FedInvent™ Patents

Patent Details for Tuesday, May 24, 2022

This page was updated on Thursday, May 26, 2022 at 07:05 PM GMT

Department of Health and Human Services (HHS)

11337604 — In vivo object identification, counting, and imaging based on light backscattered from a plane behind the object

US 11337604	Guevara-Torres et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	University of Rochester (Rochester, New York)
ASSIGNEE(S)	University of Rochester (Rochester, New York)
INVENTOR(S)	Raul Andres Guevara-Torres (Rochester, New York); Jesse Schallek (Rush, New York); Aby Joseph (Rochester, New York)
ABSTRACT	A method to image an in vivo object in an eye includes illuminating an object in the eye by a light source; configuring one or more detectors to receive light from a conjugate plane behind a confocal plane of the object, the conjugate plane acting as a light screen; receiving at the one or more detectors a backscattered light from the light source which has been refracted at least in part by the object before being backscattered from the light screen to provide a detector data; and processing the detector data over a time period by a computer to generate information about the object.
FILED	Tuesday, October 22, 2019
APPL NO	16/660312
ART UNIT	2872 — Optics
CURRENT CPC	Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/0025 (20130101) A61B 3/1025 (20130101) Original (OR) Class A61B 3/1241 (20130101)
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11337643 — Machine learning systems and techniques for multispectral amputation site analysis

US 11337643	Fan et al.
FUNDED BY	Department of Health and Human Services (HHS) Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	SPECTRAL MD, INC. (Dallas, Texas)
ASSIGNEE(S)	Spectral MD, Inc. (Dallas, Texas)
INVENTOR(S)	Wensheng Fan (Plano, Texas); John Michael DiMaio (Dallas, Texas); Jeffrey Thatcher (Irving, Texas)
ABSTRACT	Certain aspects relate to apparatuses and techniques for non-invasive and non-contact optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications including assessing the presence and severity of tissue conditions, such as necrosis and small vessel disease, at a potential or determined amputation site.
FILED	Monday, August 24, 2020
APPL NO	17/000810
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/443 (20130101) A61B 5/445 (20130101) Original (OR) Class A61B 5/02007 (20130101) A61B 5/7267 (20130101) Image or Video Recognition or Understanding G06V 10/751 (20220101)
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11337647 — Quantification of in vivo metabolite

US 11337647	Reddy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute on Drug Abuse (NIDA) Non-Profit Organization (NPO) Susan G. Komen Foundation (SGKF)
APPLICANT(S)	The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Ravinder Reddy (Gladwynne, Pennsylvania); Ravi Prakash Reddy Nanga (Philadelphia, Pennsylvania); Hari Hariharan (Mount Laurel, New Jersey)
ABSTRACT	A magnetic resonance pulse sequence technique may acquire a water reference spectrum and two water suppressed metabolite spectra and with frequency selective inversion pulse centered at either single frequency, at multiple frequencies, or in a single acquisition. Subtraction of the inverted from non-inverted water suppressed metabolite spectrum results in single or a combination of specific metabolite peak/peaks alone with a flat baseline for easier quantification.
FILED	Friday, April 04, 2014
APPL NO	14/782472
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4064 (20130101) A61B 5/4839 (20130101) A61B 5/4848 (20130101) Original (OR) Class A61B 5/4866 (20130101) A61B 5/14546 (20130101) A61B 2560/0475 (20130101) A61B 2576/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/483 (20130101) G01R 33/5601 (20130101) G01R 33/5605 (20130101)
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11337753 — Tissue cutting systems and methods

US 11337753	Rafiee et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH)
APPLICANT(S)	Telltale LLC (Andover, Massachusetts); The National Institutes of Health (NIH) (Bethseda, Maryland)
ASSIGNEE(S)	Telltale LLC (Andover, Massachusetts); The National Institutes of Health (NIH) (Bethseda, Maryland)
INVENTOR(S)	Nasser Rafiee (Andover, Massachusetts); Robert J Lederman (Bethseda, Maryland); Rany Busold (Andover, Massachusetts); Morgan House (Andover, Massachusetts); Jaffar Khan (Bethseda, Maryland); Toby Rogers (Bethseda, Maryland); Christopher G Bruce (Bethseda, Maryland)
ABSTRACT	The disclosure provides various embodiments of systems to facilitate the cutting of luminal tissue structures percutaneously.
FILED	Wednesday, January 13, 2021
APPL NO	17/148170
ART UNIT	3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 18/1206 (20130101) A61B 18/1492 (20130101) Original (OR) Class A61B 2017/00867 (20130101) A61B 2018/144 (20130101) A61B 2018/00351 (20130101) A61B 2018/00601 (20130101) A61B 2090/3966 (20160201) A61B 2218/002 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/09 (20130101) A61M 2025/09166 (20130101)
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11337799 — Stentless biopolymer heart valve replacement capable of living tissue regeneration

US 11337799	Badhwar et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Vinay Badhwar (Washington, Pennsylvania); Antonio D'Amore (Pittsburgh, Pennsylvania); Yasumoto Matsumura (Pittsburgh, Pennsylvania); William R. Wagner (Gibsonia, Pennsylvania)
ABSTRACT	A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.
FILED	Friday, February 23, 2018
APPL NO	16/488002
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/24 (20130101) A61F 2/2409 (20130101) A61F 2/2412 (20130101) A61F 2/2415 (20130101) Original (OR) Class A61F 2/2457 (20130101) A61F 2230/0023 (20130101) A61F 2240/005 (20130101)
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11337832 — Socket-suspension monitoring system for amputees

US 11337832	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)
APPLICANT(S)	NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Ming Liu (Cary, North Carolina); He Huang (Cary, North Carolina)
ABSTRACT	A continuous socket/suspension monitoring system according to principles of the present invention tracks relative displacement between amputee residuum and their socket using magnetic sensors. The system includes at least one magnetic sensor in a liner worn on the amputees' residuum which correspond to sensors provide in or on the prosthesis socket. The system allows for monitoring of pistoning continuously during locomotion and does not require socket modification, is safe to amputee patients, is easy to use, and is low cost.
FILED	Friday, March 23, 2018
APPL NO	16/496756
ART UNIT	3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) A61F 2/76 (20130101) Original (OR) Class A61F 2/80 (20130101) A61F 2002/763 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/16 (20130101)
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11337881 — Exoskeleton with admittance control

US 11337881	Corrigan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)
APPLICANT(S)	New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S)
INVENTOR(S)	Madeline Corrigan (West Caldwell, New Jersey); Richard Foulds (Yardley, Pennsylvania)
ABSTRACT	A control system and method for an exoskeleton is provided. The control system utilizes the admittance control paradigm to provide a system and method for manipulating the exoskeleton using minimal force from the user. A force/torque sensor and servo motors are fitted onto a passive arm support, enabling motorized support for a user with upper extremity weaknesses. The exoskeleton may be used on any extremity. The admittance control paradigm includes an impedance control and an admittance control to allow a user with upper extremity weakness and limited independence to intuitively and with minimal force control the precise trajectory of their arms to achieve a greater degree of independence in activities of daily living. Unlike existing passive arm supports that utilize springs or rubber bands to balance the user's arm against gravity, this system provides more precise gravity compensation and minimizes the amount of force required to control the exoskeleton.
FILED	Tuesday, August 21, 2018
APPL NO	16/107041
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0237 (20130101) A61H 1/0266 (20130101) A61H 1/0274 (20130101) A61H 1/0277 (20130101) A61H 1/0281 (20130101) A61H 1/0285 (20130101) A61H 1/0288 (20130101) A61H 1/0296 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2001/027 (20130101) A61H 2003/007 (20130101) A61H 2201/50 (20130101) A61H 2201/0107 (20130101) A61H 2201/164 (20130101) A61H 2201/0165 (20130101) A61H 2201/165 (20130101) A61H 2201/1215 (20130101) A61H 2201/1238 (20130101) A61H 2201/1607 (20130101) A61H 2201/1611 (20130101) A61H 2201/1638 (20130101) A61H 2201/1659 (20130101) A61H 2201/5023 (20130101) A61H 2201/5028 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2205/06 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/014 (20130101) G06F 3/0338 (20130101)
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11337930 — Modified alginates for cell encapsulation and cell therapy

US 11337930	Vegas et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S)	Arturo J. Vegas (Belmont, Massachusetts); Minglin Ma (Ithaca, New York); Kaitlin M. Bratlie (Ames, Iowa); Daniel G. Anderson (Framingham, Massachusetts); Robert S. Langer (Newton, Massachusetts)
ABSTRACT	Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
FILED	Monday, October 26, 2020
APPL NO	17/080355
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5036 (20130101) Original (OR) Class A61K 9/5161 (20130101) A61K 35/39 (20130101) A61K 45/06 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101)
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11337931 — Nanoparticle delivery system for diseases associated with major basement membrane components of blood vessels accessible from blood stream

US 11337931	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of South Florida (Tampa, Florida)
ASSIGNEE(S)	University of South Florida (Tampa, Florida)
INVENTOR(S)	Ruisheng Liu (Tampa, Florida); Samuel A. Wickline (Temple Terrace, Florida); Jin Wei (Tampa, Florida); Hua Pan (Tampa, Florida); Jie Zhang (Tampa, Florida)
ABSTRACT	A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.
FILED	Tuesday, November 17, 2020
APPL NO	16/950327
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5169 (20130101) A61K 31/436 (20130101) A61K 31/573 (20130101) A61K 31/675 (20130101) A61K 31/5377 (20130101) A61K 47/62 (20170801)
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11337963 — Compositions and methods of enhancing 5-hydroxytryptophan bioavailability

US 11337963	Jacobsen et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Mental Health (NIMH)
APPLICANT(S)	Duke University (Durham, North Carolina)
ASSIGNEE(S)	Duke University (Durham, North Carolina)
INVENTOR(S)	Jacob P. R. Jacobsen (Durham, North Carolina); Marc G. Caron (Hillsborough, North Carolina)
ABSTRACT	Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s).
FILED	Monday, January 28, 2019
APPL NO	15/733423
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/135 (20130101) A61K 31/138 (20130101) A61K 31/198 (20130101) A61K 31/343 (20130101) A61K 31/405 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/4406 (20130101) A61K 31/4525 (20130101)
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11337965 — Kinase mutation-associated neurodegenerative disorders

US 11337965	Geissmann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)	MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York)
INVENTOR(S)	Frederic Geissmann (New York, New York); Elvira Mass (New York, New York); Rocio Vicario (New York, New York)
ABSTRACT	The present technology relates to methods for treating, preventing, and/or ameliorating kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases, in a subject in need thereof. In particular aspects, the present technology relates to the use of BRAF, MEK, and/or CSF-IR inhibitors to treat, prevent, and/or ameliorate kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases.
FILED	Friday, August 24, 2018
APPL NO	16/640146
ART UNIT	1624 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101)
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11337968 — Phenylquinoline compositions for treatment of ocular disorders and conditions

US 11337968	Ma et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Eye Institute (NEI)
APPLICANT(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S)	Jian-xing Ma (Edmond, Oklahoma); Elizabeth Moran (Boston, Massachusetts); Guotao Deng (Oklahoma City, Oklahoma); Adam S. Duerfeldt (Norman, Oklahoma)
ABSTRACT	Compositions containing a phenylquinoline derivative compound having peroxisome proliferator-activated receptor a (PPARα) agonistic activity, and methods of their use in enhancing PPARα activity in retinal cells, and in treating ocular disorders or conditions, such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
FILED	Friday, April 28, 2017
APPL NO	16/097353
ART UNIT	1613 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/47 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101)
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11337971 — Dopamine D3 receptor selective antagonists/partial agonists and uses thereof

US 11337971	Newman et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
INVENTOR(S)	Amy Hauck Newman (Phoenix, Maryland); Vivek Kumar (Baltimore, Maryland); Anver Basha Shaik (Baltimore, Maryland)
ABSTRACT	Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders.
FILED	Monday, September 09, 2019
APPL NO	17/265150
ART UNIT	1625 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) A61K 31/496 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101)
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11337981 — Dual CLK/CDK1 inhibitors for cancer treatment

US 11337981	Webb et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	SRI INTERNATIONAL (Menlo Park, California)
ASSIGNEE(S)	SRI International (Menlo Park, California)
INVENTOR(S)	Thomas R. Webb (Mountain View, California); Jaehyeon Park (Sunnyvale, California); Chandraiah Lagisetti (Cupertino, California)
ABSTRACT	The disclosure generally relates to substituted purine analogs that are dual CLK2/CDK1 inhibitors or more potent and specific CLK inhibitors to target CLK2 and CDK1 kinases. These compounds may be useful in the treatment of germ-line mutations of the spliceosome leading to the development of cancers and other human disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Thursday, May 28, 2020
APPL NO	16/886290
ART UNIT	1699 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Original (OR) Class A61K 31/437 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 473/16 (20130101) C07D 473/32 (20130101) C07D 487/04 (20130101)
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11337988 — Use of ouabain antagonists to inhibit viral infection

US 11337988	Collins et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Peter Collins (Silver Spring, Maryland); Matthias Lingemann (Bethesda, Maryland); Shirin Munir (Potomac, Maryland)
ABSTRACT	Embodiments of a method for inhibiting viral infection in a subject are provided herein. In some embodiments, the method comprises administration of a competitive antagonist of ouabain binding to ATP1A1 to inhibit respiratory syncytial virus infection in the subject.
FILED	Thursday, September 26, 2019
APPL NO	16/584679
ART UNIT	1628 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 31/58 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101)
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11337994 — In situ gelling compositions for the treatment or prevention of inflammation and tissue damage

US 11337994	Ghandehari et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Hamidreza Ghandehari (Salt Lake City, Utah); Siam Oottamasathien (Salt Lake City, Utah); Mark Martin Jensen (Salt Lake City, Utah); Joseph Cappello (Salt Lake City, Utah); Wanjian Jia (Salt Lake City, Utah); Glenn D. Prestwich (Salt Lake City, Utah)
ABSTRACT	Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.
FILED	Thursday, September 14, 2017
APPL NO	16/333434
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 31/728 (20130101) A61K 31/737 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 14/78 (20130101)
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11338012 — BRAF-based polypeptides for treatment of cancer

US 11338012	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	UNIVERSITY OF THE SCIENCES (Philadelphia, Pennsylvania)
ASSIGNEE(S)	University of the Sciences (Philadelphia, Pennsylvania)
INVENTOR(S)	Zhihong Wang (Philadelphia, Pennsylvania); Zhijun Li (Bala Cynwyd, Pennsylvania); Amber Gunderwala (Havertown, Pennsylvania)
ABSTRACT	In one aspect, the invention provides a polypeptide derived from the dimer interface of BRAF, which is useful for treating various types of cancers. In certain embodiments, the polypeptide can be used to treat, prevent, and/or ameliorate a cancer such as but not limited to lung cancer.
FILED	Wednesday, May 13, 2020
APPL NO	15/930660
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/506 (20130101) A61K 38/12 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11338016 — C-terminal fragment of tetanus toxin (Hc) for treatment of depression

US 11338016	Tizabi
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	Howard University (Washington, District of Columbia)
ASSIGNEE(S)	HOWARD UNIVERSITY (Washington, District of Columbia)
INVENTOR(S)	Yousef Tizabi (Silver Spring, Maryland)
ABSTRACT	C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.
FILED	Wednesday, May 20, 2020
APPL NO	16/878809
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/164 (20130101) Original (OR) Class
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11338017 — Small peptide compositions and uses thereof

US 11338017	Yates-Binder et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Tuskegee University (Tuskegee, Alabama)
INVENTOR(S)	Cecelia C. Yates-Binder (Pittsburgh, Pennsylvania); Jesse Jaynes (Tuskegee, Alabama)
ABSTRACT	Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.
FILED	Friday, March 29, 2019
APPL NO	16/370603
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 35/00 (20180101) Peptides C07K 7/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101)
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11338032 — Methods of preparing anti-human papillomavirus antigen T cells

US 11338032	Hinrichs et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)	The United States of Americans represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Christian S. Hinrichs (Bethesda, Maryland); Steven A. Rosenberg (Potomac, Maryland)
ABSTRACT	Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
FILED	Monday, July 12, 2021
APPL NO	17/373130
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/12 (20130101) Original (OR) Class A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 7/00 (20130101) C12N 2501/2302 (20130101) C12N 2502/30 (20130101) C12N 2710/20011 (20130101)
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11338033 — Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

US 11338033	Boyington et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S)	Jeffrey C. Boyington (Clarksburg, Maryland); Barney S. Graham (Rockville, Maryland); John R. Mascola (Rockville, Maryland); Hadi M. Yassine (Doha, Qatar); Kizzmekia S. Corbett (Wheaton, Maryland); Syed M. Moin (Laurel, Maryland); Lingshu Wang (North Potomac, Maryland); Masaru Kanekiyo (Chevy Chase, Maryland)
ABSTRACT	Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
FILED	Friday, September 01, 2017
APPL NO	16/329592
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/16122 (20130101) C12N 2760/16134 (20130101)
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11338036 — Methods and compositions for the treatment and/or prevention of type 1 diabetes

US 11338036	Zaghouani
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Curators of the University of Missouri (Columbia, Missouri)
ASSIGNEE(S)	The Curators of the University of Missouri (Columbia, Missouri)
INVENTOR(S)	Habib Zaghouani (Columbia, Missouri)
ABSTRACT	The disclosure relates generally to methods and compositions of treating or preventing diabetes mellitus by administering to a subject a composition comprising an amount of stem and/or progenitor cells and at least one antigen-specific therapy.
FILED	Monday, March 10, 2014
APPL NO	14/773497
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/545 (20130101) A61K 38/10 (20130101) A61K 38/51 (20130101) A61K 38/1774 (20130101) A61K 39/39533 (20130101) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 2318/10 (20130101)
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11338065 — In situ expansion of engineered devices for regeneration

US 11338065	Bhatia et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts)
INVENTOR(S)	Sangeeta N. Bhatia (Lexington, Massachusetts); Kelly R. Stevens (Cambridge, Massachusetts); Christopher S. Chen (Newton, Massachusetts)
ABSTRACT	Engineered human tissue seed constructs are provided that are suitable for implantation in subjects. Methods of making and using the engineered tissue seed constructs are provided.
FILED	Friday, October 07, 2016
APPL NO	15/765526
ART UNIT	1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) Original (OR) Class A61L 27/225 (20130101) A61L 27/3804 (20130101) A61L 27/3808 (20130101) A61L 27/3886 (20130101) A61L 27/3891 (20130101) A61L 2430/28 (20130101)
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11338232 — Efficient non-clogging inertial vortex type particle scrubber

US 11338232	Schafrik et al.
FUNDED BY	Department of Health and Human Services (HHS) Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S)	Steven J. Schafrik (Lexington, Kentucky); Ashish Ranjan Kumar (Lexington, Kentucky); Allison Taylor (Lexington, Kentucky)
ABSTRACT	An inertial vortex particle scrubber includes a housing having an inlet guide, twin vortex chambers and an outlet. A particle-laden air stream is accelerated as it passes through the inlet guide into the twin vortex chambers where particles are displaced by centrifugal forces toward a wall of the twin vortex chambers. A relatively particle-free air stream is then discharged from the outlet.
FILED	Thursday, October 29, 2020
APPL NO	17/084073
ART UNIT	1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 45/16 (20130101) Original (OR) Class Apparatus Using Free Vortex Flow, e.g Cyclones B04C 5/04 (20130101) B04C 5/081 (20130101) B04C 5/103 (20130101)
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11338247 — Method of stem-based drilling of ultrathin silicon nitride nanopores and nanopore arrays

US 11338247	Drndic et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Marija Drndic (Philadelphia, Pennsylvania); Julio A. Rodriguez-Manzo (Philadelphia, Pennsylvania)
ABSTRACT	The invention concerns methods for preparing a nanoporous silicon nitride membrane comprising (i) ablating portions of at least one side of the membrane with an electron beam to reduce the thickness of the portions to between about 0.5 and 5 nanometers, and (ii) penetrating subportions of the ablated portions of the membrane with an electron beam to form nanopores having internal surfaces which are predominantly silicon rich compared to unablated portions of the membrane.
FILED	Thursday, September 17, 2015
APPL NO	15/511829
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Separation B01D 67/006 (20130101) Original (OR) Class B01D 71/02 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) G01N 33/48721 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/31 (20130101) H01J 37/317 (20130101) H01J 37/3056 (20130101) H01J 2237/3118 (20130101)
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11338290 — Sorting biological and non-biological moieties using magnetic levitation

US 11338290	Baday et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Human Genome Research Institute (NHGRI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Murat Baday (Menlo Park, California); Naside Gozde Durmus (Palo Alto, California); Semih Calamak (Palo Alto, California); Utkan Demirci (Stanford, California); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (San Francisco, California); Jaeyoung Yang (Palo Alto, California); Thiruppathiraja Chinnasamy (Mountain View, California); Alessandro Tocchio (San Francisco, California)
ABSTRACT	Systems and methods for levitating populations of moieties, cells, or other such units using one or more magnets in a microfluidic environment are provided. These systems and methods may be used to, for example, separate or sort heterogeneous populations of the units from one another, to assembly a multi-unit assembly during the levitating of the units, and to evaluate samples at the point of care in real-time. These systems and methods may also utilize a frame that enables an imaging device, such as a smartphone, to capture the units in real time as they are manipulated in the system.
FILED	Friday, September 30, 2016
APPL NO	15/764017
ART UNIT	1759 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/574 (20130101) G01N 33/4875 (20130101) G01N 33/54366 (20130101) G01N 33/56966 (20130101) G01N 2015/1486 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 2207/30101 (20130101) G06T 2207/30242 (20130101) G06T 2211/428 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101)
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11339122 — hTRPV1 chemical agents

US 11339122	Xie et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Xiang-Qun Xie (Sewickley, Pennsylvania); Zhiwei Feng (Pittsburgh, Pennsylvania)
ABSTRACT	Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.
FILED	Tuesday, November 24, 2020
APPL NO	17/103941
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 275/30 (20130101) Original (OR) Class C07C 275/32 (20130101) C07C 275/34 (20130101) C07C 275/40 (20130101) C07C 275/42 (20130101) Heterocyclic Compounds C07D 295/135 (20130101)
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11339140 — Compositions and methods comprising substituted 2-aminoimidazoles

US 11339140	Looper et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Curza Global, LLC (Provo, Utah); University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	Curza Global, LLC (Provo, Utah); The University of Utah (Salt Lake City, Utah)
INVENTOR(S)	Ryan E. Looper (Salt Lake City, Utah); Justin M. Salvant (Salt Lake City, Utah); Emily K. Kirkeby (Salt Lake City, Utah); Wenxing Guo (Salt Lake City, Utah); Katrin P. Guillen (Salt Lake City, Utah); Bryan E. Welm (Salt Lake City, Utah)
ABSTRACT	The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
FILED	Friday, September 27, 2019
APPL NO	16/586667
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 233/88 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 405/04 (20130101) C07D 487/04 (20130101)
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11339173 — Benzimidazoles and methods of using same

US 11339173	Davis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S)	Darrell Davis (Salt Lake City, Utah); Shuanghu Liu (Salt Lake City, Utah)
ABSTRACT	The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED	Wednesday, September 16, 2020
APPL NO	17/023323
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 235/30 (20130101) C07D 487/04 (20130101) C07D 491/048 (20130101) C07D 491/052 (20130101) C07D 491/147 (20130101) Original (OR) Class C07D 495/14 (20130101)
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11339178 — Inhibitors of microbial beta-glucuronidase enzymes and uses thereof

US 11339178	Redinbo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
INVENTOR(S)	Matthew R. Redinbo (Chapel Hill, North Carolina); Jian Jin (New York, New York); Lindsey James (Chapel Hill, North Carolina); Sam Pellock (Chapel Hill, North Carolina); Ranathunga Arachchillage Yamuna Ariyarathna (Carrboro, North Carolina); Stephen Frye (Chapel Hill, North Carolina)
ABSTRACT	Compounds and compositions are provided that comprise selective b-glucuronidase inhibitors. The compounds and compositions can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs.
FILED	Thursday, July 20, 2017
APPL NO	16/318991
ART UNIT	1627 — Organic Chemistry
CURRENT CPC	Heterocyclic Compounds C07D 513/14 (20130101) Original (OR) Class
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11339184 — Antibacterial compounds, compositions thereof, and methods using same

US 11339184	Brady et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Rockefeller University (New York, New York)
ASSIGNEE(S)	The Rockefeller University (New York, New York)
INVENTOR(S)	Sean F. Brady (New York, New York); James Peek (New York, New York)
ABSTRACT	The present disclosure includes novel compounds useful as antimicrobial agents. The present disclosure further includes methods useful. The present disclosure further includes compositions and methods for treating or preventing a bacterial infection. The present disclosure further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms.
FILED	Thursday, July 23, 2020
APPL NO	16/936900
ART UNIT	1623 — Organic Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 9/04 (20130101) Original (OR) Class
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11339190 — Peptides for the treatment of covid-19

US 11339190	Pahan
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Rush University Medical Center (Chicago, Illinois)
ASSIGNEE(S)	Rush University Medical Center (Chicago, Illinois)
INVENTOR(S)	Kalipada Pahan (Skokie, Illinois)
ABSTRACT	Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed.
FILED	Wednesday, December 23, 2020
APPL NO	17/133035
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101)
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11339192 — Bicyclic peptidyl inhibitors

US 11339192	Pei
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)	Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Dehua Pei (Columbus, Ohio)
ABSTRACT	The present disclosure provides a large combinatorial library of cell-permeable bicyclic peptides. The bicyclic peptides described herein include the first ring consisted of randomized peptide sequences for potential binding to a target of interest while the second ring featured a family of different cell-penetrating motifs, for both cell penetration and target binding. The library was screened against the IκB kinase α/β (IKKα/β)-binding domain of NF-κB essential modulator (NEMO), resulting in the discovery of several cell-permeable bicyclic peptides which inhibited the NEMO-IKKβ interaction, thereby selectively inhibiting canonical NF-κB signaling in mammalian cells and the proliferation of cisplatin-resistant ovarian cancer cells.
FILED	Thursday, October 04, 2018
APPL NO	16/753681
ART UNIT	1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class
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11339195 — Griffithsin mutants

US 11339195	O'Keefe et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S)	Barry R. O'Keefe (Frederick, Maryland); Tinoush Moulaei (College Park, Maryland); Kenneth E. Palmer (Owensboro, Kentucky); Lisa C. Rohan (Pittsburgh, Pennsylvania); Joshua L. Fuqua (Owensboro, Kentucky); Lindsay F. Kramzer (Pittsburgh, Pennsylvania)
ABSTRACT	The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
FILED	Wednesday, November 27, 2019
APPL NO	16/697685
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/16 (20130101) Peptides C07K 14/405 (20130101) Original (OR) Class
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11339198 — Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells

US 11339198	Felber et al.
FUNDED BY	Department of Health and Human Services (HHS)
APPLICANT(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland)
ASSIGNEE(S)	THE UNITED STATES OF AMERICA, AS REPRESENTED BY, THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Rockville, Maryland)
INVENTOR(S)	Barbara K. Felber (Rockville, Maryland); George N. Pavlakis (Rockville, Maryland)
ABSTRACT	The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence. The present invention further provides expression vectors, and IL-15 and IL 15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human).
FILED	Wednesday, August 21, 2019
APPL NO	16/547039
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/02 (20180101) Peptides C07K 14/535 (20130101) C07K 14/5443 (20130101) Original (OR) Class C07K 14/7155 (20130101) C07K 2319/02 (20130101)
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11339199 — Chimeric NK receptor and methods for treating cancer

US 11339199	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)	TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
INVENTOR(S)	Tong Zhang (Beijing, China PRC); Charles L. Sentman (West Lebanon, New Hampshire)
ABSTRACT	The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
FILED	Monday, July 01, 2019
APPL NO	16/458740
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 14/715 (20130101)
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11339219 — Checkpoint blockade and microsatellite instability

US 11339219	Diaz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)	The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S)	Luis Diaz (Ellicot City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookville, Maryland)
ABSTRACT	Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.
FILED	Tuesday, December 22, 2020
APPL NO	17/131328
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 2039/55 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/00 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101)
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11339223 — Methods of use of anti-Sortilin antibodies for treating a disease, disorder, or injury

US 11339223	Rosenthal et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	ALECTOR LLC (South San Francisco, California)
ASSIGNEE(S)	ALECTOR LLC (South San Francisco, California)
INVENTOR(S)	Arnon Rosenthal (Woodside, California); Tina Schwabe (San Francisco, California); Michael Kurnellas (San Francisco, California); Robert Pejchal (Lebanon, New Hampshire); Anthony B. Cooper (Lebanon, New Hampshire)
ABSTRACT	The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.
FILED	Wednesday, August 08, 2018
APPL NO	16/058817
ART UNIT	1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Peptides C07K 16/286 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/14 (20130101) C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2319/30 (20130101) C07K 2319/32 (20130101)
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11339267 — Green fabrication of polytetrafluoroethylene and expanded polytetrafluoroethylene and uses thereof

US 11339267	Turng et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S)	Lih-Sheng Turng (Madison, Wisconsin); Yiyang Xu (Madison, Wisconsin); Yu-Jyun Lin (Madison, Wisconsin); Dong-Fang Wang (Madison, Wisconsin)
ABSTRACT	Green, fast and easy evaporating organic solvent for use as a lubricant in the processing of polytetrafluoroethylene (PTFE) and expanded polytetrafluoroethylene (ePTFE) products and processes of using the solvents to fabricate the products are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts.
FILED	Thursday, January 16, 2020
APPL NO	16/744505
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/16 (20130101) A61L 27/56 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/092 (20130101) C08J 9/286 (20130101) Original (OR) Class C08J 2201/03 (20130101) C08J 2201/0502 (20130101) C08J 2327/18 (20130101)
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11339294 — Nanoprobe-metal chelator complexes

US 11339294	Choi et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts); Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts); Northeastern University (Boston, Massachusetts)
INVENTOR(S)	Hak Soo Choi (Needham, Massachusetts); Jonghan Kim (Cambridge, Massachusetts); Georges El Fakhri (Brookline, Massachusetts)
ABSTRACT	Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.
FILED	Monday, December 21, 2020
APPL NO	17/129380
ART UNIT	1626 — Organic Chemistry
CURRENT CPC	Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 23/0025 (20130101) C09B 23/0033 (20130101) C09B 23/0041 (20130101) C09B 23/0066 (20130101) Original (OR) Class C09B 69/105 (20130101)
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11339362 — Organ chip to model mammalian joint

US 11339362	Lin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Hang Lin (Pittsburgh, Pennsylvania); Peter Alexander (Wexford, Pennsylvania); Riccardo Lucca Gottardi (Pittsburgh, Pennsylvania); Rocky Sung Chi Tuan (Pittsburgh, Pennsylvania)
ABSTRACT	Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system. In some cases, the system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate.
FILED	Friday, November 16, 2018
APPL NO	16/193972
ART UNIT	1799 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/3834 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/10 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 35/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) C12N 2502/28 (20130101) C12N 2502/1311 (20130101) C12N 2533/54 (20130101)
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11339365 — Nanopore sensor for enzyme-mediated protein translocation

US 11339365	Nivala et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	Jeffrey Matthew Nivala (Santa Cruz, California); Douglas Benjamin Marks (Santa Cruz, California); Mark Albert Akeson (Santa Cruz, California)
ABSTRACT	Described herein is a device and method for translocating a protein through a nanopore and monitoring electronic changes caused by different amino acids in the protein. The device comprises a nanopore in a membrane, an amplifier for providing a voltage between the cis side and trans side of the membrane, and an NTP driven unfoldase which processed the protein to be translocated. The exemplified unfoldase is the ClpX unfoldase from E. coli.
FILED	Friday, February 15, 2013
APPL NO	14/378448
ART UNIT	1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 47/06 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) G01N 33/54366 (20130101)
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11339375 — Paramyxovirus virus-like particles as protein delivery vehicles

US 11339375	Schmitt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Anthony Paul Schmitt (State College, Pennsylvania); Phuong Tieu Schmitt (State College, Pennsylvania); Greeshma Vivekananda Ray (Cleveland, Ohio)
ABSTRACT	Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting VLPs, and methods for screening for anti-viral compounds using the VLPs. The modified VLPs contain a contiguous recombinant polypeptide that contains i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein. Non-covalent complexes of paramyxovirus M protein and fusion proteins that contain a C-terminal domain of a paramyxovirus nucleocapsid protein and a polypeptide sequence of a distinct protein are provided, as are non-covalent complexes of cells, and cell receptors, with modified VLPs.
FILED	Thursday, June 06, 2019
APPL NO	16/433412
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/005 (20130101) C07K 14/8121 (20130101) C07K 16/1027 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 9/0069 (20130101) C12N 9/0089 (20130101) C12N 2760/18022 (20130101) C12N 2760/18023 (20130101) C12N 2760/18034 (20130101) C12N 2760/18222 (20130101) C12N 2760/18223 (20130101) C12N 2760/18234 (20130101) C12N 2760/18252 (20130101) C12N 2760/18722 (20130101) C12N 2760/18723 (20130101) C12N 2760/18734 (20130101) Enzymes C12Y 113/12005 (20130101) C12Y 115/01001 (20130101)
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11339378 — Non-neuroinvasive viruses and uses thereof

US 11339378	Smith et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) NIH Office of the Director (NIHOD)
APPLICANT(S)	Northwestern University (Evanston, Illinois); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Trustees of Tufts College (Medford, Massachusetts)
INVENTOR(S)	Gregory A. Smith (Oak Park, Illinois); Patricia Jane Sollars (Lincoln, Nebraska); Gary Edward Pickard (Lincoln, Nebraska); Ekaterina E. Heldwein (Belmont, Massachusetts)
ABSTRACT	Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
FILED	Wednesday, May 06, 2020
APPL NO	16/868246
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) A61K 39/12 (20130101) A61K 39/25 (20130101) A61K 39/245 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) C07K 2299/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2710/16034 (20130101) C12N 2710/16621 (20130101) C12N 2710/16622 (20130101) C12N 2710/16632 (20130101) C12N 2710/16633 (20130101) C12N 2710/16634 (20130101) C12N 2710/16643 (20130101) C12N 2710/16721 (20130101) C12N 2710/16722 (20130101) C12N 2710/16732 (20130101) C12N 2710/16733 (20130101) C12N 2710/16734 (20130101) C12N 2710/16743 (20130101)
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11339390 — DNA microscopy methods

US 11339390	Zhang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Mental Health (NIMH)
APPLICANT(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)	THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Feng Zhang (Cambridge, Massachusetts); Joshua Asher Weinstein (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts)
ABSTRACT	The present invention relates to DNA microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with nucleic sequences. The method involves sequence-components which may identify the targeted sequences-of-interest themselves and/or spatial beacons relative to which their distances are measured.
FILED	Friday, September 09, 2016
APPL NO	15/554627
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class C12N 15/1065 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6841 (20130101) C12Q 1/6841 (20130101) C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2535/122 (20130101) C12Q 2537/165 (20130101) C12Q 2537/165 (20130101) C12Q 2543/101 (20130101) C12Q 2543/101 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) C12Q 2565/514 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/5082 (20130101)
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11339392 — Pan-genotypic agents against influenza virus and methods of using the same

US 11339392	Glenn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Jeffrey S. Glenn (Palo Alto, California); Rachel Hagey Saluti (Stanford, California); Edward A. Pham (Palo Alto, California)
ABSTRACT	Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.
FILED	Friday, February 14, 2020
APPL NO	16/792103
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 2310/31 (20130101) C12N 2310/322 (20130101) C12N 2310/531 (20130101) C12N 2310/3231 (20130101)
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11339395 — RNA-based regulatory technologies for miRNA sensors

US 11339395	Weiss et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Ron Weiss (Newton, Massachusetts); Kevin J. Lebo (Weymouth, Massachusetts); Jin Huh (Watertown, Massachusetts)
ABSTRACT	Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. In some embodiments, the cell state classifiers described herein utilize an endoribonuclease and a self-amplifying RNA molecule for controlling the expression of an output molecule. In some embodiments, the cell state classifiers described herein are encoded on a single RNA transcript, which is then processed to produce individual genetic circuits that function independently. The genetic circuits and cell state classifiers described herein may be used in various applications (e.g., therapeutic or diagnostic applications).
FILED	Thursday, August 01, 2019
APPL NO	16/528697
ART UNIT	1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/85 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2800/80 (20130101)
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11339396 — Engineered viral vector reduces induction of inflammatory and immune responses

US 11339396	Chan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)	President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S)	Ying Kai Chan (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts)
ABSTRACT	Modified viral genomes are able to reduce induction of inflammatory and immune anti-viral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and increased expression of transgenes. Viral genomes are modified by incorporating one or more oligonucleotide sequences which are able to bind to TLR9 but not induce activation of it. The oligonucleotide sequences may be synthetic, bacterial, human, or from any other source.
FILED	Thursday, June 08, 2017
APPL NO	16/308420
ART UNIT	1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 35/76 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/117 (20130101) Original (OR) Class C12N 2310/17 (20130101) C12N 2330/51 (20130101) C12N 2750/00032 (20130101) C12N 2750/00041 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) C12N 2750/14171 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101)
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11339420 — Fluorescence-based reporters for mutagenesis detection in E. coli

US 11339420	Camps et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Manel Camps (Santa Cruz, California); Jennifer Allen (Santa Cruz, California)
ABSTRACT	Direct detection of mutagenesis in prokaryotes by reversion of an inactivating mutation (reversion mutation assay), producing a quantitative signal for in vivo mutagenesis, may greatly reduce the amount of test chemicals and labor involved in these assays. Further, transcriptional coupling of β-lactamase reversion and GFP, translational fusion between β-lactamase and GFP with stop codon in GFP, and a novel dual reporter to monitor continuous mutagenesis may be used in methods described herein.
FILED	Tuesday, December 26, 2017
APPL NO	16/473442
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/86 (20130101) C12N 15/72 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Original (OR) Class Enzymes C12Y 305/02006 (20130101)
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11339432 — Nucleic acid constructs and methods of use

US 11339432	Chee
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S)	Mark S. Chee (Encinitas, California)
ABSTRACT	The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.
FILED	Thursday, April 22, 2021
APPL NO	17/237962
ART UNIT	1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6827 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6834 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6874 (20130101) C12Q 1/6876 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/131 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2525/155 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2539/103 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/149 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101)
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11339436 — Methods for early identification of bone healing ability in injured patients

US 11339436	Horan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
INVENTOR(S)	Annamarie D. Horan (Philadelphia, Pennsylvania); Samir Mehta (Haddonfield, New Jersey); Donald A. Baldwin (Newtown Square, Pennsylvania)
ABSTRACT	The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. The invention further includes a kit comprising biomarker probes for assessing the bone healing ability in an acutely injured subject or in a nonunion subject after receiving therapeutic treatment.
FILED	Wednesday, February 03, 2016
APPL NO	15/548535
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/6887 (20130101) G01N 33/6893 (20130101) G01N 2570/00 (20130101) G01N 2800/10 (20130101)
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11339441 — Profiling chemically modified DNA/RNA units for disease and cancer diagnosis

US 11339441	Rose et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Research Foundation for The State University of New York (Albany, Massachusetts)
ASSIGNEE(S)	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York)
INVENTOR(S)	Rebecca Rose (Albany, New York); Daniele Fabris (Clifton Park, New York)
ABSTRACT	The present invention relates to high-throughput methods comprising direct infusion electrospray ionization mass spectrometry (ESI-MS), multistep tandem mass spectrometry (MSⁿ), consecutive reaction monitoring (CRM), ion mobility spectrometry mass spectrometry (IMS-MS), high-resolution MS, and IMS-MS, for genome-wide (whole cell or tissue) profiling of DNA and RNA nucleotides/nucleosides having a wide variety of variant structural modifications. In particular, these methods are contemplated for providing a specific profile of variant DNA and/or RNA chemically modified nucleic acids (i.e. structures) associated with specific medical conditions. Medical conditions may include, but are not limited to: cancer; including prostate, lung, uterus, larynx, ovary, breast, kidney, and many other types of cancers; specific stages of cancer; bacterial infections; viral infections; genetic and metabolic disorders; and any condition involving changes in DNA and/or RNA structural modifications.
FILED	Thursday, May 12, 2016
APPL NO	15/152996
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/68 (20130101) C12Q 1/6872 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2565/627 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0036 (20130101)
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11339442 — Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof

US 11339442	Bernstein et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI)
APPLICANT(S)	THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts)
ASSIGNEE(S)	The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S)	Bradley Bernstein (Cambridge, Massachusetts); Yotam Drier (Cambridge, Massachusetts); William Flavahan (Malden, Massachusetts); Daniel Tarjan (Cambridge, Massachusetts)
ABSTRACT	The present application generally to the diagnosis and treatment of diseases resulting from the alteration of chromatin boundaries between topologically-associated domains. In particular, the present application relates to detection of mutations causing DNA hypermethylation phenotypes, CpG methylation within CTCF binding motifs, and aberrant gene expression caused by altered chromatin topology. Applicants show that IDH mutant gliomas exhibit hyper-methylation at CTCF binding sites, compromising binding of this methylation-sensitive insulator protein. Applicants also demonstrate that loss of CTCF at a domain boundary permits a constitutive enhancer to aberrantly interact with the receptor tyrosine kinase gene PDGFRA, a prominent glioma oncogene. Thus, Applicants have uncovered that IDH mutations may promote gliomagenesis by disrupting chromosomal topology and allowing aberrant regulatory interactions that induce oncogene expression.
FILED	Wednesday, December 14, 2016
APPL NO	16/061546
ART UNIT	1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101)
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11340174 — Screening test for caries activity and caries risk assessmbased on the combined production of acid and alkali in the oral cavity (acid-base caries test: abc-test)

US 11340174	Morou-Bermudez
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	Evangelia Morou-Bermudez (San Juan, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Evangelia Morou-Bermudez (San Juan, Puerto Rico)
ABSTRACT	Effective monitoring of the acid/base physiology of dental plaque is considered in caries risk assessment. The invention provides a methodology for caries risk assessment and a kit of biochemical tests for acid/alkali generation in dental plaque and in saliva as a screening instrument for identifying subjects with caries. The invention provides simple chair-side tests that measure the ability of dental plaque and/or saliva to metabolize sugars concomitantly with the ability to metabolize urea and other salivary nitrogenous substrates.
FILED	Monday, February 13, 2017
APPL NO	15/431743
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/80 (20130101) Original (OR) Class G01N 33/48 (20130101) G01N 33/52 (20130101) G01N 2800/18 (20130101)
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11340200 — Electrospray assisted capillary device for processing ultra low-volume samples

US 11340200	Wu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Board of Regents of the University of Oklahoma (Oklahoma City, Oklahoma)
ASSIGNEE(S)	The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
INVENTOR(S)	Si Wu (Norman, Oklahoma); Lushuang Huang (Norman, Oklahoma); Zhe Wang (San Francisco, California)
ABSTRACT	A spray-capillary device is configured to process ultra low-volume samples. The spray-capillary device includes a spray capillary that includes an inlet end and a discharge end. The spray capillary includes a porous section at the discharge end. A downstream connector provides an interface between the porous section of the spray capillary, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra law volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the spray capillary to encourage movement of the sample through the spray capillary. The spray-capillary device is well suited for providing ultra low samples to a mass spectrometer detection device.
FILED	Monday, March 08, 2021
APPL NO	17/194539
ART UNIT	2881 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/7266 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/167 (20130101)
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11340216 — Methods and compositions for the positive selection of protein destabilizers

US 11340216	Kaelin et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)	Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S)	William G. Kaelin (Boston, Massachusetts); Vidyasagar Koduri (Brookline, Massachusetts)
ABSTRACT	The present application relates, in some aspects, to the development of an assay that uses cell survival and/or cell viability as a phenotypic identifier to positively select for agents that destabilize a protein of interest.
FILED	Wednesday, September 13, 2017
APPL NO	16/332921
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Peptides C07K 14/00 (20130101) C07K 14/435 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1211 (20130101) C12N 9/1229 (20130101) C12N 9/1241 (20130101) C12N 9/6472 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) Original (OR) Class G01N 2500/10 (20130101) G01N 2510/00 (20130101)
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11340219 — Anti-pY1235-MET immunological binding reagent

US 11340219	Srivastava et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) Frederick National Laboratory for Cancer Research (FNLCR) Federally Funded Research and Development Center (FFRDC) Operated by Leidos Biomedical Research, Inc. (LBRI) at Frederick, MD
APPLICANT(S)	THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (Rockville, Maryland)
ASSIGNEE(S)	The United States Of America, As Represented by the Secretary, Department Of Health And Human Services (Bethesda, Maryland)
INVENTOR(S)	Apurva K. Srivastava (Rockville, Maryland); Thomas D. Pfister (Rockville, Maryland); Tony Navas (Rockville, Maryland); Ralph E. Parchment (Rockville, Maryland); James E. Doroshow (Rockville, Maryland)
ABSTRACT	Methods and compositions are described herein for assaying the presence or absence of pY1235-MET or a fragment thereof.
FILED	Thursday, March 16, 2017
APPL NO	16/085999
ART UNIT	1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/44 (20130101) C07K 2317/565 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) Original (OR) Class G01N 2333/705 (20130101) G01N 2800/52 (20130101)
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11340227 — Methods and compounds for diagnosing threonyl-tRNA synthetase-associated diseases and conditions

US 11340227	Francklyn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S)	The University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)	University of Vermont and State Agricultural College (Burlington, Vermont)
INVENTOR(S)	Christopher Francklyn (Burlington, Vermont); Karen M. Lounsbury (Essex Junction, Vermont); Tamara Williams (South Burlington, Vermont)
ABSTRACT	The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.
FILED	Wednesday, November 28, 2018
APPL NO	16/202884
ART UNIT	1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/25 (20130101) C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 33/57496 (20130101) G01N 2333/9015 (20130101) G01N 2800/52 (20130101) G01N 2800/7014 (20130101)
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11340232 — Peptide constructs and assay systems

US 11340232	Kozlov et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Prognosys Biosciences, Inc. (San Diego, California)
ASSIGNEE(S)	Prognosys Biosciences, Inc. (San Diego, California)
INVENTOR(S)	Igor A. Kozlov (San Diego, California); Mark S. Chee (San Diego, California); Petr Capek (San Diego, California); David A. Routenberg (San Diego, California)
ABSTRACT	The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.
FILED	Monday, April 30, 2018
APPL NO	15/967461
ART UNIT	1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1062 (20130101) C12N 15/1062 (20130101) C12N 15/1075 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2521/537 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6803 (20130101) Original (OR) Class
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11340325 — Diffusion-weighted double-echo magnetic resonance fingerprinting (MRF)

US 11340325	Griswold et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)	Case Western Reserve University (Cleveland, Ohio)
INVENTOR(S)	Mark Griswold (Shaker Heights, Ohio); Vikas Gulani (Shaker Heights, Ohio); Dan Ma (Cleveland Heights, Ohio); Yun Jiang (Cleveland Heights, Ohio); Katherine Wright (Macedonia, Ohio)
ABSTRACT	Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. Sampling is performed in response to a diffusion-weighted double-echo pulse sequence. Sampling acquires transient-state signals of the double-echo sequence. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals.
FILED	Monday, May 06, 2019
APPL NO	16/404657
ART UNIT	2896 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4828 (20130101) G01R 33/5608 (20130101) Original (OR) Class G01R 33/56341 (20130101)
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11340878 — Interative gallery of user-selectable digital health programs

US 11340878	Jain et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Vignet Incorporated (Fairfax, Virginia)
ASSIGNEE(S)	VigNet Incorporated (Fairfax, Virginia)
INVENTOR(S)	Praduman Jain (Fairfax, Virginia); Dave Klein (Oakton, Virginia); Neeta Jain (Fairfax, Virginia); Yue Cao (Vienna, Virginia)
ABSTRACT	In some implementations, a user interface for designing a health management module is provided by a server system. The user interface identifies a plurality of health management templates. The server system initially receives data indicating a user input received through the user interface that selects one of the plurality of module templates. The server system also receives customization parameters that customize the selected module template for a particular organization. The server system then generates a customized health management module for the particular organization based on the selected template and the customization parameters. The server system finally publishes the customized health management module for the particular organization that includes instructions configuring an application provided by a third-party application store.
FILED	Monday, May 18, 2020
APPL NO	16/877187
ART UNIT	2192 — Interprocess Communication and Software Development
CURRENT CPC	Electric Digital Data Processing G06F 3/04817 (20130101) G06F 3/04842 (20130101) G06F 8/38 (20130101) G06F 8/60 (20130101) Original (OR) Class G06F 8/61 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 40/40 (20180101) G16H 40/63 (20180101) G16H 40/67 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0803 (20130101) H04L 67/06 (20130101) H04L 67/20 (20130101) H04L 67/025 (20130101) H04L 67/34 (20130101) H04L 67/42 (20130101) H04L 67/125 (20130101)
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11341649 — Systems and methods for quantifying multiscale competitive landscapes of clonal diversity in glioblastoma

US 11341649	Hu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Mayo Foundation for Medical Education and Research (Rochester, Minnesota); Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona)
ASSIGNEE(S)	Mayo Foundation for Medical Education and Research (Rochester, Maine); Arizona Board of Regents (Scottsdale, Arizona)
INVENTOR(S)	Leland S. Hu (Phoenix, Arizona); Kristin R. Swanson (Phoenix, Arizona); J. Ross Mitchell (Scottsdale, Arizona); Nhan L. Tran (Peoria, Arizona); Jing Li (Tempe, Arizona); Teresa Wu (Gilbert, Arizona)
ABSTRACT	Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.
FILED	Tuesday, February 26, 2019
APPL NO	16/975647
ART UNIT	2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0016 (20130101) Original (OR) Class G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101)
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11342051 — Infectious disease monitoring using location information and surveys

US 11342051	Jain et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Vignet Incorporated (Fairfax, Virginia)
ASSIGNEE(S)	VigNet Incorporated (Fairfax, Virginia)
INVENTOR(S)	Praduman Jain (Fairfax, Virginia); Josh Schilling (Salem, Oregon); Dave Klein (Oakton, Virginia)
ABSTRACT	Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for automated contact tracing using multiple data sources. In some implementations, a system uses location data generated based on one or more types of signals, such as GPS signals, WI-FI signals, signals from cellular base stations, signals from short-range wireless technology (e.g., BLUETOOTH), and so on. The system also prompts users for information regarding their locations and the conditions present at the locations, either at the time a user is present or later. With this information, the system compares the tracked locations for different individuals to identify instances of contacts in which criteria for disease transmission potential are met, e.g., when two individuals have certain levels of proximity and timing. Detected instances of contacts can be used to inform individuals of exposure to a disease, as well as to notify public health authorities.
FILED	Friday, August 21, 2020
APPL NO	17/000114
ART UNIT	2689 — Signal Processing and Control Processing in Disk Drives
CURRENT CPC	Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) Original (OR) Class G16H 10/60 (20180101) G16H 40/67 (20180101) Wireless Communication Networks H04W 4/029 (20180201) H04W 4/80 (20180201) H04W 64/003 (20130101)
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Department of Defense (DOD)

11337485 — Wearable planetary gear configuration

US 11337485	Sharpes
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Nathan Sharpes (Abingdon, Maryland)
ABSTRACT	A wearable system, such as a footwear system, can employ a generator. The generator can be powered by human movement, such as movement of knee as a person walks or runs. When the knee resets, it can be desirable to have a relatively equal gear ratio to achieve near natural movement. Conversely, it can be desirable to have a high gear ratio when the knee pushes off to achieve high generator rotation to produce a high amount of power. This can be achieved with employment of a wearable planetary gear set configuration In practicing this wearable planetary gear set, torque can be provided from the source (e.g. human ankle joint) when power negative and not at other times during a movement cycle, meaning energy can be harvested from the walking motion without inducing additional burden to the device wearer.
FILED	Monday, August 26, 2019
APPL NO	16/550333
ART UNIT	3655 — Material and Article Handling
CURRENT CPC	Outerwear; Protective Garments; Accessories A41D 1/002 (20130101) Characteristic Features of Footwear; Parts of Footwear A43B 3/0015 (20130101) Original (OR) Class A43B 21/24 (20130101) A43B 21/30 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 41/00 (20130101) F16D 67/02 (20130101) Gearing F16H 3/44 (20130101) F16H 57/10 (20130101) F16H 2200/20 (20130101) F16H 2200/0034 (20130101) F16H 2200/2005 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/00032 (20200101) H02J 7/32 (20130101) Dynamo-electric Machines H02K 7/112 (20130101) H02K 7/116 (20130101) H02K 7/1853 (20130101)
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11337665 — Radiographic contrast agents for temporal subtraction and dual-energy x-ray imaging

US 11337665	Maidment et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Andrew D. A. Maidment (Villanova, Pennsylvania); Anatoliy V. Popov (Philadelphia, Pennsylvania); E. James Delikatny (Havertown, Pennsylvania); Andrew Tsourkas (Bryn Mawr, Pennsylvania); Roshan Karunamuni (Philadelphia, Pennsylvania); Ajlan Al Zaki (Philadelphia, Pennsylvania); Sara Gavenonis (Wilmington, Delaware); David Cormode (Philadelphia, Pennsylvania)
ABSTRACT	Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.
FILED	Thursday, March 13, 2014
APPL NO	14/776232
ART UNIT	1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/481 (20130101) Original (OR) Class A61B 6/482 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/32 (20130101) A61K 49/04 (20130101) A61K 49/0423 (20130101)
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11338025 — Vaccine therapy for treatment of endometrial and ovarian cancer

US 11338025	Peoples
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
INVENTOR(S)	George E. Peoples (Spring Branch, Texas)
ABSTRACT	The present invention provides methods of preventing or reducing the risk of recurrence of endometrial and ovarian cancers which express low levels of folate binding protein (FBP) by administration of a vaccine containing an E39 peptide.
FILED	Tuesday, January 16, 2018
APPL NO	15/872626
ART UNIT	1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/545 (20130101) A61K 2039/585 (20130101) A61K 2039/55516 (20130101) A61K 2039/55522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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11338037 — Ultrastable antibody ionic liquids

US 11338037	Slocik et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Joseph M Slocik (Dayton, Ohio); Rajesh R. Naik (Centerville, Ohio); Patrick B Dennis (Cincinnati, Ohio)
ABSTRACT	A method for creating a stable protein/antibody ionic liquid, comprising: (a) cationizing aqueous proteins/antibodies by addition of an excess of a positively-charged crosslinker in the presence of a coupling reagent; (b) purifying the cationized proteins/antibodies; (c) titrating the cationized proteins/antibodies with a corresponding biologically-compatible counter anionic polymer to create at least one protein/antibody cation/anion pair in aqueous solution until the cation/anion pair solution becomes negative by zeta potential measurement; (d) repeatedly dialyzing the protein/antibody cation/anion pair in water to remove excess anionic polymer using at least one molecular weight cutoff 7000 dialysis membrane; (e) lyophilizing the protein/antibody cation/anion pair to remove most of the water, forming a lyophilized solid; and (f) heating the lyophilized solid until a protein/antibody ionic liquid is generated. The antibody may be any desired antibody, and the anion may be any biologically-compatible anion.
FILED	Friday, October 04, 2019
APPL NO	16/592809
ART UNIT	1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 39/39591 (20130101) Original (OR) Class Peptides C07K 1/10 (20130101) C07K 1/36 (20130101) C07K 16/00 (20130101) C07K 16/34 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/531 (20130101)
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11338056 — Microfluidic extrusion

US 11338056	Francis et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Embody, Inc. (Norfolk, Virginia)
ASSIGNEE(S)	EMBODY, INC. (Norfolk, Virginia)
INVENTOR(S)	Michael P. Francis (Norfolk, Virginia); Stella Petrova (Blacksburg, Virginia); Nicholas Thayer (Morrisville, North Carolina)
ABSTRACT	A method for supporting repair of soft tissue with biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. The fibers are used to support repair of soft tissue.
FILED	Monday, May 24, 2021
APPL NO	17/328633
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 17/14 (20130101) A61L 17/105 (20130101) A61L 27/24 (20130101) Original (OR) Class A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2430/10 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/02 (20130101) D01D 5/06 (20130101) D01D 5/38 (20130101) D01D 7/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101)
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11338057 — Microfluidic extrusion

US 11338057	Francis et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Embody, Inc. (Norfolk, Virginia)
ASSIGNEE(S)	Embody, LLC (Norfolk, Virginia)
INVENTOR(S)	Michael P. Francis (Norfolk, Virginia); Stella Petrova (Blacksburg, Virginia); Nicholas Thayer (Morrisville, North Carolina)
ABSTRACT	Implantable scaffolds made from biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. Scaffolds then are made.
FILED	Monday, May 24, 2021
APPL NO	17/328854
ART UNIT	1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 17/14 (20130101) A61L 17/105 (20130101) A61L 27/24 (20130101) Original (OR) Class A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2430/10 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/02 (20130101) D01D 5/06 (20130101) D01D 5/38 (20130101) D01D 7/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101)
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11338087 — Hierarchical adaptive closed-loop fluid resuscitation and cardiovascular drug administration system

US 11338087	Gholami
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Autonomous Healthcare, Inc. (Hoboken, New Jersey)
ASSIGNEE(S)	Autonomous Healthcare, Inc. (Hoboken, New Jersey)
INVENTOR(S)	Behnood Gholami (Hoboken, New Jersey)
ABSTRACT	The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.
FILED	Thursday, November 05, 2020
APPL NO	17/090729
ART UNIT	3686 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3569 (20130101) A61M 2230/00 (20130101) A61M 2230/06 (20130101) A61M 2230/30 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/63 (20180101)
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11338890 — Line cutter apparatus

US 11338890	Bomback et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Lucas A Bomback (Swansea, Massachusetts); Bryan B Bohn (Newport, Rhode Island)
ABSTRACT	A line-cutter apparatus capable of being mounted on a tow cable is provided. A body is formed from two releasably coupled housings having a central bore when combined. A plurality of longitudinal grooves are formed in the body that divide the body into a respective plurality of longitudinal segments. Guard portions on the body correspond to the longitudinal segments. The body has fin portions that correspond to the longitudinal segments. Blades corresponding to the segments are received within the body and have a cutting edge that protrudes into one respective passageway of a longitudinal segment.
FILED	Wednesday, September 09, 2020
APPL NO	17/015164
ART UNIT	3617 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Ships or Other Waterborne Vessels; Equipment for Shipping B63B 21/66 (20130101) Original (OR) Class
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11338943 — Concurrent rocket engine pre-conditioning and tank loading

US 11338943	Swenson et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)	The Boeing Company (Chicago, Illinois)
INVENTOR(S)	Kevin Swenson (Long Beach, California); Henry Rodriguez, Jr. (Diamond Bar, California); Brian Vaniman (Fountain Valley, California); Martin Edward Lozano (Whittier, California)
ABSTRACT	Concurrent rocket engine pre-conditioning and tank filling is disclosed. A disclosed example apparatus includes an inlet valve to supply a rocket propellant tank that is associated with a rocket engine with rocket propellant, and a flow director to direct at least a portion of a flow of the rocket propellant from the inlet valve to a chill line of the rocket engine to thermally condition the rocket engine as the rocket propellant tank is being filled with the rocket propellant.
FILED	Friday, October 05, 2018
APPL NO	16/153435
ART UNIT	3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/002 (20130101) B64G 1/401 (20130101) B64G 1/402 (20130101) Original (OR) Class B64G 5/00 (20130101) Jet-propulsion Plants F02K 9/58 (20130101) F02K 9/566 (20130101) F02K 9/605 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2260/606 (20130101) F05D 2270/306 (20130101)
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11339097 — Refractory metal silicide nanoparticle ceramics

US 11339097	Keller et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Teddy M. Keller (Fairfax Station, Virginia); Matthew Laskoski (Springfield, Virginia)
ABSTRACT	Particles of a refractory metal or a refractory-metal compound capable of decomposing or reacting into refractory-metal nanoparticles, elemental silicon, and an organic compound having a char yield of at least 60% by weight are combined to form a precursor mixture. The mixture is heating, forming a thermoset and/or metal nanoparticles. Further heating form a composition having nanoparticles of a refractory-metal silicide and a carbonaceous matrix. The composition is not in the form of a powder
FILED	Tuesday, December 11, 2018
APPL NO	16/216279
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/52 (20130101) C04B 35/65 (20130101) C04B 35/78 (20130101) C04B 35/573 (20130101) C04B 35/6261 (20130101) C04B 35/58092 (20130101) Original (OR) Class C04B 2235/44 (20130101) C04B 2235/48 (20130101) C04B 2235/95 (20130101) C04B 2235/422 (20130101) C04B 2235/428 (20130101) C04B 2235/602 (20130101) C04B 2235/661 (20130101) C04B 2235/781 (20130101) C04B 2235/3232 (20130101) C04B 2235/3239 (20130101) C04B 2235/3244 (20130101) C04B 2235/3251 (20130101) C04B 2235/3256 (20130101) C04B 2235/3258 (20130101) C04B 2235/3826 (20130101) C04B 2235/3839 (20130101) C04B 2235/3843 (20130101) C04B 2235/3886 (20130101) C04B 2235/3891 (20130101) C04B 2235/5436 (20130101) C04B 2235/5454 (20130101) C04B 2235/6562 (20130101) C04B 2235/6567 (20130101) C04B 2235/6586 (20130101)
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11339208 — Camelidae single-domain antibodies against Yersinia pestis and methods of use

US 11339208	Mauzy et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S)	Camilla A Mauzy (Enon, Ohio); Serge Victor Marie Muyldermans (Brussels, Belgium)
ABSTRACT	Single-domain antibodies (SAbs) against three Yersinia pestis surface proteins (LcrV, YscF, and F1), nucleic acid sequences encoding the SAbs, and polypeptides comprising two or more SAbs capable of recognizing two or more epitopes and/or antigens. The present invention further includes methods for preventing or treating Y. pestis infections in a patient; methods for detecting and/or diagnosing Y. pestis infections; and devices and methods for identifying and/or detecting Y. pestis on a surface and/or in an environment.
FILED	Friday, June 29, 2018
APPL NO	16/023723
ART UNIT	1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 16/1228 (20130101) Original (OR) Class
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11339361 — Additive manufacturing of functional myocardial tissue

US 11339361	Zhang et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Space and Naval Warfare Systems Center (SPAWAR)
APPLICANT(S)	The United States of America, as Represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Yu Shrike Zhang (Cambridge, Massachusetts); Ali Khademhosseini (Los Angeles, California)
ABSTRACT	A bioreactor and methods for use can include a microfibrous scaffold, that can be made of a composite bioink, and that can have endothelial cells directly embedded within the scaffold using an additive manufacturing process. The scaffold can further be seeded with cardiomyocytes. The hydrogel scaffold can be composed of a plurality of serpentine layers, with each serpentine layers, which can be placed on each other in a cross-hatch configuration, so that the primary axes of successive layers are perpendicular. This configuration can establish an aspect ratio for the scaffold, which can be selectively varied. For greater strength, the successive layers that have a primary axis in the same direction can be placed in the scaffold so that they are slight offset from each other. The scaffold can be placed in the bioreactor with perfusion, for use in cardiovascular drug screening and other nanomedicine endeavors.
FILED	Friday, August 31, 2018
APPL NO	16/119022
ART UNIT	1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 25/14 (20130101) C12M 35/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) C12N 5/0607 (20130101) C12N 5/0657 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5061 (20130101) G01N 33/5064 (20130101) G01N 33/5088 (20130101)
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11339413 — Compositions and methods for robust dynamic metabolic control of 3-hydroxypropionic acid production

US 11339413	Lynch et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S)	Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina)
ABSTRACT	The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network.
FILED	Wednesday, October 23, 2019
APPL NO	16/661085
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101)
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11339722 — Air seal interface with AFT engagement features and active clearance control for a gas turbine engine

US 11339722	McCaffrey
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S)	Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S)	Michael G. McCaffrey (Windsor, Connecticut)
ABSTRACT	An interface for a gas turbine engine. The interface includes a full-hoop vane ring around the engine axis, the full-hoop vane ring comprises a forward vane rail with a vane ring forward contact surface and a vane ring anti-rotation tab, the vane ring anti-rotation tab engaged with the anti-rotation case slot; and a multiple of BOAS segments around the engine axis, each of the multiple of BOAS segments comprise a BOAS aft engagement feature and a BOAS aft contact surface, the BOAS aft engagement feature engaged with the outer case and the anti-rotation case slot, the BOAS aft contact surface abuts the vane ring forward contact surface.
FILED	Wednesday, February 10, 2021
APPL NO	17/172858
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/122 (20130101) F01D 25/24 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/55 (20130101) F05D 2260/30 (20130101)
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11340057 — Systems and methods for interferometric multifocus microscopy

US 11340057	He et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Kuan He (Cupertino, California); Oliver Strider Cossairt (Evanston, Illinois); Aggelos K. Katsaggelos (Chicago, Illinois); Norbert Scherer (Chicago, Illinois); Mark Hereld (Chicago, Illinois)
ABSTRACT	A system to generate image representations includes a first objective that receives a first light beam emitted from a sample and a second objective that receives a second light beam emitted from the sample, where the first light beam and the second light beam have conjugate phase. The system also includes a first diffractive element to receive the first light beam and separate it into a first plurality of diffractive light beams that are spatially distinct, and a second diffractive element to receive the second light beam and separate it into a second plurality of diffractive light beams that are spatially distinct. The system further includes a detector that receives the first and second plurality of diffractive light beams. The first plurality of diffractive light beams and the second plurality of diffractive light beams are simultaneously directed and focused onto different portions of an image plane of the detector.
FILED	Friday, June 21, 2019
APPL NO	15/734172
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/04 (20130101) Original (OR) Class G01B 9/02041 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4788 (20130101) Optical Elements, Systems, or Apparatus G02B 21/361 (20130101)
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11340112 — Reflective relay spectrometer

US 11340112	Mitchell
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Wavefront Research, Inc. (Northampton, Pennsylvania)
ASSIGNEE(S)	Wavefront Research, Inc. (Northhampton, Pennsylvania)
INVENTOR(S)	Thomas A. Mitchell (Northampton, Pennsylvania)
ABSTRACT	A reflective relay spectrometer design based on reflective optical relay systems, which is more compact in physical size and superior in spectral imaging quality than previous designs, is disclosed.
FILED	Friday, July 17, 2020
APPL NO	16/932358
ART UNIT	2877 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/18 (20130101) Original (OR) Class G01J 3/0205 (20130101) G01J 3/2823 (20130101) G01J 2003/1861 (20130101)
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11340179 — Nanofabricated structures for sub-beam resolution and spectral enhancement in tomographic imaging

US 11340179	Lavely et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic System Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Eugene M. Lavely (Concord, Massachusetts); Amrita V. Masurkar (Burlington, Massachusetts); Thomas J. Stark (Manchester, New Hampshire)
ABSTRACT	Techniques are provided for tomographic imaging with sub-beam resolution and spectral enhancement. A system implementing the techniques according to an embodiment includes a target structure comprising one or more selected materials nanopatterned on a first surface of the target structure in a selected arrangement. The system also includes a primary particle beam source to provide a particle beam incident on an area of the first surface of the target structure, the area encompassing one or more of the nanopatterned materials, such that the materials generate characteristic X-rays in response to the primary beam. The system further includes a spectral energy detector (SED) to perform individual photon counting and spectral analysis of the characteristic X-rays and estimate attenuation properties of the imaged sample. The sample is positioned both adjacent to a second surface of the target structure, opposite the first surface, and between the target structure and the SED.
FILED	Wednesday, October 21, 2020
APPL NO	17/076303
ART UNIT	2884 — Optics
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2251 (20130101) Original (OR) Class G01N 2223/40 (20130101) G01N 2223/079 (20130101) G01N 2223/418 (20130101) G01N 2223/507 (20130101) G01N 2223/611 (20130101) G01N 2223/3306 (20130101)
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11340217 — Catalytic particles for increased sensitivity in lateral flow immunoassays

US 11340217	Kidwell
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	David A. Kidwell (Alexandria, Virginia)
ABSTRACT	The present invention provides a method for preparing colloidal palladium nanoparticles and using them for increased sensitivity in lateral flow immunoassays. Glutaraldehyde is used in preparing the colloidal palladium that allows rapid attachment of biomolecules. Colloidal palladium nanoparticles are labeled with a protein, such as a biomolecule or an antibody. These labeled colloidal palladium particles catalytically develop a dye to detect the presence of an analyte.
FILED	Thursday, March 09, 2017
APPL NO	15/455045
ART UNIT	1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 11/02 (20130101) G01N 33/532 (20130101) G01N 33/558 (20130101) G01N 33/5306 (20130101) Original (OR) Class G01N 33/54306 (20130101) G01N 33/54333 (20130101) G01N 33/54346 (20130101) G01N 33/54353 (20130101) G01N 33/54387 (20210801) G01N 33/54388 (20210801) G01N 33/54393 (20130101)
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11340251 — Inertial measurement unit calibration stage, method, and applications

US 11340251	Lal
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Amit Lal (Ithaca, New York)
ABSTRACT	A 6-degree of freedom (DOF) PZT actuator-based dither stage includes a 6-DOF PZT Z-cut bimorph actuator-based stage. A net motion sensor includes a 6-DOF PZT Z-cut bimorph actuator-based stage and a PZT Z-cut bimorph actuator-based sensing cantilever coupled to the stage to detect motion. Methods to detect inertial sensor fixed offset, bias, and net motion are disclosed.
FILED	Monday, October 31, 2016
APPL NO	15/771515
ART UNIT	2861 — Printing/Measuring and Testing
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/56 (20130101) G01C 25/005 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/09 (20130101) Original (OR) Class G01P 15/18 (20130101) G01P 21/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/0933 (20130101)
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11340255 — Method for reducing bias drift in a microelectromechanical systems sensor

US 11340255	Moll et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	The United States of America as represented by the Secretary of the Navy (Newport, Rhode Island)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Navy (, None)
INVENTOR(S)	Christopher C Moll (San Jose, California); John G Miskimins (Port Hadlock, Washington); Ahmed S Zaki (Kingston, Rhode Island); William H Slater (New Bedford, Massachusetts); Michael J Kroger (Middletown, Rhode Island)
ABSTRACT	A method for reducing bias drift in electrical-mechanical systems sensor such as an accelerometer is provided. The method includes the steps of arranging at least one accelerometer in a chamber and initiating a plurality of temperature cycle sets. Each temperature cycle set has a minimum temperature, a maximum temperature, and a ramp rate. The conditioning method monitors the accelerometers until a bias drift is stabilized within a desired bias drift range. The minimum temperature and the maximum temperature limit a temperature range in which the accelerometer is cycled. Use of temperature limiting can quickly accelerate stabilization of the bias drift while also reducing degradation.
FILED	Tuesday, August 11, 2020
APPL NO	16/989965
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/0802 (20130101) G01P 21/00 (20130101) Original (OR) Class
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11340323 — Low acoustic noise magnetic resonance image acquisition

US 11340323	Hardy et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Congressionally Directed Medical Research Programs (CDMRP) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Christopher Judson Hardy (Schenectady, New York); Thomas Kwok-Fah Foo (Clifton Park, New York); Ek Tsoon Tan (Halfmoon, New York)
ABSTRACT	The techniques discussed herein relate to a reduced acoustic noise and vibration magnetic resonance imaging (MRI) acquisition. In certain implementations acoustic noise levels for one or more MRI pulse sequences are characterized and modified by limiting the frequencies and amplitudes of the gradient waveforms so as to produce less noise and vibration when the modified waveform is used during an MRI examination. In this manner, relatively low sound pressure levels can be attained.
FILED	Monday, January 06, 2020
APPL NO	16/735228
ART UNIT	2858 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3854 (20130101) Original (OR) Class G01R 33/4806 (20130101) G01R 33/56341 (20130101)
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11340333 — Systems and methods for improved track accuracy for multiple targets

US 11340333	Harris et al.
FUNDED BY	Department of Defense (DOD) Missile Defense Agency (MDA)
APPLICANT(S)	Reservoir Labs, Inc. (New York, New York)
ASSIGNEE(S)	Reservoir Labs, Inc. (New York, New York)
INVENTOR(S)	Mitchell Harris (New York, New York); Paul D. Mountcastle (Moorestown, New Jersey); Aditya Gudibanda (Jersey City, New Jersey)
ABSTRACT	In an apparatus for determining the state of a system in which several system components undergo respective changes simultaneously, sensor measurements obtained from the components and candidate paths representing the individual states of the different components are analyzed. In this analysis, the system state is modeled in terms of likelihoods that certain paths correspond to true parameterized paths representing individual states of the system components and likelihoods that certain observations are associated with certain components. An optimization of the model provides accurate values of each type of likelihood, which then indicate the likely state of the system.
FILED	Tuesday, June 25, 2019
APPL NO	16/451701
ART UNIT	2864 — Printing/Measuring and Testing
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/40 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101)
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11340400 — Hybrid integration for photonic integrated circuits

US 11340400	Kharas et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E) MIT Lincoln Laboratory (MITLL) Federally Funded Research and Development Center (FFRDC) Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	Boris Kharas (Lexington, Massachusetts); Reuel B. Swint (Billerica, Massachusetts); Cheryl Marie Sorace-Agaskar (Bedford, Massachusetts); Paul William Juodawlkis (Arlington, Massachusetts); Suraj Deepak Bramhavar (Arlington, Massachusetts); Jason Plant (Merrimack, Massachusetts)
ABSTRACT	Photonic integrated circuits (PICs) enable manipulation of light on a chip for telecommunications and information processing. They can be made with silicon and silicon-compatible materials using complementary metal-oxide-semiconductor (CMOS) fabrication techniques developed for making electronics. Unfortunately, most light sources are made with III-V and II-VI materials, which are not compatible with silicon CMOS fabrication techniques. As a result, the light source for a PIC is either off-chip or integrated onto the PIC after CMOS fabrication is over. Hybrid integration can be improved by forming a recess in the PIC to receive a III-V or II-VI photonic chip. Mechanical stops formed in or next to the recess during fabrication align the photonic chip vertically to the PIC. Fiducials on the PIC and the photonic chip enable sub-micron lateral alignment. As a result, the photonic chip can be flip-chip bonded to the PIC with sub-micron vertical and lateral alignment precision.
FILED	Thursday, March 05, 2020
APPL NO	16/809640
ART UNIT	2899 — Semiconductors/Memory
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) G02B 6/136 (20130101) Original (OR) Class G02B 6/02033 (20130101) G02B 6/4228 (20130101) G02B 6/4232 (20130101) G02B 6/12004 (20130101) G02B 2006/12061 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/12 (20130101) H01L 31/0232 (20130101)
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11340514 — Tunable robust topological source of indistinguishable correlated photon pairs

US 11340514	Mittal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland)
INVENTOR(S)	Sunil Mittal (Rockville, Maryland); Mohammad Hafezi (Washington, District of Columbia); Venkata Vikram Orre (College Park, Maryland); Elizabeth Goldschmidt (Urbana, Illinois)
ABSTRACT	A topological photonic system configured as a robust source of indistinguishable photons pairs with tunable spectral correlations. The system includes a two-dimensional silicon-photonic ring resonator array configured to implement an anomalous-quantum Hall model that exhibits topologically robust edge states. Linear dispersion of the edge states ensures efficient and robust phase matching and tunability of the spectral bandwidth of photon pairs generated via spontaneous four-wave mixing. Spectral tunability is manifested in the temporal correlations in the Hong-Ou-Mandel interference between photons. The generated photon pairs are energy-time entangled.
FILED	Friday, May 21, 2021
APPL NO	17/326971
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3526 (20130101) Original (OR) Class G02F 1/3536 (20130101)
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11340567 — System and method for determining manufacturability and process planning for hybrid manufacturing using symbolic, logical, and/or combinatorial representations

US 11340567	Behandish et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S)	Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California); Johan de Kleer (Los Altos, California)
ABSTRACT	A computer is provided with a geometric representation of an as-designed part and a set of hybrid manufacturing capabilities. The computer computes a set of additive and subtractive manufacturing primitives from the provided set of hybrid manufacturing capabilities, and intersects the primitives to generate an atomic decomposition of space. The computer uses the atomic decomposition to generate a non-geometric representation of a space of manufacturable parts with hybrid manufacturing capabilities in at least one of symbolic, logical, and combinatorial forms. At least one of a necessary, sufficient, or necessary-and-sufficient condition for manufacturability is tested via examining the non-geometric representation for the existence of at least one feasible process plan whose outcome is an as-manufactured part that is interchangeable with the as-designed part.
FILED	Tuesday, October 13, 2020
APPL NO	17/069087
ART UNIT	2119 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/041 (20130101) Original (OR) Class G05B 2219/13167 (20130101) Electric Digital Data Processing G06F 30/10 (20200101)
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11340616 — Motion planning for autonomous vehicles and reconfigurable motion planning processors

US 11340616	Sorin et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina); BROWN UNIVERSITY (Providence, Rhode Island)
INVENTOR(S)	Daniel J. Sorin (Durham, North Carolina); George D. Konidaris (Durham, North Carolina); William Floyd-Jones (Durham, North Carolina); Sean Murray (Durham, North Carolina)
ABSTRACT	A system for motion planning for autonomous vehicles can include a plurality of sensors, a plurality of detectors in electrical communication with the plurality of sensors, and a motion planning module in electrical communication with the plurality of detectors and a computing system of an autonomous vehicle. The motion planning module stores a planning graph with each node representing, explicitly or implicitly, time and variables defining a state of the autonomous vehicle, an operating environment, or both the state of the autonomous vehicle and the operating environment. A reconfigurable processor can include a collision detection module and, optionally, a shortest path module. Pre-computed collision data and planning graph data reflecting logical/physical node mapping can be communicated to the processor during a programming phase and used during runtime.
FILED	Friday, June 09, 2017
APPL NO	16/308693
ART UNIT	3661 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/20 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/0214 (20130101) Original (OR) Class G05D 1/0217 (20130101) G05D 1/0274 (20130101) G05D 2201/0213 (20130101) Electric Digital Data Processing G06F 16/9024 (20190101) Traffic Control Systems G08G 1/165 (20130101) G08G 1/166 (20130101)
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11341369 — Distributed batch normalization using partial populations

US 11341369	Dennison et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	NVIDIA Corporation (Santa Clara, California)
ASSIGNEE(S)	NVIDIA Corporation (Santa Clara, California)
INVENTOR(S)	Larry Robert Dennison (Mendon, Massachusetts); Benjamin Klenk (San Jose, California)
ABSTRACT	A technique for performing data parallel training of a neural network model is disclosed that incorporates batch normalization techniques using partial populations to generate normalization parameters. The technique involves processing, by each processor of a plurality of processors in parallel, a first portion of a sub-batch of training samples allocated to the processor to generate activations for the first portion of the sub-batch. Each processor analyzes the activations and transmits statistical measures for the first portion to an additional processor that reduces the statistical measures from multiple processors to generate normalization parameters for a partial population of the training samples that includes the first portion from each of the plurality of processors. The normalization parameters are then transmitted back to each of the processors to normalize the activations for both the first portion and a second portion of the sub-batch of training samples allocated to each processor.
FILED	Thursday, October 31, 2019
APPL NO	16/669925
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 7/483 (20130101) G06F 9/3885 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Original (OR) Class G06K 9/6265 (20130101) G06K 9/6298 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0481 (20130101)
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11341401 — Hardware architecture for simulating a neural network of neurons

US 11341401	Alvarez-Icaza Rivera et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)	International Business Machines Corporation (Armonk, New York)
INVENTOR(S)	Rodrigo Alvarez-Icaza Rivera (San Jose, California); John V. Arthur (Mountain View, California); Andrew S. Cassidy (San Jose, California); Pallab Datta (San Jose, California); Paul A. Merolla (Palo Alto, California); Dharmendra S. Modha (San Jose, California)
ABSTRACT	Embodiments of the invention relate to a neural network system for simulating neurons of a neural model. One embodiment comprises a memory device that maintains neuronal states for multiple neurons, a lookup table that maintains state transition information for multiple neuronal states, and a controller unit that manages the memory device. The controller unit updates a neuronal state for each neuron based on incoming spike events targeting said neuron and state transition information corresponding to said neuronal state.
FILED	Thursday, February 28, 2019
APPL NO	16/289501
ART UNIT	2122 — AI & Simulation/Modeling
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/06 (20130101) G06N 3/08 (20130101) G06N 3/049 (20130101) G06N 3/063 (20130101) Original (OR) Class G06N 3/0635 (20130101)
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11342131 — Electron acceleration and capture device for preserving excess kinetic energy to drive electrochemical reduction reactions

US 11342131	Wraback et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Michael Wraback (Germantown, Maryland); Anand V. Sampath (Montgomery Village, Maryland); Paul Shen (Potomac, Maryland); Vijay S. Parameshwaran (Greenbelt, Maryland)
ABSTRACT	Disclosed is a semiconductor-liquid junction based photoelectrochemical (PEC) cell for the unassisted solar splitting of water into hydrogen and oxygen gas, the solar-driven reduction of CO₂to higher-order hydrocarbons, and the solar-driven synthesis of NH₃. The disclosed system can employ a photocathode based upon wurtzite hexagonal semiconductors that can be tailored with proper band alignment for the redox potentials for water, CO₂reduction, and NH₃production, and with bandgap energy for maximum solar absorption. The design maximizes the carrier collection efficiency by leveraging spontaneous and piezoelectric polarization in these materials systems to generate hot electrons within the photocathode. These electrons have sufficient excess energy, preserved at a designed energy capture region, to overcome the kinetic overpotential (surface chemistry limitation) required for the reactions to occur at a high rate.
FILED	Monday, July 16, 2018
APPL NO	16/036464
ART UNIT	1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 1/55 (20210101) C25B 11/051 (20210101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/204 (20130101) H01G 9/205 (20130101) Original (OR) Class H01G 9/2054 (20130101)
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11342420 — Heterojunction devices and methods for fabricating the same

US 11342420	Kub et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Francis J. Kub (Arnold, Maryland); Travis J. Anderson (Alexandria, Virginia); Marko J. Tadjer (Springfield, Virginia); Andrew D. Koehler (Alexandria, Virginia); Karl D. Hobart (Alexandria, Virginia)
ABSTRACT	Current conducting devices and methods for their formation are disclosed. Described are vertical current devices that include a substrate, an n-type material layer, a plurality of p-type gates, and a source. The n-type material layer disposed on the substrate and includes a current channel. A plurality of p-type gates are disposed on opposite sides of the current channel. A source is disposed on a distal side of the current channel with respect to the substrate. The n-type material layer comprises beta-gallium oxide.
FILED	Tuesday, September 15, 2020
APPL NO	17/021947
ART UNIT	2891 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/242 (20130101) H01L 29/267 (20130101) Original (OR) Class H01L 29/0619 (20130101) H01L 29/0657 (20130101) H01L 29/802 (20130101) H01L 29/861 (20130101) H01L 29/1066 (20130101) H01L 29/1602 (20130101) H01L 29/2003 (20130101) H01L 29/7827 (20130101) H01L 29/7828 (20130101) H01L 29/8611 (20130101) H01L 29/66666 (20130101) H01L 29/66916 (20130101) H01L 29/66924 (20130101) H01L 29/66969 (20130101)
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11342438 — Device with heteroepitaxial structure made using a growth mask

US 11342438	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Cudjoe Key, Florida); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Wednesday, October 17, 2018
APPL NO	16/162787
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342441 — Method of forming a seed area and growing a heteroepitaxial layer on the seed area

US 11342441	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Tuesday, January 21, 2020
APPL NO	16/747765
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342442 — Semiconductor product comprising a heteroepitaxial layer grown on a seed area of a nanostructured pedestal

US 11342442	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Tuesday, January 21, 2020
APPL NO	16/748095
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342482 — Gallium nitride cross-gap light emitters based on unipolar-doped tunneling structures

US 11342482	Brown et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Wright State University (Dayton, Ohio); The Government of the United States of America, As Represented By The Secretary Of The Navy (Arlington, Virginia); OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio)
ASSIGNEE(S)	Wright State University (Dayton, Ohio); The Government of the United States of America, As Represented By The Secretary Of The Navy (Arlington, Virginia); Ohio State Innovation Foundation (Columbus, Ohio)
INVENTOR(S)	Elliott R. Brown (Beavercreek, Ohio); Weidong Zhang (Cary, North Carolina); Tyler Growden (Dublin, Ohio); Paul Berger (Columbus, Ohio); David Storm (Washington, District of Columbia); David Meyer (Washington, District of Columbia)
ABSTRACT	Gallium nitride based devices and, more particularly to the generation of holes in gallium nitride based devices lacking p-type doping, and their use in light emitting diodes and lasers, both edge emitting and vertical emitting. By tailoring the intrinsic design, a wide range of wavelengths can be emitted from near-infrared to mid ultraviolet, depending upon the design of the adjacent cross-gap recombination zone. The innovation also provides for novel circuits and unique applications, particularly for water sterilization.
FILED	Monday, October 28, 2019
APPL NO	16/665358
ART UNIT	2828 — Semiconductors/Memory
CURRENT CPC	Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/325 (20130101) C02F 2201/3222 (20130101) C02F 2201/3228 (20130101) C02F 2303/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/882 (20130101) H01L 29/2003 (20130101) H01L 33/06 (20130101) Original (OR) Class H01L 33/007 (20130101) H01L 33/12 (20130101) H01L 33/32 (20130101) H01L 33/50 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/141 (20130101) H01S 5/187 (20130101) H01S 5/0213 (20130101) H01S 5/0425 (20130101) H01S 5/3095 (20130101) H01S 5/3401 (20130101) H01S 5/18341 (20130101) H01S 5/18369 (20130101) H01S 5/34333 (20130101) H01S 2304/02 (20130101) H01S 2304/04 (20130101)
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11342493 — High coherence, small footprint superconducting qubit made by stacking up atomically thin crystals

US 11342493	Oliver et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S)	William D. Oliver (Arlington, Massachusetts); Simon Gustavsson (Cambridge, Massachusetts); I-Jan Wang (Cambridge, Massachusetts)
ABSTRACT	A superconducting qubit is manufactured by stacking up atomically-thin, crystalline monolayers to form a heterostructure held together by van der Waals forces. Two sheets of superconducting material are separated by a third, thin sheet of dielectric to provide both a parallel plate shunting capacitor and a Josephson tunneling barrier. The superconducting material may be a transition metal dichalcogenide (TMD), such as niobium disilicate, and the dielectric may be hexagonal boron nitride. The qubit is etched, or material otherwise removed, to form a magnetic flux loop for tuning. The heterostructure may be protected by adhering additional layers of the dielectric or other insulator on its top and bottom. For readout, the qubit may be coupled to an external resonator, or the resonator may be integral with one of the sheets of superconducting material.
FILED	Monday, November 30, 2020
APPL NO	17/106562
ART UNIT	2896 — Semiconductors/Memory
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) Original (OR) Class H01L 39/2416 (20130101) H01L 39/2493 (20130101)
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11342589 — Calcium salt for calcium batteries

US 11342589	Buttry et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Army Research Office (CCDC ARO)
APPLICANT(S)	ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)	Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S)	Daniel Buttry (Tempe, Arizona); Joseph Rheinhardt (Phoenix, Arizona)
ABSTRACT	Disclosed is a calcium salt, Ca(HMDS)₂, where HMDS is the hexamethyldisilazide anion (also known as bis(trimethylsilyl)amide), enables high current densities and high coulombic efficiency for calcium metal deposition and dissolution. These properties facilitate the use of this salt in batteries based on calcium metal. In addition, the salt is significant for batteries based on metal anodes, which have higher specific energies than batteries based on intercalation anodes, such as LiC₆. In particular, a calcium based rechargeable battery includes Ca(HMDS)₂salt and at least one solvent, the solvent suitable for calcium battery cycling. The at least one solvent can be diethyl ether, diisopropylether, methyl t-butyl ether (MTBE), 1,3-dioxane, 1,4-dioxane, tetrahydrofuran (THF), tetrahydropyran, glyme, diglyme, triglyme or tetraglyme, or any mixture thereof.
FILED	Monday, November 25, 2019
APPL NO	16/694950
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/44 (20130101) H01M 10/0565 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0025 (20130101) H01M 2300/0085 (20130101)
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11342854 — Voltage step-up converter circuits for low input voltages

US 11342854	Urciuoli
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL)
APPLICANT(S)	U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland)
ASSIGNEE(S)	The United States of America as represented by the Secretary of the Army (Washington, District of Columbia)
INVENTOR(S)	Damian P. Urciuoli (Bowie, Maryland)
ABSTRACT	Novel voltage converter circuits are provided which step-up very low DC input voltages to higher voltages capable of supporting low-power loads. According to embodiments, a voltage step-up power converter circuit may be formed of an oscillator sub-circuit which receives a DC voltage and outputs an AC voltage; a voltage doubler sub-circuit which receives the AC voltage and outputs an augmented AC voltage; and a voltage step-up converter sub-circuit which receives the augmented AC voltage, as a control voltage, and the initial DC voltage and outputs a voltage which is more than the initial DC voltage. These circuits allow electrical energy to be harvested from very low voltage sources and to convert it as efficiently as possible to run a load.
FILED	Friday, December 18, 2020
APPL NO	17/126256
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/33569 (20130101) Original (OR) Class Electric Heating; Electric Lighting Not Otherwise Provided for H05B 45/38 (20200101) H05B 45/385 (20200101)
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11342919 — Complementary asynchronous single flux quantum circuits

US 11342919	Whiteley
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	Synopsys, Inc. (Mountain View, California)
ASSIGNEE(S)	Synopsys, Inc. (Mountain View, California)
INVENTOR(S)	Stephen Robert Whiteley (Sunnyvale, California)
ABSTRACT	A single flux quantum (SFQ) cell may include SFQ circuitry to implement a logic function that generates logic values of a set of outputs based on logic values of a set of inputs. The SFQ circuitry may instantaneously update logic values of the set of outputs in response to changes in logic values of the set of inputs. The SFQ circuitry may include at least one SFQ non-destructive set-reset flip-flop.
FILED	Friday, August 21, 2020
APPL NO	16/999957
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 3/38 (20130101) H03K 19/195 (20130101) Original (OR) Class
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11342921 — Single flux quantum buffer circuit

US 11342921	Whiteley
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	Synopsys, Inc. (Mountain View, California)
ASSIGNEE(S)	Synopsys, Inc. (, None)
INVENTOR(S)	Stephen Robert Whiteley (Sunnyvale, California)
ABSTRACT	A circuit can include a first Josephson junction (JJ), a second JJ, and a third JJ coupled in parallel using superconducting inductors. The first JJ, the second JJ, and the third JJ can be biased using one or more JJ-based current sources.
FILED	Friday, July 10, 2020
APPL NO	16/926388
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 17/92 (20130101) H03K 19/0008 (20130101) H03K 19/1952 (20130101) Original (OR) Class H03K 2217/0036 (20130101)
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11342937 — Adaptive cross-layer error control coding for heterogeneous application environments

US 11342937	Gabrys et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Information Warfare Center (NIWC) Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S)	The United States of America as Represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)	United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S)	Ryan Christopher Gabrys (San Diego, California); Jayson T. Durham (San Diego, California)
ABSTRACT	At a physical data-link in a network, a current status of a plurality of logical data-channels in the network is determined, using machine learning to infer the current status. A plurality of cross-layer error correction coding schemes for transmissions is adaptively adjusted, based on the determined current status, and based on an application transmitting data. Transmission of the data, and a plurality of information-exchange requirements, are supported, using the adaptively adjusted plurality of error correction coding schemes.
FILED	Tuesday, February 11, 2020
APPL NO	16/788051
ART UNIT	2112 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Coding; Decoding; Code Conversion in General H03M 13/1515 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0061 (20130101) H04L 25/024 (20130101) H04L 43/12 (20130101)
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11342946 — Neural network kernels for signal processing in lieu of digital signal processing in radio receivers

US 11342946	Bhatia et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	Amit Bhatia (Apex, North Carolina); Joseph M. Carmack (Milford, New Hampshire); Scott A Kuzdeba (Hollis, New Hampshire); Joshua W. Robinson (Durham, North Carolina)
ABSTRACT	An artifact-suppressing neural network (NN) kernel comprising at least one neural network, implemented in replacement of a DSP, provides comparable or better performance under non-edge conditions, and superior performance under edge conditions, due to the ease of updating the NN kernel training without enlarging its computational footprint or latency to address a new edge condition. In embodiments, the NN kernel can be implemented in a field programmable gate array (FPGA) or application specific integrated circuit (ASIC), which can be configured as a direct DSP replacement. In various embodiments, the NN kernel training can be updated in near real time when a new edge condition is encountered in the field. The NN kernel can include DCC lower layers and dense upper layers. Initial NN kernel training can require fewer examples. Example embodiments include a noise suppression NN kernel and a modem NN kernel.
FILED	Monday, March 22, 2021
APPL NO	17/208304
ART UNIT	2633 — Digital Communications
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Transmission H04B 1/0014 (20130101) Original (OR) Class H04B 1/1036 (20130101)
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11343715 — Header compression for network

US 11343715	Barbulescu et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
ASSIGNEE(S)	Rockwell Collins, Inc. (Cedar Rapids, Iowa)
INVENTOR(S)	Ion Barbulescu (Cedar Rapids, Iowa); James A. Stevens (Lucas, Texas)
ABSTRACT	A multi-node communication network may include a plurality of nodes including a first node and a second node. Each of the plurality of nodes may include a communication interface and a controller. The first node may be configured to: obtain an uncompressed packet, the uncompressed packet having uncompressed header data and a payload; compress the uncompressed header data into compressed header data having a tag and at least one compressed unit (CU), the tag indicating at least one type of compression for the at least one CU; and transmit a packet having the compressed header data and the payload to the second node. The second node may be configured to: receive the packet having the compressed header data and the payload; and based at least on the tag, decompress the at least one CU.
FILED	Sunday, August 23, 2020
APPL NO	17/000317
ART UNIT	2416 — Multiplex and VoIP
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1095 (20130101) H04L 69/04 (20130101) Wireless Communication Networks H04W 28/06 (20130101) Original (OR) Class H04W 84/18 (20130101)
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Department of Energy (DOE)

11338348 — Method and apparatus for double-sided incremental flanging

US 11338348	Zhang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Northwestern University (Evanston, Illinois); Shanghai Jiao Tong University (Shanghai, China PRC)
ASSIGNEE(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); SHANGHAI JIAO TONG UNIVERSITY (Shanghai, China PRC)
INVENTOR(S)	Huan Zhang (Shanghai, China PRC); Jian Cao (Wilmette, Illinois); Kornel Ehmann (Evanston, Illinois); Jun Chen (Shanghai, China PRC)
ABSTRACT	Flanges formed on sheet metal parts to increase the part stiffness or create mating surface for further assembly are created in an incremental sheet forming process using forming tool and supporting tool that move along a specified tool path so as to gradually deform a peripherally-clamped sheet metal work piece into the desired geometry. With two universal tools moving along the designed toolpath on the both sides of the part, the process is very flexible. Process time is can also be reduced by utilizing an accumulative double-sided incremental hole-flanging strategy, in which the flange is formed in only one step.
FILED	Monday, May 14, 2018
APPL NO	16/613885
ART UNIT	3725 — Manufacturing Devices & Processes, Machine Tools & Hand Tools Group Art Units
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/005 (20130101) Original (OR) Class
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11338390 — Two-color high speed thermal imaging system for laser-based additive manufacturing process monitoring

US 11338390	Calta et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S)	Nicholas P. Calta (San Jose, California); Gabe Guss (Manteca, California); Manyalibo Joseph Matthews (Livermore, California)
ABSTRACT	Monitoring melt pool temperature in laser powder bed fusion by providing a build laser that produces a laser beam that is directed onto the melt pool and produces an incandescence that emanates from the melt pool, receiving the incandescence and producing a first image having a first spectral band and a second image having a second spectral band, and determining the ratio of said first image having a first spectral band and said second image having a second spectral band to monitor the melt pool temperature.
FILED	Tuesday, February 12, 2019
APPL NO	16/273953
ART UNIT	3761 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/032 (20130101) B23K 26/034 (20130101) B23K 26/342 (20151001) Original (OR) Class B23K 26/702 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/00 (20141201) Image Data Processing or Generation, in General G06T 5/20 (20130101) G06T 7/0016 (20130101) G06T 7/70 (20170101)
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11339058 — Manufacturing of perovskite films

US 11339058	Whitaker et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S)	James Bacon Whitaker (Denver, Colorado); Kai Zhu (Littleton, Colorado); Marinus Franciscus Antonius Maria van Hest (Lakewood, Colorado)
ABSTRACT	The present disclosure relates to a mixture that includes a perovskite precursor, a solvent, and an additive that includes at least one of a first amine, a ketone, an aldehyde, a non-nucleophilic sterically hindered base, and/or a halogen-containing compound, where, upon removal of the solvent and the additive, the perovskite precursor is capable of being transformed into a perovskite.
FILED	Friday, December 13, 2019
APPL NO	16/713424
ART UNIT	1761 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 21/16 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/72 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/005 (20130101)
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11339094 — Mitigation of alkali-silica reaction in concrete using readily-soluble chemical additives

US 11339094	Sant et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); YARA INTERNATIONAL ASA (Oslo, Norway); CONSTRUCTION RESEARCH and TECHNOLOGY GMBH (Trostberg, Germany)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Yara International ASA (Oslo, Norway); CONSTRUCTION RESEARCH and TECHNOLOGY GMBH (Trostberg, Germany)
INVENTOR(S)	Gaurav N. Sant (Los Angeles, California); Gabriel D. Falzone (Los Angeles, California); Tandre Oey (Los Angeles, California); Wolfram Franke (Los Angeles, California); Paul Seiler (Los Angeles, California); Erika Callagon La Plante (Los Angeles, California)
ABSTRACT	A manufacturing method includes: (1) incorporating at least one soluble, calcium, magnesium, or other divalent cation-containing additive into a concrete mixture including aggregates prone to alkali-silica reaction; and (2) curing the concrete mixture to form a concrete product.
FILED	Monday, August 13, 2018
APPL NO	16/638720
ART UNIT	1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/06 (20130101) C04B 14/22 (20130101) C04B 20/1074 (20130101) C04B 22/085 (20130101) Original (OR) Class C04B 22/124 (20130101) C04B 28/02 (20130101) C04B 2103/603 (20130101) C04B 2111/2023 (20130101)
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11339326 — Tl+-based and mixed halide A3B2X9-type scintillators

US 11339326	Rutstrom et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) National Nuclear Security Administration (NNSA)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Daniel Joseph Rutstrom (Knoxville, Tennessee); Luis Stand (Knoxville, Tennessee); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee)
ABSTRACT	Inorganic halides (e.g., inorganic halide scintillators) of the general formula A₃B₂X₉, including inorganic halides comprising thallium monovalent cations and/or combinations of different halides, are described. Radiation detectors including the inorganic halide scintillators and methods of using the detectors to detect high energy radiation are also described. In some cases, the scintillators can include a gadolinium cation, a boron cation, a lithium cation, a chloride ion, or combinations thereof and the scintillator can be used to detect neutrons.
FILED	Friday, January 22, 2021
APPL NO	17/156124
ART UNIT	2884 — Optics
CURRENT CPC	Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/36 (20200101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/88 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7773 (20130101) Original (OR) Class Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/12 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) G01T 3/06 (20130101)
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11339360 — Culture systems and methods of using same

US 11339360	He et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC)
APPLICANT(S)	AUBURN UNIVERSITY (Auburn, Alabama)
ASSIGNEE(S)	Auburn University (Auburn, Alabama)
INVENTOR(S)	Qinghua He (Auburn, Alabama); Jin Wang (Auburn, Alabama); Matthew V. Hilliard (Pelham, Georgia)
ABSTRACT	Culture systems and methods of using same. The systems include a housing defining an inner space. The inner space includes a headspace and at least a portion of a reservoir. A surface for immobilizing cells is moveable between the headspace and the reservoir. The systems can be used for coculturing methanotrophs and phototrophs for processing biogas and wastewater, particularly from anaerobic digesters.
FILED	Tuesday, July 21, 2020
APPL NO	16/934766
ART UNIT	1778 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Separation B01D 53/62 (20130101) B01D 53/72 (20130101) B01D 53/85 (20130101) B01D 2251/95 (20130101) B01D 2257/504 (20130101) B01D 2257/7022 (20130101) B01D 2258/05 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/325 (20130101) C02F 3/341 (20130101) C02F 3/2806 (20130101) C02F 3/2813 (20130101) C02F 3/2866 (20130101) C02F 2101/16 (20130101) C02F 2101/105 (20130101) C02F 2203/006 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) Original (OR) Class C12M 23/18 (20130101) C12M 23/36 (20130101) C12M 23/58 (20130101) C12M 27/00 (20130101) C12M 29/00 (20130101) C12M 41/00 (20130101) C12M 43/00 (20130101)
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11339434 — Methods for determining gene functions

US 11339434	de Raad et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Markus de Raad (Berkeley, California); Trent R. Northen (Walnut Creek, California); Curt R. Fischer (Mountain View, California)
ABSTRACT	Disclosed herein are methods, systems and compositions for determining substrate specificity of an enzyme. The disclosed methods, systems and compositions can be used for identifying enzymes capable of modifying substrates of interest and/or quantifying enzymatic activity.
FILED	Friday, July 28, 2017
APPL NO	15/663528
ART UNIT	1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/25 (20130101) C12Q 1/6872 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101)
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11339665 — Blade and airfoil damping configurations

US 11339665	Hart et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Andrew Clifford Hart (Greenville, South Carolina); Jing Li (Niskayuna, New York); Suryarghya Chakrabarti (Niskayuna, New York); James Tyson Balkcum, III (Taylors, South Carolina); Markus Feigl (Simpsonville, South Carolina)
ABSTRACT	The present embodiments set forth a blade including an airfoil, the airfoil including a tip cap, a pressure sidewall and a suction sidewall extending axially between corresponding leading and trailing edges and radially between the base and the tip cap. The blade, including the airfoil and base, being formed in at least two airfoil parts, each of the two airfoil parts including contacting edges engaging each other respective contacting edges, the contacting edges defining a joint for preloading each of the at least two parts with each other and with the base. The at least two airfoil parts forming the airfoil being retained to each other by an interference fit at the joint. The interference fit providing frictional damping of vibrations in the blade during blade operation.
FILED	Thursday, March 12, 2020
APPL NO	16/816568
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class F01D 5/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2240/30 (20130101) F05D 2260/96 (20130101) F05D 2260/221 (20130101)
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11339666 — Airfoil with cavity damping

US 11339666	Hart et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL)
APPLICANT(S)	General Electric Company (Schenectady, New York)
ASSIGNEE(S)	General Electric Company (Schenectady, New York)
INVENTOR(S)	Andrew Clifford Hart (Greenville, South Carolina); John McConnell Delvaux (Fountain Inn, South Carolina); Joseph Anthony Weber (Simpsonville, South Carolina); James Zhang (Simpsonville, South Carolina); Peter de Diego (Zirconia, North Carolina)
ABSTRACT	An article, such as a turbine blade, includes an airfoil. The airfoil includes a body, the body having an elongated internal cavity extending from a tip of the body. The cavity is defined an internal wall within the body. At least one elongated damping element is disposed in the elongated internal cavity and frictionally engages the internal wall. Thus, the least one elongated damping element is capable of damping vibrations in the article.
FILED	Friday, April 17, 2020
APPL NO	16/851629
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class F01D 5/26 (20130101) F01D 5/147 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2240/304 (20130101) F05D 2240/307 (20130101) F05D 2250/185 (20130101) F05D 2260/96 (20130101) F05D 2260/201 (20130101) F05D 2260/202 (20130101)
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11339766 — Redox-active oxide materials for thermal energy storage

US 11339766	Babiniec et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Sean M. Babiniec (Arvada, Colorado); Andrea Ambrosini (Albuquerque, New Mexico); Eric N. Coker (Albuquerque, New Mexico); James E. Miller (Albuquerque, New Mexico)
ABSTRACT	Thermochemical storage materials having the general formula A_xA′_1-xB_yB′_1-yO_3-δ, where A=La, Sr, K, Ca, Ba, Y and B=Mn, Fe, Co, Ti, Ni, Cu, Zr, Al, Y, Cr, V, Nb, Mo, are disclosed. These materials have improved thermal storage energy density and reaction kinetics compared to previous materials. Concentrating solar power thermochemical systems and methods capable of storing heat energy by using these thermochemical storage materials are also disclosed.
FILED	Wednesday, September 18, 2019
APPL NO	16/574169
ART UNIT	1759 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/125 (20130101) C01G 45/1264 (20130101) C01G 49/009 (20130101) C01G 51/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/34 (20130101) C01P 2002/72 (20130101) C01P 2006/90 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 6/003 (20130101) Original (OR) Class F03G 6/064 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/003 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/46 (20130101)
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11339845 — Total-internal reflection elastic metasurfaces: design and application

US 11339845	Walsh et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Fabio Semperlotti (West Lafayette, Indiana); Hongfei Zhu (West Lafayette, Indiana)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Timothy Walsh (West Lafayette, Indiana); Fabio Semperlotti (West Lafayette, Indiana); Hongfei Zhu (West Lafayette, Indiana)
ABSTRACT	An acoustic shield for protecting a vibrational sensitive device includes a first unit cell and a second unit cell. The first unit cell includes a first locally resonant unit. The first locally resonant unit controls a first phase gradient and the first unit cell includes a first surface. The second unit cell includes a second surface proximate to the first surface. The second unit cell includes a second locally resonant unit embedded along the second interface. The second locally resonant unit controls a second phase gradient. The first phase gradient is different from the second phase gradient. The first unit cell and the second unit cell comprise a super cell. The acoustic shield is configured such that a vibrational wave from a first side of the super cell to a second side of the super cell is substantially attenuated.
FILED	Wednesday, May 15, 2019
APPL NO	16/413441
ART UNIT	2837 — Electrical Circuits and Systems
CURRENT CPC	Springs; Shock-absorbers; Means for Damping Vibration F16F 9/306 (20130101) Original (OR) Class Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/168 (20130101)
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11339847 — Systems and methods for additive manufacturing to encapsulate transformative colloidal suspensions

US 11339847	Mancini et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University Of California (Oakland, California)
INVENTOR(S)	Julie A. Mancini (Livermore, California); Eric B. Duoss (Danville, California); Alexandra Golobic (Oakland, California); Mark Christian Messner (Tracy, California); Christopher M. Spadaccini (Oakland, California); Kenneth J. Loh (San Diego, California)
ABSTRACT	The present disclosure relates to an energy absorbing three dimensional (3D) structure. The structure may have an outer shell formed from a shell material. The outer shell may have a void forming a core volume. A transformative feedstock is contained in the void. The transformative feedstock is encapsulated within the outer shell, within the void, and provides enhanced energy absorbing properties to the 3D structure.
FILED	Thursday, April 16, 2020
APPL NO	16/850701
ART UNIT	1744 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2995/0008 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2009/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Springs; Shock-absorbers; Means for Damping Vibration F16F 9/532 (20130101) F16F 9/535 (20130101) Original (OR) Class F16F 2226/04 (20130101)
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11340023 — Counter gravity heat pipe techniques

US 11340023	Reid et al.
FUNDED BY	Department of Energy (DOE) Los Alamos National Security, LLC (LANS) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Robert S. Reid (Santa Fe, New Mexico); Robert A. Zimmerman (Los Alamos, New Mexico); Cody M. Williams (San Diego, California); Morgan T. Biel (Los Alamos, New Mexico); Stephen J. Obrey (Los Alamos, New Mexico); Todd A. Jankowski (Los Alamos, New Mexico); Justin Simpson (Albuquerque, New Mexico); Martin J. Ward (Austin, Texas); Lydia Wermer (Notre Dame, Indiana)
ABSTRACT	A pump assisted heat pipe may combine the low mass flow rate required of latent heat pipe transfer loops with a hermetically sealed pump to overcome the typical heat pipe capillary limit. This may result in a device with substantially higher heat transfer capacity over conventional pumped single-phase loops, heat pipes, loop heat pipes, and capillary pumped loops with very modest power requirements to operate. Further, one or more embodiments overcome the gravitation limitations in the conventional heat pipe configuration, e.g., when the heat addition zone is above the heat rejection zone, the capillary forces are required to transfer the liquid from the heat rejection zone to the heat addition zone against gravity.
FILED	Thursday, March 15, 2018
APPL NO	15/921800
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/043 (20130101) Original (OR) Class F28D 15/0266 (20130101) F28D 15/0275 (20130101) F28D 2015/0216 (20130101) F28D 2015/0291 (20130101) F28D 2021/0054 (20130101) Nuclear Reactors G21C 15/02 (20130101) G21C 15/243 (20130101) G21C 15/257 (20130101)
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11340057 — Systems and methods for interferometric multifocus microscopy

US 11340057	He et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Kuan He (Cupertino, California); Oliver Strider Cossairt (Evanston, Illinois); Aggelos K. Katsaggelos (Chicago, Illinois); Norbert Scherer (Chicago, Illinois); Mark Hereld (Chicago, Illinois)
ABSTRACT	A system to generate image representations includes a first objective that receives a first light beam emitted from a sample and a second objective that receives a second light beam emitted from the sample, where the first light beam and the second light beam have conjugate phase. The system also includes a first diffractive element to receive the first light beam and separate it into a first plurality of diffractive light beams that are spatially distinct, and a second diffractive element to receive the second light beam and separate it into a second plurality of diffractive light beams that are spatially distinct. The system further includes a detector that receives the first and second plurality of diffractive light beams. The first plurality of diffractive light beams and the second plurality of diffractive light beams are simultaneously directed and focused onto different portions of an image plane of the detector.
FILED	Friday, June 21, 2019
APPL NO	15/734172
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/04 (20130101) Original (OR) Class G01B 9/02041 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4788 (20130101) Optical Elements, Systems, or Apparatus G02B 21/361 (20130101)
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11340110 — System and method for assessing spectroscopic sensor accuracy

US 11340110	Green et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)	INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S)	William Green (Yorktown Heights, New York); Eric Zhang (Yorktown Heights, New York)
ABSTRACT	A method for assessing spectroscopic sensor accuracy, includes building an a priori simulation of generalized etalon drift. A spectroscopic sensor is tested to determine use parameters. A specific drift model is generated by applying the determined use parameters to the built a priori simulation of generalized etalon drift. The specific drift model is analyzed to determine whether the spectroscopic sensor is satisfactory.
FILED	Thursday, September 06, 2018
APPL NO	16/123859
ART UNIT	2877 — Optics
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/021 (20130101) G01J 3/027 (20130101) Original (OR) Class G01J 3/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/274 (20130101)
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11340181 — Methods and systems for low to ultra-low magnetic field nuclear magnetic resonance for detecting chemical nerve agents

US 11340181	Williams et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Robert F. Williams (Los Alamos, New Mexico); Michelle A. Espy (Los Alamos, New Mexico); Jacob Luther Yoder (Los Alamos, New Mexico); Derrick C. Kaseman (Los Alamos, New Mexico); Per Erik Magnelind (Los Alamos, New Mexico); Algis V. Urbaitis (Los Alamos, New Mexico); Michael Timothy Janicke (Los Alamos, New Mexico); Ryszard Michalczyk (Los Alamos, New Mexico); Jurgen G. Schmidt (Los Alamos, New Mexico); Pulak Nath (Los Alamos, New Mexico); Scarlett Widgeon Paisner (Los Alamos, New Mexico)
ABSTRACT	A nuclear magnetic resonance (NMR) system is configured to detect chemical threat material. The system comprises a magnet configured to generate a magnetic field of about 300 millitesla or less; and a probe configured to detect nuclear relaxation of at least two nuclei selected from the group consisting of ¹H, ¹⁹F, ³¹P and ¹⁴N, and detect the spin density of nuclei selected from the group consisting of ¹H, ¹⁹F, ³¹P and ¹⁴N, following excitation.
FILED	Monday, March 02, 2020
APPL NO	16/806954
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/081 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/307 (20130101) G01R 33/383 (20130101) G01R 33/445 (20130101) G01R 33/3815 (20130101)
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11340261 — Flexible electric probe

US 11340261	Mazzeo et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	Brigham Young University (BYU) (Provo, Utah)
ASSIGNEE(S)	BRIGHAM YOUNG UNIVERSITY (Provo, Utah)
INVENTOR(S)	Brian A. Mazzeo (Provo, Utah); John Vogel (Orem, Utah); Dean Wheeler (Orem, Utah); Emilee Hardy (Meridian, Idaho); Derek Clement (Kent, Washington)
ABSTRACT	A flexible electric probe can include: a flexible substrate; and probe line conductors on the flexible substrate, the probe line conductors being essentially parallel to each other and having separations of about 5-50 microns. The flexible electric probe can further include connection conductors on the flexible substrate, the connection conductors and the probe line conductors electrically connected to each other, the probe line conductors positioned in first and second offset patterns with regard to the connection conductors.
FILED	Friday, February 02, 2018
APPL NO	16/483153
ART UNIT	2867 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 1/0735 (20130101) Original (OR) Class
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11340396 — Non-circular optical fiber and mode shape converter and method

US 11340396	Drachenberg et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
INVENTOR(S)	Derrek R. Drachenberg (Livermore, California); Graham S. Allen (Pleasanton, California); Diana C. Chen (Fremont, California); Matthew J. Cook (Brentwood, California); Robert P. Crist (Tracy, California); Jay W. Dawson (Livermore, California); Leily Kiani (Napa, California); Michael J. Messerly (Danville, California); Paul H. Pax (Livermore, California); Nick Schenkel (Livermore, California); Charles X. Yu (Pleasanton, California)
ABSTRACT	A class of fibers is described that have a non-circular cross section on one or both ends that can by optimized to capture the optical radiation from a laser diode or diode array and deliver the light in the same or different shape on the opposite end of the fiber. A large multimode rectangular waveguide may be provided which can accept the radiation from a high-power diode bar and transform it into a circular cross section on the opposite end, while preserving brightness.
FILED	Thursday, July 05, 2018
APPL NO	16/626947
ART UNIT	2874 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/12 (20130101) G02B 6/0288 (20130101) Original (OR) Class G02B 6/4202 (20130101) G02B 2006/1209 (20130101) G02B 2006/12102 (20130101) G02B 2006/12121 (20130101)
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11341217 — Enhancing obfuscation of digital content through use of linear error correction codes

US 11341217	Corral
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Celestino A. Corral (Milpitas, California)
ABSTRACT	Technologies related to enhancing security of digital content are described. Linear error correction codes (LECCs) are employed for dual purposes: 1) to obfuscate digital content; and 2) to verify integrity of the digital content. A transmitter computing system obfuscates digital content based upon an obfuscation protocol, wherein the obfuscated digital content includes an LECC. A receiver computing system deobfuscates the digital content by performing the inverse of the obfuscation protocol.
FILED	Thursday, November 05, 2020
APPL NO	17/090304
ART UNIT	2111 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC	Electric Digital Data Processing G06F 21/14 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 13/15 (20130101) H03M 13/091 (20130101)
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11341224 — Handheld multi-sensor biometric imaging device and processing pipeline

US 11341224	Bolme et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)	UT Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S)	David S. Bolme (Oak Ridge, Tennessee); Hector J. Santos Villalobos (Oak Ridge, Tennessee); Aravind K. Mikkilineni (Knoxville, Tennessee)
ABSTRACT	A handheld biometric imaging device having an array of cameras configured to simultaneously capture face, iris and fingerprint biometrics of a subject. The device includes a plurality of visible-light cameras and a plurality of infrared-light cameras capable of being triggered simultaneously to obtain a plurality of images from which a 3D image of the light field can be constructed. The device includes a plurality of visible-light illuminators and a plurality of infrared-light illuminators that allow images of a subject to be captured under different lighting profiles. The device may include an onboard control system that is capable of reconstructing a face region, an iris region and a fingerprint region from the 3D light-field image, and then extract a corresponding face template, an iris template, and a fingerprint template from the respective reconstructed regions. The extracted face, iris, and fingerprint templates may be used for enrollment and/or comparison against a biometric-template database associated with one or more watchlists.
FILED	Friday, January 29, 2021
APPL NO	17/162319
ART UNIT	2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class Image or Video Recognition or Understanding G06V 10/60 (20220101) G06V 40/50 (20220101) G06V 40/70 (20220101) Pictorial Communication, e.g Television H04N 5/33 (20130101)
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11341410 — Subsurface stress criticality associated with fluid injection and determined using machine learning

US 11341410	Johnson et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)	Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S)	Paul Allan Johnson (Nambe, New Mexico); Claudia L. Hulbert (Los Alamos, New Mexico); Bertrand Rouet-Leduc (Los Alamos, New Mexico)
ABSTRACT	Machine-learning methods and apparatus are disclosed to determine critical state or other parameters related to fluid-driven failure of a terrestrial locale impacted by anthropogenic activities such as hydraulic fracturing, hydrocarbon extraction, wastewater disposal, or geothermal harvesting. Acoustic emission, seismic waves, or other detectable indicators of microscopic processes are sensed. A classifier is trained using time series of microscopic data along with corresponding data of critical state or failure events. In disclosed examples, random forests and artificial neural networks are used, and grid-search or EGO procedures are used for hyperparameter tuning. Once trained, the classifier can be applied to live data from a fluid injection locale in order to assess a frictional state, assess seismic hazard, assess permeability, make predictions regarding a future fluid-driven failure event, or drive engineering solutions for mitigation or remediation. Variations are disclosed.
FILED	Friday, December 06, 2019
APPL NO	16/706166
ART UNIT	2857 — Printing/Measuring and Testing
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 5/02 (20130101) G06N 20/10 (20190101) G06N 20/20 (20190101)
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11342130 — Method of making a photovoltaic device on a substrate at high speed with perovskite solution

US 11342130	Christensen et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Solar Energy Technologies Office (SETO)
APPLICANT(S)	Energy Materials Corporation (Rochester, New York)
ASSIGNEE(S)	Energy Materials Corporation (Rochester, New York)
INVENTOR(S)	Scott Kenneth Christensen (North Chili, New York); Qi Li (Rochester, New York); Thomas Nathaniel Tombs (Rochester, New York); Stephan J. DeLuca (Meadville, Pennsylvania)
ABSTRACT	A continuous inline method for production of photovoltaic devices at high speed includes: providing a substrate; depositing a first carrier transport solution layer with a first carrier transport deposition device to form a first carrier transport layer on the substrate; depositing a Perovskite solution comprising solvent and perovskite precursor materials with a Perovskite solution deposition device on the first carrier transport layer; drying the deposited Perovskite solution to form a Perovskite absorber layer; and depositing a second carrier transport solution with a second carrier transport deposition device to form a second carrier transport layer on the Perovskite absorber layer, wherein the deposited Perovskite solution is dried at least partially with a fast drying device which causes a conversion reaction and the Perovskite solution to change in optical density by at least a factor of 2 in less than 0.5 seconds after the fast drying device first acts on the Perovskite solution.
FILED	Thursday, May 30, 2019
APPL NO	16/426341
ART UNIT	2893 — Semiconductors/Memory
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Original (OR) Class H01G 9/2018 (20130101) H01G 9/2095 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0004 (20130101) H01L 51/0007 (20130101) H01L 51/0027 (20130101) H01L 51/0028 (20130101) H01L 51/0077 (20130101) H01L 51/0097 (20130101) H01L 51/442 (20130101) H01L 51/4253 (20130101)
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11342500 — Antiferromagnetic memory storage devices from magnetic transition metal dichalcogenides

US 11342500	Analytis et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	James G. Analytis (San Francisco, California); Eran Maniv (Berkeley, California); Nityan L. Nair (Berkeley, California); Spencer Doyle (San Luis Obispo, California); Caolan John (Altadena, California)
ASSIGNEE(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S)	James G. Analytis (San Francisco, California); Eran Maniv (Berkeley, California); Nityan L. Nair (Berkeley, California); Spencer Doyle (San Luis Obispo, California); Caolan John (Altadena, California)
ABSTRACT	Switchable antiferromagnetic (AFM) memory devices are provided based on magnetically intercalated transition metal dichalcogenides (TMDs) of the form A_xMC₂, where A is a magnetic element of stoichiometry x between 0 and 1, M is a transition metal of stoichiometry 1, and C is a chalcogen of stoichiometry 2. Memory storage is achieved by fabricating these materials into crosses of two or more bars and driving DC current pulses along the bars to rotate the AFM order to a fixed angle with respect to the current pulse. Application of current pulses along different bars can switch the AFM order between multiple directions. Standard resistance measurements can detect the orientation of the AFM order as high or low resistance states. The state of the device can be set by the input current pulses, and read-out by the resistance measurement, forming a non-volatile, AFM memory storage bit.
FILED	Friday, July 24, 2020
APPL NO	16/938089
ART UNIT	2827 — Semiconductors/Memory
CURRENT CPC	Static Stores G11C 11/1673 (20130101) G11C 13/0004 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/02 (20130101) H01L 43/08 (20130101) H01L 43/10 (20130101) H01L 45/141 (20130101) Original (OR) Class H01L 45/1253 (20130101)
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11342526 — Hybrid organic light emitting device

US 11342526	Forrest et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan); The University of Southern California (Los Angeles, California)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Stephen R. Forrest (Ann Arbor, Michigan); Chan Ho Soh (Ann Arbor, Michigan); Mark E. Thompson (Anaheim, California); Muazzam Idris (Los Angeles, California)
ABSTRACT	An OLED device comprises an anode and a cathode, and at least one graded emissive layer disposed between the anode and the cathode, the graded emissive layer comprising first and second materials, wherein a concentration of the first material increases continuously from an anode side of the graded emissive layer to a cathode side of the graded emissive layer, and a concentration of the second material decreases continuously from the anode side of the graded emissive layer to the cathode side of the graded emissive layer. An OLED device comprising a graded emissive layer and a hybrid white OLED device are also described.
FILED	Friday, January 17, 2020
APPL NO	16/745851
ART UNIT	2812 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/504 (20130101) Original (OR) Class H01L 51/5016 (20130101) H01L 2251/5346 (20130101)
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11342549 — Method for forming sulfur-containing electrode using salt additive

US 11342549	Chen et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
ASSIGNEE(S)	GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan)
INVENTOR(S)	Shuru Chen (Troy, Michigan); Fang Dai (Troy, Michigan); Mei Cai (Bloomfield Hills, Michigan)
ABSTRACT	The present disclosure relates to sulfur-containing electrodes and methods for forming the same. For example, the method may include disposing an electroactive material on or near a current collector to form an electroactive material layer having a first porosity and applying pressure and heat to the electroactive material layer so that the electroactive material layer has a second porosity. The first porosity is greater than the second porosity. The electroactive material may include a plurality of electroactive material particles and one or more salt additives. The method may further include contacting the electroactive material layer and an electrolyte such that the electrolyte dissolves the plurality of one or more salt particles so that the electroactive material layer has a third porosity. The third porosity may be greater than the second porosity and less than the first porosity.
FILED	Wednesday, January 15, 2020
APPL NO	16/743650
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/62 (20130101) H01M 4/139 (20130101) Original (OR) Class H01M 4/0404 (20130101) H01M 4/0435 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101)
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11342564 — Three-dimensional architectured anode, a direct carbon fuel cell including the three-dimensional architectured anode, and related methods

US 11342564	Ding et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) Idaho National Laboratory (INL) Federally Funded Research and Development Center (FFRDC) Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)	Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
INVENTOR(S)	Dong Ding (Idaho Falls, Idaho); Ting He (Idaho Falls, Idaho); Wei Wu (Idaho Falls, Idaho)
ABSTRACT	A method of fabricating a three-dimensional (3D) architectured anode. The method comprises immersing a fabric textile in a precursor solution, the precursor solution comprising a nickel salt and gadolinium doped ceria (GDC). The nickel salt and GDC are absorbed to the fabric textile. The fabric textile comprising the absorbed nickel salt and GDC is removed from the precursor solution and calcined to form a 3D architectured anode comprising nickel oxide and GDC. Additional methods and a direct carbon fuel cell including the 3D architectured anode are also disclosed.
FILED	Wednesday, July 18, 2018
APPL NO	16/629253
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8885 (20130101) H01M 4/9025 (20130101) Original (OR) Class H01M 4/9066 (20130101) H01M 8/141 (20130101) H01M 8/0232 (20130101) H01M 8/1233 (20130101) H01M 8/1246 (20130101) H01M 2008/147 (20130101) H01M 2300/0074 (20130101)
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11342567 — High energy density redox flow device

US 11342567	Chiang et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Massachusetts Institute of Technology (Cambridge, Massachusetts); 24M Technologies, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S)	Yet-Ming Chiang (Weston, Massachusetts); William Craig Carter (Jamaica Plain, Massachusetts); Mihai Duduta (Somerville, Massachusetts); Pimpa Limthongkul (Boston, Massachusetts)
ABSTRACT	Redox flow devices are described including a positive electrode current collector, a negative electrode current collector, and an ion-permeable membrane separating said positive and negative current collectors, positioned and arranged to define a positive electroactive zone and a negative electroactive zone; wherein at least one of said positive and negative electroactive zone comprises a flowable semi-solid composition comprising ion storage compound particles capable of taking up or releasing said ions during operation of the cell, and wherein the ion storage compound particles have a polydisperse size distribution in which the finest particles present in at least 5 vol % of the total volume, is at least a factor of 5 smaller than the largest particles present in at least 5 vol % of the total volume.
FILED	Friday, January 18, 2019
APPL NO	16/252088
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/64 (20190201) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/0206 (20130101) H01M 8/0215 (20130101) H01M 8/0221 (20130101) H01M 8/0228 (20130101) H01M 8/0234 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101)
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11342573 — Ion-imbibed membranes based on proton conducting aromatic polyether type copolymers and their application in redox flow batteries

US 11342573	Paloumbis et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Advent Technologies Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)	ADVENT TECHNOLOGIES INC. (Boston, Massachusetts)
INVENTOR(S)	George Paloumbis (Patras, Greece); Christos L. Chochos (Athens, Greece); Emory Sayre De Castro (Nahant, Massachusetts); Nora Gourdoupi (Patras, Greece); Ryan Pavlicek (Roslindale, Massachusetts); Manav Sharma (Medford, Massachusetts); Vasilis G. Gregoriou (Drosia Attica, Greece)
ABSTRACT	The present invention relates to a class of polymer ion imbibed membranes for electrolyte flow batteries. The membranes are a conducting aromatic polyether type copolymer bearing nitrogen heterocycles groups, especially pyridine type. While the membranes can be used in acid, basic, and neutral electrolytes, the nitrogen heterocycles in the membrane interact with acid in the electrolyte to form a proton transport network, so as to keep the proton transport performance of the membrane. The membrane has excellent mechanical stability and thermostability as well as tunable porosity.
FILED	Monday, March 02, 2020
APPL NO	16/806002
ART UNIT	1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/1027 (20130101) H01M 8/1032 (20130101)
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11342723 — Counter pumping a large mode area fiber laser

US 11342723	Sipes, Jr.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
ASSIGNEE(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
INVENTOR(S)	Donald Lee Sipes, Jr. (Colorado Springs, Colorado)
ABSTRACT	A fiber optic assembly includes: a gain fiber configured to output signal light; a first taper configured to expand the signal light output by the gain fiber; and a reversing prism configured to receive counter-pumping light and output the counter-pumping light into the first taper. The first taper is further configured to direct the counter-pumping light towards the gain fiber.
FILED	Tuesday, July 16, 2019
APPL NO	16/513191
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0621 (20130101) H01S 3/2333 (20130101) H01S 3/06745 (20130101) H01S 3/06754 (20130101) H01S 3/09415 (20130101) H01S 3/094003 (20130101) H01S 3/094053 (20130101) Original (OR) Class
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11343088 — Systems and methods for quantum optical device authentication

US 11343088	Soh et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	Daniel Beom Soo Soh (Pleasanton, California); Scott E. Bisson (Livermore, California)
ABSTRACT	Quantum optical device authentication technologies are described herein. A first device includes an optical transmitter transmits a plurality of pulses to an optical receiver included on a second device. The optical pulses each have one of two non-orthogonal optical states. The optical receiver measures each of the pulses and the second device records a measured value of the optical state of each pulse. Subsequently, the second device transmits the measured values of the optical states of the pulses to the first device. The first device outputs an indication of whether the second device is authenticated based upon the measured values received from the second device and the optical states of the pulses transmitted by the optical transmitter.
FILED	Tuesday, October 01, 2019
APPL NO	16/590003
ART UNIT	2636 — Optical Communications
CURRENT CPC	Electric Digital Data Processing G06F 7/588 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Transmission H04B 10/61 (20130101) H04B 10/70 (20130101) H04B 10/503 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) Original (OR) Class
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11343900 — Thin-film target for DT neutron production

US 11343900	Wampler et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S)	William R. Wampler (Albuquerque, New Mexico); Barney L. Doyle (Albuquerque, New Mexico); Clark S. Snow (Albuquerque, New Mexico)
ABSTRACT	A novel thin-film target can the life of tritium targets for the production of 14 MeV neutrons by the ³H(²H,n)⁴He nuclear reaction while using only a small fraction of the amount of tritium compared to a standard thick-film target. With the thin-film target, the incident deuterium is implanted through the front tritide film into the underlying substrate material. A thin permeation barrier layer between the tritide film and substrate reduces the rate of tritium loss from the tritide film. As an example, good thin-film target performance was achieved using W and Fe for the barrier and substrate materials, respectively.
FILED	Thursday, July 16, 2020
APPL NO	16/930514
ART UNIT	3619 — Multiplex and VoIP
CURRENT CPC	Conversion of Chemical Elements; Radioactive Sources G21G 4/02 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/06 (20130101) H05H 6/00 (20130101) Original (OR) Class
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National Science Foundation (NSF)

11337924 — Targeted polymerized nanoparticles for cancer treatment

US 11337924	Nagy et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana)
ASSIGNEE(S)	Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana)
INVENTOR(S)	Jon O. Nagy (Bozeman, Montana); Tim Triche (Los Angeles, California); Hyung-Gyoo Kang (Buena Park, California)
ABSTRACT	The invention relates to a novel drug delivery vehicle. Various embodiments of the invention provide a hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and non-polymerizable lipids. Therapeutic agents can be loaded into the polymerized liposomal nanoparticle and targeting agents can be conjugated to the surface of the polymerized liposomal nanoparticle. Also described in the invention are methods, compositions and kits that utilize the hybrid polymerized liposomal nanoparticle to treat disease conditions such as various cancers.
FILED	Tuesday, June 18, 2019
APPL NO	16/444842
ART UNIT	1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/1271 (20130101) A61K 9/1273 (20130101) Original (OR) Class A61K 31/136 (20130101) A61K 31/136 (20130101) A61K 31/337 (20130101) A61K 31/337 (20130101) A61K 31/407 (20130101) A61K 31/407 (20130101) A61K 31/475 (20130101) A61K 31/475 (20130101) A61K 31/573 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/713 (20130101) A61K 31/4745 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 31/7068 (20130101) A61K 33/24 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101)
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11338048 — Apparatus for irradiation

US 11338048	Harris et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	AquiSense Technologies LLC (Walton, Kentucky)
ASSIGNEE(S)	AQUISENSE TECHNOLOGIES LLC (Erlanger, Kentucky)
INVENTOR(S)	Theodore Robert Harris (Charlotte, North Carolina); Jennifer Godwin Pagan (Charlotte, North Carolina); Paolo Batoni (Charlotte, North Carolina); John Robert Krause (Charlotte, North Carolina)
ABSTRACT	An irradiation apparatus configured to be coupled to an irradiation chamber containing a material to be irradiated, comprising: a support structure; one or more radiation sources coupled to the support structure; and a heat exchange mechanism thermally coupled to the one or more radiation sources. The heat exchange mechanism comprises one or more of a thermoelectric cooling device, a vapor chamber, a heatsink, a heat dissipation structure, a fan, and a cooling coating. The one or more radiation sources comprise one or more UV radiation sources, one or more UV-C radiation sources, one or more visible radiation sources, or a combination thereof. Optionally, the one or more radiation sources comprise a plurality of radiation sources arranged in an array. Optionally, the one or more radiation sources deliver a combination of wavelengths to the material to be irradiated.
FILED	Wednesday, December 11, 2013
APPL NO	14/102969
ART UNIT	1799 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/16 (20130101) A61L 2/084 (20130101) Original (OR) Class A61L 9/20 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/325 (20130101) C02F 2305/10 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11338087 — Hierarchical adaptive closed-loop fluid resuscitation and cardiovascular drug administration system

US 11338087	Gholami
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	Autonomous Healthcare, Inc. (Hoboken, New Jersey)
ASSIGNEE(S)	Autonomous Healthcare, Inc. (Hoboken, New Jersey)
INVENTOR(S)	Behnood Gholami (Hoboken, New Jersey)
ABSTRACT	The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.
FILED	Thursday, November 05, 2020
APPL NO	17/090729
ART UNIT	3686 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation
CURRENT CPC	Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/3569 (20130101) A61M 2230/00 (20130101) A61M 2230/06 (20130101) A61M 2230/30 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/63 (20180101)
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11338290 — Sorting biological and non-biological moieties using magnetic levitation

US 11338290	Baday et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Human Genome Research Institute (NHGRI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)	The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S)	Murat Baday (Menlo Park, California); Naside Gozde Durmus (Palo Alto, California); Semih Calamak (Palo Alto, California); Utkan Demirci (Stanford, California); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (San Francisco, California); Jaeyoung Yang (Palo Alto, California); Thiruppathiraja Chinnasamy (Mountain View, California); Alessandro Tocchio (San Francisco, California)
ABSTRACT	Systems and methods for levitating populations of moieties, cells, or other such units using one or more magnets in a microfluidic environment are provided. These systems and methods may be used to, for example, separate or sort heterogeneous populations of the units from one another, to assembly a multi-unit assembly during the levitating of the units, and to evaluate samples at the point of care in real-time. These systems and methods may also utilize a frame that enables an imaging device, such as a smartphone, to capture the units in real time as they are manipulated in the system.
FILED	Friday, September 30, 2016
APPL NO	15/764017
ART UNIT	1759 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 3/502784 (20130101) B01L 2200/0652 (20130101) B01L 2300/0864 (20130101) B01L 2400/043 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/574 (20130101) G01N 33/4875 (20130101) G01N 33/54366 (20130101) G01N 33/56966 (20130101) G01N 2015/1486 (20130101) Image Data Processing or Generation, in General G06T 7/0016 (20130101) G06T 2207/30101 (20130101) G06T 2207/30242 (20130101) G06T 2211/428 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101)
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11339094 — Mitigation of alkali-silica reaction in concrete using readily-soluble chemical additives

US 11339094	Sant et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); YARA INTERNATIONAL ASA (Oslo, Norway); CONSTRUCTION RESEARCH and TECHNOLOGY GMBH (Trostberg, Germany)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); Yara International ASA (Oslo, Norway); CONSTRUCTION RESEARCH and TECHNOLOGY GMBH (Trostberg, Germany)
INVENTOR(S)	Gaurav N. Sant (Los Angeles, California); Gabriel D. Falzone (Los Angeles, California); Tandre Oey (Los Angeles, California); Wolfram Franke (Los Angeles, California); Paul Seiler (Los Angeles, California); Erika Callagon La Plante (Los Angeles, California)
ABSTRACT	A manufacturing method includes: (1) incorporating at least one soluble, calcium, magnesium, or other divalent cation-containing additive into a concrete mixture including aggregates prone to alkali-silica reaction; and (2) curing the concrete mixture to form a concrete product.
FILED	Monday, August 13, 2018
APPL NO	16/638720
ART UNIT	1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/06 (20130101) C04B 14/22 (20130101) C04B 20/1074 (20130101) C04B 22/085 (20130101) Original (OR) Class C04B 22/124 (20130101) C04B 28/02 (20130101) C04B 2103/603 (20130101) C04B 2111/2023 (20130101)
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11339104 — Process for upgrading natural gas liquids from shale gas without front-end demethanizer

US 11339104	Agrawal et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
ASSIGNEE(S)	PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S)	Rakesh Agrawal (West Lafayette, Indiana); Yiru Li (West Lafayette, Indiana)
ABSTRACT	Processes and systems for upgrading natural gas liquids. At least a portion of the natural gas liquid components in a shale gas stream can be dehydrogenated to their corresponding olefin derivatives prior to separating any methane from the liquids. Further processing subsequent to dehydrogenation could include various separations, oligomerizing olefins produced in the dehydrogenation step, recovering desired products, etc. The order of the processing steps subsequent to dehydrogenation could be adjusted in various cases.
FILED	Friday, March 27, 2020
APPL NO	16/831993
ART UNIT	1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC	Acyclic or Carbocyclic Compounds C07C 2/06 (20130101) C07C 5/333 (20130101) Original (OR) Class C07C 11/02 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 5/00 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/102 (20130101) C10L 3/106 (20130101)
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11339268 — One-step, solvent-free method for recycling and reprocessing thermoset polymers with tunable properties

US 11339268	Manas-Zloczower et al.
FUNDED BY	National Science Foundation (NSF) Office of International Science and Engineering (OISE)
APPLICANT(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)	CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S)	Ica Manas-Zloczower (Cleveland, Ohio); Liang Yue (Cleveland, Ohio)
ABSTRACT	Thermosetting plastics are recycled by process that begins with grinding the plastic into small pieces. This particulate is then mixed with a catalyst and ball mill milled to a fine powder, which can then be reprocessed via molding (e.g., hot-press, injection, etc.).
FILED	Thursday, July 30, 2020
APPL NO	16/942935
ART UNIT	1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC	Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) Original (OR) Class C08J 11/24 (20130101) C08J 2363/00 (20130101) C08J 2401/02 (20130101)
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11339363 — Dendritic cell generating apparatus and method

US 11339363	Kozbial
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	FLASKWORKS, LLC (Newton, Massachusetts)
ASSIGNEE(S)	FLASKWORKS, LLC (Boston, Massachusetts)
INVENTOR(S)	Andrew Kozbial (East Boston, Massachusetts)
ABSTRACT	A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge.
FILED	Monday, April 06, 2020
APPL NO	16/841197
ART UNIT	1799 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 23/34 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) C12M 41/00 (20130101) C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 2506/115 (20130101)
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11339413 — Compositions and methods for robust dynamic metabolic control of 3-hydroxypropionic acid production

US 11339413	Lynch et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S)	Michael David Lynch (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina)
ABSTRACT	The present disclosure provides compositions and methods for rapid production of chemicals in genetically engineered microorganisms in a large scale. Also provided herein is a high-throughput metabolic engineering platform enabling the rapid optimization of microbial production strains. The platform, which bridges a gap between current in vivo and in vitro bio-production approaches, relies on dynamic minimization of the active metabolic network.
FILED	Wednesday, October 23, 2019
APPL NO	16/661085
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) C12N 9/0008 (20130101) C12N 9/0016 (20130101) C12N 9/0051 (20130101) C12N 9/1025 (20130101) C12N 15/746 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class C12P 13/06 (20130101)
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11339470 — Diamond nanofibers and methods of making diamond nanofibers and large-size diamonds

US 11339470	Narayan
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)	North Carolina State University (Raleigh, North Carolina)
INVENTOR(S)	Jagdish Narayan (Raleigh, North Carolina)
ABSTRACT	The present disclosure provides methods for forming diamond nanostructures and diamonds from amorphous carbon nanostructures in ambient temperature and pressure by irradiating carbon nanostructures to an undercooled state and quenching the melted carbon to convert a portion of the nanostructure into diamond.
FILED	Friday, November 08, 2019
APPL NO	16/677999
ART UNIT	1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/0209 (20130101) Original (OR) Class C23C 16/271 (20130101)
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11340024 — Manufacturable metal-graphene interface for highly efficient and durable heat exchanger components

US 11340024	Li et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S)	UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina)
ASSIGNEE(S)	University of South Carolina (Columbia, South Carolina)
INVENTOR(S)	Chen Li (Chapin, South Carolina); Wei Chang (Columbia, South Carolina); Benli Peng (Columbia, South Carolina); Pengtao Wang (Columbia, South Carolina)
ABSTRACT	The present disclosure relates to efficient heat exchanger components, such as pipe apparatuses including the same. Methods of fabricating heat exchange components are also disclosed. A condensing apparatus can include a condenser surface having a substrate and one or more layers of graphene. The substrate can be formed of nickel and a nickel-graphene surface composite layer can be formed. The substrate-graphene composite can be highly durable, hydrophobic, and resistant to fouling. Dropwise condensation can be induced.
FILED	Tuesday, September 24, 2019
APPL NO	16/580249
ART UNIT	3763 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC	Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 2339/04 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/02 (20130101) F28F 21/089 (20130101) F28F 2245/02 (20130101)
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11340057 — Systems and methods for interferometric multifocus microscopy

US 11340057	He et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR) Department of Energy (DOE) Office of Science (DOE-SC) Argonne National Laboratory (ANL) Federally Funded Research and Development Center (FFRDC) Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Information and Intelligent Systems (IIS)
APPLICANT(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)	Northwestern University (Evanston, Illinois); UChicago Argonne, LLC (Chicago, Illinois); The University of Chicago (Chicago, Illinois)
INVENTOR(S)	Kuan He (Cupertino, California); Oliver Strider Cossairt (Evanston, Illinois); Aggelos K. Katsaggelos (Chicago, Illinois); Norbert Scherer (Chicago, Illinois); Mark Hereld (Chicago, Illinois)
ABSTRACT	A system to generate image representations includes a first objective that receives a first light beam emitted from a sample and a second objective that receives a second light beam emitted from the sample, where the first light beam and the second light beam have conjugate phase. The system also includes a first diffractive element to receive the first light beam and separate it into a first plurality of diffractive light beams that are spatially distinct, and a second diffractive element to receive the second light beam and separate it into a second plurality of diffractive light beams that are spatially distinct. The system further includes a detector that receives the first and second plurality of diffractive light beams. The first plurality of diffractive light beams and the second plurality of diffractive light beams are simultaneously directed and focused onto different portions of an image plane of the detector.
FILED	Friday, June 21, 2019
APPL NO	15/734172
ART UNIT	2886 — Optics
CURRENT CPC	Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/04 (20130101) Original (OR) Class G01B 9/02041 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4788 (20130101) Optical Elements, Systems, or Apparatus G02B 21/361 (20130101)
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11340164 — Fluorescent method to quantify copper or platinum based on catalysis

US 11340164	Koide et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Kazunori Koide (Pittsburgh, Pennsylvania); Melissa L. Campbell (Pittsburgh, Pennsylvania); Dianne Pham (Pittsburgh, Pennsylvania)
ABSTRACT	Methods of detecting platinum and copper in a test sample are provided. Kits for use in detecting platinum and copper in a test sample also are provided.
FILED	Thursday, April 11, 2019
APPL NO	16/381504
ART UNIT	1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 21/6428 (20130101) Original (OR) Class G01N 33/20 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/16 (20150115)
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11340189 — Electrochemical impedimetric biosensing microchip for real time telomerase activity detection

US 11340189	Cabrera et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	Carlos Raul Cabrera (San Juan, Puerto Rico); Lisandro Federico Cunei (San Juan, Puerto Rico); Carlos I. Gonzalez (Trujillo Alto, Puerto Rico); Marina Martinez-Vargas (Naguabo, Puerto Rico)
ASSIGNEE(S)	University of Puerto Rico (San Juan, Puerto Rico)
INVENTOR(S)	Carlos Raul Cabrera (San Juan, Puerto Rico); Lisandro Federico Cunei (San Juan, Puerto Rico); Carlos I. Gonzalez (Trujillo Alto, Puerto Rico); Marina Martinez-Vargas (Naguabo, Puerto Rico)
ABSTRACT	The enzyme telomerase is present at about 85% of human cancers that makes it not only an excellent target for cancer treatment but also an excellent marker for cancer detection. Using a single stranded DNA probe specific for telomerase binding and reverse transcription tethered to an interdigital gold electrode array surface, the chromosome protection provided by the telomerase was replicated and followed by Electrochemical Impedance Spectroscopy as an unlabeled biosensor. Using a custom system, which is simple and affordable, the impedance measurements were taken while incubating at 37° C. and promoting the probe elongation. This resulted in up to 14-fold increase in the charge transfer resistance when testing a telomerase-positive nuclear extract from Jurkat cells compared to the heat-inactivated telomerase-negative nuclear extract. The electron transfer process at the Au electrodes was studied before and after the elongation, after 4 months in contact with the telomerase-positive nuclear extract, and after desorption of the non-specific bindings.
FILED	Monday, November 30, 2015
APPL NO	14/954376
ART UNIT	1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Enzymes C12Y 207/07049 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3275 (20130101) Original (OR) Class G01N 33/573 (20130101) G01N 2333/912 (20130101)
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11340271 — Forced oscillation source location determination based on oscillation mode angle analysis using synchrophasor data

US 11340271	Liu et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S)	Yilu Liu (Knoxville, Tennessee); Weikang Wang (Knoxville, Tennessee); Wenpeng Yu (Knoxville, Tennessee); Chujie Zeng (Knoxville, Tennessee); Lin Zhu (Knoxville, Tennessee)
ABSTRACT	A method includes performing by a processor: receiving a plurality of synchrophasor measurements of a power system signal associated with a time interval from a plurality of phasor measurement units (PMUs), respectively, each of the plurality of synchrophasor measurements including a phase angle, frequency value, and a timestamp associated with the synchrophasor measurement; determining, for each of the plurality of PMUs, a dominant mode frequency of a forced oscillation signal component of the power system signal based on the frequency value and the phase angle; determining, for each of the plurality of PMUs, a mode angle of the forced oscillation signal component at the dominant mode frequency; and determining a geographic forced oscillation source location for a source of the forced oscillation signal component based on the plurality of mode angles associated with each of the plurality of PMUs, respectively, and geographic locations of the plurality of PMUs.
FILED	Friday, July 31, 2020
APPL NO	16/947410
ART UNIT	2852 — Printing/Measuring and Testing
CURRENT CPC	Measuring Electric Variables; Measuring Magnetic Variables G01R 19/2513 (20130101) Original (OR) Class G01R 29/18 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/24 (20130101)
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11340514 — Tunable robust topological source of indistinguishable correlated photon pairs

US 11340514	Mittal et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Air Force Research Laboratory (AFRL) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Department of the Navy (DON) Office of Naval Research (ONR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Physics (PHY)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland)
INVENTOR(S)	Sunil Mittal (Rockville, Maryland); Mohammad Hafezi (Washington, District of Columbia); Venkata Vikram Orre (College Park, Maryland); Elizabeth Goldschmidt (Urbana, Illinois)
ABSTRACT	A topological photonic system configured as a robust source of indistinguishable photons pairs with tunable spectral correlations. The system includes a two-dimensional silicon-photonic ring resonator array configured to implement an anomalous-quantum Hall model that exhibits topologically robust edge states. Linear dispersion of the edge states ensures efficient and robust phase matching and tunability of the spectral bandwidth of photon pairs generated via spontaneous four-wave mixing. Spectral tunability is manifested in the temporal correlations in the Hong-Ou-Mandel interference between photons. The generated photon pairs are energy-time entangled.
FILED	Friday, May 21, 2021
APPL NO	17/326971
ART UNIT	2874 — Optics
CURRENT CPC	Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3526 (20130101) Original (OR) Class G02F 1/3536 (20130101)
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11341283 — Learning guided obfuscation framework for hardware IP protection

US 11341283	Alaql et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS) Directorate for Education and Human Resources (EHR) Division of Graduate Education (DGE)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Abdulrahman Alaql (Gainesville, Florida); Saranyu Chattopadhyay (Gainesville, Florida); Swarup Bhunia (Gainesville, Florida); Prabuddha Chakraborty (Gainesville, Florida)
ABSTRACT	Embodiments of the present disclosure provide methods, apparatus, systems, computer program products, computing devices, and/or computing entities for obfuscating a hardware intellectual property (IP) design by locking the design based at least in part on a plurality of key-bits. In one embodiment, a method is provided comprising: generating a key vulnerability matrix for a locked version of the design and a plurality of attacks that comprises for each attack, a vector comprising a value for each key-bit identifying whether the attack successfully extracted a correct key value for the key-bit; and for each key-bit: determining whether the key-bit is vulnerable to an attack based on the values in the matrix; and responsive to being vulnerable: identifying a set of solutions to mitigate the attack; selecting a solution from the set; and inserting a key-gate type for the key-bit at a location identified by the selected solution into the design.
FILED	Monday, November 23, 2020
APPL NO	17/101153
ART UNIT	2492 — Cryptography and Security
CURRENT CPC	Electric Digital Data Processing G06F 21/75 (20130101) Original (OR) Class
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11342176 — Integrated electrohydrodynamic jet printing and spatial atomic layer deposition system for area selective-atomic layer deposition

US 11342176	Rose et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S)	Mattison Rose (Ann Arbor, Michigan); Kira Barton (Ann Arbor, Michigan); Neil Dasgupta (Ann Arbor, Michigan); Lauren Ransohoff (Brookline, Massachusetts); Ellis Herman (Cambridge, Massachusetts); Orlando Trejo (Ann Arbor, Michigan); Carli Huber (Norwalk, Connecticut); Tae H. Cho (Ann Arbor, Michigan); Eric Kazyak (Ann Arbor, Michigan); Christopher P. Pannier (Ann Arbor, Michigan)
ABSTRACT	An integrated electrohydrodynamic jet printing and spatial atomic layer deposition system for conducting nanofabrication includes an electrohydrodynamic jet printing station that includes an E-jet printing nozzle, a spatial atomic layer deposition station that includes a zoned ALD precursor gas distributor that discharges linear zone-separated first and second ALD precursor gases, a heatable substrate plate supported on a motion actuator controllable to move the substrate plate in three dimensions, and a conveyor on which the motion actuator is supported. The conveyor is operative to move the motion actuator between the electrohydrodynamic jet printing station and the spatial atomic layer deposition station so that the substrate plate is conveyable between a printing window of the E-jet printing nozzle and a deposition window of the zoned ALD precursor gas distributor, respectively. A method of conducting area-selective atomic layer deposition is also disclosed.
FILED	Thursday, July 23, 2020
APPL NO	16/937496
ART UNIT	1716 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC	Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/06 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) C23C 16/54 (20130101) C23C 16/45544 (20130101) C23C 16/45551 (20130101) C23C 16/45553 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) Original (OR) Class H01L 21/02288 (20130101)
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11342438 — Device with heteroepitaxial structure made using a growth mask

US 11342438	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Cudjoe Key, Florida); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Wednesday, October 17, 2018
APPL NO	16/162787
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342441 — Method of forming a seed area and growing a heteroepitaxial layer on the seed area

US 11342441	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Tuesday, January 21, 2020
APPL NO	16/747765
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342442 — Semiconductor product comprising a heteroepitaxial layer grown on a seed area of a nanostructured pedestal

US 11342442	Brueck et al.
FUNDED BY	Department of Defense (DOD) Defense Threat Reduction Agency (DTRA) National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Steven R. J. Brueck (Albuquerque, New Mexico); Stephen D. Hersee (Albuquerque, New Mexico); Seung-Chang Lee (Albuquerque, New Mexico); Daniel Feezell (Albuquerque, New Mexico)
ABSTRACT	A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.
FILED	Tuesday, January 21, 2020
APPL NO	16/748095
ART UNIT	2897 — Semiconductors/Memory
CURRENT CPC	Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) B82Y 40/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02107 (20130101) H01L 21/02381 (20130101) H01L 21/02532 (20130101) H01L 21/02538 (20130101) H01L 21/02639 (20130101) H01L 27/1211 (20130101) H01L 29/04 (20130101) H01L 29/16 (20130101) H01L 29/20 (20130101) H01L 29/045 (20130101) H01L 29/0665 (20130101) H01L 29/0673 (20130101) H01L 29/0676 (20130101) H01L 29/775 (20130101) H01L 29/785 (20130101) H01L 29/7783 (20130101) H01L 29/7827 (20130101) H01L 29/7851 (20130101) H01L 29/66462 (20130101) Original (OR) Class H01L 29/66469 (20130101) H01L 29/66666 (20130101) H01L 29/66795 (20130101)
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11342615 — Electrochemical cell cap

US 11342615	Davies et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology, Innovation and Partnerships (TIP) Translational Impacts (TI)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California); South 8 Technologies, Inc. (San Diego, California)
INVENTOR(S)	Daniel Davies (San Diego, California); Cyrus Sam Rustomji (San Diego, California); Yangyuchen Yang (La Jolla, California); Jungwoo Lee (San Diego, California); Ying Shirley Meng (San Diego, California)
ABSTRACT	Methods, systems, and apparatuses are described for implementing electrochemical energy storage devices using a liquefied gas electrolyte. The mechanical designs of an electrochemical device to house a liquefied gas electrolyte as well as methods of filling and sealing said device are presented.
FILED	Monday, October 28, 2019
APPL NO	16/666155
ART UNIT	1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/60 (20130101) H01G 11/62 (20130101) H01G 11/64 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/02 (20130101) H01M 10/0569 (20130101) H01M 50/147 (20210101) Original (OR) Class H01M 50/172 (20210101) H01M 50/183 (20210101)
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11342740 — Drain current sensing and fault protection circuit based on gate voltage for gate current driven field effect transistors

US 11342740	Wang et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Engineering Education and Centers (EEC)
APPLICANT(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)	University of Tennessee Research Foundation (Knoxville, Tennessee)
INVENTOR(S)	Fei Wang (Knoxville, Tennessee); Edward A. Jones (Knoxville, Tennessee)
ABSTRACT	A power converter circuit includes a switch including a field effect transistor, the field effect transistor being a wide bandgap field effect transistor and being configured to maintain an on operational state responsive to a maintenance signal received through a gate terminal, a current sensing circuit that is configured to estimate a drain terminal current of the field effect transistor responsive to a voltage between the gate terminal of the field effect transistor and a source terminal of the field effect transistor, and a gate driving circuit that is configured to generate the maintenance signal responsive to the estimate of the drain terminal current.
FILED	Friday, June 22, 2018
APPL NO	16/016166
ART UNIT	2839 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/1066 (20130101) H01L 29/2003 (20130101) H01L 29/7787 (20130101) H01L 29/41766 (20130101) Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 7/122 (20130101) H02H 7/125 (20130101) H02H 7/1213 (20130101) Original (OR) Class Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 1/0009 (20210501) H02M 1/32 (20130101)
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11343278 — Apparatus and method for protecting location privacy of cooperative spectrum sensing users

US 11343278	Grissa et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	Oregon State University (Corvallis, Oregon)
ASSIGNEE(S)	Oregon State University (Corvallis, Oregon)
INVENTOR(S)	Mohamed Grissa (Corvallis, Oregon); Atilla Yavuz (Corvallis, Oregon); Bechir Hamdaoui (Corvallis, Oregon)
ABSTRACT	An apparatus is provided which comprises: logic to privately compare one or more received Order Preserving Encrypted (OPE) signal strength (RSS) values, from a plurality of secondary users (SUs), with a OPE threshold value; a transmitter to send the comparison result to a fusion center (FC); and a receiver to receive the OPE threshold value from the FC.
FILED	Thursday, February 06, 2020
APPL NO	16/784180
ART UNIT	2467 — Multiplex and VoIP
CURRENT CPC	Transmission H04B 17/318 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/162 (20130101) Original (OR) Class Wireless Communication Networks H04W 12/02 (20130101) H04W 12/03 (20210101) H04W 12/04 (20130101) H04W 16/14 (20130101) H04W 74/002 (20130101) H04W 74/0816 (20130101) H04W 88/16 (20130101)
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Department of Agriculture (USDA)

11337391 — Early flowering plants

US 11337391	Marks et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)	Regents of the University of Minnesota (Minneapolis, Minnesota)
INVENTOR(S)	Michael David Marks (Roseville, Minnesota); Kevin Dorn (Roseville, Minnesota)
ABSTRACT	This document relates to materials and methods for generating early flowering oilseed (e.g., pennycress) plants. For example, oilseed plants (e.g., modified oilseed plants) having one or more modifications in a polypeptide involved in early flowering (e.g., early flowering six (ELF6)), as well as materials and methods for making and using early flowering oilseed plants are provided.
FILED	Friday, August 17, 2018
APPL NO	16/104318
ART UNIT	1663 — Plants
CURRENT CPC	New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 5/02 (20130101) A01H 5/10 (20130101) A01H 6/20 (20180501) Original (OR) Class Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101)
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11337432 — Automated crab meat picking system and method

US 11337432	Tao et al.
FUNDED BY	Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland)
ASSIGNEE(S)	University of Maryland, College Park (College Park, Maryland)
INVENTOR(S)	Yang Tao (North Potomac, Maryland); Robert Vinson (Rockville, Maryland); Dongyi Wang (College Park, Maryland); Maxwell Holmes (Washington, District of Columbia); Gary E. Seibel (Westminster, Maryland)
ABSTRACT	A vision guided intelligent system for automated crab meat picking operates in a fully automated or semi-automatic modes of operation using a crab meat picking routine based on (a) the CNN model localization of back-fin knuckles algorithm, and/or (b) the Deep Learning model which accurately locates not only knuckle positions, but also crab legs and crab cores, with a high pixel accuracy (up to 0.9843), and low computation time. The subject system uses a concept of analyzing crab morphologies obtained from digital crab images, and, using a Deep Learning architecture integrated in the system, segments crab images into five regions of interest in a single step with high accuracy and efficiency. The image segmentation results are used for generating crab cut lines in XYZ and angular directions, determining starting cutting points in Z plane, and guiding cutting tools and end effectors to automatically cut crabs and harvest crab meat.
FILED	Wednesday, April 03, 2019
APPL NO	16/373979
ART UNIT	3643 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Processing Meat, Poultry, or Fish A22C 29/023 (20130101) Original (OR) Class A22C 29/025 (20130101) A22C 29/028 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 17/40 (20160801) Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 35/44 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/78 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101)
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11337446 — Crisp and hard whole oat kernel snack

US 11337446	McHugh et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); POP OATS LLC (Albany, California)
ASSIGNEE(S)	The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia); Pop Oats LLC (Albany, California)
INVENTOR(S)	Tara H. McHugh (Albany, California); Zhongli Pan (El Macero, California); Donald A. Olson (Isleton, California); Marc Pfeiffer (Los Angeles, California); Rodger Morris (Oakland, California)
ABSTRACT	A crisp and hard whole kernel oat snack product made by fully hydrating whole oat kernels (i.e. oat groats), and then gelatinizing the starch in the whole oat kernels using an infrared process. The gelatinized oats are then roasted in a hot air dryer. The resulting food product is measurably harder and crisper than other whole oat products currently available.
FILED	Monday, June 18, 2018
APPL NO	16/010761
ART UNIT	1793 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC	Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 7/148 (20160801) Original (OR) Class A23L 7/1975 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101)
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11338159 — Fire detection in thermal images

US 11338159	Forsyth
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S)	William Forsyth (Boise, Idaho)
ABSTRACT	One or more thermal images containing pixel-by-pixel radiation intensity data in two or more wavelength bands can be processed to accurately determine the location of fire within the image(s), regardless of the radiation-scattering effects of smoke. First, all pixels having radiation intensities above a fire threshold in the longer-wavelength band are classified as being aflame. Second, a threshold curve defining a fire threshold in the shorter-wavelength band is applied to the pixels, and those having radiation intensities above the fire threshold in the shorter-wavelength band are classified as being aflame. Third, at least the second group of pixels above is tested to see if each pixel classified as being aflame is part of a group of adjoining pixels which were all classified as being aflame, and if so, each such pixel is reclassified as not being aflame unless it also falls within the first group of pixels above.
FILED	Wednesday, May 17, 2017
APPL NO	15/597666
ART UNIT	2488 — Recording and Compression
CURRENT CPC	Fire-fighting A62C 3/0271 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6267 (20130101) Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 2207/10032 (20130101) G06T 2207/10048 (20130101) G06T 2207/30181 (20130101)
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11339275 — Compositions and methods for food packaging

US 11339275	Glenn et al.
FUNDED BY	Department of Agriculture (USDA)
APPLICANT(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); World Centric (Petaluma, California)
ASSIGNEE(S)	The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); World Centric (Petaluma, California)
INVENTOR(S)	Gregory M. Glenn (American Canyon, California); Xing Jin (Albany, California)
ABSTRACT	Compositions comprising a fiber component, optionally a dispersing agent operable to disperse the fiber component to create a fiber matrix, a starch component distributed essentially throughout the fiber matrix, and a filler component are disclosed. Methods of forming articles such as containers and packages from such compositions are also disclosed.
FILED	Thursday, September 27, 2018
APPL NO	16/144503
ART UNIT	1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC	Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics B29B 13/02 (20130101) B29B 15/08 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/02 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2003/00 (20130101) B29K 2505/00 (20130101) B29K 2509/02 (20130101) B29K 2509/08 (20130101) B29K 2509/10 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/712 (20130101) Compositions of Macromolecular Compounds C08L 1/286 (20130101) C08L 1/286 (20130101) C08L 3/02 (20130101) Original (OR) Class C08L 3/02 (20130101) C08L 3/02 (20130101) C08L 3/02 (20130101) C08L 29/04 (20130101) C08L 29/04 (20130101) C08L 97/02 (20130101) C08L 97/02 (20130101) C08L 97/02 (20130101)
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11339375 — Paramyxovirus virus-like particles as protein delivery vehicles

US 11339375	Schmitt et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Department of Agriculture (USDA)
APPLICANT(S)	The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)	The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S)	Anthony Paul Schmitt (State College, Pennsylvania); Phuong Tieu Schmitt (State College, Pennsylvania); Greeshma Vivekananda Ray (Cleveland, Ohio)
ABSTRACT	Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting VLPs, and methods for screening for anti-viral compounds using the VLPs. The modified VLPs contain a contiguous recombinant polypeptide that contains i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein. Non-covalent complexes of paramyxovirus M protein and fusion proteins that contain a C-terminal domain of a paramyxovirus nucleocapsid protein and a polypeptide sequence of a distinct protein are provided, as are non-covalent complexes of cells, and cell receptors, with modified VLPs.
FILED	Thursday, June 06, 2019
APPL NO	16/433412
ART UNIT	1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC	Peptides C07K 14/005 (20130101) C07K 14/8121 (20130101) C07K 16/1027 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 9/0069 (20130101) C12N 9/0089 (20130101) C12N 2760/18022 (20130101) C12N 2760/18023 (20130101) C12N 2760/18034 (20130101) C12N 2760/18222 (20130101) C12N 2760/18223 (20130101) C12N 2760/18234 (20130101) C12N 2760/18252 (20130101) C12N 2760/18722 (20130101) C12N 2760/18723 (20130101) C12N 2760/18734 (20130101) Enzymes C12Y 113/12005 (20130101) C12Y 115/01001 (20130101)
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National Aeronautics and Space Administration (NASA)

11339463 — Phase transformation strengthened Ni-based disk superalloy

US 11339463	Smith et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as Represented by the Administrator of National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S)	Timothy M. Smith (Cleveland, Ohio); Robert W. Carter (Cleveland, Ohio)
ABSTRACT	A local phase transformation strengthened nickel-base superalloy includes at least 8.0 wt % eta phase formers; at least 7.0 wt % of chi phase formers; less than 12 wt % chromium; at least 18 wt % cobalt; and aluminum. A ratio of eta phase formers:aluminum is (3.2-3.4):1. The eta phase formers can include titanium, tantalum, hafnium, and niobium. The chi phase formers include tungsten and molybdenum. When the superalloy is subjected to elevated temperatures, these levels of components promote eta and chi phase formation along superlattice stacking faults, thereby resulting in a local phase transformation at the stacking faults, which strengthens the superalloy and inhibits creep deformation.
FILED	Friday, January 31, 2020
APPL NO	16/778033
ART UNIT	1759 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC	Alloys C22C 1/0433 (20130101) C22C 19/056 (20130101) C22C 19/057 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/10 (20130101) Original (OR) Class
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11339674 — Blade retainer for gas turbine engine

US 11339674	Bailey
FUNDED BY	National Aeronautics and Space Administration (NASA) Glenn Research Center (GLENN)
APPLICANT(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
ASSIGNEE(S)	Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S)	Patrick Bailey (Lebanon, Indiana)
ABSTRACT	A blade retainer adapted for use in a gas turbine engine is configured to block axial movement of a blade. The blade retainer includes a first brace, a second brace, and a web that extends between the first brace and the second brace. The blade retainer is configured to block axial movement of a root of the blade out of a blade receiver slot.
FILED	Tuesday, August 14, 2018
APPL NO	16/103419
ART UNIT	3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/282 (20130101) F01D 5/323 (20130101) Original (OR) Class F01D 5/3015 (20130101) Non-positive-displacement Pumps F04D 29/322 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/24 (20130101) F05D 2240/80 (20130101) F05D 2240/90 (20130101) F05D 2260/70 (20130101) F05D 2260/941 (20130101) F05D 2300/603 (20130101)
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11340337 — Two micrometer laser transmitter for 3-D doppler wind lidar for space applications

US 11340337	Singh et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia)
ASSIGNEE(S)	UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA. (Washington, District of Columbia)
INVENTOR(S)	Upendra N Singh (Yorktown, Virginia); Mulugeta Petros (Newport News, Virginia); Tamer F. Refaat (Hampton, Virginia)
ABSTRACT	A laser transmitter assembly for use in a Coherent Doppler Wind Lidar (“CDWL”) system includes a telescope/scanner assembly, a receiver, and a master oscillator crystal and a power amplifier crystal each constructed of Ho:YAG. The crystals are end-pumped to transmit an output beam through the telescope/scanner assembly with a high repetition rate of 200-300 Hz and 35 mJ of energy. As part of the CDWL system, a pump laser end-pumps the master oscillator and power amplifier crystals using a pump beam having a nominal wavelength of 1.905 μm. A seed laser transmits a seeding beam into the master oscillator crystal at a nominal wavelength of 2.0965 μm. The telescope/scanner assembly transmits the generated laser beam through an atmosphere toward a scene of interest, collects a backscattered return signal, and communicates the backscattered return signal to the receiver during operation of the CDWL system.
FILED	Tuesday, December 17, 2019
APPL NO	16/716548
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/117 (20130101) H01S 3/161 (20130101) H01S 3/0405 (20130101) H01S 3/0623 (20130101) H01S 3/1616 (20130101) H01S 3/1643 (20130101) H01S 3/1653 (20130101) H01S 3/2308 (20130101) H01S 3/094038 (20130101) H01S 3/094042 (20130101)
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11340392 — Linear polarization sensitive meta-material reflector and phase modification structure and method

US 11340392	Wollack et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Edward Wollack (Greenbelt, Maryland); Kyle Helson (Columbia, Maryland)
ABSTRACT	The present invention relates to electromagnetic meta-material structures to serve as linear polarization sensitive mirrors. Two distinct classes have been developed, including: 1) a phase cohering reflector which maintains the phase of both polarization states with a controlled delay between polarization states, and 2) a phase de-cohering reflector which preserves the phase of one polarization state and destroys the coherence in the other. These reflective structures enable mitigation of spurious resonances in dual-polarization optical systems and phase compensation between polarization states. These polarization control structures have applications in absorber coupled detectors and receiver systems for space-borne and sub-orbital remote sensing applications.
FILED	Friday, September 27, 2019
APPL NO	16/585612
ART UNIT	2872 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/08 (20130101) G02B 5/3033 (20130101) Original (OR) Class G02B 5/3058 (20130101)
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11343904 — Multi-functional nanomaterial sensor platform

US 11343904	Sultana
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)	United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S)	Mahmooda Sultana (Laurel, Maryland)
ABSTRACT	The present invention relates to a multi-functional platform, including: a printed circuit board (PCB) having a single chip integrated thereon; wherein the single chip includes a substrate having an environmental system disposed thereon, the environmental system including a plurality of three-dimensional (3D) printed, patterned and multi-layered nanostructures disposed on the substrate. The nanostructures include an on-chip heater, a power source, a wireless communication module, and a plurality of sensors, the sensors including at least one of a gas sensor, a pressure sensor, or a temperature sensor, each of which is directly deposited on the substrate and printed with a plurality of nanomaterials. The 3D patterned nanostructures use functionalized nanomaterials, which are patterned by a template using one of directed assembly or nano-offset printing, to deposit the nanostructures directly on the substrate of the single chip.
FILED	Monday, February 22, 2021
APPL NO	17/181102
ART UNIT	2847 — Electrical Circuits and Systems
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/0669 (20130101) Antennas, i.e Radio Aerials H01Q 1/2283 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/118 (20130101) H05K 1/0243 (20130101) Original (OR) Class H05K 1/0284 (20130101) H05K 3/125 (20130101)
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National Security Agency (NSA)

11340410 — Dimensionally all-to-all connected network system using photonic crossbars and quad-node-loop routing

US 11340410	Leigh et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Kevin B. Leigh (Houston, Texas); Luca Ramini (Cernusco sul Naviglio, Italy); Mir Ashkan Seyedi (Milpitas, California); Marco Fiorentino (Milpitas, California)
ABSTRACT	An photonic circuit includes a substrate, a plurality of first light waveguides disposed on the substrate, the first light waveguides extending in a first direction, a plurality of second light waveguides disposed on the substrate and extending in a second direction intersecting the first direction, and a plurality of first micro-ring resonators disposed on the substrate. Each of the first light waveguides has an intersection with each of the second light waveguides. Each of the intersections is provided with a first micro-ring resonator of the first micro-ring resonators. Each first micro-ring resonator is configured to route signals of a respective wavelength from one of the light waveguides at the intersection to another light waveguide at the intersection.
FILED	Monday, October 19, 2020
APPL NO	17/074472
ART UNIT	2883 — Optics
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/4215 (20130101) Original (OR) Class G02B 6/29343 (20130101) Transmission H04B 10/801 (20130101) Selecting H04Q 2011/0009 (20130101) H04Q 2011/0058 (20130101)
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11341369 — Distributed batch normalization using partial populations

US 11341369	Dennison et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	NVIDIA Corporation (Santa Clara, California)
ASSIGNEE(S)	NVIDIA Corporation (Santa Clara, California)
INVENTOR(S)	Larry Robert Dennison (Mendon, Massachusetts); Benjamin Klenk (San Jose, California)
ABSTRACT	A technique for performing data parallel training of a neural network model is disclosed that incorporates batch normalization techniques using partial populations to generate normalization parameters. The technique involves processing, by each processor of a plurality of processors in parallel, a first portion of a sub-batch of training samples allocated to the processor to generate activations for the first portion of the sub-batch. Each processor analyzes the activations and transmits statistical measures for the first portion to an additional processor that reduces the statistical measures from multiple processors to generate normalization parameters for a partial population of the training samples that includes the first portion from each of the plurality of processors. The normalization parameters are then transmitted back to each of the processors to normalize the activations for both the first portion and a second portion of the sub-batch of training samples allocated to each processor.
FILED	Thursday, October 31, 2019
APPL NO	16/669925
ART UNIT	2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC	Electric Digital Data Processing G06F 7/483 (20130101) G06F 9/3885 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Original (OR) Class G06K 9/6265 (20130101) G06K 9/6298 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0481 (20130101)
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11342472 — Temperature insensitive optical receiver

US 11342472	Huang et al.
FUNDED BY	National Security Agency (NSA)
APPLICANT(S)	HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas)
ASSIGNEE(S)	Hewlett Packard Enterprise Development LP (Houston, Texas)
INVENTOR(S)	Zhihong Huang (Palo Alto, California); Di Liang (Santa Barbara, California); Yuan Yuan (Palo Alto, California)
ABSTRACT	A device may include: a highly doped n⁺ Si region; an intrinsic silicon multiplication region disposed on at least a portion of the n⁺ Si region, the intrinsic silicon multiplication having a thickness of about 90-110 nm; a highly doped p⁻ Si charge region disposed on at least part of the intrinsic silicon multiplication region, the p⁻ Si charge region having a thickness of about 40-60 nm; and a p⁺ Ge absorption region disposed on at least a portion of the p⁻ Si charge region; wherein the p⁺ Ge absorption region is doped across its entire thickness. The thickness of the n⁺ Si region may be about 100 nm and the thickness of the p⁻ Si charge region may be about 50 nm. The p⁺ Ge absorption region may confine the electric field to the multiplication region and the charge region to achieve a temperature stability of 4.2 mV/° C.
FILED	Monday, June 15, 2020
APPL NO	16/902135
ART UNIT	2815 — Semiconductors/Memory
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/028 (20130101) H01L 31/105 (20130101) Original (OR) Class H01L 31/1804 (20130101) Transmission H04B 10/66 (20130101) Multiplex Communication H04J 14/02 (20130101)
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Department of Veterans Affairs (DVA)

11337622 — Method and apparatus for providing economical, portable deficit-adjusted adaptive assistance during movement phases of an impaired ankle

US 11337622	Macko et al.
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)	UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia)
INVENTOR(S)	Richard F. Macko (Ellicott City, Maryland); Anindo Roy (Baltimore, Maryland)
ABSTRACT	A method is described for providing deficit-adjusted adaptive assistance during movement phases of an impaired ankle. The method includes determining, on the processor, a value for a deficit parameter for each movement phase of a compound ankle function based on a difference between a parameter trace for a normal subject and the parameter trace for an impaired subject. The method further includes determining, on the processor, an adaptive magnitude for the robot-applied torque based on the value for the deficit parameter. The method further includes applying, to the robot joint, the adaptive magnitude for the robot-applied torque in only a first plane for the current movement phase, based on an adaptive timing. An apparatus is also described for providing deficit-adjusted adaptive assistance during movement phases of the impaired ankle.
FILED	Monday, June 20, 2016
APPL NO	15/738611
ART UNIT	3785 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/1122 (20130101) Original (OR) Class A61B 5/4528 (20130101) A61B 5/4595 (20130101) A61B 5/4851 (20130101) A61B 2505/09 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) A61H 2201/0157 (20130101) A61H 2201/164 (20130101) A61H 2201/165 (20130101) A61H 2201/1207 (20130101) A61H 2201/1463 (20130101) A61H 2201/1614 (20130101) A61H 2201/1623 (20130101) A61H 2201/1676 (20130101) A61H 2201/5005 (20130101) A61H 2201/5007 (20130101) A61H 2201/5012 (20130101) A61H 2201/5015 (20130101) A61H 2201/5043 (20130101) A61H 2201/5058 (20130101) A61H 2201/5061 (20130101) A61H 2201/5064 (20130101) A61H 2201/5069 (20130101) A61H 2201/5079 (20130101) A61H 2201/5092 (20130101) A61H 2201/5097 (20130101) A61H 2205/102 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/45108 (20130101)
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11339190 — Peptides for the treatment of covid-19

US 11339190	Pahan
FUNDED BY	Department of Veterans Affairs (DVA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Complementary and Integrative Health (NCCIH) National Institute on Aging (NIA) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	Rush University Medical Center (Chicago, Illinois)
ASSIGNEE(S)	Rush University Medical Center (Chicago, Illinois)
INVENTOR(S)	Kalipada Pahan (Skokie, Illinois)
ABSTRACT	Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed.
FILED	Wednesday, December 23, 2020
APPL NO	17/133035
ART UNIT	1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Office of the Director of National Intelligence (ODNI)

11342919 — Complementary asynchronous single flux quantum circuits

US 11342919	Whiteley
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	Synopsys, Inc. (Mountain View, California)
ASSIGNEE(S)	Synopsys, Inc. (Mountain View, California)
INVENTOR(S)	Stephen Robert Whiteley (Sunnyvale, California)
ABSTRACT	A single flux quantum (SFQ) cell may include SFQ circuitry to implement a logic function that generates logic values of a set of outputs based on logic values of a set of inputs. The SFQ circuitry may instantaneously update logic values of the set of outputs in response to changes in logic values of the set of inputs. The SFQ circuitry may include at least one SFQ non-destructive set-reset flip-flop.
FILED	Friday, August 21, 2020
APPL NO	16/999957
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 3/38 (20130101) H03K 19/195 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

11342921 — Single flux quantum buffer circuit

US 11342921	Whiteley
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Office of the Director of National Intelligence (ODNI) Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S)	Synopsys, Inc. (Mountain View, California)
ASSIGNEE(S)	Synopsys, Inc. (, None)
INVENTOR(S)	Stephen Robert Whiteley (Sunnyvale, California)
ABSTRACT	A circuit can include a first Josephson junction (JJ), a second JJ, and a third JJ coupled in parallel using superconducting inductors. The first JJ, the second JJ, and the third JJ can be biased using one or more JJ-based current sources.
FILED	Friday, July 10, 2020
APPL NO	16/926388
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 17/92 (20130101) H03K 19/0008 (20130101) H03K 19/1952 (20130101) Original (OR) Class H03K 2217/0036 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

United States Postal Service (USPS)

11337538 — Anti-tearing retractable arm for a collection box

US 11337538	Shenhar et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Joram Shenhar (Fairfax, Virginia); Joel Locknauth Dewnandan (Bladensburg, Maryland); William Albert Tartal (Baltimore, Maryland)
ABSTRACT	A retractable arm device, system, and method with a locking mechanism for preventing items placed in a device or receptacle from getting stuck, damaged, or torn. The retractable arm includes an inner tube, a pawl, and an outer tube surrounding the inner tube. The inner tube slides within the outer tube and the pawl preventing the retractable arm from moving into an extended position under particular conditions. The retractable arm may be placed in a receptacle for items to prevent the door from being reopened before the door is fully closed.
FILED	Tuesday, July 21, 2020
APPL NO	16/934996
ART UNIT	3677 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware
CURRENT CPC	Household or Table Equipment A47G 29/22 (20130101) A47G 29/122 (20130101) Original (OR) Class A47G 29/1207 (20130101) A47G 29/1251 (20170801) Devices for Moving Wings into Open or Closed Position; Checks for Wings; Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05F 1/1008 (20130101) E05F 5/08 (20130101) Safes or Strong-rooms for Valuables; Bank Protection Devices; Safety Transaction Partitions E05G 7/001 (20130101) Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2201/224 (20130101) E05Y 2800/41 (20130101) E05Y 2800/75 (20130101) E05Y 2800/122 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

11338329 — Systems and methods for sorting residual items

US 11338329	Bombaugh et al.
FUNDED BY	United States Postal Service (USPS)
APPLICANT(S)	United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)	United States Postal Service (Washington, District of Columbia)
INVENTOR(S)	Scott R. Bombaugh (Burke, Virginia); Thomas J. Foti (Annandale, Virginia); David E. Loyd (Stafford, Virginia); Sarvang D. Shah (Fairfax, Virginia)
ABSTRACT	Embodiments of a system and method for sorting and delivering articles in a processing facility. Delivery endpoints are divided and grouped into stop groups. A first sorter sorts items according to stop group and outputs the items to trays. The output trays from the first sorter are loaded to a second sorter. The second sorter sorts items for each stop group into trays based on carrier route segments. A manifest is created that comprises a list of the items in a tray. A mobile computing device alerts a delivery carrier when there is an item that needs to be delivered.
FILED	Friday, July 17, 2020
APPL NO	16/932492
ART UNIT	3655 — Material and Article Handling
CURRENT CPC	Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/00 (20130101) B07C 3/005 (20130101) Original (OR) Class B07C 3/14 (20130101) B07C 2301/0041 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Classified Government Agency

11342679 — Low profile monocone antenna

US 11342679	Marshall et al.
FUNDED BY	Classified Government Agency
APPLICANT(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S)	BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S)	John Marshall (Bedford, New Hampshire); William G. Collins (Hudson, New Hampshire); Peter J. Frappier (Litchfield, New Hampshire); Timothy J. McLinden (Nashua, New Hampshire); Robert W. Rogers (Rochester, New Hampshire)
ABSTRACT	A monocone antenna with an impedance matching section that may allow a reduction in physical size of the cone while maintaining similar performance as a standard monocone antenna. Alternatively, the present disclosure may provide a monocone antenna with an impedance matching section that may allow operation at a lower frequency while maintaining the same physical size as a standard monocone antenna. Further, the present disclosure may provide a monocone antenna with an impedance matching section that may allow a reduction in physical size and operation at a lower frequency relative to a standard monocone antenna.
FILED	Wednesday, September 30, 2020
APPL NO	17/038827
ART UNIT	2844 — Electrical Circuits and Systems
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/42 (20130101) H01Q 1/50 (20130101) H01Q 1/526 (20130101) H01Q 13/02 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

11339387 — Modified foot-and-mouth disease virus 3C proteases and methods for processing FMDV P1 precursor polypeptide

US 11339387	Puckette et al.
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Michael Puckette (Waterford, Connecticut); John Neilan (Wethersfield, Connecticut)
ABSTRACT	The disclosure is directed to an isolated polynucleotide encoding a modified picornavirus 3C protease, wherein the modified picornavirus 3C protease includes an altered secondary structure and one or more amino acid substitution(s) located at one or more amino acid position(s) corresponding to positions 16-25, 99-100 and 115-130 of a wild-type Fool-and-Mouth Disease Virus (FMDV) 3C protease, wherein the isolated polynucleotide encoding the modified picornavirus 3C protease, when transformed into and co-expressed in a host cell, enhances transgene expression of a P1 precursor polypeptide in comparison to an amount of P1 precursor polypeptide transgene expression exhibited in a host cell transformed and co-expressed with a control picornavirus 3C protease, wherein the one or more corresponding amino acid position(s) is/are identified by an alignment of the modified picornavirus 3C protease with the one or more of the wild type FMDV 3C protease(s). Methods for processing a picornavirus P1 precursor polypeptide into picornavirus viral proteins and/or virus-like particles using the isolated polynucleotides are also provided.
FILED	Tuesday, May 22, 2018
APPL NO	15/986214
ART UNIT	1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/135 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 2770/32034 (20130101) Enzymes C12Y 304/22028 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Non-Profit Organization (NPO)

11337647 — Quantification of in vivo metabolite

US 11337647	Reddy et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute on Drug Abuse (NIDA) Non-Profit Organization (NPO) Susan G. Komen Foundation (SGKF)
APPLICANT(S)	The Trustees of The University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)	The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S)	Ravinder Reddy (Gladwynne, Pennsylvania); Ravi Prakash Reddy Nanga (Philadelphia, Pennsylvania); Hari Hariharan (Mount Laurel, New Jersey)
ABSTRACT	A magnetic resonance pulse sequence technique may acquire a water reference spectrum and two water suppressed metabolite spectra and with frequency selective inversion pulse centered at either single frequency, at multiple frequencies, or in a single acquisition. Subtraction of the inverted from non-inverted water suppressed metabolite spectrum results in single or a combination of specific metabolite peak/peaks alone with a flat baseline for easier quantification.
FILED	Friday, April 04, 2014
APPL NO	14/782472
ART UNIT	3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4064 (20130101) A61B 5/4839 (20130101) A61B 5/4848 (20130101) Original (OR) Class A61B 5/4866 (20130101) A61B 5/14546 (20130101) A61B 2560/0475 (20130101) A61B 2576/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/483 (20130101) G01R 33/5601 (20130101) G01R 33/5605 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Small Business Administration (SBA)

11342723 — Counter pumping a large mode area fiber laser

US 11342723	Sipes, Jr.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
ASSIGNEE(S)	OPTICAL ENGINES, INC. (Colorado Springs, Colorado)
INVENTOR(S)	Donald Lee Sipes, Jr. (Colorado Springs, Colorado)
ABSTRACT	A fiber optic assembly includes: a gain fiber configured to output signal light; a first taper configured to expand the signal light output by the gain fiber; and a reversing prism configured to receive counter-pumping light and output the counter-pumping light into the first taper. The first taper is further configured to direct the counter-pumping light towards the gain fiber.
FILED	Tuesday, July 16, 2019
APPL NO	16/513191
ART UNIT	3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0621 (20130101) H01S 3/2333 (20130101) H01S 3/06745 (20130101) H01S 3/06754 (20130101) H01S 3/09415 (20130101) H01S 3/094003 (20130101) H01S 3/094053 (20130101) Original (OR) Class
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

How To Use This Page

What You'll Find On This Page

THE FEDINVENT PATENT DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Tuesday, May 24, 2022.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract as it appears on the patent.

FILED
The date of the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/details-patents-20220524.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

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