FedInvent™ Patents

Patent Details for Tuesday, February 15, 2022 

This page was updated on Wednesday, February 16, 2022 at 09:25 AM GMT

Department of Health and Human Services (HHS) 

US 11246308 Brockbank et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Kelvin GM Brockbank (Charleston, South Carolina);  Lia H. Campbell (Mount Pleasant, South Carolina)
ABSTRACT Large volume cellular material may be preserved by combining the cellular material with a cryoprotectant formulation/medium/solution containing at least one sugar and then subjecting the cellular material to a vitrification preservation protocol.
FILED Friday, December 15, 2017
APPL NO 15/843462
ART UNIT 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246503 Lupton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) Myolex Inc (Brookline, Massachusetts)
ASSIGNEE(S) Myolex Inc. (Brookline, Massachusetts)
INVENTOR(S) Elmer C. Lupton (Charlestown, Massachusetts);  Haydn Taylor (Windham, New Hampshire);  Jose L. Bohorquez (Brookline, Massachusetts);  Ken Li (Wellesley, Massachusetts);  Michael Rinehart (San Jose, California)
ABSTRACT Embodiments of devices and methods for evaluating tissue are disclosed. In one embodiment, a method for measuring a characteristic of a tissue may include passing a current through the tissue, measuring a signal corresponding to the voltage resulting from passing the current through the tissue, analyzing current passed through the tissue and resulting voltage to determine the electrical characteristics of the tissue; and analyzing the electrical characteristics of the tissue to determine a status of the tissue. Disposable sensors are disclosed.
FILED Thursday, August 01, 2019
APPL NO 16/529725
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/053 (20130101) Original (OR) Class
A61B 5/486 (20130101)
A61B 5/0537 (20130101)
A61B 5/684 (20130101)
A61B 5/742 (20130101)
A61B 5/4519 (20130101)
A61B 5/6832 (20130101)
A61B 5/6833 (20130101)
A61B 5/6843 (20130101)
A61B 5/7221 (20130101)
A61B 5/7225 (20130101)
A61B 5/7228 (20130101)
A61B 5/7235 (20130101)
A61B 5/7278 (20130101)
A61B 5/7405 (20130101)
A61B 5/7475 (20130101)
A61B 2017/0023 (20130101)
A61B 2560/0412 (20130101)
A61B 2560/0431 (20130101)
A61B 2560/0443 (20130101)
A61B 2560/0468 (20130101)
A61B 2562/04 (20130101)
A61B 2562/14 (20130101)
A61B 2562/046 (20130101)
A61B 2562/164 (20130101)
A61B 2562/166 (20130101)
A61B 2562/0223 (20130101)

Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps
F04C 2270/041 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246504 Rutkove et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) Myolex Inc. (Brookline, Massachusetts)
ASSIGNEE(S) Myolex Inc. (Brookline, Massachusetts)
INVENTOR(S) Seward Rutkove (Brookline, Massachusetts);  Elmer C Lupton (Charlestown, Massachusetts);  Jose L. Bohorquez (Burlingame, California);  Haydn Taylor (Windham, New Hampshire);  Gonzalo Cespedes (Daly City, California);  Cary Liberman (Oakland, California);  Dmitri Khrebtukov (San Francisco, California);  Claudio Cassina (Hollywood, Florida);  Yensy Hall (Pembroke Pines, Florida);  Stanislava Daraskevich (San Francisco, California);  Juan Jaramillo (San Francisco, California)
ABSTRACT A portable device for measuring a bioimpedance-related property of tissue includes a plurality of electrodes arranged in a pattern on a surface and associated software for measuring bio-impedance related data of localized regions of tissue and calculate health-related parameters based on the measured data. These calculated parameters may be representative of muscular health of the localized tissue region.
FILED Monday, January 06, 2020
APPL NO 16/735648
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0004 (20130101)
A61B 5/486 (20130101)
A61B 5/0537 (20130101) Original (OR) Class
A61B 5/742 (20130101)
A61B 5/4519 (20130101)
A61B 5/4872 (20130101)
A61B 5/7278 (20130101)
A61B 2560/0425 (20130101)
A61B 2562/043 (20130101)
A61B 2562/0214 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246520 Clifford et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
National Institute of Mental Health (NIMH)
APPLICANT(S) Emory University (Atlanta, Georgia)
ASSIGNEE(S) EMORY UNIVERSITY (Atlanta, Georgia)
INVENTOR(S) Gari Clifford (Atlanta, Georgia);  Erik Reinertsen (Atlanta, Georgia);  Amit Shah (Atlanta, Georgia);  Shamim Nemati (Atlanta, Georgia)
ABSTRACT Systems, methods, and computer-readable media for classifying a PTSD status. In an embodiment, an example method for using a classifier can comprise receiving information from electrocardiography performed on an individual; determining features from the information; comparing the features to the a logistic regression classifier trained using features determined from median quiescent segments of RR interval information from individuals with and without PTSD, wherein the median quiescent segments are non-overlapping time periods of lowest median HR for each individual, and the features include one or more of the following: deceleration capacity (DC), low frequency (LF) power, very low frequency (VLF) power, and standard deviation of all normal RR intervals (SDNN); and determining a posttraumatic stress disorder (PTSD) status of the individual based on the comparison of the features to the classifier, wherein the PTSD status is a severity of PTSD based on a probability of PTSD.
FILED Wednesday, November 01, 2017
APPL NO 16/469001
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/024 (20130101)
A61B 5/165 (20130101) Original (OR) Class
A61B 5/316 (20210101)
A61B 5/352 (20210101)
A61B 5/7267 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246543 Tai et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) WASHINGTON UNIVERSITY (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Yuan-Chuan Tai (St. Louis, Missouri);  Jie Wen (St. Louis, Missouri);  Ke Li (St. Louis, Missouri);  Aswin John Mathews (St. Louis, Missouri)
ABSTRACT A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector panel, a tracking system configured to detect a position of said second detector panel relative to the first detector panel while imaging a subject, a computing device in communication with the first detector panel, the second detector panel, and the tracking system, the computing device configured to receive coincidence data from the first and second detector panels, receive position data from the tracking system, wherein each coincidence datum of the received coincidence data is associated with a unique position datum of the received position data, and reconstruct a plurality of images based on the received coincidence data and the received position data.
FILED Thursday, November 12, 2015
APPL NO 15/524699
ART UNIT 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 6/025 (20130101)
A61B 6/037 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/2985 (20130101)

Image Data Processing or Generation, in General
G06T 11/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246819 Koo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S) Hyun Koo (Philadelphia, Pennsylvania);  Henry Daniell (Media, Pennsylvania)
ABSTRACT The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm enzyme combinations, preferably in the form of a fusion protein. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides a composition for use in the treatment or prevention of a biofilm in a subject, particularly in the oral cavity.
FILED Friday, May 12, 2017
APPL NO 16/301023
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/40 (20130101)
A01N 65/38 (20130101)
A01N 65/385 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 8/21 (20130101)
A61K 8/66 (20130101)
A61K 8/0216 (20130101)
A61K 8/645 (20130101) Original (OR) Class
A61K 8/4926 (20130101)
A61K 9/0056 (20130101)
A61K 9/0058 (20130101)
A61K 38/47 (20130101)
A61K 38/168 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/02 (20180101)
A61P 31/04 (20180101)

Specific Use of Cosmetics or Similar Toilet Preparations
A61Q 11/00 (20130101)

Enzymes
C12Y 302/01003 (20130101)
C12Y 302/01011 (20130101)
C12Y 302/01059 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246829 Bellinger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Andrew Bellinger (Wellesley, Massachusetts);  Shiyi Zhang (Shanghai, China PRC);  Carlo Giovanni Traverso (Newton, Massachusetts);  Robert S. Langer (Newton, Massachusetts);  Stacy Mo (Darien, Illinois);  Tyler Grant (Arlington, Massachusetts);  Mousa Jafari (Waltham, Massachusetts);  Dean Liang Glettig (Cambridge, Massachusetts);  Angela DiCiccio (San Francisco, California);  Lowell L. Wood, Jr. (Bellevue, Washington);  Philip A. Eckhoff (Kirkland, Washington)
ABSTRACT Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.
FILED Thursday, June 11, 2020
APPL NO 16/899447
ART UNIT 1616 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/48 (20130101)
A61K 9/0053 (20130101)
A61K 9/0065 (20130101) Original (OR) Class
A61K 31/65 (20130101)
A61K 31/357 (20130101)
A61K 31/7048 (20130101)
A61K 47/10 (20130101)
A61K 47/32 (20130101)
A61K 47/34 (20130101)
A61K 47/40 (20130101)
A61K 47/42 (20130101)
A61K 47/58 (20170801)
A61K 47/6901 (20170801)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 31/002 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 18/73 (20130101)
C08G 18/4277 (20130101)
C08G 63/08 (20130101)
C08G 83/006 (20130101)
C08G 2230/00 (20130101)

Compositions of Macromolecular Compounds
C08L 33/02 (20130101)
C08L 33/08 (20130101)
C08L 33/14 (20130101)
C08L 2203/02 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246845 Chandraratna et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
National Cancer Institute (NCI)
APPLICANT(S) Io Therapeutics, Inc. (Houston, Texas);  Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S) Io Therapeutics, Inc. (Spring, Texas);  Trustees of Dartmouth College (Hanover, New Hampshire)
INVENTOR(S) Roshantha A. Chandraratna (San Juan Capistrano, California);  Ethan Dmitrovsky (Hanover, New Hampshire);  Elizabeth Nowak (West Lebanon, New Hampshire);  Randolph Noelle (Plainfield, New Hampshire)
ABSTRACT The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
FILED Friday, December 18, 2020
APPL NO 17/126787
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0073 (20130101)
A61K 31/47 (20130101)
A61K 31/192 (20130101) Original (OR) Class
A61K 31/201 (20130101)
A61K 31/216 (20130101)
A61K 31/343 (20130101)
A61K 31/353 (20130101)
A61K 31/4704 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246854 Boger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland);  UNIVERSITY OF NEBRASKA MEDICAL CENTER (Omaha, Nebraska)
ASSIGNEE(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland);  UNIVERSITY OF NEBRASKA MEDICAL CENTER (Omaha, Nebraska)
INVENTOR(S) Ravit Boger (Baltimore, Maryland);  Jonathan Vennerstrom (Omaha, Nebraska)
ABSTRACT Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.
FILED Tuesday, May 15, 2018
APPL NO 16/613258
ART UNIT 1627 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/357 (20130101) Original (OR) Class
A61K 31/4525 (20130101)
A61K 31/5377 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/22 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246856 Eckert et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S) University of Maryland, Baltimore (Baltimore, Maryland)
INVENTOR(S) Richard L. Eckert (Baltimore, Maryland);  Matthew Fisher (Smithtown, New York);  Daniel Grun (Derwood, Maryland);  Gautam Adhikary (Ellicott City, Maryland);  Wen Xu (Ellicott City, Maryland)
ABSTRACT Provided herein is a method for reducing resistance in an individual having a drug resistant cancer, for example, a BRAF inhibitor resistant cancer. A Hippo signaling pathway inhibitor such as a Yes-associated protein 1 (YAP1) inhibitor, a Transcriptional Coactivator with PDZ-binding motif (TAZ) inhibitor, a Transcription enhancer domain (TEAD) inhibitor or a combination of these is administered. Also provided is a method of treating BRAF inhibitor resistance in an individual with a BRAF inhibitor resistant cancer, for example, malignant melanoma, with a Hippo signaling pathway inhibitor, such as Verteporfin, and a BRAF inhibitor.
FILED Friday, May 18, 2018
APPL NO 16/614147
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/44 (20130101)
A61K 31/409 (20130101) Original (OR) Class
A61K 31/437 (20130101)
A61K 31/506 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246857 Bosch et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jürgen Bosch (Pikesville, Maryland);  Arturo Casadevall (Baltimore, Maryland);  Eric H. Jung (Baltimore, Maryland)
ABSTRACT Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans, or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.
FILED Wednesday, December 12, 2018
APPL NO 16/954004
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 31/167 (20130101)
A61K 31/403 (20130101)
A61K 31/4184 (20130101) Original (OR) Class
A61K 31/4196 (20130101)
A61K 38/17 (20130101)
A61K 38/1787 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/10 (20180101)
A61P 33/06 (20180101)

Peptides
C07K 14/47 (20130101)
C07K 14/70571 (20130101)
C07K 16/18 (20130101)
C07K 2317/622 (20130101)
C07K 2319/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246868 Aaronson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
ASSIGNEE(S) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York)
INVENTOR(S) Stuart A. Aaronson (New York, New York);  Albino Troilo (New York, New York);  Erica K. Benson (New York, New York)
ABSTRACT The present invention relates to a method of treating a tumor in a subject. This method involves administering to a subject having a Hippo pathway mutant tumor a tankyrase inhibitor, where the tumor is susceptible to treatment with the tankyrase inhibitor, and said administering is carried out to treat the tumor. The present invention also relates to a method of treating cancer in a subject, and a method of identifying a subject as a candidate for treatment.
FILED Wednesday, April 26, 2017
APPL NO 16/095784
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 10/02 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/33 (20130101)
A61K 31/095 (20130101)
A61K 31/352 (20130101)
A61K 31/495 (20130101)
A61K 31/505 (20130101)
A61K 31/506 (20130101)
A61K 31/513 (20130101) Original (OR) Class
A61K 31/519 (20130101)
A61K 31/7064 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/24 (20130101)
C07K 16/30 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/106 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246871 Surmeier, Jr. et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S) Northwestern University (Evanston, Illinois)
INVENTOR(S) Dalton James Surmeier, Jr. (Chicago, Illinois);  Weixing Shen (Wilmette, Illinois)
ABSTRACT Provided herein are compositions and methods for the treatment and of neurodegenerative disorders and levodopa-induced dyskinesias. In particular, A2a receptor antagonists are provided, as well as methods for the use of A2a receptor antagonists in the treatment of neurodegenerative disorders (e.g., Parkinsons disease) and the treatment and/or prevention levodopa-induced dyskinesias associated with such treatment.
FILED Friday, July 14, 2017
APPL NO 16/318067
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/198 (20130101)
A61K 31/198 (20130101)
A61K 31/519 (20130101)
A61K 31/522 (20130101) Original (OR) Class
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/14 (20180101)
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246877 Lin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois)
INVENTOR(S) Wenbin Lin (Chicago, Illinois);  Xiaopin Duan (Guangzhou, China PRC);  Christina Chan (Chicago, Illinois);  Wenbo Han (Chicago, Illinois)
ABSTRACT Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.
FILED Monday, May 22, 2017
APPL NO 16/302185
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/51 (20130101)
A61K 9/1277 (20130101)
A61K 31/66 (20130101) Original (OR) Class
A61K 31/136 (20130101)
A61K 31/337 (20130101)
A61K 31/357 (20130101)
A61K 31/475 (20130101)
A61K 31/704 (20130101)
A61K 31/4745 (20130101)
A61K 31/7048 (20130101)
A61K 31/7068 (20130101)
A61K 45/06 (20130101)
A61K 47/543 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)
C12N 2310/141 (20130101)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246880 Capaldi et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Arizona Board of Regents on Behalf of The University of Arizona (Tucson, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Arizona, Arizona)
INVENTOR(S) Andrew P. Capaldi (Tucson, Arizona);  James E. Hughes Hallett (Tucson, Arizona)
ABSTRACT Methods and compositions for activating TORC1 aggregate formation in a fungi or a parasite, wherein TORC1 aggregate formation inhibits growth of the fungi or parasite. TORC1 aggregate formation may be activated using small molecules or other agents, and said agents may be used to treat or prevent a disease or condition associated with the fungi and parasite. The agent may target Kog1 of TORC1, e.g., the agent may directly or indirectly inhibit Kog1 leading to aggregation of the TORC1 complex.
FILED Friday, December 18, 2015
APPL NO 15/535019
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/60 (20130101)
A61K 31/155 (20130101)
A61K 31/7056 (20130101) Original (OR) Class
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 2317/76 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 2500/10 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246881 Smith et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Georgetown University (Washington, District of Columbia);  The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  Georgetown University (Washington, District of Columbia)
INVENTOR(S) Jill P. Smith (Washington, District of Columbia);  Stephan Stern (Frederick, Maryland);  Abdullah Mahmud (Frederick, Maryland)
ABSTRACT A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
FILED Wednesday, March 15, 2017
APPL NO 16/084942
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 9/1075 (20130101)
A61K 9/5146 (20130101)
A61K 31/713 (20130101)
A61K 31/7088 (20130101) Original (OR) Class
A61K 47/10 (20130101)
A61K 47/60 (20170801)
A61K 47/183 (20130101)
A61K 47/6455 (20170801)
A61K 47/6935 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/115 (20130101)
C12N 2310/14 (20130101)
C12N 2310/16 (20130101)
C12N 2310/351 (20130101)
C12N 2320/30 (20130101)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246895 Balani et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
ASSIGNEE(S) Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
INVENTOR(S) Pooja Balani (Melrose, Massachusetts);  Felicitas Bidlack (Somerville, Massachusetts);  Xuesong He (Cypress, California);  Megan Pugach-Gordon (Medford, Massachusetts);  Wenyuan Shi (Boston, Massachusetts);  Jacqueline Starr (Lexington, Massachusetts);  Daniel Ferrer (Boston, Massachusetts)
ABSTRACT Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries.
FILED Friday, December 11, 2020
APPL NO 17/119933
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 6/00 (20130101)
A61K 35/747 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246908 Wu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) T. C. Wu (Stevenson, Maryland);  Chien-Fu Hung (Timonium, Maryland);  Brandon Krishna Lam (Baltimore, Maryland)
ABSTRACT The present invention provides a novel fusion protein of Flt3L and albumin and its use to increase the Flt3L half-life in vivo and to deliver Flt3L to immune cells in a subject to enhance alternative dendritic cell populations. Use of the fusion protein in combination with other chemotherapeutic, radiotherapeutic and immunotherapeutic methods are also provided.
FILED Thursday, January 10, 2019
APPL NO 16/244200
ART UNIT 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/18 (20130101)
A61K 38/19 (20130101)
A61K 38/38 (20130101)
A61K 38/1793 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/52 (20130101)
C07K 14/475 (20130101)
C07K 14/765 (20130101)
C07K 16/2827 (20130101)
C07K 19/00 (20130101)
C07K 2319/31 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/62 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246924 Collier et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Duke University (Durham, North Carolina);  Emory University (Atlanta, Georgia)
ASSIGNEE(S) Duke University (Durham, North Carolina);  Emory University (Atlanta, Georgia)
INVENTOR(S) Joel H. Collier (Durham, North Carolina);  Yaoying Wu (Durham, North Carolina);  Vincent P. Conticello (Atlanta, Georgia)
ABSTRACT Embodiments are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant.
FILED Friday, March 31, 2017
APPL NO 16/090561
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39 (20130101) Original (OR) Class
A61K 39/001104 (20180801)
A61K 47/646 (20170801)
A61K 2039/64 (20130101)
A61K 2039/575 (20130101)
A61K 2039/6031 (20130101)
A61K 2039/55516 (20130101)

Peptides
C07K 14/71 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246940 Tsien et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Roger Tsien (La Jolla, California);  Todd Aguilera (San Diego, California);  Emilia Olson (Seattle, Washington);  Tao Jiang (San Diego, California);  Quyen Nguyen (Del Mar, California)
ABSTRACT Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
FILED Friday, June 28, 2019
APPL NO 16/457763
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/60 (20170801)
A61K 47/62 (20170801)
A61K 47/64 (20170801) Original (OR) Class
A61K 47/595 (20170801)
A61K 47/6911 (20170801)
A61K 49/0032 (20130101)
A61K 49/0056 (20130101)

Peptides
C07K 7/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246942 Williams et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) City of Hope (Duarte, California)
ASSIGNEE(S) City of Hope (Duarte, California)
INVENTOR(S) John C. Williams (Duarte, California);  David A. Horne (Duarte, California);  Yuelong Ma (Duarte, California);  Heng Wei Chang (Foster City, California);  Joshua Michael Donaldson (Lumberton, New Jersey);  Cindy Zer (Duarte, California);  Krzysztof Bzymek (Pasadena, California);  Kendra Nicole Avery (Pasadena, California);  Jun Xie (Duarte, California)
ABSTRACT Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
FILED Monday, June 05, 2017
APPL NO 15/614468
ART UNIT 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/66 (20170801)
A61K 47/6811 (20170801) Original (OR) Class
A61K 47/6813 (20170801)
A61K 47/6851 (20170801)
A61K 47/6877 (20170801)
A61K 47/6897 (20170801)
A61K 51/1087 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 16/32 (20130101)
C07K 16/2863 (20130101)
C07K 2299/00 (20130101)
C07K 2317/34 (20130101)
C07K 2317/40 (20130101)
C07K 2317/55 (20130101)
C07K 2317/92 (20130101)
C07K 2317/567 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246946 Bradbury et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Memorial Sloan Kettering Cancer Center (New York, New York);  Cornell University (Ithaca, New York)
ASSIGNEE(S) Memorial Sloan Kettering Cancer Center (New York, New York);  Cornell University (Ithaca, New York)
INVENTOR(S) Michelle S. Bradbury (New York, New York);  Ulrich Wiesner (Ithaca, New York);  Michael Overholtzer (Glen Ridge, New Jersey);  Howard Scher (Tenafly, New Jersey);  Kai Ma (Ithaca, New York)
ABSTRACT Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
FILED Tuesday, June 16, 2020
APPL NO 16/902577
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/22 (20130101)
A61K 47/60 (20170801)
A61K 47/6923 (20170801)
A61K 47/6929 (20170801) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246956 Pokorski
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Jonathan Pokorski (San Diego, California)
ABSTRACT A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
FILED Monday, March 16, 2020
APPL NO 16/820158
ART UNIT 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/02 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 15/26 (20130101) Original (OR) Class
A61L 15/26 (20130101)
A61L 15/26 (20130101)
A61L 15/44 (20130101)
A61L 15/425 (20130101)
A61L 27/18 (20130101)
A61L 27/18 (20130101)
A61L 27/18 (20130101)
A61L 27/34 (20130101)
A61L 27/34 (20130101)
A61L 27/56 (20130101)
A61L 27/60 (20130101)
A61L 2400/12 (20130101)

Compositions of Macromolecular Compounds
C08L 67/04 (20130101)
C08L 67/04 (20130101)
C08L 71/02 (20130101)
C08L 71/02 (20130101)
C08L 71/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246965 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia)
ASSIGNEE(S) UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
INVENTOR(S) Shiyou Chen (Bogart, Georgia);  Rui Tang (Athens, Georgia)
ABSTRACT Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.
FILED Thursday, May 23, 2019
APPL NO 16/421148
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/00 (20130101)
A61K 31/42 (20130101)
A61K 31/198 (20130101)
A61K 31/4412 (20130101)
A61K 31/7068 (20130101)
A61K 31/7068 (20130101)
A61K 31/7072 (20130101)
A61K 35/74 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/54 (20130101)
A61L 27/507 (20130101)
A61L 31/08 (20130101)
A61L 31/16 (20130101) Original (OR) Class
A61L 2300/416 (20130101)
A61L 2300/434 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101)
C12N 2310/11 (20130101)
C12N 2310/12 (20130101)
C12N 2310/14 (20130101)
C12N 2310/16 (20130101)
C12N 2310/141 (20130101)
C12N 2310/531 (20130101)

Enzymes
C12Y 603/04002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247051 Jung et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Ranu Jung (Miami, Florida);  Ricardo Siu (Miami, Florida)
ASSIGNEE(S) THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S) Ranu Jung (Miami, Florida);  Ricardo Siu (Miami, Florida)
ABSTRACT Systems and methods for providing respiratory pacing using a closed-loop adaptive controller that can self-adjust in real-time to meet metabolic needs of a subject are provided. The controller can use an adaptive pattern generator/pattern shaper architecture that can autonomously generate a desired ventilatory pattern in response to dynamic changes in arterial carbon dioxide levels and, based on a learning algorithm or machine learning, can modulate stimulation intensity and cycle duration to evoke the desired ventilatory pattern.
FILED Wednesday, February 17, 2021
APPL NO 17/177650
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0836 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3601 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247181 Kaplan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
U.S. Navy
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Markus J. Buehler (Boxford, Massachusetts);  Shengjie Ling (Allston, Massachusetts)
ABSTRACT The present invention provides, inter alia, compositions including at least one pliable layer comprising a plurality of silk fibroin nanofibrils, and at least one rigid layer comprising a plurality of mineral crystals, wherein each rigid layer is associated with at least one pliable layer, as well as methods for the production and use thereof.
FILED Tuesday, October 24, 2017
APPL NO 16/344505
ART UNIT 1788 — Miscellaneous Articles, Stock Material
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/46 (20130101)
A61L 27/56 (20130101)
A61L 27/3604 (20130101)
A61L 2400/12 (20130101)

Separation
B01D 67/0079 (20130101)
B01D 69/12 (20130101)
B01D 69/144 (20130101) Original (OR) Class
B01D 71/02 (20130101)
B01D 71/74 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/44 (20130101)
C02F 2101/22 (20130101)

Mechanical Treatment of Natural Fibrous or Filamentary Material to Obtain Fibres of Filaments, e.g for Spinning
D01B 7/00 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/24996 (20150401)
Y10T 428/24998 (20150401)
Y10T 428/249953 (20150401)
Y10T 428/249954 (20150401)
Y10T 428/249964 (20150401)
Y10T 428/249979 (20150401)
Y10T 428/249981 (20150401)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247205 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
INVENTOR(S) Xuemin Wang (Tucson, Arizona);  Christopher Baker (Knoxville, Tennessee);  Craig A. Aspinwall (Tucson, Arizona)
ABSTRACT Surface-modified glass and polymer membrane interfaces form high-electrical resistance seals that can be used in microfluidic valves and array devices tailored for electrophysiological measurements. The incorporation of high seal resistance valves into the array device allows only the desired electrophysiological signal to be detected by a patch clamp amplifier, enabling parallel experiments with one patch clamp amplifier, which can greatly improve the cost efficiency. To achieve the desired high seal resistance, surface modification was performed on the glass components to increase the interaction between the glass and the membrane surfaces. The valves exhibit seal resistance of >500 GΩ after modification, which is 100× higher than reported for unmodified valves.
FILED Monday, April 16, 2018
APPL NO 15/953783
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101) Original (OR) Class
B01L 3/502715 (20130101)
B01L 3/502738 (20130101)
B01L 2200/027 (20130101)
B01L 2200/0689 (20130101)
B01L 2300/0645 (20130101)
B01L 2300/0663 (20130101)
B01L 2300/0887 (20130101)
B01L 2400/0638 (20130101)

Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating
F16K 99/0015 (20130101)
F16K 99/0042 (20130101)
F16K 2099/0073 (20130101)
F16K 2099/0074 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247970 Puigserver et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute on Drug Abuse (NIDA)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts);  The Scripps Research Institute (La Jolla, California);  The Broad Institute, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts);  The Scripps Research Institute (La Jolla, California);  The Broad Institute, Inc. (Cambridge, Massachusetts)
INVENTOR(S) Pere Puigserver (Brookline, Massachusetts);  Kfir Sharabi (Watertown, Massachusetts);  Theodore Kamenecka (Palm Beach Gardens, Florida);  Patrick Griffin (Jupiter, Florida);  Stuart L. Schreiber (Boston, Massachusetts);  Roger Schilling (Vineyard Haven, Massachusetts);  Partha P. Nag (Somerville, Massachusetts);  Joshua A. Bittker (Cambridge, Massachusetts)
ABSTRACT The present invention provides compounds, pharmaceutical compositions and methods for treating and/or preventing a metabolic condition, such as diabetes.
FILED Wednesday, March 21, 2018
APPL NO 16/496178
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)

Heterocyclic Compounds
C07D 207/09 (20130101)
C07D 209/08 (20130101)
C07D 223/28 (20130101) Original (OR) Class
C07D 333/34 (20130101)
C07D 401/04 (20130101)
C07D 401/12 (20130101)
C07D 405/12 (20130101)
C07D 495/04 (20130101)
C07D 498/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247971 Maloney et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland);  VANDERBILT UNIVERSITY (Nashville, Tennessee);  The UAB Research Foundation (Birmingham, Alabama);  The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  THE UAB RESEARCH FOUNDATION (Birmingham, Alabama);  VANDERBILT UNIVERSITY (Nashville, Tennessee);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S) David J. Maloney (Point of Rocks, Maryland);  Alex Gregory Waterson (Nashville, Tennessee);  Ganesh Rai Bantukallu (Arlington, Virginia);  Kyle Ryan Brimacombe (Bethesda, Maryland);  Plamen Christov (Nashville, Tennessee);  Chi V. Dang (Penn Valley, Pennsylvania);  Victor Darley-Usmar (Birmingham, Alabama);  Xin Hu (Frederick, Maryland);  Ajit Jadhav (Chantilly, Virginia);  Somnath Jana (Nashville, Tennessee);  Kwangho Kim (Nashville, Tennessee);  Jennifer L. Kouznetsova (Silver Spring, Maryland);  William J. Moore (Hagerstown, Maryland);  Bryan T. Mott (College Park, Maryland);  Leonard M. Neckers (Bethesda, Maryland);  Anton Simeonov (Bethesda, Maryland);  Gary Allen Sulikowski (Nashville, Tennessee);  Daniel Jason Urban (Rockville, Maryland);  Shyh Ming Yang (Doylestown, Pennsylvania)
ABSTRACT Provided is a compound of formula (I),
in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
FILED Thursday, January 28, 2021
APPL NO 17/160868
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/415 (20130101)
A61K 31/422 (20130101)
A61K 31/427 (20130101)
A61K 31/437 (20130101)
A61K 31/454 (20130101)
A61K 31/496 (20130101)
A61K 31/501 (20130101)
A61K 31/506 (20130101)
A61K 31/519 (20130101)
A61K 31/4155 (20130101)
A61K 31/4178 (20130101)
A61K 31/4439 (20130101)
A61K 31/5355 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 231/20 (20130101) Original (OR) Class
C07D 231/38 (20130101)
C07D 401/04 (20130101)
C07D 403/04 (20130101)
C07D 403/06 (20130101)
C07D 409/04 (20130101)
C07D 413/04 (20130101)
C07D 417/04 (20130101)
C07D 417/14 (20130101)
C07D 471/04 (20130101)
C07D 495/04 (20130101)
C07D 495/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247972 Van Voorhis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Washington through its Center for Commercialization (Seattle, Washington)
ASSIGNEE(S) University of Washington through its Center for Commercialization (Seattle, Washington)
INVENTOR(S) Wesley C. Van Voorhis (Seattle, Washington);  Wilhelmus G. J. Hol (Kenmore, Washington);  Eric T. Larson (Shoreline, Washington);  Dustin James Maly (Seattle, Washington);  Ethan Merritt (Seattle, Washington);  Kayode K. Ojo (Federal Way, Washington)
ABSTRACT Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.
FILED Friday, January 10, 2020
APPL NO 16/740095
ART UNIT 1629 — Organic Chemistry
CURRENT CPC
Heterocyclic Compounds
C07D 235/30 (20130101) Original (OR) Class
C07D 235/32 (20130101)
C07D 401/12 (20130101)
C07D 403/12 (20130101)
C07D 487/04 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247976 Blackwell et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Helen Blackwell (Middleton, Wisconsin);  Michelle E. Boursier (Madison, Wisconsin);  Joseph D. Moore (Wayne, Pennsylvania)
ABSTRACT RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-W-HG having various carbocyclic ad heterocyclic head groups (HG) and various tail groups (A), where —W— is —CO—NH—, —SO2—NH—, —CO—NH—CH2—, or —SO2—NH—CH2— are RhlR agonists or antagonists. The compounds are useful in methods of modulating quorum sensing in Gram-negative bacteria, particularly in Pseudomonas. Compositions including certain RhlR modulators are useful for decreasing the virulence of Gram-negative bacteria. Pharmaceutical compositions comprising certain RhlR modulators are useful for treatment of infections of Gram-negative bacteria.
FILED Sunday, April 30, 2017
APPL NO 16/097541
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 201/00 (20130101)
C07C 233/06 (20130101)
C07C 233/32 (20130101)
C07C 233/58 (20130101)
C07C 233/60 (20130101)
C07C 233/61 (20130101)
C07C 235/22 (20130101)
C07C 2601/04 (20170501)
C07C 2601/08 (20170501)

Heterocyclic Compounds
C07D 207/09 (20130101)
C07D 207/273 (20130101)
C07D 307/14 (20130101)
C07D 307/22 (20130101)
C07D 307/33 (20130101) Original (OR) Class
C07D 333/36 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247985 Huryn et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania);  National Institutes of Health, A Component of the United States Department of Health and Human Services (Bethesda, Maryland);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania);  National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services (Bethesda, Maryland);  The Regents of the University of California (Oakland, California)
INVENTOR(S) Donna M. Huryn (Allentown, New Jersey);  Peter Wipf (Pittsburgh, Pennsylvania);  Matthew G. LaPorte (Pittsburgh, Pennsylvania);  Raffaele Colombo (Pittsburgh, Pennsylvania);  Marina Kovaliov (Pittsburgh, Pennsylvania);  Chaemin Lim (Pittsburgh, Pennsylvania);  Celeste Natalie Alverez (Pittsburgh, Pennsylvania);  Zhizhou Yue (Pittsburgh, Pennsylvania);  Lalith Palitha Samankumara (Pittsburgh, Pennsylvania);  Alexander Julian Chatterley (Pittsburgh, Pennsylvania);  Yongzhao Yan (Pittsburgh, Pennsylvania);  Mary Liang (Pittsburgh, Pennsylvania);  Neal J. Green (Newton, Massachusetts);  Eric T. Baldwin (Upper Holland, Pennsylvania);  William J. Moore (Hagerstown, Maryland);  Michelle Arkin (San Francisco, California);  R. Jeffrey Neitz (Oakland, California);  Kean-Hooi Ang (Oakland, California);  Clifford Bryant (Oakland, California);  Stacie Bulfer (Oakland, California)
ABSTRACT The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
FILED Tuesday, January 21, 2020
APPL NO 16/748654
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 401/10 (20130101)
C07D 401/14 (20130101)
C07D 405/14 (20130101) Original (OR) Class
C07D 413/14 (20130101)
C07D 417/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247991 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Nathanael S. Gray (Boston, Massachusetts);  Tinghu Zhang (Brookline, Massachusetts);  Calla M. Olson (Brookline, Massachusetts);  Yanke Liang (Brookline, Massachusetts);  Nicholas Kwiatkowski (Auburn, Massachusetts)
ABSTRACT The present application provides bifunctional compounds of Formula (Ia) or (Ib):
or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8.
FILED Thursday, October 29, 2020
APPL NO 17/083940
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/18 (20130101)
A61K 47/545 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 471/04 (20130101) Original (OR) Class
C07D 471/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247996 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts);  University of Rochester (Rochester, New York)
ASSIGNEE(S) University of Massachusetts (Boston, Massachusetts);  University of Rochester (Rochester, New York)
INVENTOR(S) Wei Zhang (Boston, Massachusetts);  Jian Zhu (Boston, Massachusetts)
ABSTRACT The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. Related pharmaceutical compositions are disclosed. Methods of treatment with the disclosed compounds and compositions are also disclosed. Related kits are further disclosed.
FILED Friday, July 28, 2017
APPL NO 16/321589
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248012 Bazin-Lee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium)
ASSIGNEE(S) GLAXO SMIIHKLINE BIOLOGICALS SA (Rixensart, Belgium)
INVENTOR(S) Helene G. Bazin-Lee (Hamilton, Montana);  Laura S. Bess (Hamilton, Montana);  David A. Johnson (Hamilton, Montana)
ABSTRACT The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)-active and toll-like receptor (TLR8)-active imidazoquinolines and oxoadenines.
FILED Monday, August 10, 2020
APPL NO 16/989235
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 9/10 (20130101)
C07F 9/65583 (20130101) Original (OR) Class
C07F 9/65616 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248027 Schief et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) International AIDS Vaccine Initiative (New York, New York);  The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S) INTERNATIONAL AIDS VACCINE INITIATIVE (New York, New York);  THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S) William Schief (La Jolla, California);  Sergey Menis (New York, New York);  Daniel Kulp (New York, New York);  Joseph Jardine (La Jolla, California)
ABSTRACT The present invention relates to engineered outer domain (eOD) immunogens of HIV gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity. The mutant eODs bind to neutralizing antibody precursors. The mutant eODs can activate germline precursors on the pathway to eliciting a broadly neutralizing antibody (bnAb) response. The invention also relates to immunized knock-in mice expressing germline-reverted heavy chains. Induced antibodies showed characteristics of bnAbs and mutations that favored binding to near-native HIV-1 gp120 constructs. In contrast, native-like immunogens failed to activate precursors. The invention also relates to rational epitope design that can prime rare B cell precursors for affinity maturation to desired targets.
FILED Monday, December 18, 2017
APPL NO 15/844753
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0278 (20130101)
A01K 2207/15 (20130101)
A01K 2217/072 (20130101)
A01K 2227/105 (20130101)
A01K 2267/03 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/21 (20130101)
A61K 49/0008 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/00 (20130101)
C07K 2319/21 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 9/1085 (20130101)
C12N 2740/16122 (20130101)
C12N 2740/16134 (20130101)
C12N 2740/16171 (20130101)

Enzymes
C12Y 205/01078 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248028 Lieber et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
ASSIGNEE(S) UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington)
INVENTOR(S) Andre Lieber (Seattle, Washington);  Hongjie Wang (Seattle, Washington)
ABSTRACT The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
FILED Monday, March 02, 2020
APPL NO 16/806617
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/42 (20130101)

Peptides
C07K 7/06 (20130101)
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/74 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0652 (20130101)
C12N 7/00 (20130101)
C12N 15/10 (20130101)
C12N 15/86 (20130101)
C12N 2501/998 (20130101)
C12N 2506/00 (20130101)
C12N 2710/10022 (20130101)
C12N 2710/10033 (20130101)
C12N 2710/10321 (20130101)
C12N 2710/10322 (20130101)
C12N 2710/10333 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/94 (20130101)
G01N 2500/02 (20130101)
G01N 2500/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248034 Menting et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah);  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (Parkville, Australia)
ASSIGNEE(S) University of Utah Research Foundation (Salt Lake City, Utah);  The Walter and Eliza Hall Institute of Medical Research (Parksville, Australia)
INVENTOR(S) John Gerbrandt Tasman Menting (Bulleen, Australia);  Brian Smith (Bundoora, Australia);  Danny Hung-Chieh Chou (Salt Lake City, Utah);  Helena Safavi-Hemami (Salt Lake City, Utah);  Michael Colin Lawrence (Newport, Australia);  Baldomero M. Olivera (Salt Lake City, Utah)
ABSTRACT The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
FILED Friday, July 21, 2017
APPL NO 16/319450
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)

Peptides
C07K 14/62 (20130101) Original (OR) Class
C07K 14/43509 (20130101)
C07K 2299/00 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 7/02 (20130101)
C30B 29/58 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 15/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248036 Nelson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Christopher Nelson (St. Louis, Missouri);  Steven Teitelbaum (St. Louis, Missouri);  Daved Fremont (St. Louis, Missouri);  Julia T. Warren (St. Louis, Missouri)
ABSTRACT Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.
FILED Tuesday, December 17, 2019
APPL NO 16/717373
ART UNIT 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/70575 (20130101) Original (OR) Class
C07K 2319/00 (20130101)
C07K 2319/02 (20130101)
C07K 2319/21 (20130101)
C07K 2319/23 (20130101)
C07K 2319/30 (20130101)
C07K 2319/50 (20130101)
C07K 2319/74 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248038 Bidwell, III et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) University of Mississippi Medical Center (Jackson, Mississippi)
ASSIGNEE(S) University of Mississippi Medical Center (Jackson, Mississippi)
INVENTOR(S) Gene L. Bidwell, III (Brandon, Mississippi);  Alejandro R. Chade (Brandon, Mississippi)
ABSTRACT A renal cortex targeting elastin-like polypeptide (ELP), a renal medulla and cortex targeting ELP, and a method of treating a renal disorder are provided. The renal cortex targeting ELP includes up to 95 repeat units having the sequence VPGXG (SEQ ID NO: 1), where X in each of the repeat units is any amino acid except proline. The renal medulla and cortex targeting ELP includes at least 95 repeat units of SEQ ID NO: 1, where X in each of the repeat units is any amino acid except proline. The method of treating a renal disorder includes administering an ELP and a therapeutic drug to a subject in need thereof, where the ELP includes up to 671 repeat units of SEQ ID NO: 1 and X in each of the repeat units is any amino acid except proline.
FILED Monday, March 30, 2020
APPL NO 16/834549
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 13/12 (20180101)

Peptides
C07K 14/78 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248039 Saelens et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) VIB VZW (Ghent, Belgium);  UNIVERSITEIT GENT (Ghent, Belgium);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland);  TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S) VIB VZW (, None);  UNNVERSITEIT GENT (, None);  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland);  TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S) Xavier Saelens (Ypres, Belgium);  Bert Schepens (Drongen, Belgium);  Iebe Rossey (Gentbrugge, Belgium);  Barney Graham (Rockville, Maryland);  Jason McLellan (Norwich, Vermont);  Morgan Gilman (White River Junction, Vermont)
ABSTRACT The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.
FILED Tuesday, September 10, 2019
APPL NO 16/566542
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/505 (20130101)
A61K 2039/55561 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 16/1027 (20130101) Original (OR) Class
C07K 2317/22 (20130101)
C07K 2317/76 (20130101)
C07K 2317/565 (20130101)
C07K 2317/569 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2760/18534 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248213 Klemke et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (La Jolla, California)
ASSIGNEE(S) The Regents of the University of California (La Jolla, California)
INVENTOR(S) Richard Klemke (La Jolla, California);  Huawei Wang (San Diego, California)
ABSTRACT Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods.
FILED Wednesday, January 27, 2021
APPL NO 17/159595
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 35/12 (20130101)
A61K 35/28 (20130101)
A61K 38/2066 (20130101)
A61K 39/215 (20130101)
A61K 39/001102 (20180801)
A61K 2039/515 (20130101)
A61K 2039/545 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0662 (20130101) Original (OR) Class
C12N 15/85 (20130101)
C12N 2501/999 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248216 Thorner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Jeremy W. Thorner (Berkeley, California);  Gregory Charles Finnigan (San Francisco, California)
ABSTRACT The present disclosure provides genetically modified cells and non-human organisms, and methods of producing such cells and organisms. Also provided are methods of editing the genome of such cells and organisms. The cells and non-human organisms of the disclosure are genetically modified such that their genome includes an integrated heterologous nucleic acid (that includes a CRISPR/Cas target sequence) at one or more (e.g., 2 or more, 3 or more, 4 or more, etc.) positions within the genome. The integrated nucleic acids, which include the same CRISPR/Cas target sequence, allow for simultaneous gene editing at multiple different positions within a genome using a single species of CRISPR/Cas guide RNA (i.e., one guide RNA will target multiple sites because the multiple sites have the same target sequence).
FILED Thursday, April 20, 2017
APPL NO 16/090119
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/09 (20130101)
C12N 15/11 (20130101)
C12N 15/79 (20130101)
C12N 15/81 (20130101)
C12N 15/90 (20130101)
C12N 15/102 (20130101)
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248218 Dong et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Children's Medical Center Corporation (Boston, Massachusetts);  Paul Stenmark (Stockholm, Sweden)
ASSIGNEE(S) Children's Medical Center Corporation (Boston, Massachusetts)
INVENTOR(S) Min Dong (Weatogue, Connecticut);  Sicai Zhang (Boston, Massachusetts);  Paul Stenmark (Stockholm, Sweden)
ABSTRACT Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.
FILED Friday, July 07, 2017
APPL NO 16/315698
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/00 (20130101)

Peptides
C07K 14/33 (20130101)
C07K 2319/01 (20130101)
C07K 2319/21 (20130101)
C07K 2319/22 (20130101)
C07K 2319/23 (20130101)
C07K 2319/24 (20130101)
C07K 2319/035 (20130101)
C07K 2319/41 (20130101)
C07K 2319/42 (20130101)
C07K 2319/43 (20130101)
C07K 2319/50 (20130101)
C07K 2319/55 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/52 (20130101) Original (OR) Class

Enzymes
C12Y 304/24069 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248270 Bowers et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (Phoenix, Arizona);  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (Flagstaff, Arizona)
ASSIGNEE(S) The Translational Genomics Research Institute (Phoenix, Arizona);  Arizona Board of Regents on behalf of Northern Arizona University (Flagstaff, Arizona)
INVENTOR(S) Jolene Bowers (Flagstaff, Arizona);  Elizabeth Driebe (Flagstaff, Arizona);  David Engelthaler (Flagstaff, Arizona);  Paul Keim (Flagstaff, Arizona);  Darrin Lemmer (Flagstaff, Arizona)
ABSTRACT The present invention provides a method of detecting one or more Klebsiella species within a sample from a subject, the method comprising: subjecting DNA and/or RNA from the sample to a PCR amplification reaction using primer pairs targeting species-specific canonical single nucleotide polymorphisms (canSNPs); and analyzing amplification products resulting from the PCR amplification reaction to detect the one or more Klebsiella species. The present invention also provides a kit for detection of one or more Klebsiella species, Klebsiella clonal groups, AMR genes, and/or virulence genes, the kit comprising primer pairs targeting species-specific canSNPs, K. pneumoniae genes M1 and M2, clonal group-specific canSNPs, AMR genes, and/or virulence genes.
FILED Tuesday, March 14, 2017
APPL NO 16/083860
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
C12Q 1/689 (20130101) Original (OR) Class
C12Q 1/6827 (20130101)
C12Q 1/6853 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248272 Yang et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Genyan Yang (Tucker, Georgia);  Charles Todd Davis (Decatur, Georgia)
ABSTRACT Disclosed herein are methods for detecting presence of a target nucleic acid (such as an influenza virus nucleic acid) in a sample. In some embodiments, the methods include contacting the sample with a first probe capable of hybridizing to the target nucleic acid and a second probe capable of hybridizing to the target nucleic acid, contacting the resulting complex with one or more gap filling reagents, thereby producing a gap-filled target nucleic acid, isolating and amplifying the gap-filled target nucleic acid. The amplified gap-filled target nucleic acid covalently linked to the substrate is then detected, for example with a detectably labeled probe. Also disclosed herein are probes capable of hybridizing to influenza virus nucleic acids. The disclosure also includes kits for detecting and/or discriminating influenza virus nucleic acids in a sample. In some examples, the kits include two or more of the disclosed probes.
FILED Friday, June 23, 2017
APPL NO 16/313330
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/70 (20130101)
C12Q 1/686 (20130101)
C12Q 1/701 (20130101) Original (OR) Class
C12Q 1/6806 (20130101)
C12Q 1/6816 (20130101)
C12Q 1/6816 (20130101)
C12Q 2525/155 (20130101)
C12Q 2531/113 (20130101)
C12Q 2537/143 (20130101)
C12Q 2563/143 (20130101)
C12Q 2565/1015 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/166 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249000 Barrett et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona);  inviCro, LLC (Boston, Massachusetts)
ASSIGNEE(S) Arizona Board of Regents on Behalt of the University of Arizona (Tucson, Arizona);  inviCro, LLC (Boston, Massachusetts)
INVENTOR(S) Harrison H. Barrett (Tucson, Arizona);  Yijun Ding (Tucson, Arizona);  Luca Caucci (Tucson, Arizona);  John William Hoppin (Boston, Massachusetts)
ABSTRACT The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.
FILED Tuesday, October 15, 2019
APPL NO 16/653922
ART UNIT 2699 — Search and Capture Special Detail
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/037 (20130101)
A61B 6/4241 (20130101)
A61B 6/4258 (20130101)
A61B 6/5205 (20130101)

Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 7/004 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/02 (20130101)
G01N 15/0227 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/2942 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249004 Vacca et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Kinetic River Corp. (Mountain View, California)
ASSIGNEE(S) KINETIC RIVER CORP. (Mountain View, California)
INVENTOR(S) Giacomo Vacca (Campbell, California);  Ralph Jimenez (Boulder, Colorado)
ABSTRACT Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.
FILED Monday, March 22, 2021
APPL NO 17/209057
ART UNIT 2878 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/14 (20130101) Original (OR) Class
G01N 15/147 (20130101)
G01N 15/1429 (20130101)
G01N 15/1434 (20130101)
G01N 15/1436 (20130101)
G01N 2015/144 (20130101)
G01N 2015/149 (20130101)
G01N 2015/1006 (20130101)
G01N 2015/1438 (20130101)
G01N 2015/1477 (20130101)
G01N 2015/1488 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249071 Guttman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Mitchell Guttman (Los Angeles, California);  Chun-Kan Chen (Alhambra, California);  Colleen A. McHugh (Altadena, California)
ABSTRACT Methods of prohibiting Xist-dependent silencing of X chromosome genes include targeting the required Xist silencing complex components including SHARP, SMRT, HDAC3, SAF-A, LBR, and the respective binding sites of SHARP, LBR, and SAF-A on Xist, thereby prohibiting Xist repression, allowing for reactivation of the silenced X chromosome genes.
FILED Monday, April 25, 2016
APPL NO 15/138208
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249086 Chiu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Washington (Seattle, Washington);  Clemson University Research Foundation (Clemson, South Carolina)
ASSIGNEE(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S) Daniel T. Chiu (Seattle, Washington);  Changfeng Wu (Changchun, China PRC);  Jason McNeill (Clemson, South Carolina);  Jiangbo Yu (Bothell, Washington)
ABSTRACT The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
FILED Tuesday, December 04, 2018
APPL NO 16/209729
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/582 (20130101)
G01N 33/587 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249091 Hazen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Non-Profit Organization (NPO)
The Cleveland Clinic Foundation
APPLICANT(S) The Cleveland Clinic Foundation (Cleveland, Ohio)
ASSIGNEE(S) The Cleveland Clinic Foundation (Cleveland, Ohio)
INVENTOR(S) Stanley L. Hazen (Pepper Pike, Ohio);  Zeneng Wang (Shaker Heights, Ohio)
ABSTRACT The present invention to provides methods, kits, and compositions for: i) detecting the level of 3-bromotyrosine in a sample that has been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine, and/or ii) detecting the level of 4-O-glucuronide-3-bromotyrosine, and/or the combined level of both 4-O-glucuronide-3-bromotyrosine and 3-bromotyrosine, in a sample that has not been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine. In certain embodiments, such detected levels are used to: i) identify the presence, severity, or risk of an eosinophilic disorder (e.g., asthma or a TH2-high eosinophilic disorder); ii) identify therapy effective for treating asthma or an eosinophilic disorder; or iii) identify patients suitable for treatment with therapeutic agents targeted to asthma or an eosinophilic disorder.
FILED Thursday, February 21, 2019
APPL NO 16/281811
ART UNIT 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
G01N 2800/122 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249092 Soto-Jara et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Amprion, Inc. (San Francisco, California);  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S) Amprion, Inc. (San Francisco, California)
INVENTOR(S) Claudio Soto-Jara (Friendswood, Texas);  Russell M. Lebovitz (Oakland, California);  Benedikt K. Vollrath (San Diego, California);  Mohammad Shahnawaz (Houston, Texas);  Nicolas Mendez Dinamarca (Houston, Texas)
ABSTRACT Methods and kits are provided for amplifying and detecting misfolded tau protein from samples, for example, from patients having tauopathies such as Alzheimer's Disease, Progressive Supranuclear Palsy, and the like.
FILED Wednesday, May 16, 2018
APPL NO 15/981449
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6896 (20130101) Original (OR) Class
G01N 2333/47 (20130101)
G01N 2333/4709 (20130101)
G01N 2800/2821 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249094 Wanner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Ina-Beate Wanner (Topanga, California);  Joseph A. Loo (Encino, California)
ABSTRACT A method for detection or monitoring status of traumatic brain injury (TBI) and/or spinal cord injury (SCI) in a subject is provided. In one embodiment, the method comprises contacting a specimen of bodily fluid obtained from the subject with reagents for assaying for a marker of TBI selected from aldolase C (ALDOC) and brain lipid binding protein (BLBP/FABP7), or a trauma-specific break down product (BDP) of ALDOC or BLBP/FABP7. The method further comprises measuring the amount of marker present in the specimen as compared to a control sample, and determining the presence of TBI or SCI when an elevated amount of marker is present in the specimen compared to the control sample. Optionally, the method further comprises measuring the amount of glutamine synthetase (GS), astrocytic phosphoprotein PEA-15 (PEA15), αB-crystallin (CRYAB/HSP27), a trauma-specific proteolytic cleavage product of ALDOC, GS, PEA15, or CRYAB, or any combination of two or more thereof.
FILED Monday, December 16, 2019
APPL NO 16/716095
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Enzymes
C12Y 201/01259 (20150701)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/577 (20130101)
G01N 33/6848 (20130101)
G01N 33/6896 (20130101) Original (OR) Class
G01N 2800/40 (20130101)
G01N 2800/52 (20130101)
G01N 2800/2871 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249161 Van Zijl et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland);  Kennedy Krieger Institute (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland);  Kennedy Krieger Institute (Baltimore, Maryland)
INVENTOR(S) Peter Van Zijl (Hanover, Maryland);  Nirbhay Yadav (Baltimore, Maryland)
ABSTRACT A method to detect transient binding of a substrate molecule of interest in solution to a molecular target includes selecting the substrate molecule of interest and the molecular target such that the substrate molecule of interest can transiently bind to the molecular target; placing one of a sample or a subject of interest in a magnetic resonance (MR) apparatus, the sample or the subject of interest containing the substrate molecule of interest so as to be in contact with the molecular target; providing magnetic labelling of non-exchangeable or slowly exchangeable MR sensitive nuclei of the substrate molecule of interest; receiving an MR signal from the MR sensitive nuclei of the solvent molecules using the MR apparatus; and analyzing the MR signal to obtain a quantity associated with the transient binding of the substrate molecule of interest to the molecular target.
FILED Friday, March 02, 2018
APPL NO 16/490219
ART UNIT 2852 — Printing/Measuring and Testing
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/465 (20130101)
G01R 33/4608 (20130101)
G01R 33/4616 (20130101)
G01R 33/5605 (20130101) Original (OR) Class
G01R 33/5608 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251031 Saeed et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Fahad Saeed (Miami, Florida);  Muhammad Usman Tariq (Miami, Florida)
ASSIGNEE(S) THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (Miami, Florida)
INVENTOR(S) Fahad Saeed (Miami, Florida);  Muhammad Usman Tariq (Miami, Florida)
ABSTRACT Systems and methods for measuring cross-modal similarity between mass spectra and peptides are provided. A deep learning network can be used and, by training on a variety of labeled spectra, the network can embed both spectra and peptides onto a Euclidean subspace where the similarity is measured by the L2 distance between different points. The network can be trained on a novel loss function, which can calculate the gradients from sextuplets of data points.
FILED Friday, June 04, 2021
APPL NO 17/339070
ART UNIT 2881 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6848 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/0036 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252517 Cantu
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Marcos Antonio Cantu (Rancho Viejo, Texas)
ASSIGNEE(S)
INVENTOR(S) Marcos Antonio Cantu (Oldenburg, Germany)
ABSTRACT An assistive listening device includes a set of microphones including an array arranged into pairs about a nominal listening axis with respective distinct intra-pair microphone spacings, and a pair of ear-worn loudspeakers. Audio circuitry performs arrayed-microphone short-time target cancellation processing including (1) applying short-time frequency transforms to convert time-domain audio input signals into frequency-domain signals for every short-time analysis frame, (2) calculating ratio masks from the frequency-domain signals of respective microphone pairs, wherein the calculation of a ratio mask includes both a frequency domain subtraction of signal values of a microphone pair and a scaling of a resulting frequency domain noise estimate by a pre-computed phase difference normalization vector, (3) calculating a global ratio mask from the plurality of ratio masks, and (4) applying the global ratio mask, and inverse short-time frequency transforms, to selected ones of the frequency-domain signals, thereby generating audio output signals for driving the loudspeakers. The circuitry and processing may also be realized in a machine hearing device executing a human-computer interface application.
FILED Monday, October 05, 2020
APPL NO 16/948902
ART UNIT 2651 — Videophones and Telephonic Communications
CURRENT CPC
Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for
G10K 11/17823 (20180101)
G10K 11/17857 (20180101)
G10K 11/17873 (20180101)
G10K 11/17885 (20180101)
G10K 2210/111 (20130101)
G10K 2210/1081 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 21/0208 (20130101)
G10L 2021/02166 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 1/406 (20130101)
H04R 3/005 (20130101)
H04R 5/027 (20130101)
H04R 25/48 (20130101) Original (OR) Class
H04R 25/405 (20130101)
H04R 25/407 (20130101)

Stereophonic Systems
H04S 7/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US RE48928 Strongin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
APPLICANT(S) Portland State University (Portland, Oregon)
ASSIGNEE(S) Portland State University (Portland, Oregon)
INVENTOR(S) Robert Strongin (Portland, Oregon);  Martha Sibrian-Vazquez (Portland, Oregon);  Jialu Wang (Portland, Oregon);  Lei Wang (Camas, Washington);  Jorge O. Escobedo-Cordova (Portland, Oregon)
ABSTRACT Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.
FILED Friday, April 24, 2020
APPL NO 16/858380
ART UNIT 3991 — Central Reexamination Unit (Chemical)
CURRENT CPC
Heterocyclic Compounds
C07D 491/22 (20130101)
C07D 491/107 (20130101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 11/24 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/92 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 11246308 Brockbank et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Kelvin GM Brockbank (Charleston, South Carolina);  Lia H. Campbell (Mount Pleasant, South Carolina)
ABSTRACT Large volume cellular material may be preserved by combining the cellular material with a cryoprotectant formulation/medium/solution containing at least one sugar and then subjecting the cellular material to a vitrification preservation protocol.
FILED Friday, December 15, 2017
APPL NO 15/843462
ART UNIT 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246518 Qiang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Telemedicine and Advanced Technology Research Center (TATRC)
APPLICANT(S) The University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S) UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (Farmington, Connecticut)
INVENTOR(S) Liangliang Qiang (Willimantic, Connecticut);  Santhisagar Vaddiraju (Willimantic, Connecticut);  Fotios Papadimitrakopoulos (West Hartford, Connecticut)
ABSTRACT Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.
FILED Monday, June 03, 2019
APPL NO 16/429684
ART UNIT 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/1473 (20130101)
A61B 5/1495 (20130101)
A61B 5/14532 (20130101)
A61B 5/14865 (20130101) Original (OR) Class
A61B 2560/0223 (20130101)
A61B 2562/04 (20130101)
A61B 2562/028 (20130101)
A61B 2562/125 (20130101)
A61B 2562/0285 (20130101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 5/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246729 Blanck
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) The Government of the United States As Represented By the Secretary of the Army (Fort Detrick, Maryland)
ASSIGNEE(S) The Government of the United States as represented by the Secretary of the Army (Fort Detrick, Maryland)
INVENTOR(S) Ryan Vaughn Blanck (Gig Harbor, Washington)
ABSTRACT An exoskeletal orthosis includes a proximal cuff including a hinge along an upper edge of the cuff; an ankle section/footplate; and at least one posterior strut connecting the proximal cuff to the ankle section and foot plate.
FILED Friday, March 23, 2018
APPL NO 15/934093
ART UNIT 3786 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 5/0125 (20130101)
A61F 5/0127 (20130101) Original (OR) Class
A61F 2005/0179 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246940 Tsien et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Roger Tsien (La Jolla, California);  Todd Aguilera (San Diego, California);  Emilia Olson (Seattle, Washington);  Tao Jiang (San Diego, California);  Quyen Nguyen (Del Mar, California)
ABSTRACT Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
FILED Friday, June 28, 2019
APPL NO 16/457763
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/60 (20170801)
A61K 47/62 (20170801)
A61K 47/64 (20170801) Original (OR) Class
A61K 47/595 (20170801)
A61K 47/6911 (20170801)
A61K 49/0032 (20130101)
A61K 49/0056 (20130101)

Peptides
C07K 7/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247181 Kaplan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
U.S. Navy
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) David L. Kaplan (Concord, Massachusetts);  Markus J. Buehler (Boxford, Massachusetts);  Shengjie Ling (Allston, Massachusetts)
ABSTRACT The present invention provides, inter alia, compositions including at least one pliable layer comprising a plurality of silk fibroin nanofibrils, and at least one rigid layer comprising a plurality of mineral crystals, wherein each rigid layer is associated with at least one pliable layer, as well as methods for the production and use thereof.
FILED Tuesday, October 24, 2017
APPL NO 16/344505
ART UNIT 1788 — Miscellaneous Articles, Stock Material
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/46 (20130101)
A61L 27/56 (20130101)
A61L 27/3604 (20130101)
A61L 2400/12 (20130101)

Separation
B01D 67/0079 (20130101)
B01D 69/12 (20130101)
B01D 69/144 (20130101) Original (OR) Class
B01D 71/02 (20130101)
B01D 71/74 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/44 (20130101)
C02F 2101/22 (20130101)

Mechanical Treatment of Natural Fibrous or Filamentary Material to Obtain Fibres of Filaments, e.g for Spinning
D01B 7/00 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/24996 (20150401)
Y10T 428/24998 (20150401)
Y10T 428/249953 (20150401)
Y10T 428/249954 (20150401)
Y10T 428/249964 (20150401)
Y10T 428/249979 (20150401)
Y10T 428/249981 (20150401)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247377 Fossey et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) U.S. Government as Represented by the Secretary of the Army (Natick, Massachusetts)
ASSIGNEE(S) U.S. Government as Represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S) Stephen A. Fossey (Framingham, Massachusetts);  Barry S. DeCristofano (Plympton, Massachusetts)
ABSTRACT Methods and computer-readable mediums are provide that, in some embodiments maximize bending of an actuator and, in other embodiments, minimize bending of the actuator. For example, in one embodiment, a method is provided that acquires a first ratio of a modulus of inertia for a first component to a Young's Modulus for the first component. The method also acquires a second ratio of a modulus of inertia for a second component to a Young's Modulus for the second component. Thereafter, the method provides an actuator (which includes the first component and second component). The actuator has a cross-sectional shape such that the first ratio substantially equal to said second ratio. In various embodiments of the invention, the actuator is spun fibers formed into batting and used as insulation, or may form an active element of a thermostat.
FILED Tuesday, September 10, 2019
APPL NO 16/565539
ART UNIT 1789 — Miscellaneous Articles, Stock Material
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 48/19 (20190201) Original (OR) Class

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2023/14 (20130101)
B29K 2067/00 (20130101)
B29K 2067/003 (20130101)
B29K 2069/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247915 Vaia et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Richard A. Vaia (Beavercreek, Ohio);  Ali M. Jawaid (Fairborn, Ohio)
ABSTRACT A technique for exfoliating a transition metal dichalcogenide material to produce separated nano-scale platelets includes combining the transition metal dichalcogenide material with a liquid to form a slurry, wherein the transition metal dichalcogenide material includes layers of nano-scale platelets and has a general chemical formula MX2, and wherein M is a transition metal and X is sulfur, selenium, or tellurium. The slurry of the transition metal dichalcogenide material is treated with an oxidant to form peroxo-metalate intermediates on an edge region of the layers of nano-scale platelets of the transition metal dichalcogenide material. The peroxo-metalate intermediates is treated with a reducing agent to form negatively charged poly-oxo-metalates to induce separation of the transition metal dichalcogenide material into the separated nano-scale platelets of the transition metal dichalcogenide material.
FILED Tuesday, July 30, 2019
APPL NO 16/526161
ART UNIT 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 19/04 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 39/06 (20130101) Original (OR) Class
C01G 47/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247974 Evseenko et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Denis Evseenko (Tarzana, California);  Benjamin J. Van Handel (Los Angeles, California);  Varghese John (Los Angeles, California)
ABSTRACT There are provided, inter alia, methods and compounds for activating a proliferative program in competent adult chondrocytes.
FILED Friday, December 07, 2018
APPL NO 16/213958
ART UNIT 1628 — Organic Chemistry
CURRENT CPC
Heterocyclic Compounds
C07D 277/42 (20130101) Original (OR) Class
C07D 417/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248125 Benkoski et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Jason J. Benkoski (Catonsville, Maryland);  Christopher M. Hoffman, Jr. (Odenton, Maryland);  Rengaswamy Srinivasan (Ellicott City, Maryland);  Keith S. Caruso (Catonsville, Maryland)
ABSTRACT A coating system may be configured to be applied to an aluminum-magnesium substrate of an object. The coating system may include a primer configured to reduce the corrosion rate of the aluminum-magnesium substrate and a topcoat configured to resist water and improve solar reflectance of the coating system. The primer may include a silicate and a first additive configured to increase corrosion resistance of the coating system The topcoat may include a siloxane and a second additive configured to reduce solar absorptance of the coating system.
FILED Thursday, March 29, 2018
APPL NO 15/939345
ART UNIT 1787 — Miscellaneous Articles, Stock Material
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 2003/265 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 1/02 (20130101)
C09D 1/04 (20130101)
C09D 5/002 (20130101) Original (OR) Class
C09D 5/004 (20130101)
C09D 5/084 (20130101)
C09D 5/086 (20130101)
C09D 7/60 (20180101)
C09D 7/61 (20180101)
C09D 7/63 (20180101)
C09D 7/65 (20180101)
C09D 183/04 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 3/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248313 Omenetto et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S) Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S) Fiorenzo G. Omenetto (Lexington, Massachusetts);  Peter Tseng (Saratoga, California)
ABSTRACT This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.
FILED Tuesday, August 01, 2017
APPL NO 16/319468
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/227 (20130101)
A61L 2400/12 (20130101)

Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems
B81C 99/0085 (20130101)

Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof
B82B 1/002 (20130101)
B82B 3/0023 (20130101)
B82B 3/0038 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/00 (20130101)
D01F 4/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248351 Johnson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) United States of America as Represented by The Secretary of The Army (Alexandria, Virginia)
ASSIGNEE(S) UNITED STATES of AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia)
INVENTOR(S) August N Johnson (Raymond, Mississippi);  Bowen G Woodson (Clinton, Mississippi);  Austin C Hopkins (Vicksburg, Mississippi)
ABSTRACT In one embodiment, a deployable barrier container apparatus includes: in folded position, a container and, in unfolded position, a vertical barrier component is deployable on a base placed on the ground to oppose vehicle traffic approaching from an upstream side. A second side wall and a ceiling top are disposed on the downstream side of the base. A first side wall and a stowed top are disposed on the upstream side of the base and on which approaching vehicles move. The horizontal barrier component is disposed upstream of the stowed top and on which the approaching vehicles move, and the horizontal barrier component comprises an elongated sliding friction mat which creates a sliding friction interface with the ground upon contact of a moving vehicle with the deployed vertical barrier component in the deployed position. The base, side walls, and tops are rotatably connected to unfold to form the barrier apparatus.
FILED Tuesday, August 11, 2020
APPL NO 16/990692
ART UNIT 3671 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like
E01F 13/02 (20130101)
E01F 13/048 (20130101)
E01F 13/123 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248485 Baldiga et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) GENERAL ELECTRIC COMPANY (Schenectady, New York)
INVENTOR(S) Jonathan D. Baldiga (Lynn, Massachusetts);  David W. Bogdan (Lynn, Massachusetts)
ABSTRACT Example apparatus, systems, and articles of manufacture to control deflection mismatch are disclosed herein. Further examples and combinations thereof include: A deflection limiter comprising an inner shroud segment to support a stator structure, the inner shroud segment including a first end face and a first outer upper portion, the first end face positioned radially inward and aft relative to the first outer upper portion, and an outer shroud segment to support the inner shroud segment, the outer shroud segment including a second end face and a second outer upper portion, the second end face positioned aft relative to the first end face and the second outer upper portion positioned aft relative to the first outer upper portion of the inner shroud segment, the second end face coupled to the first end face of the inner shroud segment and the second outer upper portion coupled to the first outer upper portion.
FILED Monday, August 17, 2020
APPL NO 16/995467
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/12 (20130101)
F01D 9/00 (20130101)
F01D 11/08 (20130101)
F01D 11/14 (20130101)
F01D 11/18 (20130101)
F01D 11/22 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/323 (20130101)
F05D 2240/11 (20130101)
F05D 2240/12 (20130101)
F05D 2240/55 (20130101)
F05D 2240/60 (20130101)
F05D 2270/303 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248538 Robertson, Jr. et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
United States Air Force (USAF)
APPLICANT(S) United Technologies Corporation (Hartford, Connecticut)
ASSIGNEE(S) Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S) Thomas J. Robertson, Jr. (Glastonbury, Connecticut);  Nathan F. Champion (Enfield, Connecticut);  Steven J. Feigleson (Falmouth, Maine)
ABSTRACT A split case assembly for a gas turbine engine includes an outer diameter case defining a partial case structure for a gas turbine engine and multiple fixed-variable vanes attached to an inner diameter surface of the outer diameter case. Each of the fixed-variable vanes protrudes radially inward from the outer diameter case. Each of the fixed-variable vanes in the plurality of fixed-variable vanes is interfaced with one of a plurality of inner diameter boxes at a radially inward end of the fixed-variable vane, such that the inner diameter boxes define an inner diameter of a flow path and the outer diameter case defines an outer diameter flow path. Each of the fixed-variable vanes are interfaced with the one of the plurality of inner diameter boxes through at least one inner diameter shoe in a plurality of inner diameter shoes.
FILED Friday, September 18, 2015
APPL NO 14/857886
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 9/02 (20130101)
F01D 9/041 (20130101)
F01D 9/042 (20130101)
F01D 9/047 (20130101)
F01D 17/14 (20130101)
F01D 25/24 (20130101)
F01D 25/26 (20130101)
F01D 25/246 (20130101)
F01D 25/265 (20130101)

Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 3/04 (20130101)
F02C 7/32 (20130101)
F02C 9/54 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/32 (20130101)
F05D 2230/60 (20130101)
F05D 2240/12 (20130101)
F05D 2240/24 (20130101)
F05D 2240/35 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248560 Simpson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
United States Air Force (USAF)
APPLICANT(S) UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S) RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S) Alex J. Simpson (Tolland, Connecticut);  Robert T. Knowlton (Newington, Connecticut)
ABSTRACT Disclosed is a linkage assembly for a gas turbine engine having a link having a first end, a second end, and a rod extending therebetween, the first end having a first sliding bearing disposed within a first sliding bearing housing, a fastener comprising a first flange and a second flange, a pin extending between the first flange and the second flange, wherein the first sliding bearing is pivotally connected to the pin; and a biasing member secured between the first flange and the sliding bearing housing, the biasing member contacting the sliding bearing housing and biasing the link against rotation about a center axis for the rod of the link.
FILED Thursday, March 19, 2020
APPL NO 16/823643
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Jet-propulsion Plants
F02K 1/06 (20130101) Original (OR) Class
F02K 1/1207 (20130101)
F02K 3/075 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248893 Rastegar
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Armament Research, Development and Engineering Center (ARDEC)
United States Army (USA)
APPLICANT(S) Omnitek Partners LLC (Ronkonkoma, New York)
ASSIGNEE(S) OMNITEK PARTNERS LLC (Ronkonkoma, New York)
INVENTOR(S) Jahangir S Rastegar (Stony Brook, New York)
ABSTRACT A device responsive to an acceleration pulse event, the device including: a piezoelectric device configured to generate a voltage over a duration responsive to one or more acceleration pulse events; an electrical storage device configured to receive a portion of the generated voltage to accumulate a charge; an energy dissipating device coupled to the electrical storage device and configured to dissipate the accumulated charge following the one or more acceleration pulse events and not to substantially dissipate the accumulated charge during the one or more acceleration pulse events; and a voltage limiting device coupled to the electrical storage device and configured to limit the portion of the generated voltage applied to the electrical storage device to a predetermined limit.
FILED Wednesday, June 06, 2018
APPL NO 16/001909
ART UNIT 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Ammunition Fuzes; Arming or Safety Means Therefor
F42C 11/02 (20130101) Original (OR) Class
F42C 11/008 (20130101)

Electric Machines Not Otherwise Provided for
H02N 2/181 (20130101)
H02N 2/183 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249094 Wanner et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Ina-Beate Wanner (Topanga, California);  Joseph A. Loo (Encino, California)
ABSTRACT A method for detection or monitoring status of traumatic brain injury (TBI) and/or spinal cord injury (SCI) in a subject is provided. In one embodiment, the method comprises contacting a specimen of bodily fluid obtained from the subject with reagents for assaying for a marker of TBI selected from aldolase C (ALDOC) and brain lipid binding protein (BLBP/FABP7), or a trauma-specific break down product (BDP) of ALDOC or BLBP/FABP7. The method further comprises measuring the amount of marker present in the specimen as compared to a control sample, and determining the presence of TBI or SCI when an elevated amount of marker is present in the specimen compared to the control sample. Optionally, the method further comprises measuring the amount of glutamine synthetase (GS), astrocytic phosphoprotein PEA-15 (PEA15), αB-crystallin (CRYAB/HSP27), a trauma-specific proteolytic cleavage product of ALDOC, GS, PEA15, or CRYAB, or any combination of two or more thereof.
FILED Monday, December 16, 2019
APPL NO 16/716095
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Enzymes
C12Y 201/01259 (20150701)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/577 (20130101)
G01N 33/6848 (20130101)
G01N 33/6896 (20130101) Original (OR) Class
G01N 2800/40 (20130101)
G01N 2800/52 (20130101)
G01N 2800/2871 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249105 Lal et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center Pacific (NIWCPACIFIC)
Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S) Amit Lal (Ithaca, New York);  Serhan Mehmet Ardanuc (Ithaca, New York)
ABSTRACT A SAW-based inertial sensor incorporates a curved SAW drive resonator and graphene electrodes to increase the Coriolis force on a pillar array and generate secondary SAW waves that create a strain-induced hyperfine frequency transition in an enclosed alkali atom vapor, in conjunction with an integrated FP resonator to measure very small inertial signals corresponding to 10 μg and 0.01°/hr, representing a dynamic range of 10 orders of magnitude.
FILED Thursday, March 02, 2017
APPL NO 16/081559
ART UNIT 2861 — Printing/Measuring and Testing
CURRENT CPC
Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 19/5698 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/165 (20130101)

Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement
G01P 15/0802 (20130101)
G01P 15/0922 (20130101)
G01P 15/0975 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249148 Lemay
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) QUINC.TECH INC. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Lee Lemay (San Diego, California)
ABSTRACT Aspects of the present disclosure generally pertain to a magnetic field sensor with flex coupling structures. Aspects of the present disclosure are more specifically directed toward Nanoscale Superconducting Quantum Interference Devices (nanoSQUIDs) with very low white flux noise characteristics can be fashioned into very sensitive magnetic field sensors by using external structures to increase the amount of flux that passes through the nanoSQUID aperture. Aspects of the present disclosure are also directed toward a magnetic flux pickup that can be coupled to a SQUID or nanoSQUID and incorporates an input coil made of a superconducting tape, which may be embodied in an electronic device for sensing magnetic fields, or more specifically an application specific electronic device for sensing a sensed property such as for geophysical sensing or biomedical imaging.
FILED Wednesday, September 25, 2019
APPL NO 16/582711
ART UNIT 2858 — Printing/Measuring and Testing
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/245 (20210101)
A61B 5/0522 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/025 (20130101)
G01R 33/0356 (20130101) Original (OR) Class

Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags
G01V 3/08 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 6/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249158 Irvine et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) The Charles Stark Draper Laboratory, Inc. (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) John M. Irvine (Somerville, Massachusetts);  Laura J. Mariano (Somerville, Massachusetts);  Alexander P. Lin (Boston, Massachusetts)
ABSTRACT A method and a system for analysis of raw MRS data, in the form of signal strength versus chemical shift (ppm), from multiple scanners, includes “signal estimation” from each raw data set, followed by cross-scanner “data harmonization” of results. The final resulting MRS signals are consistent from one scanner to another, and are used for analysis by radiologists and other physicians.
FILED Thursday, August 10, 2017
APPL NO 16/324193
ART UNIT 2868 — Printing/Measuring and Testing
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/4625 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249183 Kendra
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Leidos, Inc. (Reston, Virginia)
ASSIGNEE(S) Leidos, Inc. (Reston, Virginia)
INVENTOR(S) John R. Kendra (Arlington, Virginia)
ABSTRACT A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g. AUX and MOV systems) having differing velocity vectors. Referred to as Motion Extended Array Synthesis (MXAS), the resultant imaging system is comprised of the collection of baselines that are created between the two collection systems as a function of time. Because of the unequal velocity vectors, the process yields a continuum of baselines over some range, which constitutes an offset imaging system (OIS) in that the baselines engendered are similar to those for a real aperture of the same size as that swept out by the relative motion, but which are offset by some (potentially very large) distance.
FILED Wednesday, September 30, 2020
APPL NO 17/039602
ART UNIT 2819 — Semiconductors/Memory
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/46 (20130101)
G01S 13/589 (20130101)
G01S 13/904 (20190501)
G01S 13/9023 (20130101) Original (OR) Class
G01S 13/9082 (20190501)
G01S 13/9088 (20190501)
G01S 2013/0254 (20130101)
G01S 2013/468 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249192 Crouch et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California)
ASSIGNEE(S) BLACKMORE SENSORS and ANALYTICS, LLC (Palo Alto, California)
INVENTOR(S) Stephen C. Crouch (Bozeman, Montana);  Randy R. Reibel (Bozeman, Montana);  James Curry (Bozeman, Montana);  Trenton Berg (Manhattan, Montana)
ABSTRACT Techniques for automatic adaptive scanning with a laser scanner include obtaining range measurements at a coarse angular resolution and forming a horizontally sorted range gate subset and a characteristic range. A fine angular resolution is determined automatically based on the characteristic range and a target spatial resolution. If the fine angular resolution is finer than the coarse angular resolution, then a minimum and maximum vertical angle is automatically determined in each horizontal slice extending a bin size from any previous horizontal slice. A set of adaptive minimum and maximum vertical angles is determined automatically by dilating and interpolating the minimum and maximum vertical angles of all the slices to the second horizontal angular resolution. A horizontal start angle, and the set of adaptive minimum and maximum vertical angles are sent to cause the ranging system to obtain measurements at the second angular resolution.
FILED Tuesday, November 21, 2017
APPL NO 16/464648
ART UNIT 3648 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 13/18 (20130101)
G01S 13/343 (20130101)
G01S 13/428 (20130101)
G01S 13/526 (20130101)
G01S 13/582 (20130101)
G01S 17/42 (20130101) Original (OR) Class
G01S 17/89 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249289 Bodkin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Chemical Biological Center (CCDC CBC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Bodkin Design and Engineering LLC (Wellesley, Massachusetts)
ASSIGNEE(S) BODKIN DESIGN AND ENGINEERING LLC (Newton, Massachusetts)
INVENTOR(S) Andrew Bodkin (Dover, Massachusetts);  James T. Daly (Mansfield, Massachusetts)
ABSTRACT A spectral imager includes a filter array, a pixel array, and a lenslet array therebetween. The filter array includes a plurality of filter regions. The lenslet array includes a plurality of lenslets each configured to form a respective image of the filter array on a respective one of a plurality of regions of the pixel array. The spectral imager may also include a fore-optic lens, the filter array being located between the lenslet array and the fore-optic lens. The spectral imager may also include a fore-optic lens, the filter array being located between the lenslet array and the fore-optic lens. Each of the plurality of filter regions is configured to selectively transmit radiation based on wavelength and/or polarization.
FILED Friday, January 24, 2020
APPL NO 16/752615
ART UNIT 2486 — Recording and Compression
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 3/0006 (20130101)
G02B 5/281 (20130101)
G02B 5/284 (20130101)
G02B 13/14 (20130101) Original (OR) Class
G02B 27/288 (20130101)

Pictorial Communication, e.g Television
H04N 5/332 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249720 Sadi et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Office of the Director of National Intelligence (ODNI)
Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) Fazle Sadi (Pittsburgh, Pennsylvania);  Larry Pileggi (Pittsburgh, Pennsylvania);  Franz Franchetti (Pittsburgh, Pennsylvania)
ABSTRACT Disclosed herein is a novel multi-way merge network, referred to herein as a Hybrid Comparison Look Ahead Merge (HCLAM), which incurs significantly less resource consumption as scaled to handle larger problems. In addition, a parallelization scheme is disclosed, referred to herein as Parallelization by Radix Pre-sorter (PRaP), which enables an increase in streaming throughput of the merge network. Furthermore, high performance reduction scheme is disclosed to achieve full throughput.
FILED Tuesday, November 19, 2019
APPL NO 16/688055
ART UNIT 2182 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 7/16 (20130101) Original (OR) Class
G06F 7/49 (20130101)
G06F 7/49942 (20130101)
G06F 9/544 (20130101)
G06F 9/30079 (20130101)
G06F 16/9027 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11250103 Letourneau
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Reservoir Labs, Inc. (New York, New York)
ASSIGNEE(S) Reservoir Labs, Inc. (New York, New York)
INVENTOR(S) Pierre-David Letourneau (Long Island, New York)
ABSTRACT A system for determining the frequency coefficients of a one or multi-dimensional signal that is sparse in the frequency domain includes determining the locations of the non-zero frequency coefficients, and then determining values of the coefficients using the determined locations. If N is total number of frequency coefficients across the one or more dimension of the signal, and if R is an upper bound of the number of non-zero ones of these frequency coefficients, the systems requires up to (O (R log(R) (N))) samples and has a computation complexity of up to O (R log2(R) log (N). The system and the processing technique are stable to low-level noise and can exhibit only a small probability of failure. The frequency coefficients can be real and positive or they can be complex numbers.
FILED Wednesday, January 25, 2017
APPL NO 15/415368
ART UNIT 2182 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 17/142 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11250189 Clark et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) John Clark (Oakwood, Ohio);  Joseph Beck (Minneapolis, Minnesota)
ABSTRACT Identifying effects of geometric variations of physical parts may include measuring one or more surfaces of a physical part in three-dimensions, analyzing measurements of the physical part to determine a geometric variation from a baseline model, modifying an existing computational fluid dynamics (CFD) mesh for the baseline model based on the geometric variation using a mesh metamorphosis algorithm to create a target mesh for the physical part, and analyzing the target mesh using a CFD analysis to determine an effect (e.g., an effect on unsteadiness) in a system caused by the geometric variation.
FILED Wednesday, March 13, 2019
APPL NO 16/351799
ART UNIT 2148 — Computer Architecture and I/O
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/16 (20130101)
F01D 5/26 (20130101)
F01D 25/06 (20130101)

Springs; Shock-absorbers; Means for Damping Vibration
F16F 15/005 (20130101)

Electric Digital Data Processing
G06F 30/23 (20200101) Original (OR) Class
G06F 30/28 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251330 Grandusky et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
United States Army (USA)
APPLICANT(S) James R. Grandusky (Waterford, New York);  Leo J. Schowalter (Latham, New York);  Muhammad Jamil (Watervliet, New York);  Mark C. Mendrick (Albany, New York);  Shawn R. Gibb (Clifton Park, New York)
ASSIGNEE(S) CRYSTAL IS, INC. (Green Island, New York)
INVENTOR(S) James R. Grandusky (Waterford, New York);  Leo J. Schowalter (Latham, New York);  Muhammad Jamil (Watervliet, New York);  Mark C. Mendrick (Albany, New York);  Shawn R. Gibb (Clifton Park, New York)
ABSTRACT In various embodiments, light-emitting devices incorporate smooth contact layers and polarization doping (i.e., underlying layers substantially free of dopant impurities) and exhibit high photon extraction efficiencies.
FILED Friday, March 03, 2017
APPL NO 15/449044
ART UNIT 2819 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 33/04 (20130101)
H01L 33/06 (20130101)
H01L 33/12 (20130101)
H01L 33/14 (20130101)
H01L 33/22 (20130101)
H01L 33/32 (20130101)
H01L 33/40 (20130101)
H01L 33/42 (20130101)
H01L 33/46 (20130101)
H01L 33/60 (20130101)
H01L 33/0075 (20130101) Original (OR) Class
H01L 33/325 (20130101)
H01L 33/387 (20130101)
H01L 33/405 (20130101)
H01L 2933/0016 (20130101)
H01L 2933/0025 (20130101)
H01L 2933/0058 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251385 Ellingson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The University of Toledo (Toledo, Ohio)
ASSIGNEE(S) The University of Toledo (Toledo, Ohio)
INVENTOR(S) Randall J. Ellingson (Toledo, Ohio);  Khagendra P. Bhandari (Toledo, Ohio);  Michael Heben (Toledo, Ohio);  Suneth Watthage (Toledo, Ohio);  Zhaoning Song (Toledo, Ohio)
ABSTRACT Hole transport layers, electron transport layers, layer stacks, and optoelectronic devices involving perovskite materials and materials used as precursors, and methods of making the same, are described.
FILED Friday, January 26, 2018
APPL NO 15/880807
ART UNIT 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/302 (20130101)
H01L 51/0077 (20130101)
H01L 51/424 (20130101)
H01L 51/441 (20130101)
H01L 51/4213 (20130101) Original (OR) Class
H01L 2031/0344 (20130101)
H01L 2251/301 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/549 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251475 Hopkins et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
United States Air Force (USAF)
Under Secretary of Defense for Research and Engineering (USDR&E)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Brandon James Hopkins (Cambridge, Massachusetts);  Douglas P. Hart (Charlestown, Massachusetts)
ABSTRACT Corrosion mitigation in a metal-air battery includes displacing an electrolyte within a gap of the metal-air battery with a liquid. The liquid may be substantially nonreactive with the electrolyte, and the anode of the metal-air battery is less reactive with the liquid than with the electrolyte. Upon displacement of the electrolyte from the gap, the liquid may remain in the gap of the metal-air battery to reduce the likelihood of corrosion of the anode and, therefore, reduce the power drain of the battery resulting from such corrosion. To return the metal-air battery to an activated state for generating power, the electrolyte may be moved back into the gap to displace the liquid. A fluid circuit may be in fluid communication with the gap and may displace one of the liquid and the electrolyte in the gap with the other one of the liquid and the electrolyte from the fluid circuit.
FILED Wednesday, March 01, 2017
APPL NO 16/091897
ART UNIT 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/463 (20130101)
H01M 10/46 (20130101)
H01M 10/052 (20130101)
H01M 10/0525 (20130101)
H01M 12/02 (20130101) Original (OR) Class
H01M 12/06 (20130101)
H01M 12/08 (20130101)
H01M 50/77 (20210101)
H01M 2220/20 (20130101)
H01M 2250/20 (20130101)
H01M 2300/0014 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/10 (20130101)

Climate Change Mitigation Technologies Related to Transportation
Y02T 10/70 (20130101)
Y02T 90/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252178 Malveaux et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Metis Technology Solutions, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S) METIS TECHNOLOGY SOLUTIONS, INC. (Albuquerque, New Mexico)
INVENTOR(S) Chloe Malveaux (Albuquerque, New Mexico);  Julie Christenson (Albuquerque, New Mexico)
ABSTRACT A system and method for determining a point in time compliance status of a computing system with a security guideline standard (SGS) wherein the computing system has a command line shell available through a native operating system, the method comprising inputting into a host computer of the computing system a SGS package that represents a scripted SGS that is a non-text file and is encrypted that provides instructions for an evaluation of a computing system's compliance with the SGS under consideration wherein the SGS package performs at least a portion of an automated evaluation of a compliance status at the point in time of the computing system under consideration when the SGS package is decrypted by the computing system; sending a command query from the decrypted SGS package to the selected device of the computer system; compiling in a locally hosted database of the host computer compliance results sent from the selected device of the computing system in response to the command query from the decrypted SGS package that is applicable for the selected device; and generating a report for the compliance results of the selected device with the SGS package that is applicable.
FILED Thursday, July 23, 2020
APPL NO 16/937391
ART UNIT 2434 — Cryptography and Security
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/20 (20130101)
H04L 63/105 (20130101)
H04L 63/1433 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252351 Kelly et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
U.S. Air Force
Under Secretary of Defense for Research and Engineering (USDR&E)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Michael W. Kelly (North Reading, Massachusetts);  Megan H. Blackwell (Winchester, Massachusetts);  Curtis Colonero (Shrewsbury, Massachusetts);  James Wey (Arlington, Massachusetts);  Christopher David (Chelmsford, Massachusetts);  Justin Baker (North Andover, Massachusetts);  Joseph Costa (Bedford, Massachusetts)
ABSTRACT When imaging bright objects, a conventional detector array can saturate, making it difficult to produce an image with a dynamic range that equals the scene's dynamic range. Conversely, a digital focal plane array (DFPA) with one or more m-bit counters can produce an image whose dynamic range is greater than the native dynamic range. In one example, the DFPA acquires a first image over a relatively brief integration period at a relatively low gain setting. The DFPA then acquires a second image over longer integration period and/or a higher gain setting. During this second integration period, counters may roll over, possibly several times, to capture a residue modulus 2m of the number of counts (as opposed to the actual number of counts). A processor in or coupled to the DFPA generates a high-dynamic range image based on the first image and the residues modulus 2m.
FILED Wednesday, June 10, 2020
APPL NO 16/897339
ART UNIT 2698 — Selective Visual Display Systems
CURRENT CPC
Pictorial Communication, e.g Television
H04N 5/355 (20130101)
H04N 5/2355 (20130101)
H04N 5/23254 (20130101)
H04N 5/23267 (20130101)
H04N 5/35572 (20130101)
H04N 5/35581 (20130101) Original (OR) Class
H04N 5/37455 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252512 Zhou et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California at Berkeley, CA (UC BERKELEY)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Qin Zhou (Fremont, California);  Alexander K. Zettl (Kensington, California)
ABSTRACT This disclosure provides systems, methods, and device associated with an electrostatically driven graphene speaker. In one aspect, the device includes a graphene membrane having a diameter of about 3 millimeters to about 11 millimeters, and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device is a microphone or a loudspeaker.
FILED Friday, August 14, 2020
APPL NO 16/993882
ART UNIT 2651 — Videophones and Telephonic Communications
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 15/00 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 19/02 (20130101)
H04R 19/005 (20130101) Original (OR) Class
H04R 23/002 (20130101)
H04R 29/001 (20130101)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/733 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 11246543 Tai et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) WASHINGTON UNIVERSITY (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Yuan-Chuan Tai (St. Louis, Missouri);  Jie Wen (St. Louis, Missouri);  Ke Li (St. Louis, Missouri);  Aswin John Mathews (St. Louis, Missouri)
ABSTRACT A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector panel, a tracking system configured to detect a position of said second detector panel relative to the first detector panel while imaging a subject, a computing device in communication with the first detector panel, the second detector panel, and the tracking system, the computing device configured to receive coincidence data from the first and second detector panels, receive position data from the tracking system, wherein each coincidence datum of the received coincidence data is associated with a unique position datum of the received position data, and reconstruct a plurality of images based on the received coincidence data and the received position data.
FILED Thursday, November 12, 2015
APPL NO 15/524699
ART UNIT 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 6/025 (20130101)
A61B 6/037 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/2985 (20130101)

Image Data Processing or Generation, in General
G06T 11/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246920 Haynes et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Security, LLC (LANS)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC at Los Alamos, NM (TRIAD)
APPLICANT(S) Duke University (Durham, North Carolina);  Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S) Duke University (Durham, North Carolina);  Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S) Barton F. Haynes (Durham, North Carolina);  Mattia Bonsignori (Durham, North Carolina);  Bette T. Korber (Los Alamos, New Mexico);  Peter T. Hraber (Los Alamos, New Mexico);  Kevin Saunders (Durham, North Carolina)
ABSTRACT In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.
FILED Friday, March 03, 2017
APPL NO 16/081771
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 2039/55555 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2740/16122 (20130101)
C12N 2740/16134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247191 Janke et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC at Oak Ridge, TN (UTB)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Christopher J. Janke (Oliver Springs, Tennessee);  Richard T. Mayes (Knoxville, Tennessee);  Sadananda Das (Kissimmee, Florida);  Sheng Dai (Knoxville, Tennessee)
ABSTRACT A method of producing a functionalized material that extracts metal ions from solution, the method comprising: (i) providing a precursor material having nitrile groups appended to its surface; and (ii) reacting said nitrile groups with hydroxylamine or a derivative thereof in the presence of a polar aprotic solvent at a temperature of 60-80° C. for at least 1 hour, to convert at least a portion of said nitrile groups to amidoxime and imide dioxime groups, followed by reaction with a base capable of hydrolyzing any remaining nitrile groups to carboxylic acid groups; wherein said functionalized material has a higher uranium absorption capacity than a functionalized material produced under same conditions except that the nitrile groups are reacted with hydroxylamine in only a protic solvent. The invention is also directed to functionalized materials produced by the above-described method, and methods for using the functionalized material for extracting metal ions from metal-containing solutions.
FILED Monday, June 08, 2020
APPL NO 16/895609
ART UNIT 1762 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/265 (20130101) Original (OR) Class
B01J 20/321 (20130101)
B01J 20/3085 (20130101)
B01J 20/3217 (20130101)
B01J 20/3265 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/285 (20130101)
C02F 2101/006 (20130101)
C02F 2101/20 (20130101)
C02F 2103/08 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 255/02 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/247 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 6/46 (20130101)

Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials
D06M 10/008 (20130101)
D06M 11/38 (20130101)
D06M 13/368 (20130101)
D06M 14/10 (20130101)
D06M 14/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247295 Bol'shakov et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Applied Spectra, Inc. (, None)
ASSIGNEE(S) Applied Spectra, Inc. (West Sacramento, California)
INVENTOR(S) Alexander A. Bol'shakov (Union City, California);  Chunyi Liu (Fremont, California);  Sudeep J. Pandey (Sacramento, California);  Richard E. Russo (Walnut Creek, California)
ABSTRACT Methods of liquid and solid materials analysis by laser induced ablation spectroscopy are disclosed. The liquid and solid materials are analyzed in an instrument having one pulsed laser to produce emissive plasma plumes and ablate solid material. Liquid phase samples are aerosolized before streaming to an analysis zone where they are dissociated into a plasma plume. A large number of sites within solid phase sample structures and be analyzed using a movable x-y-z stage and displayed in a chemical map.
FILED Friday, October 16, 2020
APPL NO 17/073292
ART UNIT 2877 — Optics
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/048 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/718 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247896 Michalska et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC at Argonne, IL (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UChicago Argonne, LLC (Chicago, Illinois)
INVENTOR(S) Martyna Michalska (Chicago, Illinois);  Philip D. Laible (Downers Grove, Illinois);  Ralu Divan (Darien, Illinois)
ABSTRACT A material with a nanotexture comprising structures extending from a substrate. The structures are modified by coating the nanotexture with a protective coating and partially removing the coating, exposing a portion of the structure for functionalization.
FILED Tuesday, July 30, 2019
APPL NO 16/526964
ART UNIT 1713 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 37/0015 (20130101)
A61M 2037/0023 (20130101)
A61M 2037/0053 (20130101)

Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 1/008 (20130101)
B81B 2201/055 (20130101)

Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems
B81C 1/00111 (20130101) Original (OR) Class
B81C 1/00388 (20130101)
B81C 2201/0157 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/38 (20130101)
G03F 7/265 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247956 Krishna et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Siddarth H. Krishna (Madison, Wisconsin);  George W. Huber (Middleton, Wisconsin);  James A. Dumesic (Verona, Wisconsin)
ABSTRACT A method of making of 1,2,5,6-hexanetetrol (“tetrol”). The method includes the steps of contacting a reaction solution containing water as well as levoglucosenone, dihydrolevoglucosenone, and/or levoglucosanol, with a catalyst containing metal and acid functionalities, at temperature of from about 100° C. to about 175° C., and a hydrogen partial pressure of from about 1 bar to about 50 bar (about 0.1 MPa to about 5 MPa), and for a time wherein at least a portion of the reactant is converted into 1,2,5,6-hexanetetrol.
FILED Friday, April 19, 2019
APPL NO 17/049241
ART UNIT 1622 — Organic Chemistry
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/12 (20130101)
B01J 23/42 (20130101)
B01J 23/44 (20130101)
B01J 23/462 (20130101)
B01J 23/464 (20130101)

Acyclic or Carbocyclic Compounds
C07C 29/132 (20130101)
C07C 29/132 (20130101)
C07C 29/172 (20130101)
C07C 29/172 (20130101)
C07C 29/175 (20130101) Original (OR) Class
C07C 29/175 (20130101)
C07C 31/24 (20130101)
C07C 31/24 (20130101)
C07C 31/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248121 Naskar et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC at Oak Ridge, TN (UTB)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Amit K. Naskar (Knoxville, Tennessee);  Ngoc A. Nguyen (Oak Ridge, Tennessee)
ABSTRACT A solid polymer blend material comprising: (i) lignin; and (ii) a polyamide having a melting point of no more than 240° C. and which is below the decomposition temperature of the lignin; wherein said lignin is homogeneously dispersed in said polyamide. Methods for producing the blend material are also described. Methods for producing objects made of the blend material by melt extrusion are also described, comprising: (a) melt blending components (i) and (ii) to form a polymer blend in which components (i) and (ii) are homogeneously blended, wherein the polymer blend exhibits a melt viscosity of no more than 2000 Pa·s at a shear rate of 100-1000 s−1 and when heated to a temperature of no more than 240° C.; and; (b) forming an object made of said polymer blend material.
FILED Friday, January 25, 2019
APPL NO 16/257294
ART UNIT 1767 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2093/00 (20130101)
B29K 2277/00 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 69/08 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/046 (20170501)
C08K 3/046 (20170501)
C08K 7/06 (20130101)

Compositions of Macromolecular Compounds
C08L 77/00 (20130101)
C08L 77/02 (20130101)
C08L 77/02 (20130101)
C08L 77/02 (20130101)
C08L 77/02 (20130101)
C08L 77/06 (20130101)
C08L 77/06 (20130101)
C08L 97/005 (20130101) Original (OR) Class
C08L 97/005 (20130101)
C08L 97/005 (20130101)
C08L 97/005 (20130101)
C08L 97/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248215 Dietrich et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Lygos, Inc. (Berkeley, California)
ASSIGNEE(S) Lygos, Inc. (Berkeley, California)
INVENTOR(S) Jeffrey A. Dietrich (Berkeley, California);  Jeffrey L. Fortman (Berkeley, California);  Eric J. Steen (Berkeley, California)
ABSTRACT Systems and methods for the production of malonate in recombinant host cells.
FILED Monday, October 07, 2019
APPL NO 16/595253
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 51/38 (20130101)
C07C 67/08 (20130101)
C07C 67/31 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/16 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/46 (20130101)

Enzymes
C12Y 301/02004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248303 Liu
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Molecule Works Inc. (Richland, Washington)
ASSIGNEE(S) Molecule Works Inc. (Richland, Washington)
INVENTOR(S) Wei Liu (Richland, Washington)
ABSTRACT Electrochemical device using thin micro-porous metal sheets. The porous metal sheet may have a thickness less than 200 μm, provides three-dimensional networked pore structures of pore sizes in the range of 2.0 nm to 5.0 μm, and is electrically conductive. The micro-porous metal sheet is used for positively and/or negatively-charged electrodes by providing large specific contact surface area of reactants/electron. Nano-sized catalyst or features can be added inside pores of the porous metal sheet of pore sizes at sub- and micrometer scale to enhance the reaction activity and capacity. Micro-porous ceramic materials may be coated on the porous metal sheet at a thickness of less than 40 μm to enhance the functionality of the porous metal sheet and may function as a membrane separator. The electrochemical device may be used for decomposing molecules and for synthesis of molecules such as synthesis of ammonia from water and nitrogen molecules.
FILED Tuesday, April 30, 2019
APPL NO 16/398468
ART UNIT 1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/00 (20130101)
C25B 1/04 (20130101)
C25B 9/73 (20210101)
C25B 11/031 (20210101) Original (OR) Class
C25B 11/051 (20210101)
C25B 11/057 (20210101)
C25B 11/075 (20210101)
C25B 13/02 (20130101)
C25B 13/04 (20130101)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 9/02 (20130101)
H01G 9/042 (20130101)
H01G 9/052 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/90 (20130101)
H01M 4/8621 (20130101)
H01M 4/8657 (20130101)
H01M 4/9041 (20130101)
H01M 8/0236 (20130101)
H01M 8/1004 (20130101)
H01M 50/46 (20210101)
H01M 50/431 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248705 Sarawate et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FE)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Schenectady, New York)
INVENTOR(S) Neelesh Nandkumar Sarawate (Niskayuna, New York);  Christopher Walter Falcone (Schenectady, New York)
ABSTRACT A flexible seal is used to seal between two adjacent gas turbine components. The flexible seal includes at least one metal ply having a forward end, an aft end axially separated from the forward end, and an intermediate portion between the forward end and the aft end. The intermediate portion defines a continuous curve in the circumferential direction, such that the aft end is circumferentially, and optionally radially, offset from the forward end. A plurality of relief cuts is defined through the at least one metal ply between the forward end and the aft end to increase flexibility and improve sealing in seal slots that are radially offset from one another.
FILED Thursday, January 24, 2019
APPL NO 16/256322
ART UNIT 3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 9/023 (20130101)
F01D 11/003 (20130101)

Pistons; Cylinders; Sealings
F16J 15/0887 (20130101) Original (OR) Class

Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/02 (20130101)
F23R 2900/00012 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248794 Berry
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FE)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Schenectady, New York)
INVENTOR(S) Jonathan Dwight Berry (Simpsonville, South Carolina)
ABSTRACT A fluid mixing apparatus includes mixing conduits that extend through a fluid plenum. The fluid plenum, which surrounds a first wall defining a main passage fluidly coupled to a low-pressure fluid source, is surrounded itself by a second wall defining a high-pressure plenum fluidly coupled to a high-pressure fluid source. An insulated tube disposed at the inlet of the first wall delivers a third fluid. The mixing conduits fluidly couple the high-pressure plenum to the main passage, where the high-pressure fluid is mixed with low-pressure fluid and the third fluid. Optionally, the fluid plenum may house a fourth fluid that is injected through injection holes in the mixing conduits. The fluid mixing apparatus may be used to mix one or more fuels with high- and low-pressure air in a gas turbine combustor. Alternately, the fluid mixing apparatus may mix a fluid with high- and low-pressure water streams.
FILED Tuesday, December 31, 2019
APPL NO 16/731306
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 3/30 (20130101)
F02C 7/22 (20130101)

Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/34 (20130101)
F23R 3/36 (20130101)
F23R 3/50 (20130101)
F23R 3/286 (20130101) Original (OR) Class
F23R 3/346 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249046 Pan et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
ASSIGNEE(S) The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama)
INVENTOR(S) Shanlin Pan (Tuscaloosa, Alabama);  Caleb M. Hill (Northport, Alabama)
ABSTRACT Provided herein are systems and methods for the detection, quantification, and/or monitoring of analytes in samples. The systems and methods can be used, for example, to track the deposition and electrochemical behavior of individual nanoparticles and nanoparticles clusters clusters in situ with high spatial and temporal resolution. The systems and methods can be used to track the deposition and oxidation of several hundreds to thousands of nanoparticles simultaneously and reconstruct their voltammetric curves at the single nanoparticle level.
FILED Thursday, November 07, 2019
APPL NO 16/676603
ART UNIT 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/03 (20130101)
G01N 27/42 (20130101) Original (OR) Class
G01N 27/305 (20130101)
G01N 2021/6482 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249765 Gutierrez
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC at Livermore, CA (LLNS)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S) Advanced Micro Devices, Inc. (Santa Clara, California)
INVENTOR(S) Anthony T. Gutierrez (Bellevue, Washington)
ABSTRACT Techniques for improving performance of accelerated processing devices (“APDs”) when exceptions occur are provided. In APDs, the very large number of parallel processing execution units, and the complexity of the hardware used to execute a large number of work-items in parallel, means that APDs typically stall when an exception occurs (unlike in central processing units (“CPUs”), which are able to execute speculatively and out-of-order). However, the techniques provided herein allow at least some execution to occur past exceptions. Execution past an exception generating instruction occurs by executing instructions that would not lead to a corruption while skipping those that would lead to a corruption. After the exception has been satisfied, execution occurs in a replay mode in which the potentially exception-generating instruction is executed and in which instructions that did not execute in the exception-wait mode are executed. A mask and counter are used to control execution in replay mode.
FILED Wednesday, August 22, 2018
APPL NO 16/109567
ART UNIT 2183 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 9/3865 (20130101) Original (OR) Class
G06F 9/30018 (20130101)

Image Data Processing or Generation, in General
G06T 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249918 Walker et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC at Livermore, CA (LLNS)
APPLICANT(S) Hewlett Packard Enterprise Development LP (Houston, Texas)
ASSIGNEE(S) Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S) Shawn K. Walker (Fort Collins, Colorado);  Christopher Shawn Kroeger (Longmont, Colorado);  Derek A. Sherlock (Fort Collins, Colorado)
ABSTRACT A memory access system may include a first memory address translator, a second memory address translator and a mapping entry invalidator. The first memory address translator translates a first virtual address in a first protocol of a memory access request to a second virtual address in a second protocol and tracks memory access request completions. The second memory address translator is to translate the second virtual address to a physical address of a memory. The mapping entry invalidator requests invalidation of a first mapping entry of the first mapping address translator requests invalidation of a second mapping entry of the second memory address translator corresponding to the first mapping entry following invalidation of the first mapping entry and based upon the tracked memory access request completions.
FILED Tuesday, October 30, 2018
APPL NO 16/174738
ART UNIT 2181 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 12/1009 (20130101) Original (OR) Class
G06F 13/16 (20130101)
G06F 13/4282 (20130101)
G06F 2212/657 (20130101)
G06F 2213/0026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11250587 Zhu et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC at Golden, CO (ASE)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S) Guangdong Zhu (Englewood, Colorado);  Rebecca Amelia Mitchell (Boulder, Colorado)
ABSTRACT The present disclosure describes non-intrusive optical (NIO) characterization methods which efficiency measures optical errors (such as mirror surface slope error, mirror canting error, and heliostat tracking error) of a heliostat field. The methods utilize photogrammetry and deflectometry to analyze an image taken of a heliostat to determine optical errors and increase the amount of solar energy delivered by the heliostat to the receiver.
FILED Monday, September 28, 2020
APPL NO 17/034660
ART UNIT 2486 — Recording and Compression
CURRENT CPC
Systems for Controlling or Regulating Non-electric Variables
G05D 3/105 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/4671 (20130101)
G06K 9/6268 (20130101)

Image Data Processing or Generation, in General
G06T 7/60 (20130101)
G06T 7/73 (20170101) Original (OR) Class
G06T 2207/10032 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11250980 McIntyre
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC at Oak Ridge, TN (UTB)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Timothy J. McIntyre (Oak Ridge, Tennessee)
ABSTRACT A system and a method for separating and recycling magnets made from rare earth elements from an article of manufacture used an alignment device to property position the rare earth magnet for processing. Once proper alignment is made, a separating device removes the magnet and a portion of the article. A heating device demagnetizes the magnets and vibration causes the magnets to separate from the portion of the article. Electromagnets remove the portion of the article and the rare earth magnets pass through for reclamation.
FILED Thursday, March 26, 2020
APPL NO 16/830932
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields
B03C 1/26 (20130101)
B03C 1/0335 (20130101)

Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/40 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 13/006 (20130101) Original (OR) Class

Electric Heating; Electric Lighting Not Otherwise Provided for
H05B 6/103 (20130101)
H05B 2206/023 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 10/20 (20151101)

Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management
Y02W 30/50 (20150501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251318 Oh et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC at Golden, CO (ASE)
APPLICANT(S) Jihun Oh (Golden, Colorado);  Howard M. Branz (Golden, Colorado);  Hao-Chih Yuan (Conifer, Colorado)
ASSIGNEE(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S) Jihun Oh (Golden, Colorado);  Howard M. Branz (Golden, Colorado);  Hao-Chih Yuan (Conifer, Colorado)
ABSTRACT A photovoltaic (PV) device with improved blue response. The PV device includes a silicon substrate with an emitter layer on a light receiving side. The emitter layer has a low opant level such that it has sheet resistance of 90 to 170 ohm/sq. Anti-reflection in the PV device is provided solely by a nano-structured or black silicon surface on the light-receiving surface, through which the emitter is formed by diffusion. The nano structures of the black silicon are formed in a manner that does not result in gold or another high-recombination metal being left in the black silicon such as with metal-assisted etching using silver. The black silicon is further processed to widen these pores so as to provide larger nanostructures with lateral dimensions in the range of 65 to 150 nanometers so as to reduce surface area and also to etch away a highly doped portion of the emitter.
FILED Tuesday, March 08, 2011
APPL NO 14/002950
ART UNIT 1759 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/0284 (20130101)
H01L 31/1868 (20130101)
H01L 31/02168 (20130101) Original (OR) Class
H01L 31/02363 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/50 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 70/50 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251386 Che et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Office of Science (DOE-SC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S) The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S) Xiaozhou Che (Ann Arbor, Michigan);  Xin Xiao (Ann Arbor, Michigan);  Stephen R. Forrest (Ann Arbor, Michigan)
ABSTRACT A highly efficient multi junction photovoltaic device, such as a two, three, or four junction device, is disclosed. The multi-junction device may include a first subcell comprising a first photoactive region and a second subcell comprising a second photoactive region. The first and second photoactive regions are designed to minimize spectral overlap and maximize photocurrent across a broad absorption spectra, such as wavelengths ranging from 400 nm to 900 nm. The device may further include an inter-connecting layer, disposed between the first subcell and the second subcell, that is at least substantially transparent. By introducing a transparent interconnecting layer, a dual element (tandem) cell achieves a power conversion efficiency of 10.0±0.5%. By adding an additional (3rd) sub-cell that absorbs at the second order optical interference maximum within the stack. The triple junction cell significantly improves the quantum efficiency at shorter wavelengths, achieving a power conversion efficiency of 11.1±0.5%. Adding additional sub-cells has been shown to increase power conversion efficiency above 12%.
FILED Monday, April 06, 2015
APPL NO 15/125690
ART UNIT 1721 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0046 (20130101)
H01L 51/0054 (20130101)
H01L 51/0056 (20130101)
H01L 51/0059 (20130101)
H01L 51/0068 (20130101)
H01L 51/0069 (20130101)
H01L 51/0072 (20130101)
H01L 51/422 (20130101)
H01L 51/4246 (20130101) Original (OR) Class

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/549 (20130101)

Climate Change Mitigation Technologies in the Production or Processing of Goods
Y02P 70/50 (20151101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251430 Siu et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The Research Foundation for the State University of New York (Binghamton, New York)
ASSIGNEE(S) The Research Foundation for The State University of New York (Binghamton, New York)
INVENTOR(S) Carrie Siu (Philadelphia, Pennsylvania);  M. Stanley Whittingham (Vestal, New York)
ABSTRACT The epsilon polymorph of vanadyl phosphate, ε-VOPO4, made from the solvothermally synthesized H2VOPO4, is a high density cathode material for lithium-ion batteries optimized to reversibly intercalate two Li-ions to reach the full theoretical capacity at least 50 cycles with a coulombic efficiency of 98%. This material adopts a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V.
FILED Monday, March 04, 2019
APPL NO 16/291617
ART UNIT 1722 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 25/372 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/72 (20130101)
C01P 2002/90 (20130101)
C01P 2004/03 (20130101)
C01P 2004/04 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/136 (20130101)
H01M 4/623 (20130101)
H01M 4/625 (20130101)
H01M 4/1397 (20130101)
H01M 4/5825 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/021 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251433 Dai et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC at Oak Ridge, TN (UTB)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Sheng Dai (Knoxville, Tennessee);  Xiao-Guang Sun (Knoxville, Tennessee);  Xiqing Wang (Mason, Ohio);  Richard T. Mayes (Knoxville, Tennessee)
ABSTRACT The invention is directed in a first aspect to electron-conducting porous compositions comprising an organic polymer matrix doped with nitrogen atoms and having elemental sulfur dispersed therein, particularly such compositions having an ordered framework structure. The invention is also directed to composites of such S/N-doped electron-conducting porous aromatic framework (PAF) compositions, or composites of an S/N-doped mesoporous carbon composition, which includes the S/N-doped composition in admixture with a binder, and optionally, conductive carbon. The invention is further directed to cathodes for a lithium-sulfur battery in which such composites are incorporated.
FILED Friday, June 29, 2018
APPL NO 16/023563
ART UNIT 1766 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/136 (20130101)
H01M 4/137 (20130101)
H01M 4/364 (20130101)
H01M 4/583 (20130101)
H01M 4/602 (20130101) Original (OR) Class
H01M 4/606 (20130101)
H01M 4/623 (20130101)
H01M 4/625 (20130101)
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251453 Edmundson et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) W. L. Gore and Associates, Inc. (Newark, Delaware)
ASSIGNEE(S) W. L. Gore and Associates, Inc. (Newark, Delaware)
INVENTOR(S) Mark Edmundson (Philadelphia, Pennsylvania);  F. Colin Busby (Newark, Delaware)
ABSTRACT Methods and compositions for making fuel cell components are described. In one embodiment, the method comprises providing a substrate, and forming or adhering an electrode on the substrate, wherein the forming includes depositing an aqueous mixture comprising water, a water-insoluble component, a catalyst, and an ionomer. The water-insoluble component comprises a water-insoluble alcohol, a water-insoluble carboxylic acid, or a combination thereof. The use of such water-insoluble components results in a stable liquid medium with reduced reticulation upon drying, reduced dissolution of the substrate, and reduced penetration of the pores of the substrate.
FILED Friday, December 22, 2017
APPL NO 16/092440
ART UNIT 1759 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/8807 (20130101)
H01M 4/9083 (20130101)
H01M 8/1004 (20130101) Original (OR) Class
H01M 2008/1095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251717 Barlow et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
Small Business Technology Transfer (STTR)
APPLICANT(S) Matthew Barlow (Springdale, Arkansas);  James A. Holmes (Fayetteville, Arkansas)
ASSIGNEE(S)
INVENTOR(S) Matthew Barlow (Springdale, Arkansas);  James A. Holmes (Fayetteville, Arkansas)
ABSTRACT An integrated silicon carbide rectifier circuit with an on chip isolation diode. The isolation diode can be a channel-to-substrate isolation diode or a channel to channel isolation diode. the circuit teaches an integrated diode rectification circuit for use with a two phase center tap transformer having a first voltage output, a second voltage output, and a center tap output with a single chip having a first half-wave rectifier connected to the first voltage output, a second half-wave rectifier connected to the second voltage output, and a floating substrate connection connected to the center tap output and an on chip first channel-to-substrate isolation diode electrically connected between the first half-wave rectifier and the floating substrate.
FILED Friday, June 12, 2020
APPL NO 16/899941
ART UNIT 2838 — Electrical Circuits and Systems
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/808 (20130101)

Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof
H02M 7/06 (20130101)
H02M 7/219 (20130101)
H02M 7/2176 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251889 Derr et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC at Idaho Falls, ID (BEA)
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho);  University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho);  University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S) Kurt W. Derr (Idaho Falls, Idaho);  Samuel Ramirez (Shelley, Idaho);  Sneha K. Kasera (Salt Lake City, Utah);  Christopher D. Becker (Aitkin, Minnesota);  Aniqua Z. Baset (Salt Lake City, Utah)
ABSTRACT Wireless signal classifiers and systems that incorporate the same may include an energy-based detector configured to analyze an entire set of measurements and generate a first signal classification result, a cyclostationary-based detector configured to analyze less than the entire set of measurements and generate a second signal classification result; and a classification merger configured to merge the first signal classification result and the second signal classification result. Ensemble wireless signal classification and systems and devices the incorporate the same are disclosed. Some ensemble wireless signal classification may include energy-based classification processes and machine learning-based classification processes. In some embodiments, incremental machine learning techniques may be incorporated to add new machine learning-based classifiers to a system or update existing machine learning-based classifiers.
FILED Thursday, September 12, 2019
APPL NO 16/569565
ART UNIT 2645 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 20/10 (20190101)

Transmission
H04B 17/345 (20150115) Original (OR) Class
H04B 17/391 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252241 Krishna Dhulipala et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Rama Vamshi Krishna Dhulipala (Clarksburg, Maryland);  Koushik Kashojjula (Germantown, Maryland);  Timothy Clark Winter (Frederick, Maryland)
ASSIGNEE(S)
INVENTOR(S) Rama Vamshi Krishna Dhulipala (Clarksburg, Maryland);  Koushik Kashojjula (Germantown, Maryland);  Timothy Clark Winter (Frederick, Maryland)
ABSTRACT The present invention provides a system and method for enabling a plurality of IoT applications running on a gateway to utilize a sub-set of underlying protocol services in a common way, where each application is agnostic of the specific implementation of each protocol service and has the flexibility to use any of the underlying protocols in the service set without impacting or restricting the application or any other applications that are sharing the protocol service set.
FILED Friday, October 09, 2020
APPL NO 17/067114
ART UNIT 2446 — Computer Networks
CURRENT CPC
Information and Communication Technology Specially Adapted for the Internet of Things [IOT]
G16Y 10/75 (20200101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/0806 (20130101)
H04L 67/16 (20130101)
H04L 67/32 (20130101)
H04L 67/141 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252339 Bammes et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Direct Electron, LP (San Diego, California)
ASSIGNEE(S) Direct Electron, LP (San Diego, California)
INVENTOR(S) Benjamin Bammes (Pearland, Texas);  Robert Bilhorn (San Diego, California)
ABSTRACT The present disclosure relates to an apparatus and methods for generating a hybrid image by high-dynamic-range counting. In an embodiment, the apparatus includes a processing circuitry configured to acquire an image from a pixelated detector, obtain a sparsity map of the acquired image, the sparsity map indicating low-flux regions of the acquired image and high-flux regions of the acquired image, generate a low-flux image and a high-flux image based on the sparsity map, perform event analysis of the acquired image based on the low-flux image and the high-flux image, the event analysis including detecting, within the low-flux image, incident events by an event counting mode, multiply, by a normalization constant, resulting intensities of the high-flux image and the detected incident events of the low-flux image, and generate the hybrid image by merging the low-flux image and the high-flux image.
FILED Friday, April 17, 2020
APPL NO 16/851931
ART UNIT 2696 — Selective Visual Display Systems
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 37/28 (20130101)
H01J 2237/2806 (20130101)
H01J 2237/2817 (20130101)
H01J 2237/24592 (20130101)

Pictorial Communication, e.g Television
H04N 5/00 (20130101)
H04N 5/341 (20130101)
H04N 5/2355 (20130101) Original (OR) Class
H04N 5/3655 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252512 Zhou et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California at Berkeley, CA (UC BERKELEY)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Qin Zhou (Fremont, California);  Alexander K. Zettl (Kensington, California)
ABSTRACT This disclosure provides systems, methods, and device associated with an electrostatically driven graphene speaker. In one aspect, the device includes a graphene membrane having a diameter of about 3 millimeters to about 11 millimeters, and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device is a microphone or a loudspeaker.
FILED Friday, August 14, 2020
APPL NO 16/993882
ART UNIT 2651 — Videophones and Telephonic Communications
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 15/00 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 19/02 (20130101)
H04R 19/005 (20130101) Original (OR) Class
H04R 23/002 (20130101)
H04R 29/001 (20130101)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/733 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 11246503 Lupton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) Myolex Inc (Brookline, Massachusetts)
ASSIGNEE(S) Myolex Inc. (Brookline, Massachusetts)
INVENTOR(S) Elmer C. Lupton (Charlestown, Massachusetts);  Haydn Taylor (Windham, New Hampshire);  Jose L. Bohorquez (Brookline, Massachusetts);  Ken Li (Wellesley, Massachusetts);  Michael Rinehart (San Jose, California)
ABSTRACT Embodiments of devices and methods for evaluating tissue are disclosed. In one embodiment, a method for measuring a characteristic of a tissue may include passing a current through the tissue, measuring a signal corresponding to the voltage resulting from passing the current through the tissue, analyzing current passed through the tissue and resulting voltage to determine the electrical characteristics of the tissue; and analyzing the electrical characteristics of the tissue to determine a status of the tissue. Disposable sensors are disclosed.
FILED Thursday, August 01, 2019
APPL NO 16/529725
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/053 (20130101) Original (OR) Class
A61B 5/486 (20130101)
A61B 5/0537 (20130101)
A61B 5/684 (20130101)
A61B 5/742 (20130101)
A61B 5/4519 (20130101)
A61B 5/6832 (20130101)
A61B 5/6833 (20130101)
A61B 5/6843 (20130101)
A61B 5/7221 (20130101)
A61B 5/7225 (20130101)
A61B 5/7228 (20130101)
A61B 5/7235 (20130101)
A61B 5/7278 (20130101)
A61B 5/7405 (20130101)
A61B 5/7475 (20130101)
A61B 2017/0023 (20130101)
A61B 2560/0412 (20130101)
A61B 2560/0431 (20130101)
A61B 2560/0443 (20130101)
A61B 2560/0468 (20130101)
A61B 2562/04 (20130101)
A61B 2562/14 (20130101)
A61B 2562/046 (20130101)
A61B 2562/164 (20130101)
A61B 2562/166 (20130101)
A61B 2562/0223 (20130101)

Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps
F04C 2270/041 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246504 Rutkove et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
APPLICANT(S) Myolex Inc. (Brookline, Massachusetts)
ASSIGNEE(S) Myolex Inc. (Brookline, Massachusetts)
INVENTOR(S) Seward Rutkove (Brookline, Massachusetts);  Elmer C Lupton (Charlestown, Massachusetts);  Jose L. Bohorquez (Burlingame, California);  Haydn Taylor (Windham, New Hampshire);  Gonzalo Cespedes (Daly City, California);  Cary Liberman (Oakland, California);  Dmitri Khrebtukov (San Francisco, California);  Claudio Cassina (Hollywood, Florida);  Yensy Hall (Pembroke Pines, Florida);  Stanislava Daraskevich (San Francisco, California);  Juan Jaramillo (San Francisco, California)
ABSTRACT A portable device for measuring a bioimpedance-related property of tissue includes a plurality of electrodes arranged in a pattern on a surface and associated software for measuring bio-impedance related data of localized regions of tissue and calculate health-related parameters based on the measured data. These calculated parameters may be representative of muscular health of the localized tissue region.
FILED Monday, January 06, 2020
APPL NO 16/735648
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0004 (20130101)
A61B 5/486 (20130101)
A61B 5/0537 (20130101) Original (OR) Class
A61B 5/742 (20130101)
A61B 5/4519 (20130101)
A61B 5/4872 (20130101)
A61B 5/7278 (20130101)
A61B 2560/0425 (20130101)
A61B 2562/043 (20130101)
A61B 2562/0214 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246543 Tai et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) WASHINGTON UNIVERSITY (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Yuan-Chuan Tai (St. Louis, Missouri);  Jie Wen (St. Louis, Missouri);  Ke Li (St. Louis, Missouri);  Aswin John Mathews (St. Louis, Missouri)
ABSTRACT A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector panel, a tracking system configured to detect a position of said second detector panel relative to the first detector panel while imaging a subject, a computing device in communication with the first detector panel, the second detector panel, and the tracking system, the computing device configured to receive coincidence data from the first and second detector panels, receive position data from the tracking system, wherein each coincidence datum of the received coincidence data is associated with a unique position datum of the received position data, and reconstruct a plurality of images based on the received coincidence data and the received position data.
FILED Thursday, November 12, 2015
APPL NO 15/524699
ART UNIT 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 6/025 (20130101)
A61B 6/037 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/2985 (20130101)

Image Data Processing or Generation, in General
G06T 11/003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246937 Mayes et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S) Sarah Mayes (Austin, Texas);  Christine Schmidt (Gainesville, Florida)
ABSTRACT The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
FILED Wednesday, March 20, 2019
APPL NO 16/358948
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/738 (20130101)
A61K 47/36 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11246956 Pokorski
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Jonathan Pokorski (San Diego, California)
ABSTRACT A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
FILED Monday, March 16, 2020
APPL NO 16/820158
ART UNIT 1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/02 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 15/26 (20130101) Original (OR) Class
A61L 15/26 (20130101)
A61L 15/26 (20130101)
A61L 15/44 (20130101)
A61L 15/425 (20130101)
A61L 27/18 (20130101)
A61L 27/18 (20130101)
A61L 27/18 (20130101)
A61L 27/34 (20130101)
A61L 27/34 (20130101)
A61L 27/56 (20130101)
A61L 27/60 (20130101)
A61L 2400/12 (20130101)

Compositions of Macromolecular Compounds
C08L 67/04 (20130101)
C08L 67/04 (20130101)
C08L 71/02 (20130101)
C08L 71/02 (20130101)
C08L 71/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247207 Jokerst et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S) Duke University (Durham, North Carolina)
INVENTOR(S) Nan Marie Jokerst (Durham, North Carolina);  Aditi Dighe (Durham, North Carolina);  Richard Fair (Durham, North Carolina)
ABSTRACT Microfluidic systems having photodetectors disclosed therein and methods of producing the same are disclosed herein. According to an aspect, a microfluidic system includes a body including an interior wall that at least partially defines an interior space for receipt of fluid. Further, the microfluidic system includes a photodetector disposed on the interior wall and positioned to receive light from fluid in the interior space for generating an electrical signal representative of the received light.
FILED Wednesday, October 16, 2019
APPL NO 16/654657
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502715 (20130101) Original (OR) Class
B01L 2300/12 (20130101)
B01L 2300/168 (20130101)
B01L 2300/0663 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/035281 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247230 Constantinou et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S) The University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) THE UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
INVENTOR(S) Jason Constantinou (Beaverton, Oregon);  Hanna Dodiuk-Kenig (Haifa, Israel);  Carol M. F. Barry (Tyngsborough, Massachusetts);  Samuel Kenig (Haifa, Israel);  Joey L. Mead (Carlisle, Massachusetts);  Artee Panwar (Wilmington, Massachusetts);  Tehila Nahum (Holon, Israel);  Sagar Mitra (Lowell, Massachusetts)
ABSTRACT An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90° and a sliding angle of less than 10° and, less than 5% of an area of the layer is removed in a Tape test.
FILED Monday, November 25, 2019
APPL NO 16/693762
ART UNIT 1715 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Processes for Applying Fluent Materials to Surfaces, in General
B05D 3/067 (20130101)
B05D 3/0254 (20130101)
B05D 5/00 (20130101)
B05D 5/08 (20130101) Original (OR) Class
B05D 5/083 (20130101)
B05D 2601/22 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 59/022 (20130101)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2827/18 (20130101)
B29K 2863/00 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/36 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/00 (20130101)
C09D 7/69 (20180101)

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 1/10 (20130101)
C25D 1/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247905 Rubin et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Yves Rubin (Los Angeles, California);  Robert S. Jordan (Los Angeles, California);  Yolanda L. Li (Los Angeles, California);  Ryan D. McCurdy (Los Angeles, California);  Simon Kervyn De Meerendré (Los Angeles, California)
ABSTRACT A method of forming a graphene nanoribbon includes: 1) providing monomeric precursors each including an alkyne moiety and at least one aromatic moiety bonded to the alkyne moiety; 2) polymerizing the monomeric precursors to form a polymer; and 3) converting the polymer to a graphene nanoribbon.
FILED Friday, November 17, 2017
APPL NO 16/461335
ART UNIT 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/184 (20170801) Original (OR) Class
C01B 2204/06 (20130101)
C01B 2204/22 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/72 (20130101)
C01P 2002/82 (20130101)
C01P 2002/84 (20130101)
C01P 2002/85 (20130101)
C01P 2002/86 (20130101)
C01P 2002/89 (20130101)
C01P 2002/90 (20130101)
C01P 2004/02 (20130101)
C01P 2004/03 (20130101)
C01P 2004/04 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 38/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247914 Talapin et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois)
INVENTOR(S) Dmitri V. Talapin (Riverside, Illinois);  Vishwas Srivastava (Chicago, Illinois)
ABSTRACT Methods of synthesizing colloidal ternary Group III-V nanocrystals are provided. Also provided are the colloidal ternary Group III-V nanocrystals made using the methods. In the methods, molten inorganic salts are used as high temperature solvents to carry out cation exchange reactions that convert binary nanocrystals into ternary nanocrystals.
FILED Wednesday, June 26, 2019
APPL NO 16/452949
ART UNIT 1738 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)
B82Y 30/00 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 15/003 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/01 (20130101)
C01P 2002/72 (20130101)
C01P 2002/82 (20130101)
C01P 2004/04 (20130101)
C01P 2004/64 (20130101)
C01P 2006/60 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11247940 Sant et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Tempe, Arizona)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Arizona Board of Regents (Tempe, Arizona)
INVENTOR(S) Gaurav Sant (Los Angeles, California);  Laurent G. Pilon (Los Angeles, California);  Bu Wang (Los Angeles, California);  Narayanan Neithalath (Chandler, Arizona);  Zhenhua Wei (Los Angeles, California);  Benjamin Young (Los Angeles, California);  Gabriel D. Falzone (Los Angeles, California);  Dante Simonetti (Los Angeles, California)
ABSTRACT A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.
FILED Friday, September 28, 2018
APPL NO 16/147261
ART UNIT 1774 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/087 (20130101)
B01J 19/245 (20130101)
B01J 2219/24 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 7/19 (20130101) Original (OR) Class
C04B 7/38 (20130101)
C04B 7/46 (20130101)
C04B 7/367 (20130101)
C04B 9/20 (20130101)
C04B 18/067 (20130101)
C04B 28/04 (20130101)
C04B 28/04 (20130101)
C04B 40/0231 (20130101)
C04B 2111/00017 (20130101)
C04B 2111/00129 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248217 Chundawat et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Rutgers, the State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Shishir Chundawat (New Brunswick, New Jersey);  Chandra Kanth Bandi (New Brunswick, New Jersey)
ABSTRACT The present invention relates to engineered carbohydrate-active enzyme constructs that are useful for glycan polymers synthesis. The construct comprises a CD domain from a GH, wherein the domain is conjugated to CBM3a via a peptidic linker. The invention also relates to a method of improving glycan polymer synthesis by using engineered carbohydrate active enzymes comprising a CD domain and CBM3a.
FILED Tuesday, August 20, 2019
APPL NO 16/545786
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1048 (20130101)
C12N 9/2402 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11248995 Albrecht et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Worcester Polytechnic Institute (Worcester, Massachusetts)
ASSIGNEE(S) Worcester Polytechnic Institute (Worcester, Massachusetts)
INVENTOR(S) Dirk Albrecht (Worcester, Massachusetts);  Ross Lagoy (Worcester, Massachusetts);  Kyra Burnett (Worcester, Massachusetts)
ABSTRACT Devices and methods for capturing and imaging a specimen, such as a living organism, are disclosed. In some embodiments, a method for imaging a living organism in vivo includes placing at least one specimen into a hydrogel polymer on a substrate, and curing the hydrogel to embed the at least one specimen within the cured hydrogel such that the at least one specimen is kept alive and the movement of the at least one specimen within the cured hydrogel is restricted. The at least one embedded specimen can be imaged.
FILED Wednesday, September 12, 2018
APPL NO 16/129581
ART UNIT 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/30 (20130101) Original (OR) Class
G01N 1/36 (20130101)
G01N 1/44 (20130101)
G01N 21/6458 (20130101)
G01N 21/6486 (20130101)
G01N 33/4833 (20130101)
G01N 2001/305 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249100 Albrecht et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Worcester Polytechnic Institute (Worcester, Massachusetts)
ASSIGNEE(S) Worcester Polytechnic Institute (Worcester, Massachusetts)
INVENTOR(S) Dirk Albrecht (Worcester, Massachusetts);  Ross Lagoy (Worcester, Massachusetts)
ABSTRACT Systems and methods for delivering fluid to a microfluidic device is provided. The system includes a multi-well plate having a plurality of wells and an inlet tube having a first end being in communication with the one or more wells of the multi-well plate and a second end being in communication with a microfluidic device. The first end of the inlet tube is moveable between the plurality of wells of the multi-well plate to deliver fluid to the microfluidic device from the plurality of wells of the multi-well plate.
FILED Saturday, January 05, 2019
APPL NO 16/240720
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/0293 (20130101)
B01L 3/502715 (20130101)
B01L 3/502738 (20130101)
B01L 2200/027 (20130101)
B01L 2200/146 (20130101)
B01L 2200/0615 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0829 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 35/109 (20130101)
G01N 35/1011 (20130101)
G01N 35/1016 (20130101)
G01N 35/1072 (20130101) Original (OR) Class
G01N 35/1095 (20130101)
G01N 35/1097 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251270 Jain
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Electrical and Communications Systems (ECS)
APPLICANT(S) Faquir Chand Jain (Storrs, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Faquir Chand Jain (Storrs, Connecticut)
ABSTRACT This invention includes multiple quantum well and quantum dot channel FETs, which can process multi-state/multi-bit logic, and multibit-bit inverters configured as static random-access memories (SRAMs). SRAMs can be implemented as flip-flops and registers. In addition, multiple quantum well and quantum dot channel structures are configured to function as multi-bit high-speed quantum dot (QD) random access memories (NVRAMs). Multi-bit Logic, SRAMs and QD-NVRAMs are spatially located on a chip, depending on the application, to provide a low-power consumption and high-speed hardware platform. The multi-bit logic, SRAM and register, and QD-NVRAM are implemented on a single chip in a CMOS-like platform for applications including artificial intelligence (AI) and machine learning.
FILED Thursday, May 21, 2020
APPL NO 16/880569
ART UNIT 2828 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/092 (20130101)
H01L 27/1104 (20130101)
H01L 27/11521 (20130101)
H01L 29/151 (20130101) Original (OR) Class
H01L 29/1054 (20130101)
H01L 29/7887 (20130101)
H01L 29/42332 (20130101)
H01L 29/66825 (20130101)
H01L 29/66977 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251385 Ellingson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The University of Toledo (Toledo, Ohio)
ASSIGNEE(S) The University of Toledo (Toledo, Ohio)
INVENTOR(S) Randall J. Ellingson (Toledo, Ohio);  Khagendra P. Bhandari (Toledo, Ohio);  Michael Heben (Toledo, Ohio);  Suneth Watthage (Toledo, Ohio);  Zhaoning Song (Toledo, Ohio)
ABSTRACT Hole transport layers, electron transport layers, layer stacks, and optoelectronic devices involving perovskite materials and materials used as precursors, and methods of making the same, are described.
FILED Friday, January 26, 2018
APPL NO 15/880807
ART UNIT 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/302 (20130101)
H01L 51/0077 (20130101)
H01L 51/424 (20130101)
H01L 51/441 (20130101)
H01L 51/4213 (20130101) Original (OR) Class
H01L 2031/0344 (20130101)
H01L 2251/301 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/549 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251859 Paramesh et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) Jeyanandh Paramesh (Pittsburgh, Pennsylvania);  Susnata Mondal (Pittsburgh, Pennsylvania)
ABSTRACT A reconfigurable, multi-band hybrid beamforming architecture is introduced. The present invention is related to a Cartesian-Combining architecture to efficiently implement RF beamforming for a single downconversion chain employing direct downconversion in which the Cartesian-Combining architecture is extended to hybrid beamforming and to heterodyne downconversion.
FILED Monday, December 07, 2020
APPL NO 17/113288
ART UNIT 2632 — Digital Communications
CURRENT CPC
Transmission
H04B 1/16 (20130101)
H04B 1/0028 (20130101)
H04B 1/0078 (20130101)
H04B 7/088 (20130101) Original (OR) Class
H04B 7/0413 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251881 Becnel et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S) UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S) Thomas Becnel (Salt Lake City, Utah);  Pierre-Emmanuel Gaillardon (Salt Lake City, Utah);  Kerry Elizabeth Kelly (Salt Lake City, Utah)
ABSTRACT A computer system for recursive calibration of a sensor network receives a first data communication from a first sensor node that is a neighbor to a calibrated sensor node. The computer system then updates a set of linear regressions between the first sensor node and a set of neighboring sensor nodes, which include the neighboring, calibrated sensor node. The computer system calibrates the first sensor node using an average of the set of linear regressions weighted by a correlation. When the first sensor node is calibrated, the computer system uses the calibrated first sensor node in calibration of a neighboring, uncalibrated sensor node. The computer system then gathers, at the first sensor node, a calibrated sensor reading.
FILED Friday, May 29, 2020
APPL NO 16/888270
ART UNIT 2449 — Computer Networks
CURRENT CPC
Transmission
H04B 17/11 (20150115) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/12 (20130101)
H04L 67/12 (20130101)
H04L 67/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252079 Michael et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) VMware, Inc. (Palo Alto, California)
ASSIGNEE(S) VMWARE, INC. (Palo Alto, California)
INVENTOR(S) Nithin Michael (San Francisco, California);  Ao Tang (San Francisco, California);  Victor de Souza Lima e Silva (San Francisco, California);  Thiago Sousa Santos (San Francisco, California);  Ning Wu (San Francisco, California);  Archit Baweja (San Francisco, California);  Ki Suh Lee (San Francisco, California);  Yao Wang (San Francisco, California);  Andrey Gushchin (San Francisco, California);  Sakethnath Are (San Francisco, California)
ABSTRACT A system comprising nodes configured to form a network including virtual links in an overlay network provisioned over an underlay network. The system includes tenant networks formed in the network, and each tenant network corresponds to a tenant of the network. The system includes control planes, and each control plane is a component of a tenant network and includes routing algorithms corresponding to traffic classes. The tenant network is configured to use feedback data of link conditions of the tenant network with at least one routing algorithm to control routing of tenant traffic of a corresponding traffic class.
FILED Sunday, December 02, 2018
APPL NO 16/207156
ART UNIT 2467 — Multiplex and VoIP
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 43/0864 (20130101)
H04L 43/0876 (20130101)
H04L 45/22 (20130101) Original (OR) Class
H04L 45/24 (20130101)
H04L 45/745 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252263 Guimaraes et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Vinicius Galvao Guimaraes (Santa Cruz, California);  Katia Obraczka (Santa Cruz, California);  Adolfo Bauchspiess (Santa Cruz, California);  Renato Mariz de Moraes (Santa Cruz, California)
ABSTRACT Techniques for efficient communication packet generation in internet of things (IOT) include presenting an application programming interface to each of a plurality of protocols in a plurality of different layers of a network communications protocol stack. A single packet buffer is configured in memory to hold headers for all of the plurality of protocols for a packet directed to a first destination node. Pointers are also stored in memory to tables maintained by the plurality of protocols. In response to receiving input at the application programming interface from a first protocol, at least one bit is updated in the single packet buffer based on the input and on data in a table maintained by a different second protocol of the plurality of protocols.
FILED Monday, June 29, 2020
APPL NO 16/914778
ART UNIT 2473 — Multiplex and VoIP
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 49/90 (20130101)
H04L 69/16 (20130101) Original (OR) Class
H04L 69/22 (20130101)

Wireless Communication Networks
H04W 28/0278 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11252512 Zhou et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California at Berkeley, CA (UC BERKELEY)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Qin Zhou (Fremont, California);  Alexander K. Zettl (Kensington, California)
ABSTRACT This disclosure provides systems, methods, and device associated with an electrostatically driven graphene speaker. In one aspect, the device includes a graphene membrane having a diameter of about 3 millimeters to about 11 millimeters, and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device is a microphone or a loudspeaker.
FILED Friday, August 14, 2020
APPL NO 16/993882
ART UNIT 2651 — Videophones and Telephonic Communications
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 15/00 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 19/02 (20130101)
H04R 19/005 (20130101) Original (OR) Class
H04R 23/002 (20130101)
H04R 29/001 (20130101)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/733 (20130101)
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US RE48928 Strongin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
APPLICANT(S) Portland State University (Portland, Oregon)
ASSIGNEE(S) Portland State University (Portland, Oregon)
INVENTOR(S) Robert Strongin (Portland, Oregon);  Martha Sibrian-Vazquez (Portland, Oregon);  Jialu Wang (Portland, Oregon);  Lei Wang (Camas, Washington);  Jorge O. Escobedo-Cordova (Portland, Oregon)
ABSTRACT Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.
FILED Friday, April 24, 2020
APPL NO 16/858380
ART UNIT 3991 — Central Reexamination Unit (Chemical)
CURRENT CPC
Heterocyclic Compounds
C07D 491/22 (20130101)
C07D 491/107 (20130101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 11/24 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/92 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 11248622 Evans et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Glenn Research Center (GLENN)
APPLICANT(S) United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S) Simon W. Evans (Farmington, Connecticut);  Yuan Dong (Glastonbury, Connecticut);  Sean Nolan (Wethersfield, Connecticut)
ABSTRACT A compressor section for a gas turbine engine includes a blade including a platform, a tip and an airfoil extending between the platform and tip. The airfoil includes a root portion adjacent to the platform, a midspan portion and a tip portion. Each of the root portion, midspan portion and tip portion define a meridional velocity at stage exit with the tip portion including a first meridional velocity greater than a second meridional velocity of the midspan portion. A blade for an axial compressor of a gas turbine engine and a method of operating a compressor section of a gas turbine engine are also disclosed.
FILED Friday, September 02, 2016
APPL NO 15/255663
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/145 (20130101)

Non-positive-displacement Pumps
F04D 19/02 (20130101)
F04D 29/324 (20130101)
F04D 29/384 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2210/30 (20130101)
F05D 2220/3216 (20130101)
F05D 2240/307 (20130101)
F05D 2260/821 (20130101)
F05D 2270/3013 (20130101)

Climate Change Mitigation Technologies Related to Transportation
Y02T 50/60 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249221 Mecikalski
FUNDED BY
National Aeronautics and Space Administration (NASA)
Langley Research Center (LaRC)
NASA Shared Services Center (NSSC)
APPLICANT(S) John R. Mecikalski (Madison, Alabama)
ASSIGNEE(S) Board of Trustees of the University of Alabama (Huntsville, Alabama)
INVENTOR(S) John R. Mecikalski (Madison, Alabama)
ABSTRACT A weather forecasting system has a data processing system that receives weather data from one or more sources and processes such data in conjunction with a weather forecasting algorithm in order to forecast weather for one or more geographic regions. In this regard, the weather data is input into a machine learning algorithm, which applies learned weights and relationships to the inputs in order to calculate at least one score indicating a probability that precipitation or other weather event will occur in the future within a certain time period (e.g., within the next 1 hour or some other unit of time) in one or more geographic regions. For each such geographic region, the weather forecasting logic may also predict the extent to which rain or other precipitation, lightning, or other weather event will occur during the time period.
FILED Friday, January 29, 2021
APPL NO 17/162517
ART UNIT 2812 — Semiconductors/Memory
CURRENT CPC
Meteorology
G01W 1/10 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 17/10 (20130101)
G06F 30/20 (20200101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Image Data Processing or Generation, in General
G06T 2207/30192 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11249479 Thakur et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Nissan North America, Inc. (Franklin, Tennessee);  United States of America as Represented by the Administrator of NASA (Washington, District of Columbia);  Renault S.A.S. (Boulogne-Billancourt, France)
ASSIGNEE(S) Nissan North America, Inc. (Franklin, Tennessee);  Renault S.A.S. (Boulogne-Billancourt, France)
INVENTOR(S) Siddharth Thakur (Paris, France);  Armelle Guerin (Woodside, California);  Julius S. Gyorfi (Vernon Hills, Illinois);  Kevin Poulet (Menlo Park, California);  Aude Laurent (Redwood City, California);  Mark Allan (Campbell, California);  Omar Bentahar (Sunnyvale, California)
ABSTRACT A method of exception handing for an autonomous vehicle (AV) includes identifying an exception situation; identifying relevant sensors for the exception situation; identifying relevant tools to the exception situation, the relevant tools usable by a tele-operator to resolve the exception situation; and presenting, on a display of the tele-operator, data from the relevant sensors and the relevant tools.
FILED Thursday, July 18, 2019
APPL NO 16/515667
ART UNIT 3665 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Systems for Controlling or Regulating Non-electric Variables
G05D 1/0088 (20130101) Original (OR) Class
G05D 1/0246 (20130101)
G05D 1/0276 (20130101)
G05D 2201/0213 (20130101)

Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere
G07C 5/008 (20130101)
G07C 5/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251420 Chou et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
Federally Funded Research and Development Center (FFRDC)
Operated by California Institute of Technology at Pasadena, CA (CALTECH)
APPLICANT(S) HONDA MOTOR CO., LTD. (Tokyo, Japan);  CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S) HONDA MOTOR CO., LTD. (Tokyo, Japan);  CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S) Nam Hawn Chou (Dublin, Ohio);  Kaoru Omichi (Columbus, Ohio);  Ryan McKenney (Upper Arlington, Ohio);  Qingmin Xu (Columbus, Ohio);  Christopher Brooks (Dublin, Ohio);  Simon C. Jones (Azusa, California);  Isabelle M. Darolles (Azusa, California);  Hongjin Tan (Pasadena, California)
ABSTRACT The present disclosure relates to a method of making core-shell and yolk-shell nanoparticles, and to electrodes comprising the same. The core-shell and yolk-shell nanoparticles and electrodes comprising them are suitable for use in electrochemical cells, such as fluoride shuttle batteries. The shell may protect the metal core from oxidation, including in an electrochemical cell. In some embodiments, an electrochemically active structure includes a dimensionally changeable active material forming a particle that expands or contracts upon reaction with or release of fluoride ions. One or more particles are at least partially surrounded with a fluoride-conducting encapsulant and optionally one or more voids are formed between the active material and the encapsulant using sacrificial layers or selective etching. When the electrochemically active structures are used in secondary batteries, the presence of voids can accommodate dimensional changes of the active material.
FILED Friday, December 15, 2017
APPL NO 15/844079
ART UNIT 1727 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/62 (20130101)
H01M 4/134 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 4/582 (20130101)
H01M 4/1395 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11251582 Petros et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S) UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
INVENTOR(S) Mulugeta Petros (Newport News, Virginia);  Tamer Refaat (Hampton, Virginia);  Upendra N. Singh (Yorktown, Virginia);  Charles W. Antill (Hampton, Virginia)
ABSTRACT Aspects of the present disclosure are directed to methods and apparatuses for generating laser light. As may be implemented in accordance with one or more embodiments, laser light is generated at a laser light source and is modulated in response to a frequency modulation signal, to generate a plurality of different wavelengths of laser light. The frequency modulation signal is generated, for each particular one of the wavelengths of laser light, at a respective seeding frequency corresponding to the particular one of the wavelengths in which the seeding frequency is different for each of the different wavelengths. Such an approach may, for example, involve generating the frequency modulation signal with a frequency generator circuit and using the frequency modulation signal to control an electro-optical modulator for modulating the wavelength of the laser light.
FILED Wednesday, February 20, 2019
APPL NO 16/280628
ART UNIT 2828 — Semiconductors/Memory
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/108 (20130101)
H01S 3/117 (20130101)
H01S 3/1003 (20130101)
H01S 3/1106 (20130101)
H01S 3/1303 (20130101)
H01S 3/2375 (20130101)
H01S 3/06754 (20130101)
H01S 3/10015 (20130101)
H01S 3/10092 (20130101)
H01S 5/0085 (20130101)
H01S 5/0687 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 11246806 Kearns et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) William Diehl Kearns (Tampa, Florida);  Kimberly Ann Crosland (Lithia, Florida);  Jeffrey D. Craighead (Groveland, Florida);  James Leonard Fozard (Palm Harbor, Florida)
ASSIGNEE(S) THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia);  UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida)
INVENTOR(S) William Diehl Kearns (Tampa, Florida);  Kimberly Ann Crosland (Lithia, Florida);  Jeffrey D. Craighead (Groveland, Florida);  James Leonard Fozard (Palm Harbor, Florida)
ABSTRACT A medication adherence system and corresponding medication box for improving medication adherence. The system includes the medication box, which is transparent and has a machine-readable marker, such as a QR code, on or beneath the floor thereof. The marker is capable of being scanned and read through the transparent bottoms of individual chambers. Data embedded in the marker includes, but is not limited to, the user's medication plan, the date and time when the medication is to be ingested, and instructions for recording the date and time when the marker is scanned and read. The underlying software program/application processes this information and provides an indication as to the user's compliance with the medication plan.
FILED Friday, November 03, 2017
APPL NO 15/802635
ART UNIT 3736 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle
A61J 7/0069 (20130101)
A61J 7/0076 (20130101)
A61J 7/0092 (20130101)
A61J 7/0418 (20150501)
A61J 7/0445 (20150501)
A61J 7/0481 (20130101) Original (OR) Class
A61J 2200/30 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 19/06028 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/13 (20180101)
G16H 70/40 (20180101)
VIEW PATENT @ USPTO: