FedInvent™ Patent Applications
Application Details for Thursday, December 08, 2022
This page was updated on Saturday, December 10, 2022 at 10:01 PM GMT
Department of Health and Human Services (HHS)
| US 20220386573 | Chupp et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Chupp (San Antonio, Texas); Hong Zan (San Antonio, Texas); Paolo Casali (San Antonio, Texas) |
| ABSTRACT | Described herein are transgenic mice for testing immunogenicity and protective efficacy of a wide variety of therapeutic agents and vaccines, determining allograft rejection, and developing monoclonal antibodies and generating hybridomas. Methods of generating a transgenic mouse is also described. Described herein are mouse models capable of expressing B cell, a T cell, a monocyte, a macrophage, a dendritic cell, a NK cell, a iNKT cell, an innate lymphoid cell, a microglia cell, a red blood cell, which can develop into a functional human immune system. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/776856 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) Original (OR) Class A01K 2207/12 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386862 | Larin et al. |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Kirill V. Larin (Friendswood, Texas); Achuth Nair (Houston, Texas); Manmohan Singh (Houston, Texas); Salavat Aglyamov (Friendswood, Texas) |
| ABSTRACT | A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882682 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/16 (20130101) A61B 3/0025 (20130101) Original (OR) Class A61B 3/102 (20130101) A61B 3/165 (20130101) A61B 5/0051 (20130101) A61B 5/0053 (20130101) A61B 5/0066 (20130101) A61B 5/0093 (20130101) A61B 5/0097 (20130101) A61B 8/10 (20130101) A61B 8/485 (20130101) A61B 2576/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386872 | Chen et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hong Chen (St. Louis, Missouri); Arash Nazeri (St. Louis, Missouri); Christopher Pacia (St. Louis, Missouri); Eric Leuthardt (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819815 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/6803 (20130101) A61B 8/0808 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386905 | Jacobs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pacific Diabetes Technologies Inc (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter G. Jacobs (Portland, Oregon); Clara Mosquera-Lopez (Portland, Oregon); Nichole Tyler (Portland, Oregon); Robert S. Cargill (Portland, Oregon); Thomas L. Seidl (Wilsonville, Oregon); William Kenneth Ward (Portland, Oregon) |
| ABSTRACT | The present disclosure provides methods of measuring of an analyte in a subject to remove a measurement artifact by using a forecasting model to determine the true analyst concentration in a subject. Also herein, the present disclosure provides parameters and models to estimate the true analyte concentration in a subject. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/684015 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387305 | Szewczyk |
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| FUNDED BY |
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| APPLICANT(S) | Biokier, Inc. (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | Biokier, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jerzy Ryszard Szewczyk (Chapel Hill, North Carolina) |
| ABSTRACT | A method of treating diabetes Type 2 by delivery of butyric acid, bile acid, long-chain fatty acid, or glutamine to the colon by bypassing the upper digestive tract, with the composition combined either by the same or different route of administration with a DPP-IV inhibitor such as vildagliptin. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890655 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0004 (20130101) A61K 9/0031 (20130101) Original (OR) Class A61K 9/2004 (20130101) A61K 9/2013 (20130101) A61K 9/2077 (20130101) A61K 9/2846 (20130101) A61K 9/2866 (20130101) A61K 31/19 (20130101) A61K 31/40 (20130101) A61K 31/195 (20130101) A61K 31/198 (20130101) A61K 31/575 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387311 | KANASTY et al. |
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| APPLICANT(S) | Lyndra Therapeutics, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rosemary KANASTY (Somerville, Massachusetts); Tyler GRANT (Arlington, Massachusetts); David ALTREUTER (Wayland, Massachusetts); Alisha WEIGHT (Cambridge, Massachusetts); Saumya MOORTHY (Medford, Massachusetts); Tammy TAI (Cambridge, Massachusetts); Juan Jaramillo MONTEZCO (Cambridge, Massachusetts); Marlene SCHWARZ (Auburndale, Massachusetts); Jung Hoon YANG (Brookline, Massachusetts); Jeanne TRAN (Brighton, Massachusetts); Michelle DUAN (Wellesley, Massachusetts); Jie JING (Watertown, Massachusetts); David C. DUFOUR (Watertown, Massachusetts); Erik Robert Waldemar RYDE (Watertown, Massachusetts); Nupura BHISE (Watertown, Massachusetts); Nicholas DE LA TORRE (Boston, Massachusetts); Sonia HOLAR (Boston, Massachusetts); Estelle BEGUIN (Watertown, Massachusetts); Craig SIMSES (Quincy, Massachusetts); Erick PEEKE (Cambridge, Massachusetts); Erica LAI (Somerville, Massachusetts) |
| ABSTRACT | Gastric residence systems for administration of agents, such as drugs, are disclosed. Features which enhance gastric retention during the desired residence time and which allow for more precise control over residence time are disclosed, including circumferential filaments connecting the arms of a stellate gastric residence system; flexible arms for a gastric residence system; improved time-dependent and enteric disintegrating matrices (linkers); and release rate-modulating polymer coatings which are resistant to change in release rate properties during heat-assisted assembly or thermal cycling. Combinations of these features are also disclosed. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774132 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0065 (20130101) Original (OR) Class A61K 31/13 (20130101) A61K 31/70 (20130101) A61K 31/445 (20130101) A61K 31/519 (20130101) A61K 47/34 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387316 | LUKACS et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (ANN ARBOR, Michigan) |
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| INVENTOR(S) | NICHOLAS LUKACS (ANN ARBOR, Michigan); JAMES R. BAKER, Jr. (ANN ARBOR, Michigan); JESSICA O'KONEK (ANN ARBOR, Michigan) |
| ABSTRACT | The disclosure is directed to compositions and methods for treating aeroallergen induced inflammation (e.g., airway inflammation). The compositions comprise a nanoemulsion and one or more aeroallergens. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/775743 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/1075 (20130101) Original (OR) Class A61K 39/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 37/08 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387337 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/839699 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387356 | Lawrence et al. |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); EASTERN MICHIGAN UNIVERSITY (Ypsilanti, Michigan) |
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| INVENTOR(S) | Daniel A. Lawrence (Ann Arbor, Michigan); Cory Emal (Ann Arbor, Michigan); Ashley Reinke (Appleton, Wisconsin); Shih-Hon Li (Canton, Michigan) |
| ABSTRACT | Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883245 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387358 | Loughran, JR. et al. |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas P. Loughran, JR. (Charlottesville, Virginia); David J. Feith (Palmyra, Virginia); Su-Fern Tan (Charlottesville, Virginia); Jennifer M. Pearson (Charlotte, North Carolina); Mark Kester (Afton, Virginia); Tye Deering (Charlottesville, Virginia); Todd Fox (Charlottesville, Virginia); Helena Woodvine Snyder (Crozet, Virginia); Anuradha Illendula (Crozet, Virginia) |
| ABSTRACT | Provided are methods for treating a disease, disorder, or condition associated with an acid ceramidase (AC) biological activity. The methods include administering to a subject in need thereof a composition including an AC inhibitor and at least one additional active agent, such as a C6-ceramide nanoliposome (CNL); an inhibitor of a Bcl-2 family protein; a hypomethylating agent; an intensive chemotherapeutic agent such as cytarabine (AraC) and/or daunorubicin; a Hedgehog pathway inhibitor; a targeted agent, such as a FLT2 inhibitor or a EDH1/2 inhibitor; and/or an antibody drug conjugate that targets, for example, CD-33. The composition can include N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-chloroacetamide (SACLAC) or a pharmaceutically acceptable salt thereof and at least one additional active agent. The disease, disorder, or condition associated with the AC biological activity can be a cancer, such as acute myeloid leukemia (AML). |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/775213 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1271 (20130101) A61K 31/164 (20130101) Original (OR) Class A61K 31/635 (20130101) A61K 31/706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387359 | Xiao et al. |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
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| INVENTOR(S) | Xiangshu Xiao (Portland, Oregon); Funchun Xie (Portland, Oregon); Bingbing Li (Portland, Oregon) |
| ABSTRACT | Disclosed herein are uses for a compound of Formula (I), below, or a pharmaceutically acceptable salt thereof: wherein n is an integer selected from the group of 0, 1, 2, 3, and 4, or a pharmaceutically acceptable salt thereof, for enhancing the effect of an anti-cancer agent, such as an inhibitor of CREB-mediated gene transcription. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387367 | Kumar et al. |
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| APPLICANT(S) | Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
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| INVENTOR(S) | Sanjay S. Kumar (Tallahassee, Florida); Stephen Beesley (Tallahassee, Florida) |
| ABSTRACT | D-serine is effective for inhibiting neuron loss due to an immune response by glial cells to a brain injury. An example of a method includes artificially administering a composition including D-serine to brain cells after an injury thereto, the composition including an amount of D-serine effective to inhibit death of neurons. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0073 (20130101) A61K 31/198 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387379 | LIANG |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Jing LIANG (Los Angeles, California) |
| ABSTRACT | Herbal compositions comprising dihydromyricetin (DHM) and methods of use. The herbal compositions include DHM in combination with other ingredients to form compositions that can significantly improve the quality and duration of sleep, reduce the time for onset of improved sleep quality and duration, and treat or alleviate the symptoms of sleep-related disorders and neurological conditions. The composition is a therapeutic alternative to drugs to alleviate sleep disorders and related symptoms and ailments. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728041 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/585 (20130101) A61K 31/4045 (20130101) A61K 36/35 (20130101) A61K 36/81 (20130101) A61K 36/575 (20130101) A61K 36/725 (20130101) A61K 36/752 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387380 | LI et al. |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Rong LI (Washington, District of Columbia); Bin YUAN (Hefei City, China PRC); Tyler CURIEL (San Antonio, Texas) |
| ABSTRACT | The present invention provides methods and compositions for treating or preventing melanoma with S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387387 | Burgess et al. |
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| APPLICANT(S) | Robert W. Burgess (Bar Harbor, Maine); Emily Spaulding (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Robert W. Burgess (Bar Harbor, Maine); Emily Spaulding (Bar Harbor, Maine) |
| ABSTRACT | Provided herein, in some embodiments, are methods and compositions for the treatment of Charcot-Marie-Tooth disease. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288178 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/4162 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 25/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387412 | Rangnekar et al. |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek M. Rangnekar (Nicholasville, Kentucky); David S. Watt (Lexington, Kentucky); Ravshan Burikhanov (Lexington, Kentucky); Vitaliy Sviripa (Lexington, Kentucky) |
| ABSTRACT | A composition and method for treating tumor cells are provided. The composition includes at least one ebastine derivative having a structure according to Formula I. The method include administering, to a patient in need thereof, an effective amount of the composition including at least one ebastine derivative having the structure according to Formula I. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/770267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/45 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387432 | Alam et al. |
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| FUNDED BY |
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| APPLICANT(S) | EIP Pharma, Inc. (Boston, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | EIP Pharma, Inc. (Boston, Massachusetts); Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | John Jahangir Alam (Boston, Massachusetts); David A. Harris (Boston, Massachusetts); Cheng Fang (Boston, Massachusetts) |
| ABSTRACT | The present invention provides methods and compositions for treatment of prion disease. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220387442 — PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF
| US 20220387442 | MARCANTONIO et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARMGO Pharma, Inc. (Ardsley, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene E. MARCANTONIO (Tenafly, New Jersey); Mette Uhre ANBY (Frederiksberg, Denmark); Jérôme BINET (Saint Denis en Val, France) |
| ABSTRACT | The present disclosure provides a modified-release pharmaceutical composition comprising 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)yl)methyl]benzoic acid hemifumarate, and a pharmaceutically-acceptable excipient. The present disclosure methods of treating conditions associated with RyRs, including, for example, cardiac disorder or disease, a musculoskeletal disorder or disease, cancer associated muscle weakness, malignant hyperthermia, and diabetes. |
| FILED | Thursday, May 19, 2022 |
| APPL NO | 17/748886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/2866 (20130101) A61K 9/2886 (20130101) A61K 31/554 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387457 | Htoo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Qlaris Bio, Inc. (Wellesley, Massachusetts); Mayo Foundation for Medicalo Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Qlaris Bio, Inc. (Wellesley, Minnesota); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Thurein M. Htoo (Waban, Massachusetts); Barbara M. Wirostko (Park City, Utah); Michael P. Fautsch (Rochester, Minnesota) |
| ABSTRACT | New medical uses for the compounds of Formula I, II, or III or a pharmaceutically acceptable salt thereof. |
| FILED | Friday, August 05, 2022 |
| APPL NO | 17/882270 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387459 | VOLPE et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew R. VOLPE (Cambridge, Massachusetts); Emily BALSKUS (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to methods and compositions for inhibition of ClbP and the treatment and/or prevention of cancer, e.g., colorectal cancer, a urinary tract cancer, a squamous cell carcinoma, an oral squamous cell carcinoma, or a head-and-neck cancer. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/771949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387460 | Azab et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Abdel Kareem Azab (St. Louis, Missouri); Cinzia Federico (St. Louis, Missouri) |
| ABSTRACT | Compositions and methods of treatment for multiple myeloma (MM) are disclosed that include a liposome with a lipid bilayer shell enclosing a fluid-filled center, a targeting moiety coupled to the outer surface of the shell, a treatment compound disposed within the lipid bilayer shell or within the fluid-filled center, and an efficacy-enhancing compound disposed within the lipid bilayer shell or within the fluid-filled center. In some embodiments, the targeting moiety is PSGL-1, the proteasome-inhibiting compound is bortezomib, and the BMME-disrupting agent is a CXCR4 inhibitor or ROCK inhibitor. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/776186 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/4891 (20130101) A61K 31/69 (20130101) Original (OR) Class A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387493 | KONDURI et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| INVENTOR(S) | Vanaja KONDURI (Houston, Texas); William K. DECKER (Houston, Texas); Matthew M. HALPERT (Houston, Texas); Meenakshi G. HEGDE (Houston, Texas); Nabil M. AHMED (Houston, Texas); Sujith K. JOSEPH (Houston, Texas) |
| ABSTRACT | Provided herein are methods of expanding CD161+ T cells. Also provided are methods and compositions for generating modified CD161+ T cells comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T cells are produced, expanded, and/or used in disease (e.g, cancer) treatments. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/774848 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 2039/5156 (20130101) Peptides C07K 14/7051 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387512 | Ji et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ru-Rong Ji (Durham, North Carolina); Gang Chen (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are bone marrow stromal cells. The bone marrow stromal cells may express and/or secrete TGF-β1. The bone marrow stromal cells may express CXCR4. Also disclosed herein is a method of treating pain in a subject in need thereof. The method of treating may include administration of the bone marrow stromal cells to the subject. The pain may be neuropathic pain. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 38/1841 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387513 | Meyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason S. Meyer (Whitestown, Indiana); Clarisse Fligor (Indianapolis, Indiana) |
| ABSTRACT | Various aspects and embodiments disclosed herein relate generally to the stem cell biology and cell replacement therapy. Embodiments include compositions and methods for modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of a condition/disease associated with retinal degenerative diseases or a related clinical condition thereof. Other embodiments include methods and compositions for developing pluripotent stem cell-derived 3D tissues. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770183 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387548 | PUTTUR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SANTHOSHKUMAR PUTTUR (COLUMBIA, Missouri); KRISHNA SHARMA (COLUMBIA, Missouri); SUNDARARAJAN MAHALINGAM (COLUMBIA, Missouri) |
| ABSTRACT | The present disclosure provides amphiphilic peptide chaperones. Also provided are their incorporation into pharmaceutical compositions and methods of use for preventing or reducing a source of stress in cells and for the treatment of disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), cataract, age-related macular degeneration (AMD), glaucoma, and retinitis pigmentosa. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830565 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class A61K 47/542 (20170801) A61K 47/6929 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387565 | Troy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carol M. Troy (Hastings-on-Hudson, New York); Ying Y. Jean (New York, New York) |
| ABSTRACT | The present disclosure relates to a method for treating diabetic macular edema (DME) and/or retinal vein occlusion (RVO) comprising administering to the retina of a patient in need thereof an effective amount of a caspase-9 signaling pathway inhibitor. The caspase-9 signaling pathway inhibitor may include a peptide caspase-9 inhibitor and/or may be conjugated to a cell-penetrating peptide. The present disclosure further includes pharmaceutical compositions including a caspase-9 signaling pathway inhibitor. The disclosure further relates to the use of such compositions in a method for treating DME and/or RVO. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538924 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 38/55 (20130101) Original (OR) Class A61K 47/64 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387567 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Birmingham (Birmingham, United Kingdom); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); The University of Birmingham (Birmingham, United Kingdom); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Donald F. Hunt (Charlottesville, None); Jeffrey Shabanowitz (Charlottesville, None); Keira Mahoney (New Haven, Connecticut); Jennifer G. Abelin (Boston, Massachusetts); Mohammad Ovais Azizzanjani (Palo Alto, California); Paisley Trantham Myers (Irmo, None); Stacy Alyse Malaker (New Haven, Connecticut); Andrew Norris (Oilville, None); Jennifer Hitchcock (Midlothian, Virginia); Xi Peng (Charlottesville, None); Negin Ghafourian (Charlottesville, None); Mark Cobbold (Winchester, None); Sarah Penny (Birmingham, United Kingdom); Nico Buettner (Birmingham, United Kingdom); James M. Heather (Boston, Massachusetts) |
| ABSTRACT | Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein. Also provided are in vitro populations of dendritic cells that include the compositions, in vitro populations of T cells capable of being activated uponbeing brought into contact with the populations of dendritic cells, antibodies and antibody-like molecules that specifically bind to complexes of an MHC class I molecule and the peptides, methods for using the disclosed compositions for treating and/or preventing cancer and/or microbial infections, methods for making cancer vaccines and anti-microbial vaccine, methods for screening peptides for inclusion in immunotherapy compositions, methods for determining a prognosis of a patient with a cancer and/or a microbial infection, kits that include the disclosed peptides, and methods for treating and/or preventing diseases, disorders, and/or conditions associated with hyperphosphorylation of MHC I peptides and/or MHC II peptides, inadequate PP2A activity, and/or undesirable CIP2A activity. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441662 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 2039/57 (20130101) A61K 2039/585 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387578 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Xiaozhen HU (San Diego, California); William SCHIEF (Encinitas, California) |
| ABSTRACT | The present disclosure is directed to peptide antigens derived from a previously undefined epitope on influenza A virus hemagglutinin and methods for use thereof. |
| FILED | Saturday, May 16, 2020 |
| APPL NO | 17/611564 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/148 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 47/44 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387585 | MIRKIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (EVANSTON, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. MIRKIN (Wilmette, Illinois); Andrew LEE (Chicago, Illinois); Bin ZHANG (Chicago, Illinois); Donye DOMINGUEZ (Evanston, Illinois) |
| ABSTRACT | The disclosure is related to compositions comprising a cell and a spherical nucleic acid (SNA) comprising a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen; and to methods for production of such compositions and their applications, including but not limited to adoptive cell therapy. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/814211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 39/001192 (20180801) A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/141 (20130101) C12N 2310/532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387607 | FLYNN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GanNA Bio, Inc. (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan A. FLYNN (Brookline, Massachusetts); Brian GOODMAN (Boston, Massachusetts); Ciaran LAWLOR (Milton, Massachusetts); Namita BISARIA (Somerville, Massachusetts); Richard D. CUMMINGS (Brookline, Massachusetts); Mohui WEI (Boston, Massachusetts); Carolyn R. BERTOZZI (Menlo Park, California) |
| ABSTRACT | The present disclosure relates to glyconucleic acids, such as glycoRNA and glycoDNA described herein. Provided are glycosylated ribonucleic acid (glycoRNA)-related methods and compositions. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825737 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/61 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387610 | XU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing XU (Newton, Massachusetts); Jiaqing WANG (Waltham, Massachusetts) |
| ABSTRACT | The present disclosure relates to a conjugated prodrug comprising a peptide conjugated to an antibiotic molecules via a cleavable linker and pharmaceutical compositions thereof. Also disclosed are methods of enhancing the intracellular concentration of an antibiotic agent in a bacterium and methods of treating a patient for a bacterial infection. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387612 | Walz |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OPHIDION INC. (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andreas Walz (Bethlehem, Pennsylvania) |
| ABSTRACT | Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier. |
| FILED | Tuesday, July 05, 2022 |
| APPL NO | 17/810776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 45/06 (20130101) A61K 47/42 (20130101) A61K 47/56 (20170801) A61K 47/64 (20170801) Original (OR) Class A61K 48/00 (20130101) Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387619 | de los Pinos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Elisabet de los Pinos (Brookline, Massachusetts); John Todd Schiller (Kensington, Maryland); Rhonda C. Kines (Washington, District of Columbia); John MacDougall (Hingham, Massachusetts) |
| ASSIGNEE(S) | Aura Biosciences, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Serv. (Bethesda, Maryland) |
| INVENTOR(S) | Elisabet de los Pinos (Brookline, Massachusetts); John Todd Schiller (Kensington, Maryland); Rhonda C. Kines (Washington, District of Columbia); John MacDougall (Hingham, Massachusetts) |
| ABSTRACT | The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395369 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 41/0057 (20130101) A61K 41/0071 (20130101) A61K 47/64 (20170801) A61K 47/6901 (20170801) Original (OR) Class A61K 2039/545 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Peptides C07K 1/13 (20130101) C07K 14/025 (20130101) C07K 16/32 (20130101) C07K 16/084 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387626 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi CHEN (Milford, Connecticut); Guangchuan WANG (West Haven, Connecticut); Ryan D. CHOW (San Jose, California); Feifei ZHANG (New Haven, Connecticut) |
| ABSTRACT | The present invention includes compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 38/195 (20130101) A61K 38/1774 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/1082 (20130101) C12N 2310/20 (20170501) C12N 2710/10343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387631 | Frangioni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center (Boston, Massachusetts); Georgia State University Research Foundation Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John V. Frangioni (Wayland, Massachusetts); Hak Soo Choi (Needham, Massachusetts); Maged M. Henary (Lawrenceville, Georgia) |
| ABSTRACT | The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/003 (20130101) A61K 49/0017 (20130101) A61K 49/0021 (20130101) Original (OR) Class A61K 49/0028 (20130101) A61K 49/0032 (20130101) A61K 49/0041 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 17/00 (20130101) C09B 19/00 (20130101) C09B 23/04 (20130101) C09B 23/0016 (20130101) C09B 23/0025 (20130101) C09B 23/0033 (20130101) C09B 23/0041 (20130101) C09B 23/0066 (20130101) C09B 23/083 (20130101) C09B 23/086 (20130101) C09B 57/10 (20130101) C09B 69/008 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387633 | LAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kit S. LAM (Davis, California); Lu ZHANG (Sacramento, California) |
| ABSTRACT | The present invention provides a compound of formula (I): A-B-C (I), wherein A is a hydrophobic moiety; B is a peptide, wherein the peptide forms a beta-sheet; and C is a hydrophilic targeting ligand, wherein the hydrophilic targeting ligand is a LLP2A prodrug, LLP2A, LXY30, LXW64, DUPA, folate, a LHRH peptide, a HER2 ligand, an EGFR ligand, or a toll-like receptor agonist CpG oligonucleotides. The present invention also provides nanocarriers comprising compounds of the present invention, nanofibril formation from the nanocarriers, and methods of using the nanocarriers for treating diseases and imaging. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 17/634410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/546 (20170801) A61K 47/6929 (20170801) A61K 49/0036 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 49/0093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387635 | NAJJAR |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Amer NAJJAR (Houston, Texas) |
| ABSTRACT | The present disclosure provides methods of imaging cancerous cells in a subject, wherein the cancerous cells are localized to the skeletal system or central nervous system of the subject, the method comprising administering to the subject an effective amount of 18F-fluoroacetate, detecting a first signal emitted by 18F-fluoroacetate, and generating an image representative of the location and/or amount of the first signal to image the cancerous cells. In some embodiments, the methods further comprising diagnosing, prognosing, staging, and/or monitoring the progression of a disease or disorder, such as acute lymphoblastic leukemia and/or leptomeningeal disease. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/774136 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387660 | Abuid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas J. Abuid (Gainesville, Florida); Jiapu Liang (Gainesville, Florida); Cherie Stabler (Gainesville, Florida) |
| ABSTRACT | The present disclosure provides for oxygen generating and free radical scavenging biomaterials, an article including the oxygen generating and free radical scavenging biomaterial, wound healing dressings or structures (e.g., bandage) that have the characteristic of generating oxygen and having redox modulating capabilities. In particular, the wound healing dressing can have the characteristics of being anti-inflammatory, antioxidant, and pro-healing for extended periods of time (e.g., at least 10 days, at least 30 days). |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/772709 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/44 (20130101) Original (OR) Class A61L 2300/11 (20130101) A61L 2300/41 (20130101) A61L 2300/102 (20130101) A61L 2300/412 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387668 | Jurkunas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts); The Schepens Eye Research Institute, Inc. (Boston, Massachusetts); Children`s Medical Center Corporation (Boston, Massachusetts); DANA FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ula Jurkunas (Winchester, Massachusetts); Reza Dana (Newton, Massachusetts); Myriam Anne Armant (Boston, Massachusetts); Jerome Ritz (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods for generating cultivated autologous limbal epithelial cell grafts for the treatment of various disorders caused by limbal stem cell deficiency. This invention relates to methods and compositions for treating ophthalmic disorders, diseases and injuries. In particular, the field of the invention is directed to methods, kits and compositions for treating disorders, diseases, defects and injuries of the cornea and ocular surface. The present disclosure relates to preparations of cultured mammalian limbal stem cells, derived from corneal limbus tissue. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/775054 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3604 (20130101) Original (OR) Class A61L 27/3813 (20130101) A61L 27/3834 (20130101) A61L 27/3895 (20130101) A61L 2430/16 (20130101) A61L 2430/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387670 | Badylak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen F. Badylak (West Lafayette, Indiana); Hong Jiang (Export, Pennsylvania); Hideyoshi Sato (Pittsburgh, Pennsylvania); William R. Wagner (Gibsonia, Pennsylvania); Yang Zhu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein is an injectable hydrogel composition that forms a porous gel rapidly after injection. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel. |
| FILED | Tuesday, June 14, 2022 |
| APPL NO | 17/840005 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/26 (20130101) A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/56 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 33/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387801 | Schmidt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Schmidt (Durham, North Carolina); Warren Grill (Durham, North Carolina) |
| ABSTRACT | Embodiments of the present disclosure include a method for acquiring, with a device, a plurality of electrical signals from a brain of a subject, and determining whether a biomarker is present in the plurality of electrical signals. The biomarker comprises at least one phase metric associated with the electrical signal, and further includes adjusting at least one therapy parameter based on biomarker assessment. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/829449 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36135 (20130101) Original (OR) Class A61N 1/36146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388838 | Cao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bionano Genomics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han Cao (San Diego, California); Michael David Austin (San Diego, California); Parikshit A. Deshpande (San Diego, California); Mark Kunkel (San Diego, California); Alexey Y. Sharonov (San Diego, California); Michael Kochersperger (San Diego, California) |
| ABSTRACT | Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided |
| FILED | Monday, March 21, 2022 |
| APPL NO | 17/700299 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/10 (20130101) B01L 2200/0663 (20130101) B01L 2200/0689 (20130101) B01L 2300/168 (20130101) B01L 2300/0816 (20130101) B01L 2300/0851 (20130101) B01L 2300/0858 (20130101) B01L 2300/0864 (20130101) B01L 2300/0887 (20130101) B01L 2400/043 (20130101) B01L 2400/086 (20130101) B01L 2400/0415 (20130101) B01L 2400/0442 (20130101) B01L 2400/0487 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/058 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00119 (20130101) Original (OR) Class B81C 2201/019 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2021/0346 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/4981 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388962 | CARLSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biohaven Therapeutics Ltd. (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marianne CARLSEN (Yardley, Pennsylvania); Garry R. SMITH (Elverson, Pennsylvania); Randall J. BINDER (Conshohocken, Pennsylvania); Camille REMEUR (Toulouse, France); Allen B. REITZ (Lansdale, Pennsylvania); Xiao JIN (King of Prussia, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimer's disease, and Alzheimer's disease related disorder, and disease that involve excess amounts of TDP-43 in the cytosol. |
| FILED | Friday, August 21, 2020 |
| APPL NO | 17/635421 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 215/42 (20130101) Original (OR) Class C07D 215/46 (20130101) C07D 401/04 (20130101) C07D 401/10 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/04 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 413/14 (20130101) C07D 471/04 (20130101) C07D 487/04 (20130101) C07D 487/10 (20130101) C07D 491/056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388968 | Low et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Stewart Low (West Lafayette, Indiana); Daniel A. Sheik (Lafayette, Indiana); Som Dutt (Shamli Uttar, India) |
| ABSTRACT | Inhibitors of erythrocyte band 3 tyrosine phosphorylation, compositions comprising same, and methods of using the inhibitors and compositions to treat sickle cell diseases. |
| FILED | Thursday, June 18, 2020 |
| APPL NO | 17/620043 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Heterocyclic Compounds C07D 239/48 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388993 | Georg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Ingrid Gunda Georg (Minneapolis, Minnesota); Narsihmulu Cheryala (Minneapolis, Minnesota) |
| ABSTRACT | The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents. |
| FILED | Tuesday, May 03, 2022 |
| APPL NO | 17/735918 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) Heterocyclic Compounds C07D 405/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389028 | Matsuyama et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shigemi Matsuyama (Cleveland, Ohio); William Greenlee (Cleveland, Ohio) |
| ABSTRACT | A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/615377 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 13/28 (20130101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 491/048 (20130101) C07D 495/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389030 | Ghosh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Andrew Mesecar (West Lafayette, Indiana); Margherita Brindisi (Corleto Perticara, Italy); Emilio Leal Cardenas (West Lafayette, Indiana) |
| ABSTRACT | Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567737 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/78 (20130101) Heterocyclic Compounds C07D 307/22 (20130101) C07D 309/14 (20130101) C07D 513/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389036 | Duerfeldt et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Duerfeldt (Norman, Oklahoma); Jian-xing Ma (Edmond, Oklahoma); Xiaozheng Dou (Norman, Oklahoma); Dinesh Nath (Meerut, India); Young-Hwa Shin (Oklahoma City, Oklahoma) |
| ABSTRACT | Benzyl derivative compounds having peroxisome proliferator-activated receptor α (PPARα) agonistic activity, kits and compositions containing such compounds, and methods of their use in enhancing PPARα activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema. |
| FILED | Thursday, July 28, 2022 |
| APPL NO | 17/876243 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/301 (20130101) C07F 9/3808 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389062 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Serge Gueroussov (Boston, Massachusetts) |
| ABSTRACT | Provided herein are non-naturally occurring self-assembling polypeptides for transferring nucleic acids and/or proteins to a cell, pharmaceutical compositions comprising such polypeptides, and methods for treatment comprising use of such compositions. The methods for producing polypeptide compositions may include combining in a solution, unassembled recombinant GAG-like proteins, nucleic acids and/or proteins in low salt conditions; and increasing the ionic strength of the solution. |
| FILED | Friday, February 25, 2022 |
| APPL NO | 17/681479 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/506 (20130101) C12N 15/11 (20130101) Enzymes C12Y 304/23 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389067 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Bingwei Lu (Stanford, California); Zhihao Wu (Palo Alto, California); Shuangxi Li (Stanford, California) |
| ABSTRACT | Methods of treating subjects having G4C2 dipeptide repeat expansion in the gene C9ORF72, including subjects having amyotrophic lateral sclerosis or frontotemporal degeneration (ALS/FTD), are provided. Compounds directed at reducing the toxicity of G4C2 dipeptide repeat expansion in the gene C9ORF72 are described. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/755716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389074 | CHAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Yu-Wah CHAN (Pittsburgh, Pennsylvania); Wei SUN (Sewickley, Pennsylvania) |
| ABSTRACT | Disclosed herein are compositions and methods for treating pulmonary hypertension whereby a SCUBE1 polynucleotide or polypeptide is administered. Also disclosed herein are methods for diagnosing and/or prognosing pulmonary arterial hypertension or pulmonary hypertension with high pulmonary vascular resistance that include detecting an amount of a SCUBE1 polynucleotide or polypeptide. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776569 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 9/12 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389088 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weizhou Zhang (Gainesville, Florida); Ryan Harrison Kolb (Gainesville, Florida) |
| ABSTRACT | Described herein are anti-angiopoictin-like 4 (ANGPTL4) antibodies and methods of treating disorders associated with elevated expression of ANGPTL4. In one aspect, described herein is an antibody or antigen binding fragment thereof that binds angiopoietin-like 4 (ANGPTL4) comprising amino acid sequences set forth in (a) SEQ ID NOs: 3-8 (Ab-A CDRs), (b) SEQ ID NOs: 13-18 (Ab-B CDRs), (c) SEQ ID NOs: 23-28 (Ab-C CDRs), (d) SEQ ID NOs: 33-38 (Ab-D CDRs), or (e) SEQ ID NOs: 43-48 (Ab-E CDRs). |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/771339 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/55 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389093 | Hanada et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kenichi Hanada (Bethesda, Maryland); Qiong J. Wang (Highland Park, New Jersey); James C. Yang (Bethesda, Maryland); Zhiya Yu (Potomac, Maryland) |
| ABSTRACT | Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Thursday, August 04, 2022 |
| APPL NO | 17/817599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389094 | Orentas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lentigen Technology, Inc. (Gaithersburg, Maryland); The U.S.A. as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rimas J. Orentas (Seattle, Washington); Dina Schneider (Potomac, Maryland); Boro Dropulic (Ellicott City, Maryland); Dimiter S. Dimitrov (Frederick, Maryland); Zhongyu Zhu (Frederick, Maryland) |
| ABSTRACT | Chimeric antigen receptors containing ROR1 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/820785 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/15 (20130101) C07K 14/7051 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70525 (20130101) C07K 14/70532 (20130101) C07K 14/70535 (20130101) C07K 14/70575 (20130101) C07K 14/70589 (20130101) C07K 16/28 (20130101) Original (OR) Class C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/113 (20130101) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389102 | Chan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (Munich, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. Chan (Cortlandt Manor, New York); Diego Chowell Puente (New York, New York); Chirag Krishna (Redwood City, California); Tobias Leander Lenz (Hamburg, Germany); Federica Pierini (Rome, Italy) |
| ABSTRACT | Molecular determinants of cancer response to immunotherapy are described. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/770259 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Original (OR) Class C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389380 | Fiering |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHARLES STARK DRAPER LABORATORY, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason O. Fiering (Boston, Massachusetts) |
| ABSTRACT | A method for separating cells in a biofluid includes pretreating the biofluid by introducing a predetermined amount of a cocktail of antibodies, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the pretreated biofluid within the microfluidic separation channel. A system for microfluidic cell separation, capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of an additive including the cocktail of antibodies, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic cell separation is also disclosed. A method of facilitating separation of cells is also disclosed. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834652 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/16 (20130101) B01L 2200/0636 (20130101) B01L 2200/0652 (20130101) B01L 2400/0436 (20130101) B01L 2400/0439 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0081 (20130101) C12N 5/0634 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389390 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. Schaffer (Danville, California); Melissa A. Kotterman (Berkeley, California); Bum-Yeol Hwang (Moraga, California); James T. Koerber (San Francisco, California) |
| ABSTRACT | The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/725289 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389393 | Halmai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julian Halmai (Davis, California); Kyle Fink (Davis, California); Peter Deng (Davis, California) |
| ABSTRACT | A gene editing system is provided that comprises a first nucleotide molecule encoding a dCas9-Ten-Eleven Translocation methylcytosine dioxygenase 1 catalytic domain (TET1CD) fusion protein; and a second nucleotide molecule encoding at least one small guide RNA (sgRNA), comprising: a scaffold region and a spacer region, wherein the spacer region hybridizes to a nucleotide sequence complementary to a target sequence adjacent to a 5′-end of a protospacer adjacent motif (PAM), and wherein the target sequence and the PAM are located within 1 kilobase (kb) of the transcriptional start site (TSS) of the CDKL5 gene. Methods of making and using the system are further described herein. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389407 | Opijnen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | The Trustees of Boston College (Chestnut Hill, Massachusetts) |
| INVENTOR(S) | Tim van Opijnen (Somerville, Massachusetts); Juan C. Ortiz-Marquez (Brighton, Massachusetts); Stephen Hummel (Ft. Myers, Florida); José Bento (Medfield, Massachusetts) |
| ABSTRACT | The present disclosure provides a novel approach, recomSELEX, that highly integrate mutually supportive recombination and computational methods for aptamer selection and identification. The recomSELEX approach comprises a recombinatorial SELEX platform for aptamer screening that exponentially increases the sequence space that is explored by incorporation of a DNA shuffling step that allows recombination between aptamers. Subsequently, the recombinatorial SELEX platform can also be employed to develop new and optimize already existing aptamers. The recomSELEX further comprises a computational SELEX platform with a constrained genetic algorithm (GA) to identify potential aptamers that are stable and have the desired specificity and affinity of a target. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827240 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1048 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389409 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Tongtong Zhao (Cambridge, Massachusetts); Fei Chen (Cambridge, Massachusetts); Jason Buenrostro (Cambridge, Massachusetts); Evan Macosko (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for assessing relative DNA levels (e.g., levels of genomic DNA, mtDNA, viral DNA, bacterial DNA, etc.) in a spatially-defined manner across a tissue sample, specifically providing DNA sequence identity and relative abundance information at high-resolution across multiple locations assessed across the tissue sample. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/775471 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389415 | SALIT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standford, California); THE GOVERNMENT OF THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc SALIT (Gaithersburg, Maryland); Lars M. STEINMETZ (Stanford, California); Robert St. ONGE (Stanford, California); Justin D. SMITH (Stanford, California); Kevin ROY (Gaithersburg, Maryland) |
| ABSTRACT | Described herein are methods for making genetically modified cells by introducing combinations of genetic variants (designed or random) or constructs (genes or otherwise arbitrary DNA) into a population of cells, and for tracking each variant combination by sequentially building an array of barcodes at a common locus (chromosomal or plasmid), termed the barcode locus. Also described are the cells made by such methods. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/429250 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/1065 (20130101) C12N 15/1093 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389451 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Michael Segel (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more endogenous retroviral elements for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more endogenous retroviral elements for forming a delivery vesicle may comprise two or more of a retroviral gag protein, a retroviral envelope protein, a retroviral reverse transcriptase or a combination thereof. The retroviral gag protein alone, the retroviral envelope protein alone, or both the retroviral gag protein and retroviral envelope protein may be endogenous. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761641 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 2319/735 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2740/10022 (20130101) C12N 2740/10023 (20130101) C12N 2740/10042 (20130101) C12N 2740/13023 (20130101) C12N 2740/13042 (20130101) C12N 2740/14022 (20130101) C12N 2740/14023 (20130101) C12N 2740/14042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389502 | Lindsay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (Phoenix, Arizona); Eathen Ryan (Tempe, Arizona); Bintian Zhang (Tempe, Arizona); Xu Wang (Tempe, Arizona) |
| ABSTRACT | The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure relates to methods for sequencing a polynucleotide using a bioelectronic device that includes protein assemblies used as coupling molecules in bioelectronic circuits. The present disclosure also provides multimeric protein assemblies with various combinations of live and dead subunits arranged to maximize conduction. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832316 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389505 | Bharti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Kapil Bharti (Potomac, Maryland); Janine Davis (Baltimore, Maryland); Arvydas Maminishkis (Washington, District of Columbia); Marc Ferrer-Alegre (Potomac, Maryland); Sheldon S. Miller (Bethesda, Maryland) |
| ABSTRACT | High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812915 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 2501/16 (20130101) C12N 2501/41 (20130101) C12N 2501/115 (20130101) C12N 2501/415 (20130101) C12N 2501/999 (20130101) C12N 2506/45 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389509 | Anton et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raymond F. Anton (Charleston, South Carolina); Joseph P. Schacht (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond F. Anton (Charleston, South Carolina); Joseph P. Schacht (Denver, Colorado) |
| ABSTRACT | Disclosed are method for predicting naltrexone response in subjects with AUD. In some embodiments, the methods include performing or having performed one or more methylation assays on a genomic DNA sample isolated from the subject to determine the methylation status of one or more regions of the isolated genomic DNA, wherein the one or more regions are subsequences of a gene selected from a mu opioid receptor (OPRM1) gene, a catechol-O-methyltransferase (COMT) gene, and a dopamine transporter (SLC6A3) gene, wherein the methylation status of the one or more regions of the isolated genomic DNA determined is predictive of naltrexone response in the subject. Also provided are method for treating patients diagnosed with AUD with the medication naltrexone based on a methylation status of a combination of specific methylation sites located associated with an OPRM1 gene, a COMT gene, and/or an SLC6A3 gene in obtained from each AUD patient. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/824784 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389518 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Tuesday, August 16, 2022 |
| APPL NO | 17/820200 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) G16B 20/20 (20190201) G16B 30/00 (20190201) G16B 30/10 (20190201) G16B 35/20 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390369 | Piestun et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Sorbonne Université (Paris, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael Piestun (Boulder, Colorado); Kristina Irsch (Paris, France); Simon Labouesse (Boulder, Colorado); Sylvain Gigan (Paris, France) |
| ABSTRACT | Systems and methods are provided for imaging and characterizing objects including the eye using non-uniform or speckle illumination patterns. According to the present technology, a method for characterizing at least a portion of an object may include generating, using at least one light source, one or multiple non-uniform illumination patterns on an object. The method may also include detecting, using a detector, backscattered light from the object in response to the generating. The method may further include extracting, using the detector, data representative of the backscattered light. The method may also include processing, using a processing unit, the data representative of the backscattered light to create one or more images of at least a portion of the object. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/765364 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) A61B 5/0084 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) Original (OR) Class G01N 21/6456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390432 | Young et al. |
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| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Ann Boija (Somerville, Massachusetts); Isaac Klein (Milton, Massachusetts) |
| ABSTRACT | Described herein are methods of characterizing agent incorporation into condensates, methods of reducing transcription of oncogenes associated with condensates, and methods of using peptides to inhibit nuclear receptor and cofactor binding in condensates. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611560 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390456 | NAORA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Honami NAORA (Houston, Texas); Song Yi KO (Houston, Texas) |
| ABSTRACT | Provided herein are methods for predicting whether a cancer patient will respond to treatment with bevacizumab based on determining a level of small extracellular vesicle (sEV)-associated VEGF in the patient. Also provided are methods of treating patients with either bevacizumab or a VEGFR tyrosine kinase inhibitor, a VEGFR neutralizing antibody, or a VEGF ligand trap based on the level of small extracellular vesicle (sEV)-associated VEGF in the patient. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/769826 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/22 (20130101) C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/57488 (20130101) Original (OR) Class G01N 2333/475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390467 | Wong et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| INVENTOR(S) | Hector R. Wong (Cincinnati, Ohio); Natalja Stanski (Cincinnati, Ohio) |
| ABSTRACT | The disclosure provides methods for determining whether a sepsis patient is likely to develop severe sepsis associated acute kidney injury (SA-AKI) using a combination of clinical data and biomarker data obtained during the first 24 hours following the subject's diagnosis with sepsis. The methods described here are useful for preventing SA-AKI in at-risk patients as well as for point-of-care clinical decision support and stratifying septic shock patients for clinical trials. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/772004 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/26 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390474 | Karamichos |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dimitrios Karamichos (Carrollton, Texas) |
| ABSTRACT | The present invention includes a method for detecting or predicting a disease or condition related to a ratio of luteinizing hormone to follicle-stimulating hormone (LH/FSH ratio) comprising: obtaining or having obtained a biological sample from a subject; and determining the LH/FSH ratio in the biological sample, wherein a decrease in the LH/FSH ratio when compared to an age-matched subject that does not have a disease or condition of LH/FSH is indicative of a current or future disease or condition of LH/FSH. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/775040 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/76 (20130101) Original (OR) Class G01N 2333/59 (20130101) G01N 2800/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390895 | Potcoava et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois); THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mariana Camelia Potcoava (Lakewood, Colorado); Simon Trevor Alford (Chicago, Illinois); Christopher John Mann (Flagstaff, Arizona); Jonathan James Art (Chicago, Illinois) |
| ABSTRACT | A method and system for performing incoherent color holographic microscopy imaging using light of various wavelengths, including modulating radiation at each wavelength to form two beams and detecting their intensity at a detector. The two beams include phase information that is retrieved from the phase shifted intensity recorded at the detector and holographic information is determined from the detected modulation of the two beams for each color. A processor is configured to receive the holographic information via a signal generated by the detector and the processor further generates a three-dimensional image of a target. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883325 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/06 (20130101) Original (OR) Class G03H 1/12 (20130101) G03H 2001/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391553 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jiansong Zhang (Lafayette, Indiana); Temitope Akanbi (Windsor, Canada) |
| ABSTRACT | A method of generating a three-dimensional (3D) structure model from a two-dimensional (2D) drawing file, which includes one or more illustrations of a structure, using a data processing device includes importing the 2D drawing file to the data processing device, converting the 2D drawing file into a raster graphics file, converting the raster graphics file into a vector graphics file, extracting one or more graphical projections representative of the structure from the vector graphics file, converting the one or more projections into a tagged data graphics file, forming a 3D structure model representative of the structure by connecting the plurality of cartesian points of the tagged data graphics file, and generating an electronic output file including the 3D structure model. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832771 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Original (OR) Class G06F 30/23 (20200101) Image Data Processing or Generation, in General G06T 17/205 (20130101) G06T 19/20 (20130101) G06T 2219/2004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392070 | BUCKLER |
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| FUNDED BY |
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| APPLICANT(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | ELUCID BIOIMAGING INC. (Boston, Massachusetts) |
| INVENTOR(S) | Andrew J. BUCKLER (Boston, Massachusetts) |
| ABSTRACT | A system including a hierarchical analytics framework that can utilize a first set of machine learned algorithms to identify and quantify a set of biological properties utilizing medical imaging data is provided. System can segment the medical imaging data based on the quantified biological properties to delineate existence of perivascular adipose tissue. The system can also segment the medical imaging data based on the quantified biological properties to determine a lumen boundary and/or determine a cap thickness based on a minimum distance between the lumen boundary and LRNC regions. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890822 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02007 (20130101) A61B 6/504 (20130101) A61B 8/0891 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392215 | XIAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangming XIAO (Norman, Oklahoma); Jie WANG (Norman, Oklahoma) |
| ABSTRACT | A computer system having a processor executing a set of instructions that cause the processor to receive first image data having pixel information of a geographic region; calculate for particular real-world locations within the geographic region, a plurality of vegetation indices with combinations of the pixel information; generate a land cover mask with the vegetation indices, the land cover mask identifying first real-world locations within the geographic region having a water-related land cover type, a non-vegetated land cover type and an evergreen land cover type; classify second real-world locations within the geographic region that are not classified as the water-related land cover type, the non-vegetated land cover type and the evergreen land cover type as cropland; and analyze a time-series of image data depicting the second real-world locations within the geographic region with phenology metrics to identify at least one particular type of cropland within the second real-world locations. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828539 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/10024 (20130101) G06T 2207/10048 (20130101) G06T 2207/20081 (20130101) G06T 2207/30188 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/56 (20220101) G06V 10/764 (20220101) G06V 20/188 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392482 | Mesgarani et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nima Mesgarani (New York, New York); Yi Luo (New York, New York); James O'Sullivan (New York, New York); Zhuo Chen (New York, New York) |
| ABSTRACT | Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated). |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826474 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/318 (20210101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/26 (20130101) G10L 25/30 (20130101) Original (OR) Class G10L 25/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392564 | Ghiassian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Ghiassian (Boston, Massachusetts); Jörg Menche (Vienna, Austria); Amitabh Sharma (Boston, Massachusetts); Albert-László Barábasi (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure discusses a system and method for disease module detection. More particularly, a protein network and list of seed proteins are provided to the system. The system iteratively selects one or more candidate proteins for inclusion in the list of seed proteins. The system calculates a connectivity factor for each of the connections of the candidate proteins to proteins listed as seed proteins. Responsive to the calculated connectivity factors the system adds one or more of the candidate proteins to list of seed proteins. At the end of the iterative process the list of seed proteins can be indicative of the disease module. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812954 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) Original (OR) Class G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392579 | Berger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael F. Berger (New York, New York); Barry S. Taylor (New York, New York); Alexander Penson (New York, New York); Niedzica Camacho (New York, New York) |
| ABSTRACT | Disclosed are systems and methods for using genomic features revealed by clinical targeted tumor sequencing to predict of tissue of origin. Using machine learning techniques, an algorithmic classifier is constructed and trained on a large cohort of prospectively sequenced tumors to predict cancer type and origin from DNA sequence data obtained at the point of care. Genome-directed reassessment of classifications may prompt tumor type reclassification resulting in altered cancer therapy. The clinical implementation of artificial intelligence to guide tumor type classifications at the point of care can complement standard histopathology and imaging to enable improved classification accuracy. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/776498 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/00 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392581 | Califano et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrea Califano (New York, New York); Mukesh Bansal (New York, New York); Yishai Shimoni (New York, New York) |
| ABSTRACT | Techniques to identify a mechanism of action of a compound using network dysregulation are disclosed herein. An example method can include selecting at least a first interaction involving at least a first gene, determining a first n-dimensional probability density of gene expression levels for the first gene and one or more genes in a control state, determining a second n-dimensional probability density of gene expression levels for the first gene and one or more genes following treatment using at least one compound, estimating changes between the first probability density and the second probability density, and determining whether the estimated changes are statistically significant. |
| FILED | Monday, April 11, 2022 |
| APPL NO | 17/718255 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) G16B 35/00 (20190201) G16B 40/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/10 (20190201) Original (OR) Class G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392605 | Kurtz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustes of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustes of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Carlos, California); Arash Ash Alizadeh (San Mateo, California); Maximilian Diehn (San Carlos, California); Mohammad Shahrokh Esfahani (Mountain View, California) |
| ABSTRACT | Methods of treatment based on a prognosis as determined utilizing a Bayesian framework are provided. Clinical data is utilized within a Bayesian framework to obtain a prognosis of a medical disorder. A prognosis can be updated utilizing a Bayesian framework when subsequent clinical data is acquired, such as clinical data acquired during a treatment or clinical monitoring. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/646621 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) Original (OR) Class G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392651 | Meier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric T. Meier (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Uri Shumlak (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827396 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class G21B 1/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394838 | Shumlak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Eric T. Meier (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827379 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394839 | Shumlak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Eric T. Meier (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841591 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class H05H 1/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394840 | Meier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric T. Meier (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Uri Shumlak (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841593 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220386714 | Kartalov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emil Paskalev Kartalov (Pacific Grove, California) |
| ABSTRACT | A segmented diving suit includes a base layer and a plurality of composite plates arranged on the base layer in a configuration designed to avoid joints or other anatomical features that bend. The composite plates include a spheres or microspheres dispersed/embedded in a carrier polymer. The spheres or microspheres provide one or more of thermal protection, sonic/blast resistance, and ballistic protection. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828595 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/012 (20130101) A41D 13/015 (20130101) Original (OR) Class Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 25/02 (20130101) B32B 25/20 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) B33Y 80/00 (20141201) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 7/18 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) C09D 7/70 (20180101) C09D 183/04 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386967 | Pappada et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aptima, Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Aptima, Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | Scott M. Pappada (Waterville, Ohio); John J. Feeney (Beavercreek, Ohio); William N. DePriest (Dayton, Ohio) |
| ABSTRACT | Systems and methods for supporting medical therapy decisions are disclosed that utilize predictive models and electronic medical records (EMR) data to provide predictions of health conditions over varying time horizons. Embodiments also determine a 0-100 health risk index value that represents the “risk” for a patient to acquire a health condition based on a combination of real-time and predicted EMR data. The systems and methods receive EMR data and use the predictive models to predict one or more data values from the EMR data as diagnostic criteria. In some embodiments, the health condition trying to be avoided is Sepsis and the health risk index is a Sepsis Risk Index (SRI). In some embodiments, the predictive models are neural network models such as time delay neural networks. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819664 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/412 (20130101) A61B 5/02055 (20130101) A61B 5/7275 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387320 | EBER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CureVac AG (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac AG (Tübingen, Germany) |
| INVENTOR(S) | Fabian Johannes EBER (Stuttgart, Germany); Benyamin YAZDAN PANAH (Tübingen, Germany); Stefanie SEWING (Tübingen, Germany); Thomas KETTERER (Gomaringen, Germany); Thorsten MUTZKE (Reutlingen, Germany); Tilmann ROOS (Kusterdingen, Germany); Michael SONNTAG (Tübingen, Germany); Michael WIGGENHORN (München, Germany); Katharina KOLLAND (Augsburg, Germany) |
| ABSTRACT | The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule. |
| FILED | Monday, July 11, 2022 |
| APPL NO | 17/811808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) Original (OR) Class A61K 9/1682 (20130101) A61K 39/145 (20130101) A61K 48/00 (20130101) A61K 48/005 (20130101) A61K 48/0091 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) A61P 31/04 (20180101) A61P 31/12 (20180101) A61P 33/02 (20180101) A61P 35/00 (20180101) A61P 37/06 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387412 | Rangnekar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek M. Rangnekar (Nicholasville, Kentucky); David S. Watt (Lexington, Kentucky); Ravshan Burikhanov (Lexington, Kentucky); Vitaliy Sviripa (Lexington, Kentucky) |
| ABSTRACT | A composition and method for treating tumor cells are provided. The composition includes at least one ebastine derivative having a structure according to Formula I. The method include administering, to a patient in need thereof, an effective amount of the composition including at least one ebastine derivative having the structure according to Formula I. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/770267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/45 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387416 | RADOMSKY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CMC Pharmaceuticals, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Lloyd RADOMSKY (Chagrin Falls, Ohio); Donald DUWE (Strongsville, Ohio) |
| ABSTRACT | This disclosure relates to stable formulations of atropine and scopolamine for use as a medical countermeasure to combat organophosphate nerve agent threats. The formulations exploit complementary pharmacological profiles for optimal receptor blockade and anticholinergic activity within the peripheral and central nervous system. The formulations are suitable for intramuscular injection, and have stability that exceeds two years in stressed conditions. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/755055 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/46 (20130101) Original (OR) Class A61K 31/55 (20130101) A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387478 | MANGINO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin J. MANGINO (RICHMOND, Virginia); Loren K. LIEBRECHT (RICHMOND, Virginia) |
| ABSTRACT | A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/761792 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 31/765 (20130101) Original (OR) Class A61K 47/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387483 | HILL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FARADAY PHARMACEUTICALS, INC. (Seattle, Washington); FRED HUTCHINSON CANCER CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen A. HILL (Seattle, Washington); Michael Andrew INSKO (Seattle, Washington); Michael L. MORRISON (Seattle, Washington); Akiko IWATA (Seattle, Washington); Mark B. ROTH (Seattle, Washington) |
| ABSTRACT | The present invention relates to the use of iodide compounds, to treat and prevent cachexia and cardiotoxicity resulting from treatment with an anti-cancer therapy. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/774099 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/7048 (20130101) A61K 33/18 (20130101) Original (OR) Class A61K 33/243 (20190101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387589 | Gainer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diffusion Pharmaceuticals LLC (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John L. Gainer (Charlottesville, Virginia); Marc Lanz (Reitnau, Switzerland) |
| ABSTRACT | The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 31/11 (20130101) A61K 31/202 (20130101) A61K 41/0038 (20130101) Original (OR) Class A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Acyclic or Carbocyclic Compounds C07C 57/03 (20130101) C07C 57/13 (20130101) C07C 69/602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387626 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi CHEN (Milford, Connecticut); Guangchuan WANG (West Haven, Connecticut); Ryan D. CHOW (San Jose, California); Feifei ZHANG (New Haven, Connecticut) |
| ABSTRACT | The present invention includes compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/771202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 38/195 (20130101) A61K 38/1774 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) C12N 15/1082 (20130101) C12N 2310/20 (20170501) C12N 2710/10343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387666 | FRANCIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMBODY, INC. (Norfolk, Virginia) |
| ASSIGNEE(S) | EMBODY, INC. (Norfolk, Virginia) |
| INVENTOR(S) | Michael FRANCIS (Norfolk, Virginia); Nathan Kemper (Norfolk, Virginia); Hilary Wriggers (Norfolk, Virginia) |
| ABSTRACT | Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries. |
| FILED | Wednesday, April 20, 2022 |
| APPL NO | 17/724650 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 38/39 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/24 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2300/64 (20130101) A61L 2300/604 (20130101) A61L 2400/12 (20130101) A61L 2430/10 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387961 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Micah J. Green (College Station, Texas); Naveen K. Mishra (College Station, Texas); Nutan S. Patil (College Station, Texas); Benjamin A. Wilhite (College Station, Texas) |
| ABSTRACT | A method for chemical production includes applying electromagnetic heating to a composition that includes a catalytic component and an electromagnetic susceptor. Responsive to application of radio frequency energy, the electromagnetic susceptor causes the catalytic component to become heated. The heated electromagnetic susceptor and catalytic component interact with a chemical to form a product. |
| FILED | Wednesday, September 16, 2020 |
| APPL NO | 17/642045 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/129 (20130101) Original (OR) Class B01J 35/0033 (20130101) B01J 2208/00469 (20130101) B01J 2219/00716 (20130101) B01J 2219/00858 (20130101) B01J 2219/0892 (20130101) B01J 2219/00948 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387962 | Ramezani |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ODH IP Corp. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahdi Ramezani (Rockville, Maryland) |
| ABSTRACT | Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor. |
| FILED | Monday, March 28, 2022 |
| APPL NO | 17/706441 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0073 (20130101) B01J 19/248 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388026 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Jiwoong Park (Chicago, Illinois); Yu Zhong (Chicago, Illinois); Baorui Cheng (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are inventive methods of making thin films, inventive thin films, and inventive articles and systems comprising thin films. Certain embodiments are related to methods of making thin films in which reagents are arranged within a first phase and a second phase such that at least one reagent reacts to form a thin film proximate to the interface between the first phase and the second phase. Thin films (including two-dimensional materials) disclosed herein can have one or more of a variety of beneficial properties including large lateral dimension(s), lateral continuity, high mechanical strength, consistent spatial composition, and/or consistent thickness. In accordance with certain embodiments, thin films disclosed herein can be combined to form a variety of inventive multi-layer articles, including multi-layer articles comprising a combination of thin films having different compositions that interact with each other via van der Waals forces. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/767125 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/20 (20130101) B05D 1/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388150 | Sugar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Thomas Sugar (Chandler, Arizona); Kevin Hollander (Scottsdale, Arizona) |
| ABSTRACT | A hip assist actuation system is configured to allow a user to experience free movement of hip extension and hip flexion over a predetermined range and receive a torque assist in response to performing a lifting or pushing activity. The hip assist actuation system may be configured to determine whether the lifting or pushing activity is occurring and provide the torque assist in response to the determination. |
| FILED | Wednesday, August 10, 2022 |
| APPL NO | 17/885433 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388222 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson, AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); David H. Wang (Beavercreek, Ohio); Zhenning Yu (Beavercreek, Ohio) |
| ABSTRACT | The invention generally relates to shape memory films that are tri-functionally crosslinked and that comprise multiple, non-terminal, phenylethynyl moieties. In addition, the present invention relates methods of fabricating such films. Due to the improved properties of such SMPs, the SMP designer can program in to the SMP thermomechanical property enhancements that make the SMP suitable, among other things, for advanced sensors, high temperature actuators, responder matrix materials and heat responsive packaging. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/869926 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/02 (20130101) B29C 41/02 (20130101) B29C 41/003 (20130101) B29C 41/12 (20130101) B29C 41/42 (20130101) B29C 41/46 (20130101) B29C 53/04 (20130101) B29C 53/005 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/24 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/14 (20130101) C08G 73/101 (20130101) C08G 73/121 (20130101) C08G 73/124 (20130101) C08G 73/1067 (20130101) C08G 73/1071 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388223 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); David H. Wang (Beavercreek, Ohio) |
| ABSTRACT | The invention generally relates to shape memory films that are tri-functionally crosslinked and that comprise multiple, non-terminal, phenylethynyl moieties. In addition, the present invention relates methods of fabricating such films. Due to the improved properties of such SMPS, the SMP designer can program in to the SMP mechanical property enhancements that make the SMP suitable, among other things, for advanced sensors, high temperature actuators, responder matrix materials and heat responsive packaging. |
| FILED | Thursday, July 21, 2022 |
| APPL NO | 17/869927 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/02 (20130101) B29C 41/02 (20130101) B29C 41/003 (20130101) B29C 41/12 (20130101) B29C 41/42 (20130101) B29C 41/46 (20130101) B29C 53/04 (20130101) B29C 53/005 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0061 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/14 (20130101) C08G 73/101 (20130101) C08G 73/121 (20130101) C08G 73/124 (20130101) C08G 73/1067 (20130101) C08G 73/1071 (20130101) C08G 2220/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388241 | Yelinek |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Yelinek (Mechanicsville, Maryland) |
| ABSTRACT | An apparatus and method to magnetically align fibers in a base additive material during an additive manufacturing process for material property enhancing purposes or to facilitate joining of multiple types of materials during the additive process to form an integrated part. The magnetically alignable fibers are positioned through the application of a controlled, multi-axis positioning magnetic field during the additive-material layer deposition phase. This allows the fibers to be embedded within the base additive-material in any three-dimensional desired orientation, and the orientation to be varied from layer to layer, to permit directional enhancement of material properties, dependent on the nature of the fiber materials themselves. Likewise, joining of multiple types of materials may be improved through the controlled deposition of such fibers embedded within the base material itself during the additive-process between layers of two or more dissimilar materials, to provide a directionally aligned mechanical attachment between layers of base additive materials to result in a strengthened consolidated part at the conclusion of the additive manufacturing process. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337469 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/10 (20210101) B22F 10/50 (20210101) B22F 10/85 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) B29C 64/194 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388277 | Al-Haik |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Embry-Riddle Aeronautical University, Inc. (Daytona Beach, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marwan Al-Haik (Port Orange, Florida) |
| ABSTRACT | A reinforced carbon composite can include a carbon substrate and a metal organic framework bonded to the carbon substrate. For example, a reinforced carbon composite can include a first layer, a second layer, and a resin adhered to the first layer and the second layer. The first layer can include a carbon substrate and a metal organic framework bonded to the carbon substrate. The second layer can include a carbon substrate and a metal organic framework bonded to the carbon substrate. |
| FILED | Wednesday, March 02, 2022 |
| APPL NO | 17/685003 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/024 (20130101) B32B 7/12 (20130101) B32B 9/045 (20130101) Original (OR) Class B32B 37/12 (20130101) B32B 2262/106 (20130101) B32B 2305/188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388643 | PREISS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| INVENTOR(S) | Yair PREISS (Norwalk, Connecticut); Bradley M. BAUER (Fort Worth, Texas) |
| ABSTRACT | A rotatable swashplate is rotatable relative to a stationary swashplate around a shaft and connects to a pitch control rod assembly. The rotatable swashplate includes an upper portion and a lower portion. The upper portion is extendable outside of a stationary swashplate and includes a plurality of lugs each configured to attach to a pitch control rod assembly, an innermost wall configured to receive a shaft, and a membrane. The lower portion is positionable within the stationary swashplate and has an outermost wall and at least one extension extending radially between the outermost wall and the innermost wall. The membrane extends radially over the at least one extension. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337719 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/10 (20130101) B64C 27/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388652 | Hefner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Levi Charles Hefner (Dallas, Texas); Dakota Charles Easley (Dallas, Texas) |
| ABSTRACT | An unmanned aircraft system operable for wing-borne lift in a flying wing orientation. The unmanned aircraft system includes an airframe having a leading edge, a trailing edge, first and second wingtips and a root chord. The airframe has an airfoil cross-section along chord stations thereof. A thrust array is coupled to the airframe including first and second motor mounts coupled to the leading edge respectively between the root chord and the first and second wingtips. The motor mounts each have first and second propulsion assemblies coupled to respective first and second distal ends thereof. The motor mounts each have a flight configuration substantially perpendicular with the leading edge forming a two-dimensional distributed thrust array such that the airframe extends outboard of the first and second motor mounts. The unmanned aircraft system includes an electric power system and a flight control system that are operably associated with the thrust array. |
| FILED | Tuesday, April 05, 2022 |
| APPL NO | 17/714096 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/46 (20130101) B64C 29/02 (20130101) B64C 39/024 (20130101) Original (OR) Class B64C 2201/20 (20130101) B64C 2201/024 (20130101) B64C 2201/028 (20130101) B64C 2201/042 (20130101) B64C 2201/108 (20130101) B64C 2201/141 (20130101) B64C 2201/146 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/26 (20130101) B64D 2027/262 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388856 | Grady et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zane Michael Grady (University Park, Pennsylvania); Arnaud Ndayishimiye (University Park, Pennsylvania); Clive A. Randall (University Park, Pennsylvania) |
| ABSTRACT | Embodiments relate to a method for fabricating a sintered sodium-ion material. The method involves mixing a parent phase sodium-ion compound with a secondary transient phase to form a powder mixture. The method involves applying pressure and heat above a melting point or boiling point of the secondary transient phase to drive dissolution at particle contacts and subsequent precipitation at newly formed grain boundaries. The method involves generating a sintered sodium-ion material with >90% relative density. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/656587 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/028 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/10 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0407 (20130101) H01M 10/0562 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389028 | Matsuyama et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shigemi Matsuyama (Cleveland, Ohio); William Greenlee (Cleveland, Ohio) |
| ABSTRACT | A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 17/615377 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 13/28 (20130101) Heterocyclic Compounds C07D 403/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 491/048 (20130101) C07D 495/04 (20130101) Original (OR) Class C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389273 | Kidwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kidwell (Alexandria, Virginia); Thomas O'Shaughnessy (Arlington, Virginia) |
| ABSTRACT | A mixed acrylate-siloxane polymer can be used to create three-dimensional (3D) structures of arbitrary shape via nanolithography. Treatment of such structures with amine (such as diamine) makes them permissive for neuronal cell adhesion and growth without need of additional modification such as poly-lysine (D or L) nor laminin. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/888009 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/32 (20130101) C03C 2218/32 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 133/08 (20130101) C09D 183/04 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389316 | Yao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tianyi Yao (Exton, Pennsylvania); Kathleen J Stebe (Penn Valley, Pennsylvania) |
| ABSTRACT | Provided are compositions that include a nematic colloid, the nematic colloid comprising a nematic liquid crystal and a key colloid; and a lock colloid, the lock colloid optionally having at least two arms extending therefrom, the lock colloid being configured for assembly with the key colloid of the nematic colloid, the assembly optionally being mediated by a dipole interaction between the colloid and the lock colloid, by a disinclination line of the nematic colloid, or any combination thereof. Also provided are related methods. The disclosed compositions and methods can be used to, e.g., assemble chain and lattice structures from the key colloids by exploiting disinclination lines and dipole defects of the components of the compositions. |
| FILED | Wednesday, May 25, 2022 |
| APPL NO | 17/664911 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/0208 (20130101) Original (OR) Class C09K 2323/031 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389414 | ASPURU-GUZIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada); WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin); THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (Glasgow, United Kingdom); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan ASPURU-GUZIK (Toronto, Canada); Si Yue GUO (Toronto, Canada); Tony Chang-Chi WU (Toronto, Canada); Pascal Thomas FRIEDERICH (Karlsruhe, Germany); Randall Howard GOLDSMITH (Madison, Wisconsin); Leroy CRONIN (Glasgow, United Kingdom); Abhishek SHARMA (Glasgow, United Kingdom); Yudong CAO (Cambridge, Massachusetts); Nathan C. GIANNESCHI (Wilmette, Illinois); Christopher James FORMAN (Chicago, Illinois) |
| ABSTRACT | Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/772169 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) G06N 99/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390192 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Liping Wang (Chandler, Arizona); Payam Sabbaghi (Tempe, Arizona); Linshuang Long (Hefei, China PRC) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Liping Wang (Chandler, Arizona); Payam Sabbaghi (Tempe, Arizona); Linshuang Long (Hefei, China PRC) |
| ABSTRACT | A composite thermal dissipator and a method for fabricating the same is disclosed. The composite thermal dissipator includes a molded polydimethylsiloxane (PDMS) composite material composed of a powdered metal mixed with PDMS. The method for fabricating a composite thermal dissipator includes mixing a powdered copper into liquid PDMS to form a liquid mixture, and pouring the liquid mixture into a sacrificial wax mold. The sacrificial wax mold includes wax shaped to be complementary to the composite thermal dissipator. The method also includes curing the liquid mixture within the sacrificial wax mold, and removing the composite thermal dissipator from the sacrificial wax mold by melting away the wax. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835660 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) B22F 1/145 (20220101) B22F 7/08 (20130101) B22F 2301/10 (20130101) B22F 2304/10 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/04 (20130101) F28F 21/085 (20130101) Original (OR) Class F28F 2255/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390218 | Goss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AURA Technologies, LLC (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garrett Goss (Cary, North Carolina); Alex Blate (Raleigh, North Carolina) |
| ABSTRACT | Fuze assembly systems, devices, and methods. The fuze assembly includes a baseplate; a first gear operably connected to the baseplate and rotatable about a fixed axis between a safety position and an armed position; and a retention device configured to retain the first gear in the safety position and enable rotation of the first gear while being subject to a centrifugal force above a first threshold from rotation of the assembly. The fuze assembly further includes a second gear in operable contact with the first gear and configured to move along a path of the baseplate due to the centrifugal force to rotate the first gear from the safety position to the armed position. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832004 |
| CURRENT CPC | Ammunition Fuzes; Arming or Safety Means Therefor F42C 15/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390219 | Goss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AURA Technologies, LLC (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garrett Goss (Cary, North Carolina); Alex Blate (Raleigh, North Carolina) |
| ABSTRACT | Fuze assembly methods and devices. The methods include providing a firing pin to detonate the projectile; operably connecting a weighted body to the firing pin; and operably connecting a flexural portion to the weighted body to retain position of the weighted body due to centrifugal force generated by the rotation of the projectile to retain the firing pin in a detonation prevention position and move the weighted body to drive the firing pin to a detonation position upon impact of the projectile. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832012 |
| CURRENT CPC | Ammunition Fuzes; Arming or Safety Means Therefor F42C 1/04 (20130101) F42C 15/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390480 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dzung Minh Duc Tran (Tampa, Florida); Tansel Yucelen (Tampa, Florida); Selahattin Burak Sarsilmaz (Tampa, Florida) |
| ABSTRACT | Systems and methods are described for estimating a state of a process and an input to the process using a sensor network. Each sensor node in the sensor network is directly to one or more adjacent sensor nodes and indirectly coupled to the remaining sensor nodes through the one or more adjacent sensor nodes. Each sensor node iteratively calculates a new estimated state based on estimations of the state and the input to the process calculated by the sensor node in a previous iteration. The new estimated state is then adjusted based on a difference between a predicted and actual output of a sensor and is further adjusted based on differences between a previous estimated state calculated by the sensor node and estimated states calculated by adjacent sensor nodes. |
| FILED | Monday, August 01, 2022 |
| APPL NO | 17/878262 |
| CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390553 | Englesbe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Alexander C. Englesbe (Washington, District of Columbia); Jennifer A. Elle (Albuquerque, New Mexico); Andreas Schmitt-Sody (Albuquerque, New Mexico); Travis M. Garrett (Albuquerque, New Mexico) |
| ABSTRACT | A method for generating ultrawideband pulsed microwave signals from optical field ionization of a gas with an ultrashort laser pulse, where the amplitude and frequency of the signals can be controlled via the characteristics of the laser pulse and/or the gas. The center frequency of the spectrum of the microwave signal can be controlled by changing the laser pulse energy. The amplitude of the microwave signal can be controlled by changing the wavelength of the laser pulses. The amplitude and frequency of the microwave signal can be tuned by controlling the pressure of the gas medium. The location at which the microwave signal is generated can be controlled by controlling the location at which the laser pulse creates a plasma. Interference among microwave signals resulting from multiple laser-produced plasmas can be used to construct an ultrawideband microwave signal having a predetermined amplitude and frequency. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828095 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/282 (20130101) Original (OR) Class G01S 13/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390677 | Vitullo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dashiell L. Vitullo (Rockville, Maryland); Daniel E. Jones (Nottingham, Maryland); Michael Brodsky (Millburn, New Jersey); Michael Sumetsky (Birmingham, United Kingdom); Sajid Zaki (Birmingham, United Kingdom) |
| ABSTRACT | Various embodiments are directed to systems, apparatus and methods for characterizing evanescent coupling parameters of a waveguide coupled to a resonator through variation of their relative positions. Various embodiments extend a local coupling approach with novel fitting capabilities that robustly determine the bare resonator modes and coupling parameters with quantified residual error and coupling parameter uncertainty estimates. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890626 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/29341 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390694 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | Intel Corporation (Santa Clara, California) |
| INVENTOR(S) | Chia-Pin Chiu (Tempe, Arizona); Kaveh Hosseini (San Jose, California); Thu Ngoc Tran (Chandler, Arizona); Yew Fatt Kok (Newark, California); Kumar Abhishek Singh (Phoenix, Arizona); Xiaoqian Li (Chandler, Arizona); Marely Tejeda Ferrari (Tempe, Arizona); Ravindranath Mahajan (Chandler, Arizona); Kevin Ma (Beaverton, Oregon); Casey Thielen (Chandler, Arizona) |
| ABSTRACT | The removal of heat from silicon photonic integrated circuit devices is a significant issue in integrated circuit packages. As presented herein, the removal of heat may be facilitated with an optically compatible thermal interface structure on the silicon photonic integrated circuit device. These thermal interface structures may include stack-up designs, comprising an optical isolation structure and a thermal interface material, which reduces light coupling effects, while effectively conducting heat from the silicon photonic integrated circuit device to a heat dissipation device, thereby allowing effective management of the temperature of the silicon photonic integrated circuit device. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/338928 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) G02B 6/4206 (20130101) G02B 6/4268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390810 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clemson University (Clemson, South Carolina) |
| ASSIGNEE(S) | Clemson University (Clemson, South Carolina) |
| INVENTOR(S) | Eric G. Johnson (Clemson, South Carolina); Jerome Keith Miller (Clemson, South Carolina); Richard Watkins (Clemson, South Carolina); Kaitlyn Morgan (Clemson, South Carolina); Wenzhe Li (Clemson, South Carolina); Yuan Li (Clemson, South Carolina) |
| ABSTRACT | This system and method of for providing a tunable orbital angular momentum system for providing higher order Bessel beams comprising: an acousto-optical deflector configured to receive an input beam, deflect a first portion of the input beam a first deflection angle relative to an axis of propagation and along an optical axis and deflect a second portion of the input beam a second deflection angle relative to the optical axis; a line generator disposed along the optical angle for receiving the first portion and the second portion of the input beam and provide an elliptical Gaussian mean; a log-polar optics assembly disposed along the optical angle for receiving the elliptical Gaussian beam and wrapping the elliptical Gaussian beam with an asymmetric ring; and, a Fourier lens configured to receive the wrapped elliptical Gaussian beam. |
| FILED | Monday, June 13, 2022 |
| APPL NO | 17/838632 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/33 (20130101) Original (OR) Class Transmission H04B 10/27 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390960 | Seeley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (keyport, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Seeley (Seabeck, Washington); Nathan Schulyer (Silverdale, Washington); Jacob Yates (Poulsbo, Washington); Destany Burke (Bremerton, Washington); Colin Gillespie (Orem, Utah); Shawn Stainsby (Keyport, Washington); Stephen J. Leahu (Bremerton, Washington) |
| ABSTRACT | Systems and methods are provided for using an additively manufactured vehicle, such as an UUV, with additively manufactured modules. The vehicle may be configurable such that additively manufactured modules or components may be detachably connected to the vehicle by hand, without the use of tools. Such modules may include connectors adapted to securely attach additional modules that may be detached by hand, without the use of tools. The additively manufactured modules may include ball bearings for rotating modules such as propellers and thrusters, and clips or tabs for detachable connection. The modules may include optical components for communications between a swarm of unmanned vehicles. Such optical modules for underwater vehicles may utilize nephelometry and/or turbidimetry to improve communications parameters based on scattered light measurements. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/877622 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 1/00 (20130101) F16B 2001/0035 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390963 | Takahashi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United State of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | The United State of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Marc D Takahashi (Cupertino, California); Matthew S Whalley (Sunnyvale, California); Marcos G. Berrios (California, Maryland) |
| ABSTRACT | Systems and methods are disclosed to transport a common load attached by slings by two or more Vertical Take Off and Landing (VTOL) aircraft using synchronized maneuvering and load feedback control. In one embodiment, a system includes: a unit configured to direct the load operation with macro level commands input by a system operator; a unit, on each aircraft, configured to estimate its state; a unit configured to measure the sling load forces on each aircraft; a unit configured to release the load from the aircraft; a unit configured to allow all aircraft to share their load data and aircraft state data; a computing system on each aircraft with access to the shared data and the ability to control the aircraft control effectors and sling release mechanism; and a computing unit configured to execute a Guidance & Navigation system (or equivalent) and a Multi-Lift Autonomous Flight Control System (MLAFCS) with Multi-Lift Synchronized Maneuvering, Load Distribution Regulation, and Load Swing Feedback (or equivalent) on the aforementioned computing unit. |
| FILED | Friday, May 01, 2020 |
| APPL NO | 16/865301 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 29/0008 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/22 (20130101) B64D 47/00 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) G05D 1/102 (20130101) G05D 1/104 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391249 | Wagner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Wagner (Washington, District of Columbia); Paul Rademacher (Washington, District of Columbia) |
| ABSTRACT | Systems and methods are provided for cognitive resource scheduling for radar systems. Embodiments of the present disclosure demonstrate the implementation of a policy neural network to perform task scheduling, which offers superior performance to existing heuristic methods while maintaining feasible execution times to enable real-time implementation. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/830321 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4881 (20130101) Original (OR) Class G06F 9/5038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391421 | Skarin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aptima, Inc. (Woburn, Massachusetts) |
| ASSIGNEE(S) | Aptima, Inc. (Woburn, Massachusetts) |
| INVENTOR(S) | Bruce Skarin (Millbury, Massachusetts); Andrew Duchon (Portland, Oregon); Richard DeJordy (Stoughton, Massachusetts); Paul Allopenna (Storrs-Mansfield, Connecticut) |
| ABSTRACT | Embodiments of the subject invention comprise a computer based system and methods to collect and compare the attributes of a group of entities using data representing topic data of the entity and interaction data between entities. Embodiments of the invention comprise using minimally invasive means to automatically collect and model both an entity's attributes such as their knowledge/work/interest as well as model the social interactions of the entity together with a means to identify opportunities to influence changes in the entity attributes. Minimally invasive means to collect and model attributes include semantic analysis and topic modeling techniques. Means to model social interactions include social network analysis techniques that can incorporate location data of the entity. Embodiments of the invention further provide a sharable index of the attributes of the entities and the group of entities. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819651 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/288 (20190101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391708 | Kiarashinejad et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yashar Kiarashinejad (Atlanta, Georgia); Mohammadreza Zandehshahvar (Atlanta, Georgia); Sajjad Abdollahramezani (Atlanta, Georgia); Omid Hemmatyar (Atlanta, Georgia); Ali Adibi (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a system and method for identifying a first plurality of data points comprising a design space and a response space, the method including computing a first convex hull of all data points in the plurality of data points, merging the first convex hull with previous convex hulls to form an optimized convex hull, the previous convex hulls comprising a second plurality of data points comprising previous design spaces and previous response spaces, and determining, by the optimized convex hull, a feasible optical response performance within an electromagnetic nanostructure. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474523 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) Original (OR) Class G06N 3/0427 (20130101) G06N 3/0454 (20130101) G06N 20/10 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391743 | Wild et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominik S. Wild (Somerville, Massachusetts); Dries Sels (Allston, Massachusetts); Hannes Pichler (Concord, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts) |
| ABSTRACT | A system includes a quantum computer, and a computing node configured to: receive a description of a probability distribution, determine a first Hamiltonian having a ground state encoding the probability distribution, determine a second Hamiltonian, the second Hamiltonian being continuously transformable into the first Hamiltonian via a path through at least one quantum phase transition, and provide instructions to the quantum computer to: initialize a quantum system according to a ground state of the second Hamiltonian, and evolve the quantum system from the ground state of the second Hamiltonian to the ground state of the first Hamiltonian according to the path through the at least one quantum phase transition. The computing node is further configured to receive from the quantum computer a measurement on the quantum system, thereby obtaining a sample from the probability distribution. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858570 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392105 | Bramlett et al. |
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| FUNDED BY |
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| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Eric Bramlett (Gurley, Alabama); Michael Harris Rodgers (Huntsville, Alabama) |
| ABSTRACT | Search points in a search space may be projected onto images from cameras imaging different parts of the search space. Subimages, corresponding to the projected search points, may be selected and processed to determine if a target object has been detected. Based on subimages in which target objects are detected, as well as orientation data from cameras capturing images from which the subimages were selected, positions of the target objects in the search space may be determined. |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/715194 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 7/33 (20170101) G06T 7/70 (20170101) G06T 7/74 (20170101) Original (OR) Class G06T 7/80 (20170101) G06T 7/174 (20170101) G06T 7/246 (20170101) G06T 2207/10016 (20130101) G06T 2207/20021 (20130101) G06T 2207/20068 (20130101) G06T 2207/30212 (20130101) G06T 2207/30232 (20130101) G06T 2207/30244 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/255 (20220101) G06V 10/462 (20220101) G06V 10/751 (20220101) G06V 20/52 (20220101) G06V 20/60 (20220101) G06V 2201/07 (20220101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/23229 (20130101) H04N 5/23299 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392564 | Ghiassian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Ghiassian (Boston, Massachusetts); Jörg Menche (Vienna, Austria); Amitabh Sharma (Boston, Massachusetts); Albert-László Barábasi (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure discusses a system and method for disease module detection. More particularly, a protein network and list of seed proteins are provided to the system. The system iteratively selects one or more candidate proteins for inclusion in the list of seed proteins. The system calculates a connectivity factor for each of the connections of the candidate proteins to proteins listed as seed proteins. Responsive to the calculated connectivity factors the system adds one or more of the candidate proteins to list of seed proteins. At the end of the iterative process the list of seed proteins can be indicative of the disease module. |
| FILED | Friday, July 15, 2022 |
| APPL NO | 17/812954 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) Original (OR) Class G16B 35/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392576 | Baldwin |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AF, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | James C Baldwin (Huber Heights, Ohio) |
| ABSTRACT | A method of detecting and identifying pathogens in a sample comprising a plurality of genetic sequences. A plurality of electronic sequence reads corresponding to the plurality of genetic sequences is received and sampled to form a sample set. The sample set is iteratively and electronically compared to a plurality of pathogen sequences to create a detection group, which populates a putative genome data structure. A distance score is measured between each electronic sequence read of the sampled set to each pathogen sequence of the putative genome data structure. A hit score is calculated by comparing the distance score to a threshold value. A plurality of clusters of the electronic sequence reads of the sample set is formed to maximize the cluster hit score and to minimize a difference in distance scores of the cluster. A respective taxonomic group assigned to electronic reads of the sample set after clustering is displayed. |
| FILED | Friday, July 29, 2022 |
| APPL NO | 17/816169 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392893 | IYER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Subramanian IYER (Los Angeles, California); Kannan K. THANKAPPAN (Los Angeles, California); Boris VAISBAND (Los Angeles, California) |
| ABSTRACT | Two approaches for on-chip ESD detection include variable dielectric width capacitor, and vertical metal-oxide-semiconductor (MOS) capacitor MOSCAP array. The variable dielectric width capacitor approach employs metal plates terminated with sharp corners to enhance local electric field and facilitate ready breakdown of a thin dielectric between the metal plates. The vertical MOSCAP array is composed of a capacitor array connected in series. Both approaches are incorporated in an example 22 nm fully depleted silicon-on-insulator. Vertical MOSCAP arrays detect ESD events starting from about 6 V with about 6 V granularity, while the variable dielectric width capacitor is suitable for detection of high ESD voltage from about 40 V and above. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332931 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/002 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/01 (20130101) H01L 27/0805 (20130101) Original (OR) Class H01L 28/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220393056 — INVERTED METAMORPHIC MULTIJUNCTION SOLAR CELLS HAVING A PERMANENT SUPPORTING SUBSTRATE
| US 20220393056 | Cornfeld et al. |
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| FUNDED BY |
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| APPLICANT(S) | SOLAERO TECHNOLOGIES CORP. (ALBUQUERQUE, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur B. Cornfeld (Sandy Springs, Georgia); Jeff Steinfeldt (Rio Rancho, New Mexico) |
| ABSTRACT | A method of manufacturing a solar cell that includes providing a semiconductor growth substrate; depositing on said growth substrate a sequence of layers of semiconductor material forming a solar cell; applying a metal contact layer over said sequence of layers; affixing the adhesive polyimide surface of a permanent supporting substrate directly over said metal contact layer and permanently bonding it thereto by a thermocompressive technique; and removing the semiconductor growth substrate. |
| FILED | Wednesday, August 17, 2022 |
| APPL NO | 17/820509 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/048 (20130101) H01L 31/184 (20130101) H01L 31/0304 (20130101) H01L 31/0725 (20130101) Original (OR) Class H01L 31/1844 (20130101) H01L 31/1848 (20130101) H01L 31/1856 (20130101) H01L 31/1892 (20130101) H01L 31/03046 (20130101) H01L 31/03048 (20130101) H01L 31/06875 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/544 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393091 | HOUCK et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Priinceton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew HOUCK (Princeton, New Jersey); Nathalie DE LEON (Princeton, New Jersey); Robert Joseph CAVA (Princeton, New Jersey); Alex PLACE (Princeton, New Jersey); Lila RODGERS (Princeton, New Jersey); Sara SUSSMAN (Princeton, New Jersey); Mattias FITZPATRICK (Princeton, New Jersey); Basil SMITHAM (Princeton, New Jersey) |
| ABSTRACT | Methods, devices, and systems are described for forming a superconducting qubit. An example device may comprise a substrate having a first surface and a patterned layer adjacent the substrate and comprising tantalum in an alpha phase. The patterned layer may comprise at least a part of a structure for storing a quantum state. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/776078 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) H01L 39/2493 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393363 | Jornet et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Government of the United Stated as represented by the Secretary of the Air Force (Rome, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josep Miquel Jornet (Needham, Massachusetts); Arjun Singh (Southbridge, Massachusetts); Michael Andrello (Rome, New York); Erik Einarsson (Buffalo, New York); Ngwe Thawdar (Rome, New York) |
| ABSTRACT | A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/804446 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 15/148 (20130101) Original (OR) Class H01Q 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393431 | Gerhold et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael D. Gerhold (Raleigh, North Carolina); Alexander Franke (Raleigh, North Carolina); Zlatko Sitar (Apex, North Carolina); Ramon Collazo (Raleigh, North Carolina); Ronny Kirste (Durham, North Carolina); Dorian Alden (Raleigh, North Carolina) |
| ABSTRACT | A method of making a Group III nitride material that includes: providing a substrate; patterning a template on the substrate; depositing a layer of a material comprising aluminum, gallium and nitrogen on the substrate at a temperature; annealing the layer comprising aluminum, gallium and nitrogen; epitaxially growing Distributed Bragg Reflectors to form a structure on the substrate that comprises microcavities; and etching micropillars in the structure for at least 30 seconds with a heated basic solution is described. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832769 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) C30B 25/186 (20130101) C30B 29/403 (20130101) C30B 33/10 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393485 | Kamel Ahmed et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mohamed Ahmed Kamel Ahmed (Rochester, Michigan); Regan A. Zane (Hyde Park, Utah); Dragan Maksimovic (Boulder, Colorado) |
| ASSIGNEE(S) | Utah State University (Logan, Utah); University of Colorado Boulder (Boulder, Colorado) |
| INVENTOR(S) | Mohamed Ahmed Kamel Ahmed (Rochester, Michigan); Regan A. Zane (Hyde Park, Utah); Dragan Maksimovic (Boulder, Colorado) |
| ABSTRACT | An apparatus includes a battery pack with N battery bricks, each with a DC output voltage. The output of each brick is connected in series providing a bus voltage. Each brick includes battery power modules (“BPMs”) connected in parallel and each connected to a battery cell. Each BPM charges/discharges the connected battery cell. Each brick has a battery brick controller that provides a control signal to each brick's BPMs. A control signal of a BPM is derived from a BPM error signal that includes a battery cell current of the battery cell of BPM subtracted from a summation of an average current signal, a local droop current and a balancing current. The balancing current is based on a current SOC of the battery cell connected to the BPM and a desired SOC for the battery cell connected to the BPM. A BMS derives the balancing current for the BPMs. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529962 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/441 (20130101) H01M 10/482 (20130101) H01M 50/204 (20210101) H01M 50/509 (20210101) H01M 2010/4271 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0016 (20130101) Original (OR) Class H02J 7/0048 (20200101) H02J 7/00712 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393710 | Rachid |
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| FUNDED BY |
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| APPLICANT(S) | SILVUS TECHNOLOGIES, INC. (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansour Rachid (Los Angeles, California) |
| ABSTRACT | Certain disclosed embodiments pertain to suppressing interference in a wireless communication system. For example, a method of suppressing interference can include receiving one, two, or more first signals including components from a plurality of sub-channels. Each of the first signals can be processed by a Finite Impulse Response filter adapted using an LMS update algorithm, |
| FILED | Thursday, April 07, 2022 |
| APPL NO | 17/658415 |
| CURRENT CPC | Transmission H04B 1/0057 (20130101) H04B 1/0078 (20130101) H04B 1/0483 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393727 | Mirfarshbafan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); ETH ZURICH, The Swiss Federal Institute of Technology (Zurich, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyed Hadi Mirfarshbafan (Zurich, Switzerland); Christoph Studer (Zurich, Switzerland) |
| ABSTRACT | A wireless communication system can include an antenna and an equalization system. The antenna can be configured to wirelessly receive a data signal from a user equipment (UE). The equalization system can be configured to compensate for distortion incurred by the data signal during propagation. The equalization system can include a set of multiplier circuits. Each multiplier circuit can include a first input, a second input, a multiplier device, and a management circuit. The first input can receive a first input signal that corresponds to the data signal. The second input can receive a second input signal that corresponds to a weighting value assigned to a channel associated with the antenna. The multiplier device can be enabled or disabled. When enabled, the multiplier device can be configured to perform a multiplication operation on the first input signal and the second input signal. When disabled, the multiplier circuit may not perform the multiplication operation. The management circuit can be configured to selectively disable or enable the multiplier device based on the first input signal and/or the second input signal, thereby reducing an effective number of multiplications and offering power savings. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/830407 |
| CURRENT CPC | Transmission H04B 7/0452 (20130101) Original (OR) Class H04B 7/0456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394646 | Leneave et al. |
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| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Leneave (Idaho Falls, Idaho); Brett Joseph Steenblik (Vail, Arizona); David G. Manzi (Tucson, Arizona) |
| ABSTRACT | Apparatus and associated methods relate to providing robust synchronization of a Radio-Frequency (RF) communication in a severe-fading environment. A first portion of a detected RF signal is auto-correlated with a second portion of the detected RF signal. The first and second portions are time-separated by the predetermined time delay separating the first and second code-sequences. A third portion of the detected RF signal is sync-correlated with a sync-sequence so as to generate a sync-correlation signal. The third portion is of the predetermined length of the sync sequence and includes the first and second portions of the detected RF signal used to generate the auto-correlation signal. The auto-correlation signal is multiplied by the sync-correlation signal so as to generate a combined synchronization signal. A peak in the combined synchronization signal is then detected. This peak can be indicative of a synchronization time of an authorized communication. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339792 |
| CURRENT CPC | Wireless Communication Networks H04W 56/0015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220386898 | OSTADABBAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah OSTADABBAS (Watertown, Massachusetts); Shuangjun LIU (Boston, Massachusetts) |
| ABSTRACT | Provided herein are systems and methods for estimating contact pressure of a human lying on a surface including one or more imaging devices having imaging sensors oriented toward the surface, a processor and memory, including a trained model for estimating human contact pressure trained with a dataset including a plurality of human lying poses including images generated from at least one of a plurality of imaging modalities including at least one of a red-green-blue modality, a long wavelength infrared modality, a depth modality, or a pressure map modality, wherein the processor can receive one or more images from the imaging devices of the human lying on the surface and a source of one or more physical parameters of the human to determine a pressure map of the human based on the one or more images and the one or more physical parameters. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831993 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1116 (20130101) Original (OR) Class A61B 5/1128 (20130101) Image Data Processing or Generation, in General G06T 7/75 (20170101) G06T 7/90 (20170101) G06T 2207/10024 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/20081 (20130101) G06T 2207/30196 (20130101) Image or Video Recognition or Understanding G06V 40/10 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386908 | Emaminejad et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sam Emaminejad (Los Angeles, California); Shuyu Lin (Los Angeles, California); Bo Wang (Los Angeles, California) |
| ABSTRACT | Example implementations include a method of applying a voltage pulse having a magnitude within a biochemical voltage window associated a biochemical, obtaining a response current from a biochemical sensor electrode, generating a biochemical response voltammogram based on the response current, extracting a current peak from the biochemical response voltammogram, and generating a biochemical concentration based on the current peak. Example implementations further include a method of applying a differential pulse sequence including the voltage pulse to the reference electrode. Example implementations further include a method of applying the differential pulse sequence further comprises applying the differential pulse sequence to the reference electrode at an increasing voltage step. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771440 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1477 (20130101) A61B 5/1495 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220386957 | Ganesan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepak Ganesan (Amherst, Massachusetts); Trisha L. Andrew (Hadley, Massachusetts); Ali Kiaghadi (Amherst, Massachusetts); Seyedeh Zohreh Homayounfar (Amherst, Massachusetts); Jeremy Gummeson (Belchertown, Massachusetts) |
| ABSTRACT | A garment system comprises a garment substrate formed from one or more textile-based sheets, a distributed array of a plurality of resistive pressure sensors coupled to the garment substrate at a set of first specified locations. Each of the plurality of resistive sensors comprises a pair of first textile-based outer layers each having an electrical resistance of no more than 100 ohms and a textile-based inner layer sandwiched between the pair of first textile-based outer layers having an electrical resistance of at least 1 mega-ohm. The system also includes electronics configured to process signals from the distributed array of resistive pressure sensors to determine one or more physiological properties of a wearer of the garment substrate. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/818158 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/005 (20130101) A41D 31/04 (20190201) Diagnosis; Surgery; Identification A61B 5/1102 (20130101) A61B 5/1116 (20130101) A61B 5/6804 (20130101) Original (OR) Class A61B 5/6823 (20130101) A61B 2562/0247 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/08 (20130101) B32B 5/024 (20130101) B32B 5/26 (20130101) B32B 7/025 (20190101) B32B 2250/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2255/205 (20130101) B32B 2262/062 (20130101) B32B 2262/0261 (20130101) B32B 2307/73 (20130101) B32B 2307/202 (20130101) B32B 2307/204 (20130101) B32B 2307/206 (20130101) B32B 2437/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387610 | XU et al. |
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| FUNDED BY |
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| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing XU (Newton, Massachusetts); Jiaqing WANG (Waltham, Massachusetts) |
| ABSTRACT | The present disclosure relates to a conjugated prodrug comprising a peptide conjugated to an antibiotic molecules via a cleavable linker and pharmaceutical compositions thereof. Also disclosed are methods of enhancing the intracellular concentration of an antibiotic agent in a bacterium and methods of treating a patient for a bacterial infection. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/761496 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387940 | Adamson et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Adamson (Mansfield Center, Connecticut); Chinthani D. Liyanage (Willimantic, Connecticut) |
| ABSTRACT | A composite that includes graphene and an interfacially-polymerized polyamide, where the composite is in the form of a self-supporting membrane having a graphene side opposite to a polyamide side, or the composite is in the form of a microparticle comprising a graphene core and a polyamide shell, a method of manufacture of the composites by interfacial polymerization and methods of use of the composite are described. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834387 |
| CURRENT CPC | Separation B01D 71/021 (20130101) Original (OR) Class B01D 71/56 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) B01J 20/262 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) C02F 1/469 (20130101) C02F 1/4672 (20130101) C02F 2103/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220387991 — DEVICE AND METHOD FOR NONINVASIVELY AND ELECTROCHEMICALLY SENSING IN VIVO BIOCHEMICALS
| US 20220387991 | Emaminejad et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sam Emaminejad (Los Angeles, California); Yichao Zhao (Los Angeles, California); Bo Wang (Los Angeles, California) |
| ABSTRACT | Example implementations include a method of manufacturing a biochemical sensor by forming a fluid conduit in a microfluidic layer, forming an electrode on an electrode layer, forming a biochemical sensor on the electrode layer, bonding the electrode layer to a first surface of the microfluidic layer, and bonding a barrier layer to a second surface of the microfluidic layer. Example implementations also include a method of electrically detecting a biochemical by contacting an electrode array to a biological surface, obtaining a biofluid at the electrode array from the biological surface, obtaining a response current associated with the biofluid at the electrode array, and generating a quantitative biochemical response based at least partially on the response current. Example implementations further include applying a current to the biological surface. Example implementations further include filtering electrical interference at the electrode array. Example implementations further include generating a quantitative biochemical response based on the response current. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/763149 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1468 (20130101) A61B 5/14507 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Original (OR) Class B01L 2300/047 (20130101) B01L 2300/0645 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387995 | Kurabayashi et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katsuo Kurabayashi (Ann Arbor, Michigan); Kevin R. Ward (Superior Township, Michigan); Young Geun Park (Ann Arbor, Michigan); Xiaogan Liang (Ann Arbor, Michigan); Byunghoon Ryu (Ann Arbor, Michigan) |
| ABSTRACT | A blood biomarker analysis systems providing fast biomarker identification includes a multimodal bioassay device having a biosensor within a portable pipette-shaped device and using nanoplasmonic barcode detectors, such as formed of antibody conjugated gold nanoparticle arrays (AuNPs), capable of capturing any of a plurality of biomarkers. The biomarker analysis system further includes the pipette-shaped device being smartphone-connected and portable to form a highly accurate, point-of-care bioassay device. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771377 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/021 (20130101) B01L 2300/023 (20130101) B01L 2300/0636 (20130101) B01L 2300/0816 (20130101) B01L 2300/0896 (20130101) B01L 2400/0478 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 33/54366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388002 | GURKAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umut GURKAN (Cleveland, Ohio); Erdem KUCUKAL (Cleveland, Ohio); Yuncheng MAN (Cleveland, Ohio) |
| ABSTRACT | A microfluidic device includes at least one microchannel with a plurality of micropillar arrays provided along a length of the microchannel. Each micropillar array defines a plurality microcapillaries having cross sectional area, and the cross sectional area of the microcapillaries defined by each micropillar array decreases in a direction of fluid flow through the microchannel. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/776112 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150022 (20130101) A61B 5/150358 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Original (OR) Class B01L 2200/0668 (20130101) B01L 2300/0816 (20130101) B01L 2300/0877 (20130101) B01L 2400/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388026 | Park et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Jiwoong Park (Chicago, Illinois); Yu Zhong (Chicago, Illinois); Baorui Cheng (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are inventive methods of making thin films, inventive thin films, and inventive articles and systems comprising thin films. Certain embodiments are related to methods of making thin films in which reagents are arranged within a first phase and a second phase such that at least one reagent reacts to form a thin film proximate to the interface between the first phase and the second phase. Thin films (including two-dimensional materials) disclosed herein can have one or more of a variety of beneficial properties including large lateral dimension(s), lateral continuity, high mechanical strength, consistent spatial composition, and/or consistent thickness. In accordance with certain embodiments, thin films disclosed herein can be combined to form a variety of inventive multi-layer articles, including multi-layer articles comprising a combination of thin films having different compositions that interact with each other via van der Waals forces. |
| FILED | Tuesday, October 06, 2020 |
| APPL NO | 17/767125 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/20 (20130101) B05D 1/185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388898 | LUO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tengfei Luo (Granger, Indiana) |
| ASSIGNEE(S) | Tengfei Luo (Granger, Indiana) |
| INVENTOR(S) | Tengfei LUO (Granger, Indiana); Eungkyu LEE (Yongin-si, South Korea); Seunghyun MOON (Mishawaka, Indiana) |
| ABSTRACT | Systems and methods are disclosed for depositing particles on a substrate, the method comprising generating a thermal bubble on a surface of a substrate submerged in a medium having suspended particles such that the thermal bubble deposits the particles on the substrate; and deflating the thermal bubble such that the deposited particles are pulled toward a central position to form an island of particles. |
| FILED | Wednesday, June 01, 2022 |
| APPL NO | 17/829771 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/002 (20130101) Original (OR) Class C03C 23/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389084 | Brown et al. |
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| FUNDED BY |
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| APPLICANT(S) | Elektrofi, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Brown (Boston, Massachusetts); Tyler L. Carter (Newburyport, Massachusetts); Lyndon Fitzgerald Charles, JR. (Medford, Massachusetts); Chase Spenser Coffman (Newton, Massachusetts); Daniel Benjamin Dadon (East Boston, Massachusetts); Lisa Liu (Somerville, Massachusetts); Sadiqua Shadbar (Allston, Massachusetts); Chaitanya Sudrik (Stoneham, Massachusetts); Yi Tang (Medford, Massachusetts); Shankul Vartak (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/883427 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389185 | Qi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hang Qi (Atlanta, Georgia); Kai Yu (Atlanta, Georgia); Qian Shi (Atlanta, Georgia); Xiao Kuang (Atlanta, Georgia) |
| ABSTRACT | Various methods of reshaping and recycling thermoset polymers and composites containing thermoset polymers are provided. The methods involve the bond exchange reaction of exchangeable covalent bonds in the polymer matrix with a suitable small molecule solvent in the presence of a catalyst. In some aspects, the methods are applied to a carbon fiber reinforced polymer or a thermoset polymer where the thermoset polymer matrix includes a plurality of ester bonds. Using a small molecule alcohol, the methods provide for recycling one or both of the carbon fiber and the polymer, for welding two surfaces, or for repairing a damaged surface in the materials. |
| FILED | Friday, August 12, 2022 |
| APPL NO | 17/819335 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/16 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/195 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/04 (20130101) C08J 5/24 (20130101) C08J 5/121 (20130101) C08J 11/24 (20130101) Original (OR) Class C08J 2363/00 (20130101) C08J 2367/06 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/103 (20130101) C08K 7/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389209 | COATES et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Geoffrey COATES (Lansing, New York); James EAGAN (Austin, Texas); Anne LAPOINTE (Ithaca, New York); Frank S. BATES (St. Louis Park, Minnesota) |
| ABSTRACT | A semicrystalline multiblock copolymer includes alternating blocks of semicrystalline isotactic polypropylene (iPP) and semicrystalline polyethylene (PE), having a block arrangement according to formula (I): (iPPw)p(PEx)(iPPy)m(PEz)n (I), wherein p is 0 or 1; m is 0 or 1; n is 0 or 1; the sum of p, m, and n is 1, 2, or 3; and the sum of w, x, y, and z is greater than or equal to 40 kg/mol, with the provisos that: when m and n are 0, the sum of w and x is greater than or equal to 140 kg/mol; and when p and n are 0, the sum of y and x is greater than or equal to 140 kg/mol. Related compositions and methods are also provided. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650794 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) B32B 27/08 (20130101) B32B 27/32 (20130101) B32B 2250/02 (20130101) B32B 2250/242 (20130101) B32B 2323/04 (20130101) B32B 2323/10 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/76 (20130101) C08F 110/02 (20130101) C08F 110/06 (20130101) Compositions of Macromolecular Compounds C08L 53/00 (20130101) Original (OR) Class C08L 2203/16 (20130101) C08L 2207/10 (20130101) C08L 2207/062 (20130101) C08L 2207/066 (20130101) C08L 2207/068 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 153/00 (20130101) C09J 2423/046 (20130101) C09J 2423/106 (20130101) C09J 2453/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389310 | Huang et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Yunping Huang (Seattle, Washington); Christine Keiko Luscombe, III (Seattle, Washington) |
| ABSTRACT | The present disclosure features a luminescent molecule, including a luminophore (e.g., a fluorescent dye); and a moiety including a heteroaryl core covalently and directly bonded to the luminophore. The luminescent molecule has an increased photoluminescence quantum yield relative to an analogous luminophore without a covalently bonded moiety including the heteroaryl core. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/762599 |
| CURRENT CPC | Heterocyclic Compounds C07D 473/12 (20130101) C07D 519/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1007 (20130101) C09K 2211/1011 (20130101) C09K 2211/1014 (20130101) C09K 2211/1018 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0054 (20130101) H01L 51/0072 (20130101) H01L 51/5012 (20130101) H01L 2251/552 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389364 | SWOBODA et al. |
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| FUNDED BY |
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| APPLICANT(S) | NAVAN TECHNOLOGIES, INC. (Palo Alto, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | NAVAN TECHNOLOGIES, INC. (Palo Alto, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Ryan T. SWOBODA (Orange Park, Florida); Whitney BURKS (Stanford, California); Sergio LEAL-ORTIZ (Hayward, California); Amanda JONSSON (Stanford, California); Nicholas A. MELOSH (Menlo Park, California) |
| ABSTRACT | Described herein are nano straw well insert apparatuses (e.g., devices and systems) that include nanotubes extending through and out of a membrane so that a material can pass through the membrane from a fluid reservoir depot and into a cell grown onto the nanotubes when electrical energy (e.g., electroporation energy) is applied. In particular, the device, systems and methods described herein may be adapted for cell growth viability and transfection efficiency (e.g., >70%). These apparatuses may be readily integratable into cell culturing processes for improved transfection efficiency, intracellular transport, and cell viability. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/762152 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/04 (20130101) C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389416 | TOWNSLEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brad TOWNSLEY (Davis, California); Michael F. COVINGTON (Davis, California); Neelima SINHA (Davis, California) |
| ABSTRACT | Provided herein are compositions, kits and methods for the production of strand-specific cDNA libraries. The compositions, kits and methods utilize properties of double stranded polynucleotides, such as RNA-cDNA duplexes to capture and incorporate a novel sequencing adapter. The methods are useful transcriptome profiling by massive parallel sequence, such as full-length RNA sequencing (RNA-Seq) and 3′ tag digital gene expression (DGE). |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/667841 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1096 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 2521/107 (20130101) C12Q 2525/155 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2535/122 (20130101) C12Q 2537/137 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389498 | Green |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard E. Green (Santa Cruz, California) |
| ABSTRACT | Provided are methods of producing nucleic acid libraries. In certain aspects, the methods include combining target nucleic acids (e.g., 5′ phosphorylated nucleic acids) and an oligonucleotide pool. Oligonucleotides of the oligonucleotide pool may include complementarity regions of varying length and nucleotide sequence, and a complementarity region identification sequence. In such aspects, the combining is under conditions in which oligonucleotides of the oligonucleotide pool hybridize to nucleic acids of the target nucleic acids (e.g., 5′ phosphorylated nucleic acids) having overhang regions that are complementary in sequence and have corresponding lengths with respect to the complementarity regions of the oligonucleotides. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided. |
| FILED | Tuesday, March 01, 2022 |
| APPL NO | 17/684256 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 2521/501 (20130101) C12Q 2525/179 (20130101) C12Q 2525/191 (20130101) C12Q 2525/204 (20130101) C12Q 2533/107 (20130101) C12Q 2563/179 (20130101) C12Q 2565/631 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389600 | Mishra et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Rohan Mishra (St. Louis, Missouri); John Cavin (St. Louis, Missouri) |
| ABSTRACT | Two-dimensional (2D) high-entropy transition metal dichalcogenide (TMDC) alloy compositions, methods of synthesizing the TMDC alloys, physical/chemical properties of the TMDC alloys, and uses of the TMDC alloys as catalysts in electrochemical reactions are disclosed. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835617 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 1/50 (20210101) C25B 11/089 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390432 | Young et al. |
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| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Ann Boija (Somerville, Massachusetts); Isaac Klein (Milton, Massachusetts) |
| ABSTRACT | Described herein are methods of characterizing agent incorporation into condensates, methods of reducing transcription of oncogenes associated with condensates, and methods of using peptides to inhibit nuclear receptor and cofactor binding in condensates. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/611560 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390445 | Tabib-Azar |
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| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Massood Tabib-Azar (Salt Lake City, Utah) |
| ABSTRACT | A visibly perceived colorimetric pathogen sensor (100) can comprise a substrate (110) and an molecular recognition group (120) coupled to the substrate (110). The molecular recognition group (120) can be operable to bind to a target pathogen (130). Upon the molecular recognition group (120) binding with the target pathogen (130), reflected light can be altered thereby changing apparent color. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/771053 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54373 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390974 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peng Zhang (Jericho, New York); Lizhi Wang (Farmingville, New York); Zefan Tang (Stony Brook, New York) |
| ABSTRACT | A software-defined control (SDC)-enabled microgrid system includes a physical plane having multiple distributed energy resources (DERs), the DERs being operatively coupled together via a bus, and a control plane. The control plane includes at least one virtual controller running on a hardware server in the control plane, a system analysis module in communication with the physical plane, and an SDC manager coupled with the virtual controller and the system analysis module. The virtual controller includes multiple software-defined functional modules configured to control prescribed parameters of the microgrid. The system analysis module is configured to generate system analytics information as a function of operational information associated with one or more DERs in the physical plane. The SDC manager is configured to generate one or more virtual controllers for controlling an operation of at least a subset of the DERs in the physical plane as a function of the system analytics information. |
| FILED | Thursday, May 26, 2022 |
| APPL NO | 17/825416 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/06 (20130101) H02J 3/38 (20130101) H02J 13/00002 (20200101) H02J 13/00032 (20200101) H02J 2203/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391553 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Jiansong Zhang (Lafayette, Indiana); Temitope Akanbi (Windsor, Canada) |
| ABSTRACT | A method of generating a three-dimensional (3D) structure model from a two-dimensional (2D) drawing file, which includes one or more illustrations of a structure, using a data processing device includes importing the 2D drawing file to the data processing device, converting the 2D drawing file into a raster graphics file, converting the raster graphics file into a vector graphics file, extracting one or more graphical projections representative of the structure from the vector graphics file, converting the one or more projections into a tagged data graphics file, forming a 3D structure model representative of the structure by connecting the plurality of cartesian points of the tagged data graphics file, and generating an electronic output file including the 3D structure model. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/832771 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Original (OR) Class G06F 30/23 (20200101) Image Data Processing or Generation, in General G06T 17/205 (20130101) G06T 19/20 (20130101) G06T 2219/2004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220391743 | Wild et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominik S. Wild (Somerville, Massachusetts); Dries Sels (Allston, Massachusetts); Hannes Pichler (Concord, Massachusetts); Mikhail D. Lukin (Cambridge, Massachusetts) |
| ABSTRACT | A system includes a quantum computer, and a computing node configured to: receive a description of a probability distribution, determine a first Hamiltonian having a ground state encoding the probability distribution, determine a second Hamiltonian, the second Hamiltonian being continuously transformable into the first Hamiltonian via a path through at least one quantum phase transition, and provide instructions to the quantum computer to: initialize a quantum system according to a ground state of the second Hamiltonian, and evolve the quantum system from the ground state of the second Hamiltonian to the ground state of the first Hamiltonian according to the path through the at least one quantum phase transition. The computing node is further configured to receive from the quantum computer a measurement on the quantum system, thereby obtaining a sample from the probability distribution. |
| FILED | Wednesday, July 06, 2022 |
| APPL NO | 17/858570 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/60 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392343 | Park et al. |
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| FUNDED BY |
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| APPLICANT(S) | North Carolina Agricultural and Technical State University (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyoshin Park (Greensboro, North Carolina); Larkin Folsom (Mebane, North Carolina) |
| ABSTRACT | Methods and systems for dynamically providing routes to users of vehicles. In some examples, a method includes determining a first traffic flow model for uninformed drivers of vehicles and determining a second traffic flow model for informed drivers of vehicles. Each of the informed drivers makes driving decisions based on receiving dynamic routes from a traffic routing system. The method includes iteratively updating the second traffic flow model using the first traffic flow model until a convergence criterion is met. The method includes sending, to at least one informed driver, a first dynamic route from a first origin to a first destination using the second traffic flow model. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826723 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Traffic Control Systems G08G 1/0133 (20130101) G08G 1/0141 (20130101) G08G 1/0145 (20130101) G08G 1/096725 (20130101) G08G 1/096811 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392482 | Mesgarani et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nima Mesgarani (New York, New York); Yi Luo (New York, New York); James O'Sullivan (New York, New York); Zhuo Chen (New York, New York) |
| ABSTRACT | Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated). |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/826474 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/318 (20210101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/26 (20130101) G10L 25/30 (20130101) Original (OR) Class G10L 25/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392756 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833337 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) Original (OR) Class H01J 49/42 (20130101) H01J 49/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393091 | HOUCK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Priinceton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew HOUCK (Princeton, New Jersey); Nathalie DE LEON (Princeton, New Jersey); Robert Joseph CAVA (Princeton, New Jersey); Alex PLACE (Princeton, New Jersey); Lila RODGERS (Princeton, New Jersey); Sara SUSSMAN (Princeton, New Jersey); Mattias FITZPATRICK (Princeton, New Jersey); Basil SMITHAM (Princeton, New Jersey) |
| ABSTRACT | Methods, devices, and systems are described for forming a superconducting qubit. An example device may comprise a substrate having a first surface and a patterned layer adjacent the substrate and comprising tantalum in an alpha phase. The patterned layer may comprise at least a part of a structure for storing a quantum state. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/776078 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/12 (20130101) H01L 39/2493 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393363 | Jornet et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Government of the United Stated as represented by the Secretary of the Air Force (Rome, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josep Miquel Jornet (Needham, Massachusetts); Arjun Singh (Southbridge, Massachusetts); Michael Andrello (Rome, New York); Erik Einarsson (Buffalo, New York); Ngwe Thawdar (Rome, New York) |
| ABSTRACT | A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/804446 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 15/148 (20130101) Original (OR) Class H01Q 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393364 | KAMALI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyedeh Mahsa KAMALI (ARCADIA, California); Ehsan ARBABI (ARCADIA, California); Andrei FARAON (LA CANADA FLINTRIDGE, California) |
| ABSTRACT | Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843302 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/3083 (20130101) G02B 27/44 (20130101) G02B 27/0944 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70408 (20130101) Antennas, i.e Radio Aerials H01Q 1/422 (20130101) H01Q 1/425 (20130101) H01Q 15/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220387926 | LU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Yongqi LU (Urbana, Illinois); Yang DU (Champaign, Illinois); Qing YE (Urbana, Illinois) |
| ABSTRACT | An aqueous solvent composition is provided, comprising a nucleophilic component having one or more sterically unhindered primary or secondary amine moieties, a Brønsted base component having one or more basic nitrogen moieties, a water-soluble organic solvent, and water. A biphasic composition is provided, comprising one or more carbamate compounds, one or more conjugate acids of Brønsted base, a water-soluble organic solvent, and water. A biphasic CO2 absorption process is also provided, utilizing the biphasic solvent composition. |
| FILED | Wednesday, July 27, 2022 |
| APPL NO | 17/815394 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/78 (20130101) B01D 53/96 (20130101) B01D 53/1425 (20130101) B01D 53/1475 (20130101) B01D 53/1493 (20130101) Original (OR) Class B01D 2252/504 (20130101) B01D 2252/2041 (20130101) B01D 2252/20405 (20130101) B01D 2252/20415 (20130101) B01D 2252/20421 (20130101) B01D 2252/20426 (20130101) B01D 2252/20431 (20130101) B01D 2252/20442 (20130101) B01D 2252/20447 (20130101) B01D 2252/20473 (20130101) B01D 2252/20484 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) Acyclic or Carbocyclic Compounds C07C 211/03 (20130101) C07C 211/06 (20130101) C07C 211/11 (20130101) C07C 211/13 (20130101) C07C 211/17 (20130101) Heterocyclic Compounds C07D 213/16 (20130101) C07D 221/00 (20130101) C07D 223/04 (20130101) C07D 235/00 (20130101) C07D 241/04 (20130101) C07D 265/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388856 | Grady et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zane Michael Grady (University Park, Pennsylvania); Arnaud Ndayishimiye (University Park, Pennsylvania); Clive A. Randall (University Park, Pennsylvania) |
| ABSTRACT | Embodiments relate to a method for fabricating a sintered sodium-ion material. The method involves mixing a parent phase sodium-ion compound with a secondary transient phase to form a powder mixture. The method involves applying pressure and heat above a melting point or boiling point of the secondary transient phase to drive dissolution at particle contacts and subsequent precipitation at newly formed grain boundaries. The method involves generating a sintered sodium-ion material with >90% relative density. |
| FILED | Friday, March 25, 2022 |
| APPL NO | 17/656587 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 7/028 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/10 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0407 (20130101) H01M 10/0562 (20130101) H01M 2300/0071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389302 | Welch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chevron U.S.A. Inc. (San Ramon, California); Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan James Welch (White Rock, New Mexico); Hakim Boukhalfa (Santa Fe, New Mexico); Robert David Gilbertson (Los Alamos, New Mexico); Rajesh S. Nair (Houston, Texas); Deryck Edward Matthew Williams (Houston, Texas); Timothy Leo Quirk (Fulshear, Texas) |
| ABSTRACT | Embodiments of the disclosure include swellable smart gel sealants and methods of using smart gel sealants. In certain embodiments, the smart gel sealants reversibly swell when exposed to a certain trigger, such as carbonic acid and/or sulfuric acid. In specific embodiments, the smart gel is comprised within a cement composition. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/816760 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 24/2688 (20130101) C04B 28/02 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/487 (20130101) Original (OR) Class Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 33/14 (20130101) E21B 47/005 (20200501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390326 | Wissink et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin L. Wissink (Oak Ridge, Tennessee); Christopher L. Wray (Oak Ridge, Tennessee); Scott J. Curran (Oak Ridge, Tennessee); Ke An (Oak Ridge, Tennessee); Matthew J. Frost (Oak Ridge, Tennessee); Yan Chen (Oak Ridge, Tennessee) |
| ABSTRACT | An internal combustion engine for neutron diffraction analysis is provided. The engine includes an elongated piston chamber formed from an aluminum alloy to ensure maximum neutron visibility into the combustion chamber. An elongated piston assembly reciprocates within the elongated piston chamber, the piston assembly including an upper piston joined to a lower piston. The upper piston and the lower piston are hollow, thereby reducing the reciprocating mass and increasing neutron access to the combustion chamber. The upper piston is lubricated with a neutron-transparent fluorocarbon lubricant such as perfluoropolyether (PFPE), while the lower piston and the crankcase are lubricated with hydrocarbon lubricant. The engine enables 3D and time-resolved measurements of strain, stress, and temperature, as well as phase transformation, texture, and microstructure. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/833989 |
| CURRENT CPC | Cooling of Machines or Engines in General; Cooling of Internal-combustion Engines F01P 3/02 (20130101) F01P 3/08 (20130101) F01P 2003/021 (20130101) Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 1/36 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 15/02 (20130101) G01M 15/042 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390669 | BOWERS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. BOWERS (Santa Barbara, California); Arthur GOSSARD (Santa Barbara, California); Daehwan JUNG (Goleta, California); Justin NORMAN (Goleta, California); Chen SHANG (Goleta, California); Yating WAN (Goleta, California) |
| ABSTRACT | A photonic integrated circuit (PIC) includes a semiconductor substrate, one or more passive components, and one or more active components. The one or more passive components are fabricated on the semiconductor substrate, wherein the passive components are fabricated in a III-V type semiconductor layer. The one or more active components are fabricated on top of the one or more passive components, wherein optical signals are communicated between the one or more active components via the one or more passive components. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/882909 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 6/13 (20130101) G02B 6/1225 (20130101) G02B 6/12004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392078 | Bolintineanu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Stefan Bolintineanu (Albuquerque, New Mexico); Enrico C. Quintana (Albuquerque, New Mexico); Sharlotte Lorraine Bolyard Kramer (Albuquerque, New Mexico); Robert Waymel (Albuquerque, New Mexico); Kevin Nicholas Long (Cedar Crest, New Mexico) |
| ABSTRACT | Illustrative embodiments are directed to methods, apparatus and computer program products for segmentation of X-ray tomography images via multiple reconstructions. A computed tomography scan of an object is received. The computed tomography scan is processed to generate an absorption reconstruction and a phase reconstruction from the computed tomography scan. First and second sets of seeds within the phase reconstruction are labeled as corresponding to a first phase by thresholding below a first threshold and corresponding to a second phase by thresholding above a second threshold, respectively. The absorption reconstruction is segmented automatically using an algorithm based on the first set of seeds, the second set of seeds and the absorption reconstruction. A final segmentation is produced based on a combination of the absorption reconstruction and the phase reconstruction. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/338867 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/136 (20170101) G06T 7/143 (20170101) Original (OR) Class G06T 11/006 (20130101) G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392651 | Meier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric T. Meier (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Uri Shumlak (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827396 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) Original (OR) Class G21B 1/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392657 | Arafat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); Qnergy Inc. (Ogden, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yasir Arafat (Idaho Falls, Idaho); Carl E. Baily (Idaho Falls, Idaho); Douglas C. Crawford (Idaho Falls, Idaho); Blair K. Grover (Idaho Falls, Idaho); Carlo Parisi (Idaho Falls, Idaho); Allen Peterson (Eden, Utah) |
| ABSTRACT | An energy production device may include a core configured to heat a heat transmission fluid, an energy harnessing device configured to convert heat into electrical energy and a heat transfer device positioned over the core configured to receive the heat transmission fluid and transfer the heat to the energy harnessing device. The energy production device may further include a vibration isolator positioned between the energy harnessing device and the heat transfer device. The vibration isolator may be configured to secure the energy harnessing device to the heat transfer device and substantially prevent the transmission of motion from the energy harnessing device to the heat transfer device. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/805250 |
| CURRENT CPC | Nuclear Reactors G21C 15/02 (20130101) G21C 15/28 (20130101) Nuclear Power Plant G21D 1/02 (20130101) Original (OR) Class G21D 5/08 (20130101) G21D 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392669 | Majkic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Goran Majkic (Houston, Texas); Venkat Selvamanickam (Houston, Texas) |
| ABSTRACT | An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/887844 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/0209 (20130101) C23C 16/408 (20130101) C23C 16/448 (20130101) C23C 16/545 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/06 (20130101) Original (OR) Class H01B 13/00 (20130101) H01B 13/008 (20130101) H01B 13/0026 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/2441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392882 | Wilkerson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett P. Wilkerson (Austin, Texas); Milind S. Bhagavat (Cupertino, California); Rahul Agarwal (San Francisco, California); Dmitri Yudanov (Austin, Texas) |
| ABSTRACT | A three-dimensional integrated circuit includes a first die structure having a first geometry. The first die structure includes a first region that operates with a first power density and a second region that operates with a second power density. The first power density is less than the second power density. The three-dimensional integrated circuit includes a second die structure having a second geometry. A stacked portion of the second die structure is aligned with the first region. The three-dimensional integrated circuit includes an additional die structure stacked with the first die structure and the second die structure. The additional die structure has the first geometry or the second geometry. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/891444 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/481 (20130101) H01L 23/3675 (20130101) H01L 24/03 (20130101) H01L 24/05 (20130101) H01L 24/06 (20130101) H01L 24/08 (20130101) H01L 24/09 (20130101) H01L 25/18 (20130101) Original (OR) Class H01L 25/50 (20130101) H01L 2224/0557 (20130101) H01L 2224/03002 (20130101) H01L 2224/06179 (20130101) H01L 2224/06181 (20130101) H01L 2224/08146 (20130101) H01L 2224/09179 (20130101) H01L 2924/1431 (20130101) H01L 2924/1433 (20130101) H01L 2924/1434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393182 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (, None) |
| INVENTOR(S) | Weiyang Li (Sunnyvale, California); Yi Cui (Stanford, California); Zhi Wei Seh (Stanford, California); Guangyuan Zheng (Stanford, California); Yuan Yang (Stanford, California) |
| ABSTRACT | A method of forming a sulfur-based cathode material includes: 1) providing a sulfur-based nanostructure; 2) coating the nanostructure with an encapsulating material to form a shell surrounding the nanostructure; and 3) removing a portion of the nanostructure through the shell to form a void within the shell, with a remaining portion of the nanostructure disposed within the shell. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538677 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/30 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/76 (20130101) Original (OR) Class H01M 4/136 (20130101) H01M 4/621 (20130101) H01M 4/622 (20130101) H01M 4/1397 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393203 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sichao Ma (Dublin, California); Sara Hunegnaw (Oakland, California); Ziyang Huo (Moraga, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California); Alvin Leung (San Francisco, California); Timothy A. Bekkedahl (Fremont, California) |
| ABSTRACT | Provided herein are methods for operating carbon oxide (COX) reduction reactors (CRR) and related apparatus. In some embodiments, the methods involve shutting off, reducing, or otherwise controlling current during various operation stages including hydration, break-in, normal operation, planned shut-offs, and extended shutoff or storage periods. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/662225 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/23 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04574 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393230 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (, None) |
| INVENTOR(S) | Guosheng Li (Richland, Washington); Vincent L. Sprenkle (Richland, Washington); Minyuan M. Li (Richland, Washington); David M. Reed (Richland, Washington); Evgueni Polikarpov (Richland, Washington) |
| ABSTRACT | Rechargeable batteries include a NiyFe1-y cathode where 0≤y≤1, an anode comprising a current collector, a porous separator positioned between the cathode and the anode, and an electrolyte comprising MAlX4, wherein M is Na, Li, K, or a combination thereof, and X is Cl, Br, I, or a combination thereof, and wherein the electrolyte is a solid at temperatures less than 50° C. The batteries are temperature activated. The electrolyte temperature is increased above its melting point while charging and reduced below the melting point for energy storage, such as seasonal energy storage. The electrolyte temperature is increased above the melting point again to discharge the battery. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/330305 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 10/443 (20130101) H01M 10/0561 (20130101) Original (OR) Class H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393364 | KAMALI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seyedeh Mahsa KAMALI (ARCADIA, California); Ehsan ARBABI (ARCADIA, California); Andrei FARAON (LA CANADA FLINTRIDGE, California) |
| ABSTRACT | Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations. |
| FILED | Friday, June 17, 2022 |
| APPL NO | 17/843302 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/3083 (20130101) G02B 27/44 (20130101) G02B 27/0944 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/70408 (20130101) Antennas, i.e Radio Aerials H01Q 1/422 (20130101) H01Q 1/425 (20130101) H01Q 15/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393510 | Zhang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Zhang (Salt Lake City, Utah) |
| ABSTRACT | Active electromagnetic shielding for dynamic high power wireless charging and related electrified roadway systems, method, and wireless power transmitters is disclosed. A wireless power transmitter includes a first canceling coil offset from a power transmission coil, a second canceling coil offset from the power transmission coil, and circuitry electrically connected to the first canceling coil and the second canceling coil. The circuitry is configured to deliver canceling currents to the first canceling coil and the second canceling coil to destructively interfere with portions of electromagnetic fields generated by the power transmission coil. |
| FILED | Thursday, September 10, 2020 |
| APPL NO | 17/753533 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/12 (20190201) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/05 (20160201) H02J 50/12 (20160201) Original (OR) Class H02J 50/40 (20160201) H02J 50/70 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394362 | Michelogiannakis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios Michelogiannakis (Berkeley, California); Yiwen Shen (New York, New York); Min Yee Teh (New York, New York); John Shalf (Oakland, California); Madeleine Glick (New York, New York); Keren Bergman (New York, New York) |
| ABSTRACT | Disclosed herein are methods, systems, and devices for bandwidth steering. Systems may include a plurality of compute nodes configured to execute one or more applications, a plurality of first level resources communicatively coupled to the plurality of compute nodes, a plurality of second level resources communicatively coupled to the plurality of first level resources, and a plurality of third level resources communicatively coupled to the plurality of second level resources. Systems may also include a plurality of optical switch circuits communicatively coupled to the plurality of first level resources and the plurality of second level resources, wherein each of the plurality of optical switch circuits is coupled to more than one of the plurality of the first level resources and is also coupled to more than one of the plurality of the second level resources. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/775820 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Selecting H04Q 11/0005 (20130101) H04Q 11/0062 (20130101) Original (OR) Class H04Q 2011/0052 (20130101) H04Q 2011/0073 (20130101) H04Q 2011/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394838 | Shumlak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Eric T. Meier (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Friday, May 27, 2022 |
| APPL NO | 17/827379 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394839 | Shumlak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri Shumlak (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Eric T. Meier (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841591 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class H05H 1/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394840 | Meier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZAP ENERGY, INC. (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric T. Meier (Seattle, Washington); Brian A. Nelson (Edmonds, Washington); Uri Shumlak (Seattle, Washington) |
| ABSTRACT | Methods and systems are provided for plasma confinement utilizing various electrode and valve configurations. In one example, a device includes a first electrode positioned to define an outer boundary of an acceleration volume, a second electrode arranged coaxially with respect to the first electrode and positioned to define an inner boundary of the acceleration volume, at least one power supply to drive an electric current along a Z-pinch plasma column between the first second electrodes, and a set of valves to provide gas to the acceleration volume to fuel the Z-pinch plasma column, wherein an electron flow of the electric current is in a first direction from the second electrode to the first electrode. In additional or alternative examples, a shaping part is conductively connected to the second electrode to, in a presence of the gas, cause a gas breakdown of the gas to generate a sheared flow velocity profile. |
| FILED | Wednesday, June 15, 2022 |
| APPL NO | 17/841593 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220389415 | SALIT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Standford, California); THE GOVERNMENT OF THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF COMMERCE (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc SALIT (Gaithersburg, Maryland); Lars M. STEINMETZ (Stanford, California); Robert St. ONGE (Stanford, California); Justin D. SMITH (Stanford, California); Kevin ROY (Gaithersburg, Maryland) |
| ABSTRACT | Described herein are methods for making genetically modified cells by introducing combinations of genetic variants (designed or random) or constructs (genes or otherwise arbitrary DNA) into a population of cells, and for tracking each variant combination by sequentially building an array of barcodes at a common locus (chromosomal or plasmid), termed the barcode locus. Also described are the cells made by such methods. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/429250 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/1065 (20130101) C12N 15/1093 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390276 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Andrew Williams (Erie, Colorado); Daniel Rahn (El Segundo, California); Anna Katariina Vaskuri (Boulder, Colorado) |
| ABSTRACT | A gravity-enforced photon momentum radiometer incudes: a magnetic array; a diamagnetic shuttle that levitates above the magnetic array; a mirror on the diamagnetic shuttle that receives laser light and moves the diamagnetic shuttle due to the optical force; a tiltable platform for the magnetic array; a photogate producing gate light that can be blocked by a photo interrupter and that produces a detector signal that provides a position of the diamagnetic shuttle relative to the tiltable platform for determining a position of the diamagnetic shuttle relative to the photogate. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/831736 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 21/08 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/0403 (20130101) G01J 1/0414 (20130101) G01J 1/4257 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390496 | Aksyuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Anatolyevich Aksyuk (Gaithersburg, Maryland); Christopher Lee Holloway (Boulder, Colorado); Matthew Thomas Simons (Lafayette, Colorado); Alexandra Brea Artusio-Glimpse (Boulder, Colorado) |
| ABSTRACT | A photonic Rydberg atom radio frequency receiver includes: an integrated photonic chip; an atomic vapor cell; and a receiver member including: a photonic emitter; probe light reflectors disposed on the atomic vapor cell; and coupling light reflectors disposed on the atomic vapor cell such that the pair of coupling light reflectors is optically opposed across the interior vapor space and receives and reflects the coupling laser light so that the coupling laser light is reflected between the coupling light reflectors multiple times in the interior vapor space of the atomic vapor cell. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879704 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/0885 (20130101) Original (OR) Class G01R 29/0892 (20130101) G01R 33/02 (20130101) Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390760 | MCGEHEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. MCGEHEE (Boulder, Colorado); Jabez MCCLELLAND (Bethesda, Maryland); Vladimir AKSYUK (Gaithersburg, Maryland); Wenqi ZHU (Vienna, Virginia); Amit Kumar AGRAWAL (Rockville, Maryland) |
| ABSTRACT | An apparatus for light delivery to magneto-optical trap (MOT) system utilizes only planar optical diffraction devices including a planar-integrated-circuit PIC and a metasurface MS. When MOT is based on the use of a diffraction grating, a grating chip is additionally employed to launch and manipulate light for laser cooling. Bridging the gap between the sub-micrometer-scale guided mode on the PIC and the centimeter-scale beam needed for laser cooling, a magnification of the mode area by about 1010 is demonstrated using an on-chip extreme-mode-converter to launch a Gaussian mode into free space from a PIC-waveguide and a beam-shaping, polarization-dependent MS to form a diverging laser beam with a flat-top spatial profile, which efficiently illuminates the grating chip without loss of light. Comparison to equivalent Gaussian-beam-illuminated GMOTs evidences advantageous power efficiency of operation of the proposed light delivery system as compared with conventional systems employing Gaussian distribution of illumination at the grating chip. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831003 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1833 (20130101) G02B 27/4233 (20130101) G02B 27/4272 (20130101) Original (OR) Class Time-interval Measuring G04F 5/145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392188 | Klein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Areté Associates (Northridge, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy M. Klein (Huntsville, Alabama); Peter J. Rusello (Arlington, Virginia); Benjamin E.K. Sugerman (Baltimore, Maryland); Amanda M. Steck (Huntsville, Alabama) |
| ABSTRACT | Systems and methods herein provide for improving visibility in a scene. In one embodiment, a system includes a first camera device operable to capture images of a scene at a first band of wavelengths, and a second camera device operable to capture images of the scene at a second band of wavelengths. The first and second bands are different. The system also includes a processor communicatively coupled to the first and second camera devices, the processor being operable to detect an object in the scene based on a first of the images from the first camera device and based on a first of the images from the second camera device that was captured at substantially a same time as the first image from the first camera device, to estimate an obscurant in the scene based on the first images, and to estimate a visibility parameter of the scene based on the object and the estimated obscurant. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728906 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/009 (20130101) G06T 5/50 (20130101) G06T 2207/10048 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) Original (OR) Class G06V 10/82 (20220101) G06V 10/806 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220394404 | Allen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Albert Allen (Clarksburg, Maryland); Randall Paul Wagner (North Arlington, Virginia); Qian Dong (Philadelphia, Pennsylvania) |
| ABSTRACT | An interferometric microphone calibrator for comparison calibrating a microphone, the interferometric microphone calibrator comprising: an interferometer in optical communication with a microphone and that produces an interferometer measurement light, communicates the interferometer measurement light to the microphone, and receives an interferometer backscattered light from the microphone, such that a sensitivity of a test microphone is interferometrically calibrated to a reference microphone from the interferometer backscattered light; a preamplifier-controller in electrical communication with the microphone, and that receives a driver signal from a microphone driver and drives the microphone driver; the microphone driver in electrical communication with the preamplifier-controller and that receives a driver control signal from a calibration controller and produces the driver signal based on the driver control signal; and a calibration controller in electrical communication with the microphone driver and that produces the driver control signal and communicates the driver control signal to the microphone driver. |
| FILED | Wednesday, June 08, 2022 |
| APPL NO | 17/835478 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 29/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220387233 | Morin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven M. Morin (Minneapolis, Minnesota) |
| ABSTRACT | A drive assembly can comprise a plurality of drive arms that are configured to receive a tangential drive force and convert the tangential drive force to a torque about a first axis. A driven rotatable element can be rotatable about a second axis that is parallel to the first axis. A coupling subassembly can couple the plurality of drive arms to the driven rotatable element so that the first axis is movable with respect to the second axis in first and second dimensions that are perpendicular to each other and the first and second axes. The coupling subassembly can be configured to bias the driven rotatable element toward a position in which the first axis is collinear with the second axis. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/770235 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/023 (20130101) Original (OR) Class A61G 5/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220387650 | Jinadatha |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chetan Jinadatha (Temple, Texas) |
| ABSTRACT | The invention provides method for organizing the disinfection of one or more items contaminated with biological agent(s) comprising (a) attaching a radio-frequency ID (RFID) tag to an item(s) to be disinfected; exposing the item(s) of (a) to a disinfecting means for a period sufficient to disinfect the item; and (c) obtaining a signal from the tagged item when disinfection is complete thereby organizing the disinfection of one or more items. |
| FILED | Friday, August 19, 2022 |
| APPL NO | 17/892018 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/24 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/10118 (20130101) G06K 7/10415 (20130101) G06K 7/10475 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/22 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389510 | Zevallos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Jose Zevallos (St. Louis, Missouri); Aadel Chaudhuri (St. Louis, Missouri) |
| ABSTRACT | A method for detecting at least one surgery-related condition within a surgical site of a subject following a surgery is disclosed. The method includes providing at least one modular nucleic acid assay, obtaining a surgical drainage sample from the surgical site of the subject, isolating a nucleic acid-containing portion from the sample, and detecting and quantifying at least a portion of the amount of nucleic acids within the nucleic acid-containing portion using the at least one nucleic acid assay to produce at least one assay result. At least one assay result may be provided to a practitioner and used to select at least one additional treatment. The modular nucleic acid assays may be used in any combination with a single surgical drainage sample to assess minimal residual cancer, local immune environment, infection, transplant organ rejection, and/or free flap failure. |
| FILED | Thursday, June 02, 2022 |
| APPL NO | 17/831103 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389520 | Zevallos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Jose Zevallos (St. Louis, Missouri); Aadel Chaudhuri (St. Louis, Missouri) |
| ABSTRACT | A method for detecting at least one systemic condition and at least one locoproximal condition within a surgical site of a subject following a surgery is disclosed. The method includes obtaining a surgical drainage fluid sample from the surgical site and a blood sample from the subject, isolating analyte-containing portions from the surgical drainage fluid sample and the blood sample, and detecting and quantifying at least a portion of the analytes within the analyte-containing portions to produce at least one assay result, wherein the at least one assay result is indicative of the at least one systemic condition and the at least one locoproximal condition within a surgical site of a subject. At least one assay result may be provided to a practitioner and used to select at least one additional treatment. |
| FILED | Tuesday, June 07, 2022 |
| APPL NO | 17/834663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220392215 | XIAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiangming XIAO (Norman, Oklahoma); Jie WANG (Norman, Oklahoma) |
| ABSTRACT | A computer system having a processor executing a set of instructions that cause the processor to receive first image data having pixel information of a geographic region; calculate for particular real-world locations within the geographic region, a plurality of vegetation indices with combinations of the pixel information; generate a land cover mask with the vegetation indices, the land cover mask identifying first real-world locations within the geographic region having a water-related land cover type, a non-vegetated land cover type and an evergreen land cover type; classify second real-world locations within the geographic region that are not classified as the water-related land cover type, the non-vegetated land cover type and the evergreen land cover type as cropland; and analyze a time-series of image data depicting the second real-world locations within the geographic region with phenology metrics to identify at least one particular type of cropland within the second real-world locations. |
| FILED | Tuesday, May 31, 2022 |
| APPL NO | 17/828539 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/10024 (20130101) G06T 2207/10048 (20130101) G06T 2207/20081 (20130101) G06T 2207/30188 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) G06V 10/56 (20220101) G06V 10/764 (20220101) G06V 20/188 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392756 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Dalton Snyder (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833337 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) Original (OR) Class H01J 49/42 (20130101) H01J 49/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220393203 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Twelve Benefit Corporation (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sichao Ma (Dublin, California); Sara Hunegnaw (Oakland, California); Ziyang Huo (Moraga, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California); Alvin Leung (San Francisco, California); Timothy A. Bekkedahl (Fremont, California) |
| ABSTRACT | Provided herein are methods for operating carbon oxide (COX) reduction reactors (CRR) and related apparatus. In some embodiments, the methods involve shutting off, reducing, or otherwise controlling current during various operation stages including hydration, break-in, normal operation, planned shut-offs, and extended shutoff or storage periods. |
| FILED | Thursday, May 05, 2022 |
| APPL NO | 17/662225 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/23 (20210101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04574 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220389311 | Boatright |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Boatright (Lexington, Kentucky) |
| ABSTRACT | This disclosure relates to inorganic structured metal luminophores for the detection of peroxides and/or free radicals in proximity thereto. The disclosure includes the application of inorganic phosphates or mixtures thereof with one or more metal components that provides a structured metal luminophore capable of providing real-time detection and/or measurement of the presence of peroxides and/or free radicals in an environment proximal to the structured metal luminophore. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833490 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/0855 (20130101) C09K 11/0861 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389364 | SWOBODA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NAVAN TECHNOLOGIES, INC. (Palo Alto, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | NAVAN TECHNOLOGIES, INC. (Palo Alto, California); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Ryan T. SWOBODA (Orange Park, Florida); Whitney BURKS (Stanford, California); Sergio LEAL-ORTIZ (Hayward, California); Amanda JONSSON (Stanford, California); Nicholas A. MELOSH (Menlo Park, California) |
| ABSTRACT | Described herein are nano straw well insert apparatuses (e.g., devices and systems) that include nanotubes extending through and out of a membrane so that a material can pass through the membrane from a fluid reservoir depot and into a cell grown onto the nanotubes when electrical energy (e.g., electroporation energy) is applied. In particular, the device, systems and methods described herein may be adapted for cell growth viability and transfection efficiency (e.g., >70%). These apparatuses may be readily integratable into cell culturing processes for improved transfection efficiency, intracellular transport, and cell viability. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/762152 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/04 (20130101) C12M 35/02 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220392188 | Klein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Areté Associates (Northridge, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy M. Klein (Huntsville, Alabama); Peter J. Rusello (Arlington, Virginia); Benjamin E.K. Sugerman (Baltimore, Maryland); Amanda M. Steck (Huntsville, Alabama) |
| ABSTRACT | Systems and methods herein provide for improving visibility in a scene. In one embodiment, a system includes a first camera device operable to capture images of a scene at a first band of wavelengths, and a second camera device operable to capture images of the scene at a second band of wavelengths. The first and second bands are different. The system also includes a processor communicatively coupled to the first and second camera devices, the processor being operable to detect an object in the scene based on a first of the images from the first camera device and based on a first of the images from the second camera device that was captured at substantially a same time as the first image from the first camera device, to estimate an obscurant in the scene based on the first images, and to estimate a visibility parameter of the scene based on the object and the estimated obscurant. |
| FILED | Monday, April 25, 2022 |
| APPL NO | 17/728906 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/009 (20130101) G06T 5/50 (20130101) G06T 2207/10048 (20130101) Image or Video Recognition or Understanding G06V 10/26 (20220101) Original (OR) Class G06V 10/82 (20220101) G06V 10/806 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220389172 | Pan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuejun Pan (Madison, Wisconsin); Meijun Zeng (Madison, Wisconsin); Ning Li (Madison, Wisconsin) |
| ABSTRACT | Provided herein are methods for preparing a product including predominantly prebiotic oligosaccharides by non-enzymatic methods of glycosylation of monosaccharides, disaccharides, and/or polysaccharides. The methods may include mixing one or more types of monosaccharides, disaccharides, and/or polysaccharides with an effective amount of a dehydrating acid at a temperature sufficient to form a product including predominantly prebiotic oligosaccharides. |
| FILED | Friday, June 03, 2022 |
| APPL NO | 17/832490 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/08 (20130101) C07H 3/06 (20130101) Derivatives of Natural Macromolecular Compounds C08H 8/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220389311 | Boatright |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Boatright (Lexington, Kentucky) |
| ABSTRACT | This disclosure relates to inorganic structured metal luminophores for the detection of peroxides and/or free radicals in proximity thereto. The disclosure includes the application of inorganic phosphates or mixtures thereof with one or more metal components that provides a structured metal luminophore capable of providing real-time detection and/or measurement of the presence of peroxides and/or free radicals in an environment proximal to the structured metal luminophore. |
| FILED | Monday, June 06, 2022 |
| APPL NO | 17/833490 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/0855 (20130101) C09K 11/0861 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220388683 | Washington, II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William J. Washington, II (North Potomac, Maryland); Christian Jordan (Baltimore, Maryland) |
| ABSTRACT | A bag unlocking method includes receiving, by a bag handling system, a bag during a check-in process. The bag handling system identifies, from a travel carrier system, traveler information corresponding to the bag. A securing device of the bag is programmed, using an unlock code pertaining to the traveler information. The bag handling system reads a bag tag of the bag at a baggage inspection station and determines the unlock code pertaining to the bag tag. The bag handling system transmits the unlock code to cause the securing device to unlock at the baggage inspection station. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879427 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/366 (20130101) Original (OR) Class B64F 1/368 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220388906 | Yablonski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michelle Marie Yablonski (Hopkinton, Massachusetts); Arijit Bose (Lexington, Massachusetts) |
| ABSTRACT | A cement mixture is disclosed that includes an aqueous mending agent that is disbursed within but isolated from the cement mixture, wherein the aqueous mending agent will form molecular bonds with hardened cement that is formed by the cement mixture when the aqueous mending agent is permitted to flow within the hardened cement. |
| FILED | Thursday, August 11, 2022 |
| APPL NO | 17/885830 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 12/04 (20130101) C04B 20/1029 (20130101) C04B 22/085 (20130101) C04B 28/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20220389487 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ANDE Corporation (Waltham, Massachusetts) |
| ASSIGNEE(S) | ANDE Corporation (Waltham, Massachusetts) |
| INVENTOR(S) | Eugene Tan (Arlington, Massachusetts); Richard F. Selden (Lincoln, Massachusetts); Rosemary S. Turingan (Stoneham, Massachusetts) |
| ABSTRACT | Described herein are instruments for excitation and detection of fluorophores in a plurality of functional regions in a biochip, using an excitation source and a steering element that directs a beam from the excitation source to a plurality of functional regions in the biochip, wherein the excitation source excites the fluorophores in the plurality of functional regions generating a signal that is detected such that said signal from at least one of the plurality of functional regions allows for nucleic acid quantification. Also described are systems for quantification and separation and detection using optical devices adapted for preliminary, simultaneous or sequential quantitation of nucleic acid in separate detection positions, and for the excitation and detection of multiple samples to steer both the excitation and detection beam paths to separately image each lane of a biochip. |
| FILED | Monday, August 08, 2022 |
| APPL NO | 17/818194 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) B01L 7/52 (20130101) B01L 2300/168 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6818 (20130101) C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 27/10 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220389882 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendy Wenling Lin (Montgomery, Ohio); David Herman (Beavercreek, Ohio); Trevor Howard Wood (Clifton Park, New York); Nikolai N. Pastouchenko (Latham, New York); Kishore Ramakrishnan (Rexford, New York); Timothy Richard DePuy (Liberty Township, Ohio); Robert William Davidoff (Carnegie, Pennsylvania) |
| ABSTRACT | An acoustic core may include an array of resonant cells configured as a plurality of resonant cell groups. The resonant cell groups may include a plurality of resonant cells configured as a partitioned resonant cell that include a converging resonant cell and a diverging resonant cell. The converging resonant cell and the diverging resonant cell may be defined by a plurality of cell walls integrally formed with one another and a partition integrally formed with the plurality of cell walls. The partition may at least partially delimit the converging resonant cell from the diverging resonant cell. The converging resonant cell may define an upper resonant space delimited by the partition and a top face of the array of resonant cells. The diverging resonant cell may define a lower resonant space delimited by the partition and a bottom face of the array of resonant cells. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/338073 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Jet-propulsion Plants F02K 1/827 (20130101) Original (OR) Class Wind Motors F03D 80/00 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2260/96 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/963 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/161 (20130101) G10K 11/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
European Union (EU)
| US 20220390428 | Vahcic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE EUROPEAN UNION, REPRESENTED BY THE EUROPEAN COMMISSION (Brussels, Belgium) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitja Vahcic (Geel, Belgium); David Anderson (Brussels, Belgium); John Seghers (Ham, Belgium); Hanne Leys (Kasterlee, Belgium) |
| ABSTRACT | The present invention relates to a powdered simulant composition of an explosive compound having an Zeff, between 6.5 and 7.5 and a and the use thereof. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/770941 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/227 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20220389561 | SON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Kyung-Ah SON (Moorpark, California); Jeong-Sun MOON (Moorpark, California); Hwa Chang SEO (Malibu, California); Richard M. KREMER (Ramona, California); Ryan G. QUARFOTH (Malibu, California); Jack A. CROWELL (Malibu, California); Mariano J. TABOADA (Malibu, California); Joshua M. DORIA (Malibu, California); Terry B. WELCH (Malibu, California) |
| ABSTRACT | A process enables growing thick stoichiometric crystalline and preferably IR-transparent optical PCMO material on Si and other substrates. Sputter deposition is carried out in oxygen-free inert gas (e.g., Ar) environment, which helps to prevent decomposition of the PCMO material over the substrate. In the disclosed process, there is no need to add a seed layer prior to PCMO deposition. Moreover, no post-deposition annealing is needed in a high-temperature and high-pressure oxygen furnace, but an anneal provides certain additional benefits in terms of improved transparency at IR wavelengths. Over a long deposition time for a thick PCMO film on the high temperature (≥450° C.) substrates, the PCMO deposition is made repeated cycles of deposition of the PCMO material at the high temperature, each deposition cycle being followed by cooling the PCMO-deposited substrate to a substantially lower temperature (<50° C.). If an anneal is applied in a hydrogen environment that will cause hydrogenation of the PCMO film which yields PCMO films with an extremely small optical loss (i.e., optical extinction coefficient k<0.001) over the entire IR range. |
| FILED | Thursday, August 18, 2022 |
| APPL NO | 17/890913 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/08 (20130101) Original (OR) Class C23C 14/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220387380 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Rong LI (Washington, District of Columbia); Bin YUAN (Hefei City, China PRC); Tyler CURIEL (San Antonio, Texas) |
| ABSTRACT | The present invention provides methods and compositions for treating or preventing melanoma with S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule. |
| FILED | Monday, August 15, 2022 |
| APPL NO | 17/819863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220387360 | Haas |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eric Haas (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Haas (Houston, Texas) |
| ABSTRACT | Polymeric particles and scaffolds containing anesthetic agents, their use for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk, and methods of fabricating and administering polymeric particles containing anesthetic agents are described herein. |
| FILED | Tuesday, August 02, 2022 |
| APPL NO | 17/879169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/146 (20130101) A61K 9/1647 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 31/4458 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220390776 | Nikolov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anguel Nikolov (Culver City, California); Kurt W. Loheit (Rolling Hills Estates, California) |
| ABSTRACT | A method includes receiving light at a light input of an electro-optic modulator device. The method includes directing the light via the light input into optical waveguides in an optical layer of an electro-optic modulator of the electro-optic modulator device. The method includes receiving a signal at an electric input of the electro-optic modulator device. The electric input is associated with an input impedance. The method includes providing the signal to an electrode structure of the electro-optic modulator. The electrode structure generates an electrical field based on the signal. The electric field modulates light in the optical waveguides to produce modulated light based on the signal. The electrode structure includes a constant impedance section associated with a second impedance less than the input impedance. The method also includes providing the modulated light based on the signal from the optical layer to one or more output optic fibers. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/645535 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/035 (20130101) G02F 1/0311 (20130101) G02F 1/0316 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 08, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
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HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20221208.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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