincinnati, Ohio); Hung Nguyen (Cincinnati, Ohio) |
| ABSTRACT | The present invention relates to a carbon-based material for use in a piece of personal protective equipment and an air filtration system. The carbon-based material may function as a filter by providing a tortuous path for a pathogen to traverse. The carbon-based material may be used as a carbon-based heater that can reach a pathogen inactivation threshold temperature to enable heat inactivation of one or more pathogens. In embodiments where a piece of personal protective equipment includes a carbon-based heater, an insulating layer may be included to attenuate the temperature generated by the carbon-based heater from the face of a user. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/655688 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/00 (20130101) A61L 2209/16 (20130101) A61L 2209/21 (20130101) Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 9/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297078 | Pozzo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lilo D. Pozzo (Seattle, Washington); Ryan Kastilani (Seattle, Washington); Brittany P. Bishop (Seattle, Washington); David Shicheng Li (Seattle, Washington) |
| ABSTRACT | Sonochemical synthesis methods of particles (e.g., nanoparticles, microparticles, quantum dots) in emulsion reaction mixtures are described herein. The methods allow for control of the bulk temperature of the reaction mixtures to minimize the effects of solvent temperature increases. The sonochemical synthesis methods (e.g., in emulsion reaction mixtures) offer efficient, accelerated, and controllable pathways towards the on-demand synthesis of complex materials. |
| FILED | Thursday, August 06, 2020 |
| APPL NO | 17/633890 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/06 (20130101) B01J 19/10 (20130101) Original (OR) Class B01J 2219/0888 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/02 (20130101) C01P 2004/62 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297083 | RASMUSSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth G. RASMUSSEN (Seattle, Washington); John C. KRAMLICH (Seattle, Washington); Igor V. NOVOSSELOV (Seattle, Washington) |
| ABSTRACT | This disclosure relates generally relates to methods and systems useful for continuous synthesis of materials in super-critical carbon dioxide (sCO2). More particularly, this disclosure relates to methods and systems useful for continuous synthesis of coordination polymers, such as metal-organic frameworks (MOFs) and/or covalent organic frameworks (COFs), in sCO2. |
| FILED | Thursday, August 27, 2020 |
| APPL NO | 17/639248 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/008 (20130101) B01J 20/226 (20130101) Original (OR) Class B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/28004 (20130101) B01J 20/28066 (20130101) B01J 20/28071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297138 | SETHI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEN Nozzles Inc. (Castro Valley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunny SETHI (Castro Valley, California) |
| ABSTRACT | A smooth bore nozzle includes an inlet section having planar converging inlet side walls and top and bottom walls forming an unobstructed rectangular inlet section fluid passageway; a straight section having planar side walls and top and bottom walls contiguous with the inlet side walls and top and bottom walls forming an unobstructed rectangular straight section fluid passageway; and an outlet section having planar converging outlet top and bottom walls and diverging outlet side walls contiguous with the straight section side walls and top and bottom walls, and an unobstructed rectangular outlet section fluid passageway; wherein the cross-sectional area of the fluid passageway remains constant or decreases in a downstream direction, and a perimeter of the cross section increases along a length of the inlet section, and a perimeter of a cross section of the rectangular outlet section fluid passageway decreases along a length of the outlet section. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828087 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/06 (20130101) Original (OR) Class B05B 1/044 (20130101) B05B 1/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297175 | TAKATA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. TAKATA (Denver, Colorado); Eric D. SMITH (Denver, Colorado); Loren Daniel BRIDGERS (Golden, Colorado); Daniel AINGE (Boulder, Colorado); Alexander H. SLOCUM (Bow, New Hampshire) |
| ABSTRACT | A control system for forming a tapered structure includes a sensor providing feedback for a machine for forming a tapered structure including at least three rolls having at least one bend roll and at least two guide rolls. The guide rolls may include rollette banks having a plurality of rollettes. The machine may also include an adjustment mechanism to position at least one of the rolls, where a diameter of the tapered structure being formed is controlled by relative positions of the rolls. The machine may also include a joining element to join edges of a stock of material together as it is rolled through the rolls to form the tapered structure. The control system may also include a controller to receive feedback from the sensor and to send a control signal based on the feedback to the adjustment mechanism for positioning at least one of the rolls. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825210 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/126 (20130101) B21C 37/128 (20130101) B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/0325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297190 | Hildreth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen Hildreth (Lakewood, Colorado); Meredith Heilig (Golden, Colorado); Sanaz Yazdanparast (Golden, Colorado); Subbarao Raikar (Golden, Colorado) |
| ABSTRACT | A method is provided to remove a selective amount of material from a metal component fabricated by additive manufacturing in a self-terminating manner. The method can be used to remove support structures and trapped powder from a metal component as well as to smooth surfaces of a 3D printed metal component. In some embodiments, selected surfaces of the metal component are treated to make the selected surfaces at least one of mechanically and chemically unstable. The unstable portion of the metal support can then be removed chemically, electrochemically, or through vapor-phase etching. The method can be used for processing any fluid or vapor-accessible regions and surfaces of a 3D printed metal component. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697814 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/40 (20210101) B22F 10/62 (20210101) Original (OR) Class B22F 10/68 (20210101) B22F 2301/10 (20130101) B22F 2301/15 (20130101) B22F 2301/052 (20130101) B22F 2301/205 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/12 (20130101) C23F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297288 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guoqiang Li (Baton Rouge, Louisiana); Sarah Li (Baton Rouge, Louisiana); Jizhou Fan (Baton Rouge, Louisiana); Xiaming Feng (Baton Rouge, Louisiana) |
| ABSTRACT | In one aspect, the disclosure relates to free-standing artificial muscles having a polymeric core encased by an elastic spring. The polymeric core can be any two-way shape memory polymer including, but not limited to, a semicrystalline polymer (polybutadiene polymer, a polycaprolactone polymer, a poly(ethylene-co-vinyl acetate)), a rubber, an ionomer, an elastomer, or a gel. In some aspects, the shape memory polymers are crosslinked. In an alternative aspect, the polymeric core is a twisted and coiled polymeric fiber. In other aspects, the polymeric core is reprocessable, remoldable, and/or recyclable. In one aspect, the elastic spring is metallic, ceramic, plastic, or any combination thereof. The stiffnesses or spring rate of the elastic spring and polymeric core, the two-way shape memory effect of the polymeric core, and their geometrical dimensions can be optimized to maximize the actuation strain based on theoretical principles described herein. Also disclosed are devices incorporating the free-standing artificial muscles. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/655014 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1075 (20130101) Original (OR) Class B25J 9/1085 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/0612 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298075 | Srubar, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Shane Frazier (Broomfield, Colorado); Elizabeth A. Delesky (Boulder, Colorado); Jaqueline D. Wallat-Pullara (Centennial, Colorado) |
| ABSTRACT | Cement paste compositions, concrete compositions, and methods of forming the cement paste compositions and concrete compositions are disclosed. Exemplary cement paste compositions and concrete compositions include a water-soluble additive that is dissolved and is configured to perform one or more of ice recrystallization inhibition and dynamic ice shaping when the cement composition is exposed to temperatures less than or equal to a freezing temperature of water. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619992 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/2629 (20130101) Original (OR) Class C04B 28/02 (20130101) C04B 40/0046 (20130101) C04B 2103/601 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298208 | West et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Korbin Hong James West (Madison, Wisconsin); Helen Elizabeth Blackwell (Middleton, Wisconsin) |
| ABSTRACT | There are provided herein compounds of Formula I, compositions comprising the compounds, and methods for using the compounds. The methods include methods for modulating quorum sensing by Listeria monocytogenes (Lm), methods for reducing the virulence of Lm, methods for inhibiting biofilm formation or growth by Lm on a surface, including food and food processing surfaces, and methods for treating Lm infection in a subject. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701561 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 7/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298321 | Leventis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| INVENTOR(S) | Nicholas Leventis (Rolla, Missouri); Chariklia Sotiriou-Leventis (Rolla, Missouri); Sudhir Mulik (North Wales, Pennsylvania) |
| ABSTRACT | Porous three-dimensional networks of polyurea and porous three-dimensional networks of carbon and methods of their manufacture are described. In an example, polyurea aerogels are prepared by mixing an triisocyanate with water and a triethylamine to form a sol-gel material and supercritically drying the sol-gel material to form the polyurea aerogel. Subjecting the polyurea aerogel to a step of pyrolysis may result in a three dimensional network having a carbon skeleton, yielding a carbon aerogel. The density and morphology of polyurea aerogels can be controlled by varying the amount of isocyanate monomer in the initial reaction mixture. A lower density in the aerogel gives rise to a fibrous morphology, whereas a greater density in the aerogel results in a particulate morphology. Polyurea aerogels described herein may also exhibit a reduced flammability. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515983 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/00 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/18 (20130101) C08G 18/302 (20130101) C08G 18/792 (20130101) C08G 2110/0091 (20210101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/02 (20130101) Original (OR) Class C08J 2205/026 (20130101) C08J 2375/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298473 | Gerecht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sharon Gerecht (Baltimore, Maryland); Sravanti Kusuma (Baltimore, Maryland) |
| ABSTRACT | Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (EVC) derivation induces endothelial commitment and maturation of pluripotent stem cells. Inhibition of reactive oxygen species generation during the early stages of differentiation abrogates the endothelial inductive effects of the low oxygen environments. Methods of generating various types of cells from pluripotent stem cells (PSCs) are described, as well as compositions and methods of use thereof. In particular, generation of EVCs, bicellular vascular populations, early endothelial cells (ECs) and pericytes via culture in a low oxygen environment is described. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832511 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/44 (20130101) A61K 35/545 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2501/15 (20130101) C12N 2501/165 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298492 | Wimmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State of University New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eckard Wimmer (East Setauket, New York); Steve Skiena (Setauket, New York); Steffen Mueller (Kings Point, New York); Bruce Futcher (Setauket, New York); Dimitris Papamichail (Newtown, Pennsylvania); John Robert Coleman (Blauvelt, New York); Jeronimo Cello (Port Jefferson, New York) |
| ABSTRACT | This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/13 (20130101) A61K 39/145 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298509 | Weiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Deepak Mishra (Cambridge, Massachusetts); Erez Pery (Cambridge, Massachusetts); Wenlong Xu (Cambridge, Massachusetts); Lei Wang (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are sequestrons for detecting an miRNA profile indicative of a cell state and expressing an output molecule in cells having such an miRNA profile. Also provided are methods of using sequestrons provided herein. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701013 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/3519 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298650 | VISWANATHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | VENKATASUBRAMANIAN VISWANATHAN (Pittsburgh, Pennsylvania); DILIP KRISHNAMURTHY (Pittsburgh, Pennsylvania); KARTHISH MANTHIRAM (Cambridge, Massachusetts); ZACHARY SCHIFFER (Cambridge, Massachusetts) |
| ABSTRACT | In some aspects, the present disclosure pertains to methods for the electrochemical production of hydrogen in an electrochemical cell comprising an anode, a cathode and a liquid electrolyte comprising an ionic hydrogen carrier, wherein the electrochemical cell is operated under conditions such that hydrogen gas is produced from the ionic hydrogen carrier at the cathode and wherein nitrogen gas is produced from the ionic hydrogen carrier at the anode. Other aspects pertain to devices and systems for carrying out such methods. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/760944 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) Original (OR) Class C25B 9/63 (20210101) C25B 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299525 | Ozcan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Aydogan Ozcan (Los Angeles, California); Hyou-Arm Joung (Los Angeles, California); Zachary S. Ballard (Los Angeles, California); Omai Garner (Los Angeles, California); Dino Di Carlo (Los Angeles, California); Artem Goncharov (Los Angeles, California) |
| ABSTRACT | A system for detecting the presence of and/or quantifying the amount or concentration of one or more analytes in a sample includes a flow assay cartridge having a multiplexed sensing membrane that has immunoreaction or biological reaction spots of varying conditions spatially arranged across the surface of the membrane defining an optimized spot map. A reader device is provided that uses a camera to image the multiplexed sensing membrane. Image processing software obtains normalized pixel intensity values of the plurality of immunoreaction or biological reaction spots and which are used as inputs to one or more trained neural networks configured to generate one or more outputs that: (i) quantify the amount or concentration of the one or more analytes in the sample; and/or (ii) indicate the presence of the one or more analytes in the sample; and/or (ii) determines a diagnostic decision or classification of the sample. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 17/612575 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 33/54387 (20210801) G01N 2333/4737 (20130101) G01N 2800/32 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10064 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301338 | NASRABADI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasser M. NASRABADI (Morgantown, West Virginia); Jeremy M. Dawson (Fairmont, West Virginia); Ali DABOUEI (Morgantown, West Virginia) |
| ABSTRACT | Various examples are provided for distortion rectification and fingerprint crossmatching. In one example, a method includes selecting an electronic, perspective distorted fingerprint sample; and generating an unwarped fingerprint sample by rectifying perspective distortions from the perspective distorted fingerprint sample by application of an unwarping transformation. Parameters of the unwarping transformation can be determined by a deep convolutional neural network (DCNN) trained on a database comprising contactless fingerprint samples suffering from perspective distortions. In another example, a system comprises processing circuitry that can: identify warp parameters associated with a contactless fingerprint sample, the warp parameters estimated from the contactless fingerprint sample by a DCNN trained on a database comprising contactless fingerprint samples suffering from perspective distortions; and generate an unwarped fingerprint sample from the contactless fingerprint sample, the unwarped fingerprint sample generated using an unwarping transformation based upon the identified warp parameters. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 17/616040 |
| CURRENT CPC | Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/772 (20220101) G06V 40/1347 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301805 | Mohammadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Saeed Mohammadi (Zionsville, Indiana); Shabnam Ghotbi (Lafayette, Indiana) |
| ABSTRACT | A field emitter array (FEA) vacuum transistor is disclosed which includes a substrate and a plurality of nanorods formed of a first polarity dopant on the substrate, wherein the dopant density is between about 1013 cm−3 to about 1015 cm−3. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/701298 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 21/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303024 | Melodia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso Melodia (Newton, Massachusetts); Emrecan Demirors (Boston, Massachusetts) |
| ABSTRACT | Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an acoustic medium. The corresponding method or apparatus may include a gate-level digital hardware module communicatively coupled to a communications module and define therein logic blocks configured to perform respective primitive processing functions, sequences of the logic blocks being capable of processing data units in accordance with any of the multiple communications protocols on a data unit-by-data unit basis without reconfiguring. According to some embodiments, the gate-level digital hardware module may be configured to process a data unit in accordance with a first communications protocol by directing the data unit through a first sequence of logic blocks, and process a subsequent data unit in accordance with a second communications protocol by directing the subsequent data unit through a second of sequence logic blocks. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/804905 |
| CURRENT CPC | Transmission H04B 11/00 (20130101) Original (OR) Class H04B 13/02 (20130101) H04B 14/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303487 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gigajot Technology, Inc. (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiaju Ma (Monrovia, California); Saleh Masoodian (Monrovia, California) |
| ABSTRACT | First and second readout circuits, each having a respective floating diffusion node, are coupled to a photodetection element within a pixel of an integrated-circuit image sensor. Following an exposure interval in which photocharge is accumulated within the photodetection element, a first portion of the accumulated photocharge is transferred from the photodetection element to the first floating diffusion node to enable generation of a first output signal within the first readout circuit, and a second portion of the accumulated photocharge is transferred from the photodetection element to the second floating diffusion node to enable generation of a second output signal within the second readout circuit. A digital pixel value is generated based on the first and second output signals. |
| FILED | Friday, April 08, 2022 |
| APPL NO | 17/716176 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/355 (20130101) H04N 5/378 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303929 | CHOWDHURY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushik CHOWDHURY (Needham, Massachusetts); Ufuk MUNCUK (Waltham, Massachusetts); Yousof NADERI (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are methods and apparatus for a self-synchronizing software defined radio apparatus wherein the method includes instructing, by a leader module of an RF clock module of the software defined radio apparatus and via a controller module comprising a central coordinator operative to provide a data bridge, a radio frequency (RF) transceiver to transmit a two-tone frequency signal at f1 and f2 over air, separated by a desired input clock frequency, the RF transceiver operative to receive and transmit RF signals, receiving, at a follower module, a transmitted signal, extracting, by the follower module, an envelope of the received signal, and passing the received signal through a filter to obtain a reference clock without modifying existing physical/link layer protocols. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700331 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0033 (20130101) Wireless Communication Networks H04W 56/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220304160 | Fedder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary K. Fedder (Turtle Creek, Pennsylvania); Rahul Panat (Pittsburgh, Pennsylvania); Jacob Brenneman (Pittsburgh, Pennsylvania); Derya Z. Tansel (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are devices comprising stretchable 3D circuits and methods for fabricating the circuits. The fabrication process includes providing in the elastomeric polymer as a substrate and providing conductive interconnects within the substrate encased in an insulating polymer, such as polyimide, to provide a stiffness gradient between the conductive interconnects and the flexible elastomeric substrate. The circuit may be fabricated as a multilayer construction using three-dimensional pillars as vias and as external interconnects to the circuit. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699446 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0393 (20130101) H05K 3/40 (20130101) H05K 3/0064 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220297174 | Whalen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Vineet V. Joshi (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Jens T. Darsell (West Richland, Washington); Mageshwari Komarasamy (Richland, Washington); Curt A. Lavender (Richland, Washington); Glenn J. Grant (Benton City, Washington); Aashish Rohatgi (Richland, Washington); William E. Frazier, III (Richland, Washington); Brandon Scott Taysom (West Richland, Washington) |
| ABSTRACT | Devices and methods for performing shear-assisted extrusion processes for forming extrusions of a desired composition from a feedstock material are provided. The processes can use a device having a scroll face having an inner diameter portion bounded by an outer diameter portion, and a member extending from the inner diameter portion beyond a surface of the outer diameter portion. Extrusion feedstocks and extrusion processes are provided for forming extrusions of a desired composition from a feedstock. The processes can include providing a feedstock having at least two different materials and engaging the materials with one another within a feedstock container. Methods for preparing metal sheets are provided that can include preparing a metal tube via shear assisted processing and extrusion; opening the metal tube to form a sheet having a first thickness; and rolling the sheet to a second thickness that is less than the first thickness. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/826054 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) Original (OR) Class B21C 23/04 (20130101) B21C 23/218 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297175 | TAKATA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. TAKATA (Denver, Colorado); Eric D. SMITH (Denver, Colorado); Loren Daniel BRIDGERS (Golden, Colorado); Daniel AINGE (Boulder, Colorado); Alexander H. SLOCUM (Bow, New Hampshire) |
| ABSTRACT | A control system for forming a tapered structure includes a sensor providing feedback for a machine for forming a tapered structure including at least three rolls having at least one bend roll and at least two guide rolls. The guide rolls may include rollette banks having a plurality of rollettes. The machine may also include an adjustment mechanism to position at least one of the rolls, where a diameter of the tapered structure being formed is controlled by relative positions of the rolls. The machine may also include a joining element to join edges of a stock of material together as it is rolled through the rolls to form the tapered structure. The control system may also include a controller to receive feedback from the sensor and to send a control signal based on the feedback to the adjustment mechanism for positioning at least one of the rolls. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825210 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/126 (20130101) B21C 37/128 (20130101) B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/0325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297191 | DEMUTH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. DEMUTH (Mountain View, California); Andrew BAYRAMIAN (Manteca, California); Bassem S. EL-DASHER (Livermore, California); Kevin J. KRAMER (Redmond, Washington) |
| ABSTRACT | The present disclosure relates to a system for manufacturing a part via an additive manufacturing process. The system uses a reservoir for containing a heated solution forming a mixture of a volatile component and meltable powdered material particles, the heated solution being heated to a point where the heated solution is at least about to begin boiling. A nozzle associated with the reservoir channels a quantity of the heated solution onto at least one of a substrate or a previously formed material layer. A processor controls a flow of the heated solution through the nozzle onto at least one of the substrate or the previously formed material layer. A heat source responsive to the processor generates heat to melt the powdered material particles. The heat source is controlled to melt the powdered material particles after the volatile component has at least substantially evaporated from the mixture. The volatile component cools a previously formed material layer before heating of the powdered material particles takes place, and the heating of the particles fuses the particles into a single structural layer, thus forming the part exclusively from the particles. |
| FILED | Sunday, May 15, 2022 |
| APPL NO | 17/744721 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/107 (20220101) B22F 10/10 (20210101) B22F 12/00 (20210101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/165 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/25 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298011 | CHRISTENSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven Thomas CHRISTENSEN (Golden, Colorado); Nicholas Allan STRANGE (Campbell, California); Kurt Michael VAN ALLSBURG (Denver, Colorado) |
| ABSTRACT | Described herein are compositions and methods for the chemical storage and release of hydrogen gas. The described compositions may be useful as fuel additives for hydrogen consuming applications, including aviation. The provided compositions are flexible and can be tailored to be lightweight, have high energy capacity, have various methods of activation and rapidly release the stored hydrogen. |
| FILED | Tuesday, March 22, 2022 |
| APPL NO | 17/655901 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/0031 (20130101) Original (OR) Class Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/1266 (20130101) C10L 2200/0277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298073 | Pecha et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Brennan Pecha (Littleton, Colorado); Lori Elizabeth Tunstall (Golden, Colorado); Julia Hylton (Golden, Colorado) |
| ABSTRACT | Described herein are cementitious compositions comprising biochar and methods of making such compositions. The compositions find use in a variety of applications, including use in a variety of building materials and building applications. |
| FILED | Friday, March 18, 2022 |
| APPL NO | 17/698569 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/06 (20130101) C04B 18/068 (20130101) Original (OR) Class C04B 28/04 (20130101) C04B 2103/0039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298169 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chuang Li (Evanston, Illinois); Samuel I. Stupp (Evanston, Illinois) |
| ABSTRACT | Provided herein are sulfonate-based water-soluble photoswitches that, in contrast to existing systems, trigger a volumetric expansion in hydrogels upon exposure to photons; contraction is in turn observed under dark conditions in a highly reversible manner. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697286 |
| CURRENT CPC | Heterocyclic Compounds C07D 491/107 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/1063 (20200201) C08F 2800/10 (20130101) C08F 2810/20 (20130101) C08F 2810/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298361 | AYTUG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tolga AYTUG (Knoxville, Tennessee); John T. SIMPSON (Clinton, Tennessee) |
| ABSTRACT | An article having a nanostructured surface and a method of making the same are described. The article can include a substrate and a nanostructured layer bonded to the substrate. The nanostructured layer can include a plurality of spaced apart nanostructured features comprising a contiguous, protrusive material and the nanostructured features can be sufficiently small that the nanostructured layer is optically transparent. A continuous layer can be adhered to a plurality of surfaces of the nanostructured features to render the plurality of surfaces of the nanostructured features both hydrophobic and oleophobic with respect to fingerprint oil comprising eccrine secretions and sebaceous secretions, thereby providing an anti-fingerprinting characteristic to the article. |
| FILED | Monday, April 04, 2022 |
| APPL NO | 17/712939 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/002 (20130101) C03C 17/02 (20130101) C03C 17/34 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/00 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/10 (20130101) C23C 14/58 (20130101) C23C 14/5806 (20130101) C23C 14/5873 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24355 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298362 | Zalich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Zalich (Wexford, Pennsylvania); Paul H. Berdahl (Walnut Creek, California); Stuart D. Hellring (Pittsburgh, Pennsylvania) |
| ABSTRACT | A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment or dye different from the infrared reflective pigment. A multi-layer coating including the coating composition, and a substrate at least partially coated with the coating composition is also disclosed. A method of detecting an article at least partially coated with the coating composition is also disclosed. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825623 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/063 (20130101) B05D 7/52 (20130101) B05D 7/546 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/004 (20130101) Original (OR) Class C09D 5/22 (20130101) C09D 7/62 (20180101) C09D 127/16 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/06 (20130101) C09K 11/55 (20130101) C09K 11/58 (20130101) C09K 11/59 (20130101) C09K 11/592 (20130101) C09K 11/685 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298459 | Zheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoyu Zheng (Pleasanton, California); Joshua R. Deotte (Livermore, California) |
| ABSTRACT | A functionally graded material is formed by pipetting individual micro-or-nano-litter droplets with a variety of materials including multi-nanostructured material (nanowires, carbon nanotubes, enzymes, multi-element and/or multi-color, multi-biomolecules) and UV polymerization of the flat hydrogel meniscus surface formed at the carrier fluid interface. After step-by-step droplet pipetting and subsequent layer-by-layer UV polymerization via a digital mask, the complete fabricated part without supporting layers is taken out of the carrier fluid while the un-cured micro-litter residue is conveniently suctioned out of the carrier fluid. |
| FILED | Friday, April 15, 2022 |
| APPL NO | 17/659403 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/135 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 25/14 (20130101) C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298615 | Ohodnicki, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paul Richard Ohodnicki, JR. (Allison Park, Pennsylvania); Alex Leary (Cleveland, Ohio); Randy R. Bowman (Valley City, Ohio); Ronald D. Noebe (Medina, Ohio); Grant E. Feichter (Massillon, Ohio); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Richard Ohodnicki, Jr. (Allison Park, Pennsylvania); Alex Leary (Cleveland, Ohio); Randy R. Bowman (Valley City, Ohio); Ronald D. Noebe (Medina, Ohio); Grant E. Feichter (Massillon, Ohio); Michael Edward McHenry (Pittsburgh, Pennsylvania); Kevin Byerly (Pittsburgh, Pennsylvania); Vladimir Keylin (Cleveland, Ohio) |
| ABSTRACT | A method of modifying a domain structure of a magnetic ribbon is provided. The method includes a combination of stress and magnetic field annealing the magnetic ribbon in order to generate a desired permeability along one or more axes of the magnetic ribbon. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/626626 |
| CURRENT CPC | Alloys C22C 19/07 (20130101) C22C 2202/02 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/10 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 41/02 (20130101) Dynamo-electric Machines H02K 15/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298622 | Oliver |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. Oliver (Rochester, New York) |
| ABSTRACT | Striated composite layers are deposited using reactive electron-beam evaporation of hafnium dioxide and silicon dioxide sublayers in a planetary rotation or linear translation system in which the hafnia and silica vapor plumes are present at the same time, and yet the hafnia and silica sublayers are distinct. The resulting StriCom materials exhibit significant improvements in laser-induced damage thresholds, thin-film stresses, environmental sensitivity, and control of refractive indices relative to monolayer hafnia films. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/695476 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/30 (20130101) Original (OR) Class C23C 14/083 (20130101) C23C 14/505 (20130101) Optical Elements, Systems, or Apparatus G02B 5/281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298626 | KANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donghyeon KANG (Willowbrook, Illinois); Jeffrey W. ELAM (Elmhurst, Illinois); Joseph A. LIBERA (Clarendon Hills, Illinois); Yujia LIANG (Lisle, Illinois); HackSung KIM (Naperville, Illinois); Anil U. MANE (Naperville, Illinois) |
| ABSTRACT | A process for forming a lithium-metal-oxygen film on a lithium SSE. A metal-ligand complex is exposed to the SSE such as for 30-600 seconds in a chemical vapor transfer reactor at a temperature of 200-350° C. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207445 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/18 (20130101) Original (OR) Class C23C 16/455 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299242 | FARAMARZI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramin Teimouri FARAMARZI (Pacific Palisades, California); Sammy HOUSSAINY (Mission Viejo, California); Jason David WOODS (Boulder, Colorado); Eric KOZUBAL (Superior, Colorado) |
| ABSTRACT | The present disclosure relates to an improved open vertical display case (OVDC) which utilizes radiant cooling to cool and/or maintain food products at a target temperature. The radiant cooling is performed using a plurality of piping routed through the walls and containing a first refrigerant stream. The plurality of piping may be cooled using a refrigeration circuit. In some embodiments, a phase change material may be used for thermal energy storage and positioned between the plurality of piping and the refrigeration circuit. In some embodiments, the refrigeration circuit may be connected to heating ventilation and air conditioning (HVAC) systems and water heating systems within the building. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697126 |
| CURRENT CPC | Special Furniture, Fittings, or Accessories for Shops, Storehouses, Bars, Restaurants or the Like; Paying Counters A47F 3/0443 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 1/00 (20130101) F25B 23/003 (20130101) Original (OR) Class F25B 2400/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299575 | Gering |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin L. Gering (Idaho Falls, Idaho) |
| ABSTRACT | Embodiments disclosed herein include a device including a lithium-ion battery and a battery-management system. The battery-management system may be configured to measure charge states of the lithium-ion battery over a number of charging cycles at specified conditions. The battery-management system may also be configured to obtain an expression for lithium-metal-deposition (LMD)-based capacity fade. The battery-management system may also be configured to determine an LMD state of the lithium-ion battery responsive to a comparison between the measured charge states and the expression. Related devices and systems are also disclosed herein. Additional embodiments are directed to methods, systems, and/or devices configured to generate an expression for LMD-based capacity fade. |
| FILED | Tuesday, March 15, 2022 |
| APPL NO | 17/654931 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/378 (20190101) G01R 31/392 (20190101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/005 (20200101) H02J 7/00712 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299985 | SEREBRYAKOV et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SERGEY SEREBRYAKOV (Milpitas, California); TAHIR CADER (Liberty Lake, Washington); DEEPAK NANJUNDAIAH (Bangalore, India) |
| ABSTRACT | Multi-metric artificial intelligence (AI)/machine learning (ML) models for detection of anomalous behavior of a machine/system are disclosed. The multi-metric AI/ML models are configured to detect anomalous behavior of systems having multiple sensors that measure correlated sensor metrics such as coolant distribution units (CDUs). The multi-metric AI/ML models perform the anomalous system behavior detection in a manner that enables both a reduction in the amount of sensor instrumentation needed to monitor the system's operational behavior as well as a corresponding reduction in the complexity of the firmware that controls the sensor instrumentation. As such, AI-enabled systems and corresponding methods for anomalous behavior detection disclosed herein offer a technical solution to the technical problem of increased failure rates of existing multi-sensor systems, which is caused by the presence of redundant sensor instrumentation that necessitates complex firmware for controlling the sensor instrumentation. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207540 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 23/024 (20130101) G05B 23/0235 (20130101) Original (OR) Class G05B 23/0262 (20130101) G05B 23/0297 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301241 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyojin Kim (Davis, California); Rushil Anirudh (Dublin, California); Kyle Champley (Pleasanton, California); Kadri Aditya Mohan (Newark, California); Albert William Reed (Los Lunas, New Mexico); Suren Jayasuriya (Tempe, Arizona) |
| ABSTRACT | A system for generating a 4D representation of a scene in motion given a sinogram collected from the scene while in motion. The system generates, based on scene parameters, an initial 3D representation of the scene indicating linear attenuation coefficients (LACs) of voxels of the scene. The system generates, based on motion parameters, a 4D motion field indicating motion of the scene. The system generates, based on the initial 3D representation and the 4D motion field, a 4D representation of the scene that is a sequence of 3D representations having LACs. The system generates a synthesized sinogram of the scene from the generated 4D representation. The system adjusts the scene parameters and the motion parameters based on differences between the collected sinogram and the synthesized sinogram. The processing is repeated until the differences satisfy a termination criterion. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208849 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/207 (20170101) G06T 11/008 (20130101) Original (OR) Class G06T 15/08 (20130101) G06T 2207/20084 (20130101) G06T 2207/30181 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301291 | Martinez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carianne Martinez (Albuquerque, New Mexico); Kevin Matthew Potter (Albuquerque, New Mexico); Emily Donahue (Albuquerque, New Mexico); Matthew David Smith (Albuquerque, New Mexico); Charles J. Snider (Albuquerque, New Mexico); John P. Korbin (Albuquerque, New Mexico); Scott Alan Roberts (Albuquerque, New Mexico); Lincoln Collins (Albuquerque, New Mexico) |
| ABSTRACT | Digital image segmentation is provided. The method comprises training a neural network for image segmentation with a labeled training dataset from a first domain, wherein a subset of nodes in the neural net are dropped out during training. The neural network receives image data from a second, different domain. A vector of N values that sum to 1 is calculated for each image element, wherein each value represents an image segmentation class. A label is assigned to each image element according to the class with the highest value in the vector. Multiple inferences are performed with active dropout layers for each image element, and an uncertainty value is generated for each image element. Uncertainty is resolved according to expected characteristics. The label of any image element with an uncertainty above a threshold is replaced with a new label corresponding to a segmentation class based on domain knowledge. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832477 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) Image or Video Recognition or Understanding G06V 10/82 (20220101) G06V 10/764 (20220101) G06V 10/776 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301737 | O'Hara |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Matthew J. O'Hara (Richland, Washington) |
| ABSTRACT | An isotope production system, emanation generator, and process are disclosed for production of high-purity radioisotopes. In one implementation example, high-purity Pb-212 and/or Bi-212 isotopes are produced suitable for therapeutic applications. In one embodiment the process includes transporting gaseous radon-220 from a radium-224 bearing generator which provides gas-phase separation of the Rn-220 from the Ra-224 in the generator. Subsequent decay of the captured Rn-220 accumulates high-purity Pb-212 and/or Bi-212 isotopes suitable for direct therapeutic applications. Other high-purity product isotopes may also be prepared. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/00 (20130101) A61K 51/1289 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) Non-metallic Elements; Compounds Thereof; C01B 23/0073 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 21/00 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/0005 (20130101) G21G 4/08 (20130101) Original (OR) Class G21G 4/10 (20130101) G21G 2001/0084 (20130101) G21G 2001/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220301844 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zane Baird (West Lafayette, Indiana); Pu Wei (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831951 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/622 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0013 (20130101) H01J 49/24 (20130101) Original (OR) Class H01J 49/061 (20130101) H01J 49/142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302400 | WHEELER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance Michael WHEELER (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a device that includes a switchable photovoltaic (PV) device that includes a first active material and a static PV device that includes a second active material, where the switchable PV device and the static PV device are positioned substantially parallel to one another, the switchable PV device has a first state that is substantially transparent to a first wavelength of light in the visible spectrum, the switchable PV device has a second state this is substantially opaque to a second wavelength of light in the visible spectrum, the switchable PV device can be reversibly switched between the first state and the second state, the static PV device is substantially transparent to the visible spectrum of light, and both the switchable PV device and static PV device are capable of generating power. |
| FILED | Friday, July 10, 2020 |
| APPL NO | 17/619375 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0327 (20130101) G02F 2201/08 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0036 (20130101) H01L 51/0074 (20130101) H01L 51/448 (20130101) H01L 51/4213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302447 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei CHEN (Stanford, California); Yi CUI (Stanford, California) |
| ABSTRACT | A rechargeable manganese battery includes: (1) a first electrode including a porous, conductive support; (2) a second electrode including a catalyst support and a catalyst disposed over the catalyst support; and (3) an electrolyte disposed between the first electrode and the second electrode to support reversible precipitation and dissolution of manganese at the first electrode and reversible evolution and oxidation of hydrogen at the second electrode. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833092 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/50 (20130101) Original (OR) Class H01M 4/663 (20130101) H01M 4/926 (20130101) H01M 2300/0005 (20130101) H01M 2300/0017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302449 | CROY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jason CROY (Plainfield, Illinois); Arturo GUTIERREZ (Naperville, Illinois); Michael M. THACKERAY (Naperville, Illinois); Meinan HE (Willowbrook, Illinois) |
| ABSTRACT | Electrode materials for electrochemical cells and batteries and methods of producing such materials are disclosed herein. The electrode materials comprise an active lithium metal oxide material prepared by: (a) contacting the lithium metal oxide material with an aqueous acidic solution containing one or more metal cations; and (b) heating the so-contacted lithium metal oxide from step (a) to dryness at a temperature below 200° C. The metal cations in the aqueous acidic solution comprise one or more metal cations selected from the group consisting of an alkaline earth metal ion, a transition metal ion, and a main group metal ion. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/830116 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/1257 (20130101) C01G 53/50 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/22 (20130101) C01P 2002/32 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 2004/028 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302492 | Visco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | A standalone lithium ion-conductive sulfide solid electrolyte can include a freestanding inorganic vitreous sheet of sulfide-based lithium ion conducting glass capable of high performance in a lithium metal battery by providing a high degree of lithium-ion conductivity while being highly resistant to the initiation and/or propagation of lithium dendrites. Such an electrolyte is also itself manufacturable, and readily adaptable for battery cell and cell component manufacture, in a cost-effective, scalable manner. Methods of making and using the electrolyte, and battery cells and cell components incorporating the electrolyte are also disclosed. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/648120 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/058 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303130 | Qi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing Qi (Knoxville, Tennessee) |
| ABSTRACT | A system and a receiver for generating quantum key(s) using conjugated homodyne detection is provided. The receiver may communicate with a transmitter via an insecure quantum channel and a classical channel to generate the quantum key(s). A decoder, in the receiver, may determine, based at least in part on quadratures X, P measured by conjugated homodyne detectors, a raw-key signal corresponding to a key signal generated by the transmitter, and a distribution of photon numbers corresponding to a quantum signal received via the insecure quantum channel. Information about the key signal is exchanged between the receiver and the transmitter via the classical channel and used to determine a quantum bit error rate of the determined raw-key signal. A gain is also obtained. A secure-key rate is calculated based at least in part on the gain, the quantum bit error rate, and the photon number distribution. |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/699904 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220297395 | HUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianhua HUANG (Blacksburg, Virginia); Daniel Robert METREY (Blacksburg, Virginia) |
| ABSTRACT | Advanced single vacuum bag (ASVB) fabrication methods and assemblies are provided to manufacture and repair polymer composites whereby a rigid check plate is mounted over an uncured laminate by a thermally collapsible check plate stand. The check plate stand thereby maintains a gap between the check plate and the uncured laminate during first stage processing conditions, yet is capable of thermally collapsing during subsequent second stage processing conditions to thereby allow the check plate to fall into compressive contact with the uncured laminate After the check plate collapses onto the uncured laminate, the compressive force of the check plate will be transferred to the laminate to consolidate the laminate as desired and thereby form an at least partially cured polymer composite structure of high quality. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/616094 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/342 (20130101) Original (OR) Class B29C 70/541 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298013 | Michalakos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter M. Michalakos (Arlington Heights, Illinois); Amanda Childers (Arlington Heights, Illinois) |
| ABSTRACT | The disclosure describes a system for generating hydrogen gas from a hydrocarbon through pyrolysis with reduced soot formation and increased carbon loading. The system includes a pyrolysis reactor configured to generate the hydrogen gas from the hydrocarbon through pyrolysis. The pyrolysis reactor includes one or more fibrous substrates configured to provide a deposition surface for carbon generated from the pyrolysis of the hydrocarbon. Each fibrous substrate has an effective void fraction between 40% and 95%, and includes a plurality of fibers configured to maintain chemical and structural stability between about 850° C. and about 1300° C. The one or more fibrous substrates may have a relatively high surface area to fiber volume of the plurality of fibers. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208853 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/008 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/24 (20130101) Original (OR) Class C01B 2203/065 (20130101) C01B 2203/145 (20130101) C01B 2203/0272 (20130101) C01B 2203/0405 (20130101) C01B 2203/1241 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299309 | Komljenovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tin Komljenovic (Goleta, California); Minh Tran (Goleta, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tin Komljenovic (Goleta, California); Minh Tran (Goleta, California) |
| ABSTRACT | A radio frequency generator has first and second lasers configured to emit first and second optical outputs; a reference module configured to receive at least part of the first and second optical outputs from the first and second lasers; a control module connected to the first and second lasers and to the reference module; and an optical-to-electrical (O/E) converter configured to process optical signals, originating from the first and second single-frequency lasers, to provide a radio frequency output. Another radio frequency generator has a control module; and a reference module connected to the control module. The reference module includes a photonic integrated circuit (PIC) having first and second single-frequency lasers configured to emit first and second optical outputs; an unbalanced Mach-Zehnder interferometer (UMZI) with first and second 3×3 optical splitter/combiners; first and second peripheral splitter/combiners; and an output splitter/combiner. |
| FILED | Monday, February 21, 2022 |
| APPL NO | 17/676422 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02001 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/29352 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299346 | Liaghati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir Leon Liaghati (Huntsville, Alabama); Eric Benjamin Delmonico (Madison, Alabama) |
| ABSTRACT | A method for reducing thermal induced error in real-time for a sensor in a region of interest. The method includes receiving at least one data point from a temperature sensor, the temperature sensor configured to determine temperature for the sensor of interest. The method includes receiving at least one data point from the sensor, the sensor having thermal sensitivity and offset shift for a given temperature range. The method includes determining at least three percentage change coefficients for thermal sensitivity. The method includes determining at least three percentage change coefficients for thermal zero offset. The method includes calculating real-time thermal error reduction. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/573772 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 18/008 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/14 (20130101) G01K 7/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299437 | Bathel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett F. Bathel (Yorktown, Virginia); Joshua M. Weisberger (Newport News, Virginia) |
| ABSTRACT | A digital projection and reflected glare reduction system according to various aspects of the present technology may include a digital display device capable of generating a one or two dimensional source grid pattern back-illuminated by a light source to project an image of a source grid onto a retroreflective background. The projected source grid image may then be re-imaged onto the original grid element at a slight offset eliminating the need to generate a separate cutoff grid thereby reducing the amount of time required to setup and adjust the system. The digital display device is also capable of switching between a schlieren visualization capability to some other visualization capability (such as particle tracking velocimetry (PTV), particle imaging velocimetry (NV), temperature sensitive paint measurements (TSP), pressure sensitive paint measurements (PSP), photogrammetry, etc.) allowing for the simultaneous use of two different imaging techniques. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490612 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/455 (20130101) Original (OR) Class G01N 21/958 (20130101) Optical Elements, Systems, or Apparatus G02B 27/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220299484 | Michalakos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter M. Michalakos (Arlington Heights, Illinois); Amanda Childers (Arlington Heights, Illinois); Stephen Yates (South Barrington, Illinois); Sean Skomurski (Highland Park, Illinois) |
| ABSTRACT | The disclosure describes a system for generating hydrogen gas from a hydrocarbon through pyrolysis with reduced soot formation and increased carbon loading. The system includes one or more pyrolysis reactors configured to generate the hydrogen gas from the hydrocarbon through pyrolysis. Each pyrolysis reactor of the one or more pyrolysis reactors includes one or more fibrous substrates and a concentration sensor downstream of at least one fibrous substrate of the one or more fibrous substrates. Each fibrous substrate of the one or more fibrous substrates defines a deposition surface for carbon generated from the pyrolysis of the hydrocarbon and includes a plurality of fibers configured to maintain chemical and structural stability between 850° C. and 1300° C. The concentration sensor is configured to measure a concentration of at least one of a hydrocarbon byproduct or a hydrocarbon soot precursor, such as acetylene. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208933 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/34 (20130101) C01B 3/045 (20130101) C01B 3/50 (20130101) Acyclic or Carbocyclic Compounds C07C 1/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/02 (20130101) Original (OR) Class G01N 2030/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220302999 | VELAZCO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jose E. VELAZCO (Altadena, California) |
| ABSTRACT | Interplanetary networks for space internet and space positioning are presented. The described networks deploy spacecraft swarms along the solar system to form a science and communications platform. The disclosed network nodes are placed around planetary Lagrange points. Creation of optical synthetic apertures using smallsat swarms for inter- and intranet communications is further described. Exemplary subnetworks such as the cislunar network are also presented. |
| FILED | Wednesday, March 16, 2022 |
| APPL NO | 17/696679 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/2676 (20130101) Transmission H04B 7/18521 (20130101) Original (OR) Class H04B 7/18528 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303009 | BOROSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Don M. BOROSON (Needham, Massachusetts); Bryan S. ROBINSON (Arlington, Massachusetts); Jade WANG (Arlington, Massachusetts); Kathleen M. RIESING (Cambridge, Massachusetts); Jamie W. BURNSIDE (Lexington, Massachusetts); Curt Schieler (Acton, Massachusetts); Bryan C. Bilyeu (Wilmington, Massachusetts); Jessica CHANG (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don M. BOROSON (Needham, Massachusetts); Bryan S. ROBINSON (Arlington, Massachusetts); Jade WANG (Arlington, Massachusetts); Kathleen M. RIESING (Cambridge, Massachusetts); Jamie W. BURNSIDE (Lexington, Massachusetts); Curt Schieler (Acton, Massachusetts); Bryan C. Bilyeu (Wilmington, Massachusetts); Jessica CHANG (Cambridge, Massachusetts) |
| ABSTRACT | Communication systems and methods for high-data-rate, high-efficiency, free-space communications are described. High-speed optical modems and automatic repeat request can be employed to transmit large data files without data errors between remote devices, such as an earth-orbiting satellite and ground station. Data rates over 100 Gb/s can be achieved. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578702 |
| CURRENT CPC | Transmission H04B 10/1127 (20130101) Original (OR) Class H04B 10/1129 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220296411 | Maier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin Maier (Darien, Connecticut); Meegan Daigler (Portland, Maine); Ariana Sopher (Portland, Maine); Katie Lim (Brooklyn, New York) |
| ABSTRACT | An applicator for inserting a pessary, the applicator including a barrel and a plunger. The barrel having an upper chalice shaped opening having a first diameter at the top most edge and a second diameter at an intermediate location lower than the top most edge. The first diameter is larger than the second diameter. The plunger is configured to at least partially receive a pessary and is telescopically received in the barrel. The plunger is configured and arranged to eject the pessary from the barrel upon telescopic movement of the plunger within the barrel towards the top most edge. |
| FILED | Wednesday, March 09, 2022 |
| APPL NO | 17/690735 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/005 (20130101) A61F 2/0022 (20130101) A61F 6/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297175 | TAKATA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Keystone Tower Systems, Inc. (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosalind K. TAKATA (Denver, Colorado); Eric D. SMITH (Denver, Colorado); Loren Daniel BRIDGERS (Golden, Colorado); Daniel AINGE (Boulder, Colorado); Alexander H. SLOCUM (Bow, New Hampshire) |
| ABSTRACT | A control system for forming a tapered structure includes a sensor providing feedback for a machine for forming a tapered structure including at least three rolls having at least one bend roll and at least two guide rolls. The guide rolls may include rollette banks having a plurality of rollettes. The machine may also include an adjustment mechanism to position at least one of the rolls, where a diameter of the tapered structure being formed is controlled by relative positions of the rolls. The machine may also include a joining element to join edges of a stock of material together as it is rolled through the rolls to form the tapered structure. The control system may also include a controller to receive feedback from the sensor and to send a control signal based on the feedback to the adjustment mechanism for positioning at least one of the rolls. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825210 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 37/122 (20130101) B21C 37/124 (20130101) B21C 37/126 (20130101) B21C 37/128 (20130101) B21C 37/185 (20130101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 9/0325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220297395 | HUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianhua HUANG (Blacksburg, Virginia); Daniel Robert METREY (Blacksburg, Virginia) |
| ABSTRACT | Advanced single vacuum bag (ASVB) fabrication methods and assemblies are provided to manufacture and repair polymer composites whereby a rigid check plate is mounted over an uncured laminate by a thermally collapsible check plate stand. The check plate stand thereby maintains a gap between the check plate and the uncured laminate during first stage processing conditions, yet is capable of thermally collapsing during subsequent second stage processing conditions to thereby allow the check plate to fall into compressive contact with the uncured laminate After the check plate collapses onto the uncured laminate, the compressive force of the check plate will be transferred to the laminate to consolidate the laminate as desired and thereby form an at least partially cured polymer composite structure of high quality. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/616094 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/342 (20130101) Original (OR) Class B29C 70/541 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220298162 | CANDIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dynavax Technologies Corporation (Berkeley, California) |
| ASSIGNEE(S) | Dynavax Technologies Corporation (Berkeley, California) |
| INVENTOR(S) | Albert Frederick CANDIA (San Mateo, California); Richard Thomas BERESIS (San Francisco, California); Robert L. COFFMAN (Portola Valley, California) |
| ABSTRACT | The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response. |
| FILED | Friday, May 20, 2022 |
| APPL NO | 17/664305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 231/56 (20130101) C07D 235/18 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220298075 | Srubar, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Shane Frazier (Broomfield, Colorado); Elizabeth A. Delesky (Boulder, Colorado); Jaqueline D. Wallat-Pullara (Centennial, Colorado) |
| ABSTRACT | Cement paste compositions, concrete compositions, and methods of forming the cement paste compositions and concrete compositions are disclosed. Exemplary cement paste compositions and concrete compositions include a water-soluble additive that is dissolved and is configured to perform one or more of ice recrystallization inhibition and dynamic ice shaping when the cement composition is exposed to temperatures less than or equal to a freezing temperature of water. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619992 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/2629 (20130101) Original (OR) Class C04B 28/02 (20130101) C04B 40/0046 (20130101) C04B 2103/601 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220300802 | Torres et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| INVENTOR(S) | Francisco E. Torres (San Jose, California); Hoda M. A. Eldardiry (Blacksburg, Virginia) |
| ABSTRACT | Embodiments provide a system and method for performing collaborative learning of machine representations of a concept. During operation, the system can receive a user-specified object associated with a user's concept of interest. The system can compute a similarity score between a target feature vector associated with the user-specified object and a respective feature vector for a set of candidate objects. The system can determine, based on the similarity score, a first subset of candidate objects that satisfy a similarity threshold. The system can receive, via a GUI, a first user-feedback associated with a visual representation of the first subset of candidate objects. The first user-feedback can represent an elaboration of a current user's concept of interest. The system can then modify, based on the first user-feedback, the target feature vector and the similarity function, thereby providing an improved model for machine representations of a current user's concept of interest. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207385 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220298319 | Catchmark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. Catchmark (State College, Pennsylvania); Ke Liu (University Park, Pennsylvania); Kai Chi (Cedar Grove, New Jersey); Jingxuan Yang (University Park, Pennsylvania) |
| ABSTRACT | An insoluble foam composite material is formed by a mixture combining an anionic polysaccharide, a cationic polysaccharide, a solvent, and a plasticizer. In particular, the composite material can be prepared by heating, freezing and lyophilizing the mixture to produce, for example, insoluble porous foam-like composites. |
| FILED | Wednesday, July 29, 2020 |
| APPL NO | 17/631255 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/0061 (20130101) Original (OR) Class C08J 9/228 (20130101) C08J 2303/02 (20130101) C08J 2405/08 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 103/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220301088 | Vemury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland) |
| ABSTRACT | A system and method for processing information from a mobile device. Some configurations may comprise electronically associating biographic or biometric information with an individual having an identity and requiring the individual to be present in a predetermined location during screening. The system and method may include providing a local environment including a front end system and an untrusted mobile device and communicatively coupling a central resource to the front end system. In some configurations the front end system establishes a location of the individual by obtaining information via the mobile device and identifies the mobile device through geo-location to be within the predetermined location. The system and method may provide for collecting biographic or biometric information with the untrusted mobile device; and the front end system may implement a constraint to restrict data input, transmission, receipt, time stamping, etc. from the untrusted mobile device. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831120 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1095 (20130101) G06K 19/06037 (20130101) G06K 19/06112 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/30 (20130101) G06Q 50/265 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220297190 | Hildreth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Owen Hildreth (Lakewood, Colorado); Meredith Heilig (Golden, Colorado); Sanaz Yazdanparast (Golden, Colorado); Subbarao Raikar (Golden, Colorado) |
| ABSTRACT | A method is provided to remove a selective amount of material from a metal component fabricated by additive manufacturing in a self-terminating manner. The method can be used to remove support structures and trapped powder from a metal component as well as to smooth surfaces of a 3D printed metal component. In some embodiments, selected surfaces of the metal component are treated to make the selected surfaces at least one of mechanically and chemically unstable. The unstable portion of the metal support can then be removed chemically, electrochemically, or through vapor-phase etching. The method can be used for processing any fluid or vapor-accessible regions and surfaces of a 3D printed metal component. |
| FILED | Thursday, March 17, 2022 |
| APPL NO | 17/697814 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/40 (20210101) B22F 10/62 (20210101) Original (OR) Class B22F 10/68 (20210101) B22F 2301/10 (20130101) B22F 2301/15 (20130101) B22F 2301/052 (20130101) B22F 2301/205 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/12 (20130101) C23F 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
European Union (EU)
| US 20220301735 | MALMBECK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE EUROPEAN UNION, REPRESENTED BY THE EUROPEAN COMMISSION (Brussels, Belgium) |
| ASSIGNEE(S) | THE EUROPEAN UNION, REPRESENTED BY THE EUROPEAN COMMISSION (Brussels, Belgium) |
| INVENTOR(S) | Rikard MALMBECK (Karlsruhe, Germany); Roberto CACIUFFO (Torino, Italy); Nidhu Lal BANIK (Stutensee, Germany) |
| ABSTRACT | 225actinium is produced from 226radium by irradiating a liquid 226radium target by means of protons, deuterons or gamma irradiation in an irradiation device (2) and by extracting the produced 225actinium out of the irradiated liquid target solution in a first extraction device (6). The liquid target solution from which the 225actinium has been removed is then irradiated again to produce further 225actinium therein. The liquid target solution is preferably circulated, in a closed loop (4), over the irradiation device and in a further closed loop (7) over the first extraction device (6). An advantage of such a method is that the irradiated target solution does not need to be dried and re-dissolved to be able to separate the produced actinium from the radium and no further drying and re-dissolving step is needed for producing the liquid target again starting from the separated radium. The radium target can thus be recycled in a more efficient and safer way, especially in view of the radon gas which is continuously produced by the decay of 226radium. |
| FILED | Monday, June 22, 2020 |
| APPL NO | 17/612602 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 1/10 (20130101) G21G 1/12 (20130101) G21G 2001/0089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220298075 | Srubar, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Wilfred V. Srubar, III (Boulder, Colorado); Shane Frazier (Broomfield, Colorado); Elizabeth A. Delesky (Boulder, Colorado); Jaqueline D. Wallat-Pullara (Centennial, Colorado) |
| ABSTRACT | Cement paste compositions, concrete compositions, and methods of forming the cement paste compositions and concrete compositions are disclosed. Exemplary cement paste compositions and concrete compositions include a water-soluble additive that is dissolved and is configured to perform one or more of ice recrystallization inhibition and dynamic ice shaping when the cement composition is exposed to temperatures less than or equal to a freezing temperature of water. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 17/619992 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/2629 (20130101) Original (OR) Class C04B 28/02 (20130101) C04B 40/0046 (20130101) C04B 2103/601 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220297966 | Perry-Eaton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne Perry-Eaton (Leesburg, Virginia); George W. Potts, JR. (Upper Marlboro, Maryland); Daniel Radtke (Madison, Wisconsin) |
| ABSTRACT | An automated system for transferring articles from a container. An item transfer system includes retainers configured to secure a first tray and a second tray, a movable paddle assembly, a frame, and a plurality of actuators. The system is configured to transfer articles from the first tray to the second tray by an automated process including securing the articles within the first tray with the paddle assembly, rotating the frame by approximately 90° to 100°, moving the paddle assembly in a series of linear translations to remove the items from the first tray and place the items into the second tray, rotating the frame back to its initial orientation, and releasing the items into the second tray. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/805655 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/087 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/137 (20130101) Handling Thin or Filamentary Material, e.g Sheets, Webs, Cables B65H 1/027 (20130101) B65H 5/006 (20130101) B65H 15/02 (20130101) Original (OR) Class B65H 29/02 (20130101) B65H 2301/42242 (20130101) B65H 2301/422542 (20130101) B65H 2301/422548 (20130101) B65H 2701/1916 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220298922 | Wolfer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Francis Wolfer (Cincinnati, Ohio); Richard Alan Wesling (Cincinnati, Ohio) |
| ABSTRACT | A labyrinth seal including: an annular seal body having an inner wall and an outer wall spaced apart from one another by an annulus; a nested dampener system disposed along the outer wall, the nested dampener system including: a first dampening element; and a second dampening element, wherein opposite axial ends of the nested dampener system are defined by the first dampening element, and wherein the second dampening element is disposed outside of at least a portion of the first dampening element in a radial direction. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205059 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/02 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/55 (20130101) Pistons; Cylinders; Sealings F16J 15/447 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303115 | Khoury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joud Khoury (Boston, Massachusetts); Samuel Cunningham Nelson (Sudbury, Massachusetts); William Timothy Strayer (West Newton, Massachusetts) |
| ABSTRACT | Techniques for subscriber revocation in a publish-subscribe network using attribute-based encryption (ABE) are disclosed, including: generating a tree data structure including leaf nodes representing subscribers, subtrees of the tree data structure representing subsets of subscribers having different likelihoods of ABE key revocation; generating ABE keys associated with edges in the tree data structure; assigning ABE keys to the leaf nodes, each leaf node being assigned a subset of the ABE keys associated with edges that form a path from a root node to the leaf node; based at least on a revocation record that indicates one or more revoked subscribers, determining a minimal subset of ABE keys that covers all non-revoked subscribers; and encrypting a payload using an encryption policy requiring at least one ABE key in the minimal subset of the ABE keys, to obtain a ciphertext that is not accessible to the one or more revoked subscribers. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207031 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2246 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/0618 (20130101) Original (OR) Class H04L 9/0861 (20130101) H04L 9/0891 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220303127 | Khoury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joud Khoury (Boston, Massachusetts); Samuel Cunningham Nelson (Sudbury, Massachusetts); William Timothy Strayer (West Newton, Massachusetts) |
| ABSTRACT | Techniques for stream-based key management are disclosed. A system obtains a first payload to be published to a first set of one or more subscribers, encrypts the first payload using a symmetric key, to obtain a first payload ciphertext, encrypts the symmetric key using an attribute-based encryption (ABE) policy associated with the first payload, to obtain a key ciphertext, and publishes the first payload ciphertext and the key ciphertext. The system obtains a second payload to be published to a second set of one or more subscribers. Responsive at least to determining that each subscriber in the second set of one more subscribers is in the first set of one or more subscribers and the ABE policy is associated with the second payload, the system encrypts the second payload using the symmetric key, to obtain a second payload ciphertext, and publishes the second payload ciphertext without republishing the key ciphertext. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207042 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/0618 (20130101) H04L 9/0819 (20130101) H04L 9/0838 (20130101) Original (OR) Class H04L 67/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 22, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220922.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page